chelating agents

Summary

Summary: Organic chemicals that form two or more coordination bonds with a central metal ion. Heterocyclic rings are formed with the central metal atom as part of the ring. Some biological systems form metal chelates, e.g., the iron-binding porphyrin group of hemoglobin and the magnesium-binding chlorophyll of plants. (From Hawley's Condensed Chemical Dictionary, 12th ed) They are used chemically to remove ions from solutions, medicinally against microorganisms, to treat metal poisoning, and in chemotherapy protocols.

Top Publications

  1. pmc Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 7:934-42. 2012
  2. ncbi Selective divalent copper chelation for the treatment of diabetes mellitus
    G J S Cooper
    Room 1 004, AV Hill Building, School of Biomedicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Curr Med Chem 19:2828-60. 2012
  3. ncbi Heavy metal induced oxidative stress & its possible reversal by chelation therapy
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Indian J Med Res 128:501-23. 2008
  4. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
  5. ncbi Wilson's disease
    Aftab Ala
    UCL Institute of Hepatology, Hampstead Campus, Division of Medicine, Royal Free and University College Medical School, University College London, London, UK
    Lancet 369:397-408. 2007
  6. ncbi Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments
    J Lu
    School of Biological Sciences, Faculty of Science, University of Auckland, Private Bag, 92019 Auckland, New Zealand
    Diabetologia 53:1217-26. 2010
  7. ncbi Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia
    A E M Stinghen
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
    Blood Purif 29:352-6. 2010
  8. ncbi Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells
    Mohammad Hashemi
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
    Eur J Pharmacol 557:9-19. 2007
  9. pmc Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation
    Hsin Hung Chou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000652. 2009
  10. ncbi Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Treat Rev 35:32-46. 2009

Detail Information

Publications384 found, 100 shown here

  1. pmc Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 7:934-42. 2012
    ....
  2. ncbi Selective divalent copper chelation for the treatment of diabetes mellitus
    G J S Cooper
    Room 1 004, AV Hill Building, School of Biomedicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Curr Med Chem 19:2828-60. 2012
    ..Based on evidence from the studies reviewed herein, trientine is now proceeding into the later stages of pharmaceutical development for the treatment of heart failure and other diabetic complications...
  3. ncbi Heavy metal induced oxidative stress & its possible reversal by chelation therapy
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Indian J Med Res 128:501-23. 2008
    ..Chelation therapy with chelating agents like calcium disodium ethylenediamine tetra acetic acid (CaNa(2)EDTA), British Anti Lewisite (BAL), sodium 2,..
  4. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
    ..We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients...
  5. ncbi Wilson's disease
    Aftab Ala
    UCL Institute of Hepatology, Hampstead Campus, Division of Medicine, Royal Free and University College Medical School, University College London, London, UK
    Lancet 369:397-408. 2007
    ..There are several chelating agents and zinc salts for medical therapy...
  6. ncbi Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments
    J Lu
    School of Biological Sciences, Faculty of Science, University of Auckland, Private Bag, 92019 Auckland, New Zealand
    Diabetologia 53:1217-26. 2010
    ....
  7. ncbi Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia
    A E M Stinghen
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
    Blood Purif 29:352-6. 2010
    ..In the present study, we investigated the impact of sevelamer hydrochloride treatment in reducing endotoxemia and inflammation in a group of hemodialysis (HD) patients...
  8. ncbi Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells
    Mohammad Hashemi
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
    Eur J Pharmacol 557:9-19. 2007
    ..Interestingly, addition of Ca(2+), or Mg(2+) had no effect. The antioxidant N-Acetyl-L-Cysteine inhibited the cytotoxic effect of DTPA and TPEN, indicating that oxidative stress is the likely mediator of Zn-deficiency-related cell death...
  9. pmc Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation
    Hsin Hung Chou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000652. 2009
    ....
  10. ncbi Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Treat Rev 35:32-46. 2009
    ..Therefore, the elevated copper levels and increased oxidative stress in cancer cells provide for a prospect of selective cancer treatment...
  11. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
    ..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
  12. ncbi A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study
    G J S Cooper
    Level 4, School of Biological Sciences, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
    Diabetologia 52:715-22. 2009
    ..Here, we tested the hypothesis that Cu(II)-selective chelation might improve left ventricular hypertrophy (LVH) in type 2 diabetic patients...
  13. ncbi Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease
    Garth J S Cooper
    Centre for Advanced Discovery and Experimental Therapeutics, NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, UK
    Drugs 71:1281-320. 2011
    ....
  14. pmc Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
    ..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
  15. pmc Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
    Rodrigo B Oliveira
    Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 5:286-91. 2010
    ..This short-term 6-wk dose titration study evaluated the effect of two phosphate binders on PTH and FGF23 levels in patients with CKD stages 3 to 4...
  16. ncbi Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults
    Hea Young Cho
    565 Hochstetter Hall, Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Clin Pharmacol 49:916-28. 2009
    ..2% for slope (SL) and 82.5% for intercept (ER0). TETA has consistent single/multiple-dose pharmacokinetics and dose-proportional and serum concentration-proportional effects on enhancing copper excretion...
  17. ncbi Sevelamer hydrochloride use and circulating endotoxin in hemodialysis patients: a pilot cross-sectional study
    Phyllis P Sun
    Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Ren Nutr 19:432-8. 2009
    ..This study explores the hypothesis that sevelamer hydrochloride binds bacterial endotoxin in the intestinal tract, leading to lower circulating endotoxin levels, and offering a novel anti-inflammatory mechanism...
  18. ncbi Chelating agents for neurodegenerative diseases
    R J Ward
    Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Curr Med Chem 19:2760-72. 2012
    ..Copper and zinc homeostasis in brain and age associated changes are then outlined, along with a discussion of the possible involvement of Zn, Cu and Fe in Alzheimer's disease. We conclude with a brief summary of chelation therapy in AD...
