plasma substitutes

Summary

Summary: Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.

Top Publications

  1. ncbi [Volume replacement with hydroxyethyl starch: is there an influence on kidney function?]
    S Suttner
    Klinik für Anästhesie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:71-7. 2004
  2. ncbi Plasma substitutes
    J Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt, Ludwigshafen, Germany
    Minerva Anestesiol 71:741-58. 2005
  3. ncbi Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence
    Frederic Michard
    Medical ICU, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, Universite Paris XI, France
    Chest 121:2000-8. 2002
  4. ncbi Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass
    Y S Choi
    Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    Minerva Anestesiol 76:584-91. 2010
  5. ncbi Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    Alexey A Schramko
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 108:30-6. 2009
  6. ncbi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
  7. ncbi Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)
    M F M James
    Department of Anaesthesia, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, Western Cape 7925, South Africa
    Br J Anaesth 107:693-702. 2011
  8. ncbi Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation
    Bodin Khwannimit
    Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Eur J Anaesthesiol 29:64-9. 2012
  9. ncbi Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review
    Christiane S Hartog
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 37:1725-37. 2011
  10. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000

Research Grants

Detail Information

Publications234 found, 100 shown here

  1. ncbi [Volume replacement with hydroxyethyl starch: is there an influence on kidney function?]
    S Suttner
    Klinik für Anästhesie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:71-7. 2004
    ..Furthermore, modern -rapidly degradable HES solutions with a low Mw and DS, such as HES 130/0.4, do not increase the risk for renal dysfunction even when used in large amounts perioperatively...
  2. ncbi Plasma substitutes
    J Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt, Ludwigshafen, Germany
    Minerva Anestesiol 71:741-58. 2005
    ..because aside of the natural colloid albumin several non-protein (synthetic) colloids are available as plasma substitutes (e.g. dextrans, gelatins, hydroxyethyl starch [HES] solutions)...
  3. ncbi Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence
    Frederic Michard
    Medical ICU, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, Universite Paris XI, France
    Chest 121:2000-8. 2002
    ..To identify and critically review the published peer-reviewed, English-language studies investigating predictive factors of fluid responsiveness in ICU patients...
  4. ncbi Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass
    Y S Choi
    Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    Minerva Anestesiol 76:584-91. 2010
    ..4 in the priming solution for a non-biocompatible cardiopulmonary bypass (CPB) circuit. The effects of each substance on coagulation, postoperative blood loss and pro-inflammatory activities were examined...
  5. ncbi Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    Alexey A Schramko
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 108:30-6. 2009
    ..Because the risk of bleeding is increased after cardiopulmonary bypass, we examined whether these types of HES solutions could be administered after cardiac surgery without an alteration of coagulation...
  6. ncbi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    ..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
  7. ncbi Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)
    M F M James
    Department of Anaesthesia, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, Western Cape 7925, South Africa
    Br J Anaesth 107:693-702. 2011
    ..We compared resuscitation with 0.9% saline vs hydroxyethyl starch, HES 130/0.4, in severe trauma with respect to resuscitation, fluid volume, gastrointestinal recovery, renal function, and blood product requirements...
  8. ncbi Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation
    Bodin Khwannimit
    Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Eur J Anaesthesiol 29:64-9. 2012
    ....
  9. ncbi Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review
    Christiane S Hartog
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 37:1725-37. 2011
    ..Hydroxyethyl starch solutions (HES) are plasma volume expanders which affect hemostasis. Newer HES 130/0.4 is said to be safer. Reevaluation of published evidence is necessary after the recent retraction of studies...
  10. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000
    ..To compare the new hydroxyethyl starch HES 130/0.4 (Voluven) and the standard HES 200/0.5 (pentastarch) regarding effectiveness for plasma volume substitution and safety of large volumes in heart surgery...
  11. ncbi Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy
    M Rehm
    , , Klinikum Grosshadern, Munich, Germany
    Anesthesiology 95:849-56. 2001
    ..Different, i.e., earlier or later, measuring points, different infusion volumes, infusion rates, plasma substitutes, or possibly different tracers for plasma volume measurement might lead to different results concerning the ..
  12. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003
    ..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
  13. pmc Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
    Ronald J Trof
    Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
    Intensive Care Med 36:697-701. 2010
    ..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
  14. ncbi Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    A Schramko
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki HUS, Finland
    Br J Anaesth 104:691-7. 2010
    ..Both hydroxyethylstarch (HES) and gelatin solutions impair haemostasis. We examined the impact and dose effect on coagulation of HES 130/0.4, gelatin, or Ringer's acetate solutions after cardiac surgery...
