cathartics

Summary

Summary: Agents that promote and/or ease defecation by accelerating the passage of feces through the large intestine, by influencing the consistency and amount of stool, and by facilitating the elimination of feces from the rectum. The terms laxative and cathartic reflect the typical intensity and latency of effect. A cathartic usually produces prompt fluid evacuation, while a laxative usually produces a soft formed stool over a protracted period; the same drug may act as a laxative or a cathartic depending on the dose administered or individual patient sensitivity. (From AMA Drug Evaluations Annual, 1994, p941)

Top Publications

  1. ncbi Which is the optimal bowel preparation for colonoscopy - a meta-analysis
    J J Y Tan
    Department of Colorectal Surgery, Royal Melbourne Hospital and Epworth Colorectal Centre, Melbourne, Australia
    Colorectal Dis 8:247-58. 2006
  2. ncbi Acute phosphate nephropathy
    Glen S Markowitz
    Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    Kidney Int 76:1027-34. 2009
  3. ncbi Efficacy of prepackaged, low residual test meals with 4L polyethylene glycol versus a clear liquid diet with 4L polyethylene glycol bowel preparation: a randomized trial
    Dong Il Park
    Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea
    J Gastroenterol Hepatol 24:988-91. 2009
  4. ncbi A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation
    A M Soweid
    Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Endoscopy 42:633-8. 2010
  5. ncbi Meta-analysis: the relative efficacy of oral bowel preparations for colonoscopy 1985-2010
    J Belsey
    JB Medical Ltd, The Old Brickworks, Little Cornard, Sudbury, UK
    Aliment Pharmacol Ther 35:222-37. 2012
  6. pmc The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study
    Adolfo Parra-Blanco
    Servicio de Aparato Digestivo, Unidad de Endoscopia 10 a Planta, Hospital Universitario de Canarias, C Ofra s n, 38320 La Laguna, Santa Cruz de Tenerife, Spain
    World J Gastroenterol 12:6161-6. 2006
  7. ncbi Duration of the interval between the completion of bowel preparation and the start of colonoscopy predicts bowel-preparation quality
    Ali A Siddiqui
    Department of Internal Medicine, Dallas Veteran s Affairs Medical Center, Dallas, Texas 75216, USA
    Gastrointest Endosc 69:700-6. 2009
  8. ncbi Patient factors predictive of inadequate bowel preparation using polyethylene glycol: a prospective study in Korea
    Yong Woo Chung
    Department of Gastroenterology, Hallym University Sacred Heart Hospital, Anyang, Korea
    J Clin Gastroenterol 43:448-52. 2009
  9. ncbi Myths and misconceptions about chronic constipation
    Stefan A Müller-Lissner
    Abteilung Innere Medizin, Park Klinik Weissensee, Schönstrasse 80, 13086 Berlin, Germany
    Am J Gastroenterol 100:232-42. 2005
  10. ncbi Adverse effects of laxatives
    J H Xing
    Department of Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dis Colon Rectum 44:1201-9. 2001

Detail Information

Publications206 found, 100 shown here

  1. ncbi Which is the optimal bowel preparation for colonoscopy - a meta-analysis
    J J Y Tan
    Department of Colorectal Surgery, Royal Melbourne Hospital and Epworth Colorectal Centre, Melbourne, Australia
    Colorectal Dis 8:247-58. 2006
    ..To assess which bowel preparation agent is most effective...
  2. ncbi Acute phosphate nephropathy
    Glen S Markowitz
    Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    Kidney Int 76:1027-34. 2009
    ....
  3. ncbi Efficacy of prepackaged, low residual test meals with 4L polyethylene glycol versus a clear liquid diet with 4L polyethylene glycol bowel preparation: a randomized trial
    Dong Il Park
    Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea
    J Gastroenterol Hepatol 24:988-91. 2009
    ....
  4. ncbi A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation
    A M Soweid
    Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Endoscopy 42:633-8. 2010
    ..The incidence of adverse events among patients in the two diet groups was also assessed as a secondary outcome...
  5. ncbi Meta-analysis: the relative efficacy of oral bowel preparations for colonoscopy 1985-2010
    J Belsey
    JB Medical Ltd, The Old Brickworks, Little Cornard, Sudbury, UK
    Aliment Pharmacol Ther 35:222-37. 2012
    ..Previous reviews of bowel preparation for colonoscopy have given contradictory answers...
  6. pmc The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study
    Adolfo Parra-Blanco
    Servicio de Aparato Digestivo, Unidad de Endoscopia 10 a Planta, Hospital Universitario de Canarias, C Ofra s n, 38320 La Laguna, Santa Cruz de Tenerife, Spain
    World J Gastroenterol 12:6161-6. 2006
    ....
  7. ncbi Duration of the interval between the completion of bowel preparation and the start of colonoscopy predicts bowel-preparation quality
    Ali A Siddiqui
    Department of Internal Medicine, Dallas Veteran s Affairs Medical Center, Dallas, Texas 75216, USA
    Gastrointest Endosc 69:700-6. 2009
    ..Recent studies suggest that colonoscopies done in the morning have better-quality bowel preparations than those done in the afternoon...
