plasma substitutes

Summary

Summary: Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.

Top Publications

  1. ncbi [Volume replacement with hydroxyethyl starch: is there an influence on kidney function?]
    S Suttner
    Klinik für Anästhesie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:71-7. 2004
  2. ncbi Plasma substitutes
    J Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt, Ludwigshafen, Germany
    Minerva Anestesiol 71:741-58. 2005
  3. ncbi Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence
    Frederic Michard
    Medical ICU, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, Universite Paris XI, France
    Chest 121:2000-8. 2002
  4. doi Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation
    Bodin Khwannimit
    Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Eur J Anaesthesiol 29:64-9. 2012
  5. doi Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review
    Christiane S Hartog
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 37:1725-37. 2011
  6. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000
  7. ncbi Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5
    O Langeron
    , , Paris, France
    Anesth Analg 92:855-62. 2001
  8. ncbi In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOT
    C J Konrad
    Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
    Anesth Analg 90:274-9. 2000
  9. ncbi Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery
    H Berkenstadt
    Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Anesth Analg 92:984-9. 2001
  10. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004

Detail Information

Publications215 found, 100 shown here

  1. ncbi [Volume replacement with hydroxyethyl starch: is there an influence on kidney function?]
    S Suttner
    Klinik für Anästhesie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:71-7. 2004
    ..Furthermore, modern -rapidly degradable HES solutions with a low Mw and DS, such as HES 130/0.4, do not increase the risk for renal dysfunction even when used in large amounts perioperatively...
  2. ncbi Plasma substitutes
    J Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt, Ludwigshafen, Germany
    Minerva Anestesiol 71:741-58. 2005
    ..because aside of the natural colloid albumin several non-protein (synthetic) colloids are available as plasma substitutes (e.g. dextrans, gelatins, hydroxyethyl starch [HES] solutions)...
  3. ncbi Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence
    Frederic Michard
    Medical ICU, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, Universite Paris XI, France
    Chest 121:2000-8. 2002
    ..To identify and critically review the published peer-reviewed, English-language studies investigating predictive factors of fluid responsiveness in ICU patients...
  4. doi Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation
    Bodin Khwannimit
    Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Eur J Anaesthesiol 29:64-9. 2012
    ....
  5. doi Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review
    Christiane S Hartog
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 37:1725-37. 2011
    ..Hydroxyethyl starch solutions (HES) are plasma volume expanders which affect hemostasis. Newer HES 130/0.4 is said to be safer. Reevaluation of published evidence is necessary after the recent retraction of studies...
  6. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000
    ..To compare the new hydroxyethyl starch HES 130/0.4 (Voluven) and the standard HES 200/0.5 (pentastarch) regarding effectiveness for plasma volume substitution and safety of large volumes in heart surgery...
  7. ncbi Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5
    O Langeron
    , , Paris, France
    Anesth Analg 92:855-62. 2001
    ....
  8. ncbi In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOT
    C J Konrad
    Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
    Anesth Analg 90:274-9. 2000
    ..000 seems preferable regarding some aspects of clot formation and retraction. RL affected clot formation only minimally, except for the early activation of clotting, which was measured by a shortened activated clotting time...
  9. ncbi Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery
    H Berkenstadt
    Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Anesth Analg 92:984-9. 2001
    ..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
  10. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  11. ncbi Influence of a long-term, high-dose volume therapy with 6% hydroxyethyl starch 130/0.4 or crystalloid solution on hemodynamics, rheology and hemostasis in patients with acute ischemic stroke. Results of a randomized, placebo-controlled, double-blind study
    Ralph Woessner
    Department of Neurology, Westpfalz Klinikum, University City of Kaiserslautern, Kaiserslautern, Germany
    Pathophysiol Haemost Thromb 33:121-6. 2003
    ..4 versus crystalloid solution, with particular regard to systemic and cerebral hemodynamics, rheology and safety...
  12. ncbi Efficacy and safety of 10% HES 130/0.4 versus 10% HES 200/0.5 for plasma volume expansion in cardiac surgery patients
    C Ertmer
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Muenster Muenster, Germany
    Minerva Med 103:111-22. 2012
    ..g., HES 130/0.4, are characterised by improved pharmacological properties. The present study was designed to compare the efficacy and safety of 10% HES 130/0.4 and 10% HES 200/0.5...
  13. ncbi Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass
    Y S Choi
    Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    Minerva Anestesiol 76:584-91. 2010
    ..4 in the priming solution for a non-biocompatible cardiopulmonary bypass (CPB) circuit. The effects of each substance on coagulation, postoperative blood loss and pro-inflammatory activities were examined...
  14. ncbi Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgery
    Daniel A Reuter
    Department of Anesthesiology, Grosshadern University Hospital, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 28:392-8. 2002
    ....
