chelating agents

Summary

Summary: Organic chemicals that form two or more coordination bonds with a central metal ion. Heterocyclic rings are formed with the central metal atom as part of the ring. Some biological systems form metal chelates, e.g., the iron-binding porphyrin group of hemoglobin and the magnesium-binding chlorophyll of plants. (From Hawley's Condensed Chemical Dictionary, 12th ed) They are used chemically to remove ions from solutions, medicinally against microorganisms, to treat metal poisoning, and in chemotherapy protocols.

Top Publications

  1. ncbi A randomized, double-blind, crossover design study of sevelamer hydrochloride and sevelamer carbonate in patients on hemodialysis
    J Delmez
    Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Nephrol 68:386-91. 2007
  2. pmc Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation
    Hsin Hung Chou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000652. 2009
  3. ncbi Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells
    Mohammad Hashemi
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
    Eur J Pharmacol 557:9-19. 2007
  4. doi Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease
    Garth J S Cooper
    Centre for Advanced Discovery and Experimental Therapeutics, NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, UK
    Drugs 71:1281-320. 2011
  5. ncbi Chelating agents in root canal treatment: mode of action and indications for their use
    M Hulsmann
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Gottingen, Germany
    Int Endod J 36:810-30. 2003
  6. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
  7. pmc Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
    Rodrigo B Oliveira
    Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 5:286-91. 2010
  8. pmc Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
  9. ncbi Chelators as antidotes of metal toxicity: therapeutic and experimental aspects
    Maja Blanusa
    Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, P O Box 291, HR 10001 Zagreb, Republic of Croatia
    Curr Med Chem 12:2771-94. 2005
  10. pmc Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
    Shuping Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 29:15277-85. 2009

Research Grants

Detail Information

Publications344 found, 100 shown here

  1. ncbi A randomized, double-blind, crossover design study of sevelamer hydrochloride and sevelamer carbonate in patients on hemodialysis
    J Delmez
    Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Nephrol 68:386-91. 2007
    ..The study investigated the effects of sevelamer carbonate and sevelamer hydrochloride on serum phosphorus, lipids and bicarbonate levels in hemodialysis patients...
  2. pmc Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation
    Hsin Hung Chou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000652. 2009
    ....
  3. ncbi Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells
    Mohammad Hashemi
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
    Eur J Pharmacol 557:9-19. 2007
    ..Interestingly, addition of Ca(2+), or Mg(2+) had no effect. The antioxidant N-Acetyl-L-Cysteine inhibited the cytotoxic effect of DTPA and TPEN, indicating that oxidative stress is the likely mediator of Zn-deficiency-related cell death...
  4. doi Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease
    Garth J S Cooper
    Centre for Advanced Discovery and Experimental Therapeutics, NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, UK
    Drugs 71:1281-320. 2011
    ....
  5. ncbi Chelating agents in root canal treatment: mode of action and indications for their use
    M Hulsmann
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Gottingen, Germany
    Int Endod J 36:810-30. 2003
    b>Chelating agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Østby...
  6. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
    ..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
  7. pmc Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
    Rodrigo B Oliveira
    Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 5:286-91. 2010
    ..This short-term 6-wk dose titration study evaluated the effect of two phosphate binders on PTH and FGF23 levels in patients with CKD stages 3 to 4...
  8. pmc Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
    ..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
  9. ncbi Chelators as antidotes of metal toxicity: therapeutic and experimental aspects
    Maja Blanusa
    Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, P O Box 291, HR 10001 Zagreb, Republic of Croatia
    Curr Med Chem 12:2771-94. 2005
    ..Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects...
  10. pmc Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
    Shuping Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 29:15277-85. 2009
    ..Our study suggests that the dynamic nature of the hair cell's transduction apparatus is retained despite the fact that regeneration of the hair bundle is lost in mammalian cochlear hair cells...
  11. pmc Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 21:1331-40. 2010
    ..The IMP467 peptide could be labeled up to 115 GBq/micromol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification...
  12. pmc Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    Tamara Isakova
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:584-91. 2011
    ..Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD...
  13. doi Antimicrobial activity of maleic acid and combinations of cetrimide with chelating agents against Enterococcus faecalis biofilm
    Carmen María Ferrer-Luque
    Department of Preventive and Operative Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 36:1673-5. 2010
    b>Chelating agents, such as EDTA or citric acid, can be incorporated into irrigants in order to provide different properties in a single compound...
  14. ncbi Analysis of renal impairment in children with Wilson's disease
    Xiao Hui Zhuang
    Department of Pediatrics, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    World J Pediatr 4:102-5. 2008
    ..This study was undertaken to find the clinical features of renal impairment in children with Wilson's disease or hepatolenticular degeneration (HLD)...
  15. ncbi Novel inhibitors of advanced glycation endproducts
    Samuel Rahbar
    Department of Diabetes, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Arch Biochem Biophys 419:63-79. 2003
    ....
  16. ncbi Heavy metal induced oxidative stress & its possible reversal by chelation therapy
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Indian J Med Res 128:501-23. 2008
    ..Chelation therapy with chelating agents like calcium disodium ethylenediamine tetra acetic acid (CaNa(2)EDTA), British Anti Lewisite (BAL), sodium 2,..
  17. pmc An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter
    C Thelwell
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle, NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 95:10728-33. 1998
    ..Metal coordination to His-imidazole and Cys-thiolate ligands at these residues of ZiaR is thus implicated in Zn2+-perception by Synechocystis PCC 6803...