  8. ncbi Patient factors predictive of inadequate bowel preparation using polyethylene glycol: a prospective study in Korea
    Yong Woo Chung
    Department of Gastroenterology, Hallym University Sacred Heart Hospital, Anyang, Korea
    J Clin Gastroenterol 43:448-52. 2009
    ..This prospective study was designed to look at the quality of colon preparation using polyethylene glycol solution and evaluate potential associations between specific patient characteristics and inadequate bowel preparation...
  9. ncbi Myths and misconceptions about chronic constipation
    Stefan A Müller-Lissner
    Abteilung Innere Medizin, Park Klinik Weissensee, Schönstrasse 80, 13086 Berlin, Germany
    Am J Gastroenterol 100:232-42. 2005
    ..Tolerance to stimulant laxatives is uncommon. There is no indication for the occurrence of "rebound constipation" after stopping laxative intake. While laxatives may be misused, there is no potential for addiction...
  10. ncbi Adverse effects of laxatives
    J H Xing
    Department of Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dis Colon Rectum 44:1201-9. 2001
    ..The link between stimulant laxatives and structural changes, such as the "cathartic colon" or enteric nerve damage, is not well established either. Danthron compounds should be avoided because of hepatotoxicity...
  11. ncbi A randomized, multicenter study comparing the safety and efficacy of sodium phosphate tablets with 2L polyethylene glycol solution plus bisacodyl tablets for colon cleansing
    John F Johanson
    Rockford Gastroenterology Associates, Rockford, Illinois, USA
    Am J Gastroenterol 102:2238-46. 2007
    ..A multicenter, investigator-blinded study was conducted to compare the colon-cleansing efficacy of a new NaP tablet formulation with that of 2L PEG solution plus bisacodyl tablets in adults undergoing colonoscopy...
  12. pmc Colon and rectal surgery without mechanical bowel preparation: a randomized prospective trial
    Oded Zmora
    Department of Surgery, Sheba Medical Center and Sackler School of Medicine, Tel Aviv, Israel
    Ann Surg 237:363-7. 2003
    ..To assess whether elective colon and rectal surgery can be safely performed without preoperative mechanical bowel preparation...
  13. ncbi The timing of bowel preparation is more important than the timing of colonoscopy in determining the quality of bowel cleansing
    Chang Soo Eun
    Department of Internal Medicine, Hanyang University Guri Hospital, Guri si, Gyeonggi Do, Korea
    Dig Dis Sci 56:539-44. 2011
    ....
  14. ncbi Randomized trial of low-volume PEG solution versus standard PEG + electrolytes for bowel cleansing before colonoscopy
    Christian Ell
    Dr Horst Schmidt Kliniken GmbH, Wiesbaden, Germany
    Am J Gastroenterol 103:883-93. 2008
    ..We compared a new 2 L solution of PEG plus ascorbic acid (PEG + Asc) with standard 4 L PEG with electrolytes (PEG + E) for bowel cleansing before colonoscopy to determine efficacy, safety, and patient acceptability...
  15. ncbi Efficacy and tolerance of sodium phosphates oral solution after diet liberalization
    Sherrie R Scott
    Medical Affairs Department, C B Fleet Company, Inc, Lynchburg, Virginia, USA
    Gastroenterol Nurs 28:133-9. 2005
    ..This study supports offering patients a regular breakfast and a low-residue lunch before bowel cleansing with sodium phosphates oral solution...
  16. ncbi The safety of osmotically acting cathartics in colonic cleansing
    Caroline Nyberg
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, 75 Herlev Ringvej, DK 2730 Herlev, Denmark
    Nat Rev Gastroenterol Hepatol 7:557-64. 2010
    ..The osmotically acting cathartics (those given the Anatomical Therapeutic Chemical code A06AD) currently used for this purpose comprise products ..
  17. ncbi Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure
    Glen S Markowitz
    Department of Pathology, Columbia College of Physicians and Surgeons, 630 West 168th Street, Room VC14 224, New York, NY 10032, USA
    J Am Soc Nephrol 16:3389-96. 2005
    ..Potential etiologic factors include inadequate hydration (while receiving OSPS), increased patient age, a history of hypertension, and concurrent use of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker...
  18. ncbi Bowel preparation before colonoscopy in the era of mass screening for colo-rectal cancer: a practical approach
    F Parente
    Gastrointestinal Unit, A Manzoni Hospital, 23900 Lecco, Italy
    Dig Liver Dis 41:87-95. 2009
    ....
  19. ncbi Bowel cleansing for colonoscopy: prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents
    I C Lawrance
    Centre for inflammatory Bowel Diseases, Fremantle Hospital, Alma Street, Fremantle 6059, Western Australia
    Endoscopy 43:412-8. 2011
    ..This study aimed to clarify the differences in efficacy and preparation-induced mucosal inflammation of sodium phosphate (NaP), colonLYTLEY (PEG), and Picoprep (Pico)...
  20. ncbi A prospective randomized blinded comparison of sodium phosphate and polyethylene glycol-electrolyte solution for safe bowel cleansing
    E M H Mathus-Vliegen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 23:543-52. 2006
    ..Polyethylene glycol-electrolyte solution (PEG-ELS) is routinely prescribed for bowel cleansing. Sodium phosphate (NaP) may be an effective but potentially hazardous alternative...
