psychotropic drugs

Summary

Summary: A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).

Top Publications

  1. ncbi Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    Felicien Karege
    Geneva University Hospitals, Department of Psychiatry, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Mol Brain Res 136:29-37. 2005
  2. ncbi The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
    Y K Kim
    Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Korea
    Mol Psychiatry 7:1107-14. 2002
  3. doi Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
    Ivan J Torres
    Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
    J Clin Psychiatry 71:1234-42. 2010
  4. pmc Biomarkers in development of psychotropic drugs
    K Wiedemann
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    Dialogues Clin Neurosci 13:225-34. 2011
  5. pmc Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling
    A Einarson
    Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, 555 University Ave, Toronto ON 5G 1X8
    J Psychiatry Neurosci 26:44-8. 2001
  6. pmc Psychotropic medication use among nursing home residents in Austria: a cross-sectional study
    Eva Mann
    General practice and Institute for Health Services Research, Rankweil, Austria
    BMC Geriatr 9:18. 2009
  7. ncbi Mental disorders and the use of alternative medicine: results from a national survey
    J Unutzer
    UCLA Neuropsychiatric Institute, Santa Monica, CA 90024, USA
    Am J Psychiatry 157:1851-7. 2000
  8. ncbi Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol
    A A Boucher
    Neuroscience Institute of Schizophrenia and Allied Disorders, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia
    Psychopharmacology (Berl) 192:325-36. 2007
  9. pmc Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS Biol 5:e269. 2007
  10. doi Akt/GSK3 signaling in the action of psychotropic drugs
    Jean Martin Beaulieu
    Department of Anatomy and Physiology, Université Laval CRULRG, Quebec, Canada
    Annu Rev Pharmacol Toxicol 49:327-47. 2009

Research Grants

  1. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    Solomon H Snyder; Fiscal Year: 2010
  2. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2010
  3. EFFECT OF MARIJUANA ON MACROPHAGE ANTIGEN PRESENTATION
    Guy Cabral; Fiscal Year: 1993
  4. Immune Tolerance; Sigma Receptor as a Therapeutic Target
    Vadivel Ganapathy; Fiscal Year: 2003
  5. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1993
  6. AFFINITY LABELS FOR INOSITOL POLYPHOSPHATE RECEPTORS
    Glenn Prestwich; Fiscal Year: 1999
  7. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2007
  8. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2009
  9. Trafficking and Regulation of Monoamine Transporters
    Haley E Melikian; Fiscal Year: 2010
  10. PET IMAGING OF SEROTONIN TRANSPORTERS IN THE BRAIN
    Hank F Kung; Fiscal Year: 2010

Detail Information

Publications323 found, 100 shown here

  1. ncbi Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    Felicien Karege
    Geneva University Hospitals, Department of Psychiatry, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Mol Brain Res 136:29-37. 2005
    ..absence of change in BDNF and NT-3 levels of drug-treated suicide victims suggests that both neurotrophins are mediators of psychotropic drugs. A better understanding of the neurobiology of suicide could help detect populations at risk.
  2. ncbi The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
    Y K Kim
    Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Korea
    Mol Psychiatry 7:1107-14. 2002
    ....
  3. doi Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
    Ivan J Torres
    Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
    J Clin Psychiatry 71:1234-42. 2010
    ..The purpose of this study was to determine whether neuropsychological impairments are present in clinically stable patients with bipolar disorder shortly after resolution of their first manic episode...
  4. pmc Biomarkers in development of psychotropic drugs
    K Wiedemann
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    Dialogues Clin Neurosci 13:225-34. 2011
    ..With a view to developing more individually tailored therapeutic strategies, the characterization of patients and the courses of different types of treatment will become even more important in the future...
  5. pmc Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling
    A Einarson
    Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, 555 University Ave, Toronto ON 5G 1X8
    J Psychiatry Neurosci 26:44-8. 2001
    ..To assess the consequences to mother and baby of abruptly discontinuing antidepressant or benzodiazepine medication during pregnancy and to assess the impact of our counselling...