  19. ncbi Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients
    Takatoshi Kakuta
    Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Am J Kidney Dis 57:422-31. 2011
    ..Effects of phosphate binders on circulating advanced glycation end products (AGEs) are unknown...
  20. pmc Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications
    Ryoji Nagai
    Department of Food and Nutrition, Japan Women s University, Tokyo, Japan
    Diabetes 61:549-59. 2012
    ..We conclude that chronic, low-dose chelation therapy deserves serious consideration as a clinical tool for prevention and treatment of diabetes complications...
  21. ncbi Regulation and functional effects of ZNT8 in human pancreatic islets
    Bruno Lefebvre
    Univ Lille Nord de France, F 59000 Lille, France
    J Endocrinol 214:225-32. 2012
    ..Prospects for increasing ZNT8 expression and/or activity may prove beneficial in type 2 diabetes in humans...
  22. ncbi Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
    N Lynn Henry
    Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Oncology 71:168-75. 2006
    ..In tumor models, the copper-chelating agent tetrathiomolybdate (TM) has been shown to be antiangiogenic. We evaluated the antitumor activity of TM in patients with hormone-refractory prostate cancer (HRPC)...
  23. pmc Design of the Trial to Assess Chelation Therapy (TACT)
    Gervasio A Lamas
    Mount Sinai Medical Center, Miami Beach, FL, USA
    Am Heart J 163:7-12. 2012
    ..The trial is designed to have >85% power to detect a 25% relative reduction in the primary end point for each treatment factor. Enrollment began in September 2003 and was completed in October 2010...
  24. pmc Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment
    Jun Lu
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Cardiovasc Diabetol 12:28. 2013
    ..However, direct in vivo evidence that trientine can improve cardiac function in heart failure has hitherto been lacking...
  25. pmc Effects of sevelamer and calcium-based phosphate binders on lipid and inflammatory markers in hemodialysis patients
    Ronney Shantouf
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, Calif 90502, USA
    Am J Nephrol 28:275-9. 2008
    ..A combination of lipid-lowering and anti-inflammatory effects along with avoidance of hypercalcemia should be taken into account when choosing phosphorus binders for maintenance hemodialysis (MHD) patients...
  26. ncbi The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice
    M B H Youdim
    Eve Topf and US National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research, Technion Rappaport Family Faculty of Medicine, Haifa, Israel
    J Neural Transm 114:205-9. 2007
    ..The results indicate that for prevention of MPTP-induced dopamine depletion and dopamine neurodegeneration, iron rather than copper chelation may be more effective and specific...
  27. pmc Cellular responses to the metal-binding properties of metformin
    Lisa Logie
    Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 61:1423-33. 2012
    ..Together, these results suggest that cellular effects of biguanides depend on their metal-binding properties. This link may illuminate a better understanding of the molecular mechanisms enabling antihyperglycemic drug action...
  28. ncbi Metal ionophores - an emerging class of anticancer drugs
    Wei Qun Ding
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    IUBMB Life 61:1013-8. 2009
    ..Because some of these compounds have been safely administered to animals and humans, they have the potential to become clinically useful anticancer agents...
  29. pmc Antioxidant and free radical scavenging activity of Spondias pinnata
    Bibhabasu Hazra
    Division of Molecular Medicine, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata 700054, India
    BMC Complement Altern Med 8:63. 2008
    ..Current research is directed towards finding naturally-occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of Spondias pinnata stem bark extract...
  30. pmc Mechanistic basis for overcoming platinum resistance using copper chelating agents
    Zheng D Liang
    Department of Molecular Pathology, Unit 951, Room 2SCR4 3025, The University of Texas MD Anderson Cancer Center, 7435 Fannin Blvd, Houston, TX 77054, USA
    Mol Cancer Ther 11:2483-94. 2012
    ..This study reveals the mechanistic basis for using copper chelation to overcome cDDP resistance in clinical investigations...
  31. ncbi Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage
    Haseeb Zubair
    Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, India
    Eur J Pharm Sci 47:280-6. 2012
    ..Such cellular DNA breakage is inhibited by copper specific chelator but nor by iron or zinc chelating agents. Similar results are obtained with isolated nuclei indicating that chromatin bound copper is mobilized in ..
  32. ncbi Chelating agents in root canal treatment: mode of action and indications for their use
    M Hulsmann
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Gottingen, Germany
    Int Endod J 36:810-30. 2003
    b>Chelating agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Østby...
  33. pmc Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
    Shuping Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 29:15277-85. 2009
    ..Our study suggests that the dynamic nature of the hair cell's transduction apparatus is retained despite the fact that regeneration of the hair bundle is lost in mammalian cochlear hair cells...
  34. ncbi Chelators as antidotes of metal toxicity: therapeutic and experimental aspects
    Maja Blanusa
    Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, P O Box 291, HR 10001 Zagreb, Republic of Croatia
    Curr Med Chem 12:2771-94. 2005
    ..Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects...
  35. ncbi Novel inhibitors of advanced glycation endproducts
    Samuel Rahbar
    Department of Diabetes, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Arch Biochem Biophys 419:63-79. 2003
    ....
  36. ncbi Analysis of renal impairment in children with Wilson's disease
    Xiao Hui Zhuang
    Department of Pediatrics, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    World J Pediatr 4:102-5. 2008
    ..This study was undertaken to find the clinical features of renal impairment in children with Wilson's disease or hepatolenticular degeneration (HLD)...
  37. pmc Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    Tamara Isakova
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:584-91. 2011
    ..Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD...
