respiratory system agents

Summary

Summary: Drugs used for their effects on the respiratory system.

Top Publications

  1. ncbi Economic analysis of the Confronting COPD survey: an overview of results
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 97:S3-14. 2003
  2. pmc Chronic airflow limitation in developing countries: burden and priorities
    Nadia Aït-Khaled
    International Union Against Tuberculosis and Lung Diseases, Paris, France
    Int J Chron Obstruct Pulmon Dis 2:141-50. 2007
  3. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
  4. ncbi The burden of COPD in the U.K.: results from the Confronting COPD survey
    M Britton
    St Peter s Hospital, Chertsey, U K
    Respir Med 97:S71-9. 2003
  5. ncbi The burden of COPD in Spain: results from the Confronting COPD survey
    J L Izquierdo
    Pneumology Department, Hospital General Universitario de Guadalajara, Spain
    Respir Med 97:S61-9. 2003
  6. ncbi Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation
    Celine Bergeron
    Hôpital Laval 2725, Chemin Sainte Foy, Quebec, QC, Canada
    Chest 129:1068-87. 2006
  7. ncbi The burden of COPD in Canada: results from the Confronting COPD survey
    K R Chapman
    University of Toronto, Ontario, Canada
    Respir Med 97:S23-31. 2003
  8. doi Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society
    B Bradley
    Royal Infirmary Edinburgh, Little France Crescent, Edinburgh EH16 4SA, UK
    Thorax 63:v1-58. 2008
  9. ncbi The burden of COPD in The Netherlands: results from the Confronting COPD survey
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 97:S51-9. 2003
  10. ncbi The burden of COPD in Italy: results from the Confronting COPD survey
    R Dal Negro
    Divisione Pneumologia, Ospedale Orlandi, Bussolengo, Verona, Italy
    Respir Med 97:S43-50. 2003

Detail Information

Publications167 found, 100 shown here

  1. ncbi Economic analysis of the Confronting COPD survey: an overview of results
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 97:S3-14. 2003
    ....
  2. pmc Chronic airflow limitation in developing countries: burden and priorities
    Nadia Aït-Khaled
    International Union Against Tuberculosis and Lung Diseases, Paris, France
    Int J Chron Obstruct Pulmon Dis 2:141-50. 2007
    ....
  3. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
    ..To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set...
  4. ncbi The burden of COPD in the U.K.: results from the Confronting COPD survey
    M Britton
    St Peter s Hospital, Chertsey, U K
    Respir Med 97:S71-9. 2003
    ....
  5. ncbi The burden of COPD in Spain: results from the Confronting COPD survey
    J L Izquierdo
    Pneumology Department, Hospital General Universitario de Guadalajara, Spain
    Respir Med 97:S61-9. 2003
    ..Therefore, introducing interventions to reduce the progression to severe COPD could also reduce the impact of the disease...
  6. ncbi Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation
    Celine Bergeron
    Hôpital Laval 2725, Chemin Sainte Foy, Quebec, QC, Canada
    Chest 129:1068-87. 2006
    ..The potential of novel therapeutic agents to reverse or prevent airway remodeling is an exciting avenue and warrants further evaluation...
  7. ncbi The burden of COPD in Canada: results from the Confronting COPD survey
    K R Chapman
    University of Toronto, Ontario, Canada
    Respir Med 97:S23-31. 2003
    ..Early diagnosis and the application of available but underused interventions (e.g. smoking cessation, inhaled drug therapies and pulmonary rehabilitation) could reduce the morbidity and costs of COPD in this country...
  8. doi Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society
    B Bradley
    Royal Infirmary Edinburgh, Little France Crescent, Edinburgh EH16 4SA, UK
    Thorax 63:v1-58. 2008
  9. ncbi The burden of COPD in The Netherlands: results from the Confronting COPD survey
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 97:S51-9. 2003
    ..In addition, smoking cessation intervention at the early stages of the disease could help to reduce the high costs associated with severe COPD in this country...
  10. ncbi The burden of COPD in Italy: results from the Confronting COPD survey
    R Dal Negro
    Divisione Pneumologia, Ospedale Orlandi, Bussolengo, Verona, Italy
    Respir Med 97:S43-50. 2003
    ....
  11. ncbi Can all patients with COPD use the correct inhalation flow with all inhalers and does training help?
    Raid A M Al-Showair
    School of Pharmacy, Institute of Pharmaceutical Innovation, University of Bradford, Bradford BD7 1DP, UK
    Respir Med 101:2395-401. 2007
    ..Some COPD patients have problems achieving required PIFs through DPIs but training is useful to help some exceed the minimum required rate despite only small improvements. The patients found it easier to slow their PIF through the MDI...