  15. ncbi Intrathoracic blood volume index measured by thermodilution for preload monitoring after cardiac surgery
    Daniel A Reuter
    Department of Anesthesiology, Ludwig Maximiliaus University GroBhadern University Hospital, Munich, Germany
    J Cardiothorac Vasc Anesth 16:191-5. 2002
    ....
  16. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  17. ncbi The use of transesophageal echocardiography for preload assessment in critically ill patients
    C P Tousignant
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronoto, Ontario, Canada
    Anesth Analg 90:351-5. 2000
    ..Few ICU patients and only those with a small EDA responded to volume administration. It was not possible to identify an overall optimal LV EDA below which most patients demonstrate volume-recruitable increases in SV...
  18. ncbi Effects of gelatine and medium molecular weight starch as priming fluid in cardiopulmonary bypass--a randomised controlled trial
    W W Yap
    Department of Cardiothoracic Surgery, Western Infirmary, Glasgow, United Kingdom
    Perfusion 22:57-61. 2007
    ..The significant increase in intraocular pressure measurements in the Gelofusine group compared to the Voluven group support the hypothesis that Voluven maintains the plasma oncotic pressure better and reduces fluid shift...
  19. ncbi Hydroxyethyl starch (HES) [130/0.4], a new HES specification: pharmacokinetics and safety after multiple infusions of 10% solution in healthy volunteers
    Josef Waitzinger
    AAI Deutschland GmbH and Co KG, Neu Ulm, Germany
    Drugs R D 4:149-57. 2003
    ..To investigate the pharmacokinetics and safety of a daily infusion of 500 mL of hydroxyethyl starch (HES) [130/0.4] 10% solution on 10 consecutive days...
  20. doi Hydroxyethyl starch for cardiovascular surgery: a systematic review of randomized controlled trials
    Xue Yin Shi
    Department of Anaesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, People s Republic of China
    Eur J Clin Pharmacol 67:767-82. 2011
    ..The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions...
  21. ncbi Review article: albumin in the treatment of liver diseases--new features of a classical treatment
    V Arroyo
    Liver Unit, Institute of Digestive Diseases, Hospital Clinic, University of Barcelona, Spain
    Aliment Pharmacol Ther 16:1-5. 2002
    ..Based on this capacity an albumin dialysis system (MARS) has recently been developed. The usefulness of this system in the management of patients with acute and chronic liver failure is, at present, under evaluation...
  22. doi Changes in acid-base, electrolyte and hemoglobin concentrations during infusion of hydroxyethyl starch 130/0.42/6 : 1 in normal saline or in balanced electrolyte solution in children
    Robert Sumpelmann
    Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin OE 8050, Hanover, Germany
    Paediatr Anaesth 20:100-4. 2010
    ..42/6 : 1 in normal saline (ns-HES) and in balanced electrolyte solution (bal-HES) was evaluated in children with a focus on acid-base, electrolyte and hemoglobin changes...
  23. pmc Hydroxyethyl starch versus Ringer solution in cardiopulmonary bypass prime solutions (a randomized controlled trial)
    Osman Tiryakioglu
    Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey
    J Cardiothorac Surg 3:45. 2008
    ..4 solution, which can be a potential alternative prime solution with an indispensable material for the cardio-pulmonary bypass applications...
  24. ncbi Differential storage of hydroxyethyl starch (HES) in the skin: an immunoelectron-microscopical long-term study
    S Ständer
    Department of Dermatology, University of Munster, Germany
    Cell Tissue Res 304:261-9. 2001
    ..The condensation and final dissolution of the vacuoles may either indicate the release and subsequent redistribution of HES into the circulation or lysosomal degradation...
  25. ncbi Bioequivalence comparison between hydroxyethyl starch 130/0.42/6 : 1 and hydroxyethyl starch 130/0.4/9 : 1
    G Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Rhoen Hospital Bad Berka, Kapellendorf, Germany
    Drugs R D 8:229-40. 2007
    ..42/6 : 1), altered in molar substitution and C2/C6 ratio, is bioequivalent to the former standard HES preparation (130/0.4/9 : 1)...
  26. ncbi Tissue storage of 14C-labelled hydroxyethyl starch (HES) 130/0.4 and HES 200/0.5 after repeated intravenous administration to rats
    Jost Leuschner
    LPT Laboratory of Pharmacology and Toxicology, Hamburg, Germany
    Drugs R D 4:331-8. 2003
    ..To investigate the effect of the molar substitution of hydroxyethyl starch (HES) solutions on tissue and organ storage in rats after repeated administration...
  27. ncbi Do plasma substitutes have additional properties beyond correcting volume deficits?