  38. ncbi Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats
    Deming Gong
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Pharmacol 70:2045-51. 2006
    ..These findings are relevant to the restoration toward normal by TETA treatment of cardiac and arterial structure and function in diabetes...
  39. ncbi Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats
    Manisha Pande
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
    Toxicology 177:187-96. 2002
    ..in brain lead concentration in animals administered LA plus thiol chelators, compared to the effects of chelating agents alone. This is an interesting and notable observation, which requires further exploration...
  40. ncbi Effects of chelating agents and sodium hypochlorite on mineral content of root dentin
    H Dogan
    Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Endod 27:578-80. 2001
    ..05). It was concluded that using NaOCl irrigation as final flush altered the effectiveness of chelating agents on root dentin.
  41. pmc Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis
    Yan Shou
    Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907 2091, USA
    Biochem J 379:805-13. 2004
    ..These observations show that by inducing a rapid increase in cytosolic free Ca2+, cyanide can partially initiate the apoptotic cascade through a calcineurin-mediated translocation of Bad to mitochondria...
  42. pmc An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter
    C Thelwell
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle, NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 95:10728-33. 1998
    ..Metal coordination to His-imidazole and Cys-thiolate ligands at these residues of ZiaR is thus implicated in Zn2+-perception by Synechocystis PCC 6803...
  43. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  44. ncbi Zinc at glutamatergic synapses
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuroscience 158:126-36. 2009
    ..Finally, we present and compare two widely used zinc chelators, CaEDTA and tricine, and show why tricine should be preferred to CaEDTA when studying fast transient zinc elevations as may occur during synaptic activity...
  45. pmc Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  46. ncbi Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311
    Timothy B Chaston
    The Iron Metabolism and Chelation Group, The Heart Research Institute, Camperdown, Sydney, New South Wales, 2050 Australia
    Clin Cancer Res 9:402-14. 2003
    ..This compound is a potential Fe chelator, but despite this, no investigations have examined its effect on cellular Fe metabolism. This is essential for understanding its mechanism of action and clinical effects...
  47. ncbi Anticancer activity of the antibiotic clioquinol
    Wei Qun Ding
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cancer Res 65:3389-95. 2005
    ..Our results show that clioquinol has anticancer effects both in vitro and in vivo. Transition metal ionophores may be a subclass of metal chelators with anticancer activity deserving of further development...
  48. ncbi A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes
    D Gong
    School of Biological Sciences, Faculty of Science, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Diabetologia 51:1741-51. 2008
    ..Here, we report the effects of TETA treatment on Cu and other essential elements, as well as on indices of renal injury and known pathogenic molecular processes, in kidneys from a rat model of diabetes...
  49. ncbi Regeneration of the heart in diabetes by selective copper chelation
    Garth J S Cooper
    Level 4, Thomas Building, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Diabetes 53:2501-8. 2004
    ..These data implicate accumulation of elevated loosely bound Cu in the mechanism of cardiac damage in diabetes and support the use of selective Cu chelation in the treatment of this condition...
  50. ncbi Role of copper in tumour angiogenesis--clinical implications
    Anna Nasulewicz
    Laboratory of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, UI R Weigla 12, 53 114 Wroclaw, Poland
    J Trace Elem Med Biol 18:1-8. 2004
    ..The role of copper ions in tumour angiogenesis is discussed. The new antiangiogenic therapies based on a reduction of copper levels in tumour microenvironment are reviewed...
  51. ncbi Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
    ..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
  52. ncbi DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Stroke 39:1774-8. 2008
    ..We present the results of a multicenter, double-blind, placebo-controlled, randomized trial to assess the safety and potential protective effects of DP-b99 in acute ischemic stroke...
  53. pmc Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+
    David A Andersson
    Wolfson Centre for Age Related Diseases, King s College London, London, United Kingdom
    Proc Natl Acad Sci U S A 106:8374-9. 2009
    ..We also demonstrate that CQ-evoked mechanical hyperalgesia and cold allodynia require TRPA1 in vivo...
  54. ncbi Attenuation of aortic calcification with lanthanum carbonate versus calcium-based phosphate binders in haemodialysis: A pilot randomized controlled trial
    Nigel D Toussaint
    Departments of Nephrology Radiology, Monash Medical Centre Department of Medicine, Monash University, Clayton, Victoria, Australia
    Nephrology (Carlton) 16:290-8. 2011
    ..Few controlled studies have addressed interventions to reduce VC but non-calcium-based phosphate binders may be beneficial. No published randomized study to date has assessed the effect of lanthanum carbonate (LC) on VC progression...
  55. ncbi Phytoremediation of soil metals
    R L Chaney
    United States Department of Agriculture, Beltsville Agricultural Research Center West, MD 20705, USA
    Curr Opin Biotechnol 8:279-84. 1997
    ....
  56. ncbi T-jump study of calcium binding kinetics of calcium chelators
    M Naraghi
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Cell Calcium 22:255-68. 1997
    ..EGTA and H-EDTA have small binding rate constants for calcium in the range of 3 x 10(6) M-1s-1 since, at pH 7.20, protons need to be dissociated from the chelators before they can bind calcium ions...
  57. pmc Herpes simplex virus triggers activation of calcium-signaling pathways
    Natalia Cheshenko
    Deparment of Pediatrics and Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 163:283-93. 2003
    ..Defining the pathway of viral invasion may lead to new targets for anti-viral therapy...
  58. ncbi Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride
    Valerie Autissier
    School of Natural Sciences Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    J Pharm Sci 96:2818-27. 2007
    ..These findings indicate that LC binds phosphate more effectively than SH across the pH range encountered in the gastrointestinal tract, and has a lower propensity for bound phosphate to be displaced by competing anions in the intestine...