  15. pmc Operating room use of hypertonic solutions: a clinical review
    Gustavo Azoubel
    Department of Surgery, University of Toronto, Toronto, Canada
    Clinics (Sao Paulo) 63:833-40. 2008
    ..Examining the immunomodulatory effects of hypertonic solutions should also be a priority in future studies...
  16. ncbi Safety of modern starches used during surgery
    Philippe Van der Linden
    Service d Anesthésiologie Réanimation, CHU Brugmann, Bruxelles, Belgium
    Anesth Analg 116:35-48. 2013
    ..73 [95% confidence interval = 0.61-0.87], P = 0.0005), or increased mortality (odds ratio for HES mortality = 0.51 [0.24-1.05], P = 0.079)...
  17. ncbi Hemodilution and fluid management in neurosurgery
    Ramachandra P Tummala
    Department of Neurological Surgery, University of Miami School of Medicine, Florida, USA
    Clin Neurosurg 53:238-51. 2006
  18. ncbi Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat
    Maris Dubniks
    Department of Anesthesiology and Intensive Care, Lund University Hospital, 22185, Lund, Sweden
    Intensive Care Med 33:293-9. 2007
    ..4 with one another and with normal saline regarding their plasma expanding effects at increased permeability and to compare the results with those from a previous study at normal permeability...
  19. ncbi Efficacy and safety of 10% HES 130/0.4 versus 10% HES 200/0.5 for plasma volume expansion in cardiac surgery patients
    C Ertmer
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Muenster Muenster, Germany
    Minerva Med 103:111-22. 2012
    ..g., HES 130/0.4, are characterised by improved pharmacological properties. The present study was designed to compare the efficacy and safety of 10% HES 130/0.4 and 10% HES 200/0.5...
  20. ncbi The effects of hydroxyethyl starch solution in critically ill patients
    D Palumbo
    Department of Surgical, Anesthesiological Intensive Care and Emergency Sciences, Federico II University of Naples, Naples, Italy
    Minerva Anestesiol 72:655-64. 2006
    ..In this study we have evaluated the effects of volume replacement, carried out with 2 different solutions: hydroxyethyl starch 6% (HAES) and albumin 20% (HA)...
  21. ncbi Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 97:460-70. 2002
    ....
  22. ncbi Intrathoracic blood volume index measured by thermodilution for preload monitoring after cardiac surgery
    Daniel A Reuter
    Department of Anesthesiology, Ludwig Maximiliaus University GroBhadern University Hospital, Munich, Germany
    J Cardiothorac Vasc Anesth 16:191-5. 2002
    ....
  23. ncbi Kinetics of isotonic and hypertonic plasma volume expanders
    Dan Drobin
    Department of Anesthesiology, Soder Hospital, Stockholm, Sweden
    Anesthesiology 96:1371-80. 2002
    ..Major differences in plasma volume expansion between infusion fluids are fairly well known, but there is a lack of methods that express their dynamic properties. Therefore, a closer description enabled by kinetic modeling is presented...
  24. ncbi Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery
    Joanne Verheij
    Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Intensive Care Med 32:1030-8. 2006
    ..To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery...
  25. ncbi Comparison of the acute hemodynamic effects of hypertonic or colloid infusions immediately after mitral valve repair
    D Sirieix
    Department of Anesthesiology, Broussais Hospital, Paris, France
    Crit Care Med 27:2159-65. 1999
    ..To determine the acute hemodynamic effect of hypertonic saline and/or colloid solutions as volume resuscitation in postoperative mitral valve repair patients...
  26. ncbi In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOT
    C J Konrad
    Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
    Anesth Analg 90:274-9. 2000
    ..000 seems preferable regarding some aspects of clot formation and retraction. RL affected clot formation only minimally, except for the early activation of clotting, which was measured by a shortened activated clotting time...
  27. ncbi The use of transesophageal echocardiography for preload assessment in critically ill patients
    C P Tousignant
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronoto, Ontario, Canada
    Anesth Analg 90:351-5. 2000
    ..Few ICU patients and only those with a small EDA responded to volume administration. It was not possible to identify an overall optimal LV EDA below which most patients demonstrate volume-recruitable increases in SV...
  28. ncbi High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 38:229-37. 2001
    ..In this condition increasing plasma viscosity is beneficial and extends the transfusion trigger reducing the use of blood transfusions...
