chelating agents

Summary

Summary: Organic chemicals that form two or more coordination bonds with a central metal ion. Heterocyclic rings are formed with the central metal atom as part of the ring. Some biological systems form metal chelates, e.g., the iron-binding porphyrin group of hemoglobin and the magnesium-binding chlorophyll of plants. (From Hawley's Condensed Chemical Dictionary, 12th ed) They are used chemically to remove ions from solutions, medicinally against microorganisms, to treat metal poisoning, and in chemotherapy protocols.

Top Publications

  1. ncbi Differential Ca2+-dependence of transmitter release mediated by P/Q- and N-type calcium channels at neonatal rat neuromuscular junctions
    Marcelo D Rosato-Siri
    , , Facultad de Ciencias, Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II 2 do piso, Buenos Aires (1428, Argentina
    Eur J Neurosci 15:1874-80. 2002
  2. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
  3. ncbi Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
  4. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
  5. ncbi Zinc at glutamatergic synapses
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuroscience 158:126-36. 2009
  6. ncbi Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
  7. ncbi Chelators as antidotes of metal toxicity: therapeutic and experimental aspects
    Maja Blanusa
    Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, P O Box 291, HR 10001 Zagreb, Republic of Croatia
    Curr Med Chem 12:2771-94. 2005
  8. ncbi Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride
    Valerie Autissier
    School of Natural Sciences Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    J Pharm Sci 96:2818-27. 2007
  9. ncbi Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+
    Y Li
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci 21:8015-25. 2001
  10. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001

Research Grants

  1. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
  2. Sperm DNA damage in fertilization
    MONIKA WARD; Fiscal Year: 2006
  3. Development of Chemical Tools to Probe and Inhibit Iron-Induced Oxidative Stress
    Katherine J Franz; Fiscal Year: 2010
  4. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2010
  5. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2010
  6. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2011
  7. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth Raymond; Fiscal Year: 2009
  8. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2007
  9. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2009
  10. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010

Detail Information

Publications297 found, 100 shown here

  1. ncbi Differential Ca2+-dependence of transmitter release mediated by P/Q- and N-type calcium channels at neonatal rat neuromuscular junctions
    Marcelo D Rosato-Siri
    , , Facultad de Ciencias, Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II 2 do piso, Buenos Aires (1428, Argentina
    Eur J Neurosci 15:1874-80. 2002
    ..This difference could be accounted for by a differential location of these channels at the release site. In addition, our results indicate that space-time overlapping of calcium domains was required for facilitation...
  2. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
    ..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
  3. ncbi Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
    ..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
  4. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  5. ncbi Zinc at glutamatergic synapses
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuroscience 158:126-36. 2009
    ..Finally, we present and compare two widely used zinc chelators, CaEDTA and tricine, and show why tricine should be preferred to CaEDTA when studying fast transient zinc elevations as may occur during synaptic activity...
  6. ncbi Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  7. ncbi Chelators as antidotes of metal toxicity: therapeutic and experimental aspects
    Maja Blanusa
    Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, P O Box 291, HR 10001 Zagreb, Republic of Croatia
    Curr Med Chem 12:2771-94. 2005
    ..Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects...
  8. ncbi Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride
    Valerie Autissier
    School of Natural Sciences Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    J Pharm Sci 96:2818-27. 2007
    ..These findings indicate that LC binds phosphate more effectively than SH across the pH range encountered in the gastrointestinal tract, and has a lower propensity for bound phosphate to be displaced by competing anions in the intestine...
  9. ncbi Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+
    Y Li
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci 21:8015-25. 2001
    ..These results indicate that synaptically released Zn(2+), acting as a second messenger, is necessary for the induction of LTP at mossy fiber-->CA3 synapses of hippocampus...
  10. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  11. ncbi Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 21:1331-40. 2010
    ..The IMP467 peptide could be labeled up to 115 GBq/micromol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification...
  12. ncbi Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study
    U Merle
    Department of Gastroenterology, University Hospital Heidelberg, Neuenheimer Feld 410, Heidelberg 69120, Germany
    Gut 56:115-20. 2007
    ..Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. Objective and..
  13. ncbi p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging
    Lars R Perk
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:250-9. 2010
    ..To enable widespread use of (89)Zr-immuno-PET, we now introduce the novel BFC p-isothiocyanatobenzyl-desferrioxamine B (Df-Bz-NCS) and compare its performance in (89)Zr-immuno-PET with the reference BFC TFP-N-sucDf...
