Genomes and Genes
respiratory system agents
Summary: Drugs used for their effects on the respiratory system.
Publications129 found, 100 shown here
- Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trialJurgen Behr
Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
Respir Res 10:101. 2009..To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set...
- Can all patients with COPD use the correct inhalation flow with all inhalers and does training help?Raid A M Al-Showair
School of Pharmacy, Institute of Pharmaceutical Innovation, University of Bradford, Bradford BD7 1DP, UK
Respir Med 101:2395-401. 2007..Some COPD patients have problems achieving required PIFs through DPIs but training is useful to help some exceed the minimum required rate despite only small improvements. The patients found it easier to slow their PIF through the MDI...
- Economic analysis of the Confronting COPD survey: an overview of resultsE F M Wouters
Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Respir Med 97:S3-14. 2003....
- The burden of COPD in the U.S.A.: results from the Confronting COPD surveyM T Halpern
Exponent Inc, Alexandria, VA 22314, U SA
Respir Med 97:S81-9. 2003..The results of the survey suggest that interventions that improve COPD outcomes by decreasing symptoms and preventing acute exacerbations could substantially decrease the costs associated with this disease...
- The burden of COPD in Canada: results from the Confronting COPD surveyK R Chapman
University of Toronto, Ontario, Canada
Respir Med 97:S23-31. 2003..Early diagnosis and the application of available but underused interventions (e.g. smoking cessation, inhaled drug therapies and pulmonary rehabilitation) could reduce the morbidity and costs of COPD in this country...
- The burden of COPD in Italy: results from the Confronting COPD surveyR Dal Negro
Divisione Pneumologia, Ospedale Orlandi, Bussolengo, Verona, Italy
Respir Med 97:S43-50. 2003....
- The burden of COPD in The Netherlands: results from the Confronting COPD surveyE F M Wouters
Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Respir Med 97:S51-9. 2003..In addition, smoking cessation intervention at the early stages of the disease could help to reduce the high costs associated with severe COPD in this country...
- Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic SocietyB Bradley
Royal Infirmary Edinburgh, Little France Crescent, Edinburgh EH16 4SA, UK
Thorax 63:v1-58. 2008
- Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulationCeline Bergeron
Hôpital Laval 2725, Chemin Sainte Foy, Quebec, QC, Canada
Chest 129:1068-87. 2006..The potential of novel therapeutic agents to reverse or prevent airway remodeling is an exciting avenue and warrants further evaluation...
- The burden of COPD in the U.K.: results from the Confronting COPD surveyM Britton
St Peter s Hospital, Chertsey, U K
Respir Med 97:S71-9. 2003....
- The burden of COPD in Spain: results from the Confronting COPD surveyJ L Izquierdo
Pneumology Department, Hospital General Universitario de Guadalajara, Spain
Respir Med 97:S61-9. 2003..Therefore, introducing interventions to reduce the progression to severe COPD could also reduce the impact of the disease...
- Chronic airflow limitation in developing countries: burden and prioritiesNadia Aït-Khaled
International Union Against Tuberculosis and Lung Diseases, Paris, France
Int J Chron Obstruct Pulmon Dis 2:141-50. 2007....
- Respiratory medicineHilary Pinnock
Department of General Practice and Primary Care, University of Aberdeen
Br J Gen Pract 54:539-47. 2004..In this paper the key recommendations of these guidelines and their implementation in the pragmatic world of general practice are discussed, with specific focus on diagnosis, monitoring, management, self-management and delivery of care...
- Effect of doxapram on cerebral blood flow velocity in preterm infantsC Roll
Klinik und Poliklinik für Kinder und Jugendmedizin, Universitatsklinikum Essen, Essen, Germany
Neuropediatrics 35:126-9. 2004..As an unwanted side effect, reduced cerebral perfusion has been seen in methylxanthine-treated infants while effects of doxapram on the cerebral perfusion have not been studied yet...
- Chronic obstructive pulmonary disease: the clinical management of an acute exacerbationJ R Hurst
Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, UK
Postgrad Med J 80:497-505. 2004..In this review we aim to bring the non-specialist reader up to date with current management principles and the evidence underlying such interventions...
- The airway pathophysiology of COPD: implications for treatmentRoberto Rodriguez-Roisin
Servei de Pneumologia, Institut d lnvestigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic, Universitat de Barcelona, Villaroel, 170, 08036 Barcelona, Spain
COPD 2:253-62. 2005....