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstrasse 79, D 67063 Ludwigshafen, Germany
    Shock 25:103-16. 2006
    ..There is increasing evidence that some plasma substitutes possess additional effects on organ perfusion, microcirculation, tissue oxygenation, inflammation, ..
  28. ncbi Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion
    M Guevara
    Liver Unit, Hospital Clinic i Provincial, University of Barcelona, Catalunya, Spain
    Hepatology 27:35-41. 1998
    ....
  29. pmc Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study
    Tim Philipp Simon
    Department of Intensive Care and Intermediate Care, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 16:R16. 2012
    ..The type of solution to be used as a fluid replacement remains under discussion. The aim of the study was to evaluate the effects of clinically used fluid replacement solutions on renal function and inflammatory response...
  30. doi Profound effects of cardiopulmonary bypass priming solutions on the fibrin part of clot formation: an ex vivo evaluation using rotation thromboelastometry
    Arinda C M Brinkman
    Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiothorac Vasc Anesth 24:422-6. 2010
    ..Therefore, the authors investigated whether hemodilution with different priming solutions distinctly affects the fibrinogen-mediated step in whole blood clot formation...
  31. ncbi The effects of hydroxyethyl starches of varying molecular weights on platelet function
    A Franz
    Department of Anesthesiology and Intensive Care B, University of Vienna, School of Medicine, Vienna, Austria
    Anesth Analg 92:1402-7. 2001
    ..Our data indicate that fluid resuscitation with HES 130/0.38--0.45 may reduce the risk of bleeding associated with synthetic colloids of higher molecular weight and degree of substitution...
  32. ncbi Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury
    Thomas A Neff
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Anesth Analg 96:1453-9, table of contents. 2003
    ..4 group despite the large HES doses administered. We conclude that HES 130/0.4 can safely be used in critically ill head trauma patients over several days at doses of up to 70 mL x kg(-1) x d(-1)...
  33. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003
    ..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
  34. ncbi Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery
    Joanne Verheij
    Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Intensive Care Med 32:1030-8. 2006
    ..To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery...
  35. ncbi Effects of different plasma substitutes on blood coagulation: a comparative review
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    Crit Care Med 29:1261-7. 2001
    To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss.
  36. doi Modern rapidly degradable hydroxyethyl starches: current concepts
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    Anesth Analg 108:1574-82. 2009
    ..Modern HES preparations are dissolved in balanced, plasma-adapted solutions that no longer contain unphysiological amounts of sodium and chloride and are thus suitable for correcting hypovolemia...
  37. ncbi Coagulation disorders caused by hydroxyethyl starch
    J Treib
    Dept of Neurology, University of the Saarland, Homburg, Germany
    Thromb Haemost 78:974-83. 1997
    ..In Europe, medium-MW HES 200 that is easily degraded and low-MW HES 70 are preferred. In the future, HES should be characterized by the in vivo, not the in vitro MW...
  38. ncbi Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 97:460-70. 2002
    ....
  39. ncbi Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1163-71. 2005
    ..Investigation to determine if clinical enhancement of FXIII activity and/or FI concentration (e.g. fresh-frozen plasma, cryoprecipitate) can attenuate colloid-mediated decreases in hemostasis is warranted...
  40. ncbi Plasma substitution effects of a new hydroxyethyl starch HES 130/0.4 compared with HES 200/0.5 during and after extended acute normovolaemic haemodilution
    B E Ickx
    Department of Anaesthesiology, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Anaesth 91:196-202. 2003
    ..4, was compared with the commonly used HES 200/0.5 after rapid infusion of a single large dose (up to 2 litres) administered during acute normovolaemic haemodilution (ANH)...
  41. ncbi Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses
    Stefan Mario Kasper
    Department of Anesthesiology, University of Cologne, Germany
    Anesthesiology 99:42-7. 2003
    ..4 at a dose of up to 50 ml/kg does not increase blood loss and transfusion requirements in elective coronary artery bypass surgery compared with 6% HES 200/0.5 at a dose of up to 33 ml/kg...
  42. ncbi Hydroxyethyl starch 130/0.4 versus modified fluid gelatin for volume expansion in cardiac surgery patients: the effects on perioperative bleeding and transfusion needs
    Philippe J Van der Linden
    Department of Anesthesiology, CHU Brugmann HUDERF, 4 Place Van Gehuchten, B 1020 Brussels, Belgium
    Anesth Analg 101:629-34, table of contents. 2005
    ..In the conditions of the present study, HES 130/0.4 up to 50 mL/kg is a valuable alternative to modified fluid gelatin for plasma volume expansion during and after cardiac surgery...
  43. ncbi The influence of intravascular volume therapy with a new hydroxyethyl starch preparation (6% HES 130/0.4) on coagulation in patients undergoing major abdominal surgery
    G Haisch
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    Anesth Analg 92:565-71. 2001
    ..After moderate doses of hydroxyethyl starch (2430 +/- 310 mL until the morning of the first postoperative day), coagulation monitoring, including modified thrombelastography, did not show impaired hemostasis...