  12. ncbi The burden of COPD in the U.S.A.: results from the Confronting COPD survey
    M T Halpern
    Exponent Inc, Alexandria, VA 22314, U SA
    Respir Med 97:S81-9. 2003
    ..The results of the survey suggest that interventions that improve COPD outcomes by decreasing symptoms and preventing acute exacerbations could substantially decrease the costs associated with this disease...
  13. ncbi Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala
    Gregory M Sullivan
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 53:863-70. 2003
    ..Doxapram is a respiratory stimulant that reliably evokes panic attacks in patients with panic disorder. We examined doxapram in four rodent models of anxiety and sought to identify brain regions involved in its behavioral effects...
  14. ncbi Physiology of airway mucus secretion and pathophysiology of hypersecretion
    Duncan F Rogers
    Airway Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, United Kingdom, SW3 6LY
    Respir Care 52:1134-46; discussion 1146-9. 2007
    ....
  15. ncbi An algorithm for the identification of undiagnosed COPD cases using administrative claims data
    Douglas W Mapel
    Lovelace Clinic Foundation, Albuquerque, New Mexico 87106 4264, USA
    J Manag Care Pharm 12:457-65. 2006
    ..This undiagnosed COPD negatively affects health status, and COPD patients may have increased health care utilization several years before the initial diagnosis of COPD is made...
  16. ncbi [Respiratory diseases in infants hospitalized during the 1st 2 years of life for viral lower respiratory tract infections: a one-year follow-up]
    M Giovannini
    Clinica Pediatrica Ospedale San Paolo, Universita degli Studi di Milano, Milano, Italy
    Minerva Pediatr 55:149-55. 2003
    ..The aim of this study was to evaluate in an Italian population the natural history of respiratory diseases in children hospitalised for LRTI when they were <2 years...
  17. ncbi Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia
    J Sans-Torres
    S Pneumologia, H de Sabadell Corporació Parc Taulí, UAB, Barcelona, Spain
    Respir Med 97:599-605. 2003
    ..We studied the long-term effects of AB in COPD patients with chronic hypoxaemia...
  18. ncbi Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease--2003
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada
    Can Respir J 10:11A-65A. 2003
    ..Patients with advanced COPD and respiratory failure require a comprehensive management plan that incorporates structured end-of-life care...
  19. pmc ABC of chronic obstructive pulmonary disease. Acute exacerbations
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 333:87-9. 2006
  20. ncbi Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study
    D Gorecka
    Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Respiration 70:275-83. 2003
    ..Almitrine bismesylate has been shown to improve gas exchange in the lungs. Our hypothesis was that long-term treatment with almitrine might postpone the prescription of LTOT...
  21. ncbi Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction
    Toru Takahashi
    First Department of Medicine, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higash, Asahikawa 078 8510, Japan
    Respir Physiol Neurobiol 147:1-9. 2005
    ..Neither pinacidil nor levcromakalim affected the stimulatory effect of doxapram. We conclude that doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction...
  22. ncbi Olfactory stimulation prevents apnea in premature newborns
    Luc Marlier
    Centre National de la Recherche Scientifique, UMR 5170, site of Strasbourg, France
    Pediatrics 115:83-8. 2005
    ..The present study examines whether exposure to an odor known to modulate the infant's respiratory rate could reduce the frequency of apneic spells...
  23. ncbi Brain hemodynamic effects of doxapram in preterm infants
    Carlo Dani
    Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy
    Biol Neonate 89:69-74. 2006
    ....
  24. pmc High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial
    P Steer
    Department of Neonatology and Centre for Clinical Studies, University of Queensland, Mater Health Services, South Brisbane, Australia
    Arch Dis Child Fetal Neonatal Ed 89:F499-503. 2004
    ..To compare two dosing regimens for caffeine citrate in the periextubation period for neonates born at less than 30 weeks gestation in terms of successful extubation and adverse effects...
  25. pmc Chronic obstructive pulmonary disease: the clinical management of an acute exacerbation
    J R Hurst
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, UK
    Postgrad Med J 80:497-505. 2004
    ..In this review we aim to bring the non-specialist reader up to date with current management principles and the evidence underlying such interventions...
  26. ncbi Nanomedicine for respiratory diseases
    Ulrich Pison
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Eur J Pharmacol 533:341-50. 2006
    ..Based on the recent progress in nanobiotechnology there is potential for nanoparticles and -systems to become useful tools as therapeutic and diagnostic tools in the near future...
  27. ncbi Doxapram and developmental delay at 12 months in children born extremely preterm
    Ane Lando
    Department of Neonatology, The Juliane Marie Centre, Copenhagen University Hospital, Copenhagen, Denmark
    Acta Paediatr 94:1680-1. 2005
    ..To examine the relation of doxapram to a developmental score achieved by a structured telephone interview in a group of extremely-preterm-born children...