  18. pmc Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis
    Yan Shou
    Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907 2091, USA
    Biochem J 379:805-13. 2004
    ..These observations show that by inducing a rapid increase in cytosolic free Ca2+, cyanide can partially initiate the apoptotic cascade through a calcineurin-mediated translocation of Bad to mitochondria...
  19. pmc Antioxidant and free radical scavenging activity of Spondias pinnata
    Bibhabasu Hazra
    Division of Molecular Medicine, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata 700054, India
    BMC Complement Altern Med 8:63. 2008
    ..Current research is directed towards finding naturally-occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of Spondias pinnata stem bark extract...
  20. ncbi Role of copper in tumour angiogenesis--clinical implications
    Anna Nasulewicz
    Laboratory of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, UI R Weigla 12, 53 114 Wroclaw, Poland
    J Trace Elem Med Biol 18:1-8. 2004
    ..The role of copper ions in tumour angiogenesis is discussed. The new antiangiogenic therapies based on a reduction of copper levels in tumour microenvironment are reviewed...
  21. ncbi Effects of chelating agents and sodium hypochlorite on mineral content of root dentin
    H Dogan
    Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Endod 27:578-80. 2001
    ..05). It was concluded that using NaOCl irrigation as final flush altered the effectiveness of chelating agents on root dentin.
  22. ncbi Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats
    Manisha Pande
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
    Toxicology 177:187-96. 2002
    ..in brain lead concentration in animals administered LA plus thiol chelators, compared to the effects of chelating agents alone. This is an interesting and notable observation, which requires further exploration...
  23. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  24. doi Zinc at glutamatergic synapses
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuroscience 158:126-36. 2009
    ..Finally, we present and compare two widely used zinc chelators, CaEDTA and tricine, and show why tricine should be preferred to CaEDTA when studying fast transient zinc elevations as may occur during synaptic activity...
  25. pmc Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  26. ncbi T-jump study of calcium binding kinetics of calcium chelators
    M Naraghi
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Cell Calcium 22:255-68. 1997
    ..EGTA and H-EDTA have small binding rate constants for calcium in the range of 3 x 10(6) M-1s-1 since, at pH 7.20, protons need to be dissociated from the chelators before they can bind calcium ions...
  27. ncbi Phytoremediation of soil metals
    R L Chaney
    United States Department of Agriculture, Beltsville Agricultural Research Center West, MD 20705, USA
    Curr Opin Biotechnol 8:279-84. 1997
    ....
  28. pmc Herpes simplex virus triggers activation of calcium-signaling pathways
    Natalia Cheshenko
    Deparment of Pediatrics and Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 163:283-93. 2003
    ..Defining the pathway of viral invasion may lead to new targets for anti-viral therapy...
  29. ncbi Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride
    Valerie Autissier
    School of Natural Sciences Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    J Pharm Sci 96:2818-27. 2007
    ..These findings indicate that LC binds phosphate more effectively than SH across the pH range encountered in the gastrointestinal tract, and has a lower propensity for bound phosphate to be displaced by competing anions in the intestine...
  30. ncbi Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+
    Y Li
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci 21:8015-25. 2001
    ..These results indicate that synaptically released Zn(2+), acting as a second messenger, is necessary for the induction of LTP at mossy fiber-->CA3 synapses of hippocampus...
  31. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  32. doi Wilson disease in children: analysis of 57 cases
    Nina Manolaki
    First Department of Pediatrics, Athens University, Aghia Sophia Children s Hospital, Athens, Greece
    J Pediatr Gastroenterol Nutr 48:72-7. 2009
    ..Affected children may be entirely asymptomatic and the diagnosis problematic. Herein we present the clinical and laboratory characteristics of 57 children with WD and point out the diagnostic difficulties in a pediatric population...
  33. ncbi Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes
    M Donadelli
    Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Verona, Italy
    J Cell Biochem 104:202-12. 2008
    ..In this study, we suggest that zinc depletion may be an efficient strategy in the treatment of pancreatic cancer because of its reduced antiproliferative effect on normal cells...
  34. pmc Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm
    Ehud Banin
    Box 357242, Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Appl Environ Microbiol 72:2064-9. 2006
    ..aeruginosa biofilms against EDTA treatment. Our results are consistent with a mechanism whereby EDTA causes detachment and killing of biofilm cells...
  35. pmc Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications
    Ryoji Nagai
    Department of Food and Nutrition, Japan Women s University, Tokyo, Japan
    Diabetes 61:549-59. 2012
    ..We conclude that chronic, low-dose chelation therapy deserves serious consideration as a clinical tool for prevention and treatment of diabetes complications...
  36. doi The pivotal role of intracellular calcium in oxaliplatin-induced inhibition of neurite outgrowth but not cell death in differentiated PC12 cells
    Miki Takeshita
    Department of Pharmacy Practice and Science, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Chem Res Toxicol 24:1845-52. 2011
    ..Therefore, it may be assumed that Ca/Mg is useful for protecting against oxaliplatin-induced neurotoxicity without reducing the antitumor activity of oxaliplatin...
  37. pmc Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 324:383-90. 2008
    ..Collectively, these data support a role for Mrp2 in the DMPS- and DMSA-mediated elimination of Hg(2+) from the kidney...
  38. doi In vitro binding of heavy metals by an edible biopolymer poly(gamma-glutamic acid)
    F Y Siao
    Department of Emergency Medicine, Changhua Christian Hospital, Taiwan
    J Agric Food Chem 57:777-84. 2009
    ..Incorporation of Cu, Zn, Fe, Mg, Ca, and K showed only a minor influence on lead binding but significantly reduced the binding of cadmium...