  14. ncbi Chelate assisted phytoextraction of heavy metals from soil. Effect, mechanism, toxicity, and fate of chelating agents
    Michael W H Evangelou
    Institut für Biologie V, RWTH Aachen, Worringerweg 1, 52056 Aachen, Germany
    Chemosphere 68:989-1003. 2007
    ..The application of chelating agents has shown positive effects in increasing the solubility of heavy metals in soil and therefore in enhancing ..
  15. ncbi The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1
    Ying Wang
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Biol Chem 284:314-23. 2009
    ..Our findings support the hypothesis that pharmacologically targeting aging-associated proteins could help relieve age-dependent diseases...
  16. ncbi Lead-induced peripheral neuropathy following Ayurvedic medication
    Surjit Singh
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Sci 63:408-10. 2009
    ..He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal. The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning...
  17. ncbi Lanthanum carbonate vs. sevelamer hydrochloride for the reduction of serum phosphorus in hemodialysis patients: a crossover study
    S M Sprague
    NorthShore University Healthsystem, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Clin Nephrol 72:252-8. 2009
    ..The aim of this crossover study was to compare the reduction of serum phosphorus (SP) with fixed doses of the non-calcium-containing phosphate binders lanthanum carbonate (LC) and sevelamer hydrochloride (SH) in hemodialysis patients...
  18. ncbi High-yielding aqueous 18F-labeling of peptides via Al18F chelation
    Christopher A D'Souza
    Immunomedics Inc, 300 American Road, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 22:1793-803. 2011
    ..These results demonstrate the facile application of Al(18)F chelation using BFC 1 as a versatile labeling method for radiofluorinating other heat-stable peptides for positron emission imaging...
  19. ncbi A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients
    Steven C Cheng
    Division of Nephrology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8129, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 3:1131-8. 2008
    ..A prospective, randomized, double-blind, placebo-controlled crossover trial was performed for assessment of the safety and efficacy of niacinamide...
  20. ncbi Assessment of survival in a 2-year comparative study of lanthanum carbonate versus standard therapy
    R Wilson
    Spica Consultants Ltd, Marlborough, UK
    Curr Med Res Opin 25:3021-8. 2009
    ..However, few studies have comprehensively evaluated the survival benefit associated with different phosphate binders. A post-hoc survival analysis was undertaken of lanthanum carbonate (Fosrenol *) versus standard therapy...
  21. ncbi Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Treat Rev 35:32-46. 2009
    ..Therefore, the elevated copper levels and increased oxidative stress in cancer cells provide for a prospect of selective cancer treatment...
  22. ncbi Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine
    Maria J W D Vosjan
    Department of Otolaryngology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Protoc 5:739-43. 2010
    ..The entire process of pre-modification, radiolabeling and purification steps will take about 2.5 h...
  23. ncbi Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008
    ....
  24. ncbi Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS)
    H V Aposhian
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721 0106, USA
    Environ Health Perspect 106:1017-25. 1998
    ..Because South American animals studied were deficient in arsenite methyltransferase, a hypothesis is presented that arsenite and arsenite methyltransferase may have had a role in the evolution of some South American animals...
  25. ncbi Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
    Saeid Ghavami
    Clinical Biochemistry Department, Faculty of Medical Sciences, Tarbiat Modaress University, P O BOX 14115 111, Tehran, I R, Iran
    J Leukoc Biol 76:169-75. 2004
    ....
  26. ncbi A randomized, double-blind, crossover design study of sevelamer hydrochloride and sevelamer carbonate in patients on hemodialysis
    J Delmez
    Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Nephrol 68:386-91. 2007
    ..The study investigated the effects of sevelamer carbonate and sevelamer hydrochloride on serum phosphorus, lipids and bicarbonate levels in hemodialysis patients...
  27. ncbi Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon
    Christian Petzelt
    University Hospital Charite, Clinic for Anesthesiology and Intensive Care, Experimental Anesthesiology, FH 31, Spandauer Damm 130, 14050 Berlin, Germany
    Life Sci 72:1909-18. 2003
    ....
  28. ncbi Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Craig W Ritchie
    Departments of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Arch Neurol 60:1685-91. 2003
    ..CONCLUSION: Subject to the usual caveats inherent in studies with small sample size, this pilot phase 2 study supports further investigation of this novel treatment strategy using a metal-protein-attenuating compound...
  29. ncbi Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats
    Manisha Pande
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
    Toxicology 177:187-96. 2002
    ..in brain lead concentration in animals administered LA plus thiol chelators, compared to the effects of chelating agents alone. This is an interesting and notable observation, which requires further exploration...