  28. pmc Respiratory medicine
    Hilary Pinnock
    Department of General Practice and Primary Care, University of Aberdeen
    Br J Gen Pract 54:539-47. 2004
    ..In this paper the key recommendations of these guidelines and their implementation in the pragmatic world of general practice are discussed, with specific focus on diagnosis, monitoring, management, self-management and delivery of care...
  29. ncbi Effect of doxapram on cerebral blood flow velocity in preterm infants
    C Roll
    Klinik und Poliklinik für Kinder und Jugendmedizin, Universitatsklinikum Essen, Essen, Germany
    Neuropediatrics 35:126-9. 2004
    ..As an unwanted side effect, reduced cerebral perfusion has been seen in methylxanthine-treated infants while effects of doxapram on the cerebral perfusion have not been studied yet...
  30. ncbi The transient receptor potential vanilloid 1: role in airway inflammation and disease
    Pierangelo Geppetti
    Clinical Pharmacology Unit, Department of Critical Care Medicine and Surgery, University of Florence, Italy
    Eur J Pharmacol 533:207-14. 2006
    ..TRPV1 antagonists may be useful in the treatment of these diseases...
  31. ncbi Treatment of airway mucus hypersecretion
    Duncan F Rogers
    Section of Airway Disease, National Heart and Lung Institute, Imperial College London, UK
    Ann Med 38:116-25. 2006
    ..More information is required on these differences to identify specific therapeutic targets which, in turn, should lead to rational design of anti-hypersecretory drugs for treatment of airway mucus hypersecretion in asthma and COPD...
  32. ncbi Doxapram shortens recovery following sevoflurane anesthesia
    Chi Chen Wu
    Department of Anesthesiology, Taipei Medical University Hospital, 252 Wu Hsin Street, Taipei, Taiwan 110
    Can J Anaesth 53:456-60. 2006
    ..A randomized, double blind controlled trial was undertaken to investigate the effect of doxapram on recovery times and bispectral index following sevoflurane anesthesia...
  33. ncbi Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs
    Fadi Xu
    Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
    J Appl Physiol (1985) 99:1782-8. 2005
    ....
  34. ncbi Periextubation caffeine in preterm neonates: a randomized dose response trial
    P A Steer
    Centre for Clinical Studies, University of Queensland, Queensland, Australia
    J Paediatr Child Health 39:511-5. 2003
    ..To compare the effectiveness of three dosing regimens of caffeine for preterm infants in the periextubation period...
  35. ncbi Doxapram produces a dose-dependent reduction in the shivering threshold in rabbits
    Katsumi Okuyama
    Department of Anesthesia, University of Yamanashi, Faculty of Medicine, Tamaho, Yamanashi, Japan
    Anesth Analg 97:759-62. 2003
    ..50 mg x kg(-1) x h(-1) shivered at 33.7 degrees +/- 0.6 degrees C. All the shivering thresholds significantly (P < 0.001) differed from one another. The magnitude of this inhibition, if similar in humans, would be clinically important...
  36. ncbi Treatment of apnea of prematurity
    Varsha Bhatt-Mehta
    Department of Clinical Sciences, College of Pharmacy, University of Michigan, F5203, 200 East Hospital Drive, Ann Arbor, MI 48109, USA
    Paediatr Drugs 5:195-210. 2003
    ..The decision to provide a home apnea monitor should be individualized for each patient, depending on the effectiveness of treatment and clinical response...
  37. ncbi Clinical evaluation of new therapies for treatment of mucus hypersecretion in respiratory diseases
    Bernd Disse
    Department of Therapeutic Area Respiratory Diseases, Boehringer Ingelheim Pharma KG, PO Box 200, 55216 Ingelheim, Germany
    Novartis Found Symp 248:254-72; discussion 272-6, 277-82. 2002
    ..Proof for no depression of lung mucociliary clearance is an important safety endpoint...
  38. ncbi Current and future therapies for airway mucus hypersecretion
    Peter J Barnes
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Novartis Found Symp 248:237-49; discussion 249-53, 277-82. 2002
    ..However, the clinical benefits from inhibiting mucus hypersecretion are still not certain, casting some doubts on this therapeutic approach...
  39. pmc Pharmacoeconomics in COPD: lessons for the future
    Helen J Starkie
    Public Health and Health Policy, University of Glasgow, Glasgow, UK
    Int J Chron Obstruct Pulmon Dis 3:71-88. 2008
    ....