  59. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  60. ncbi Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+
    Y Li
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci 21:8015-25. 2001
    ..These results indicate that synaptically released Zn(2+), acting as a second messenger, is necessary for the induction of LTP at mossy fiber-->CA3 synapses of hippocampus...
  61. ncbi Antimicrobial activity of maleic acid and combinations of cetrimide with chelating agents against Enterococcus faecalis biofilm
    Carmen María Ferrer-Luque
    Department of Preventive and Operative Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 36:1673-5. 2010
    b>Chelating agents, such as EDTA or citric acid, can be incorporated into irrigants in order to provide different properties in a single compound...
  62. ncbi Sevelamer decreases serum uric acid concentration through adsorption of uric acid in maintenance hemodialysis patients
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 48:415-20. 2009
    ..In this study we verify the urate-lowering effect of sevelamer in Japan in which the hemodialysis environment is different from that of western countries, and we also clarify the urate-lowering mechanism of sevelamer...
  63. pmc MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia 31207, USA
    Toxicol Sci 105:211-20. 2008
    ..Overall, these data support our hypothesis that Mrp2 is involved in the DMPS and DMSA-mediated extraction of the body burden of Hg2+...
  64. ncbi Chelatable zinc modulates excitability and seizure duration in the amygdala rapid kindling model
    Maira Licia Foresti
    Neurology, Psychiatry and Medical Psychology Department, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Epilepsy Res 79:166-72. 2008
    ..These results indicate that the zinc ion may have a facilitatory role during kindling progression...
  65. pmc Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients
    Anibal Ferreira
    Nephrology Department, Hospital Curry Cabral, Lisboa, Portugal
    J Am Soc Nephrol 19:405-12. 2008
    ..Further studies are required to assess whether these changes affect clinical outcomes, such as rates of fracture...
  66. ncbi Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of 99mTc-labeled anti-HER2 Affibody molecules
    Thuy A Tran
    Unit of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Bioconjug Chem 19:2568-76. 2008
    ..Multiple lysine residues in the chelator are, however, undesirable due to elevated uptake both in the liver and kidneys...
  67. ncbi Comparison of sevelamer hydrochloride and sevelamer carbonate: risk of metabolic acidosis and clinical implications
    Ashwini B Pai
    Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    Pharmacotherapy 29:554-61. 2009
    ..However, as sevelamer carbonate does not decrease serum bicarbonate levels, it may be more appropriate for patients at risk for metabolic acidosis who require phosphate binders that do not contain calcium or aluminum...
  68. ncbi Serological cardiovascular and mortality risk predictors in dialysis patients receiving sevelamer: a prospective study
    Vincent Matthias Brandenburg
    Department of Nephrology, University Hospital of the RWTH Aachen, Pauwelsstase 30, Aachen, Germany
    Nephrol Dial Transplant 25:2672-9. 2010
    ..We assessed how sevelamer hydrochloride influences the evolution of serum fetuin-A and other serological factors predicting cardiovascular outcome and survival in haemodialysis patients...
  69. ncbi Sensitivity enhancement of multidimensional NMR experiments by paramagnetic relaxation effects
    Sheng Cai
    Division of Immunology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    J Am Chem Soc 128:13474-8. 2006
    ..The Ni(DO2A) also significantly decreases the T(1) relaxation time of water, thus providing additional sensitivity gain by eliminating the saturation of labile amide resonances...
  70. ncbi [Phosphorus binders: preferences of patients on haemodialysis and its impact on treatment compliance and phosphorus control]
    M D Arenas
    Servicio de Nefrologia, Hospital Perpetuo Socorro
    Nefrologia 30:522-30. 2010
    ..Non-adherence to phosphate binding (PB) medication may play a role in the difficulty in achieving the targets for phosphorus. We have a wide armamentarium of PB but preferences of patients are poorly understood...
  71. ncbi Metal chelation therapy in rheumathoid arthritis: a case report. Successful management of rheumathoid arthritis by metal chelation therapy
    Fabrizia Bamonti
    Dipartimento di Scienze Mediche, Universita di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Via F Sforza 35, Milan, Italy
    Biometals 24:1093-8. 2011
    ..Oxidative status profile was carried out at the beginning and after 6 months' EDTA chelation. At the end of the treatment, the patient did not show any signs of metal intoxication, RA symptoms and oxidative status improved...
  72. pmc A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer
    Elaina M Gartner
    Wayne State University, 4100 John R, 4HWCRC, Detroit, MI 48108, USA
    Invest New Drugs 27:159-65. 2009
    ..TM can be safely added to IFL without compromising dose intensity or diminishing the expected RR. Changes in serum VEGF, IL-8, and IL-6 after treatment may directly reflect changes in CRC tissue angiogenesis...
  73. ncbi Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts
    Jennie Malmberg
    Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
    Eur J Nucl Med Mol Imaging 39:481-92. 2012
    ..The goal of this study was to develop an optimal Affibody-based tracer for visualization of HER2 expression in prostate cancer...
  74. ncbi Influence of DOTA chelator position on biodistribution and targeting properties of (111)In-labeled synthetic anti-HER2 affibody molecules
    Anna Perols
    Division of Molecular Biotechnology, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden
    Bioconjug Chem 23:1661-70. 2012
    ..In conclusion, the positioning of the DOTA chelator influences the cellular processing and the biodistribution pattern of radiolabeled affibody molecules, creating preconditions for imaging optimization...
  75. pmc Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift
    H Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics and Palliative Care, Mount Sinai School of Medicine, 1 Gustave Levy Place, NY 10029, USA
    J Gerontol A Biol Sci Med Sci 67:1410-6. 2012
    ..If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD...