  21. ncbi A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal
    Steven D Wexner
    Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Fla
    Gastrointest Endosc 63:894-909. 2006
  22. ncbi Sodium phosphate is superior to polyethylene glycol in bowel cleansing and shortens the time it takes to visualize colon mucosa
    J Kössi
    Dept of Surgery, Paijat Hame Central Hospital, Lahti, Finland
    Scand J Gastroenterol 38:1187-90. 2003
    ..The aim of this study was to compare the bowel cleansing effect of NaP solution with that of PEG-EL solution and to evaluate whether the cleansing effect correlates with the time needed to perform colonoscopy...
  23. ncbi The influence of mechanical bowel preparation in elective lower colorectal surgery
    Hans Pieter Van't Sant
    Department of Surgery, Ikazia Hospital, Rotterdam, The Netherlands
    Ann Surg 251:59-63. 2010
    ....
  24. pmc A multicentre, observational study of sodium picosulfate and magnesium citrate as a precolonoscopy bowel preparation
    Jonthan Love
    Foothills Medical Centre, Calgary, Alberta
    Can J Gastroenterol 23:706-10. 2009
    ..Despite its frequent use, there are relatively few published studies of this product, especially reports regarding its use in routine clinical practice. Moreover, to date, there have been no Canadian studies of any kind...
  25. pmc Polyethylene glycol vs. sodium phosphate for bowel preparation: a treatment arm meta-analysis of randomized controlled trials
    Ravi Juluri
    Indiana University Health Physicians, Indianapolis, Indiana, USA
    BMC Gastroenterol 11:38. 2011
    ..Results of meta-analyses of randomized trials comparing PEG and NaP are inconsistent and have not included trials comparing either or both preps to less traditional ones...
  26. ncbi Polyethylene glycol versus sodium phosphate in bowel cleansing for colonoscopy: a randomized trial
    G Huppertz-Hauss
    Dept of Gastroenterology, Telemark Hospital, Skien, Norway
    Endoscopy 37:537-41. 2005
    ..The aim of the present study was to compare the effects of three bowel cleansing regimens on subjective well-being, electrolyte balance, cardiac arrhythmia, and the microscopic post-cleansing appearance of the colonic mucosa...
  27. ncbi High-dose senna compared with conventional PEG-ES lavage as bowel preparation for elective colonoscopy: a prospective, randomized, investigator-blinded trial
    Franco Radaelli
    Division of Gastroenterology, Valduce Hospital, Como, Italy
    Am J Gastroenterol 100:2674-80. 2005
    ..To compare the efficacy and patient acceptance of an oral high dose of senna to conventional polyethylene glycol-electrolyte lavage solution (PEG-ES) in adults undergoing elective colonoscopy...
  28. ncbi Tolerability and patient acceptance of sodium phosphate tablets compared with 4-L PEG solution in colon cleansing: combined results of 2 identically designed, randomized, controlled, parallel group, multicenter phase 3 trials
    David Kastenberg
    Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Gastroenterol 41:54-61. 2007
    ..Evaluate patient tolerance and acceptance of a sodium phosphate (NaP) tablet purgative compared with a 4-L polyethylene glycol (PEG) solution...
  29. pmc The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research
    Edwin J Lai
    Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Gastrointest Endosc 69:620-5. 2009
    ..Most scales were intended for comparing oral purgatives and fail to account for washing and/or suctioning by the endoscopist. This limits their utility in studies of colonoscopy outcomes, such as polyp-detection rates...
  30. ncbi A blinded, randomized comparison of a novel, low-dose, triple regimen with fleet phospho-soda: a study of colon cleanliness, speed and success of colonoscopy
    A P Chilton
    Walsgrave Hospital, Coventry, UK
    Endoscopy 32:37-41. 2000
    ..A clean colon is essential for an efficient examination. The aim of this study was to compare a novel low-dose, low volume triple regimen with Fleet Phospho-soda...
  31. ncbi Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing
    Glen S Markowitz
    Department of Pathology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
    Hum Pathol 35:675-84. 2004
    ..Greater awareness of this entity is needed to identify potential risk factors...
  32. ncbi Severe hyperphosphataemia and associated electrolyte and metabolic derangement following the administration of sodium phosphate for bowel preparation
    H L Tan
    Department of Anaesthesiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    Anaesthesia 57:478-83. 2002
    ..We report six cases of severe electrolyte and metabolic derangement due to sodium phosphate bowel preparation: two patients had delayed awakening from general anaesthesia, and four patients suffered life-threatening consequences...
  33. ncbi The safety profile of oral sodium phosphate for colonic cleansing before colonoscopy in adults
    Lawrence C Hookey
    Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen s University, Kingston, Ontario, Canada
    Gastrointest Endosc 56:895-902. 2002
  34. ncbi A randomized, blinded, prospective trial to compare the safety and efficacy of three bowel-cleansing solutions for colonoscopy (HSG-01*)
    C Ell
    Dept of Internal Medicine II, Dr Horst Schmidt Hospital Teaching Hospital of the Johannes Gutenberg University of Mainz, Wiesbaden, Germany
    Endoscopy 35:300-4. 2003
    ....
  35. ncbi The bowel cleansing for colonoscopy. A randomized trial comparing three methods
    Luigi De Salvo
    Dipartimento di Discipline Chirurgiche, Morfologiche e Metodologie Integrate DiCMI, Universita degli Studi di Genova, Italy
    Ann Ital Chir 77:143-6; discussion 147. 2006
    ..So far several regimens have been proposed but rather none has shown a clear-cut advantage over the others. Aim of this study was to compare cleansing ability and patients' compliance of three oral regimens...