  40. pmc PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast
    Victoria Boswell-Smith
    The Sackler Institute of Pulmonary Pharmacology, King s College London School of Biomedical and Health Sciences, King s College London, Guys Campus, UK
    Int J Chron Obstruct Pulmon Dis 2:121-9. 2007
    ..This review will discuss the current standing of PDE4 inhibitors like roflumilast as novel treatments for COPD and the potential for developing nonemetic anti-inflammatory drugs...
  41. ncbi [Objective criteria for assessing benefits of therapy in COPD - ATS/ERS guidelines 2007]
    A Cuvelier
    Service de pneumologie et unité de soins intensifs respiratoires, CHU de Rouen et UPRES EA 3830 IFR MP23, Institut hospitalo universitaire de recherche biomédicale, Universite de Rouen, 76031 Rouen Cedex, France
    Rev Mal Respir 24:827-9. 2007
  42. ncbi Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horses
    Andrew M Hoffman
    Lung Function Testing Laboratory, Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA, USA
    J Vet Intern Med 21:184-92. 2007
    ..Horses with recurrent airway obstruction (heaves) are described as exhibiting "increased abdominal effort," but it is unknown whether this translates to an effective contribution to ventilation...
  43. ncbi A new look at the respiratory stimulant doxapram
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143, USA
    CNS Drug Rev 12:236-49. 2006
    ..Although it is unlikely that doxapram will undergo a clinical renaissance based on this new understanding, it represents a significant advance in our knowledge of the control of breathing...
  44. ncbi The effects of doxapram hydrochloride (dopram-V) on laryngeal function in healthy dogs
    Carrie Jean Miller
    Denver Veterinary Specialists, Wheat Ridge, CO 80033, USA
    J Vet Intern Med 16:524-8. 2002
    ..We propose the routine use of doxapram during laryngoscopy to increase intrinsic laryngeal motion and aid in the diagnosis of laryngeal dysfunction...
  45. ncbi Managing acute on chronic respiratory failure: a guide to non-invasive ventilation
    J J P Goldring
    Royal Free and University College Medical School, London NW3 2PF
    Br J Hosp Med (Lond) 69:444-9. 2008
    ..It is associated with high mortality rates and so practising the best evidence-based management is vital...
  46. ncbi The airway pathophysiology of COPD: implications for treatment
    Roberto Rodriguez-Roisin
    Servei de Pneumologia, Institut d lnvestigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic, Universitat de Barcelona, Villaroel, 170, 08036 Barcelona, Spain
    COPD 2:253-62. 2005
    ....
  47. pmc Management of an acute exacerbation of copd: are we ignoring the evidence?
    M K Johnson
    Department of Respiratory Medicine, Glasgow Royal Infirmary, UK
    Thorax 57:II15-II23. 2002
  48. ncbi Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury
    J C Richard
    Service de Réanimation Médicale et Assistance Respiratoire, Lyon 69004, France
    J Appl Physiol (1985) 93:2181-91. 2002
    ..001). A ventral redistribution of PBF was also obtained with iNO regardless of the position (P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF...
  49. pmc Panax ginseng C.A Meyer root extract for moderate chronic obstructive pulmonary disease (COPD): study protocol for a randomised controlled trial
    Charlie C Xue
    Discipline of Chinese Medicine, School of Health Sciences and Health Innovations Research Institute HIRi, RMIT University, Bundoora, Vic, Australia
    Trials 12:164. 2011
    ..Several controlled clinical trials using ginseng for COPD have shown promising clinical effect, however these studies were generally small and with some potential bias, prompting the need for rigorously designed studies...
  50. pmc The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial
    Hiroyuki Taniguchi
    Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan
    Respir Res 12:93. 2011
    ..Recently, marginal decline in forced VC (FVC) has been reported to be associated with poor outcome in IPF. We sought to evaluate the efficacy of pirfenidone from the aspects of 5% change in VC...
  51. pmc Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease
    Frits M E Franssen
    Program Development Center, CIRO, Center of Expertise for Chronic Organ Failure, Horn, The Netherlands
    Int J Chron Obstruct Pulmon Dis 6:493-501. 2011
    ....
  52. pmc Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes
    Hyo Bum Kwak
    Department of Kinesiology, East Carolina University, Greenville, NC 27834, USA
    Free Radic Biol Med 52:198-207. 2012
    ....
  53. pmc Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?
    James C Bonner
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    Expert Rev Respir Med 5:779-87. 2011
    ..However, functionalization of CNTs to modulate aspect ratio, biodegradability and to remove residual metals could allow for safe design of CNTs for use in drug delivery in certain circumstances...