  76. ncbi Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial
    Jun Lu
    School of Biological Sciences, Faculty of Science, University of Auckland, Auckland 1142, New Zealand
    J Clin Pharmacol 50:647-58. 2010
    ..Based on these data, NAT2 phenotype does not affect TETA's pharmacokinetic, pharmacodynamic, or safety profiles. TETA may be acetylated via an alternative mechanism, such as that catalyzed by spermidine/spermine N(1)-acetyltranferase...
  77. ncbi Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid
    G J Lees
    Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Auckland, New Zealand
    Brain Res 799:108-17. 1998
    The ability of metal chelating agents to affect seizure-induced neuronal death caused by intra-amygdaloid injections of kainic acid was investigated...
  78. ncbi Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Arch Toxicol 76:269-76. 2002
    ....
  79. ncbi [Prescription of phosphorus binders and calcitriol for chronic hemodialysis patients]
    Maria Tereza Silveira Martins
    Clínica NEPHRON, Universidade Federal da Bahia, Salvador, BA, Brasil
    Rev Assoc Med Bras 55:70-4. 2009
    ....
  80. ncbi Benefits and harms of phosphate binders in CKD: a systematic review of randomized controlled trials
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44122, USA
    Am J Kidney Dis 54:619-37. 2009
    ..Phosphate binders are widely used to control serum phosphorus levels in patients with chronic kidney disease (CKD). We analyzed the effects of phosphate binders on biochemical and patient-level end points in patients with CKD...
  81. pmc Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 21:1331-40. 2010
    ..The IMP467 peptide could be labeled up to 115 GBq/micromol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification...
  82. ncbi Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes
    M Donadelli
    Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Verona, Italy
    J Cell Biochem 104:202-12. 2008
    ..In this study, we suggest that zinc depletion may be an efficient strategy in the treatment of pancreatic cancer because of its reduced antiproliferative effect on normal cells...
  83. ncbi Wilson disease in children: analysis of 57 cases
    Nina Manolaki
    First Department of Pediatrics, Athens University, Aghia Sophia Children s Hospital, Athens, Greece
    J Pediatr Gastroenterol Nutr 48:72-7. 2009
    ..Affected children may be entirely asymptomatic and the diagnosis problematic. Herein we present the clinical and laboratory characteristics of 57 children with WD and point out the diagnostic difficulties in a pediatric population...
  84. pmc Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 324:383-90. 2008
    ..Collectively, these data support a role for Mrp2 in the DMPS- and DMSA-mediated elimination of Hg(2+) from the kidney...
  85. ncbi The pivotal role of intracellular calcium in oxaliplatin-induced inhibition of neurite outgrowth but not cell death in differentiated PC12 cells
    Miki Takeshita
    Department of Pharmacy Practice and Science, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Chem Res Toxicol 24:1845-52. 2011
    ..Therefore, it may be assumed that Ca/Mg is useful for protecting against oxaliplatin-induced neurotoxicity without reducing the antitumor activity of oxaliplatin...
  86. ncbi In vitro binding of heavy metals by an edible biopolymer poly(gamma-glutamic acid)
    F Y Siao
    Department of Emergency Medicine, Changhua Christian Hospital, Taiwan
    J Agric Food Chem 57:777-84. 2009
    ..Incorporation of Cu, Zn, Fe, Mg, Ca, and K showed only a minor influence on lead binding but significantly reduced the binding of cadmium...
  87. pmc Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm
    Ehud Banin
    Box 357242, Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Appl Environ Microbiol 72:2064-9. 2006
    ..aeruginosa biofilms against EDTA treatment. Our results are consistent with a mechanism whereby EDTA causes detachment and killing of biofilm cells...
  88. ncbi Influence of root-surface conditioning with acid and chelating agents on clot stabilization
    Fabio Renato Manzolli Leite
    Department of Semilogy and Clinics, School of Dentistry, Federal University of Pelotas UFPel Pelotas, Rio Grande do Sul, Brazil
    Quintessence Int 41:341-9. 2010
    ..To compare the adhesion and maturation of blood components on chemically conditioned root surfaces...
  89. ncbi AMPK-independent induction of autophagy by cytosolic Ca2+ increase
    Antje Grotemeier
    Department of Internal Medicine I, University Clinic of Tubingen, Germany
    Cell Signal 22:914-25. 2010
    ..We suggest that apart from reported AMPK-dependent regulation of autophagic degradation, an AMPK-independent pathway triggers Ca(2+)-mediated autophagy, involving the PI(3)P-effector protein WIPI-1 and LC3...
  90. ncbi Chelate assisted phytoextraction of heavy metals from soil. Effect, mechanism, toxicity, and fate of chelating agents
    Michael W H Evangelou
    Institut für Biologie V, RWTH Aachen, Worringerweg 1, 52056 Aachen, Germany
    Chemosphere 68:989-1003. 2007
    ..The application of chelating agents has shown positive effects in increasing the solubility of heavy metals in soil and therefore in enhancing ..
  91. ncbi Lanthanum carbonate vs. sevelamer hydrochloride for the reduction of serum phosphorus in hemodialysis patients: a crossover study
    S M Sprague
    NorthShore University Healthsystem, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Clin Nephrol 72:252-8. 2009
    ..The aim of this crossover study was to compare the reduction of serum phosphorus (SP) with fixed doses of the non-calcium-containing phosphate binders lanthanum carbonate (LC) and sevelamer hydrochloride (SH) in hemodialysis patients...
  92. pmc High-yielding aqueous 18F-labeling of peptides via Al18F chelation
    Christopher A D'Souza
    Immunomedics Inc, 300 American Road, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 22:1793-803. 2011
    ..These results demonstrate the facile application of Al(18)F chelation using BFC 1 as a versatile labeling method for radiofluorinating other heat-stable peptides for positron emission imaging...