  29. ncbi Effect of fluid loading with saline or colloids on pulmonary permeability, oedema and lung injury score after cardiac and major vascular surgery
    J Verheij
    Department of Intensive Care, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Br J Anaesth 96:21-30. 2006
    ..The optimal type of fluid for treating hypovolaemia without evoking pulmonary oedema is still unclear, particularly in the presence of pulmonary vascular injury, as may occur after cardiac and major vascular surgery...
  30. ncbi Human neutrophil activation and increased adhesion by various resuscitation fluids
    P Rhee
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Crit Care Med 28:74-8. 2000
    ..We hypothesized that human neutrophil activation and adhesion vary, depending on the type and amount of resuscitation fluid used...
  31. ncbi [Haemodynamic effects following preoperative hypervolemic haemodilution with hypertonic hyperoncotic colloid solutions in coronary artery bypass graft surgery]
    G P Molter
    Klinik für Anaesthesie und Operative Intensivmedizin, Klinikum Leverkusen gGmbH, Leverkusen
    Anaesthesist 52:905-18. 2003
    ....
  32. ncbi Effect of intravenous fluids on blood pressure course during hemodialysis in hypotensive-prone patients
    F M van der Sande
    Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    J Am Soc Nephrol 11:550-5. 2000
    ..It is concluded that HES is an effective fluid in maintaining SBP and preserving BV in hypotensive-prone dialysis patients, comparable to albumin but superior to hypertonic saline...
  33. ncbi Hypertonic saline dextran--the fluid of choice in the resuscitation of haemorrhagic shock?
    W Sapsford
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton, Salisbury Wiltshire, SP4 0JQ
    J R Army Med Corps 149:110-20. 2003
  34. ncbi Influence of a long-term, high-dose volume therapy with 6% hydroxyethyl starch 130/0.4 or crystalloid solution on hemodynamics, rheology and hemostasis in patients with acute ischemic stroke. Results of a randomized, placebo-controlled, double-blind study
    Ralph Woessner
    Department of Neurology, Westpfalz Klinikum, University City of Kaiserslautern, Kaiserslautern, Germany
    Pathophysiol Haemost Thromb 33:121-6. 2003
    ..4 versus crystalloid solution, with particular regard to systemic and cerebral hemodynamics, rheology and safety...
  35. ncbi Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery
    H Berkenstadt
    Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Anesth Analg 92:984-9. 2001
    ..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
  36. ncbi Plasma volume expansion and transcapillary fluid exchange in skeletal muscle of albumin, dextran, gelatin, hydroxyethyl starch, and saline after trauma in the cat
    Johan Persson
    Department of Anesthesiology and Intensive Care, Lund University and Lund University Hospital, Sweden
    Crit Care Med 34:2456-62. 2006
    ..5% gelatin, 6% hydroxyethyl starch 130/0.4, and saline regarding their plasma volume expanding effect after a surgical skeletal muscle trauma and their simultaneous effects on transvascular fluid exchange in skeletal muscle...
  37. ncbi Hydroxyethyl starch for cardiovascular surgery: a systematic review of randomized controlled trials
    Xue Yin Shi
    Department of Anaesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, People s Republic of China
    Eur J Clin Pharmacol 67:767-82. 2011
    ..The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions...
  38. pmc Hydroxyethyl starch versus Ringer solution in cardiopulmonary bypass prime solutions (a randomized controlled trial)
    Osman Tiryakioglu
    Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey
    J Cardiothorac Surg 3:45. 2008
    ..4 solution, which can be a potential alternative prime solution with an indispensable material for the cardio-pulmonary bypass applications...
  39. ncbi Changes in acid-base, electrolyte and hemoglobin concentrations during infusion of hydroxyethyl starch 130/0.42/6 : 1 in normal saline or in balanced electrolyte solution in children
    Robert Sumpelmann
    Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin OE 8050, Hanover, Germany
    Paediatr Anaesth 20:100-4. 2010
    ..42/6 : 1 in normal saline (ns-HES) and in balanced electrolyte solution (bal-HES) was evaluated in children with a focus on acid-base, electrolyte and hemoglobin changes...
  40. ncbi Hydroxyethyl starch (HES) [130/0.4], a new HES specification: pharmacokinetics and safety after multiple infusions of 10% solution in healthy volunteers
    Josef Waitzinger
    AAI Deutschland GmbH and Co KG, Neu Ulm, Germany
    Drugs R D 4:149-57. 2003
    ..To investigate the pharmacokinetics and safety of a daily infusion of 500 mL of hydroxyethyl starch (HES) [130/0.4] 10% solution on 10 consecutive days...