  39. ncbi Influence of root-surface conditioning with acid and chelating agents on clot stabilization
    Fabio Renato Manzolli Leite
    Department of Semilogy and Clinics, School of Dentistry, Federal University of Pelotas UFPel Pelotas, Rio Grande do Sul, Brazil
    Quintessence Int 41:341-9. 2010
    ..To compare the adhesion and maturation of blood components on chemically conditioned root surfaces...
  40. pmc Cellular responses to the metal-binding properties of metformin
    Lisa Logie
    Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 61:1423-33. 2012
    ..Together, these results suggest that cellular effects of biguanides depend on their metal-binding properties. This link may illuminate a better understanding of the molecular mechanisms enabling antihyperglycemic drug action...
  41. doi AMPK-independent induction of autophagy by cytosolic Ca2+ increase
    Antje Grotemeier
    Department of Internal Medicine I, University Clinic of Tubingen, Germany
    Cell Signal 22:914-25. 2010
    ..We suggest that apart from reported AMPK-dependent regulation of autophagic degradation, an AMPK-independent pathway triggers Ca(2+)-mediated autophagy, involving the PI(3)P-effector protein WIPI-1 and LC3...
  42. ncbi Chelate assisted phytoextraction of heavy metals from soil. Effect, mechanism, toxicity, and fate of chelating agents
    Michael W H Evangelou
    Institut für Biologie V, RWTH Aachen, Worringerweg 1, 52056 Aachen, Germany
    Chemosphere 68:989-1003. 2007
    ..The application of chelating agents has shown positive effects in increasing the solubility of heavy metals in soil and therefore in enhancing ..
  43. pmc p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging
    Lars R Perk
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:250-9. 2010
    ..To enable widespread use of (89)Zr-immuno-PET, we now introduce the novel BFC p-isothiocyanatobenzyl-desferrioxamine B (Df-Bz-NCS) and compare its performance in (89)Zr-immuno-PET with the reference BFC TFP-N-sucDf...
  44. pmc High-yielding aqueous 18F-labeling of peptides via Al18F chelation
    Christopher A D'Souza
    Immunomedics Inc, 300 American Road, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 22:1793-803. 2011
    ..These results demonstrate the facile application of Al(18)F chelation using BFC 1 as a versatile labeling method for radiofluorinating other heat-stable peptides for positron emission imaging...
  45. doi Lead-induced peripheral neuropathy following Ayurvedic medication
    Surjit Singh
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Sci 63:408-10. 2009
    ..He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal. The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning...
  46. ncbi Lanthanum carbonate vs. sevelamer hydrochloride for the reduction of serum phosphorus in hemodialysis patients: a crossover study
    S M Sprague
    NorthShore University Healthsystem, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Clin Nephrol 72:252-8. 2009
    ..The aim of this crossover study was to compare the reduction of serum phosphorus (SP) with fixed doses of the non-calcium-containing phosphate binders lanthanum carbonate (LC) and sevelamer hydrochloride (SH) in hemodialysis patients...
  47. pmc A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients
    Steven C Cheng
    Division of Nephrology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8129, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 3:1131-8. 2008
    ..A prospective, randomized, double-blind, placebo-controlled crossover trial was performed for assessment of the safety and efficacy of niacinamide...
  48. doi Assessment of survival in a 2-year comparative study of lanthanum carbonate versus standard therapy
    R Wilson
    Spica Consultants Ltd, Marlborough, UK
    Curr Med Res Opin 25:3021-8. 2009
    ..However, few studies have comprehensively evaluated the survival benefit associated with different phosphate binders. A post-hoc survival analysis was undertaken of lanthanum carbonate (Fosrenol *) versus standard therapy...
  49. ncbi Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine
    Maria J W D Vosjan
    Department of Otolaryngology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Protoc 5:739-43. 2010
    ..The entire process of pre-modification, radiolabeling and purification steps will take about 2.5 h...
  50. doi Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008
    ....
  51. doi Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Treat Rev 35:32-46. 2009
    ..Therefore, the elevated copper levels and increased oxidative stress in cancer cells provide for a prospect of selective cancer treatment...
  52. doi The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1
    Ying Wang
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Biol Chem 284:314-23. 2009
    ..Our findings support the hypothesis that pharmacologically targeting aging-associated proteins could help relieve age-dependent diseases...
  53. ncbi Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Arch Toxicol 76:269-76. 2002
    ....
  54. pmc Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity
    Satoru Yui
    Faculty of Pharmaceutical Sciences, Teikyo University, Tsukui gun, Kanagawa, Japan
    Mediators Inflamm 11:165-72. 2002
    ..We previously reported that rat calprotectin purified from inflammatory neutrophils induces apoptosis of various tumor cells or normal fibroblasts in a zinc-reversible manner...
  55. ncbi A comparative review of the efficacy and safety of established phosphate binders: calcium, sevelamer, and lanthanum carbonate
    Stuart M Sprague
    Division of Nephrology and Hypertension, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Curr Med Res Opin 23:3167-75. 2007
    ..Three major classes of phosphate binders include calcium-based binders, sevelamer HCl, and lanthanum carbonate...
  56. ncbi Regeneration of the heart in diabetes by selective copper chelation
    Garth J S Cooper
    Level 4, Thomas Building, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Diabetes 53:2501-8. 2004
    ..These data implicate accumulation of elevated loosely bound Cu in the mechanism of cardiac damage in diabetes and support the use of selective Cu chelation in the treatment of this condition...
  57. pmc Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study
    U Merle
    Department of Gastroenterology, University Hospital Heidelberg, Neuenheimer Feld 410, Heidelberg 69120, Germany
    Gut 56:115-20. 2007
    ..Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency...
