Genomes and Genes
Summary: Agents that promote and/or ease defecation by accelerating the passage of feces through the large intestine, by influencing the consistency and amount of stool, and by facilitating the elimination of feces from the rectum. The terms laxative and cathartic reflect the typical intensity and latency of effect. A cathartic usually produces prompt fluid evacuation, while a laxative usually produces a soft formed stool over a protracted period; the same drug may act as a laxative or a cathartic depending on the dose administered or individual patient sensitivity. (From AMA Drug Evaluations Annual, 1994, p941)
Publications176 found, 100 shown here
- Which is the optimal bowel preparation for colonoscopy - a meta-analysisJ J Y Tan
Department of Colorectal Surgery, Royal Melbourne Hospital and Epworth Colorectal Centre, Melbourne, Australia
Colorectal Dis 8:247-58. 2006..Patients have more difficulty completing PEG than NaP and SPS. Biochemical changes associated with a small-volume preparation like NaP, albeit largely asymptomatic, mandate caution in patients with cardiovascular or renal impairment...
- A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American GastrointestinalSteven D Wexner
Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Fla
Gastrointest Endosc 63:894-909. 2006
- Comparison of reduced volume versus four-liter electrolyte lavage solutions for colon cleansingTim S Ker
University of Southern California, Los Angeles, USA
Am Surg 72:909-11. 2006..3 per cent. The study that found the 2-liter electrolyte lavage solution with four tablets of bisacodyl can achieve equally good results in bowel preparation and favorable acceptance by patients compared with the 4-liter lavage...
- The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized studyAdolfo Parra-Blanco
Servicio de Aparato Digestivo, Unidad de Endoscopia 10 a Planta, Hospital Universitario de Canarias, C Ofra s n, 38320 La Laguna, Santa Cruz de Tenerife, Spain
World J Gastroenterol 12:6161-6. 2006....
- Prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparationKai-Lin Hwang
Department of Public Health, Chung-Shan Medical University, Taichung, Taiwan, China
World J Gastroenterol 11:7486-93. 2005..After identifying and excluding patients with potential risk factors, sodium phosphate should become an alternative preparation for patients undergoing elective colonoscopy in the Taiwanese population...
- A prospective randomized trial comparing low-dose oral sodium phosphate plus stimulant laxatives with large volume polyethylene glycol solution for colon cleansingLawrence C Hookey
Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada
Am J Gastroenterol 99:2217-22. 2004..These findings suggest that FPK #3 is better tolerated and as safe as PEG but does not provide more efficacious cleansing of the colon...
- Acute phosphate nephropathy and renal failureSimon Desmeules
N Engl J Med 349:1006-7. 2003
- The bowel cleansing for colonoscopy. A randomized trial comparing three methodsLuigi De Salvo
Dipartimento di Discipline Chirurgiche, Morfologiche e Metodologie Integrate DiCMI, Universita degli Studi di Genova, Italy
Ann Ital Chir 77:143-6; discussion 147. 2006..So far several regimens have been proposed but rather none has shown a clear-cut advantage over the others. Aim of this study was to compare cleansing ability and patients' compliance of three oral regimens...
- Polyethylene glycol versus sodium phosphate in bowel cleansing for colonoscopy: a randomized trialG Huppertz-Hauss
Dept of Gastroenterology, Telemark Hospital, Skien, Norway
Endoscopy 37:537-41. 2005..The aim of the present study was to compare the effects of three bowel cleansing regimens on subjective well-being, electrolyte balance, cardiac arrhythmia, and the microscopic post-cleansing appearance of the colonic mucosa...
- Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solutionWai Lun Law
Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
Asian J Surg 27:120-4. 2004..To compare three bowel preparation regimens for colonoscopy in terms of the quality of preparation, the side effects and patient acceptance...
- Safety and colon-cleansing efficacy of a new residue-free formulation of sodium phosphate tabletsDouglas K Rex
Indiana University Medical Center, Indianapolis, Indiana 46202, USA
Am J Gastroenterol 101:2594-604. 2006..CONCLUSIONS: Based on the safety, efficacy, and patient preferences, the 32-tablet RF-NaP regimen was superior to the 40-tablet RF-NaP and NaP regimen for colon cleansing prior to colonoscopy...
- Oral sodium phosphate compared with water enemas combined with bisacodyl as bowel preparation for elective colonoscopyM Rasmussen
Dept of Surgery A, Odense University Hospital, Odense, Denmark
Scand J Gastroenterol 38:1090-4. 2003....
- Tolerability and patient acceptance of sodium phosphate tablets compared with 4-L PEG solution in colon cleansing: combined results of 2 identically designed, randomized, controlled, parallel group, multicenter phase 3 trialsDavid Kastenberg
Thomas Jefferson University, Philadelphia, PA 19107, USA
J Clin Gastroenterol 41:54-61. 2007..Evaluate patient tolerance and acceptance of a sodium phosphate (NaP) tablet purgative compared with a 4-L polyethylene glycol (PEG) solution...