  93. pmc p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging
    Lars R Perk
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:250-9. 2010
    ..To enable widespread use of (89)Zr-immuno-PET, we now introduce the novel BFC p-isothiocyanatobenzyl-desferrioxamine B (Df-Bz-NCS) and compare its performance in (89)Zr-immuno-PET with the reference BFC TFP-N-sucDf...
  94. ncbi Lead-induced peripheral neuropathy following Ayurvedic medication
    Surjit Singh
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Sci 63:408-10. 2009
    ..He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal. The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning...
  95. ncbi Assessment of survival in a 2-year comparative study of lanthanum carbonate versus standard therapy
    R Wilson
    Spica Consultants Ltd, Marlborough, UK
    Curr Med Res Opin 25:3021-8. 2009
    ..However, few studies have comprehensively evaluated the survival benefit associated with different phosphate binders. A post-hoc survival analysis was undertaken of lanthanum carbonate (Fosrenol *) versus standard therapy...
  96. ncbi Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine
    Maria J W D Vosjan
    Department of Otolaryngology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Protoc 5:739-43. 2010
    ..The entire process of pre-modification, radiolabeling and purification steps will take about 2.5 h...
  97. pmc A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients
    Steven C Cheng
    Division of Nephrology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8129, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 3:1131-8. 2008
    ..A prospective, randomized, double-blind, placebo-controlled crossover trial was performed for assessment of the safety and efficacy of niacinamide...
  98. ncbi Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008
    ....
  99. ncbi The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1
    Ying Wang
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Biol Chem 284:314-23. 2009
    ..Our findings support the hypothesis that pharmacologically targeting aging-associated proteins could help relieve age-dependent diseases...
  100. ncbi Occupational Mn parkinsonism: magnetic resonance imaging and clinical patterns following CaNa2-EDTA chelation
    G Discalzi
    Department of Occupational Health, Turin University, Italy
    Neurotoxicology 21:863-6. 2000
    ..These findings also agree with the few experimental and human studies published. This case study points to the need for an accurate occupational history collection and suggests the possibility of useful chelating therapy with CaNa2EDTA...
  101. ncbi EDTA chelation effects on urinary losses of cadmium, calcium, chromium, cobalt, copper, lead, magnesium, and zinc
    R S Waters
    Waters Preventive Medical Center Ltd, Wisconsin Dells, WI 53965, USA
    Biol Trace Elem Res 83:207-21. 2001
    ..These effects are likely to have significant effects on nutrient concentrations and interactions and partially explain the clinical improvements seen in patients undergoing EDTA chelation therapy...

Research Grants67

  1. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
    ..Approved chelating agents for severe plumbism are CaNa2EDTA (edetate disodium calcium) and succimer...
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  3. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ....
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..A successful agent will be highly useful invention not only for early detection of but also for following disease progression and as biomarker for assessing disease-modifying treatments for Alzheimer's disease. ..
  5. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..My project proposes to better understand the role of iron mobilization from lysosomes to mitochondria in ischemia/reperfusion injury and to develop novel therapies to mitigate or eliminate damage from this condition. ..
  6. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2011
    ..Finally, we propose formal collaboration with the Thalassemia clinical research network of the National Heart, Blood, and Lung Institute, to leverage the ongoing longitudinal screening in both networks. ..
  7. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..The information resulting from these investigations has a potential to provide clues to how HCV-induced oxidative stress and calcium signaling may induce profibrogenic factor, TGF-21, liver fibrosis and ultimately liver cancer. ..
  8. The role of trace metals and T-channels in pain
    Slobodan M Todorovic; Fiscal Year: 2013
    ....
  9. Mechanisms of Cell Death after Photodynamic Therapy
    Anna Liisa Nieminen; Fiscal Year: 2010
    ..The proposed studies will enhance our understanding how to enhance PDT-induced killing of cancer cells and further increase the efficacy of PDT translation to the benefit for cancer patients. ..
  10. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..An associated objective is to prepare zinc-selective, rapid chelating agents to be used in conjunction with investigations of the biological functions of mobile Zn2+...
  11. Neuroprotection by Mitochondria-targeted Antioxidants
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    ....
  12. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven L Spitalnik; Fiscal Year: 2012
    ....
  13. The role of dinitrosyliron complexes in cancer etiology
    Douglas D Thomas; Fiscal Year: 2013
    ..This has significance in regard to endogenous NO-producing tumors as well as NO-mediated chemotherapeutics. ..
  14. Extracellular Zinc Buffering and A-beta Oligomerization
    GUIDO FAAS; Fiscal Year: 2012
    ..With the acquired insight it should be possible to design drugs that specifically target pathological Zn2+ signals that may cause AD while minimally disturbing the Zn2+ signals necessary for normal brain functioning. ..
  15. Strategies for Heavy Metal Detoxification
    Gerard Parkin; Fiscal Year: 2013
    ..compounds that promote Hg-C bond cleavage in vivo, and which may be used in conjunction with traditional chelating agents. Both of these approaches are important because they represent significant advances over the methods ..
  16. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    ..The proposed research is expected to validate siderophore biosynthesis as new antibacterial target, which may lead to the development of a new class of antitubercular agents. ..
  17. Oxidative Stress in Oral Streptococci
    Robert E Marquis; Fiscal Year: 2010
    ..The work involves basic and applied studies Aimed at a better understanding of the biology of Dental plaque bacteria related especially to oxygen metabolism and damage caused by reactive oxygen species. ..
  18. New Strategies and Screening Methods for Metalloproteinase Inhibition
    Seth M Cohen; Fiscal Year: 2010
    ..This project seeks to discover selective metalloprotein inhibitors and develop a facile method by which the selectivity of these inhibitors can be rapidly assessed. ..