  58. ncbi Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells
    M Adler
    Neurotoxicology Branch, Pharmacology Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Neurotoxicology 20:571-82. 1999
    ..Addition of an equimolar concentration of Zn2+ or Cu2+ but not Fe2+ or Mn2+ prevented morphological abnormalities and cell death...
  59. ncbi Clinical evaluation of a lead mobilization test using the chelating agent dimercaptosuccinic acid
    Perrine Hoet
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
    Clin Chem 52:88-96. 2006
    ..We propose a safe and convenient protocol for this test, to assess concomitant copper and zinc excretion and to determine the size of the chelatable lead pool in nonoccupationally exposed adults...
  60. ncbi Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination
    Helga Jurevics
    Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7250, USA
    J Neurochem 82:126-36. 2002
    ..The ability to correlate gene expression with known pathophysiological events should help in elucidating further function of such genes as related to demyelination/remyelination...
  61. ncbi Occupational Mn parkinsonism: magnetic resonance imaging and clinical patterns following CaNa2-EDTA chelation
    G Discalzi
    Department of Occupational Health, Turin University, Italy
    Neurotoxicology 21:863-6. 2000
    ..These findings also agree with the few experimental and human studies published. This case study points to the need for an accurate occupational history collection and suggests the possibility of useful chelating therapy with CaNa2EDTA...
  62. ncbi Chelating activity of advanced glycation end-product inhibitors
    D L Price
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
    J Biol Chem 276:48967-72. 2001
    ..Further, at therapeutic concentrations, the chelating activity of AGE inhibitors and AGE-breakers may contribute to their inhibition of AGE formation and protection against development of diabetic complications...
  63. ncbi EDTA chelation effects on urinary losses of cadmium, calcium, chromium, cobalt, copper, lead, magnesium, and zinc
    R S Waters
    Waters Preventive Medical Center Ltd, Wisconsin Dells, WI 53965, USA
    Biol Trace Elem Res 83:207-21. 2001
    ..These effects are likely to have significant effects on nutrient concentrations and interactions and partially explain the clinical improvements seen in patients undergoing EDTA chelation therapy...
  64. ncbi Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
    Saeid Ghavami
    Clinical Biochemistry Department, Faculty of Medical Sciences, Tarbiat Modaress University, P O BOX 14115 111, Tehran, I R, Iran
    J Leukoc Biol 76:169-75. 2004
    ....
  65. pmc Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS)
    H V Aposhian
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721 0106, USA
    Environ Health Perspect 106:1017-25. 1998
    ..Because South American animals studied were deficient in arsenite methyltransferase, a hypothesis is presented that arsenite and arsenite methyltransferase may have had a role in the evolution of some South American animals...
  66. ncbi Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms
    Toshio Miyata
    Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Am Soc Nephrol 13:2478-87. 2002
    ..This study provides a new framework for the assessment of families of AGE-lowering compounds according to their mechanisms of action...
  67. ncbi Cadmium therapeutic agents
    C Kelley
    Department of Chemistry, Northern Arizona University, Flagstaff, AZ 86011 5698
    Curr Pharm Des 5:229-40. 1999
    ..Preliminary attempts to combat acute cadmium poisoning included the use of the chelating agents ethylenediaminetetraacetic acid (EDTA) and British anti-Lewisite (BAL)...
  68. doi Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning
    Sally Bradberry
    West Midlands Poisons Unit, City Hospital, Birmingham, UK
    Clin Toxicol (Phila) 47:617-31. 2009
    ....
  69. ncbi Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Chem Biol Interact 145:267-80. 2003
    ..Thus, the co-administration of vitamin E during chelation treatment with DMSA or MiADMSA could be recommended for achieving optimum effects of chelation therapy...
  70. ncbi A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes
    D Gong
    School of Biological Sciences, Faculty of Science, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Diabetologia 51:1741-51. 2008
    ..Here, we report the effects of TETA treatment on Cu and other essential elements, as well as on indices of renal injury and known pathogenic molecular processes, in kidneys from a rat model of diabetes...
  71. ncbi Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats
    Sang Won Suh
    Department of Neurology, University of California at San Francisco, San Francisco, California, USA
    J Cereb Blood Flow Metab 29:1579-88. 2009
    ..Our data provide converging evidence in support of the essential role zinc has in modulating hippocampal neurogenesis...
  72. ncbi The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury
    James P K Rooney
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Toxicology 234:145-56. 2007
    ....
  73. ncbi Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Craig W Ritchie
    Departments of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Arch Neurol 60:1685-91. 2003
    ..Alzheimer disease (AD) may be caused by the toxic accumulation of beta-amyloid (Abeta)...
  74. ncbi Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon
    Christian Petzelt
    University Hospital Charite, Clinic for Anesthesiology and Intensive Care, Experimental Anesthesiology, FH 31, Spandauer Damm 130, 14050 Berlin, Germany
    Life Sci 72:1909-18. 2003
    ....
  75. ncbi Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice
    Tsvia Priel
    Department of Physiology and Zlotowski Center for Neurosciences, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Pharmacol 565:232-9. 2007
    ..Taken together, our results point to the potential utility of in vivo zinc chelation as a therapeutic strategy for treatment of idiopathic type I diabetes...
  76. ncbi Demyelination increases radial diffusivity in corpus callosum of mouse brain
    Sheng Kwei Song
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 26:132-40. 2005
    ..Radial diffusivity offers a specific assessment of demyelination and remyelination, as distinct from acute axonal damage...