- Combined low volume polyethylene glycol solution plus stimulant laxatives versus standard volume polyethylene glycol solution: a prospective, randomized study of colon cleansing before colonoscopyLawrence C Hookey
Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario
Can J Gastroenterol 20:101-5. 2006..The aim of the present study was to determine whether a reduced volume of PEG combined with stimulant laxatives would be better tolerated and as or more effective than the standard dose...
- Effect of four-day psyllium supplementation on bowel preparation for colonoscopy:A prospective double blind randomized trial [ISRCTN76623768]Walter A Salwen
Wayne State University, Detroit MI, John D, Dingell VAMC, Detroit, MI, USA
BMC Gastroenterol 4:2. 2004..We sought to determine whether preliminary fiber supplementation would alter the tolerability or efficacy of a standard bowel preparation for colonoscopy..
- Validation of a new scale for the assessment of bowel preparation qualityAlaa Rostom
Division of Gastroenterology, The Ottawa Hospital-Civic Campus, University of Ottawa, Ottawa, Canada
Gastrointest Endosc 59:482-6. 2004..89: 95% CI[0.83, 0.92]. CONCLUSIONS: The Ottawa scale was validated prospectively and demonstrates high interobserver agreement and reliability, whether used as a total score or for individual colon segments...
- High-dose senna compared with conventional PEG-ES lavage as bowel preparation for elective colonoscopy: a prospective, randomized, investigator-blinded trialFranco Radaelli
Division of Gastroenterology, Valduce Hospital, Como, Italy
Am J Gastroenterol 100:2674-80. 2005..To compare the efficacy and patient acceptance of an oral high dose of senna to conventional polyethylene glycol-electrolyte lavage solution (PEG-ES) in adults undergoing elective colonoscopy...
- Differentiating functional constipation from constipation-predominant irritable bowel syndrome: management implicationsNicholas J Talley
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Rev Gastroenterol Disord 5:1-9. 2005..In this article, the author presents a review of the management implications of differentiating constipation-predominant IBS from functional constipation...
- Adverse effects of laxativesJ H Xing
Department of Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Dis Colon Rectum 44:1201-9. 2001..The link between stimulant laxatives and structural changes, such as the "cathartic colon" or enteric nerve damage, is not well established either. Danthron compounds should be avoided because of hepatotoxicity...
- The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented researchEdwin J Lai
Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts 02118, USA
Gastrointest Endosc 69:620-5. 2009..Most scales were intended for comparing oral purgatives and fail to account for washing and/or suctioning by the endoscopist. This limits their utility in studies of colonoscopy outcomes, such as polyp-detection rates...
- Socioeconomic and other predictors of colonoscopy preparation qualityBenjamin Lebwohl
Division of Digestive and Liver Disease, Columbia University, New York, NY 10032, USA
Dig Dis Sci 55:2014-20. 2010..Established risk factors for suboptimal bowel preparation have been proposed, but social factors, such as socioeconomic status and marital status, have not been investigated...
- A randomized, multicenter study comparing the safety and efficacy of sodium phosphate tablets with 2L polyethylene glycol solution plus bisacodyl tablets for colon cleansingJohn F Johanson
Rockford Gastroenterology Associates, Rockford, Illinois, USA
Am J Gastroenterol 102:2238-46. 2007..A multicenter, investigator-blinded study was conducted to compare the colon-cleansing efficacy of a new NaP tablet formulation with that of 2L PEG solution plus bisacodyl tablets in adults undergoing colonoscopy...
- Low volume bowel preparation for colonoscopy: randomized, endoscopist-blinded trial of liquid sodium phosphate versus tablet sodium phosphateDavid H Balaban
Charlottesville Gastroenterology Associates, Charlottesville, Virginia 22902, USA
Am J Gastroenterol 98:827-32. 2003..04). CONCLUSIONS: Liquid sodium phosphate is better tolerated and more effective at colon cleansing when compared with sodium phosphate in tablet form...
- The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on serum electrolytes and hemodynamicsV K Sharma
Department of Internal Medicine, University of South Carolina, Columbia, USA
J Clin Gastroenterol 32:238-9. 2001..Two liters of PEG-ELS with a stimulant laxative is safe and effective for colonoscopy...
- Patient factors predictive of inadequate bowel preparation using polyethylene glycol: a prospective study in KoreaYong Woo Chung
Department of Gastroenterology, Hallym University Sacred Heart Hospital, Anyang, Korea
J Clin Gastroenterol 43:448-52. 2009..This prospective study was designed to look at the quality of colon preparation using polyethylene glycol solution and evaluate potential associations between specific patient characteristics and inadequate bowel preparation...