  36. ncbi Association between oral sodium phosphate bowel preparations and kidney injury: a systematic review and meta-analysis
    Steven M Brunelli
    Renal, Electrolyte, and Hypertension Division and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Kidney Dis 53:448-56. 2009
    ..Case reports and series have suggested an association between oral sodium phosphate bowel preparations and kidney injury. Results of analytic studies have been mixed...
  37. ncbi A prospective assessment of renal impairment after preparation for colonoscopy: oral sodium phosphate appears to be safe in well-hydrated subjects with normal renal status
    M A Korsten
    RR and D Center of Excellence for Medical Consequences of SCI, James J Peters VA Medical Center, Bronx, NY, USA
    Dig Dis Sci 55:2021-9. 2010
    ..However, the safety of administering OSPS prior to colonoscopy has been questioned because of the potential for renal failure...
  38. ncbi CT colonography with fecal tagging after incomplete colonoscopy
    S Gryspeerdt
    Department of Radiology, Stedelijk Ziekenhuis, Roeselare, Belgium
    Eur Radiol 15:1192-202. 2005
    ..Compared with ScCl, FT reduces fluid, favors distention, but suffers from fecal residues. The tagged nature of these residues, however, allows differentiation from polyps...
  39. ncbi Effects of sennosides and nonanthranoid laxatives on cytochemistry of epithelial cells in rat colon
    K Yang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, N Y 10021
    Pharmacology 47:196-204. 1993
    ..Cytokeratin AE1 expression increased on picosulfate and sennosides. SBA total binding increased on bisacodyl and picosulfate. The present findings were thought to be of functional origin and do not represent early precancerous lesions...
  40. ncbi Computed tomographic colonography without cathartic preparation for the detection of colorectal polyps
    Riccardo Iannaccone
    Department of Radiological Sciences, University of Rome, Rome, Italy
    Gastroenterology 127:1300-11. 2004
    ..We prospectively compared the performance of low-dose multidetector computed tomographic colonography (CTC) without cathartic preparation with that of colonoscopy for the detection of colorectal polyps...
  41. ncbi CT colonography with limited bowel preparation: performance characteristics in an increased-risk population
    Sebastiaan Jensch
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands
    Radiology 247:122-32. 2008
    ..To prospectively evaluate the sensitivity and specificity of computed tomographic (CT) colonography with limited bowel preparation for the depiction of colonic polyps, by using colonoscopy as the reference standard...
  42. ncbi Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solution
    Wai Lun Law
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Asian J Surg 27:120-4. 2004
    ..To compare three bowel preparation regimens for colonoscopy in terms of the quality of preparation, the side effects and patient acceptance...
  43. ncbi Oral sodium phosphate compared with water enemas combined with bisacodyl as bowel preparation for elective colonoscopy
    M Rasmussen
    Dept of Surgery A, Odense University Hospital, Odense, Denmark
    Scand J Gastroenterol 38:1090-4. 2003
    ....
  44. ncbi Low volume bowel preparation for colonoscopy: randomized, endoscopist-blinded trial of liquid sodium phosphate versus tablet sodium phosphate
    David H Balaban
    Charlottesville Gastroenterology Associates, Charlottesville, Virginia 22902, USA
    Am J Gastroenterol 98:827-32. 2003
    ..The aim of this study was to compare the colon-cleansing effectiveness, ease of consumption, and side effect profiles of two commercially available preparations of sodium phosphate: liquid Fleet Phospho-soda and Visicol tablets...
  45. ncbi Safety and colon-cleansing efficacy of a new residue-free formulation of sodium phosphate tablets
    Douglas K Rex
    Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 101:2594-604. 2006
    ..A multicenter, randomized, investigator-blinded study was conducted to compare the colon-cleansing efficacy of 40 or 32 tablets of RF-NaP with the marketed 40-tablet NaP treatment regimen...
  46. ncbi Prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparation
    Kai Lin Hwang
    Department of Public Health, Chung Shan Medical University, Taichung, Taiwan, China
    World J Gastroenterol 11:7486-93. 2005
    ..To compare the effectiveness, patient acceptability, and physical tolerability of two oral lavage solutions prior to colonoscopy in a Taiwanese population...
  47. ncbi Acute phosphate nephropathy and renal failure
    Simon Desmeules
    N Engl J Med 349:1006-7. 2003
  48. ncbi Comparison of reduced volume versus four-liter electrolyte lavage solutions for colon cleansing
    Tim S Ker
    University of Southern California, Los Angeles, USA
    Am Surg 72:909-11. 2006
    ..3 per cent. The study that found the 2-liter electrolyte lavage solution with four tablets of bisacodyl can achieve equally good results in bowel preparation and favorable acceptance by patients compared with the 4-liter lavage...
  49. pmc Effect of four-day psyllium supplementation on bowel preparation for colonoscopy:A prospective double blind randomized trial [ISRCTN76623768]
    Walter A Salwen
    Wayne State University, Detroit MI, John D, Dingell VAMC, Detroit, MI, USA
    BMC Gastroenterol 4:2. 2004
    ..We sought to determine whether preliminary fiber supplementation would alter the tolerability or efficacy of a standard bowel preparation for colonoscopy..
  50. ncbi Differentiating functional constipation from constipation-predominant irritable bowel syndrome: management implications
    Nicholas J Talley
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Rev Gastroenterol Disord 5:1-9. 2005
    ..In this article, the author presents a review of the management implications of differentiating constipation-predominant IBS from functional constipation...