- Pharmacoeconomics in COPD: lessons for the futureHelen J Starkie
Public Health and Health Policy, University of Glasgow, Glasgow, UK
Int J Chron Obstruct Pulmon Dis 3:71-88. 2008....
- Managing acute on chronic respiratory failure: a guide to non-invasive ventilationJ J P Goldring
Royal Free and University College Medical School, London NW3 2PF
Br J Hosp Med (Lond) 69:444-9. 2008..It is associated with high mortality rates and so practising the best evidence-based management is vital...
- PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilastVictoria Boswell-Smith
The Sackler Institute of Pulmonary Pharmacology, King s College London School of Biomedical and Health Sciences, King s College London, Guys Campus, UK
Int J Chron Obstruct Pulmon Dis 2:121-9. 2007..This review will discuss the current standing of PDE4 inhibitors like roflumilast as novel treatments for COPD and the potential for developing nonemetic anti-inflammatory drugs...
- High dose caffeine citrate for extubation of preterm infants: a randomised controlled trialP Steer
Department of Neonatology and Centre for Clinical Studies, University of Queensland, Mater Health Services, South Brisbane, Australia
Arch Dis Child Fetal Neonatal Ed 89:F499-503. 2004..To compare two dosing regimens for caffeine citrate in the periextubation period for neonates born at less than 30 weeks gestation in terms of successful extubation and adverse effects...
- Olfactory stimulation prevents apnea in premature newbornsLuc Marlier
Centre National de la Recherche Scientifique, UMR 5170, site of Strasbourg, France
Pediatrics 115:83-8. 2005..The present study examines whether exposure to an odor known to modulate the infant's respiratory rate could reduce the frequency of apneic spells...
- An algorithm for the identification of undiagnosed COPD cases using administrative claims dataDouglas W Mapel
Lovelace Clinic Foundation, Albuquerque, New Mexico 87106 4264, USA
J Manag Care Pharm 12:457-65. 2006..This undiagnosed COPD negatively affects health status, and COPD patients may have increased health care utilization several years before the initial diagnosis of COPD is made...
- Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horsesAndrew M Hoffman
Lung Function Testing Laboratory, Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA, USA
J Vet Intern Med 21:184-92. 2007..Horses with recurrent airway obstruction (heaves) are described as exhibiting "increased abdominal effort," but it is unknown whether this translates to an effective contribution to ventilation...
- ABC of chronic obstructive pulmonary disease. Acute exacerbationsGraeme P Currie
Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
BMJ 333:87-9. 2006
- COPD exacerbations. 4: PreventionS Scott
Division of Infection and Immunity, Clinical Sciences Centre, University Hospital Aintree, Liverpool L9 7AL, UK
Thorax 61:440-7. 2006
- Doxapram shortens recovery following sevoflurane anesthesiaChi Chen Wu
Department of Anesthesiology, Taipei Medical University Hospital, 252 Wu Hsin Street, Taipei, Taiwan 110
Can J Anaesth 53:456-60. 2006..A randomized, double blind controlled trial was undertaken to investigate the effect of doxapram on recovery times and bispectral index following sevoflurane anesthesia...
- Treatment of airway mucus hypersecretionDuncan F Rogers
Section of Airway Disease, National Heart and Lung Institute, Imperial College London, UK
Ann Med 38:116-25. 2006..More information is required on these differences to identify specific therapeutic targets which, in turn, should lead to rational design of anti-hypersecretory drugs for treatment of airway mucus hypersecretion in asthma and COPD...
- The transient receptor potential vanilloid 1: role in airway inflammation and diseasePierangelo Geppetti
Clinical Pharmacology Unit, Department of Critical Care Medicine and Surgery, University of Florence, Italy
Eur J Pharmacol 533:207-14. 2006..TRPV1 antagonists may be useful in the treatment of these diseases...
- Nanomedicine for respiratory diseasesUlrich Pison
Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
Eur J Pharmacol 533:341-50. 2006..Based on the recent progress in nanobiotechnology there is potential for nanoparticles and -systems to become useful tools as therapeutic and diagnostic tools in the near future...
- Physiology of airway mucus secretion and pathophysiology of hypersecretionDuncan F Rogers
Airway Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, United Kingdom, SW3 6LY
Respir Care 52:1134-46; discussion 1146-9. 2007....