  77. doi Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 001, India
    Biochem Pharmacol 78:1340-9. 2009
    ..We conclude that the ES-EB model seems to be an effective, faster, cost effective method for predicting efficacy of a drug...
  78. doi A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats
    Yuko Izuhara
    Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai, Japan
    Arterioscler Thromb Vasc Biol 28:1767-73. 2008
    ..Antihypertensive angiotensin II receptor blockers (ARBs) protect the kidney, at least in part, independently of blood pressure lowering. Still, the extent to which blood pressure lowering is related to renoprotection remains unclear...
  79. pmc A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Joseph F Quinn
    Portland Veterans Affairs Medical Center, P3 R and D, Portland, OR, USA
    J Alzheimers Dis 21:903-14. 2010
    ..Our data suggests that controlled lowering of systemic copper may achieve anti-amyloid effects if initiated early in the disease process...
  80. ncbi Preparation and study of new poly-8-hydroxyquinoline chelators for an anti-Alzheimer strategy
    Celine Deraeve
    Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
    Chemistry 14:682-96. 2008
    ..The Cu II and Zn II complexes include a fifth axial ligand and are pentacoordinated...
  81. ncbi Chelating agents for neurodegenerative diseases
    R J Ward
    Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Curr Med Chem 19:2760-72. 2012
    ..Copper and zinc homeostasis in brain and age associated changes are then outlined, along with a discussion of the possible involvement of Zn, Cu and Fe in Alzheimer's disease. We conclude with a brief summary of chelation therapy in AD...
  82. ncbi Environmental exposure to lead and progressive diabetic nephropathy in patients with type II diabetes
    J L Lin
    Division of Nephrology and Clinical Toxicology, Chang Gung Memorial Hospital, Lin Kou Medical Center, Taipei, Taiwan, ROC
    Kidney Int 69:2049-56. 2006
    ..We concluded that low-level environmental lead exposure accelerates progressive diabetic nephropathy and lead-chelation therapy can decrease its rate of progression...
  83. doi Effect of trientine on manganese intoxication in a patient with acquired hepatocerebral degeneration
    Hee K Park
    Mov Disord 23:768-70. 2008
  84. ncbi Fungal susceptibility to zinc deprivation
    Sarah J Lulloff
    Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, USA
    J Lab Clin Med 144:208-14. 2004
    ..These results suggest that marked susceptibility to zinc deprivation is a general characteristic of pathogenic fungi...
  85. ncbi Conjugation of chelating agents to proteins and radiolabeling with trivalent metallic isotopes
    Maggie S Cooper
    Nuclear Medicine Research Laboratory, St Bartholomew s Hospital, London EC1A 7BE, UK
    Nat Protoc 1:314-7. 2006
    ..As described in the protocol that follows, the entire conjugation, purification and labeling procedure takes about 2 d...
  86. ncbi Ca(2+) -independent effects of BAPTA and EGTA on single-channel Cl(-) currents in brown adipocytes
    Victor Sabanov
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91, Stockholm, Sweden
    Biochim Biophys Acta 1768:2714-25. 2007
    ..we attempted to control Ca(2+) levels at the cytoplasmic side of the inside-out membrane patches with Ca(2+)-chelating agents. However, we found that the commonly used Ca(2+)-chelators EGTA and BAPTA by themselves influenced the Cl(-) ..
  87. ncbi Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents
    Jose L Domingo
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, 43201 Reus, Spain
    J Alzheimers Dis 10:331-41. 2006
    ..The effects of desferrioxamine and other Al chelating agents have been reviewed...
  88. ncbi Autonomic dysfunction due to lead poisoning
    Kushal Madan
    Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar 110029, New Delhi, India
    Auton Neurosci 132:103-6. 2007
    ..At the 52nd week, most of the autonomic parameters had normalized except for the persistence of mild loss of parasympathetic reactivity...
  89. ncbi Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
    ..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
  90. ncbi The metal chelating and chaperoning effects of clioquinol: insights from yeast studies
    Chenghua Li
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing, China
    J Alzheimers Dis 21:1249-62. 2010
    ..We hope this regulation of metal homeostasis may be helpful in explaining the therapeutic effects of CQ used in disease treatment...
  91. ncbi The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells
    Qiang Tang
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Biochem Pharmacol 74:1596-607. 2007
    ..5 channels, though its efficacy is weaker than that of BAPTA-AM. These results indicate that the membrane permeable Ca(2+) chelator BAPTA-AM (also EGTA-AM) exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels...
  92. ncbi Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor
    H Vasken Aposhian
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona 85721 0106, USA
    J Toxicol Clin Toxicol 41:339-47. 2003
    ..Some medical practitioners prescribe GSH and vitamin C alone or in combination with DMPS or DMSA for patients with mercury exposure that is primarily due to the mercury vapor emitted by dental amalgams...
  93. pmc Bioavailability and uptake of lead by coffeeweed (Sesbania exaltata Raf.)
    Gloria Miller
    Plant Physiology Microbiology Laboratory, Department of Biology, P O Box 18540, College of Science, Engineering and Technology, Jackson State University, 1000 Lynch Street, Jackson, Mississippi 39217, USA
    Int J Environ Res Public Health 5:436-40. 2008
    ..Further, these results indicate that Sesbania exaltata can be grown under elevated Pb conditions and may be suitable as a potential crop rotation species for phytoextraction...
  94. ncbi NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging
    Patrick J Riss
    Institute of Nuclear Chemistry, University of Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem Lett 18:5364-7. 2008
    ..Protein binding and exemplified conjugation are also reported...