  54. ncbi Caesarean section delivery and the risk of allergic disorders in childhood
    H Renz-Polster
    Oregon Health and Science University, Portland OR, USA
    Clin Exp Allergy 35:1466-72. 2005
    ..Beneficial intestinal microbes originate from the maternal vaginal tract and thus are more likely to be transferred during vaginal births than during Caesarean sections (C-sections)...
  55. ncbi Effect of sublingual nitrate on respiratory reflexes arising from stimulation of juxta-pulmonary capillary (J) receptors by i.v. lobeline and short duration exercise
    Ashima Anand
    Exertional Breathlessness Studies Laboratory DST, Vallabhbhai Patel Chest Institute, Delhi University, Delhi 110007, India
    Respir Physiol Neurobiol 181:259-66. 2012
    ....
  56. ncbi Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD
    Mika J Mäkelä
    Division of Allergy, Helsinki University Central Hospital, Skin and Allergy Hospital, PO Box 160, Helskinki, HUS 00029, Finland Electronic address
    Respir Med 107:1481-90. 2013
    ..Further development of measures to improve adherence is needed to fully address these issues. ..
  57. ncbi The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury
    Takeshi Yoshida
    Laboratório de Pneumologia LIM09, Faculdade de Medicina da University of São Paulo, Sao Paulo, Brazil
    Crit Care Med 41:536-45. 2013
    ..We investigated the effects of spontaneous breathing in two different severities of lung injury compared with muscle paralysis...
  58. ncbi Effects of tension of the girth strap on respiratory system mechanics in horses at rest and during hyperpnea induced by administration of lobeline hydrochloride
    Andrew M Hoffman
    Department of Clinical Sciences, Massachusetts School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    Am J Vet Res 66:1167-74. 2005
    ..To determine whether tension of the girth strap of a saddle would sufficiently affect rib motion and reduce lung volume to alter pulmonary resistance in horses...
  59. ncbi Upper respiratory symptoms and other health effects among residents living near the World Trade Center site after September 11, 2001
    Shao Lin
    Center for Environmental Health, New York State Department of Health, Troy, NY 12180, USA
    Am J Epidemiol 162:499-507. 2005
    ..Further analyses are needed to examine whether these increases were related to environmental exposures and to monitor long-term health effects...
  60. ncbi Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 48:247-57. 2012
    ..GesEPOC is a new, more individualized approach to COPD treatment according to the clinical characteristics of the patients...
  61. pmc Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review
    Dongmei Wu
    Department of Research, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Respir Res 12:45. 2011
    ..This article reviews the physiological significance of VIP in cardiopulmonary system and the therapeutic potential of VIP-based agents in the treatment of pulmonary diseases...
  62. ncbi Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling
    E H Walters
    Cardio Respiratory Research Group, Menzies Research Institute, University of Tasmania, 43 Collins Street, Hobart 7001, Australia
    Eur Respir J 30:574-88. 2007
    ..The areas where it is believed urgent research needs to be focused have also been highlighted...
  63. ncbi Guidelines for the diagnosis and treatment of acute and subacute rhinosinusitis in children
    S Esposito
    Institute of Pediatrics, University of Milan, Milan, Italy
    J Chemother 20:147-57. 2008
    ..These guidelines are based on the 125 that were considered truly relevant and reflect the most widely shared positions concerning the diagnosis and treatment of acute, subacute and recurrent rhinosinusitis in children...
  64. ncbi Preparing the dental office for medical emergencies
    Harry Dym
    Department of Dentistry and Oral Maxillofacial Surgery, The Brooklyn Hospital Center, 121 Dekalb Avenue, Brooklyn, NY 11201, USA
    Dent Clin North Am 52:605-8, x. 2008
    ..Emergency drugs that should be stocked include aromatic ammonia, aspirin, and nitroglycerine. The dentist should also develop a protocol and policy for his/her staff to follow when a medical emergency arise...
  65. ncbi Approach to a child with lower airway obstruction and bronchiolitis
    Sudhanshu Grover
    Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Indian J Pediatr 78:1396-400. 2011
    ..Humidified oxygen and supportive therapy are the mainstays of treatment. A trial of inhaled epinephrine or parenteral steroids may be considered for non-responders. It is usually associated with good outcome...
  66. ncbi Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome
    Mohammad Obadah Nakawah
    Department of Family Medicine, San Jacinto Methodist Hospital, Baytown, TX, USA
    J Am Board Fam Med 26:470-7. 2013
    ..Although specific interventions vary by disease, the treatment goals of obstructive airway diseases are similar and driven primarily by the need to control symptoms, optimize health status, and prevent exacerbations. ..