  6. pmc Psychotropic medication use among nursing home residents in Austria: a cross-sectional study
    Eva Mann
    General practice and Institute for Health Services Research, Rankweil, Austria
    BMC Geriatr 9:18. 2009
    ..In Austria, prevalence data are lacking. We aimed to determine the prevalence of psychotropic medication prescription in Austrian nursing homes and to explore characteristics associated with their prescription...
  7. ncbi Mental disorders and the use of alternative medicine: results from a national survey
    J Unutzer
    UCLA Neuropsychiatric Institute, Santa Monica, CA 90024, USA
    Am J Psychiatry 157:1851-7. 2000
    ..The study examined the relationship between mental disorders and the use of complementary and alternative medicine...
  8. ncbi Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol
    A A Boucher
    Neuroscience Institute of Schizophrenia and Allied Disorders, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia
    Psychopharmacology (Berl) 192:325-36. 2007
    ..Cannabis use may precipitate schizophrenia especially if the individual has a genetic vulnerability to this mental disorder. Human and animal research indicates that neuregulin 1 (Nrg1) is a susceptibility gene for schizophrenia...
  9. pmc Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS Biol 5:e269. 2007
    ....
  10. doi Akt/GSK3 signaling in the action of psychotropic drugs
    Jean Martin Beaulieu
    Department of Anatomy and Physiology, Université Laval CRULRG, Quebec, Canada
    Annu Rev Pharmacol Toxicol 49:327-47. 2009
    b>Psychotropic drugs acting on monoamine neurotransmission are major pharmacological treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar disorder, Tourette syndrome, ADHD, and Alzheimer disease...
  11. pmc Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders
    D F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    Transl Psychiatry 2:e110. 2012
    ....
  12. doi [Pharmacological neuroenhancement and brain doping : Chances and risks]
    A G Franke
    Klinik fur Psychiatrie und Psychotherapie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:853-9. 2010
    ..Brain doping" raises numerous ethical and social concerns that require a continued discussion. Demands of liberalization should be critically questioned...
  13. pmc The consumption of khat and other drugs in Somali combatants: a cross-sectional study
    Michael Odenwald
    PLoS Med 4:e341. 2007
    ....
  14. doi The risk of falls and fractures associated with persistent use of psychotropic medications in elderly people
    Agnes I Vitry
    Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, University of South Australia, GPO Box 2471, Adelaide SA 5001, Australia
    Arch Gerontol Geriatr 50:e1-4. 2010
    ..After adjusting for BMI, the IRR in females decreased to 1.22 (95% CI 1.02-1.45; p<0.015) for falls and the RR decreased to 1.92 (p<0.015, CI 1.13-3.24) for fractures...
  15. pmc Effect of interventions to reduce potentially inappropriate use of drugs in nursing homes: a systematic review of randomised controlled trials
    Louise Forsetlund
    Norwegian Knowledge Centre for the Health Services, St Olavsplass, Oslo, Norway
    BMC Geriatr 11:16. 2011
    ..The purpose of the review was to identify and summarise the effect of interventions aimed at reducing potentially inappropriate use or prescribing of drugs in nursing homes...
  16. doi Poor health behaviour and reduced quality of life of people treated with psychotropic drugs
    Martin Kopp
    Department of Sport Science, University of Innsbruck, Innsbruck, Austria
    Hum Psychopharmacol 26:161-7. 2011
    ..We have investigated health behaviour, quality of life, and sociodemographic variables of people with psychopharmacological treatment using data from the most recent Austrian Health Survey...
  17. doi Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Br J Psychiatry 200:97-106. 2012
    ..The efficacy of psychopharmacological treatments has been called into question. Psychiatrists are unfamiliar with the effectiveness of common medical drugs...
  18. ncbi Antisuicide properties of psychotropic drugs: a critical review
    Carrie L Ernst
    Department of Psychiatry, Cambridge Hospital, Cambridge, MA, USA
    Harv Rev Psychiatry 12:14-41. 2004
    ..Recommendations are provided to guide future research as well as clinical practice...