  95. pmc A randomized, crossover design study of sevelamer carbonate powder and sevelamer hydrochloride tablets in chronic kidney disease patients on haemodialysis
    Stanley Fan
    Department of Nephrology, Royal London Hospital, London, UK
    Nephrol Dial Transplant 24:3794-9. 2009
    ..This study compared the safety and efficacy of sevelamer carbonate powder with sevelamer hydrochloride tablets in CKD patients on haemodialysis...
  96. ncbi Quantifying the early stages of remyelination following cuprizone-induced demyelination
    Mark F Stidworthy
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Brain Pathol 13:329-39. 2003
    ..We also noted axonal pathology that persisted for at least 2 weeks after cuprizone withdrawal...
  97. ncbi [Use of the aluminum phosphate-binders in hemodialysis in the ultrapure water era]
    Maria D Arenas
    Hospital Perpetuo Socorro, Alicante
    Nefrologia 28:168-73. 2008
    ..The haemodialysis unit had a double osmosis inverse and the aluminium levels in haemodialysis liquid was less than 2 micrograms/liter...
  98. ncbi Water-elutability of nucleic acids from metal-chelate affinity adsorbents: enhancement by control of surface charge density
    Joseph Y Fu
    Department of Chemical Engineering, University of Houston, Houston, TX 77204 4004, USA
    J Mol Recognit 19:348-53. 2006
    ..Water elutability will significantly enhance the utility of IMAC in nucleic acid separations...
  99. doi Zinc monotherapy is not as effective as chelating agents in treatment of Wilson disease
    Karl Heinz Weiss
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Gastroenterology 140:1189-1198.e1. 2011
    ..Patients are treated with copper chelators and zinc salts, but it is not clear what approach is optimal because there have been few studies of large cohorts. We assessed long-term outcomes of different treatments...
  100. doi Wilson's disease: long-term follow-up of a cohort of 24 patients treated with D-penicillamine
    Klaartje F Lowette
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur J Gastroenterol Hepatol 22:564-71. 2010
    ..Detailed data on long-term effectiveness of various drug therapies in Wilson's disease (WD) are lacking. Therefore, we retrospectively reviewed our patient cohort treated with D-penicillamine...
  101. ncbi Deferoxamine as a chelator for 67Ga in the preparation of antibody conjugates
    Serengulam V Govindan
    Immunomedics, Inc, Morris Plains, NJ 07950, USA
    Nucl Med Biol 32:513-9. 2005
    ..In conclusion, DFO does not seem to be a suitable chelator for (67)Ga conjugation for our purposes...

Research Grants85

  1. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
    ..Approved chelating agents for severe plumbism are CaNa2EDTA (edetate disodium calcium) and succimer...
  2. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2009
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2010
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  4. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..A successful agent will be highly useful invention not only for early detection of but also for following disease progression and as biomarker for assessing disease-modifying treatments for Alzheimer's disease. ..
  6. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2009
    ..A successful agent will be highly useful invention not only for early detection of but also for following disease progression and as biomarker for assessing disease-modifying treatments for Alzheimer's disease. ..
  7. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ....
  8. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..He also proposes to generate antibodies against specific dicarboxylic acid containing phospholipids. He will then determine whether such antibodies react against epitopes in oxidized LDL, plasma and atherosclerotic plaques. ..
  9. Sperm DNA damage in fertilization
    MONIKA WARD; Fiscal Year: 2006
    ....
  10. Sperm DNA damage in fertilization
    MONIKA WARD; Fiscal Year: 2005
    ....
  11. Development of Chemical Tools to Probe and Inhibit Iron-Induced Oxidative Stress
    Katherine J Franz; Fiscal Year: 2010
    ..Our long-term goals are to develop medicinal iron chelating agents that selectively inhibit this deleterious iron-promoted damage at the site of oxidative stress while avoiding ..
  12. Development of Chemical Tools to Probe and Inhibit Iron-Induced Oxidative Stress
    Katherine Franz; Fiscal Year: 2009
    ..Our long-term goals are to develop medicinal iron chelating agents that selectively inhibit this deleterious iron-promoted damage at the site of oxidative stress while avoiding ..
  13. NATURE OF LEAD AND MERCURY BINDING NUCLEAR PROTEINS
    M Cherian; Fiscal Year: 1980
    ..toxic metals (lead and mercury), the role of these complexes in metal toxicity, and the effect of various chelating agents to remove the metals after formation of the protein-metal complexes...
  14. OXIDATIVE METABOLISM AND TRANSPORT IN RENAL TUBULES
    LAZARO MANDEL; Fiscal Year: 1990
    ..This knowledge will be used to attain our long term goal of developing the methodology to grow renal cells in monolayer culture that express normal oxidative metabolism...
  15. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2010
    ..The proposed research is expected to validate siderophore biosynthesis as new antibacterial target, which may lead to the development of a new class of antitubercular agents. ..
  16. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2010
    ..in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  17. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2011
    ..in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  18. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth Raymond; Fiscal Year: 2009
    ..in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  19. An Ftr1 vaccine to abrogate mucormycosis
    Ashraf S Ibrahim; Fiscal Year: 2010
    ..We propose to develop an antibody-based therapy that blocks the ability of the fungus to take up iron, thereby preventing its growth and improving the survival of infected patients. ..
  20. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2010
    ..Finally, we propose formal collaboration with the Thalassemia clinical research network of the National Heart, Blood, and Lung Institute, to leverage the ongoing longitudinal screening in both networks. ..
  21. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2007
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  22. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2009
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  23. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  24. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2009
    ..Moreover, this approach may be applied to other neurodegenerative diseases mediated by excess metals, and to neuro-imaging. ..
