Summary: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
Publications135 found, 100 shown here
- [Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa]S Knipping
Universitätsklinik und Poliklinik für Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie, Martin Luther Universitat Halle Wittenberg
HNO 54:742-8. 2006..Nasal obstruction is caused by rebound swelling when the decongestive effect has disappeared. The patient starts using nasal drops more frequently as a result of tachyphylaxis...
- Relationship between rhinitis duration and response to nasal decongestion testGiorgio Ciprandi
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
Laryngoscope 118:1139-41. 2008..The purpose of the study was to evaluate the impact of the duration of rhinitis on the response to nasal decongestion test in a cohort of patients with PER...
- Comparison of the clinical efficacy of standard and mucoadhesive-based nasal decongestantsChristo T Tzachev
Department of Industrial Pharmacy, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Br J Clin Pharmacol 53:107-9. 2002..It also caused fewer side effects...
- alpha2-adrenoceptor agonists as nasal decongestantsM R Corboz
Pulmonary and Peripheral Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Pulm Pharmacol Ther 20:149-56. 2007....
- Nasal decongestants in the treatment of chronic nasal obstruction: efficacy and safety of useDesiderio Passali
Chief Professor, ENT Clinic University of Siena Medical School, Policlinico Le Scotte Viale Bracci, 53100 Siena, Italy
Expert Opin Drug Saf 5:783-90. 2006b>Nasal decongestants are the most powerful drugs in the reduction of nasal obstruction. Despite their large use, local and systemic adverse reactions are frequent...
- Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitisGiorgio Ciprandi
Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
Am J Rhinol 22:502-5. 2008..The aim of this study was to verify the suitability of the use of the visual analog scales (VASs) as a surrogate for rhinomanometry in the decongestion test assessment in patients with persistent allergic rhinitis...
- Pediatric allergic rhinitis: treatmentLien Lai
Department of Medicine, Creighton University Medical Center, 601 North 30th Street, Suite 5850, Omaha, NE 68131 USA
Immunol Allergy Clin North Am 25:283-99, vi. 2005..Immunotherapy generally is reserved for patients unresponsive to therapy or unable to take medications...
- Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus budesonide nasal spray in the management of nasal congestion in allergic rhinitisUrsula P Zieglmayer
ENT - University Clinic Vienna, Vienna, Austria
Treat Respir Med 4:283-7. 2005..Both medications were well-tolerated. Cetirizine/pseudoephedrine was more effective than budesonide during HDM exposure, whereas budesonide became as effective as cetirizine/pseudoephedrine several hours post exposure to the allergens...
- The value of Ems Mineral Salts in the treatment of rhinosinusitis in children. Prospective study on the efficacy of mineral salts versus xylometazoline in the topical nasal treatment of childrenO Michel
Klinik u Poliklinik für HNO Heilkunde, Klinikum der Universität zu Köln, Kerpenerstr 62, 50924 Köln, Germany
Int J Pediatr Otorhinolaryngol 69:1359-65. 2005..a treatment with xylometazoline, but with the distinction that with EMS the length of use was not restricted, there were not the potential side effects of nasal decongestants, and there was no contraindication in the newborn and infants.
- Nasal wall compliance in vasomotor rhinitisJean François Papon
Physiopathologie et Thérapeutique Respiratoires INSERM UMR 651, Creteil, France
J Appl Physiol 100:107-11. 2006....
- Comparison of decongestive capacity of xylometazoline and pseudoephedrine with rhinomanometry and MRIM Caenen
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Free University Brussels, Brussels, Belgium
Rhinology 43:205-9. 2005..However, there was no decongestive effect whatsoever on the mucosa of the sinuses with either sympathicomimetic...
- [Investigation of the effect of oxymetazoline on the duration of rhinitis]S Reinecke
MMW Fortschr Med 147:46. 2005
- Improving the management and quality of life of patients with allergic rhinitisVictoria Carr
National Heart and Lung Institute, Imperial College London
Prof Nurse 20:31-3. 2005..This paper looks at the main causes of allergic rhinitis and its symptoms, and describes the available treatments to manage the conditon...
- Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatographyXiaochen Gu
Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2
J Pharm Biomed Anal 37:663-7. 2005..This method was used to assay various samples from studies of the commercial preparation Semprex-D capsules. The method was found to be accurate, specific, selective, rapid, and versatile for use in routine quality control analyses...
- [Acute exposure to imidazoline derivatives in children]Fabio Bucaretchi
Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
J Pediatr (Rio J) 79:519-24. 2003..To study acute exposure to imidazoline derivatives in 72 children younger than 15 years of age, followed-up from January 1994 to December 1999...