  19. doi Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis
    Frederic Bloch
    Department of Gerontology, Assistance Publique Hôpitaux de Paris Hôpital Broca, France
    J Aging Health 23:329-46. 2011
    To carry out meta-analyses on psychotropic drugs and to provide an update of the risk of falling in the elderly people related to psychotropic drugs.
  20. doi Neurodevelopmental effects of prenatal exposure to psychotropic medications
    Salvatore Gentile
    Department of Mental Health, ASL Salerno, Mental Health Center, Cava de Tirreni, Salerno, Italy
    Depress Anxiety 27:675-86. 2010
    ..For all classes of psychotropics, new and/or further studies are warranted to answer definitively the urgent question about the impact of prenatal exposure to such medications on infant development...
  21. ncbi Administrative initiatives for reducing inappropriate prescribing of psychotropic drugs in nursing homes: how successful have they been?
    Carmel M Hughes
    School of Pharmacy, Queen s University Belfast, Belfast, Northern Ireland
    Drugs Aging 22:339-51. 2005
    ..Exemplars of innovative prescribing models, involving pharmacists and encouraging resident-centred care, may offer a more palatable approach to improving drug use in this vulnerable population...
  22. ncbi Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 62:687-93. 2007
    ..The five-choice serial reaction time task (5CSRTT) is one such model. Here, we characterized the effects of four standard psychotropic agents on performance in the 5CSRTT...
  23. ncbi Exposure to potentially inappropriate drugs and drug-drug interactions in elderly nursing home residents in Helsinki, Finland: a cross-sectional study
    Helka M V Hosia-Randell
    Research and Development Unit for Medical Education, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Drugs Aging 25:683-92. 2008
    ....
  24. ncbi Regulation of adult neurogenesis by psychotropic drugs and stress
    R S Duman
    Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Hew Haven 06508, USA
    J Pharmacol Exp Ther 299:401-7. 2001
    ..In addition, exposure to psychotropic drugs or stress regulates the rate of neurogenesis in adult brain, suggesting a possible role for neurogenesis in ..
  25. ncbi Differential effects of psychotropic drugs on feeding in rats: is histamine blockade involved?
    N Orthen-Gambill
    Tufts University, Medford, MA 02155
    Pharmacol Biochem Behav 36:837-41. 1990
    ..In support of the hypothesis, significant appetite stimulation occurred only with promazine, while the other two test agents did not increase feeding, and even produced some suppression in food intake...
  26. ncbi Psychotropic drugs, cardiac arrhythmia, and sudden death
    Harry J Witchel
    Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Clin Psychopharmacol 23:58-77. 2003
    ..Some psychotropic drugs, particularly tricyclic antidepressants (TCAs) and antipsychotic agents, are correlated with iatrogenic ..
  27. ncbi Brain imaging research: does the science serve clinical practice?
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0807, USA
    Int Rev Psychiatry 19:541-58. 2007
    ..For example, an optimal dose of D2 antagonist antipsychotics produces occupancy of 65% to 80% of D2 receptors, while a greater dose carries a risk of extrapyramidal side effects...
  28. pmc Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells
    Audun O Vik-Mo
    Department of Clinical Medicine, University of Bergen, Dr Einar Martens Research Group for Biological Psychiatry and Bergen Mental Health Research Center, Norway
    BMC Pharmacol 9:10. 2009
    ..The aim of the present proof-of-principle study was to investigate whether such drugs also affect lipid transport and export pathways in cultured human CNS and liver cells...
  29. doi Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs
    Joanna M Wieronska
    Institute of Pharmacology PAS, Cracow, Poland
    Neurochem Int 55:85-97. 2009
    ..At present, the most potent seem to be negative allosteric modulators of the first group (mGlu1 and mGlu5), and positive allosteric modulators of the second (mGlu2 and mGlu3) and third (mGlu4/7/8) group of mGlu receptors...