  30. ncbi A comparative review of the efficacy and safety of established phosphate binders: calcium, sevelamer, and lanthanum carbonate
    Stuart M Sprague
    Division of Nephrology and Hypertension, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Curr Med Res Opin 23:3167-75. 2007
    ..Three major classes of phosphate binders include calcium-based binders, sevelamer HCl, and lanthanum carbonate...
  31. ncbi Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice
    Tsvia Priel
    Department of Physiology and Zlotowski Center for Neurosciences, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Pharmacol 565:232-9. 2007
    ..Taken together, our results point to the potential utility of in vivo zinc chelation as a therapeutic strategy for treatment of idiopathic type I diabetes...
  32. ncbi Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 001, India
    Biochem Pharmacol 78:1340-9. 2009
    ..We conclude that the ES-EB model seems to be an effective, faster, cost effective method for predicting efficacy of a drug...
  33. ncbi Demyelination increases radial diffusivity in corpus callosum of mouse brain
    Sheng Kwei Song
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 26:132-40. 2005
    ..Radial diffusivity offers a specific assessment of demyelination and remyelination, as distinct from acute axonal damage...
  34. ncbi Heavy metal induced oxidative stress & its possible reversal by chelation therapy
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Indian J Med Res 128:501-23. 2008
    ..Chelation therapy with chelating agents like calcium disodium ethylenediamine tetra acetic acid (CaNa(2)EDTA), British Anti Lewisite (BAL), sodium 2,..
  35. ncbi Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents
    Jose L Domingo
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, 43201 Reus, Spain
    J Alzheimers Dis 10:331-41. 2006
    ..The effects of desferrioxamine and other Al chelating agents have been reviewed...
  36. ncbi Conjugation of chelating agents to proteins and radiolabeling with trivalent metallic isotopes
    Maggie S Cooper
    Nuclear Medicine Research Laboratory, St Bartholomew's Hospital, London EC1A 7BE, UK
    Nat Protoc 1:314-7. 2006
    ..As described in the protocol that follows, the entire conjugation, purification and labeling procedure takes about 2 d...
  37. ncbi Autonomic dysfunction due to lead poisoning
    Kushal Madan
    Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar 110029, New Delhi, India
    Auton Neurosci 132:103-6. 2007
    ..At the 52nd week, most of the autonomic parameters had normalized except for the persistence of mild loss of parasympathetic reactivity...
  38. ncbi Ca(2+) -independent effects of BAPTA and EGTA on single-channel Cl(-) currents in brown adipocytes
    Victor Sabanov
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91, Stockholm, Sweden
    Biochim Biophys Acta 1768:2714-25. 2007
    ..we attempted to control Ca(2+) levels at the cytoplasmic side of the inside-out membrane patches with Ca(2+)-chelating agents. However, we found that the commonly used Ca(2+)-chelators EGTA and BAPTA by themselves influenced the Cl(-) ..
  39. ncbi The metal chelating and chaperoning effects of clioquinol: insights from yeast studies
    Chenghua Li
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing, China
    J Alzheimers Dis 21:1249-62. 2010
    ..We hope this regulation of metal homeostasis may be helpful in explaining the therapeutic effects of CQ used in disease treatment...
  40. ncbi Ca2+- and voltage-dependent inactivation of the expressed L-type Ca(v)1.2 calcium channel
    L Lacinova
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 04 Bratislava, Slovakia
    Arch Biochem Biophys 437:42-50. 2005
    ..Ca2+ ions stabilized the inactivated state of the channel in a concentration-dependent manner...
  41. ncbi Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
    ..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
  42. ncbi The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells
    Qiang Tang
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Biochem Pharmacol 74:1596-607. 2007
    ..5 channels, though its efficacy is weaker than that of BAPTA-AM. These results indicate that the membrane permeable Ca(2+) chelator BAPTA-AM (also EGTA-AM) exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels...
  43. ncbi Bioavailability and uptake of lead by coffeeweed (Sesbania exaltata Raf.)
    Gloria Miller
    Plant Physiology Microbiology Laboratory, Department of Biology, P O Box 18540, College of Science, Engineering and Technology, Jackson State University, 1000 Lynch Street, Jackson, Mississippi 39217, USA
    Int J Environ Res Public Health 5:436-40. 2008
    ..Further, these results indicate that Sesbania exaltata can be grown under elevated Pb conditions and may be suitable as a potential crop rotation species for phytoextraction...