- Randomized trial of low-volume PEG solution versus standard PEG + electrolytes for bowel cleansing before colonoscopyChristian Ell
Dr Horst Schmidt Kliniken GmbH, Wiesbaden, Germany
Am J Gastroenterol 103:883-93. 2008..We compared a new 2 L solution of PEG plus ascorbic acid (PEG + Asc) with standard 4 L PEG with electrolytes (PEG + E) for bowel cleansing before colonoscopy to determine efficacy, safety, and patient acceptability...
- A prospective study to assess the efficacy and patient tolerance of three bowel preparations for colonoscopyRoderick Rapier
Southern California Kaiser Permanente Medical Center, Division of Gastroenterology, San Diego, California, USA
Gastroenterol Nurs 29:305-8. 2006..This study suggests that a low-residue diet kit, given in conjunction with polyethylene glycol electrolyte or magnesium citrate and bisacodyl, produces adequate colon cleansing and patient tolerability...
- Residue-free sodium phosphate tablets (OsmoPrep) versus Visicol for colon cleansing: a randomized, investigator-blinded trialLawrence Wruble
Memphis Gastroenterology Group, Memphis, TN 38120, USA
Gastrointest Endosc 65:660-70. 2007..The bowel purgative Visicol contains microcrystalline cellulose (MCC) residue, which may impair full visibility during a colonoscopy. An MCC residue-free sodium phosphate (RF-NaP; OsmoPrep) tablet was developed...
- Bowel preparation for colonoscopy in very old patients: a randomized prospective trial comparing oral sodium phosphate and polyethylene glycol electrolyte lavage solutionL Seinelä
Services for Elderly People, City of Tampere, Tampere, Finland
Scand J Gastroenterol 38:216-20. 2003..Colonoscopic preparations are defectively tolerated among many very old patients and the quality of preparation is often inadequate...
- Is mechanical bowel preparation mandatory for elective colon surgery? A prospective randomized studyEdward Ram
Division of General Surgery, Rabin Medical Center, Campus Golda, Petach Tikva Sackler Medical School, Tel Aviv University, Tel Aviv, Israel
Arch Surg 140:285-8. 2005..It was assumed that with the improvement in surgical technique together with the use of more effective prophylactic antibiotics, it was possible that MBP would no longer be necessary...
- Mechanical bowel preparation for elective colorectal surgery: a meta-analysisPascal Bucher
Clinic of Visceral and Transplantation Surgery, Department of Surgery and Division of Medical Statistics, Geneva University Hospital, Geneva, Switzerland
Arch Surg 139:1359-64; discussion 1365. 2004..There is little scientific evidence to support the routine practice of mechanical bowel preparation (MBP) before elective colorectal surgery in order to minimize the risk of postoperative septic complications...
- Renal failure due to acute phosphate nephropathyT M Slee
Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Neth J Med 66:438-41. 2008..It could even be argued that these drugs should not be prescribed at all...
- Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing: clinical patterns and renal biopsy findingsGulfiliz Gonlusen
Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, Texas, USA
Arch Pathol Lab Med 130:101-6. 2006..The renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The renal failure improved at least partially in most of these patients, but persisted in rare cases...
- Mechanical bowel preparation or not? Outcome of a multicenter, randomized trial in elective open colon surgeryPatrick Fa-Si-Oen
Department of Surgery, Maxima Medical Center, Veldhoven, The Netherlands
Dis Colon Rectum 48:1509-16. 2005..In recent literature the value of this procedure is under discussion. To verify the value of mechanical bowel preparation in elective open colon surgery, a randomized clinical trial was conducted...
- Myths and misconceptions about chronic constipationStefan A Müller-Lissner
Abteilung Innere Medizin, Park Klinik Weissensee, Schönstrasse 80, 13086 Berlin, Germany
Am J Gastroenterol 100:232-42. 2005..Tolerance to stimulant laxatives is uncommon. There is no indication for the occurrence of "rebound constipation" after stopping laxative intake. While laxatives may be misused, there is no potential for addiction...
- Renal failure following bowel cleansing with a sodium phosphate purgativeGlen S Markowitz
Nephrol Dial Transplant 20:850-1. 2005
- CT colonography: optimisation, diagnostic performance and patient acceptability of reduced-laxative regimens using barium-based faecal taggingStuart A Taylor
Department of Specialist Radiology, University College Hospital, Euston Road, London, UK
Eur Radiol 18:32-42. 2008..Reduced preparation was tolerated better than full endoscopic preparation by 61%. Reduced-laxative CTC with three doses of 20 ml 40% barium sulphate is as effective as more complex regimens, retaining adequate diagnostic accuracy...
- Oral sodium phosphate solution: a review of its use as a colorectal cleanserMonique P Curran
Adis International Limited, Auckland, New Zealand
Drugs 64:1697-714. 2004..Oral sodium phosphate solution had similar tolerability, but was considered to be more acceptable than commercially available oral sodium phosphate tablets prior to colonoscopy (data from one study)...