  30. ncbi Behavioral symptoms and the administration of psychotropic drugs to aged patients with dementia in nursing homes and in acute geriatric wards
    K H Pitkala
    Department of Medicine, Geriatric Clinic, Helsinki University Hospital, Finland
    Int Psychogeriatr 16:61-74. 2004
    ..To describe the prevalence of various psychiatric and behavioral symptoms among patients with dementia in nursing homes and acute geriatric wards and to investigate the administration of psychotropic medications to these patients...
  31. doi Psychotropic drugs associated with corrected QT interval prolongation
    Charlotte van Noord
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Psychopharmacol 29:9-15. 2009
    To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a ..
  32. ncbi Psychopharmacological treatment of depression, anxiety, irritability and insomnia in patients receiving interferon-alpha: a prospective case series and a discussion of biological mechanisms
    Clementine Maddock
    Maudsley Hospital, London, UK
    J Psychopharmacol 18:41-6. 2004
    ..Thus, psychopharmacological management can successfully treat psychiatric symptoms in patients who are receiving IFN-alpha...
  33. ncbi A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs
    Kristian Linnet
    The Department of Forensic Chemistry, Institute of Forensic Medicine, University of Copenhagen, Frederik V s vej 11, 2100 Copenhagen, Denmark
    Eur Neuropsychopharmacol 18:157-69. 2008
    ..Moreover, the evidence for significant drug-drug interactions involving psychotropic drugs in rodents is considered...
  34. ncbi Functional dyspepsia: are psychosocial factors of relevance?
    Sandra Barry
    Department of Psychiatry, Alimentary Pharmacobiotic Centre, University College Cork, Cork, Ireland
    World J Gastroenterol 12:2701-7. 2006
    ..The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited...
  35. ncbi Use of psychotropic drugs in elderly nursing home residents with and without dementia in Helsinki, Finland
    Helka Hosia-Randell
    Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Drugs Aging 22:793-800. 2005
    ..Our objective was to describe the use of psychotropic drugs in all long-term nursing home residents > or =65 years of age with and without dementia in Helsinki, Finland.
  36. pmc Mental health policy and psychotropic drugs
    Richard G Frank
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Milbank Q 83:271-98. 2005
    The pace of innovation in psychotropic drugs has been rapid over the past 15 years. There also have been unprecedented increases in spending on prescription drugs generally and psychotropic medications specifically...
  37. doi Relation of prenatal smoking exposure and use of psychotropic medication up to young adulthood
    Mikael Ekblad
    Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Am J Epidemiol 174:681-90. 2011
    ..g., mothers' severe psychiatric illnesses). These findings show that exposure to smoking during pregnancy is linked to both mild and severe psychiatric morbidity...
  38. doi Psychotropic drugs on in vitro brain-derived neurotrophic factor production in whole blood cell cultures from healthy subjects
    Bun Hee Lee
    Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea
    J Clin Psychopharmacol 30:623-7. 2010
    ..Thus, the level of BDNF production in human blood cells may not influence the plasma or serum BDNF levels of subjects in clinical studies...
  39. ncbi The use of drug monotherapy in psychiatric inpatient treatment
    H Rittmannsberger
    Department of Psychiatry 1, Nerveuklinik, Wagner Jauregg, Liez, Austria
    Prog Neuropsychopharmacol Biol Psychiatry 26:547-51. 2002
    ..Monotherapy has always been the goal in psychiatric drug treatment, but it does not seem to be very common in everyday practice...
  40. ncbi Patient satisfaction with psychotropic drugs: sensitivity to change and relationship to clinical status, quality-of-life, compliance and effectiveness of treatment. Results from a nation-wide 6-month prospective study
    Isabelle Gasquet
    National Institute of Health and Medical Research U669 Paris Sud Innovation Group in Adolescent Mental Health Methodology, Maison des Adolescents, Cochin Hospital, Paris, France
    Eur Psychiatry 21:531-8. 2006
    ..Elements of validation of PSP were also assessed...