  44. ncbi Deferoxamine as a chelator for 67Ga in the preparation of antibody conjugates
    Serengulam V Govindan
    Immunomedics, Inc, Morris Plains, NJ 07950, USA
    Nucl Med Biol 32:513-9. 2005
    ..In conclusion, DFO does not seem to be a suitable chelator for (67)Ga conjugation for our purposes...
  45. ncbi NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging
    Patrick J Riss
    Institute of Nuclear Chemistry, University of Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem Lett 18:5364-7. 2008
    ..Protein binding and exemplified conjugation are also reported...
  46. ncbi Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor
    H Vasken Aposhian
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona 85721 0106, USA
    J Toxicol Clin Toxicol 41:339-47. 2003
    ..Some medical practitioners prescribe GSH and vitamin C alone or in combination with DMPS or DMSA for patients with mercury exposure that is primarily due to the mercury vapor emitted by dental amalgams...
  47. ncbi Zinc monotherapy is not as effective as chelating agents in treatment of Wilson disease
    Karl Heinz Weiss
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Gastroenterology 140:1189-1198.e1. 2011
    ..Patients are treated with copper chelators and zinc salts, but it is not clear what approach is optimal because there have been few studies of large cohorts. We assessed long-term outcomes of different treatments...
  48. ncbi Water-elutability of nucleic acids from metal-chelate affinity adsorbents: enhancement by control of surface charge density
    Joseph Y Fu
    Department of Chemical Engineering, University of Houston, Houston, TX 77204-4004, USA
    J Mol Recognit 19:348-53. 2006
    ..Water elutability will significantly enhance the utility of IMAC in nucleic acid separations...
  49. ncbi Chelating agents in root canal treatment: mode of action and indications for their use
    M Hulsmann
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Gottingen, Germany
    Int Endod J 36:810-30. 2003
    b>Chelating agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Østby...
  50. ncbi A randomized, crossover design study of sevelamer carbonate powder and sevelamer hydrochloride tablets in chronic kidney disease patients on haemodialysis
    Stanley Fan
    Department of Nephrology, Royal London Hospital, London, UK
    Nephrol Dial Transplant 24:3794-9. 2009
    ..This study compared the safety and efficacy of sevelamer carbonate powder with sevelamer hydrochloride tablets in CKD patients on haemodialysis...
  51. ncbi [Use of the aluminum phosphate-binders in hemodialysis in the ultrapure water era]
    Maria D Arenas
    Hospital Perpetuo Socorro, Alicante
    Nefrologia 28:168-73. 2008
    ..The haemodialysis unit had a double osmosis inverse and the aluminium levels in haemodialysis liquid was less than 2 micrograms/liter...
  52. ncbi Quantifying the early stages of remyelination following cuprizone-induced demyelination
    Mark F Stidworthy
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Brain Pathol 13:329-39. 2003
    ..We also noted axonal pathology that persisted for at least 2 weeks after cuprizone withdrawal...
  53. ncbi Wilson's disease: long-term follow-up of a cohort of 24 patients treated with D-penicillamine
    Klaartje F Lowette
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur J Gastroenterol Hepatol 22:564-71. 2010
    ..Detailed data on long-term effectiveness of various drug therapies in Wilson's disease (WD) are lacking. Therefore, we retrospectively reviewed our patient cohort treated with D-penicillamine...
  54. ncbi Copper storage diseases: Menkes, Wilsons, and cancer
    Kenyon G Daniel
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Front Biosci 9:2652-62. 2004
    ..This review will examine the chemical nature and biological roles of copper, Wilsons and Menkes disease and their therapies, and the use of copper related therapies in cancer...
  55. ncbi Enhanced inhibition of Escherichia coli O157:H7 by lysozyme and chelators
    J S Boland
    Department of Food Science and Technology, University of Tennessee, 2605 River Drive, Knoxville, Tennessee 37996-4500, USA
    J Food Prot 66:1783-9. 2003
    This study examined the effects of three chelating agents (EDTA, disodium pyrophosphate [DSPP], and pentasodium tripolyphosphate [PSTPP]) on the inhibition of the growth of Escherichia coli O157:H7 by lysozyme...
  56. ncbi Environmental fate and microbial degradation of aminopolycarboxylic acids
    M Bucheli-Witschel
    Swiss Federal Institute for Environmental Science and Technology, Department of Microbiology, Uberlandstrasse 133, CH-8600, , Switzerland
    FEMS Microbiol Rev 25:69-106. 2001
    ..In contrast, the influence of metal speciation on the intracellular enzymatic breakdown of APCAs is rather well documented but no generalising pattern applicable to all enzymes was found...