- Doxapram and developmental delay at 12 months in children born extremely pretermAne Lando
Department of Neonatology, The Juliane Marie Centre, Copenhagen University Hospital, Copenhagen, Denmark
Acta Paediatr 94:1680-1. 2005..To examine the relation of doxapram to a developmental score achieved by a structured telephone interview in a group of extremely-preterm-born children...
- Nonpharmacological and pharmacological interventions to prevent or reduce airway remodellingE H Walters
Cardio Respiratory Research Group, Menzies Research Institute, University of Tasmania, 43 Collins Street, Hobart 7001, Australia
Eur Respir J 30:574-88. 2007..The areas where it is believed urgent research needs to be focused have also been highlighted...
- Brain hemodynamic effects of doxapram in preterm infantsCarlo Dani
Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy
Biol Neonate 89:69-74. 2006....
- Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigsFadi Xu
Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
J Appl Physiol (1985) 99:1782-8. 2005....
- Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorderJustine M Kent
Department of Psychiatry, Unit 41, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Am J Psychiatry 162:1379-81. 2005..The aim of this study was to examine regional cerebral blood flow changes in response to anxiety/panic provocation in subjects with panic disorder and healthy comparison subjects...
- Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransductionToru Takahashi
First Department of Medicine, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higash, Asahikawa 078 8510, Japan
Respir Physiol Neurobiol 147:1-9. 2005..Neither pinacidil nor levcromakalim affected the stimulatory effect of doxapram. We conclude that doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction...
- [Objective criteria for assessing benefits of therapy in COPD - ATS/ERS guidelines 2007]A Cuvelier
Service de pneumologie et unité de soins intensifs respiratoires, CHU de Rouen et UPRES EA 3830 IFR MP23, Institut hospitalo universitaire de recherche biomédicale, Universite de Rouen, 76031 Rouen Cedex, France
Rev Mal Respir 24:827-9. 2007
- Periextubation caffeine in preterm neonates: a randomized dose response trialP A Steer
Centre for Clinical Studies, University of Queensland, Queensland, Australia
J Paediatr Child Health 39:511-5. 2003..To compare the effectiveness of three dosing regimens of caffeine for preterm infants in the periextubation period...
- Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdalaGregory M Sullivan
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Biol Psychiatry 53:863-70. 2003..Doxapram is a respiratory stimulant that reliably evokes panic attacks in patients with panic disorder. We examined doxapram in four rodent models of anxiety and sought to identify brain regions involved in its behavioral effects...
- A new look at the respiratory stimulant doxapramC Spencer Yost
Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143, USA
CNS Drug Rev 12:236-49. 2006..Although it is unlikely that doxapram will undergo a clinical renaissance based on this new understanding, it represents a significant advance in our knowledge of the control of breathing...
- Doxapram and perception of dyspneaSatoru Ebihara
Chest 121:1380-1. 2002
- The effects of doxapram hydrochloride (dopram-V) on laryngeal function in healthy dogsCarrie Jean Miller
Denver Veterinary Specialists, Wheat Ridge, CO 80033, USA
J Vet Intern Med 16:524-8. 2002..We propose the routine use of doxapram during laryngoscopy to increase intrinsic laryngeal motion and aid in the diagnosis of laryngeal dysfunction...
- Management of an acute exacerbation of copd: are we ignoring the evidence?M K Johnson
Department of Respiratory Medicine, Glasgow Royal Infirmary, UK
Thorax 57:II15-II23. 2002
- Current and future therapies for airway mucus hypersecretionPeter J Barnes
National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
Novartis Found Symp 248:237-49; discussion 249-53, 277-82. 2002..However, the clinical benefits from inhibiting mucus hypersecretion are still not certain, casting some doubts on this therapeutic approach...
- Clinical evaluation of new therapies for treatment of mucus hypersecretion in respiratory diseasesBernd Disse
Department of Therapeutic Area Respiratory Diseases, Boehringer Ingelheim Pharma KG, PO Box 200, 55216 Ingelheim, Germany
Novartis Found Symp 248:254-72; discussion 272-6, 277-82. 2002..Proof for no depression of lung mucociliary clearance is an important safety endpoint...
- Treatment of apnea of prematurityVarsha Bhatt-Mehta
Department of Clinical Sciences, College of Pharmacy, University of Michigan, F5203, 200 East Hospital Drive, Ann Arbor, MI 48109, USA
Paediatr Drugs 5:195-210. 2003..The decision to provide a home apnea monitor should be individualized for each patient, depending on the effectiveness of treatment and clinical response...
- Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled studyD Gorecka
Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
Respiration 70:275-83. 2003..Almitrine bismesylate has been shown to improve gas exchange in the lungs. Our hypothesis was that long-term treatment with almitrine might postpone the prescription of LTOT...
- Doxapram produces a dose-dependent reduction in the shivering threshold in rabbitsKatsumi Okuyama
Department of Anesthesia, University of Yamanashi, Faculty of Medicine, Tamaho, Yamanashi, Japan
Anesth Analg 97:759-62. 2003..50 mg x kg(-1) x h(-1) shivered at 33.7 degrees +/- 0.6 degrees C. All the shivering thresholds significantly (P < 0.001) differed from one another. The magnitude of this inhibition, if similar in humans, would be clinically important...
- Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease--2003Denis E O'Donnell
Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada
Can Respir J 10:11A-65A. 2003..Patients with advanced COPD and respiratory failure require a comprehensive management plan that incorporates structured end-of-life care...
- [Respiratory diseases in infants hospitalized during the 1st 2 years of life for viral lower respiratory tract infections: a one-year follow-up]M Giovannini
Clinica Pediatrica Ospedale San Paolo, Universita degli Studi di Milano, Milano, Italy
Minerva Pediatr 55:149-55. 2003..The aim of this study was to evaluate in an Italian population the natural history of respiratory diseases in children hospitalised for LRTI when they were <2 years...
- Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemiaJ Sans-Torres
S Pneumologia, H de Sabadell Corporació Parc Taulí, UAB, Barcelona, Spain
Respir Med 97:599-605. 2003..We studied the long-term effects of AB in COPD patients with chronic hypoxaemia...
- Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injuryJ C Richard
Service de Réanimation Médicale et Assistance Respiratoire, Lyon 69004, France
J Appl Physiol (1985) 93:2181-91. 2002..001). A ventral redistribution of PBF was also obtained with iNO regardless of the position (P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF...
- TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized ratsJoseph F Cotten
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, GRB 444, 55 Fruit St, Boston, MA 02114, USA
Anesth Analg 116:810-6. 2013..PK-THPP and A1899 are potent and selective TASK-1 and TASK-3 antagonists. I hypothesized PK-THPP and A1899 are, like doxapram, breathing stimulants...
- Doxapram and hypokalaemia in very preterm infantsCéline Fischer
Service de Pediatrie, Centre Hospitalier Universitaire, Dijon, France
Arch Dis Child Fetal Neonatal Ed 98:F416-8. 2013..We observed two preterm infants who developed severe hypokalaemia following doxapram. We therefore wished to review the possible association between doxapram and severe hypokalaemia...
- TRP channels as therapeutic targets in airway disorders: a patent reviewDelia Preti
University of Ferrara, Department of Pharmaceutical Sciences, Via Fossato di Mortara 17 19, 44121, Italy
Expert Opin Ther Pat 22:663-95. 2012..Transient receptor potential (TRP) ion channels are emerging molecular target candidates for the development of novel, disease-modifying drugs addressing airway diseases...
- Bu-Fei Yi-Shen granule combined with acupoint sticking therapy in patients with stable chronic obstructive pulmonary disease: a randomized, double-blind, double-dummy, active-controlled, 4-center studyJian Sheng Li
The Geriatric Department of Henan University of Traditional Chinese Medicine, Jinshui District, Zhengzhou, PR China
J Ethnopharmacol 141:584-91. 2012..Bu-Fei Yi-Shen granule combined with acupoint sticking therapy has been used in the patients with stable chronic obstructive pulmonary disease (COPD) as major traditional interventions for the treatment of the disease...
- Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosisNico Derichs
CFTR Biomarker Centre and Translational CF Research Group Christiane Herzog Cystic Fibrosis Centre, Paediatric Pulmonology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur Respir Rev 22:58-65. 2013..The clinical development of ivacaftor not only represents a breakthrough in CF care but also serves as a noteworthy example of personalised medicine...
- Stratified medicine: drugs meet geneticsIan P Hall
Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham, UK
Eur Respir Rev 22:53-7. 2013..This knowledge can then potentially be used to stratify patient groups within (or even across) disease boundaries and then to target therapy more effectively...
- Rescue corticosteroids in twin pregnancies and short-term neonatal outcomesC Bibbo
Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, NY, USA
BJOG 120:58-63. 2013..To estimate the efficacy of a rescue course of antenatal corticosteroids in twin pregnancies...