  44. ncbi HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly
    G B Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:635-44. 2007
    ..HES 130/0.42 with low molecular weight and a low level of substitution has recently been developed in order to reduce those risks...
  45. ncbi Comparison of the acute hemodynamic effects of hypertonic or colloid infusions immediately after mitral valve repair
    D Sirieix
    Department of Anesthesiology, Broussais Hospital, Paris, France
    Crit Care Med 27:2159-65. 1999
    ..To determine the acute hemodynamic effect of hypertonic saline and/or colloid solutions as volume resuscitation in postoperative mitral valve repair patients...
  46. ncbi Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, 35249 6810, USA
    J Surg Res 132:17-22. 2006
    ..Thus, the purpose of the present study was to determine the effect of in vivo hemodilution with Hextend (6% hydroxyethyl starch, mean molecular weight 450 kDa) on plasma coagulation kinetics...
  47. doi [Study protocol of the VISEP study. Response of the SepNet study group]
    K Reinhart
    Anaesthesist 57:723-8. 2008
    ..However, in our opinion this premature action based on wrong assumptions and containing comments by representatives of pharmaceutical companies does not contribute to a serious, unbiased scientific discourse...
  48. ncbi [The design of the VISEP trial. Critical appraisal]
    R Zander
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz
    Anaesthesist 56:71-7. 2007
    ..Thus, any further advance presentations and interpretations should be shelved in expectation of the authors' publication of all the data, in order to begin further discussions including the flaws in study design listed here...
  49. ncbi [Haemodynamic effects following preoperative hypervolemic haemodilution with hypertonic hyperoncotic colloid solutions in coronary artery bypass graft surgery]
    G P Molter
    Klinik für Anaesthesie und Operative Intensivmedizin, Klinikum Leverkusen gGmbH, Leverkusen
    Anaesthesist 52:905-18. 2003
    ....
  50. ncbi Effects of hydroxyethyl starch administration on renal function in critically ill patients
    Y Sakr
    Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:216-24. 2007
    ..We investigated the effect of HES administration on renal function in critically ill patients enrolled in a large multicentre observational European study...
  51. ncbi Hetastarch and bleeding complications after coronary artery surgery
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 124:1437-42. 2003
    ..To determine whether intraoperative HES use is associated with an increased risk of postoperative bleeding following coronary artery bypass graft (CABG) surgery...
  52. ncbi Equivalence of hydroxyethyl starch HES 130/0. 4 and HES 200/0. 5 for perioperative volume replacement in major gynaecological surgery
    O Sander
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Jena, Germany
    Acta Anaesthesiol Scand 47:1151-8. 2003
    ..4 solution with a favourable pharmacological profile and a standard 6% HES 200/0.5 solution for maintenance of haemodynamic stability in major gynaecological surgery...
  53. ncbi Fluid resuscitation in severe sepsis and septic shock: albumin, hydroxyethyl starch, gelatin or ringer's lactate-does it really make a difference?
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 27:520-6. 2007
    ..v. fluid did not affect outcome...
  54. ncbi Hydroxyethyl starch and change in renal function in patients undergoing coronary artery bypass graft surgery
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 64:1046-9. 2003
    ..We sought to study the question in a formal analysis of postoperative change in renal function in patients undergoing coronary artery bypass graft (CABG) surgery...
  55. pmc Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials
    Matthias Jacob
    Klinik fur Anasthesiologie, Ludwig Maximilians Universitat, Klinikum Grosshadern, Nussbaumstrasse 20, D 80336 Munich, Germany
    Crit Care 12:R34. 2008
    ..Small-volume resuscitation can rapidly correct hypovolemia. Hyperoncotic albumin solutions, long in clinical use, are suitable for small-volume resuscitation; however, their clinical benefits remain uncertain...
  56. ncbi Plasma expansion by polyethylene-glycol-modified albumin
    Ragheb A Assaly
    Department of Medicine, Medical College of Ohio, 3120 Glendale Ave, Toledo 43614, USA
    Clin Sci (Lond) 107:263-72. 2004
    ..Based on these data, PEG-Alb appears to be retained within blood vessels in models of capillary leak. PEG-Alb may ultimately be effective in the clinical treatment of shock associated with capillary leak...
  57. ncbi Changes in serum albumin concentration and volume expanding effects following a bolus of albumin 20% in septic patients
    M P Margarson
    Imperial College School of Science, Technology and Medicine, Magill Department of Anaesthesia, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Br J Anaesth 92:821-6. 2004
    ..We assessed volume expansion by albumin 20% infusion and compared the retention of infused albumin in septic patients and healthy controls...