  57. ncbi Ca2+-dependent interaction of BAPTA with phospholipids
    M Rousset
    CRBM, CNRS FRE2593, 1919 Route de Mende, 34293 Montpellier, France
    FEBS Lett 576:41-5. 2004
    ....
  58. ncbi Effects of chelate application time on the phytoextraction of lead-contaminated soils
    M T Begonia
    Department of Biology, Jackson State University, Jackson, MS 39217, USA
    Bull Environ Contam Toxicol 73:1033-40. 2004
  59. ncbi Metal-ion stimulation and inhibition of lysophospholipase D which generates bioactive lysophosphatidic acid in rat plasma
    A Tokumura
    Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan
    Lipids 33:1009-15. 1998
    ..These results suggest that rat plasma contains an active LPLD that differs in some properties from other members of the known phospholipase D family detected in animal tissues and body fluids...
  60. ncbi Phytoremediation of soil metals
    R L Chaney
    United States Department of Agriculture, Beltsville Agricultural Research Center West, MD 20705, USA
    Curr Opin Biotechnol 8:279-84. 1997
    ....
  61. ncbi Metal chelate affinity precipitation of RNA and purification of plasmid DNA
    Sindhu Balan
    U Houston, TX
    Biotechnol Lett 25:1111-6. 2003
    ..Bound RNA could be recovered by elution with imidazole and separated from copolymer by a second precipitation step. RNA binding showed a strong dependence on temperature and on the type of buffer used...
  62. ncbi Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin
    J Y Lee
    National Creative Research Initiative Center for the Study of CNS Zinc, University of Ulsan College of Medicine, Seoul 138 736, Korea
    J Neurosci 20:RC79. 2000
    ..However, the origin of zinc is not likely to be synaptic vesicles, because zinc accumulation robustly occurs in ZnT3-null mice lacking synaptic vesicle zinc...
  63. ncbi Endogenous mechanisms of neuroprotection: role of zinc, copper, and carnosine
    M S Horning
    Biomedical Research Facility, Department of Biological Science, Florida State University, Tallahassee 32306 4340, USA
    Brain Res 852:56-61. 2000
    ..Our results demonstrate that carnosine can rescue neurons from zinc- and copper-mediated neurotoxicity and suggest that one function of carnosine may be as an endogenous neuroprotective agent...
  64. ncbi Wilson's disease
    Aftab Ala
    UCL Institute of Hepatology, Hampstead Campus, Division of Medicine, Royal Free and University College Medical School, University College London, London, UK
    Lancet 369:397-408. 2007
    ..There are several chelating agents and zinc salts for medical therapy...
  65. ncbi Chelate-enhanced phytoextraction of lead-contaminated soils using coffeeweed (Sesbania exaltata Raf.)
    G B Begonia
    Department of Biology, Jackson State University, MS 39217, USA
    Bull Environ Contam Toxicol 69:624-31. 2002
  66. ncbi Phytoremediation of heavy metal-contaminated soils: natural hyperaccumulation versus chemically enhanced phytoextraction
    E Lombi
    Agriculture and Environment Division, IACR-Rothamsted, Harpenden, Hertfordshire
    J Environ Qual 30:1919-26. 2001
    ..High concentrations of heavy metals in soil pore water after EDTA treatment could pose an environmental risk in the form of ground water contamination...
  67. ncbi Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase
    Maria Pia Rigobello
    Dipartimento di Chimica Biologica, , Viale G. Colombo 3, 35121 Padova, Italy
    Biochem Biophys Res Commun 343:873-8. 2006
    ..These observations are discussed with reference to the physiological role and, in particular, to the regulatory functions of the thioredoxin system...
  68. ncbi Characterization and in vitro cytotoxicity testing of ethanolamine-derived cadmium chelating agents
    Mikhail Zhukalin
    Departments of Chemistry, Albertson College of Idaho, Caldwell, Idaho 83605 4432, USA
    Biometals 20:61-72. 2007
    ..Thus 1 appears more effective than 2 in the ability to mediate the cytotoxic effects of cadmium in vitro upon concomitant administration...
  69. ncbi DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Stroke 39:1774-8. 2008
    ..We present the results of a multicenter, double-blind, placebo-controlled, randomized trial to assess the safety and potential protective effects of DP-b99 in acute ischemic stroke...
  70. ncbi The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators
    Yang Zheng
    Department of Cardiovascular Diseases, Jilin University First Clinical College, Changchun, People s Republic of China
    Hemoglobin 32:135-45. 2008
    ..The essentiality, toxicity and roles of these metals in the pathogenesis of diabetes and diabetic complications are discussed...