- Characterization of nasal obstruction in the allergic guinea pig using the forced oscillation methodRobbie L McLeod
Department of Allergy, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 0539, USA
J Pharmacol Toxicol Methods 48:153-9. 2002..This is the first report to evaluate changes in nasal resistance in a preclinical animal model using the forced oscillation method...
- Intranasal drug delivery: an alternative to intravenous administration in selected emergency casesTimothy R Wolfe
Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, USA
J Emerg Nurs 30:141-7. 2004
- Control of nasal obstruction in perennial allergic rhinitisDe Yun Wang
Department of Otolaryngology, Faculty of Medicine, National University of Singapore
Curr Opin Allergy Clin Immunol 4:165-70. 2004..Nasal obstruction in persistent allergic rhinitis must be treated the year round, and therefore treatment choices, costs, and compliance all become important public health issues...
- [Pathologic conditions associated with drug-induced rhinitis]Dusanka Milosević
Zvezdara Department of Otorhinolaryngology, University Hospital Centre, Belgrade
Srp Arh Celok Lek 132:14-7. 2004..In conclusion, the most common pathological conditions for developing rhinitis medicamentosa were chronic inflammatory and structural diseases manifested by permanent nasal obstruction as well as acute upper respiratory infections are...
- Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal sprayAndrea H S Loewen
Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alta
CMAJ 171:593-4. 2004Oxymetazoline is a sympathomimetic amine found in over-the-counter nasal decongestants. We report a case of chronic use of nasal oxymetazoline associated with thunderclap headache due to reversible segmental intracranial vasoconstriction.
- Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitisWilliam W Storms
University of Colorado Health Sciences Center, Colorado Springs, CO, USA
J Allergy Clin Immunol 114:S146-53. 2004..Because of the significant detrimental effects of nocturnal rhinitis symptoms on quality of life, allergic rhinitis therapies should be evaluated for efficacy in ameliorating nighttime symptoms...
- Effect of treating severe nasal obstruction on the severity of obstructive sleep apnoeaH A McLean
Dept of Medicine, Queen's University, 102 Stuart Street, Kingston, ON K7L 3N6, Canada
Eur Respir J 25:521-7. 2005..In conclusion, treating nasal obstruction reduced mouth breathing during sleep and obstructive sleep apnoea severity, but did not effectively alleviate obstructive sleep apnoea...
- [Efficacy of Derinox assessed with one PNIF (Peak Nasal Inspiratory Flow) in patients suffering from common cold]R Peynegre
, , France
Ann Otolaryngol Chir Cervicofac 122:246-55. 2005..CONCLUSION: Efficacy of DÃ©rinox(R) was superior to that of P and R for the improvement of the nasal obstruction (PNIF) between T0 and T3h (main criteria) after the first intake in patients suffering from common cold...
- Rhinitis medicamentosa: therapeutic effect of diode laser inferior turbinate reduction on nasal obstruction and decongestant abusePhilipp P Caffier
Department of Otorhinolaryngology, Head and Neck Surgery Charité University Medicine Berlin, Berlin, Germany
Am J Rhinol 22:433-9. 2008..The purpose of this study was to evaluate long-term outcomes of an outpatient-based diode laser inferior turbinate reduction (ITR) in therapy-refractory rhinitis medicamentosa (RM)...
- Sublingual immunotherapy-induced IL-10 production is associated with changed response to the decongestion test: preliminary resultsGiorgio Ciprandi
A O U San Martino, Genoa, Italy
Allergy Asthma Proc 28:574-7. 2007..0016 and p = 0.00294, respectively). This preliminary study provides the first evidence of a changed response to decongestion testing after SLIT that is associated with IL-10 production in patients with PAR...
- Topical treatment of rhinosinusitisA Fiocchi
Melloni Paediatria and the Fatebenefratelli Hospital, Melloni, Milan, Italy
Pediatr Allergy Immunol 18:62-7. 2007..While saline irrigation, nasal decongestants, steroids, antibiotics, antihistamines and fungicides are all in widespread pediatric use, comparing ..
- Office-based management of allergic rhinitis in adultsJeffrey M Lehman
Department of Allergy and Immunology, University of Tennessee Health Science Center, Memphis, Tenn, USA
Am J Med 120:659-63. 2007..Controlled studies support the utility of several available treatments that produce fewer symptoms, improve quality of life, and prevent comorbidities...
- Nasal eosinophils and reversibility to the decongestion test in patients with perennial allergic rhinitisGiorgio Ciprandi
Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
Allergy Asthma Proc 28:292-5. 2007..338). This study provides evidence of a significant association between nasal eosinophils and the reversibility to the decongestion test in patients with PAR...