  51. ncbi Efficacy and safety of sodium phosphate for colon cleansing in type 2 diabetes mellitus
    Nevin Akcaer Ozturk
    Department of Gastroenterology, Faculty of Medicine, Baskent University, Konya, Turkey
    South Med J 103:1097-102. 2010
    ..In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), and the quality of bowel cleansing in relation to glycemic control and late complications...
  52. pmc Colon cleansing before colonoscopy: does oral sodium phosphate solution still make sense?
    D K Rex
    Indiana University Medical Center, Indianapolis, USA
    Can J Gastroenterol 23:210-4. 2009
    ..Candidate patients for oral NaP solution should be assessed for eligibility and preparation instructions should adhere to the current recommendations for maximizing the safety of oral NaP...
  53. ncbi Updated systematic review and meta-analysis of randomized clinical trials on the role of mechanical bowel preparation before colorectal surgery
    Karem Slim
    Department of General and Digestive Surgery, Hotel Dieu, Clermont Ferrand, France
    Ann Surg 249:203-9. 2009
    ..Therefore, an updated large meta-analysis was conducted to re-evaluate the role of MBP in colorectal surgery. Furthermore, the influence of different kind of MBP regimes on infectious outcomes was examined...
  54. ncbi A prospective randomized trial comparing low-dose oral sodium phosphate plus stimulant laxatives with large volume polyethylene glycol solution for colon cleansing
    Lawrence C Hookey
    Gastrointestinal Diseases Research Unit, Queen s University, Kingston, Ontario, Canada
    Am J Gastroenterol 99:2217-22. 2004
    ..These findings suggest that FPK #3 is better tolerated and as safe as PEG but does not provide more efficacious cleansing of the colon...
  55. ncbi Willingness to undergo split-dose bowel preparation for colonoscopy and compliance with split-dose instructions
    R Zackary Unger
    Department of Medicine, Division of Gastroenterology Hepatology, Indiana University Medical Center, Indianapolis, IN, USA
    Dig Dis Sci 55:2030-4. 2010
    ..Some physicians believe that split-dose preparations would be unpopular with patients scheduled for early morning colonoscopies...
  56. pmc Combined low volume polyethylene glycol solution plus stimulant laxatives versus standard volume polyethylene glycol solution: a prospective, randomized study of colon cleansing before colonoscopy
    Lawrence C Hookey
    Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario
    Can J Gastroenterol 20:101-5. 2006
    ..The aim of the present study was to determine whether a reduced volume of PEG combined with stimulant laxatives would be better tolerated and as or more effective than the standard dose...
  57. ncbi Reasons for poor colonic preparation with inpatients
    Timothy Reilly
    University Hospital at Stony Brook, Department of Gastroenterology and Hepatology, Stony Brook, NY 11794 8173, USA
    Gastroenterol Nurs 27:115-7. 2004
    ..The best results were obtained when the colonoscopy procedure was conducted within 6-11 hours of bowel preparation completion...
  58. ncbi Residue-free sodium phosphate tablets (OsmoPrep) versus Visicol for colon cleansing: a randomized, investigator-blinded trial
    Lawrence Wruble
    Memphis Gastroenterology Group, Memphis, TN 38120, USA
    Gastrointest Endosc 65:660-70. 2007
    ..The bowel purgative Visicol contains microcrystalline cellulose (MCC) residue, which may impair full visibility during a colonoscopy. An MCC residue-free sodium phosphate (RF-NaP; OsmoPrep) tablet was developed...
  59. ncbi Socioeconomic and other predictors of colonoscopy preparation quality
    Benjamin Lebwohl
    Division of Digestive and Liver Disease, Columbia University, New York, NY 10032, USA
    Dig Dis Sci 55:2014-20. 2010
    ..Established risk factors for suboptimal bowel preparation have been proposed, but social factors, such as socioeconomic status and marital status, have not been investigated...
  60. ncbi Bowel preparation for colonoscopy in very old patients: a randomized prospective trial comparing oral sodium phosphate and polyethylene glycol electrolyte lavage solution
    L Seinelä
    Services for Elderly People, City of Tampere, Tampere, Finland
    Scand J Gastroenterol 38:216-20. 2003
    ..Colonoscopic preparations are defectively tolerated among many very old patients and the quality of preparation is often inadequate...
  61. ncbi A randomized clinical study evaluating the safety and efficacy of a new, reduced-volume, oral sulfate colon-cleansing preparation for colonoscopy
    Jack A Di Palma
    Division of Gastroenterology, College of Medicine, University of South Alabama, Mobile, Alabama 36693, USA
    Am J Gastroenterol 104:2275-84. 2009
    ..We sought to evaluate a new, low-volume, oral sulfate solution as a bowel preparation for colonoscopy in adult patients...
  62. ncbi A prospective study to assess the efficacy and patient tolerance of three bowel preparations for colonoscopy
    Roderick Rapier
    Southern California Kaiser Permanente Medical Center, Division of Gastroenterology, San Diego, California, USA
    Gastroenterol Nurs 29:305-8. 2006
    ..This study suggests that a low-residue diet kit, given in conjunction with polyethylene glycol electrolyte or magnesium citrate and bisacodyl, produces adequate colon cleansing and patient tolerability...