  25. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis Neufeld; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis Neufeld; Fiscal Year: 2009
    ..Finally, we propose formal collaboration with the Thalassemia clinical research network of the National Heart, Blood, and Lung Institute, to leverage the ongoing longitudinal screening in both networks. ..
  27. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    ..proposal will develop and evaluate novel biocompatible nanomaterials that will lead to a breakthrough in the field of chelation therapies of the above heavy metals by substantially outperforming the current FDA-approved chelating agents.
  28. DERMATOREMEDIATION OF IRON OVERLOAD
    LEONARD MILSTONE; Fiscal Year: 2007
    ..Since iron is increasingly suspected of having a role in inflammatory and neoplastic diseases of skin, this new information should assist in devising preventative and treatment measures for those types of diseases. ..
  29. DERMATOREMEDIATION OF IRON OVERLOAD
    LEONARD MILSTONE; Fiscal Year: 2006
    ..Since iron is increasingly suspected of having a role in inflammatory and neoplastic diseases of skin, this new information should assist in devising preventative and treatment measures for those types of diseases. ..
  30. DERMATOREMEDIATION OF IRON OVERLOAD
    LEONARD MILSTONE; Fiscal Year: 2009
    ..Since iron is increasingly suspected of having a role in inflammatory and neoplastic diseases of skin, this new information should assist in devising preventative and treatment measures for those types of diseases. ..
  31. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2003
    ..The potential of identifying novel therapeutic targets to prevent or treat infections is also proposed. ..
  32. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..The potential of identifying novel therapeutic targets to prevent or treat infections is also proposed. ..
  33. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. Chelators for Iron(III) for Therapeutic Uses and Probing Cellular Iron Transport
    ARAVAMUDAN GOPALAN; Fiscal Year: 2009
    ..The proposed work can have a significant positive impact on public health. ..
  35. Chelators for Iron(III) for Therapeutic Uses and Probing Cellular Iron Transport
    ARAVAMUDAN GOPALAN; Fiscal Year: 2009
    ..The proposed work can have a significant positive impact on public health. ..
  36. SIDEROPHORES, ANALOGS & BIOCONJUGATES: SYNTHESIS & STUDY
    Marvin Miller; Fiscal Year: 1991
    ....
  37. Chelators for Iron(III) for Therapeutic Uses and Probing Cellular Iron Transport
    Aravamudan S Gopalan; Fiscal Year: 2010
    ..The proposed work can have a significant positive impact on public health. ..
  38. ACTION OF DMSA ON CELLULAR LEAD METABOLISM AND TOXICITY
    Joel Pounds; Fiscal Year: 1993
    ..Numerous studies have investigated the actions of chelating agents on lead metabolism in animals and humans, including selective removal from soft tissues and the skeleton, and ..
  39. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2010
    ..An associated objective is to prepare zinc-selective, rapid chelating agents to be used in conjunction with investigations of the biological functions of mobile Zn2+...
  40. ACTION OF DMSA ON CELLULAR LEAD METABOLISM AND TOXICITY
    Joel Pounds; Fiscal Year: 1991
    ..Numerous studies have investigated the actions of chelating agents on lead metabolism in animals and humans, including selective removal from soft tissues and the skeleton, and ..
  41. BLOOD TISSUE IRON DEPLETION BY EXTRACORPOREAL CHELATOR
    CLARA AMBRUS; Fiscal Year: 1991
    ..She will then measure iron binding capacity of each of the above chelating agents in batch experiments...
  42. Functional role of vesicular zinc in synaptic mechanisms in the amygdala
    Vadim Bolshakov; Fiscal Year: 2010
    ....
  43. Phosphinimine Conjugates for Tc(Vll) Stabilization in Labeling Peptides
    Kattesh Katti; Fiscal Year: 2003
    ..Development of functional and adaptable chelating agents and optimization of bioconjugation strategies, toward functionalization of BFCAs (or the radiolabeled BFCs), ..
  44. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    ..New improved chelating agents for these metal ions have been designed...
  45. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2000
    ..New improved chelating agents for these metal ions have been designed...
  46. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1999
    ..New improved chelating agents for these metal ions have been designed...
  47. MECHANISMS FOR OXIDATIVE STRESS INDUCED APOPTOSIS
    KATHRYN HELD; Fiscal Year: 1999
    ..g., to enhance cell killing in tumor cells or prevent cell killing in AIDS, autoimmune diseases, neurodegenerative diseases, etc., where oxidative stress may play a role. ..
  48. Biomimetic Actinide Decorporation: Characterization and Preclinical Development
    David K Shuh; Fiscal Year: 2010
    ..to reduce the dramatic health consequences of internal actinide/lanthanide contamination is treatment with chelating agents that form excretable complexes, although fission product lanthanides and the actinides are among the most ..
  49. Biomimetic Actinide Decorporation: Characterization and Preclinical Development
    Kenneth Raymond; Fiscal Year: 2009
    ..to reduce the dramatic health consequences of internal actinide/lanthanide contamination is treatment with chelating agents that form excretable complexes, although fission product lanthanides and the actinides are among the most ..
  50. BACTERIAL METAL DETOXIFICATION--EXTRACELLULAR CHELATORS
    Andrew Gordon; Fiscal Year: 1991
    ..Human health implications of the research regard the environmental fate of potentially toxic heavy metals, and, therefore, mechanisms by which they may be incorporated into the food chain...
  51. THERAPEUTIC ROLE OF ANTIOXIDANTS IN LEAD POISONING
    Nuran Ercal; Fiscal Year: 2000
    ..Although chelating agents are currently available for the treatment of lead poisoning, they have been shown to have severe side effects...