  41. ncbi Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study
    Wim J Tamminga
    Pharma Bio Research Group BV, Science Park, NL 9471 GP Zuidlaren, The Netherlands
    Eur J Clin Pharmacol 59:57-64. 2003
    ..assess the influence of polymorphic drug metabolism as assessed by genotyping, on the on the utilisation of psychotropic drugs in hospitalised psychiatric patients...
  42. doi Pills that swallow policy: clinical ethnography of a Community Mental Health Program in northern India
    Sumeet Jain
    University College London
    Transcult Psychiatry 46:60-85. 2009
    ..An understanding of this process is critical for the development of training and policy that can more effectively address local mental health concerns in rural India...
  43. pmc Dementia management programme in a community setting and the use of psychotropic drugs in the elderly population
    Erik Jedenius
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Alzheimer Disease Research Centre, Stockholm, Sweden
    Scand J Prim Health Care 29:181-6. 2011
    ..The objective of the present study is to evaluate whether the dementia programme had a secondary effect on the use of psychotropic medication in the elderly population in general...
  44. pmc Psychotropic medication use mediates the relationship between mood and anxiety disorders and obesity: findings from a nationally representative sample
    Jasper A J Smits
    Department of Psychology Southern Methodist University, Dedman College P O Box 750442 Dallas, TX 75275, USA
    J Psychiatr Res 44:1010-6. 2010
    ..The study findings guide advances in the theoretical conceptualization of the mechanisms involved in mood/anxiety disorder-obesity relations. Clinical implications are discussed...
  45. doi Impact of psychotropic drugs on adult hippocampal neurogenesis
    Anna Kubesova
    3rd Faculty of Medicine, Prague, Czech Republic
    Neurosci Res 73:93-8. 2012
    This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety...
  46. doi Inappropriate prescribing in older residents of Australian care homes
    A C Stafford
    School of Pharmacy, University of Tasmania, Hobart, TAS, Australia
    J Clin Pharm Ther 36:33-44. 2011
    ..We aimed to determine the prevalence of inappropriate prescribing in residents of Tasmanian (Australia) residential care homes using Beers and McLeod criteria...
  47. doi The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs
    Parichehr Hassanzadeh
    Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Psychopharmacology (Berl) 215:129-41. 2011
    ..Studies on the regulation of nerve growth factor (NGF) levels by psychotropics are limited in scope and the mechanism(s) remain elusive which merit further elucidation...
  48. doi Psychotropic drugs and falling accidents among the elderly: a nested case control study in the whole population of Scania, Sweden
    B Modén
    Department of Clinical Sciences in Malmo, CRC, Malmo University Hospital, S 205 02 Malmo, Sweden
    J Epidemiol Community Health 64:440-6. 2010
    The objective of this study was to investigate the associations between medication with psychotropic drugs and falling accidents in the whole population aged 65 years and older in the county of Scania, Sweden.
  49. ncbi Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity
    Nathalie Dupin
    INSERM, U796, Pathophysiology of Psychiatric Disorders, University Paris Descartes, Faculty of Medecine Paris Descartes, Paris F 75014, France
    Neurotox Res 10:193-8. 2006
    ..We are presently investigating the involvement of signalling molecules in producing these plastic changes...
  50. pmc Psychotropic drugs and the risk of fractures in old age: a prospective population-based study
    Janne Nurminen
    Family Medicine, Institute of Clinical Medicine, University of Turku, Lemminkäisenkatu 1, Turku 20014, Finland
    BMC Public Health 10:396. 2010
    ..However, also controversial results exist. The aim was to describe associations between the use of a psychotropic drug, or the concomitant use of two or more of these drugs and the risk of fractures in a population aged 65 years or over...
  51. ncbi Hidden cardiac lesions and psychotropic drugs as a possible cause of sudden death in psychiatric patients: a report of 14 cases and review of the literature
    Dominique Frassati
    Centre Hospitalier Le Vinatier, Bron, France
    Can J Psychiatry 49:100-5. 2004
    To confirm the hypothesis that psychotropic drugs, especially neuroleptics, lithium, and antidepressants, are implicated as a cause of unexpected sudden death in psychiatric patients because of their cardiotoxicity, especially when hidden ..