- Sinonasal disease and nasal salineBaran Acar
Arch Otolaryngol Head Neck Surg 133:625; author reply 625. 2007
- Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relieving symptoms of acute nasopharyngitis in children? A randomised, controlled trialEmin Unuvar
Department of Pediatrics, Istanbul University, Istanbul Medical Faculty, Capa, TR 34390, Istanbul, Turkey
Int J Pediatr Otorhinolaryngol 71:1277-85. 2007..To determine the efficiency of drugs, which include antihistaminic-decongestant-acetaminophen agents versus only acetaminophen in symptomatic treatment of acute nasopharyngitis in children...
- Reference values for acoustic rhinometry in decongested school children and adults: the most sensitive measurement for change in nasal patencySune P Straszek
Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Aarhus, Denmark
Rhinology 45:36-9. 2007..We want to establish a set of reference values for MCA and nasal volumes for both adults and children and include values also for the decongested nose and determine the most sensitive measurement for change in nasal patency...
- Allergic rhinitis: selective comparisons of the pharmaceutical options for managementBob Lanier
Department of Pediatrics Immunology, University of North Texas, Fort Worth, USA
Allergy Asthma Proc 28:16-9. 2007..This review is intended as an aid in comparing classes and formats of medications affecting nasal allergy...
- Treatment of acute and chronic rhinosinusitis in the United States, 1999-2002Hadley J Sharp
Department of Otolaryngology Head and Neck Surgery, University of Nebraska Medical Center, Omaha 68106, USA
Arch Otolaryngol Head Neck Surg 133:260-5. 2007....
- Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitroNorbert Klöcker
AUDIT Institute for Medical Services and Quality Assurance, Taunusstein, Germany
Am J Rhinol 18:315-20. 2004More than 600 million units of nasal decongestants are sold worldwide annually...
- A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulationsMohammed Shahid Ali
Jamjoom Pharmaceuticals Company Limited, Industrial Area, Phase 5, Jeddah 21442, Saudi Arabia
J Pharm Biomed Anal 43:158-67. 2007..Mobile phase pH is manipulated to regulate ionization and ion-exchange interaction and thereby retention of compounds...
- Decongestion test in patients with allergic rhinitis: functional evaluation of nasal airflowGiorgio Ciprandi
Ospedale San Martino, Genoa, Italy
Am J Rhinol 20:224-6. 2006....
- Medical management and diagnosis of chronic rhinosinusitis: A survey of treatment patterns by United States otolaryngologistsScott M Kaszuba
Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas, USA
Am J Rhinol 20:186-90. 2006..S. otolaryngologists agree on the use of oral antibiotics and nasal corticosteroids as part of maximal medical management for CRS but do not agree on other adjuvant therapies or on the use of endoscopy as a diagnostic criterion...
- Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitisGordon D Raphael
Pfizer Consumer Healthcare, Morris Plains, New Jersey 07950, USA
Ann Allergy Asthma Immunol 96:606-14. 2006..Somnolence occurred more frequently with diphenhydramine (22.1%) compared with desloratadine (4.5%) and placebo (3.4%)...
- Association between response to decongestion testing and sensitizations and allergic inflammationGiorgio Ciprandi
Dipartimento Patologie Testa Collo, Padiglione Specialità piano terzo, Azienda Ospedale Università San Martino, Genoa, Italy
Ann Allergy Asthma Immunol 96:431-6. 2006..Rhinomanometry is used to measure nasal airflow, which is frequently impaired in allergic rhinitis (AR). Decongestion testing consists of spraying an intranasal vasoconstrictor drug to evaluate recovery of nasal airflow...
- [The tolerability of nasal drugs with special regard to preservatives and physico-chemical parameters]Th Verse
Universitäts Hals Nasen Ohrenklinik Mannheim
Laryngorhinootologie 82:782-9. 2003..New pharmaceutical formulations for better tolerable nasal sprays are now possible and consequently reformulations introduced to the market. Therefore, a representative and systematic overview on comparable products is mandatory...
- Intranasal application of the alpha2-adrenoceptor agonist BHT-920 produces decongestion in the catR L McLeod
Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA
Am J Rhinol 15:407-15. 2001..3 and 1.0% lasted over 60 minutes. The present findings indicate that selective alpha2-agonists may produce decongestant activity with an improved cardiovascular profile compared with current sympathomimetic drugs such as phenylephrine...
- Pregnancy rhinitis and rhinitis medicamentosaBetty Rambur
College of Nursing and Health Sciences, University of Vermont in Burlington, VT, USA
J Am Acad Nurse Pract 14:527-30. 2002..To present guidelines for the recognition, management, and referral of pregnancy rhinitis with a goal of improving the quality of the pregnancy experience for women afflicted with this condition...