  71. ncbi Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
    Ananda Mookerjee
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, India
    Clin Cancer Res 12:4339-49. 2006
    ..CONCLUSION: Our results show the potential usefulness of CuNG in immunotherapy of drug-resistant cancers irrespective of multidrug resistance phenotype...
  72. ncbi Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats
    Deming Gong
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Pharmacol 70:2045-51. 2006
    ..These findings are relevant to the restoration toward normal by TETA treatment of cardiac and arterial structure and function in diabetes...
  73. ncbi A copper chelating agent suppresses carbonyl stress in diabetic rat lenses
    Yoji Hamada
    Division of Metabolic Diseases, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Diabetes Complications 19:328-34. 2005
    ..The results indicate that transition metals play a significant role in the formation of MG and 3-DG via oxidative stress and SSAO activity...
  74. ncbi Chelators at the cancer coalface: desferrioxamine to Triapine and beyond
    Yu Yu
    Iron Metabolism and Chelation Program, Department of Pathology, University of Sydney, Sydney, New South Wales, Australia
    Clin Cancer Res 12:6876-83. 2006
    ..In this review, we will discuss the development of these and other chelators that show potential as anticancer agents...
  75. ncbi Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Life Sci 77:2324-37. 2005
    ..However, these chelating agents are compromised with number of limitations due to their lipophobic nature, particularly for their use in ..
  76. ncbi The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus
    Jie Zhang
    Laboratory of Visual Information Processing, Center for Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, Beijing 100101 China
    Free Radic Biol Med 37:1037-50. 2004
    ..At the same time, a reasonable deduction can also be made that the complex of OPC-Pb(2+) prevents or at least weakens the neurotoxicity of Pb(2+). Whether this complex displays toxicity over a long time span should be studied further...
  77. ncbi Role of copper in tumour angiogenesis--clinical implications
    Anna Nasulewicz
    Laboratory of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, UI. R Weigla 12, 53-114 Wroclaw, Poland
    J Trace Elem Med Biol 18:1-8. 2004
    ..The role of copper ions in tumour angiogenesis is discussed. The new antiangiogenic therapies based on a reduction of copper levels in tumour microenvironment are reviewed...
  78. ncbi The lipophilic zinc chelator DP-b99 prevents zinc induced neuronal death
    Ronit Barkalifa
    Morphology, and The Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Pharmacol 618:15-21. 2009
    ..Our results indicate that DP-b99 is effective in attenuating Zn(2+) and Ca(2+) surges and protecting neurons against a toxic Zn(2+)-rise. This may underlie the efficacy of DP-b99 in stroke treatment...
  79. ncbi The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity
    Thomas Clouaire
    Laboratoire de Biologie Vasculaire, Equipe Labellisée La Ligue 2003, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse, France
    Proc Natl Acad Sci U S A 102:6907-12. 2005
    ....
  80. ncbi Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy
    Isabelle Hininger
    Laboratoire NVMC (Nutrition, Vieillissement, Maladies Cardiovasculaires, EA 3746, J. Fourier University, Domaine de la Merci, 38700 La Tronche, France
    Free Radic Biol Med 38:1565-70. 2005
    ..However, standard high amounts of vitamin C added to EDTA chelation solutions also display short term prooxidant effects. The added benefits of lower levels of vitamin C in chelation therapy need to be documented...
  81. ncbi Clioquinol treatment in familiar early onset of Alzheimer's disease: a case report
    B Ibach
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitatsstrasse 84, Regensburg, Germany
    Pharmacopsychiatry 38:178-9. 2005
    ..In one case CSF-tau and beta-Amyloid (42/40) concentrations changed during CQ treatment...
  82. ncbi Chemical and biological considerations in the treatment of metal intoxications by chelating agents
    Ole Andersen
    Department of Life Sciences and Chemistry, Roskilde University Postboks 260, 4000 Roskilde, Denmark
    Mini Rev Med Chem 4:11-21. 2004
    ..Still, development of new safer chelators suited for long-term oral administration for chelation of metal deposits, mainly iron, is an important challenge to the future research...
  83. ncbi Gelsolin mediates calcium-dependent disassembly of Listeria actin tails
    Laura Larson
    Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 102:1921-6. 2005
    ..These experiments illustrate the unique and complementary functions of gelsolin and ADF/cofilin in the recycling of actin filaments...