  19. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  20. Effect of Iron Chelators on HIV-1 transcription
    ZUFAN KEREGO DEBEBE; Fiscal Year: 2011
    ..These findings will provide information in the search for alternative therapeutic approaches that are hopefully more effective and efficient to treat HIV-1. Iron chelators could add to improve the treatment of HIV disease. ..
  21. Neuropathology of severe malaria in Thailand: MRI studies
    Gary M Brittenham; Fiscal Year: 2011
    ....
  22. Analysis of NGAL Metabolism Identifies a Therapy for Iron Overload
    Jonathan M Barasch; Fiscal Year: 2012
    ....
  23. Radiohybridization Imaging of HER2 Oncogene to Detect Breast Cancer
    Eric Wickstrom; Fiscal Year: 2010
    ..In the future, imaging multiple breast cancer genes might diagnose estrogen-dependent vs. estrogen-independent breast cancer without an invasive procedure. ..
  24. DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONS
    Roger Y Tsien; Fiscal Year: 2013
    ..Such tools will help elucidate mechanisms of neuronal information processing, communication, lifecycles, control of behavior, and pathological injury. ..
  25. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2013
    ..in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  26. Hepcidin Replacement Therapy for Iron Overload Disorders
    James W Larrick; Fiscal Year: 2013
    ..Routine treatment in an otherwise-healthy person consists of regularly scheduled phlebotomies or iron-chelating agents like deferoxamine...
  27. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf S Ibrahim; Fiscal Year: 2013
    ..Achieving these specific aims will further define the role of iron in the establishment and progression of mucormycosis and define possible novel therapeutic strategies that can be applied concurrently against the disease. ..
  28. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND JOSEPH BERGERON; Fiscal Year: 2013
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..
  29. Nephrogenic Systemic Fibrosis (NSF): A Rodent Model for Therapeutic Intervention
    Wassana Yantasee; Fiscal Year: 2013
    ....
  30. DERMATOREMEDIATION OF IRON OVERLOAD
    Leonard M Milstone; Fiscal Year: 2010
    ..Since iron is increasingly suspected of having a role in inflammatory and neoplastic diseases of skin, this new information should assist in devising preventative and treatment measures for those types of diseases. ..
  31. Salicylate production in siderophore biosynthesis
    Audrey L Lamb; Fiscal Year: 2012
    ..The goal of this work is to provide a fundamental understanding of two enzymes that promote virulence in P. aeruginosa so that this information can be exploited to generate new antimicrobial drugs. ..
  32. Therapeutics of XIAP Degradation by Zinc Chelators
    Vladimir M Kolenko; Fiscal Year: 2013
    ..To test our hypothesis and to evaluate the therapeutic uses of zinc chelating agents in prostate cancer, we propose the following Specific Aims: Aim 1: To identify 5-ALA derivatives with ..
  33. AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGING
    Lee E Goldstein; Fiscal Year: 2010
    ..The resulting data may provide insights into fundamental mechanisms of AD-associated protein aeration and support development of novel AD diagnostic and monitoring technology. ..
  34. Function and dysfunction of prion protein in cellular iron metabolism
    Neena Singh; Fiscal Year: 2010
    ..In the proposed studies we will test this hypothesis in cell models, and investigate whether iron chelation can be used as a therapeutic measure to alleviate prion disease associated neurotoxicity. ..
  35. The Use of Hyperthermia and Copper Chelation to Overcome Cisplatin Resistance
    CHELSEA DAWN LANDON; Fiscal Year: 2013
    ..Since cisplatin and copper chelators are currently both FDA approved drugs, our proposed treatment regime should have a relatively straightforward transition into the clinic. ..
  36. Novel Therapies for Enhancing Clearance of Inhaled Radioactive Particles
    KARL H DONN; Fiscal Year: 2010
    ..Insoluble particles cannot be systemically cleared by chelating agents as they are not in solution...
  37. LipoGels for Chelation of Transfusional Iron-Overload
    M PANG XIONG; Fiscal Year: 2013
    ....
  38. Biomimetic Actinide Decorporation: Characterization and Preclinical Development
    David K Shuh; Fiscal Year: 2010
    ..to reduce the dramatic health consequences of internal actinide/lanthanide contamination is treatment with chelating agents that form excretable complexes, although fission product lanthanides and the actinides are among the most ..
  39. Chelator Fragment Libraries for Optimizing Metal-Ligand Interactions in Metallopr
    Seth M Cohen; Fiscal Year: 2013
    ..These will be developed for the MMPs and CAs, as well as a variety of other metalloproteins of medicinal interest. ..
  40. Research for Adverse Drug-Events and Reports
    DENNIS PAUL WEST; Fiscal Year: 2010
    ..Fibrosis (NSF) is a disabling dermatologic adverse drug reaction associated with Gadolinium Containing Chelating Agents (GCCAs)...
  41. Zirconium-89: Radiochemistry and Ligand Design toward Improved PET Applications
    Melissa A Deri; Fiscal Year: 2013
    ..Beyond the research development, additional training will be provided in the form of coursework, seminars, professional conferences, mentoring opportunities, and career development. ..
  42. Structure-function analyses of siderophore biosynthetic enzymes
    Audrey L Lamb; Fiscal Year: 2013
    ..The goal of this work is to provide a fundamental understanding of four enzymes that promote virulence in P. aeruginosa so that this information can be exploited to generate new antimicrobial drugs. ..
  43. Mitochondria-targeted Agents in Breast Cancer
    Balaraman Kalyanaraman; Fiscal Year: 2013
    ..This research may potentially lead to novel ways for improving the therapeutic efficacy of DOX and other antitumor agents used in breast cancer treatment. ..