- Canine model of nasal congestion and allergic rhinitisRuslan L Tiniakov
University of Illinois at Chicago, and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612, USA
J Appl Physiol 94:1821-8. 2003....
- Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus xylometazoline nasal spray in nasal congestionU P Stübner
Ear Nose Throat University Clinic, Vienna, Austria
Arzneimittelforschung 51:904-10. 2001..With the exception of nasal obstruction, all subjective symptoms as well as the global condition were significantly better under CTZ/PSE. Amounts of nasal secretions during these sessions were significantly lower with CTZ/PSE...
- [The relationship between ostial patency and medical treatment in acute maxillary sinusitis: an experimental study]Ahmet Kutluhan
Department of Otolaryngology, Medicine Faculty of Yüzüncü Yıl University, Van, Turkey
Kulak Burun Bogaz Ihtis Derg 9:275-81. 2002..We investigated the relationship between ostial patency and medical treatment in an experimental model of acute maxillary sinusitis...
- Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unitRobert B Berkowitz
RxResearch, Woodstock, Georgia 30188, USA
Ann Allergy Asthma Immunol 89:38-45. 2002..4% for fexofenadine-pseudoephedrine and 3.3% for placebo. CONCLUSIONS: Fexofenadine-pseudoephedrine was safe and effective in treating a broad range of allergy symptoms, with a rapid onset of action at 45 minutes...
- Improved strategies and new treatment options for allergic rhinitisSandra K Willsie
University of Health Sciences College of Osteopathic Medicine in Kansas City, MO, USA
J Am Osteopath Assoc 102:S7-14. 2002..Future therapeutic options include leukotriene modifiers and anti-IgE antibodies...
- Decongestant activity of a new formulation of xylometazoline nasal spray: a double-blind, randomized versus placebo and reference drugs controlled, dose-effect studyF Castellano
IBSA Institut Biochimique S.A, 6915 Pambio-Noranco, Switzerland
Drugs Exp Clin Res 28:27-35. 2002..1%. HA seems to act as an enhancer/carrier of the active principle, xylometazoline, as already demonstrated for other drugs. The new formulation at a concentration of 0.05% was therefore selected for further clinical development...
- Hypertonic saline nasal provocation and acoustic rhinometryJ N Baraniuk
Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC 20007, USA
Clin Exp Allergy 32:543-50. 2002..Hypertonic saline (HTS) acts as an airway irritant in human nasal mucosa by stimulating nociceptive nerves and glandular secretion. HTS does not change vascular permeability. In asthma, HTS causes airflow obstruction...
- The effect of intranasal budesonide spray on mucosal blood flow measured with laser Doppler flowmetryA Cervin
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Lund, S-221 85 Lund, Sweden
Rhinology 39:13-6. 2001..9 +/- 7.1% measured from baseline values. CONCLUSION: A single dose of intranasal budesonide aqueous nasal spray has no acute effects on nasal septal mucosal blood flow...
- The effect of inferior turbinate hypertrophy on nasal spray distribution to the middle meatusA C Dowley
Department of Otolaryngology-Head and Neck Surgery, Hull Royal Infirmary, Hull, UK
Clin Otolaryngol Allied Sci 26:488-90. 2001..026). This may support a clinical role for inferior turbinate reduction to improve the efficacy of topical nasal therapy, as well as improving nasal airflow...
- [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis]W Kehrl
Klinik und Ambulatorium für Hals Nasen Ohren Krankenheiten, Katholisches Marienkrankenhaus, Hamburg
Laryngorhinootologie 82:266-71. 2003..After proving a synergistic effect of Xylometazoline and Dexpanthenol (Nasic) in patients after nasal surgery, this result should be checked in patients with acute non-allergic rhinitis...
- Chronic cough. Article is not consistent with WHO initiative on rhinitis and asthmaMike Thomas
BMJ 326:1036. 2003
- Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spraySandra Gawchik
Asthma and Allergy Associates, Upland, Pennsylvania, USA
Ann Allergy Asthma Immunol 90:416-21. 2003..Mometasone furoate nasal spray (MFNS, Nasonex, Schering, Kenilworth, NJ), an anti-inflammatory nasal corticosteroid, has been shown to be safe and effective in reducing the nasal inflammation of SAR...
- [Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis]M Dorn
Casore del Monte, Toscana-Italien
HNO 51:794-9. 2003..CONCLUSION. Preparations without preservatives should be the preferred choice of treatment for acute rhinitis...
- Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park studyEli O Meltzer
Allergy and Asthma Medical Group and Research Center, San Diego, California, USA
Ann Allergy Asthma Immunol 90:79-86. 2003..Patients with allergic rhinitis have a wide range of symptoms that are often treated with oral combination products that contain antihistamines, decongestants, and analgesics...