- Assessing attitudes toward laxative preparation in colorectal cancer screening and effects on future testing: potential receptivity to computed tomographic colonographyTimothy J Beebe
Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 82:666-71. 2007..The overall response rate was 49%. Analysis focused on the 759 respondents who were 50 years or older...
- Kidney biopsies taken before and after oral sodium phosphate bowel cleansingWilly Aasebø
Medical Department, Akershus University Hospital, NO 1478 Lørenskog, Norway
Nephrol Dial Transplant 22:920-2. 2007
- Acute phosphate nephropathy following oral sodium phosphate solution to cleanse the bowel for colonoscopyAnnette Beyea
Department of Internal Medicine, Section of Nephrology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
Am J Kidney Dis 50:151-4. 2007
- The use of mechanical bowel preparation in elective colorectal surgeryAlison S McCoubrey
Department of Surgery, Antrim Area Hospital, Antrim BT41 2RL, United Kingdom
Ulster Med J 76:127-30. 2007..A literature search was undertaken to ascertain the evidence available regarding the use of MBP in elective colorectal surgery...
- Risk of further decline in renal function after the use of oral sodium phosphate or polyethylene glycol in patients with a preexisting glomerular filtration rate below 60 ml/minStefan Russmann
The Degge Group, Arlington, Virginia 22209, USA
Am J Gastroenterol 103:2707-16. 2008....
- Noncathartic CT colonography with stool tagging: performance with and without electronic stool subtractionC Daniel Johnson
Department of Radiology, Mayo Clinic, 13400 E Shea Blve, Scottsdale, AZ 85259, USA
AJR Am J Roentgenol 190:361-6. 2008....
- Hyperphosphataemia after bowel preparation with oral sodium phosphateE J Ainley
Endoscopy 38:759. 2006
- Acute phosphate nephropathy after sodium phosphate preparationsAndrew Connor
Department of Renal Medicine, Dorset County Hospital, Dorchester DT1 2JY
BMJ 337:a182. 2008
- Case records of the Massachusetts General Hospital. Case 27-2008. A 64-year-old man with abdominal pain, nausea, and an elevated level of serum creatinineTheodore I Steinman
Renal Division, Beth Israel Deaconess Medical Center, Boston, USA
N Engl J Med 359:951-60. 2008
- An easily overlooked iatrogenic cause of renal failureN Demoulin
Department of Nephrology, Cliniques Universitaires St Luc, Université Catholique de Louvain Medical School, Brussels, Belgium
Clin Nephrol 70:176-7. 2008..The patient had residual renal impairment at 8-month follow-up. Greater awareness of this complication is needed amongst health care professionals. The preventive strategies are discussed...
- CT colonography after fecal tagging with a reduced cathartic cleansing and a reduced volume of bariumPhilippe Lefere
Department of Radiology, Stedelijk Ziekenhuis, Bruggesteenweg 90, Roeselare B-8800, Belgium
AJR Am J Roentgenol 184:1836-42. 2005..Another 8-mm lesion was missed. CONCLUSION: In the present study, CT colonography after fecal tagging with 50 mL of barium combined with a reduced cathartic cleansing was feasible...
- Effect of oral purgatives on gastric and small bowel transit time in capsule endoscopyZvi Fireman
Departments of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
Isr Med Assoc J 6:521-3. 2004....
- Management of opioid-induced constipationD M Thorpe
Pain Medicine and Palliative Care, The Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 2100, Salt Lake City, UT 84112, USA
Curr Pain Headache Rep 5:237-40. 2001....
- Trends in preparation for colorectal surgery: survey of the members of the American Society of Colon and Rectal SurgeonsOded Zmora
Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA
Am Surg 69:150-4. 2003..There is a trend toward the use of a shorter course of postoperative intravenous antibiotics and the use of sodium phosphate for mechanical cleansing...
- Colon and rectal surgery without mechanical bowel preparation: a randomized prospective trialOded Zmora
Department of Surgery, Sheba Medical Center and Sackler School of Medicine, Tel Aviv, Israel
Ann Surg 237:363-7. 2003..To assess whether elective colon and rectal surgery can be safely performed without preoperative mechanical bowel preparation...
- Assessing and managing opiate-induced constipation in adults with cancerSusan C McMillan
University of South Florida College of Nursing, Tampa, FL 33612, USA
Cancer Control 11:3-9. 2004
- Single blind, randomised trial of efficacy and acceptability of oral picolax versus self administered phosphate enema in bowel preparation for flexible sigmoidoscopy screeningW S Atkin
Imperial Cancer Research Fund Colorectal Cancer Unit, St Mark s Hospital, Northwick Park, Harrow HA1 3UJ
BMJ 320:1504-8; discussion 1509. 2000..To compare the acceptability and efficacy of two methods of self administered bowel preparation for flexible sigmoidoscopy screening: a single phosphate enema and a single sachet of Picolax...