- Human sinonasal explant system for testing cytotoxicity of intranasal agentsJae H Lim
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
Int Forum Allergy Rhinol 2:63-8. 2012..In order to facilitate safe drug discovery, we developed a simple and reliable in vitro screening assay using human sinonasal explants to measure the cytotoxic profiles of intranasal agents...
- Deposition of inhaled particles in the lungsAna Fernández Tena
Instituto Nacional de Silicosis, Hospital Universitario Central de Asturias, Facultad de Medicina, Universidad de Oviedo, Espana
Arch Bronconeumol 48:240-6. 2012..The deposition of particles in the small airways gets maximum attention from pharmaceutical companies and is of great interest as it is related with a better control in patients receiving these drugs...
- The impact of personalised therapies on respiratory medicineJ Stuart Elborn
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queens University, Belfast, UK
Eur Respir Rev 22:72-4. 2013..This stratified approach to the development of therapies based on the functional class of the mutations in CF is likely to lead to new drugs or combinations that will correct the basic defect in many patients with CF...
- Solid-state chemistry of ambroxol theophylline-7-acetateAnastasia Foppoli
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milano, 20131 Milano, Italy
J Pharm Sci 96:1139-46. 2007....
- An overview of erdosteine antioxidant activity in experimental researchMaurizio Moretti
Clinica di Malattie dell Apparato Respiratorio, Dipartimento di Oncologia, Ematologia e Patologie Apparato Respiratorio, Universita di Modena e Reggio Emilia, Policlinico, Largo del Pozzo 71, 41100 Modena, Italy
Pharmacol Res 55:249-54. 2007..Recent positive clinical trials in humans seem to fulfill the impressive promises that theory and experimental research have put forward...
- Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochlorideMasafumi Miyata
Department of Pediatrics, School of Medicine, Fujita Health University Toyoake, Aichi, Japan
J Perinat Med 35:330-3. 2007..We conclude that low-dose administration of doxapram hydrochloride did not have any undesirable effects on myocardial depolarization and repolarization...
- Minimizing variability of cascade impaction measurements in inhalers and nebulizersMatthew Bonam
Analytical Development, AstraZeneca Charnwood, Loughborough, Leicestershire, UK
AAPS PharmSciTech 9:404-13. 2008....
- Establishing standardised methods for comparing aqueous droplet inhalersE Berg
AstraZeneca R and D, Analytical Development, Scheelevagen 2, S 221 87 Lund, Sweden
Pharmeur Sci Notes 2006:9-15. 2006....
- Emerging therapies for treatment of acute lung injury and acute respiratory distress syndromeKaren J Bosma
University of Western Ontario, Division of Respirology, London Health Sciences Centre, University Hospital, 339 Windermere Road, London, Ontario, N6A 5A5, Canada
Expert Opin Emerg Drugs 12:461-77. 2007....
- Low-tidal-volume ventilationLaurent Chiche
N Engl J Med 357:2518-9; author reply 2519-20. 2007
- Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calvesU Bleul
Clinic of Reproductive Medicine, Department of Food Animals, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
Theriogenology 73:612-9. 2010..Doxapram, but not theophylline, is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects...
- Discontinued drugs, 2007: pulmonary-allergy, dermatological, gastrointestinal and arthritis drugsSabina A Antoniu
Gr T Popa University of Medicine and Pharmacy Iasi, Pulmonary Disease University Hospital, Division of Pulmonary Disease, Iasi, Romania asi ro
Expert Opin Investig Drugs 17:1651-61. 2008..Information for this perspective was derived from a search of the Pharmaprojects database for drugs discontinued after reaching Phase I - III clinical trials...
- Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY programLuca Richeldi
University of Modena and Reggio Emilia, Modena, Italy
Expert Rev Respir Med 5:473-81. 2011..It is likely that pirfenidone will be utilised in many countries as first-line therapy and will also be included in studies of combination therapy for this attritional disease...
- Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouseKrisztian Elekes
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
Eur J Pharmacol 578:313-22. 2008....
- Respiratory drug market dynamicsLisette Oversteegen
Nat Rev Drug Discov 6:695-6. 2007
- Correlates of adherence to respiratory drugs in COPD patientsLaurent Laforest
Unité de Neuro Pharmaco Epidémiologie, CHU University Hospital Lyon, Lyon, France
Prim Care Respir J 19:148-54. 2010..To identify the correlates of accidental omissions and intentional interruptions of respiratory therapy in COPD...