- Allergic rhinoconjunctivitis in elite athletes: optimal management for quality of life and performanceConstance H Katelaris
Institute of Immunology and Allergy Research, Westmead Hospital, Westmead 2145, Sydney, New South Wales, Australia
Sports Med 33:401-6. 2003..Since avoidance strategies are rarely practical for the athlete, consideration should be given to strategies such as immunotherapy, where long-term benefit is possible...
- The vascular effects of trace amines and amphetaminesKenneth J Broadley
Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, UK
Pharmacol Ther 125:363-75. 2010..This effect is the basis of their use as nasal decongestants. For over 50 years, they have been assumed to be indirectly acting sympathomimetic amines, their responses ..
- [Drugs and drug abusers]J Schlatter
Service Pharmacie Toxicologie, Centre Hospitalier Universitaire Jean Verdier, Avenue du 14 Juillet, F 93140 Bondy
Presse Med 30:282-7. 2001..Clinical signs of addiction and weaning are observed. OTHERS: Several other drug classes are used by abusers, including analgics, beta-adrenergic agents, nasal vasoconstrictors and corticosteroids...
- Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazolineBritta Haenisch
University of Bonn, Institute of Pharmacology and Toxicology, D 53113 Bonn, Germany
Fundam Clin Pharmacol 24:729-39. 2010..e. at receptors highly expressed at the mRNA level in human nasal mucosa, could eventually explain why in nasal decongestants oxymetazoline can be used in lower concentrations than xylometazoline.
- Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contentsWillem G E J Schoonen
Department of Pharmacology, N V Organon, Molenstraat 110, 5340 BH Oss, The Netherlands
Toxicol In Vitro 19:491-503. 2005..These compounds were non-narcotic antitussives, nasal decongestants, narcotic analgesics, hypnotics, vasodilators, specific cellular energy blockers, cellular proliferation ..
- The effectiveness of nasal decongestants, oral decongestants and oral decongestant-antihistamines in the treatment of acute otitis media in childrenAhmet Eyibilen
Department of Otolaryngology, Medicine Faculty of Gaziosmanpaşa University, Tokat, Turkey
Kulak Burun Bogaz Ihtis Derg 19:289-93. 2009The aim of this study was to evaluate the effectiveness of nasal decongestants, oral decongestants and oral decongestant-antihistamines in the treatment of acute otitis media and resolution of the middle ear effusion in children.
- [Reversible cerebral vasoconstriction syndrome]Anne Ducros
Centre d Urgences Céphalées, Pôle neurosensoriel tête et cou, APHP, Hopital Lariboisiere, F 75010 Paris, France
Presse Med 39:312-22. 2010..g., cannabis, antidepressants, and nasal decongestants) or occur in the postpartum period...
- The role of the nose in the pathogenesis of obstructive sleep apnoea and snoringM Kohler
Oxford Centre for Respiratory Medicine, Oxford OX3 7LJ, UK
Eur Respir J 30:1208-15. 2007..External nasal dilators were used in five studies, topically applied steroids in one, nasal decongestants in two, and surgical treatment in one study...
- Surgery for severe rhinosinusitisE Bradley Strong
Department of Otolaryngology, University of California, Davis, School of Medicine, 2521 Stockton Boulevard, Suite 7200, Sacramento, CA 95817, USA
Clin Rev Allergy Immunol 25:165-76. 2003..This includes a 4-6 wk course of oral antibiotics, nasal steroids, topical nasal decongestants, and oral prednisone if possible...
- Gonadotropin-releasing hormone analogs: update on new findingsM R Henzl
Syntex Research, Palo Alto, California
Am J Obstet Gynecol 166:757-61. 1992..In one series of studies, the effect of nasal mucosal inflammation and the concomitant use of nasal decongestants on the nasal absorption of nafarelin was evaluated in women with perennial rhinitis...
- The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patientsAnne Ducros
Emergency Headache Centre, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, France
Brain 130:3091-101. 2007..to various vasoactive substances in 37, mainly cannabis, selective serotonin-recapture inhibitors and nasal decongestants. The main pattern of presentation (94% of patients) was multiple thunderclap headaches recurring over a ..
- The role of the nose in the pathogenesis of obstructive sleep apneaMalcolm Kohler
Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
Curr Opin Otolaryngol Head Neck Surg 17:33-7. 2009....
- Rhinitis medicamentosa: electron microscopic changes of human nasal mucosaStephan Knipping
Department of Otorhinolaryngology Head and Neck Surgery, The Martin Luther University Halle Wittenberg, Germany
Otolaryngol Head Neck Surg 136:57-61. 2007..Nasal obstruction is induced by rebound swelling when the decongestive effect has disappeared. The aim of this study was to demonstrate ultrastructural changes in RM...