  41. ncbi Effects of gelatine and medium molecular weight starch as priming fluid in cardiopulmonary bypass--a randomised controlled trial
    W W Yap
    Department of Cardiothoracic Surgery, Western Infirmary, Glasgow, United Kingdom
    Perfusion 22:57-61. 2007
    ..The significant increase in intraocular pressure measurements in the Gelofusine group compared to the Voluven group support the hypothesis that Voluven maintains the plasma oncotic pressure better and reduces fluid shift...
  42. ncbi Review article: albumin in the treatment of liver diseases--new features of a classical treatment
    V Arroyo
    Liver Unit, Institute of Digestive Diseases, Hospital Clinic, University of Barcelona, Spain
    Aliment Pharmacol Ther 16:1-5. 2002
    ..Based on this capacity an albumin dialysis system (MARS) has recently been developed. The usefulness of this system in the management of patients with acute and chronic liver failure is, at present, under evaluation...
  43. ncbi Do plasma substitutes have additional properties beyond correcting volume deficits?
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstrasse 79, D 67063 Ludwigshafen, Germany
    Shock 25:103-16. 2006
    ..There is increasing evidence that some plasma substitutes possess additional effects on organ perfusion, microcirculation, tissue oxygenation, inflammation, ..
  44. ncbi Bioequivalence comparison between hydroxyethyl starch 130/0.42/6 : 1 and hydroxyethyl starch 130/0.4/9 : 1
    G Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Rhoen Hospital Bad Berka, Kapellendorf, Germany
    Drugs R D 8:229-40. 2007
    ..42/6 : 1), altered in molar substitution and C2/C6 ratio, is bioequivalent to the former standard HES preparation (130/0.4/9 : 1)...
  45. ncbi Tissue storage of 14C-labelled hydroxyethyl starch (HES) 130/0.4 and HES 200/0.5 after repeated intravenous administration to rats
    Jost Leuschner
    LPT Laboratory of Pharmacology and Toxicology, Hamburg, Germany
    Drugs R D 4:331-8. 2003
    ..To investigate the effect of the molar substitution of hydroxyethyl starch (HES) solutions on tissue and organ storage in rats after repeated administration...
  46. ncbi Differential storage of hydroxyethyl starch (HES) in the skin: an immunoelectron-microscopical long-term study
    S Ständer
    Department of Dermatology, University of Munster, Germany
    Cell Tissue Res 304:261-9. 2001
    ..The condensation and final dissolution of the vacuoles may either indicate the release and subsequent redistribution of HES into the circulation or lysosomal degradation...
  47. ncbi Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion
    M Guevara
    Liver Unit, Hospital Clinic i Provincial, University of Barcelona, Catalunya, Spain
    Hepatology 27:35-41. 1998
    ....
  48. pmc Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study
    Tim Philipp Simon
    Department of Intensive Care and Intermediate Care, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 16:R16. 2012
    ..The type of solution to be used as a fluid replacement remains under discussion. The aim of the study was to evaluate the effects of clinically used fluid replacement solutions on renal function and inflammatory response...
  49. ncbi Profound effects of cardiopulmonary bypass priming solutions on the fibrin part of clot formation: an ex vivo evaluation using rotation thromboelastometry
    Arinda C M Brinkman
    Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiothorac Vasc Anesth 24:422-6. 2010
    ..Therefore, the authors investigated whether hemodilution with different priming solutions distinctly affects the fibrinogen-mediated step in whole blood clot formation...
  50. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  51. ncbi The effects of hydroxyethyl starches of varying molecular weights on platelet function
    A Franz
    Department of Anesthesiology and Intensive Care B, University of Vienna, School of Medicine, Vienna, Austria
    Anesth Analg 92:1402-7. 2001
    ..Our data indicate that fluid resuscitation with HES 130/0.38--0.45 may reduce the risk of bleeding associated with synthetic colloids of higher molecular weight and degree of substitution...
  52. ncbi Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury
    Thomas A Neff
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Anesth Analg 96:1453-9, table of contents. 2003
    ..4 group despite the large HES doses administered. We conclude that HES 130/0.4 can safely be used in critically ill head trauma patients over several days at doses of up to 70 mL x kg(-1) x d(-1)...