  67. ncbi Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract
    Toru Hiyama
    Health Service Center, Hiroshima University, 1 7 1 Kagamiyama, Higashihiroshima 739 8521, Japan
    J Gastroenterol Hepatol 24:537-46. 2009
    ..Prokinetic agents should be a valuable addition to our currently limited pharmacological armamentarium not only for functional bowel disease, but also for diseases external to the GI tract...
  68. ncbi Measuring disease-specific quality of life in obstructive airway disease: validation of a modified version of the airways questionnaire 20
    Hubert Chen
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0924, USA
    Chest 129:1644-52. 2006
    ..The Airways Questionnaire 20 (AQ20) is a concise measure of health-related quality of life (HRQL) in obstructive airway disease; however, its original format may underestimate impairment due to the complete cessation of certain activities...
  69. ncbi Drug use among children under 5 with respiratory illness and/or diarrhoea in a rural district of Vietnam
    Le Thi Hoan
    Faculty of Public Health, Hanoi Medical University, Hanoi, Vietnam
    Pharmacoepidemiol Drug Saf 18:448-53. 2009
    ..To describe the pattern of drug use among the children with respiratory illnesses and/or diarrhoea; and to analyze the association between various socio-economic factors and pattern of drug use...
  70. ncbi Update on new pulmonary therapies
    George Z Retsch-Bogart
    Division of Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7217, USA
    Curr Opin Pulm Med 15:604-10. 2009
    ..This review focuses on the most notable clinical trials of pulmonary therapies reported in the last year...
  71. ncbi [Effect of doxapram on the respiratory rhythmical discharge activity in the brainstem slice of neonatal rats]
    Guo cai Li
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:245-8. 2010
    ..To investigate the effects of doxapram on the respiratory rhythmical discharge activity (RRDA) in the brainstem slices of neonatal rats...
  72. ncbi Controversies in the treatment of chronic rhinosinusitis
    Jose Maria Guilemany
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology Head and Neck Surgery, Hospital Clinic i Universitari de Barcelona, C Villarroel, 170, Barcelona 08036, Catalonia, Spain
    Expert Rev Respir Med 4:463-77. 2010
    ..Endoscopic sinus surgery is only recommended when medical treatment fails. After surgery, medical treatment, including nasal and oral corticosteroids, is recommended...
  73. pmc COPD exacerbations. 4: Prevention
    S Scott
    Division of Infection and Immunity, Clinical Sciences Centre, University Hospital Aintree, Liverpool L9 7AL, UK
    Thorax 61:440-7. 2006
  74. ncbi Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder
    Justine M Kent
    Department of Psychiatry, Unit 41, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 162:1379-81. 2005
    ..The aim of this study was to examine regional cerebral blood flow changes in response to anxiety/panic provocation in subjects with panic disorder and healthy comparison subjects...
  75. ncbi A quantitative analysis of the intranasal delivery of topical nasal drugs to the middle meatus: spray versus drop administration
    J J Homer
    Department of Otolaryngology Head and Neck Surgery, Leeds Teaching Hospitals, Leeds, UK
    J Laryngol Otol 116:10-3. 2002
    ..8). Thus, there is wide variation in the delivery of topical nasal drugs and the perceived superiority of nasal drop administration, in terms of delivery to the middle meatus, may be incorrect...
  76. ncbi The effects of inhaled nitric oxide and its combination with intravenous almitrine on Pao2 during one-lung ventilation in patients undergoing thoracoscopic procedures
    M Moutafis
    département d anesthésie, Centre Medico Chirurgical Foch, Université Paris Quest, Suresnes, France
    Anesth Analg 85:1130-5. 1997
    ..This beneficial effect of NO/almitrine could be attributed to an improvement in ventilation-perfusion relationships...
  77. ncbi Unlicensed and off-label prescription of respiratory drugs to children
    G W 't Jong
    Dept of Paediatrics, Sophia Children s Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Eur Respir J 23:310-3. 2004
    ..These findings underline the importance of research on suitable formulations, dosages and efficacy of respiratory drugs in children...
  78. ncbi Doxapram and perception of dyspnea
    Satoru Ebihara
    Chest 121:1380-1. 2002
  79. ncbi Randomized, controlled, blinded trial of doxapram for extubation of the very low birthweight infant
    K J Barrington
    Children s Health Centre, Perinatal Research Centre, University of Alberta, Edmonton, Canada
    Acta Paediatr 87:191-4. 1998
    ..Increasing successful extubations in this group of infants will require other strategies...
  80. ncbi Intravenous almitrine bismesylate reversibly induces lactic acidosis and hepatic dysfunction in patients with acute lung injury
    A B'chir
    Departement d Anesthesie Reanimation, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, France
    Anesthesiology 89:823-30. 1998
    ..However, recent research has suggested a potentially harmful effect on lactate metabolism and hepatic function...