  58. doi The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials
    Sibylle A Kozek-Langenecker
    Department of Special Anesthesiology and Pain Management, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Anesth Analg 107:382-90. 2008
    ..To test this hypothesis, we analyzed pooled data from all available studies in major surgery comparing 6% HES 130/0.4 and 6% HES 200/0.5 from waxy maize starch...
  59. ncbi A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMDM and IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 42:627-34. 2005
    ..This effect is due not only to volume expansion but also to an action on the peripheral arterial circulation...
  60. ncbi Effect of fluid loading with saline or colloids on pulmonary permeability, oedema and lung injury score after cardiac and major vascular surgery
    J Verheij
    Department of Intensive Care, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Br J Anaesth 96:21-30. 2006
    ..The optimal type of fluid for treating hypovolaemia without evoking pulmonary oedema is still unclear, particularly in the presence of pulmonary vascular injury, as may occur after cardiac and major vascular surgery...
  61. ncbi Molar substitution and C2/C6 ratio of hydroxyethyl starch: influence on blood coagulation
    I von Roten
    Department of Anaesthesiology, University Hospital Lausanne, Lausanne, Switzerland
    Br J Anaesth 96:455-63. 2006
    ..In the present study we assessed the individual effects on blood coagulation of molar substitution and C2/C6 ratio of a high molecular weight HES...
  62. ncbi High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 38:229-37. 2001
    ..In this condition increasing plasma viscosity is beneficial and extends the transfusion trigger reducing the use of blood transfusions...
  63. ncbi An alternative method for Plasmodium culture synchronization
    J Lelievre
    Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse, France
    Exp Parasitol 109:195-7. 2005
    ..This method also avoids the use of techniques based on Percoll-glucose gradients. The Plasmion-based technique proved to be a good method and could become an alternative to Plasmagel...
  64. ncbi Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrate
    C Fenger-Eriksen
    Department of Anaesthesiology, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Br J Anaesth 94:324-9. 2005
    b>Plasma substitutes such as hydroxyethyl starch (HES) and various dextrans may compromise the haemostatic system, thereby causing potentially dangerous bleeding...
  65. ncbi Preferred plasma volume expanders for critically ill patients: results of an international survey
    Frederique Schortgen
    Medical and Infectious Diseases Intensive Care Unit, Bichat Claude Bernard Teaching Hospital, 75018 Paris, France
    Intensive Care Med 30:2222-9. 2004
    ..Criteria for plasma volume expander selection in critically ill patients remain controversial. This study evaluated preferences of intensivists regarding plasma volume expanders...
  66. ncbi Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock
    Gernot Marx
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    Crit Care Med 34:3005-10. 2006
    ..Recently, a new HES with a low molecular weight (130 kD) and lower molar substitution (0.42) has been developed. In this study, we compared effects of HES 130/0.42 and HES 200/0.5 on capillary leakage in porcine septic shock...
  67. ncbi Selection of optimal quantity of hydroxyethyl starch in the cardiopulmonary bypass prime
    Maha A Ali
    Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt
    Perfusion 19:41-5. 2004
    ..We concluded that the optimal HES quantity in the prime is two thirds, which insures an 85% reduction of ISF relative to Group II, shorter ventilation and recovery times and avoidance of the hazards of high levels of HES...
  68. ncbi Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin
    Reto Wettstein
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412 USA
    Shock 22:351-7. 2004
    ..7 cP (vs. 2.5 cP for MalPEG-Hb). The present results show that both solutions are efficacious plasma expanders and that the hemoglobin-based solution provides improved oxygen distribution and tissue Po2 in the hamster chamber model...
  69. ncbi Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteers
    Nicholas J Wilkes
    Centre for Anaesthesia, Royal Free and University College London School of Medicine, London, UK
    Anesth Analg 94:538-44; table of contents. 2002
    ..Some hemostatic indices showed moderate changes, and serum amylase demonstrated a temporary increase. Our study suggested that Hextend has pharmacokinetic and pharmacodynamic profiles that are similar to those of other HES...
  70. ncbi Effects of hypertonic saline (7.5%) on extracellular fluid volumes compared with normal saline (0.9%) and 6% hydroxyethyl starch after aortocoronary bypass graft surgery
    K Järvelä
    Department of Anaesthesia, Tampere University Hospital, Tampere, Finland
    J Cardiothorac Vasc Anesth 15:210-5. 2001
    ..To compare the effects of hypertonic (7.5%) saline (HS), normal (0.9%) saline (NS), and 6% hydroxyethyl starch (HES) on extracellular fluid volumes in the early postoperative period after cardiopulmonary bypass...