  53. ncbi Reversal of diuretic-induced hepatic encephalopathy with infusion of albumin but not colloid
    Rajiv Jalan
    Liver Failure Group, Institute of Hepatology, University College London Medical School, London WC1E 6HX, UK
    Clin Sci (Lond) 106:467-74. 2004
    ..These data support the notion that other factors, such as oxidative stress, act as adjuncts to ammonia in the pathogenesis of diuretic-induced HE and suggest a possible role for albumin infusion in its treatment...
  54. ncbi Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5
    O Langeron
    , , Paris, France
    Anesth Analg 92:855-62. 2001
    ....
  55. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  56. ncbi Hematocrit, volume expander, temperature, and shear rate effects on blood viscosity
    D M Eckmann
    Departments of Anesthesia and Neurology, and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia 19096, USA
    Anesth Analg 91:539-45. 2000
    ..92, p: < 0.001)...
  57. ncbi Effects of hydroxyethyl starch on hepatic production of cytokines and activation of transcription factors in lipopolysaccharide-administered rats
    R Lv
    Nanjing University School of Medicine, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210 002, China
    Acta Anaesthesiol Scand 49:635-42. 2005
    Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes. Some studies have indicated that HES may have anti-inflammatory effects...
  58. ncbi Plasma volume changes associated with two hydroxyethyl starch colloids following acute hypovolaemia in volunteers
    M F M James
    Centre for Anaesthesia, University College London, London, UK
    Anaesthesia 59:738-42. 2004
    ..The large molecular weight starch (Hextend) provided a less well-sustained volume expansion effect than the smaller one (Voluven)..
  59. ncbi The effects of hydroxyethyl starch solutions on thromboelastography in preoperative male patients
    M Felfernig
    Department of Anesthesiology and Intensive Care B, University of Vienna, School of Medicine, Austria
    Acta Anaesthesiol Scand 47:70-3. 2003
    ..A comparison of the in vivo effects of high, middle and low molecular weight HES solutions on TEG variables has not been performed so far...
  60. ncbi Cold-induced fluid extravasation during cardiopulmonary bypass in piglets can be counteracted by use of iso-oncotic prime
    Marit Farstad
    Department of Anesthesia and Intensive Care, University of Bergen, Haukeland University Hospital, Bergen, Norway
    J Thorac Cardiovasc Surg 130:287-94. 2005
    ..This study aimed to compare whether iso-oncotic priming solutions, in contrast to crystalloids, could reduce the cold-induced fluid extravasation during cardiopulmonary bypass in piglets...
  61. ncbi Effects of different plasma substitutes on blood coagulation: a comparative review
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    Crit Care Med 29:1261-7. 2001
    To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss.
  62. ncbi Colloids versus crystalloids and tissue oxygen tension in patients undergoing major abdominal surgery
    K Lang
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, D-67063 Ludwigshafen, Germany
    Anesth Analg 93:405-9 , 3rd contents page. 2001
    ..The ptiO(2) increased in the HES-treated (+59%) but decreased in the RL-treated (-23%) patients. Improved microcirculation may be the mechanism for the better ptiO(2) in the HES group...
  63. ncbi Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgery
    Daniel A Reuter
    Department of Anesthesiology, Grosshadern University Hospital, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 28:392-8. 2002
    ....
  64. ncbi Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1163-71. 2005
    ..Investigation to determine if clinical enhancement of FXIII activity and/or FI concentration (e.g. fresh-frozen plasma, cryoprecipitate) can attenuate colloid-mediated decreases in hemostasis is warranted...
  65. ncbi Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses
    Stefan Mario Kasper
    Department of Anesthesiology, University of Cologne, Germany
    Anesthesiology 99:42-7. 2003
    ..4 at a dose of up to 50 ml/kg does not increase blood loss and transfusion requirements in elective coronary artery bypass surgery compared with 6% HES 200/0.5 at a dose of up to 33 ml/kg...
  66. ncbi Plasma substitution effects of a new hydroxyethyl starch HES 130/0.4 compared with HES 200/0.5 during and after extended acute normovolaemic haemodilution
    B E Ickx
    Department of Anaesthesiology, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Anaesth 91:196-202. 2003
    ..4, was compared with the commonly used HES 200/0.5 after rapid infusion of a single large dose (up to 2 litres) administered during acute normovolaemic haemodilution (ANH)...
  67. ncbi Hydroxyethyl starch 130/0.4 versus modified fluid gelatin for volume expansion in cardiac surgery patients: the effects on perioperative bleeding and transfusion needs
    Philippe J Van der Linden
    Department of Anesthesiology, CHU Brugmann HUDERF, 4 Place Van Gehuchten, B 1020 Brussels, Belgium
    Anesth Analg 101:629-34, table of contents. 2005
    ..In the conditions of the present study, HES 130/0.4 up to 50 mL/kg is a valuable alternative to modified fluid gelatin for plasma volume expansion during and after cardiac surgery...