  81. ncbi Viral respiratory infection therapy: historical perspectives and current trials
    Jack M Gwaltney
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Med 112:33S-41S. 2002
    ..This strategy reduces viral shedding in nasal fluid, provides treatment for the period of maximum symptom burden, and may reduce the frequency and severity of the sinus disease that accompanies colds...
  82. ncbi The hypoxaemia in chronic obstructive pulmonary disease (COPD) and its management
    C Voisin
    Hopital Albert Calmette, Service de Pneumonologie, Lille, France
    Wiad Lek 51:11-4. 1998
    ....
  83. ncbi [Drugs and breastfeeding]
    Jadwiga Prokopczyk
    Zaklad Farmakologii, Instytut Matki i Dziecka, ul Kasprzaka 17a, Warszawa, Poland
    Med Wieku Rozwoj 6:135-44. 2002
    ..This review summarises the current scientific knowledge on compatibility of drugs with breastfeeding, focusing on drugs that are contraindicated and of which use in breastfeeding remains controversial...
  84. ncbi Pulmonary rehabilitation programs in Canada: national survey
    D Brooks
    Department of Physical Therapy, University of Toronto, Toronto, Canada
    Can Respir J 6:55-63. 1999
    ..To characterize pulmonary rehabilitation (PR) programs in terms of their type, size, duration, patient population, content and staffing...
  85. ncbi Risks and benefits of therapies for apnoea in premature infants
    J M Hascoet
    Medecine et Reanimation Neonatales, Maternite Regionale Universitaire, Nancy, France
    Drug Saf 23:363-79. 2000
    ..Monitoring should be maintained for 4 to 5 days to detect any relapse of recurrent and severe apnoeas, which would lead to the resumption of the most recently withdrawn treatment...
  86. ncbi Spirometric variables recorded after lobeline administration in healthy Friesian and Belgian white and blue calves: normal values and effects of somatic growth
    F Bureau
    Laboratory for Functional Investigation, Department of Physiology, University of Liege, Liege, Belgium
    Vet J 157:302-8. 1999
    ..These results could be related to the lower resistance to respiratory disorders in BWB calves < 1 year of age than in Friesian calves < 1 year of age...
  87. pmc Comparison of the acute effects on gas exchange of nasal ventilation and doxapram in exacerbations of chronic obstructive pulmonary disease
    R M Angus
    Department of Respiratory Medicine, Western Infirmary and Gartnavel General Hospital, Glasgow, UK
    Thorax 51:1048-50. 1996
    ..The effects of NIPPV were compared with those of the respiratory stimulant doxapram on gas exchange in patients with COPD and acute ventilatory failure...
  88. ncbi [Intensive care and respiratory sleep disorders]
    J C Glerant
    Service de Pneumologie, Centre Hospitalier Universitaire Sud, Amiens
    Rev Mal Respir 16:1091-104. 1999
    ....
  89. ncbi Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung
    M A Dolovich
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Respir Care 45:597-608. 2000
    ....
  90. ncbi Metered-dose inhalers, dry powder inhalers, and transitions
    J B Fink
    Division of Pulmonary and Critical Care Medicine, Loyola University of Chicago Stritch School of Medicine, and Hines Veterans Hospital, Illinois, USA
    Respir Care 45:623-35. 2000
    ..The initial offerings of the emerging HFA-propelled pMDI technology appear to be resulting in an improved pMDI...
  91. pmc TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats
    Joseph F Cotten
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, GRB 444, 55 Fruit St, Boston, MA 02114, USA
    Anesth Analg 116:810-6. 2013
    ..PK-THPP and A1899 are potent and selective TASK-1 and TASK-3 antagonists. I hypothesized PK-THPP and A1899 are, like doxapram, breathing stimulants...
  92. ncbi Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis
    Nico Derichs
    CFTR Biomarker Centre and Translational CF Research Group Christiane Herzog Cystic Fibrosis Centre, Paediatric Pulmonology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Respir Rev 22:58-65. 2013
    ..The clinical development of ivacaftor not only represents a breakthrough in CF care but also serves as a noteworthy example of personalised medicine...
  93. ncbi Bu-Fei Yi-Shen granule combined with acupoint sticking therapy in patients with stable chronic obstructive pulmonary disease: a randomized, double-blind, double-dummy, active-controlled, 4-center study
    Jian Sheng Li
    The Geriatric Department of Henan University of Traditional Chinese Medicine, Jinshui District, Zhengzhou, PR China
    J Ethnopharmacol 141:584-91. 2012
    ..Bu-Fei Yi-Shen granule combined with acupoint sticking therapy has been used in the patients with stable chronic obstructive pulmonary disease (COPD) as major traditional interventions for the treatment of the disease...