- Phenylpropanolamine decreases food intake in rats made hyperphagic by various stimuliF A Moya-Huff
Department of Pharmacology, Massachusetts College of Pharmacy, Boston 02115
Pharmacol Biochem Behav 28:71-4. 1987Phenylpropanolamine (PPA, d,l-norephedrine), found in many over-the-counter appetite suppressants and nasal decongestants, induces anorexia by a yet unidentified mechanism...
- Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in childrenIvo Slapak
Pediatric Otorhinolaryngology Clinic, Teaching Hospital Brno, Czech Republic
Arch Otolaryngol Head Neck Surg 134:67-74. 2008..To evaluate the potential of nasal isotonic saline application to prevent reappearance of cold and flu in children during the winter...
- [Rhinosinusitis in childhood]G Caramia
Primario Emerito di Pediatria e Neonatologia Azienda Ospedaliera Materno Infantile G Salesi, Ancona
Pediatr Med Chir 27:42-9. 2005..Some researcers demonstrated the effectiveness of this approach, also preventig otitis. Nasal decongestants and antinflammatories are useful, too...
- Sleep and allergic rhinitisJ Muliol
Rhinology Unit and Smell Clinic, ENT Department, Hospital Clinic, Barcelona, Spain
J Investig Allergol Clin Immunol 18:415-9. 2008..of sleep in allergic rhinitis by using medications (antihistamines, topical nasal corticosteroids, nasal decongestants, antileukotrienes) and, finally, the relationship between the sleep apnea syndrome with allergic rhinitis ..
- Secondhand tobacco smoke exposure and chronic rhinosinusitis: a population-based case-control studyDouglas D Reh
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Sinus Center, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA
Am J Rhinol Allergy 23:562-7. 2009..To address this evidence gap, we evaluated the association of SHS and CRS risk in a community-based case-control study of adult nonsmokers...
- Toxicity of drugs used for treatment of rhinitis: a reminder to the otorhinolaryngologistA P Balbani
Otorhinolaryngology Department, University of Sao Paulo Medical School, Brazil
Am J Rhinol 14:77-82. 2000..05) and a preponderance among males aged 5-9 years and females aged 10-39 years. Accidental intake of medicines accounted for the majority of toxicity cases (57.2%)...
- Chronic rhinosinusitis gives a ninefold increased risk of chronic headache. The Akershus study of chronic headacheK Aaseth
Head and Neck Research Group, HØKH, Research Centre, Akershus University Hospital, Lørenskog
Cephalalgia 30:152-60. 2010..surgery, nasal corticosteroids, discontinuation of overused headache medications and discontinuation of nasal decongestants or unspecified reasons...
- Does inhaling menthol affect nasal patency or cough?Priti Kenia
Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
Pediatr Pulmonol 43:532-7. 2008..There is widespread use of menthol in over-the-counter medications, despite scant information on any beneficial effects. Our aim was to assess the effect of menthol on nasal air flow, perception of nasal patency and cough challenge testing...
- Clinical assessment of nasal decongestion test by VAS in adolescentsGian Luigi Marseglia
Dipartimento di Scienze Pediatriche, Università di Pavia Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Pediatr Allergy Immunol 20:187-91. 2009..In conclusion, the use of VAS appears as clinically relevant, in that it allows, with a fair reliability, to perform the decongestion test in the absence of rhinomanometry...
- Effects on nasal nitric oxide production of 2 mechanisms of vasoconstrictionC Serrano
Allergy Unit, Foundation, Valle del Lili Cali, Colombia
J Investig Allergol Clin Immunol 17:337-40. 2007..It is as yet unclear if this last finding is due to the effects of the drug on the enzyme or on the vessels. Physical exercise also induces nasal vasoconstriction and reduces nasal resistance...
- Allergic rhinitis--current pharmacotherapyJohn H Krouse
Rhinology and Allergy, Department of Otolaryngology, Wayne State University, 540 E Canfield, 5E UHC, Detroit, MI 48201, USA
Otolaryngol Clin North Am 41:347-58, vii. 2008..Through an appreciation of these various physiological mechanisms, the physician can select the treatment option or options that will be most likely to effectively manage symptoms...
- Treating common problems of the nose and throat in pregnancy: what is safe?Petros V Vlastarakos
ENT Department, Hippokrateion General Hospital of Athens, 29 Dardanellion str, Glyfada Athens, 16562 Athens, Greece
Eur Arch Otorhinolaryngol 265:499-508. 2008..Non-selective NSAIDs (until the 32nd week), nasal decongestants (with caution and up to 7 days), intranasal corticosteroids, with budesonide as the treatment of choice, ..