  68. ncbi HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly
    G B Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:635-44. 2007
    ..HES 130/0.42 with low molecular weight and a low level of substitution has recently been developed in order to reduce those risks...
  69. ncbi Modern rapidly degradable hydroxyethyl starches: current concepts
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    Anesth Analg 108:1574-82. 2009
    ..Modern HES preparations are dissolved in balanced, plasma-adapted solutions that no longer contain unphysiological amounts of sodium and chloride and are thus suitable for correcting hypovolemia...
  70. ncbi The influence of intravascular volume therapy with a new hydroxyethyl starch preparation (6% HES 130/0.4) on coagulation in patients undergoing major abdominal surgery
    G Haisch
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    Anesth Analg 92:565-71. 2001
    ..After moderate doses of hydroxyethyl starch (2430 +/- 310 mL until the morning of the first postoperative day), coagulation monitoring, including modified thrombelastography, did not show impaired hemostasis...
  71. ncbi Coagulation disorders caused by hydroxyethyl starch
    J Treib
    Dept of Neurology, University of the Saarland, Homburg, Germany
    Thromb Haemost 78:974-83. 1997
    ..In Europe, medium-MW HES 200 that is easily degraded and low-MW HES 70 are preferred. In the future, HES should be characterized by the in vivo, not the in vitro MW...
  72. ncbi Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke
    S Schwarz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1550-5. 1998
    ..The purpose of this study was to prospectively evaluate a protocol with hypertonic saline hydroxyethyl starch (HS-HES) and mannitol in stroke patients with increased intracranial pressure (ICP)...
  73. ncbi Crystalloids, colloids and kids: a review of paediatric burns in intensive care
    A J Cocks
    Emergency Department, The Royal Alexandra Hospital for Children, Parramatta, NSW 2124, Australia
    Burns 24:717-24. 1998
    ..This study is unable to recommend a definitive approach to the fluid resuscitation of burns shock in paediatrics and the best approach is one of meticulous fluid resuscitation titrated on clinical effect...
  74. ncbi Selection of optimal quantity of hydroxyethyl starch in the cardiopulmonary bypass prime
    Maha A Ali
    Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt
    Perfusion 19:41-5. 2004
    ..We concluded that the optimal HES quantity in the prime is two thirds, which insures an 85% reduction of ISF relative to Group II, shorter ventilation and recovery times and avoidance of the hazards of high levels of HES...
  75. ncbi Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, 35249 6810, USA
    J Surg Res 132:17-22. 2006
    ..Thus, the purpose of the present study was to determine the effect of in vivo hemodilution with Hextend (6% hydroxyethyl starch, mean molecular weight 450 kDa) on plasma coagulation kinetics...
  76. ncbi Cardiopulmonary effects of 7.2% saline solution compared with gelatin infusion in the early postoperative period after coronary artery bypass grafting
    R Mazhar
    Department of Cardio Thoracic Surgery, Harefield Hospital, Middlesex, London, United Kingdom
    J Thorac Cardiovasc Surg 115:178-89. 1998
    ..We report a clinical study on the use of 7.2%, 2400 mOsm/L, hypertonic saline solution compared with gelatin in early postoperative period after coronary artery bypass surgery...
  77. ncbi Fluid resuscitation in severe sepsis and septic shock: albumin, hydroxyethyl starch, gelatin or ringer's lactate-does it really make a difference?
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 27:520-6. 2007
    ..v. fluid did not affect outcome...
  78. ncbi Plasma expansion by polyethylene-glycol-modified albumin
    Ragheb A Assaly
    Department of Medicine, Medical College of Ohio, 3120 Glendale Ave, Toledo 43614, USA
    Clin Sci (Lond) 107:263-72. 2004
    ..Based on these data, PEG-Alb appears to be retained within blood vessels in models of capillary leak. PEG-Alb may ultimately be effective in the clinical treatment of shock associated with capillary leak...
  79. ncbi Hydroxyethyl starch-induced renal insufficiency after plasma exchange in a patient with polymyositis and liver cirrhosis
    S Peron
    Department of Internal Medicine, Hĵpital Avicenne and Assistance Publique Hĵpitaux de Paris, France
    Clin Nephrol 55:408-11. 2001
    ..Renal insufficiency occurred with biopsy-proven osmotic nephrosis-like lesions, considered to be secondary to HES infusions and/or CyA...