- Optimizing bowel preparation for multidetector row CT colonography: effect of Citramag and PicolaxS A Taylor
Department of Intestinal Imaging, St Mark's Hospital, Northwick Park, London, UK
Clin Radiol 58:723-32. 2003..CONCLUSION: Picolax results in a significantly drier colon than Citramag and associated with more retained residue. We found Picolax the more suitable preparation for CT colonography...
- Is mechanical bowel preparation really necessary in colorectal surgery?Maqbool Ahmad
Department of Surgery, Combined Military Hospital, Pano Aqil Cantt
J Coll Physicians Surg Pak 13:637-9. 2003..To determine the outcome of colorectal surgery without mechanical bowel preparation...
- The effect of mechanical bowel preparation on human colonic tissue in elective open colon surgeryPatrick R Fa-Si-Oen
Dis Colon Rectum 47:948-9. 2004
- CT colonography without cathartic preparation: feasibility studyM R Callstrom
Department of Diagnostic Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Radiology 219:693-8. 2001..Sensitivity for polyp detection in patients with adequate stool labeling approaches the sensitivity for polyp detection in prepared colons...
- Incidence, prevalence, and management of opioid bowel dysfunctionM Pappagallo
New York University School of Medicine, Hospital for Joint Diseases, New York, New York 10003, USA
Am J Surg 182:11S-18S. 2001..With a better understanding of the prevalence of OBD and its pathophysiology, a more aggressive approach to preventing and treating OBD is possible and will likely improve the quality of life of patients with pain...
- Dietary fecal tagging as a cleansing method before CT colonography: initial results polyp detection and patient acceptancePhilippe A Lefere
Department of Radiology, Stedelijk Ziekenhuis, Bruggesteenweg 90, 8800 Roeselare, Belgium
Radiology 224:393-403. 2002..To compare reduced colonic cleansing based on dietary fecal tagging (FT) with standard (non-FT) colonic cleansing with regard to patient acceptance, sensitivity, and specificity...
- Right hemicolectomy: mechanical bowel preparation is not requiredJ O Jansen
Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, UK
J R Coll Surg Edinb 47:557-60. 2002..Two patients developed wound infections and one patient died with no autopsy evidence of anastomotic leak. CONCLUSION: Mechanical bowel preparation can safely be omitted prior to right hemicolectomy in patients with colonic cancer...
- Constipation: evaluation and managementM L Borum
Division of Gastroenterology, Department of Medicine, George Washington University Medical Center, Washington, DC 20037, USA
Prim Care 28:577-90, vi. 2001..Initial intervention should include dietary measures and fiber supplements; however, if fiber supplementation is ineffective, other agents can be used. Surgery should be reserved for patients who meet specific clinical criteria...
- Increased stool frequency occurs when finely processed pea hull fiber is added to usual foods consumed by elderly residents in long-term careWendy J Dahl
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
J Am Diet Assoc 103:1199-202. 2003..001). With treatment, prune-based laxative administration decreased (P<.001). Thus, addition of a moderate amount of finely processed fiber to foods results in increased bowel frequency in institutionalized elderly individuals...
- Differential therapy of constipation--a reviewR Wanitschke
I. Medizinische Klinik und Poliklinik, , Mainz, Germany
Int J Clin Pharmacol Ther 41:14-21. 2003..Laxative abuse due to chronic constipation is rare and almost always associated with psychosomatic-psychiatric disorders...
- A quality improvement project comparing two regimens of medication for colonoscopy preparationJane Allaire
National Naval Medical Center, Department of Gastroenterology, Bethesda, Maryland, USA
Gastroenterol Nurs 27:3-8. 2004....
- Randomized clinical trial of bowel preparation with a single phosphate enema or polyethylene glycol before elective colorectal surgeryC Platell
Colorectal Surgical Unit, Fremantle Hospital, Fremantle, Western Australia, Australia
Br J Surg 93:427-33. 2006..The aim of this clinical trial was to evaluate whether a single phosphate enema was as effective as oral polyethylene glycol (PEG) solution in preventing anastomotic leakage...
- Oral sodium phosphate (Fleet) is a superior colonoscopy preparation to Picopre (sodium picosulfate-based preparation)Joe J Tjandra
Department of Colorectal Surgery, Royal Melbourne and Melbourne Private Hospitals, Melbourne, Victoria, Australia
Dis Colon Rectum 49:616-20. 2006..This randomized, controlled trial was designed to compare oral sodium phosphate (Fleet) with Picoprep (sodium picosulfate-based preparation)...
- Treatment of severe and intractable constipationAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, MN 55905, USA
Rev Gastroenterol Mex 69:89-94. 2004
- Sodium phosphate is superior to polyethylene glycol in bowel cleansing and shortens the time it takes to visualize colon mucosaJ Kössi
Dept of Surgery, Paijat Hame Central Hospital, Lahti, Finland
Scand J Gastroenterol 38:1187-90. 2003..The aim of this study was to compare the bowel cleansing effect of NaP solution with that of PEG-EL solution and to evaluate whether the cleansing effect correlates with the time needed to perform colonoscopy...