  94. ncbi Doxapram and hypokalaemia in very preterm infants
    Céline Fischer
    Service de Pediatrie, Centre Hospitalier Universitaire, Dijon, France
    Arch Dis Child Fetal Neonatal Ed 98:F416-8. 2013
    ..We observed two preterm infants who developed severe hypokalaemia following doxapram. We therefore wished to review the possible association between doxapram and severe hypokalaemia...
  95. ncbi TRP channels as therapeutic targets in airway disorders: a patent review
    Delia Preti
    University of Ferrara, Department of Pharmaceutical Sciences, Via Fossato di Mortara 17 19, 44121, Italy
    Expert Opin Ther Pat 22:663-95. 2012
    ..Transient receptor potential (TRP) ion channels are emerging molecular target candidates for the development of novel, disease-modifying drugs addressing airway diseases...
  96. ncbi Stratified medicine: drugs meet genetics
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham, UK
    Eur Respir Rev 22:53-7. 2013
    ..This knowledge can then potentially be used to stratify patient groups within (or even across) disease boundaries and then to target therapy more effectively...
  97. ncbi Deposition of inhaled particles in the lungs
    Ana Fernández Tena
    Instituto Nacional de Silicosis, Hospital Universitario Central de Asturias, Facultad de Medicina, Universidad de Oviedo, Espana
    Arch Bronconeumol 48:240-6. 2012
    ..The deposition of particles in the small airways gets maximum attention from pharmaceutical companies and is of great interest as it is related with a better control in patients receiving these drugs...
  98. pmc Human sinonasal explant system for testing cytotoxicity of intranasal agents
    Jae H Lim
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    Int Forum Allergy Rhinol 2:63-8. 2012
    ..In order to facilitate safe drug discovery, we developed a simple and reliable in vitro screening assay using human sinonasal explants to measure the cytotoxic profiles of intranasal agents...
  99. ncbi Rescue corticosteroids in twin pregnancies and short-term neonatal outcomes
    C Bibbo
    Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, NY, USA
    BJOG 120:58-63. 2013
    ..To estimate the efficacy of a rescue course of antenatal corticosteroids in twin pregnancies...
  100. ncbi The impact of personalised therapies on respiratory medicine
    J Stuart Elborn
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queens University, Belfast, UK
    Eur Respir Rev 22:72-4. 2013
    ..This stratified approach to the development of therapies based on the functional class of the mutations in CF is likely to lead to new drugs or combinations that will correct the basic defect in many patients with CF...
  101. ncbi Dose-dependent effects of almitrine on hemodynamics and gas exchange in an animal model of acute lung injury
    A Sommerer
    Abteilung X, Anaesthesiologie und Intensivmedizin, Bundeswehrkrankenhaus Berlin, Germany
    Intensive Care Med 26:434-41. 2000
    ..To determine the dose-response relationship of almitrine (Alm) on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury (ALI)...

Research Grants11

  1. Calcium and cAMP Regulation of the Circadian Clock
    Daniel Storm; Fiscal Year: 2006
    ..This project uses several novel mouse strains developed in this lab, including a CRE/LacZ reporter strain and AC8 mutant mice. ..
  2. Genetic Modifiers of Cystic Fibrosis
    Michael Boyle; Fiscal Year: 2007
    ..Last, we will evaluate three of the strongest current CF candidate modifier genes to determine if the distribution of their functional alleles segregates with severity of lung disease in our CF clinic population. ..
  3. BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETS
    CHARLES YOST; Fiscal Year: 2008
    ..An understanding of the basic mechanisms underlying anesthesia has the potential to lead to improved anesthetic drugs or techniques. ..
  4. Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
    Carlos Camargo; Fiscal Year: 2008
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Central Mechanisms of Respiratory Arrest
    Fadi Xu; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. POTASSIUM CHANNEL ACTIVATION BY VOLATILE ANESTHETICS
    CHARLES YOST; Fiscal Year: 2002
    ..Studies will be carried out in cerebellar granule neurons using whole cell ruptured patch and excised patch techniques on neurons in culture and in thin slices. ..
  7. CEREBELLUM--ROLE IN THE CHEMICAL CONTROL OF BREATHING
    Fadi Xu; Fiscal Year: 2003
    ..Perhaps, more exciting is the emerging concept that the cerebellum may be far more involved in the planning and executing of motor responses, including respiration, than we have heretofore imagined. ..
  8. Pathophysiology of Mucus Hypersecretion in Asthma
    Christopher Evans; Fiscal Year: 2003
    ..The project proposed here utilizes expertise and reagents available in his laboratory applies them to an important problem in asthma. ..
  9. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  10. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
  11. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..