  71. ncbi Hydroxyethyl starch-induced renal insufficiency after plasma exchange in a patient with polymyositis and liver cirrhosis
    S Peron
    Department of Internal Medicine, Hĵpital Avicenne and Assistance Publique Hĵpitaux de Paris, France
    Clin Nephrol 55:408-11. 2001
    ..Renal insufficiency occurred with biopsy-proven osmotic nephrosis-like lesions, considered to be secondary to HES infusions and/or CyA...
  72. ncbi The influence of crystalloid and colloid replacement solutions in acute normovolemic hemodilution: a preliminary survey of hemostatic markers
    Stephanie B Jones
    Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 75390 9068, USA
    Anesth Analg 96:363-8, table of contents. 2003
    ..The changes in factor VIII, activated partial thromboplastin time, and TEG measurements indicate that HES and DEX may attenuate the hypercoagulability related to surgery...
  73. pmc Advances in fluid resuscitation of hemorrhagic shock
    L N Tremblay
    Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ont
    Can J Surg 44:172-9. 2001
    ..The future role of blood substitutes is not yet defined, but the potential advantages in trauma or elective surgery may prove to be enormous...
  74. ncbi Effects of profound hemodilution on small-intestinal wound healing in rabbits
    R Mandai
    Intensive Care Unit, Shiga University of Medical Science, Shiga, 520 2192, Japan
    J Surg Res 99:107-13. 2001
    ..Wound healing is influenced by tissue oxygen tension and blood perfusion, but not by moderate anemia or hemodilution. The effect of perioperative profound hemodilution on small-intestinal wound healing remains unclear...
  75. ncbi Influence of a new hydroxyethylstarch preparation (HES 130/0.4) on coagulation in cardiac surgical patients
    G Haisch
    Department of Anesthesiology and Intensive Care Medicine, and Clinic of Cardiac Surgery, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    J Cardiothorac Vasc Anesth 15:316-21. 2001
    ..HES 130/0.4 is an alternative plasma substitute to treat volume deficits...
  76. ncbi [Changes in blood volume during acute normovolemic hemodilution with 5% albumin or 6% hydroxyethylstarch and intraoperative retransfusion]
    M Rehm
    Klinik fur Anasthesiologie, Ludwig Maximilians Universitat, Klinikum Grosshadern, Munchen
    Anaesthesist 50:569-79. 2001
    ..What is the impact of acute preoperative normovolemic hemodilution (ANH) on blood volume, intravascular colloid, and loss of red cells in the perioperative period?..
  77. ncbi A randomized, blinded trial comparing the hemostatic effects of pentastarch versus hetastarch
    Ronald G Strauss
    University of Iowa DeGowin Blood Center and the Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Transfusion 42:27-36. 2002
    ..Solutions of HES are widely accepted internationally but are used only modestly in the United States, largely because of concerns over hemostasis...
  78. ncbi The pharmacokinetics and tolerability of an intravenous infusion of the new hydroxyethyl starch 130/0.4 (6%, 500 mL) in mild-to-severe renal impairment
    Cornelius Jungheinrich
    Clinical Research, Fresenius Kabi, 61346 Bad Homburg, Germany
    Anesth Analg 95:544-51, table of contents. 2002
    ..6 mg/mL). We conclude that HES 130/0.4 (500 mL 6%) can be safely administered to patients even with severe renal impairment, as long as urine flow is preserved, without plasma accumulation...
  79. ncbi Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy
    M Rehm
    , , Klinikum Grosshadern, Munich, Germany
    Anesthesiology 95:849-56. 2001
    ..Different, i.e., earlier or later, measuring points, different infusion volumes, infusion rates, plasma substitutes, or possibly different tracers for plasma volume measurement might lead to different results concerning the ..
  80. ncbi Hypertonic saline (7.5%) decreases perioperative weight gain following cardiac surgery
    Kati Järvelä
    Department of Anaesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland
    J Cardiothorac Vasc Anesth 16:43-6. 2002
    ..To compare the effects of 7.5% hypertonic saline (HS) and 0.9% normal saline (NS) on perioperative weight gain in cardiac surgical patients...
  81. ncbi Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study
    F Schortgen
    Medical Intensive-Care Unit, Henri Mondor Hospital, Assistance Publique-H pitaux de Paris, University Paris 12, , France
    Lancet 357:911-6. 2001
    ..57 [1.13-5.83], p=0.026). INTERPRETATIONS: The use of this preparation of hydroxyethylstarch as a plasma-volume expander is an independent risk factor for ARF in patients with severe sepsis or septic shock...
  82. ncbi Effect of intravenous fluids on blood pressure course during hemodialysis in hypotensive-prone patients
    F M van der Sande
    Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    J Am Soc Nephrol 11:550-5. 2000
    ..It is concluded that HES is an effective fluid in maintaining SBP and preserving BV in hypotensive-prone dialysis patients, comparable to albumin but superior to hypertonic saline...