  44. The Coordination Chemistry of Nanocrystal Surfaces: Understanding the Role of Val
    BRANDI MICHELLE COSSAIRT; Fiscal Year: 2011
    ....
  45. Synthesis of new classes of metal ion chelators for therapeutic applications
    Aravamudan S Gopalan; Fiscal Year: 2013
    ..These conjugates can be then used as mechanistic probes to study iron transport or even as potential vehicles to deliver desired drugs into the organism. ..
  46. In vivo metal-free cycloaddition chemistry driven pretargeted cancer radiotherapy
    MARC ROBILLARD; Fiscal Year: 2013
    ..This project would be the first of it kind in vivo application of TCO-tetrazine cycloaddition chemistry with pretargeted ?-particle radiotherapy. ..
  47. Twice-Weekly Subcutaneous Liposome Chelator to Treat Transfusional Iron Overload
    MARK EAMON HAYES; Fiscal Year: 2013
    ..The formulation will be easier and safer to administer than Desferal(R). If LDFO is validated, it would be a significant advance for the clinical treatment of transfusional iron overload in pediatric patients. ..
  48. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..He also proposes to generate antibodies against specific dicarboxylic acid containing phospholipids. He will then determine whether such antibodies react against epitopes in oxidized LDL, plasma and atherosclerotic plaques. ..
  49. Use of Molecular Hydrogen by Salmonella typhimurium
    Robert J Maier; Fiscal Year: 2010
    ..Salmonella bacteria result in millions of cases of human diarrheal disease annually. Inhibiting growth of the bacterium within animal hosts is the long-term goal of this work. ..
  50. Comparative effectiveness of strategies to improve iron chelation in thalassemia
    Ellis J Neufeld; Fiscal Year: 2012
    ..Feedback from initial analyses in aim 2 will be used iteratively to improve Aim 1 logistics in anticipation of an R01 application in 2012. ..
  51. Calcium regulation of spontaneous release of GABA
    Courtney L Williams; Fiscal Year: 2013
    ..Understanding the mechanism by which Ca2+ influences release of neurotransmitter will contribute to an improved understanding of synaptic function in general and when transmission is disrupted in disease states. ..
  52. Influence of Iron on Murine Malaria
    David Joseph Sullivan; Fiscal Year: 2012
    ..Hematologic and immunologic biomarkers associated with outcome will be correlated ..
  53. Sperm DNA damage in fertilization
    MONIKA WARD; Fiscal Year: 2006
    ....
  54. Modulation of synaptic properties at the auditory Golgi-to-granule cell synapse
    DANIEL BOYD YAEGER; Fiscal Year: 2013
    ..Lastly, the effect of concurrent release o endogenous acetylcholine and glutamate on the Golgi-to-granule cell synapse will be determined. ..
  55. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    ..proposal will develop and evaluate novel biocompatible nanomaterials that will lead to a breakthrough in the field of chelation therapies of the above heavy metals by substantially outperforming the current FDA-approved chelating agents.
  56. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..The potential of identifying novel therapeutic targets to prevent or treat infections is also proposed. ..
  57. Hair Bundle Structure and Dynamics
    PETER GORDON BARR-GILLESPIE; Fiscal Year: 2013
    ..By moving towards relatively unbiased experimental approaches, we gain novel insights into structures critical for hearing and balance. ..
  58. BLOOD TISSUE IRON DEPLETION BY EXTRACORPOREAL CHELATOR
    CLARA AMBRUS; Fiscal Year: 1991
    ..She will then measure iron binding capacity of each of the above chelating agents in batch experiments...
  59. ACTION OF DMSA ON CELLULAR LEAD METABOLISM AND TOXICITY
    Joel Pounds; Fiscal Year: 1993
    ..Numerous studies have investigated the actions of chelating agents on lead metabolism in animals and humans, including selective removal from soft tissues and the skeleton, and ..
  60. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    ..New improved chelating agents for these metal ions have been designed...
  61. BACTERIAL METAL DETOXIFICATION--EXTRACELLULAR CHELATORS
    Andrew Gordon; Fiscal Year: 1991
    ..Human health implications of the research regard the environmental fate of potentially toxic heavy metals, and, therefore, mechanisms by which they may be incorporated into the food chain...
  62. THERAPEUTIC ROLE OF ANTIOXIDANTS IN LEAD POISONING
    Nuran Ercal; Fiscal Year: 2000
    ..Although chelating agents are currently available for the treatment of lead poisoning, they have been shown to have severe side effects...
  63. CHELATE CONJUGATED RADIOLABELED MONOCLONAL ANTIBODIES
    Richard Reba; Fiscal Year: 1990
    ..The biodistribution of the labeled antibodies and the tumor imaging will be investigated using rats with affinity beads localized in the lungs and nude mice implanted with human tumor xenografts...
  64. RECEPTOR MEDIATED UPTAKE OF IRON COMPLEXES IN BACTERIA
    MARK MCINTOSH; Fiscal Year: 1999
    ..Understanding the bacterial iron uptake process at a molecular level is therefore important to designing effective strategies to withhold this vital nutrient for potentially virulent organisms. ..
  65. NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALS
    Donald Buchsbaum; Fiscal Year: 2001
    ..This project focuses on the development of bifunctional chelating agents (BCAs), derived from the hydroxamic acid class of organic compounds, for radiometal labeling of MAbs with ..
  66. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2004
    ..low molecular weight ligands tends to be very slow, which severely restricts the ability of therapeutic iron chelating agents to target this readily accessible iron pool...
  67. Oral Radiation Nuclear Decorporation Agents
    Michael Jay; Fiscal Year: 2010
    The removal of certain internal radioactive contaminants can be accomplished by administering chelating agents that can preferentially complex with radionuclides in the body and increase their rate of clearance, thereby decreasing ..