  63. ncbi The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on serum electrolytes and hemodynamics
    V K Sharma
    Department of Internal Medicine, University of South Carolina, Columbia, USA
    J Clin Gastroenterol 32:238-9. 2001
    ..Two liters of PEG-ELS with a stimulant laxative is safe and effective for colonoscopy...
  64. pmc Single blind, randomised trial of efficacy and acceptability of oral picolax versus self administered phosphate enema in bowel preparation for flexible sigmoidoscopy screening
    W S Atkin
    Imperial Cancer Research Fund Colorectal Cancer Unit, St Mark s Hospital, Northwick Park, Harrow HA1 3UJ
    BMJ 320:1504-8; discussion 1509. 2000
    ..To compare the acceptability and efficacy of two methods of self administered bowel preparation for flexible sigmoidoscopy screening: a single phosphate enema and a single sachet of Picolax...
  65. ncbi Assessing attitudes toward laxative preparation in colorectal cancer screening and effects on future testing: potential receptivity to computed tomographic colonography
    Timothy J Beebe
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:666-71. 2007
    ..The overall response rate was 49%. Analysis focused on the 759 respondents who were 50 years or older...
  66. ncbi Acute phosphate nephropathy following oral sodium phosphate solution to cleanse the bowel for colonoscopy
    Annette Beyea
    Department of Internal Medicine, Section of Nephrology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Kidney Dis 50:151-4. 2007
  67. ncbi Mechanical bowel preparation or not? Outcome of a multicenter, randomized trial in elective open colon surgery
    Patrick Fa-Si-Oen
    Department of Surgery, Maxima Medical Center, Veldhoven, The Netherlands
    Dis Colon Rectum 48:1509-16. 2005
    ..In recent literature the value of this procedure is under discussion. To verify the value of mechanical bowel preparation in elective open colon surgery, a randomized clinical trial was conducted...
  68. ncbi Is mechanical bowel preparation mandatory for elective colon surgery? A prospective randomized study
    Edward Ram
    Division of General Surgery, Rabin Medical Center, Campus Golda, Petach Tikva Sackler Medical School, Tel Aviv University, Tel Aviv, Israel
    Arch Surg 140:285-8. 2005
    ..It was assumed that with the improvement in surgical technique together with the use of more effective prophylactic antibiotics, it was possible that MBP would no longer be necessary...
  69. ncbi Hyperphosphataemia after bowel preparation with oral sodium phosphate
    E J Ainley
    Endoscopy 38:759. 2006
  70. ncbi Trends in preparation for colorectal surgery: survey of the members of the American Society of Colon and Rectal Surgeons
    Oded Zmora
    Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA
    Am Surg 69:150-4. 2003
    ..There is a trend toward the use of a shorter course of postoperative intravenous antibiotics and the use of sodium phosphate for mechanical cleansing...
  71. ncbi Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing: clinical patterns and renal biopsy findings
    Gulfiliz Gonlusen
    Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, Texas, USA
    Arch Pathol Lab Med 130:101-6. 2006
    ..The renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The renal failure improved at least partially in most of these patients, but persisted in rare cases...
  72. pmc CT colonography: optimisation, diagnostic performance and patient acceptability of reduced-laxative regimens using barium-based faecal tagging
    Stuart A Taylor
    Department of Specialist Radiology, University College Hospital, Euston Road, London, UK
    Eur Radiol 18:32-42. 2008
    ..Reduced preparation was tolerated better than full endoscopic preparation by 61%. Reduced-laxative CTC with three doses of 20 ml 40% barium sulphate is as effective as more complex regimens, retaining adequate diagnostic accuracy...
  73. ncbi Management of opioid-induced constipation
    D M Thorpe
    Pain Medicine and Palliative Care, The Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 2100, Salt Lake City, UT 84112, USA
    Curr Pain Headache Rep 5:237-40. 2001
    ....
  74. ncbi Kidney biopsies taken before and after oral sodium phosphate bowel cleansing
    Willy Aasebø
    Medical Department, Akershus University Hospital, NO 1478 Lørenskog, Norway
    Nephrol Dial Transplant 22:920-2. 2007
  75. ncbi Optimizing bowel preparation for multidetector row CT colonography: effect of Citramag and Picolax
    S A Taylor
    Department of Intestinal Imaging, St Mark s Hospital, Northwick Park, London, UK
    Clin Radiol 58:723-32. 2003
    ..To compare the adequacy and acceptability of Picolax and Citramag bowel cleansing agents for CT colonography...
  76. ncbi Incidence, prevalence, and management of opioid bowel dysfunction
    M Pappagallo
    New York University School of Medicine, Hospital for Joint Diseases, New York, New York 10003, USA
    Am J Surg 182:11S-18S. 2001
    ..With a better understanding of the prevalence of OBD and its pathophysiology, a more aggressive approach to preventing and treating OBD is possible and will likely improve the quality of life of patients with pain...
  77. pmc The use of mechanical bowel preparation in elective colorectal surgery
    Alison S McCoubrey
    Department of Surgery, Antrim Area Hospital, Antrim BT41 2RL, United Kingdom
    Ulster Med J 76:127-30. 2007
    ..A literature search was undertaken to ascertain the evidence available regarding the use of MBP in elective colorectal surgery...