  80. ncbi Effects of hydroxyethyl starch administration on renal function in critically ill patients
    Y Sakr
    Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:216-24. 2007
    ..We investigated the effect of HES administration on renal function in critically ill patients enrolled in a large multicentre observational European study...
  81. ncbi Molar substitution and C2/C6 ratio of hydroxyethyl starch: influence on blood coagulation
    I von Roten
    Department of Anaesthesiology, University Hospital Lausanne, Lausanne, Switzerland
    Br J Anaesth 96:455-63. 2006
    ..In the present study we assessed the individual effects on blood coagulation of molar substitution and C2/C6 ratio of a high molecular weight HES...
  82. ncbi Preferred plasma volume expanders for critically ill patients: results of an international survey
    Frederique Schortgen
    Medical and Infectious Diseases Intensive Care Unit, Bichat Claude Bernard Teaching Hospital, 75018 Paris, France
    Intensive Care Med 30:2222-9. 2004
    ..Criteria for plasma volume expander selection in critically ill patients remain controversial. This study evaluated preferences of intensivists regarding plasma volume expanders...
  83. ncbi Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin
    Reto Wettstein
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412 USA
    Shock 22:351-7. 2004
    ..7 cP (vs. 2.5 cP for MalPEG-Hb). The present results show that both solutions are efficacious plasma expanders and that the hemoglobin-based solution provides improved oxygen distribution and tissue Po2 in the hamster chamber model...
  84. ncbi Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrate
    C Fenger-Eriksen
    Department of Anaesthesiology, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Br J Anaesth 94:324-9. 2005
    b>Plasma substitutes such as hydroxyethyl starch (HES) and various dextrans may compromise the haemostatic system, thereby causing potentially dangerous bleeding...
  85. ncbi A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMDM and IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 42:627-34. 2005
    ..This effect is due not only to volume expansion but also to an action on the peripheral arterial circulation...
  86. ncbi Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock
    Gernot Marx
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    Crit Care Med 34:3005-10. 2006
    ..Recently, a new HES with a low molecular weight (130 kD) and lower molar substitution (0.42) has been developed. In this study, we compared effects of HES 130/0.42 and HES 200/0.5 on capillary leakage in porcine septic shock...
  87. ncbi [The design of the VISEP trial. Critical appraisal]
    R Zander
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz
    Anaesthesist 56:71-7. 2007
    ..Thus, any further advance presentations and interpretations should be shelved in expectation of the authors' publication of all the data, in order to begin further discussions including the flaws in study design listed here...
  88. ncbi An alternative method for Plasmodium culture synchronization
    J Lelievre
    Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse, France
    Exp Parasitol 109:195-7. 2005
    ..This method also avoids the use of techniques based on Percoll-glucose gradients. The Plasmion-based technique proved to be a good method and could become an alternative to Plasmagel...
  89. ncbi Changes in serum albumin concentration and volume expanding effects following a bolus of albumin 20% in septic patients
    M P Margarson
    Imperial College School of Science, Technology and Medicine, Magill Department of Anaesthesia, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Br J Anaesth 92:821-6. 2004
    ..We assessed volume expansion by albumin 20% infusion and compared the retention of infused albumin in septic patients and healthy controls...
  90. ncbi Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteers
    Nicholas J Wilkes
    Centre for Anaesthesia, Royal Free and University College London School of Medicine, London, UK
    Anesth Analg 94:538-44; table of contents. 2002
    ..Some hemostatic indices showed moderate changes, and serum amylase demonstrated a temporary increase. Our study suggested that Hextend has pharmacokinetic and pharmacodynamic profiles that are similar to those of other HES...
  91. doi [Study protocol of the VISEP study. Response of the SepNet study group]
    K Reinhart
    Anaesthesist 57:723-8. 2008
    ..However, in our opinion this premature action based on wrong assumptions and containing comments by representatives of pharmaceutical companies does not contribute to a serious, unbiased scientific discourse...
  92. ncbi Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study
    F Schortgen
    Medical Intensive-Care Unit, Henri Mondor Hospital, Assistance Publique-H pitaux de Paris, University Paris 12, , France
    Lancet 357:911-6. 2001
    ..57 [1.13-5.83], p=0.026). INTERPRETATIONS: The use of this preparation of hydroxyethylstarch as a plasma-volume expander is an independent risk factor for ARF in patients with severe sepsis or septic shock...