  83. ncbi Effect of intravenous saline, albumin, or hydroxyethylstarch on blood volume during combined ultrafiltration and hemodialysis
    F M van der Sande
    Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    J Am Soc Nephrol 10:1303-8. 1999
    ..It is concluded that HES is a promising fluid in preserving blood volume, comparable to albumin, but superior to saline...
  84. ncbi Distribution of normal saline and 5% albumin infusions in septic patients
    D Ernest
    Intensive Care Unit, St Paul s Hospital and University of British Columbia, Vancouver, Canada
    Crit Care Med 27:46-50. 1999
    ..CONCLUSION: Expansion of the ECFV in excess of the volume of 5% albumin infused suggests that fluid may move from the intracellular fluid volume to the ECFV in septic patients who receive this fluid...
  85. ncbi Resuscitation in shock associated with burns. Tradition or evidence-based medicine?
    C Holm
    Department of Plastic and Reconstructive Surgery Burn Unit, Klinikum Bogenhausen, Technical University Munich, Englschalkingerstrasse 77, 81925, Munich, Germany
    Resuscitation 44:157-64. 2000
    ..To summarize the present standards and guidelines for fluid treatment of shock associated with burns, and to evaluate their scientific support in the literature...
  86. ncbi An international view of hydroxyethyl starches
    J Treib
    Department of Neurology, University Hospital of the Saarland, Homburg, Germany
    Intensive Care Med 25:258-68. 1999
    Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes. A variety of different HES solutions exist worldwide, which differ greatly in their pharmacological properties...
  87. ncbi Small volume hypertonic hydroxyethyl starch reduces acute microvascular dysfunction after closed soft-tissue trauma
    T Mittlmeier
    Humboldt University, Berlin, Germany
    J Bone Joint Surg Br 85:126-32. 2003
    ..It appears to be an effective intervention, supporting nutritional blood flow by reducing trauma-induced microvascular dysfunction...
  88. ncbi Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke
    S Schwarz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1550-5. 1998
    ..The purpose of this study was to prospectively evaluate a protocol with hypertonic saline hydroxyethyl starch (HS-HES) and mannitol in stroke patients with increased intracranial pressure (ICP)...
  89. ncbi Cardiopulmonary effects of 7.2% saline solution compared with gelatin infusion in the early postoperative period after coronary artery bypass grafting
    R Mazhar
    Department of Cardio Thoracic Surgery, Harefield Hospital, Middlesex, London, United Kingdom
    J Thorac Cardiovasc Surg 115:178-89. 1998
    ..We report a clinical study on the use of 7.2%, 2400 mOsm/L, hypertonic saline solution compared with gelatin in early postoperative period after coronary artery bypass surgery...
  90. ncbi Crystalloids, colloids and kids: a review of paediatric burns in intensive care
    A J Cocks
    Emergency Department, The Royal Alexandra Hospital for Children, Parramatta, NSW 2124, Australia
    Burns 24:717-24. 1998
    ..This study is unable to recommend a definitive approach to the fluid resuscitation of burns shock in paediatrics and the best approach is one of meticulous fluid resuscitation titrated on clinical effect...
  91. ncbi Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
    Amy G Tsai
    Dept of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1730-9. 2005
    ..Results support the concept that in extreme hemodilution HV plasma maintains functional capillary density through a NO-mediated vasodilatation...
  92. ncbi The effects of hydroxyethyl starch solution in critically ill patients
    D Palumbo
    Department of Surgical, Anesthesiological Intensive Care and Emergency Sciences, Federico II University of Naples, Naples, Italy
    Minerva Anestesiol 72:655-64. 2006
    ..In this study we have evaluated the effects of volume replacement, carried out with 2 different solutions: hydroxyethyl starch 6% (HAES) and albumin 20% (HA)...
  93. ncbi Comparison between intermittent and continuous measurement of cardiac output after acute normovolemic hemodilution in pigs
    Denise A Otsuki
    Department of Anesthesia LIMOS, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Artif Organs 30:458-66. 2006
    ..New studies are needed to further investigate the agreement between the continuous and intermittent methods for the measurement of CO in adverse hemodynamic conditions such as ANH...
  94. ncbi Renal impact of fluid management with colloids: a comparative review
    I J Davidson
    The University of Texas Southwestern Medical Center at Dallas, Division of Surgical Transplantation, Dallas, Texas 75390, USA
    Eur J Anaesthesiol 23:721-38. 2006
    ..Colloids such as hydroxyethyl starch (HES), gelatin, dextran and albumin are useful for maintaining renal perfusion and function. The comparative renal effects of colloids have not been previously reviewed...
  95. ncbi Which hemostatic changes determine clinical outcome?