  78. ncbi Mechanical bowel preparation for elective colorectal surgery: a meta-analysis
    Pascal Bucher
    Clinic of Visceral and Transplantation Surgery, Department of Surgery and Division of Medical Statistics, Geneva University Hospital, Geneva, Switzerland
    Arch Surg 139:1359-64; discussion 1365. 2004
    ..There is little scientific evidence to support the routine practice of mechanical bowel preparation (MBP) before elective colorectal surgery in order to minimize the risk of postoperative septic complications...
  79. ncbi Right hemicolectomy: mechanical bowel preparation is not required
    J O Jansen
    Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, UK
    J R Coll Surg Edinb 47:557-60. 2002
    ..This study examines the outcome of a policy of no mechanical preparation before elective right hemicolectomy...
  80. ncbi Oral sodium phosphate solution: a review of its use as a colorectal cleanser
    Monique P Curran
    Adis International Limited, Auckland, New Zealand
    Drugs 64:1697-714. 2004
    ..The decrease in serum potassium levels after administration of oral sodium phosphate solution was negatively correlated with baseline intracellular potassium levels...
  81. ncbi Dietary fecal tagging as a cleansing method before CT colonography: initial results polyp detection and patient acceptance
    Philippe A Lefere
    Department of Radiology, Stedelijk Ziekenhuis, Bruggesteenweg 90, 8800 Roeselare, Belgium
    Radiology 224:393-403. 2002
    ..To compare reduced colonic cleansing based on dietary fecal tagging (FT) with standard (non-FT) colonic cleansing with regard to patient acceptance, sensitivity, and specificity...
  82. doi Case records of the Massachusetts General Hospital. Case 27-2008. A 64-year-old man with abdominal pain, nausea, and an elevated level of serum creatinine
    Theodore I Steinman
    Renal Division, Beth Israel Deaconess Medical Center, Boston, USA
    N Engl J Med 359:951-60. 2008
  83. ncbi Noncathartic CT colonography with stool tagging: performance with and without electronic stool subtraction
    C Daniel Johnson
    Department of Radiology, Mayo Clinic, 13400 E Shea Blve, Scottsdale, AZ 85259, USA
    AJR Am J Roentgenol 190:361-6. 2008
    ....
  84. doi Acute phosphate nephropathy after sodium phosphate preparations
    Andrew Connor
    Department of Renal Medicine, Dorset County Hospital, Dorchester DT1 2JY
    BMJ 337:a182. 2008
  85. ncbi Effect of oral purgatives on gastric and small bowel transit time in capsule endoscopy
    Zvi Fireman
    Departments of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
    Isr Med Assoc J 6:521-3. 2004
    ....
  86. ncbi The effect of mechanical bowel preparation on human colonic tissue in elective open colon surgery
    Patrick R Fa-Si-Oen
    Dis Colon Rectum 47:948-9. 2004
  87. ncbi Risk of further decline in renal function after the use of oral sodium phosphate or polyethylene glycol in patients with a preexisting glomerular filtration rate below 60 ml/min
    Stefan Russmann
    The Degge Group, Arlington, Virginia 22209, USA
    Am J Gastroenterol 103:2707-16. 2008
    ....
  88. ncbi Is mechanical bowel preparation really necessary in colorectal surgery?
    Maqbool Ahmad
    Department of Surgery, Combined Military Hospital, Pano Aqil Cantt
    J Coll Physicians Surg Pak 13:637-9. 2003
    ..To determine the outcome of colorectal surgery without mechanical bowel preparation...
  89. ncbi Renal failure following bowel cleansing with a sodium phosphate purgative
    Glen S Markowitz
    Nephrol Dial Transplant 20:850-1. 2005
  90. ncbi Renal failure due to acute phosphate nephropathy
    T M Slee
    Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands
    Neth J Med 66:438-41. 2008
    ..It could even be argued that these drugs should not be prescribed at all...
  91. ncbi An easily overlooked iatrogenic cause of renal failure
    N Demoulin
    Department of Nephrology, Cliniques Universitaires St Luc, Université Catholique de Louvain Medical School, Brussels, Belgium
    Clin Nephrol 70:176-7. 2008
    ..The patient had residual renal impairment at 8-month follow-up. Greater awareness of this complication is needed amongst health care professionals. The preventive strategies are discussed...
  92. ncbi CT colonography after fecal tagging with a reduced cathartic cleansing and a reduced volume of barium
    Philippe Lefere
    Department of Radiology, Stedelijk Ziekenhuis, Bruggesteenweg 90, Roeselare B 8800, Belgium
    AJR Am J Roentgenol 184:1836-42. 2005
    ..The objective of our study was to assess the efficacy of fecal tagging with a small volume of barium in combination with a reduced cathartic cleansing before CT colonography...
  93. ncbi Assessing and managing opiate-induced constipation in adults with cancer
    Susan C McMillan
    University of South Florida College of Nursing, Tampa, FL 33612, USA
    Cancer Control 11:3-9. 2004
  94. ncbi Association of oral sodium phosphate purgative use with acute kidney injury
    Frank P Hurst
    Nephrology Service, US Army, Walter Reed Army Medical Center, Washington, DC 20307, USA
    J Am Soc Nephrol 18:3192-8. 2007
    ....
  95. ncbi Validation of a new scale for the assessment of bowel preparation quality
    Alaa Rostom
    Division of Gastroenterology, The Ottawa Hospital Civic Campus, University of Ottawa, Ottawa, Canada
    Gastrointest Endosc 59:482-6. 2004
    ..A new colonoscopy bowel preparation scale (the Ottawa bowel preparation scale) was developed and validated prospectively...