  52. New Strategies and Screening Methods for Metalloproteinase Inhibition
    Seth Cohen; Fiscal Year: 2009
    ..This project seeks to discover selective metalloprotein inhibitors and develop a facile method by which the selectivity of these inhibitors can be rapidly assessed. ..
  53. New Strategies and Screening Methods for Metalloproteinase Inhibition
    Seth M Cohen; Fiscal Year: 2010
    ..This project seeks to discover selective metalloprotein inhibitors and develop a facile method by which the selectivity of these inhibitors can be rapidly assessed. ..
  54. CHELATE CONJUGATED RADIOLABELED MONOCLONAL ANTIBODIES
    Richard Reba; Fiscal Year: 1990
    ..The biodistribution of the labeled antibodies and the tumor imaging will be investigated using rats with affinity beads localized in the lungs and nude mice implanted with human tumor xenografts...
  55. RECEPTOR MEDIATED UPTAKE OF IRON COMPLEXES IN BACTERIA
    MARK MCINTOSH; Fiscal Year: 1999
    ..Understanding the bacterial iron uptake process at a molecular level is therefore important to designing effective strategies to withhold this vital nutrient for potentially virulent organisms. ..
  56. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1993
    ..In this proposal it is planned to design, synthesize and study new, improved chelating agents for the complexation of these metal ions...
  57. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1992
    ..In this proposal it is planned to design, synthesize and study new, improved chelating agents for the complexation of these metal ions...
  58. NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALS
    Donald Buchsbaum; Fiscal Year: 2001
    ..This project focuses on the development of bifunctional chelating agents (BCAs), derived from the hydroxamic acid class of organic compounds, for radiometal labeling of MAbs with ..
  59. NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALS
    Donald Buchsbaum; Fiscal Year: 2000
    ..This project focuses on the development of bifunctional chelating agents (BCAs), derived from the hydroxamic acid class of organic compounds, for radiometal labeling of MAbs with ..
  60. NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALS
    Donald Buchsbaum; Fiscal Year: 1999
    ..This project focuses on the development of bifunctional chelating agents (BCAs), derived from the hydroxamic acid class of organic compounds, for radiometal labeling of MAbs with ..
  61. A device containing an immobilized chelator to remove aluminum from total parente
    ROBERT ALLEN YOKEL; Fiscal Year: 2010
    ..This will remove the potential for Al to produce toxicity to premature infants and other patients who are exposed to Al through intravenous fluids, solving a decades-old problem that has escaped resolution to date. ..
  62. Lipoate Derivatives Targeting Alzheimer's Amyloid
    Xudong Huang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. CARDIAC DISEASE IN COOLEYS ANEMIA--MOLE AND CLIN STUDIES
    Gary Brittenham; Fiscal Year: 2001
    ....
  64. FACTORS REGULATING THE CELLULAR UPTAKE OF IRON
    Jerry Kaplan; Fiscal Year: 1990
    ..These studies will yield information on the mechanisms of tissue iron overload and the role of iron in normal and pathological processes...
  65. FACTORS REGULATING THE CELLULAR UPTAKE OF IRON
    Jerry Kaplan; Fiscal Year: 1993
    ..These studies will yield information on the mechanisms of tissue iron overload and the role of iron in normal and pathological processes...
  66. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2004
    ..low molecular weight ligands tends to be very slow, which severely restricts the ability of therapeutic iron chelating agents to target this readily accessible iron pool...
  67. CARDIAC DISEASE IN COOLEYS ANEMIA--MOLE AND CLIN STUDIES
    Gary Brittenham; Fiscal Year: 1999
    ....
  68. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2000
    ..low molecular weight ligands tends to be very slow, which severely restricts the ability of therapeutic iron chelating agents to target this readily accessible iron pool...
  69. CARDIAC DISEASE IN COOLEYS ANEMIA--MOLE AND CLIN STUDIES
    Gary Brittenham; Fiscal Year: 2000
    ....
  70. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2002
    ..low molecular weight ligands tends to be very slow, which severely restricts the ability of therapeutic iron chelating agents to target this readily accessible iron pool...
  71. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2009
    ..We aim to develop strong-binding radiometal carriers to ensure safe delivery of copper, gallium, and indium radioisotopes for both diagnosis and treatment of cancer. ..
  72. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward H Wong; Fiscal Year: 2010
    ..We aim to develop strong-binding radiometal carriers to ensure safe delivery of copper, gallium, and indium radioisotopes for both diagnosis and treatment of cancer. ..
  73. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2007
    ..We aim to develop strong-binding radiometal carriers to ensure safe delivery of copper, gallium, and indium radioisotopes for both diagnosis and treatment of cancer. ..
  74. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2009
    ..We aim to develop strong-binding radiometal carriers to ensure safe delivery of copper, gallium, and indium radioisotopes for both diagnosis and treatment of cancer. ..
  75. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2006
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..
  76. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2005
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..
  77. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND JOSEPH BERGERON; Fiscal Year: 2010
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..
  78. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2005
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..
  79. BIOLOGICAL EVALUATION OF NEW ACTINIDE-CHELATING AGENTS
    Patricia Durbin; Fiscal Year: 1993
    ..The only known way to reduce cancer risk is acceleration of actinide excretion with chelating agents. The goal of this research is to develop low toxicity ligands, more effective for in vivo actinide chelation ..
  80. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2007
    ..Physicians have a pressing clinical need for new, more effective iron-chelating agents which selectively remove iron from the liver, heart, and pancreas, the organs at greatest risk of iron-..