- Development of inhalable dry powder formulation of basic fibroblast growth factorBasma M Ibrahim
Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States
Int J Pharm 385:66-72. 2010..2+/-5.4% and mass median aerodynamic diameter of 4.7+/-0.9 microm) and 98.1+/-7% recovery of bioactive bFGF. This result warrants further investigation of the biological activity of the inhaled bFGF in a disease model...
- Association of obstructive sleep apnea risk with asthma control in adultsMihaela Teodorescu
Medical Service, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
Chest 138:543-50. 2010..Unrecognized obstructive sleep apnea (OSA) may lead to poor asthma control despite optimal therapy. Our objective was to evaluate the relationship between OSA risk and asthma control in adults...
- Drug consumption and air pollution: an overviewFederica Menichini
Faculty of Pharmacy and Nutrition and Health Sciences, Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende, Italy
Pharmacoepidemiol Drug Saf 19:1300-15. 2010..Acute respiratory symptoms are among the health effects of air pollution exposure. Studies over the past decades have linked respiratory drug use (consumption or sales) with changes in air pollution conditions...
- Symptom variability in patients with severe COPD: a pan-European cross-sectional studyR Kessler
Dept of PneumologyNouvel Hôpital Civil, Strasbourg 67000, France
Eur Respir J 37:264-72. 2011..Patient-perceived COPD symptoms vary over the day and the week, and impact on daily activities; morning being the worst time of day. The majority of patients appear not to adjust treatment when symptoms worsen...
- Respiratory and mental health effects of wildfires: an ecological study in Galician municipalities (north-west Spain)Francisco Caamaño-Isorna
Consortium for Biomedical Research in Epidemiology and Public Health, Department of Preventive Medicine, University of Santiago de Compostela, Spain
Environ Health 10:48. 2011..This study sought to analyse the respiratory and mental health effects of the August-2006 fires, using consumption of anxiolytics-hypnotics and drugs for obstructive airway diseases as indicators...
- FDA: cold medications risky for young childrenBridget M Kuehn
JAMA 298:1151. 2007
- [Obesity and hypoventilation syndrome; effects of weight loss and treatment with respiratory stimulants]M Koziej
Kliniki Chorób Płuc, Warszawie
Pneumonol Alergol Pol 64:687-96. 1996..Causes, pathophysiology and possible treatment of obesity-hypoventilation syndrome are discussed...
- Treatment of hypoxemia during one-lung ventilation using intravenous almitrineNicolas Dalibon
Department of Anesthesiology, Hopital Foch, Universite Paris Ouest, Suresnes, France
Anesth Analg 98:590-4, table of contents. 2004..01). Heart rate, arterial blood pressure, and cardiac index did not change throughout the study, but we could obtain an adequate aortic blood flow signal in only half of the patients. Almitrine could be used to treat hypoxemia during OLV...
- Long-term progestin therapy for female chronic respiratory insufficiency?Tarja Saaresranta
Department of Pulmonary Diseases, Turku University Central Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
Respir Med 98:194-5. 2004..This case documents successful control of chronic respiratory failure with medroxyprogesterone in a postmenopausal woman during 1-year follow-up...
- [Costs of chronic obstructive pulmonary disease in Spain. Estimation from a population-based study]J F Masa
Sección de Neumología Hospital San Pedro de Alcántara Cáceres España
Arch Bronconeumol 40:72-9. 2004..The aim of the present study was to estimate the direct cost of COPD on the basis of a representative sample of the overall Spanish population between 40 and 69 years of age (from the IBERPOC study)...
- Flowmetric comparison of respiratory inductance plethysmography and pneumotachography in horsesA Hoffman
Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
J Appl Physiol (1985) 91:2767-75. 2001..01) increases in SFE(max) but not in SFE(int). In conclusion, dynamic comparisons between RIP and Pn provide a defensible method for quantifying AO during tidal breathing, without the need for invasive instrumentation...
- pO2 - Do we treat the right thing?D Kohler
Respiration 70:455-6. 2003
- Beneficial effects of a novel anti-hypoxemic agent, TEI-7322, on bleomycin-induced experimental hypoxemia in ratsH Horiuchi
Teijin Institute for Bio Medical Research, Hino, Tokyo, Japan
Eur J Pharmacol 287:27-34. 1995....