- Effect of nasal spray, positional therapy, and the combination thereof in the asymptomatic snorerH M Braver
University of Florida College of Medicine, Gainesville
Sleep 17:516-21. 1994..There was no significant change in snoring using any of these general measures...
- Treating common ear problems in pregnancy: what is safe?Petros V Vlastarakos
ENT Department, Hippokrateion General Hospital of Athens, 114 Vas Sofias Av, Athens, Greece
Eur Arch Otorhinolaryngol 265:139-45. 2008..Non-selective NSAIDs (until the 32nd week), nasal decongestants (with caution and up to 7 days), intranasal corticosteroids, with budesonide as the treatment of choice, ..
- Home medication cabinets and self-medication: a source of potential health threats?Leen De Bolle
Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Ann Pharmacother 42:572-9. 2008..Data regarding the contents of home medication cabinets (HMCs), the management of leftover medications, and the inclination of patients toward self-initiated treatment using nonprescription drugs are scarce...
- The pathophysiology, clinical impact, and management of nasal congestion in allergic rhinitisRobert A Nathan
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
Clin Ther 30:573-86. 2008..Nasal congestion is a cardinal symptom of allergic rhinitis (AR). It is difficult to treat and is associated with decreased quality of life...
- Overview of the treatment of allergic rhinitis and nonallergic rhinopathyAlexander N Greiner
Allergy and Asthma Medical Group and Research Center, 5776 Ruffin Road, San Diego 92123 Suite B, San Diego, CA 92123, USA
Proc Am Thorac Soc 8:121-31. 2011..Furthermore, treatment algorithms for AR and NAR are presented with a stepped-up, stepped-down scheme to aid the clinician in choosing appropriate therapy...
- Adverse events from cough and cold medications after a market withdrawal of products labeled for infantsNadine Shehab
Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop A 24, Atlanta, GA 30333, USA
Pediatrics 126:1100-7. 2010..The goal of this study was to assess CCM-related adverse events (AEs) among children after the withdrawal...
- Prognostic value of anterior rhinomanometry in diode laser turbinoplastyGerd Fabian Volk
Department of Otorhinolaryngology, Friedrich Schiller Universitat, Lessingstraße 2, D 07743 Jena, Germany
Arch Otolaryngol Head Neck Surg 136:1015-9. 2010..To identify objective criteria predicting the success of diode laser-assisted turbinoplasty...
- Effects of orthopedic rapid maxillary expansion on internal nasal dimensions in children with cleft lip and palate assessed by acoustic rhinometryInge Elly Kiemle Trindade
Bauru School of Dentistry and daggerHospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Sao Paulo, Brazil
J Craniofac Surg 21:306-11. 2010..The findings contribute toward the characterization of nasal deformities determined by the cleft and demonstrate the positive effect RME had on nasal morphophysiology in a significant number of the patients who underwent this procedure...
- Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncopeMarianna Fabi
Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Ospedale S Orsola Malpghi, Via Massarenti 9, Bologna BO, Italy
Cardiol Young 19:633-4. 2009..These medications do not require medical prescriptions, so often parents use them, bypassing paediatricians. We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler...
- Efficacy of targeted medical therapy in chronic rhinosinusitis, and predictors of failureDevyani Lal
Department of Otolaryngology Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
Am J Rhinol Allergy 23:396-400. 2009..quot; The objectives of this study were to determine efficacy of a standardized targeted medical therapy (TMT) regimen in CRS and to analyze factors associated with failure of therapy...
- Parental misinterpretations of over-the-counter pediatric cough and cold medication labelsNicole Lokker
Department of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA
Pediatrics 123:1464-71. 2009..Our goal was to examine caregiver understanding of the age indication of over-the-counter cold medication labels and identify factors, associated with caregiver understanding...
- Self-medication in nursing mothers and its influence on the duration of breastfeedingRoberto G Chaves
Ciências da Saúde Saúde da Criança e do Adolescente, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
J Pediatr (Rio J) 85:129-34. 2009..To investigate the practice of self-medication by nursing mothers, the main drugs used and the influence on the duration of breastfeeding...
- Pediatric fatalities associated with over the counter (nonprescription) cough and cold medicationsRichard C Dart
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO 80204, USA
Ann Emerg Med 53:411-7. 2009..We evaluate the role of these medications in pediatric fatalities and identified factors that contributed to the death...