- Efficacy and safety of bisacodyl in the acute treatment of constipation: a double-blind, randomized, placebo-controlled studyS Kienzle-Horn
Scratch Pharmaberatung, Butzbach, Germany
Aliment Pharmacol Ther 23:1479-88. 2006..Serum electrolyte levels and incidence of adverse events were comparable between treatment groups. CONCLUSIONS: Bisacodyl is effective and safe in improving stool frequency and consistency in acute treatment of idiopathic constipation...
- A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American GastrointestinalSteven D Wexner
Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA
Dis Colon Rectum 49:792-809. 2006
- Effects of a meal and bisacodyl on colonic motility in healthy volunteers and patients with slow-transit constipationA M P De Schryver
The Gastrointestinal Research Unit, Department of Gastroenterology and Surgery, University Medical Center Utrecht, The Netherlands
Dig Dis Sci 48:1206-12. 2003..005). In conclusion, this study shows that in patients with slow-transit constipation, the colonic motor response to a meal and to bisacodyl, as well as the perception of bisacodyl-induced propagated pressure waves is decreased...
- Evaluation and treatment of constipationSteven A Dosh
Department of Family Practice, Michigan State University, 3409 Ludington, Escanaba, MI 49829, USA
J Fam Pract 51:555-9. 2002
- Management principles of organic causes of childhood constipationNan Tobias
Cincinnati Children s Hospital, Division of Urology, 3333 Burnet Ave, MLC 5037, Cincinnati, Ohio 45229, USA
J Pediatr Health Care 22:12-23. 2008..Children and adolescents who experience bowel dysfunction require patience and sensitive support from their health care providers so that they can live productive and emotionally healthy lives...
- Nutritional options for infant constipationSilvia Salvatore
Nutrition 23:615-6. 2007
- Risks of oral sodium phosphate for precolonoscopy bowel preparation in childrenEric Hassall
Gastrointest Endosc 65:1102-4; author reply 1104-5. 2007
- Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparationsSherman M Chamberlain
Section of Gastroenterology, Medical College of Georgia, 1120 15th Street BBR 2538, Augusta, Georgia 30912, USA
Dig Dis Sci 52:3165-8. 2007..Aspartame or its constituent amino acids may enhance phosphate absorption across the human small intestine...
- Purging the colon while preserving the kidneysHemant K Roy
Arch Intern Med 168:565-7. 2008
- When the going gets tough: pediatric constipation and encopresisLisa Philichi
Gastroenterology Clinic, Mary Bridge Children s Hospital and Health Center, 311 South L St, MS 311 W3 GI, Tacoma, WA 98405, USA
Gastroenterol Nurs 31:121-30. 2008..To successfully treat these disorders, a combination of family education, disimpaction and maintenance medications, a well-balanced diet, and behavior management is essential...
- Systematic review: oral bowel preparation for colonoscopyJ Belsey
JB Medical Ltd, The Old Brickworks, Little Cornard, Sudbury, UK
Aliment Pharmacol Ther 25:373-84. 2007..There are many published trials of colon cleansing regimens for colonoscopy but no clear consensus regarding relative performance...
- Comparison of standard polyethylene glycol and two doses of oral sodium phosphate solution in precolonoscopy bowel preparation: a randomized controlled trialM Picchio
Department of Surgery, Civil Hospital A Fiorini, Latina, Italy
Acta Gastroenterol Belg 71:15-20. 2008..This study was undertaken to compare the efficacy, side effects and patient acceptance of standard 4-liters polyethylene glycol (PEG) and 2 doses of sodium phosphate (NaP) solution for precolonoscopy colon cleansing...
- Clinical trial: sodium phosphate tablets are preferred and better tolerated by patients compared to polyethylene glycol solution plus bisacodyl tablets for bowel preparationG R Lichtenstein
University of Pennsylvania, Gastroenterology Division, Philadelphia, PA 19104 4283, USA
Aliment Pharmacol Ther 26:1361-70. 2007..Aim To compare patient acceptance, preference and tolerability of 32-sodium phosphate tablets vs. 2L polyethylene glycol solution plus 4 bisacodyl tablets for bowel preparation...
- Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trialHsiao Ling Chen
Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan 402
J Am Coll Nutr 27:102-8. 2008..In addition, the mechanisms by which KGM modulated the bowel habit were explored...
- Is blinding the endoscopists to bowel preparations in randomized-controlled trials a reality?Samer El-Dika
Department of Medicine, Veterans Affairs Medical Center, Salem, VA 24153, USA
Cancer Detect Prev 30:552-9. 2006..The primary aim of this study was to explore whether endoscopists can be effectively blinded to the type of bowel preparation...
- Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and encopresis in childrenD S Pashankar
Division of Gastroenterology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA
J Pediatr 139:428-32. 2001..0 +/- 2.4 to 1.3 +/- 0.7 (P =.003). The mean effective dose was 0.84 g/kg/d (range, 0.27-1.42 g/kg/d). CONCLUSION: Daily administration of PEG at a mean dose of 0.8 g/kg is an effective, safe, and palatable treatment for constipation...
- Constipation: evaluation and treatmentSatish S C Rao
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Gastroenterol Clin North Am 32:659-83. 2003..In the near future, user-friendly biofeedback programs including home therapy may facilitate wider use of these methods for patients with dyssynergic defecation...
- [Constipation in patients with diabetes mellitus]Siegbert Rossol
Medizinische Klinik, Krankenhaus Nordwest, Frankfurt am Main
MMW Fortschr Med 149:39-42. 2007..Slow transit constipation, which is typically observed in diabetics, can be best controlled with polyethylene glycol, bisacodyl or sodium picosulphate...
- [Electrolyte disorders following colonic cleansing for imaging studies]Mar Gutiérrez-Santiago
Servicio de Medicina Interna, Hospital Universitario Marques de Valdecilla, Universidad de Cantabria, Santander, Cantabria, Spain
Med Clin (Barc) 126:161-4. 2006..An adequate bowel cleansing is needed prior to radiologic and endoscopic procedures. However, it may have a number of adverse effects, including abnormalities of calcium-phosphorus homeostasis...
- Polyethylene glycol for constipation in children younger than eighteen months oldSonia Michail
Wright State University School of Medicine and The Children s Medical Center, Dayton, Ohio 45404, USA
J Pediatr Gastroenterol Nutr 39:197-9. 2004..Data on its safety and efficacy in infants are lacking. The goal of this study was to determine safety, efficacy, and optimal dose of polyethylene glycol powder for treatment of constipation in patients younger than 18 months...
- Double-blind randomized evaluation of clinical and biological tolerance of polyethylene glycol 4000 versus lactulose in constipated childrenChristophe Dupont
Hopital Saint Vincent de Paul, Service de Neonatologie, Paris, France
J Pediatr Gastroenterol Nutr 41:625-33. 2005..To assess the safety of a polyethylene glycol (PEG) 4000 laxative without additional salts in pediatric patients...
- Evaluation of polyethylene glycol plus electrolytes in the treatment of severe constipation and faecal impaction in adultsChun-Chia Chen
Taipei Veteran's General Hospital, Taipei 111, Taiwan
Curr Med Res Opin 21:1595-602. 2005..CONCLUSION: PEG+E, administered orally at a dose equivalent to eight 13.8 g sachets (1 L) per day over three days, was a highly effective and well tolerated therapy for the treatment of severe constipation and faecal impaction...
- Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipationI L Khalif
State Scientific Center for Coloproctology, Moscow, Russia
Dig Liver Dis 37:838-49. 2005..Relief of constipation tends to normalise these findings suggesting that these changes are secondary to, rather than a cause of, constipation...
- Recognizing the clinical contraindications to the use of oral sodium phosphate for colon cleansing: a case studyLawrence C Hookey
Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Hotel Dieu Hospital, Queen's University, Kingston, Ontario, Canada
Can J Gastroenterol 18:455-8. 2004..Recommendations for relative and absolute contraindications to the use of oral sodium phosphate are described...
- Pharmacologic treatment of constipation in cancer patientsJorge G Avila
Department of Pharmacy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Control 11:10-8. 2004
- Efficacy of bowel preparation with the use of a prepackaged, low fibre diet with a low sodium, magnesium citrate cathartic vs. a clear liquid diet with a standard sodium phosphate catharticM DeLegge
Digestive Disease Center, Division of Gastroenterology and Hepatology, Medical University of South Carolina MUSC, SC, USA
Aliment Pharmacol Ther 21:1491-5. 2005..A colon free of faecal residue is required for accurate diagnostic colonoscopy. Patient tolerance of his/her colonoscopy cathartic regimen affects patient compliance and willingness to undergo repeated examinations...
- Management of constipation in residents with dementia: sorbitol effectiveness and costLadislav Volicer
Geriatrics Research Education Clinical Center, E N Rogers Memorial Veterans Hospital, Bedford, and Boston University School of Medicine, Department of Pharmacology, MA, USA
J Am Med Dir Assoc 5:239-41. 2004..The objective of this report is to describe a cost-effective strategy for management of constipation in nursing home residents with dementia...
- Preventing constipation in older adultsKristen L Mauk
Valparaiso University, Valparaiso, IN, USA
Nursing 35:22-3. 2005
- Effects of lactulose and polyethylene glycol on colonic transitE Fritz
Aliment Pharmacol Ther 21:259-68. 2005..95, P < 0.001). CONCLUSION: Lactulose accelerates colonic transit. However, compared with polyethylene glycol, transit during lactulose is prolonged...