- A study of the effect of nasal steroid sprays in perennial allergic rhinitis patients with rhinitis medicamentosaB J Ferguson
University of Pittsburgh School of Medicine, Eye and Ear Institute and the Department of Otolaryngology, Pennsylvania 15213, USA
Otolaryngol Head Neck Surg 125:253-60. 2001..To determine if rebound congestion can be reduced with concomitant nasal steroid spray usage...
- The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indicesC Herholz
Department of Equine Internal Medicine, Faculty of Veterinary Medicine, University of Berne, Switzerland
Vet Res Commun 25:401-12. 2001..Stimulating respiration with Lobelin gave no advantage in the repeatability of the lung function indices or in differentiating between horses with different degrees of COPD...
- Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injuryR Dembinski
Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Germany
Anesthesiology 94:461-7. 2001..This study was performed to investigate a possible additive effect of prostacyclin and almitrine on pulmonary ventilation-perfusion (VA/Q) ratio in ALI compared with inhaled prostacyclin or intravenous almitrine alone...
- Effect of almitrine on upper airway muscle contraction in young and old ratsD Cantillon
Department of Physiology, Royal College of Surgeons in Ireland, St Stephen s Green, 2, Dublin, Ireland
Eur J Pharmacol 412:187-94. 2001..However, almitrine increases resistance to fatigue in both muscles in young but not in old rats...
- Dose-dependent effects of almitrine on hemodynamics and gas exchange in an animal model of acute lung injuryA Sommerer
Abteilung X, Anaesthesiologie und Intensivmedizin, Bundeswehrkrankenhaus Berlin, Germany
Intensive Care Med 26:434-41. 2000..To determine the dose-response relationship of almitrine (Alm) on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury (ALI)...
- Doxapram accentuates white matter injury in neonatal rats following bilateral carotid artery occlusionH Uehara
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
Neurosci Lett 281:191-4. 2000..1.70+/-0.48, P<0.05) and in the subcortical white matter (0.33+/-0. 67 vs. 1.10+/-0.54, P<0.05). These results demonstrated that the use of doxapram under an ischemic condition accentuates white matter damage in neonatal rats...
- Low-dose doxapram for treatment of apnoea following early weaning in very low birthweight infants: a randomized, double-blind studyC Huon
Service de médecine néonatale de Port Royal, Centre Hospitalier Universitaire Cochin Port Royal, Universite Rene Descartes, Paris, France
Acta Paediatr 87:1180-4. 1998..It is therefore suggested that doxapram, even at low doses, should not be used during the first few days of life. Careful monitoring of blood pressure is required if doxapram is used later...
- UK guidelines for the use of inhaled nitric oxide therapy in adult ICUs. American-European Consensus Conference on ALI/ARDSB H Cuthbertson
Anaesthesia and Intensive Care, Institute of Medical Sciences, Medical School, University of Aberdeen, Scotland
Intensive Care Med 23:1212-8. 1997..Our aim was to produce guidelines for the clinical application of inhaled NO in adult intensive care practice, based upon the current level of published information...
- Additive beneficial effects of the prone position, nitric oxide, and almitrine bismesylate on gas exchange and oxygen transport in acute respiratory distress syndromeP Jolliet
Medical ICU Division, University Hospital, Geneva, Switzerland
Crit Care Med 25:786-94. 1997....
- Bilateral recurrent laryngeal neurectomy as a model for the study of idiopathic canine laryngeal paralysisC L Greenfield
Department of Veterinary Clinical Medicine, University of Illinois, College of Veterinary Medicine, Urbana 61802, USA
Can Vet J 38:163-7. 1997..We concluded that bilateral recurrent laryngeal neurectomy resulted in clinical signs and respiratory changes similar to those of idiopathic canine laryngeal paralysis...
- Lung growth induced by prenatal instillation of perfluorocarbon into the fetal rabbit lungOliver J Muensterer
Department of Pediatric Surgery, University of Munich, Dr von Hauner Children s Hospital, Lindwurmstrasse 4, 80337 Munich, Germany
Pediatr Surg Int 20:248-52. 2004..This novel technique may be a less invasive and less noxious treatment strategy for pulmonary hypoplasia associated with diaphragmatic hernia...