  93. ncbi Small volume hypertonic hydroxyethyl starch reduces acute microvascular dysfunction after closed soft-tissue trauma
    T Mittlmeier
    Humboldt University, Berlin, Germany
    J Bone Joint Surg Br 85:126-32. 2003
    ..It appears to be an effective intervention, supporting nutritional blood flow by reducing trauma-induced microvascular dysfunction...
  94. ncbi The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials
    Sibylle A Kozek-Langenecker
    Department of Special Anesthesiology and Pain Management, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Anesth Analg 107:382-90. 2008
    ..To test this hypothesis, we analyzed pooled data from all available studies in major surgery comparing 6% HES 130/0.4 and 6% HES 200/0.5 from waxy maize starch...
  95. ncbi Effects of hypertonic saline (7.5%) on extracellular fluid volumes compared with normal saline (0.9%) and 6% hydroxyethyl starch after aortocoronary bypass graft surgery
    K Järvelä
    Department of Anaesthesia, Tampere University Hospital, Tampere, Finland
    J Cardiothorac Vasc Anesth 15:210-5. 2001
    ..To compare the effects of hypertonic (7.5%) saline (HS), normal (0.9%) saline (NS), and 6% hydroxyethyl starch (HES) on extracellular fluid volumes in the early postoperative period after cardiopulmonary bypass...
  96. ncbi A randomized, blinded trial comparing the hemostatic effects of pentastarch versus hetastarch
    Ronald G Strauss
    University of Iowa DeGowin Blood Center and the Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Transfusion 42:27-36. 2002
    ..Solutions of HES are widely accepted internationally but are used only modestly in the United States, largely because of concerns over hemostasis...
  97. pmc Advances in fluid resuscitation of hemorrhagic shock
    L N Tremblay
    Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ont
    Can J Surg 44:172-9. 2001
    ..The future role of blood substitutes is not yet defined, but the potential advantages in trauma or elective surgery may prove to be enormous...
  98. ncbi The pharmacokinetics and tolerability of an intravenous infusion of the new hydroxyethyl starch 130/0.4 (6%, 500 mL) in mild-to-severe renal impairment
    Cornelius Jungheinrich
    Clinical Research, Fresenius Kabi, 61346 Bad Homburg, Germany
    Anesth Analg 95:544-51, table of contents. 2002
    ..6 mg/mL). We conclude that HES 130/0.4 (500 mL 6%) can be safely administered to patients even with severe renal impairment, as long as urine flow is preserved, without plasma accumulation...
  99. ncbi Effects of profound hemodilution on small-intestinal wound healing in rabbits
    R Mandai
    Intensive Care Unit, Shiga University of Medical Science, Shiga, 520 2192, Japan
    J Surg Res 99:107-13. 2001
    ..Wound healing is influenced by tissue oxygen tension and blood perfusion, but not by moderate anemia or hemodilution. The effect of perioperative profound hemodilution on small-intestinal wound healing remains unclear...
  100. ncbi Influence of a new hydroxyethylstarch preparation (HES 130/0.4) on coagulation in cardiac surgical patients
    G Haisch
    Department of Anesthesiology and Intensive Care Medicine, and Clinic of Cardiac Surgery, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    J Cardiothorac Vasc Anesth 15:316-21. 2001
    ..HES 130/0.4 is an alternative plasma substitute to treat volume deficits...

Research Grants8

  1. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE RUSSELL BURNETT; Fiscal Year: 2013
    ..applicant): Although numerous advances have been made in the treatment of severe hemorrhage, current blood plasma substitutes do not address new insights in resuscitation medicine...
  2. SICKLING MECHANISMS AND RED CELL MEMBRANES
    ROBERT BOOKCHIN; Fiscal Year: 2002
    ..Once characterized, these will serve investigations within the above three aims. ..
  3. Bioengineering Methods to Study Blood Substitutes
    Anthony Cheung; Fiscal Year: 2004
    ..abstract_text> ..
  4. Patient-Oriented Cancer Research Training Program
    Emil Freireich; Fiscal Year: 2004
    ..The program will prepare oncology physician specialists for careers in academic patient-oriented research in oncology. ..
  5. Enhanced cardiac sympathetic afferent reflex in CHF
    Wei Wang; Fiscal Year: 2004
    ....
  6. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  7. Effects of Glycosylation on RBC Ca2+ Pump in Diabetes
    ROBERT BOOKCHIN; Fiscal Year: 2006
    ..unreadable] [unreadable]..