  96. ncbi CT colonography without cathartic preparation: feasibility study
    M R Callstrom
    Department of Diagnostic Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Radiology 219:693-8. 2001
    ..Sensitivity for polyp detection in patients with adequate stool labeling approaches the sensitivity for polyp detection in prepared colons...
  97. ncbi Comparison of standard polyethylene glycol and two doses of oral sodium phosphate solution in precolonoscopy bowel preparation: a randomized controlled trial
    M Picchio
    Department of Surgery, Civil Hospital A Fiorini, Latina, Italy
    Acta Gastroenterol Belg 71:15-20. 2008
    ..This study was undertaken to compare the efficacy, side effects and patient acceptance of standard 4-liters polyethylene glycol (PEG) and 2 doses of sodium phosphate (NaP) solution for precolonoscopy colon cleansing...
  98. ncbi When the going gets tough: pediatric constipation and encopresis
    Lisa Philichi
    Gastroenterology Clinic, Mary Bridge Children s Hospital and Health Center, 311 South L St, MS 311 W3 GI, Tacoma, WA 98405, USA
    Gastroenterol Nurs 31:121-30. 2008
    ..To successfully treat these disorders, a combination of family education, disimpaction and maintenance medications, a well-balanced diet, and behavior management is essential...
  99. ncbi Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial
    Hsiao Ling Chen
    Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan 402
    J Am Coll Nutr 27:102-8. 2008
    ..In addition, the mechanisms by which KGM modulated the bowel habit were explored...
  100. doi Purging the colon while preserving the kidneys
    Hemant K Roy
    Arch Intern Med 168:565-7. 2008
  101. ncbi Management principles of organic causes of childhood constipation
    Nan Tobias
    Cincinnati Children s Hospital, Division of Urology, 3333 Burnet Ave, MLC 5037, Cincinnati, Ohio 45229, USA
    J Pediatr Health Care 22:12-23. 2008
    ..Children and adolescents who experience bowel dysfunction require patience and sensitive support from their health care providers so that they can live productive and emotionally healthy lives...

Research Grants23

  1. DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
    ALAN HOFMANN; Fiscal Year: 2005
    ..indicates that endogenous C24 dihydroxy- bile acids (chenodeoxycholic and/or deoxycholic acid) act as natural cathartics by inducing colonic secretion and colonic propulsion...
  2. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  3. PROSPECTIVE COMPARISON OF COLONIC IMAGING TEST
    Don Rockey; Fiscal Year: 2001
    ..The information gained from this study is expected to form the basis for national policy and decision making with reward to colonic imaging tests. ..
  4. Regulation of Stellate Cell Contractility
    Don Rockey; Fiscal Year: 2008
    ..Physiologic endpoints will be an important focus. The proposed studies will shed light on the molecular basis of stellate cell contractility and moreover have direct relevance to human liver disease. ..
  5. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  6. PATHOGENESIS OF HEPATIC FIBROSIS AND PORTAL HYPERTENSION
    Don C Rockey; Fiscal Year: 2010
    ..These studies have direct relevance to human liver disease and will lead to new approaches for the treatment of hepatic fibrosis and portal hypertension as well as other forms of fibrosing injury. ..
  7. Nitric Oxide and the Liver
    Don Rockey; Fiscal Year: 2003
    ..The dates of the entire AASLD scientific meeting are November 3rd to November 5th. The participants will be invited speakers and attendees of the annual 2002 AASLD meeting. ..
  8. Using Risk to Tailor Management of Digestive Diseases
    Thomas Imperiale; Fiscal Year: 2008
    ..abstract_text> ..
  9. Quantifying Risk to Target Screening Colonoscopy
    Thomas Imperiale; Fiscal Year: 2009
    ..The knowledge generated by this research will help maximize prevention and minimize the morbidity and cost of CRC screening. ..
  10. CTC of the Unprepped Colon: Optimization and Validation
    C Johnson; Fiscal Year: 2006
    ..Data generated should provide for a balanced appraisal of the value and practicality of this revolutionary and potentially powerful unique screening tool. ..
  11. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  12. 5-Year Survival Following Injury in Geriatric Patients
    Laura Criddle; Fiscal Year: 2006
    ..Contribution: This foundational study will provide basic information about the survival patterns of injured elders as a basis for the development of interventions to improve geriatric survival. [unreadable] [unreadable] [unreadable]..
  13. Outcome of Adolescent-Onset Eating Disorders
    Anna Bardone Cone; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  14. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  15. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  16. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  17. Opioid Receptor Imaging by PET in Bulimia Nervosa
    ANGELA GUARDA; Fiscal Year: 2005
    ..abstract_text> ..
  18. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
  19. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  20. Colon Polyp Screening with Colonoscopy in Women
    Philip Schoenfeld; Fiscal Year: 2005
    ..Ultimately, the proposed research studies, didactic coursework, and mentoring hopefully will lead to successful R01 applications. ..
  21. Bupropion SR as an Anti-Craving Anti-Obesity Agent
    Kristine Steffen; Fiscal Year: 2008
    ..Longer term implications for the results of this study include the potential investigation of this agent as a therapeutic intervention for conditions such as obesity and binge eating disorder. [unreadable] [unreadable] [unreadable]..