- Hayfever--practical management issuesAndrew Ross
Br J Gen Pract 54:412-4. 2004
- Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug deliveryJoachim Heyder
GSF National Research Center for Environment and Health, Institute for Inhalation Biology, D 85758 Neuherberg Munich, Germany
Proc Am Thorac Soc 1:315-20. 2004..Effective targeting of the bronchial region can only be achieved with bolus inhalations. When particles are suspended in a gas heavier than air, targeting the alveolar region can be enhanced...
- Role of PI3 Kinase and MAP Kinase in Memory RetrievalDaniel R Storm; Fiscal Year: 2010..This study may identify drug target sites that can be used to modulate memory retrieval and be useful clinically. For example, drugs that impair memory retrieval may be used in the treatment of phobias. ..
- CA2+ STIMULATED ADENYLYL CYCLASES AND NEUROPLASTICITYDaniel Storm; Fiscal Year: 2007..abstract_text> ..
- REGULATION OF CAMP TRANSIENTS IN NEURONSDaniel Storm; Fiscal Year: 2007..abstract_text> ..
- Ca2+ Stimulation of MAP Kinase and NeuroplasticityDaniel R Storm; Fiscal Year: 2010..This project focuses on molecular mechanisms underlying memory consolidation and persistence. Consequently, this research may identify new drug target sites that can be exploited to enhance long-term and short-term memory. ..
- CALCIUM SENSITIVE ADENYLYL CYCLASES AND NEUROPLASTICITYDaniel Storm; Fiscal Year: 1999....
- REGULATION OF CAMP TRANSIENTS IN NEURONSDaniel Storm; Fiscal Year: 2003..This study should provide fundamental information concerning the role of AC3 and CaM kinase II for generation of cAMP transients in neurons. ..
- CA2+ STIMULATED ADENYLYL CYCLASES AND NEUROPLASTICITYDaniel Storm; Fiscal Year: 2003..This project should provide fundamental insight concerning molecular mechanisms for neuroplasticity and may ultimately contribute to the development of drugs to treat patients who have deficiencies in learning or memory. ..
- Role of Mucin in Lung Homeostasis and PathophysiologyChristopher M Evans; Fiscal Year: 2010..Achievement of these goals will provide insights into novel treatments of obstructive lung diseases. ..
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2000....
- Smoke Induced Airway Injury in COPDJEANINE M D apos ARMIENTO; Fiscal Year: 2010..The identification of transcription factors regulating protease expression in post smoke exposure will provide novel insight into the pathogenesis of COPD. ..
- Smoke Induced Airway Injury in COPDJEANINE D ARMIENTO; Fiscal Year: 2009..The identification of transcription factors regulating protease expression in post smoke exposure will provide novel insight into the pathogenesis of COPD. ..
- Central Mechanisms of Respiratory ArrestFadi Xu; Fiscal Year: 2007....
- ALTERED MATRIX METALLOPROTEINASES IN HEART FAILUREJEANINE D ARMIENTO; Fiscal Year: 2002..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
- DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASECarlos Camargo; Fiscal Year: 2002..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
- Pathophysiology of Mucus Hypersecretion in AsthmaChristopher Evans; Fiscal Year: 2003..The project proposed here utilizes expertise and reagents available in his laboratory applies them to an important problem in asthma. ..
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2003..With these experiments we expect that a more complete understanding of background K+ channels will emerge and their role in mediating the anesthetic state clarified. ..
- POTASSIUM CHANNEL ACTIVATION BY VOLATILE ANESTHETICSCHARLES YOST; Fiscal Year: 2002..Studies will be carried out in cerebellar granule neurons using whole cell ruptured patch and excised patch techniques on neurons in culture and in thin slices. ..
- Prospective Study of Dietary Factors, BMI, and Risk of Asthma in ChildrenCarlos Camargo; Fiscal Year: 2007..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. ..
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2007..An understanding of the basic mechanisms underlying anesthesia has the potential to lead to improved anesthetic drugs or techniques. ..
- Smoke Induced Airway Injury in COPDJEANINE D ARMIENTO; Fiscal Year: 2007..The identification of transcription factors regulating protease expression in post smoke exposure will provide novel insight into the pathogenesis of COPD. ..
- CEREBELLUM--ROLE IN THE CHEMICAL CONTROL OF BREATHINGFadi Xu; Fiscal Year: 2003..Perhaps, more exciting is the emerging concept that the cerebellum may be far more involved in the planning and executing of motor responses, including respiration, than we have heretofore imagined. ..