    Sibylle Kozek-Langenecker
    Anesth Analg 106:1588; author reply 1588-9. 2008
  96. ncbi Effects of resuscitation with hydroxyethyl starch (HES) on pulmonary hemodynamics and lung lymph balance in hemorrhagic sheep; comparative study of low and high molecular HES
    Toshimichi Kaneki
    First Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi Matsumoto, Shinshu, 390 8621, Japan
    Resuscitation 52:101-8. 2002
    ..These data suggest that low molecular HES is as useful a plasma substitute as high molecular HES, but has a possibility to increase lung lymph filtration during the early phase of resuscitation...
  97. ncbi Hextend attenuates hypercoagulability after severe liver injury in swine
    S Rob Todd
    Department of Surgery, The University of Texas Health Science Center at Houston, Texas 77030, USA
    J Trauma 59:589-93; discussion 593-4. 2005
    ..A resuscitation regimen that modulates this coagulopathy may prove beneficial. We sought to evaluate the effects of lactated Ringer's (LR) solution and Hextend on the resuscitation of uncontrolled hemorrhagic shock...
  98. ncbi Continuous fluid resuscitation and splenectomy for treatment of uncontrolled hemorrhagic shock after massive splenic injury
    Ossama Abu-Hatoum
    Department of General Surgery, Rambam Medical Center, Haifa, Israel
    J Trauma 52:253-8. 2002
    ..Using a standardized massive splenic injury (MSI) model of uncontrolled hemorrhagic shock, we studied the effect of continuous fluid resuscitation and splenectomy on the hemodynamic response and survival in rats...
  99. ncbi Influence of hemorrhagic shock and subsequent fluid resuscitation on the electroencephalographic effect of isoflurane in a swine model
    Tadayoshi Kurita
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Anesthesiology 103:1189-94. 2005
    ..Here, they have investigated the influence of decompensated hemorrhagic shock and subsequent fluid resuscitation on the electroencephalographic effect of isoflurane...
  100. ncbi Evidence for myocardial defects under extreme acute normovolemic hemodilution with hydroxyethyl starch and lactated ringer's solution
    Adilson de Oliveira Fraga
    Department of Anesthesia, Heart Institute Incor Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
    Shock 24:388-95. 2005
    ..Minor loss of cellular integrity with HES, in the presence of very low levels of hemoglobin, reinforces these findings...

Research Grants45

  1. Effects of Glycosylation on RBC Ca2+ Pump in Diabetes
    ROBERT BOOKCHIN; Fiscal Year: 2006
    ....
  2. Patient-Oriented Cancer Research Training Program
    Emil Freireich; Fiscal Year: 2004
    ..The program will prepare oncology physician specialists for careers in academic patient-oriented research in oncology. ..
  3. Bioengineering Methods to Study Blood Substitutes
    Anthony Cheung; Fiscal Year: 2004
    ..abstract_text> ..
  4. SICKLING MECHANISMS AND RED CELL MEMBRANES
    ROBERT BOOKCHIN; Fiscal Year: 2002
    ..Once characterized, these will serve investigations within the above three aims. ..
  5. Enhanced cardiac sympathetic afferent reflex in CHF
    Wei Wang; Fiscal Year: 2004
    ....
  6. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  7. Modulation of Acetylation in the Treatment of Lethal Hemorrhagic Shock
    Hasan B Alam; Fiscal Year: 2010
    ..The aim of our project is to refine this novel approach, and develop effective strategies for the treatment of lethal blood loss. ..
  8. Post-Injury Dysregulation of Lipid Metabolism
    GREGORY VICTORINO; Fiscal Year: 2007
    ..I will also receive guidance from Dr Twomey, Emeritus Professor and expert in medical editing and biostatistics, which will help me improve my ability to communicate with other scientists. ..
  9. San Franisco Injury Center for Research and Prevention
    M Knudson; Fiscal Year: 2007
    ....
  10. Transfusion Medicine/Hemostasis Clinical Research Network
    Ronald Strauss; Fiscal Year: 2007
    ..Many millions more have problems with thrombocytopenia, neutropenia and anemia. This network has established a building block for future research to help treat and combat these problems. UNIVERSITY OF IOWA CRITIQUES ..
  11. Transfusion Medicine/Hemostasis Clinical Trials Network
    Mark Brecher; Fiscal Year: 2007
    ..Two TMH CTN protocols are ongoing at UNC, and it is the intention of the investigators at this site to support new network protocols in the future. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CRITIQUES ..
  12. STUDIES OF SICKLING MECHANISMS & RED CELL MEMBRANES
    ROBERT BOOKCHIN; Fiscal Year: 1993
    ....
  13. STUDIES OF SICKLING MECHANISMS AND RED CELL MEMBRANES
    ROBERT BOOKCHIN; Fiscal Year: 1990
    ....