  84. ncbi Reversal of arsenic-induced hepatic apoptosis with combined administration of DMSA and its analogues in guinea pigs: role of glutathione and linked enzymes
    Deepshikha Mishra
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Chem Res Toxicol 21:400-7. 2008
    ..On the basis of the above observations, we recommend that combinational therapy of DMSA and its long carbon chain analogues MiADMSA or MchDMSA would be more effective in arsenic toxicity...
  85. ncbi Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination
    Helga Jurevics
    Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-7250, USA
    J Neurochem 82:126-36. 2002
    ..The ability to correlate gene expression with known pathophysiological events should help in elucidating further function of such genes as related to demyelination/remyelination...
  86. ncbi Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease
    Lissette R Perez
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Dalton Trans 39:2177-87. 2010
    ..Metal-chelating agents provide one such function as an intervention for ameliorating metal-associated damage in degenerative ..
  87. ncbi Calcium binding to proteins studied via competition with chromophoric chelators
    Sara Linse
    Department of Physical Chemistry 2, Lund University, Lund, Sweden
    Methods Mol Biol 173:15-24. 2002
  88. ncbi CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons
    Xiaomei Qin
    Institute of Vascular Medicine, Peking University Third Hospital, Beijing, People's Republic of China
    J Neurosci Res 82:51-62. 2005
    ....
  89. ncbi Cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors
    B Pajak
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland
    J Physiol Pharmacol 56:101-18. 2005
    ..Further studies revealed that CHX treatment reduces the level of FLIP but not other members of TNF-alpha-dependent death signalosome...
  90. ncbi EDTA chelation effects on urinary losses of cadmium, calcium, chromium, cobalt, copper, lead, magnesium, and zinc
    R S Waters
    Waters Preventive Medical Center Ltd, Wisconsin Dells, WI 53965, USA
    Biol Trace Elem Res 83:207-21. 2001
    ..These effects are likely to have significant effects on nutrient concentrations and interactions and partially explain the clinical improvements seen in patients undergoing EDTA chelation therapy...
  91. ncbi Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands
    Sung Han
    System Bio Dynamics NCRC, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Biol Chem 280:38228-34. 2005
    ..Our results suggest that bradykinin-induced calcium inhibits melatonin synthesis through the mediation of adenylyl cyclase type 6 expression...
  92. ncbi Bisperoxovanadium complex promotes dopamine exocytosis in PC12 cells
    S Bieger
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Canada H3G 1Y6
    Neurochem Int 40:307-14. 2002
    ..05). These results suggest that this peroxovanadium complex enhances dopamine exocytosis, at least in part, by ERK-mediated signaling pathway and synaptophysin-associated phosphatase(s)...
  93. ncbi Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner
    Noriyuki Hatae
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606, Japan
    Biochem Biophys Res Commun 290:162-8. 2002
    ..These findings suggest that the C-terminal tail of the EP3beta receptor is not essentially involved in activation of EP2 receptor-stimulated adenylyl cyclase in a Ca(2+)/calmodulin-dependent but Gbetagamma subunit-independent manner...
  94. ncbi Spontaneous changes in mitochondrial membrane potential in cultured neurons
    J F Buckman
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
    J Neurosci 21:5054-65. 2001
    ..We hypothesize that these DeltaPsi(m) fluctuations are dependent on the proper functioning of the mitochondria and reflect mitochondria alternating between the active and inactive states of oxidative phosphorylation...
  95. ncbi The effect of calcium chelating or binding agents on Candida albicans
    Mustafa Ates
    Department of Biology, Division of Basic and Industrial Microbiology, School of Science, Ege University, Izmir, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:626-30. 2005
    ..CONCLUSION: EDTA and TiF4 may be recommended as an alternative irrigating solution particularly in persistent root canal infections and in root canals of patients having a high incidence of oral candidosis...
  96. ncbi Ion regulation of homotypic vacuole fusion in Saccharomyces cerevisiae
    Vincent J Starai
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755-3844, USA
    J Biol Chem 280:16754-62. 2005
    ....
  97. ncbi Copper and trace element fractionation in electrokinetically treated methanogenic anaerobic granular sludge
    Jurate Virkutyte
    Subdepartment of Environmental Technology, University of Wageningen, Biotechnion-Bomenweg 2, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Environ Pollut 138:517-28. 2005
    ..The presence of sulfide precipitates likely influences the copper mobilisation from these less mobile fractions, and thus makes EDTA addition ineffective to solubilise copper from the granules...