- Congenital nasal pyriform aperture stenosis: diagnosis and managementMarion Devambez
Department of Otolaryngolog Head and Neck Surgery, University Hospital of Lille, France
Cleft Palate Craniofac J 46:262-7. 2009..To review diagnosis and treatment modalities in congenital nasal pyriform aperture stenosis in a newborn population. Study Design: A 6-year retrospective case series review. Mean follow-up of 21.8 months...
- The effects of inhaled L-methamphetamine on athletic performance while riding a stationary bike: a randomised placebo-controlled trialF Dufka
Addiction Pharmacology Lab, California Pacific Medical Center Research Institute, 3555 Cesar Chavez, San Francisco, CA 94110, USA
Br J Sports Med 43:832-5. 2009..This study tested the effects of inhaled L-methamphetamine delivered from a widely available non-prescription product on athletic performance...
- Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedropsS D Pearson
Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132
Clin Chem 35:636-8. 1989....
- A randomized, controlled trial of nasal phenylephrine in infants hospitalized for bronchiolitisShawn Ralston
Department of Pediatrics, Community Medical Center, Missoula, MT, USA
J Pediatr 153:795-8. 2008..To examine the hypothesis that pharmacologic treatment of nasal obstruction, specifically alpha-adrenergic nose drops, will decrease objective signs of respiratory distress in infants with bronchiolitis...
- The use of drugs by UK recreational divers: prescribed and over-the-counter medicationsMarguerite St Leger Dowse
Diving Diseases Research Centre, Hyperbaric Medical Centre, Plymouth, Devon, United Kingdom
Diving Hyperb Med 41:16-21. 2011..As part of a diversion in a study of illicit drug use in sport divers, secondary data regarding the use of prescribed and over-the-counter medications were gathered...
- Ischemic stroke in a man with naphazoline abuse historyGiorgio Costantino
Medicina Interna II, L. Sacco Hospital, Milan, Italy
Am J Emerg Med 25:983.e1-2. 2007
- [Rhinitis medicamentosa in cytological assessment of the nasal mucosa]Bozena Tarchalska
Pol Merkur Lekarski 19:288-90. 2005..medicamentosa and evaluation of usefulness of exfoliative cytology in diagnostics of underlying reason of nasal decongestants overuse. All patients had a history of six months regular use of popular intranasal alpha-adrenomimetics...
- XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXISLouis Vernacchio; Fiscal Year: 2003..A preliminary estimate of the effect size of xylitol treatment from the pilot RCT will suggest whether the effect if sufficiently large to warrant a large formal RCT to be proposed. ..
- Sleep Intervention During Acute Lung InjurySairam Parthasarathy; Fiscal Year: 2010..We will find the best sleep measurement tool and administer a new medication that improves sleep by soothing inflammation which may, in the future, improve the quality of life of patients. ..
- MDMA Dependence and Discontinuation SyndromeJohn Mendelson; Fiscal Year: 2007..Addiction to MDMA appears to be a serious risk of use; our studies will carefttlly define important clinical features of this emerging disorder. ..
- The Effectiveness of Treatment for Adult PeriodontitisPhilippe Hujoel; Fiscal Year: 2006..This information can help determine in what area of periodontal research definitive clinical trials may offer the greatest contribution. ..
- Interleukin-4 effects on calcium in airway smooth muscleJOHN MADISON; Fiscal Year: 2005..Studies will be done with freshly-dispersed bovine and cultured human airway smooth muscle cells. ..
- Clinical Pharmacology of 3,4-Methylenedioxy AmphetaminesJohn E Mendelson; Fiscal Year: 2010..This experiment will investigate the role of alpha-1 adrenergic receptors in the action of MDMA and will provide preliminary data on the possible use of prazosin in the treatment of acute MDMA toxicity. ..
- Sleep Intervention During Acute Lung InjurySairam Parthasarathy; Fiscal Year: 2009..We will find the best sleep measurement tool and administer a new medication that improves sleep by soothing inflammation which may, in the future, improve the quality of life of patients. ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2007..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- CALCIUM REGULATION IN SINGLE AIRWAY SMOOTH MUSCLE CELLSJOHN MADISON; Fiscal Year: 2000..To address these aims, the principal method is radiometric imaging of [Ca2+]i in single, bovine airway smooth muscle cells loaded with the calcium dye, fura-2. ..
- MECHANISMS OF RHINITIS IN CFSJames Baraniuk; Fiscal Year: 1999..e. nasal provocation) as the means to evaluate future treatments of CFS. ..
- CLINICAL PHARMACOLOGY OF METHAMPHETAMINE STEREOISOMERSJohn Mendelson; Fiscal Year: 2003..Primary outcome measures include drug and metabolite measurements in plasma and urine and subjective and cardiovascular measures, including 2D echocardiography. ..