- Argon plasma coagulation in the treatment of hemorrhagic radiation proctitis is efficient but requires a perfect colonic cleansing to be safeE Ben-Soussan
Department of Gastroenterology, Rouen University Hospital Charles Nicolle, Rouen, France
Eur J Gastroenterol Hepatol 16:1315-8. 2004..We evaluate prospectively effectiveness, tolerance, predictive factors of failure and complications of argon plasma coagulation (APC) in the treatment of hemorrhagic radiation proctitis (HRP)...
- PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trialW Voskuijl
Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
Gut 53:1590-4. 2004..However, no large randomised controlled trials exist evaluating the efficacy of either laxative...
- DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATIONALAN HOFMANN; Fiscal Year: 2005..indicates that endogenous C24 dihydroxy- bile acids (chenodeoxycholic and/or deoxycholic acid) act as natural cathartics by inducing colonic secretion and colonic propulsion...
- Novel Treatment Strategies for Constipation and Role of Brain-Gut axisSatish Rao; Fiscal Year: 2009..These studies aim to define the mechanisms of, and evaluate new therapies for dyssynergia, rectal hyposensitivity and rectal hypersensitivity, and could significantly impact constipation treatments. ..
- Novel Treatment Strategies for Constipation and Role of Brain-Gut axisSatish Rao; Fiscal Year: 2007..These studies aim to define the mechanisms of, and evaluate new therapies for dyssynergia, rectal hyposensitivity and rectal hypersensitivity, and could significantly impact constipation treatments. ..
- Novel Treatment Strategies for Constipation and Role of Brain-Gut axisSATISH SC RAO; Fiscal Year: 2010..These studies aim to define the mechanisms of, and evaluate new therapies for dyssynergia, rectal hyposensitivity and rectal hypersensitivity, and could significantly impact constipation treatments. ..
- NEUROMUSCULAR CONDITION THERAPY-DYSSYNERGIC DEFECATIONSatish Rao; Fiscal Year: 2004..abstract_text> ..
- 5-Year Survival Following Injury in Geriatric PatientsLaura Criddle; Fiscal Year: 2006..Contribution: This foundational study will provide basic information about the survival patterns of injured elders as a basis for the development of interventions to improve geriatric survival. ..
- Pharmacogenomics of Gastric Function & Weight in ObesityMICHAEL L CAMILLERI; Fiscal Year: 2010....
- Antidepressant Therapy for Functional DyspepsiaNicholas Talley; Fiscal Year: 2007..abstract_text> ..
- Outcome of Adolescent-Onset Eating DisordersAnna Bardone Cone; Fiscal Year: 2006....
- ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROMEMichael Camilleri; Fiscal Year: 2007..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
- Training Program in Gastrointestinal EpidemiologyPhilip Schoenfeld; Fiscal Year: 2007..To capitalize on this rich environment, trainees will have 80% of their time protected to participate in the formal coursework, interactive seminar series, and mentorship from a team of research preceptors. ..
- Bupropion SR as an Anti-Craving Anti-Obesity AgentKristine Steffen; Fiscal Year: 2007..Longer term implications for the results of this study include the potential investigation of this agent as a therapeutic intervention for conditions such as obesity and binge eating disorder. ..
- Pathophysiology of Anorectal DisordersAdil E Bharucha; Fiscal Year: 2010..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMichael Camilleri; Fiscal Year: 2009..The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- Pathophysiology of Anorectal DisordersAdil Bharucha; Fiscal Year: 2009..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
- Antidepressant Therapy for Functional DyspepsiaNicholas Talley; Fiscal Year: 2007..at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Pharmacogenomics of Gastric Function & Weight in ObesityMichael Camilleri; Fiscal Year: 2007..It will also identify physiological and genetic factors that predict therapeutic success in the treatment of obesity with sibutramine. ..
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- Colon Polyp Screening with Colonoscopy in WomenPhilip Schoenfeld; Fiscal Year: 2005..Ultimately, the proposed research studies, didactic coursework, and mentoring hopefully will lead to successful R01 applications. ..
- Epidemiology and Mechanisms of Fecal IncontinenceAdil Bharucha; Fiscal Year: 2005..abstract_text> ..
- ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCERSara Olson; Fiscal Year: 2005..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
- Colon Polyp Surveillance with DNA Analysis of StoolPhilip Schoenfeld; Fiscal Year: 2002..colonoscopy as a surveillance tool. Ultimately, this trial will produce pilot data to determine if a randomized controlled trial of fecal MTAP vs. colonoscopy for colon adenoma surveillance should be performed...
- ALPHA 2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2001....
- ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDERAdil Bharucha; Fiscal Year: 2002..abstract_text> ..
- Opioid Receptor Imaging by PET in Bulimia NervosaANGELA GUARDA; Fiscal Year: 2005..abstract_text> ..
- PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEMROBERT DE LISLE; Fiscal Year: 2003..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
- TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTIONROBERT DE LISLE; Fiscal Year: 2003..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..