  98. ncbi Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents
    L Lemonnier
    Laboratoire de Physiologie Cellulaire, INSERM EPI 9938, , USTL, 59655 Villeneuve d'Ascq, France
    FEBS Lett 521:152-6. 2002
    Ca(2+) chelating agents are widely used in biological research for Ca(2+) buffering...
  99. ncbi Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralization
    Wei Wang
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA
    J Cell Biol 157:1061-9. 2002
    ....
  100. ncbi Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases
    Michelle K Y Siu
    Center for Biomedical Research, Population Council, New York, New York 10021, USA
    J Biol Chem 280:25029-47. 2005
    ..In summary, these results illustrate that Sertoli-germ cell anchoring junction dynamics in the testis are regulated, at least in part, via the beta1-integrin/PI3K/PKB/ERK signaling pathway...
  101. ncbi Metal ion modulation of cystinyl aminopeptidase
    Hilde Laeremans
    Department of Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium
    Biochem J 390:351-7. 2005
    ..These findings support the concept that high-affinity [125I]angiotensin IV binding, previously referred to as 'AT4 receptor binding', only occurs for the cystinyl aminopeptidase apoenzyme...

Research Grants83

  1. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
    ..Approved chelating agents for severe plumbism are CaNa2EDTA (edetate disodium calcium) and succimer...
  2. Sperm DNA damage in fertilization
    MONIKA WARD; Fiscal Year: 2006
    ....
  3. Development of Chemical Tools to Probe and Inhibit Iron-Induced Oxidative Stress
    Katherine J Franz; Fiscal Year: 2010
    ..Our long-term goals are to develop medicinal iron chelating agents that selectively inhibit this deleterious iron-promoted damage at the site of oxidative stress while avoiding ..
  4. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2010
    ..The proposed research is expected to validate siderophore biosynthesis as new antibacterial target, which may lead to the development of a new class of antitubercular agents. ..
  5. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2010
    ..in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  6. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2011
    ..in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  7. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth Raymond; Fiscal Year: 2009
    ..in microbial growth; bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  8. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2007
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  9. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2009
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  10. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  11. DERMATOREMEDIATION OF IRON OVERLOAD
    LEONARD MILSTONE; Fiscal Year: 2007
    ..Since iron is increasingly suspected of having a role in inflammatory and neoplastic diseases of skin, this new information should assist in devising preventative and treatment measures for those types of diseases. ..
  12. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..The potential of identifying novel therapeutic targets to prevent or treat infections is also proposed. ..
  13. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2006
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT-based chelators may proceed rapidly. ..
  14. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2010
    ..An associated objective is to prepare zinc-selective, rapid chelating agents to be used in conjunction with investigations of the biological functions of mobile Zn2+...
  15. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    ..New improved chelating agents for these metal ions have been designed...
  16. MECHANISMS FOR OXIDATIVE STRESS INDUCED APOPTOSIS
    KATHRYN HELD; Fiscal Year: 1999
    ..g., to enhance cell killing in tumor cells or prevent cell killing in AIDS, autoimmune diseases, neurodegenerative diseases, etc., where oxidative stress may play a role. ..
  17. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1993
    ..In this proposal it is planned to design, synthesize and study new, improved chelating agents for the complexation of these metal ions...
  18. NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALS
    Donald Buchsbaum; Fiscal Year: 2001
    ..This project focuses on the development of bifunctional chelating agents (BCAs), derived from the hydroxamic acid class of organic compounds, for radiometal labeling of MAbs with ..
  19. Lipoate Derivatives Targeting Alzheimer's Amyloid
    Xudong Huang; Fiscal Year: 2007
    ..The overall rationale for the proposal is: our understanding about the molecular mechanism(s) and therapeutic values of amyloid-targeted antioxidants/chelators as potential AD-modifying agents need to be further clarified and validated. ..
  20. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2004
    ..low molecular weight ligands tends to be very slow, which severely restricts the ability of therapeutic iron chelating agents to target this readily accessible iron pool...
  21. FACTORS REGULATING THE CELLULAR UPTAKE OF IRON
    Jerry Kaplan; Fiscal Year: 1993
    ..These studies will yield information on the mechanisms of tissue iron overload and the role of iron in normal and pathological processes...
  22. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2009
    ..We aim to develop strong-binding radiometal carriers to ensure safe delivery of copper, gallium, and indium radioisotopes for both diagnosis and treatment of cancer. ..
  23. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward H Wong; Fiscal Year: 2010
    ..We aim to develop strong-binding radiometal carriers to ensure safe delivery of copper, gallium, and indium radioisotopes for both diagnosis and treatment of cancer. ..
  24. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2007
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..