  52. ncbi [Reversible cardiomyopathy induced by psychotropic drugs: case report and literature overview]
    B Cruchaudet
    Centre de cardiologie clinique et interventionnelle, Hopital du Bocage, CHU Dijon, 2, Boulevard Marechal De Lattre de Tassigny, 21034 Dijon, France
    Ann Cardiol Angeiol (Paris) 51:386-90. 2002
    A number of psychotropic drugs, including tricyclic antidepressants, phenothiazine and lithium, have a well demonstrated risk of cardiotoxicity...
  53. ncbi [Taking drugs in the working environment: a study in a sample of 2106 workers in the Toulouse metropolitan area]
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, EA 3696, Unité de Pharmacoépidémiology, IFR 126, Faculte de Medecine, Toulouse, France
    Therapie 59:615-23. 2004
    ..The aim of this study was to investigate the frequency and characteristics of "supportive" drug use and addictive behaviour in the working environment...
  54. pmc Psychotropic drug use among older people in general practice: discrepancies between opinion and practice
    Andrea Lasserre
    INSERM, U707, Paris, France UPMC Université Paris 6, UMR S707, Paris, France
    Br J Gen Pract 60:e156-62. 2010
    The use of psychotropic drugs has increased over recent years in France. GPs are the first prescribers, especially for older patients.
  55. ncbi Psychogenic nonepileptic seizures
    Taoufik M Alsaadi
    Department of Neurology, University of California, Davis, Medical Center, Sacramento, California 95817 2307, USA
    Am Fam Physician 72:849-56. 2005
    ..Treatment involves discontinuation of antiepileptic drugs in patients without concurrent epilepsy and referral for appropriate psychiatric care. More studies are needed to determine the best treatment modalities...
  56. ncbi Psychotropic drugs and the perioperative period: a proposal for a guideline in elective surgery
    Frits J Huyse
    Dept of General Internal Medicine, University Medical Center, Groningen, The Netherlands
    Psychosomatics 47:8-22. 2006
    Evidence-based guidelines for the perioperative management of psychotropic drugs are lacking. The level of evidence is low and is based on case reports, open trials, and non-systematic reviews...
  57. ncbi The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes
    Geir Selbaek
    Research Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway
    Int J Geriatr Psychiatry 22:843-9. 2007
    Psychiatric and behavioural symptoms in dementia are associated with a range of negative outcomes, including institutional placement and the widespread use of psychotropic drugs in spite of limited evidence for their efficacy.
  58. ncbi Do male and female adolescents differ in the effect of individual and family characteristics on their use of psychotropic drugs?
    Michele Baumann
    Integrative Research Unit Individual and Social Development, Faculty LSHASE, University of Luxembourg, Luxembourg, Luxembourg
    Eur J Pediatr 166:29-35. 2007
    ..Preventive measures should be taken to make adolescents and their parents more aware of the risks and to improve their living conditions...
  59. ncbi Use of psychotropic drugs in an urban adolescent population: the impact of health-related variables, lifestyle and sociodemographic factors--The Oslo Health Study 2000-2001
    Svetlana Skurtveit
    Division of Epidemiology, Norwegian Institute of Public Health, Nydalen, Oslo, Norway
    Pharmacoepidemiol Drug Saf 14:277-83. 2005
    The aims of the study were to examine use of psychotropic drugs among 15-16 years old adolescents and to study the association between use of drugs and health-related, lifestyle and sociodemographic factors.
  60. pmc Duration of lithium treatment is a risk factor for reduced glomerular function: a cross-sectional study
    Alberto Bocchetta
    Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Via Ospedale 54, Cagliari, 09124 Italy
    BMC Med 11:33. 2013
    ..In this cross-sectional study, we examined glomerular function in a cohort of patients treated with lithium for up to 33 years and a control group of lithium-naïve patients treated with other mood-stabilizers...
  61. doi Analyses of second-generation 'legal highs' in the UK: initial findings
    Simon D Brandt
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Drug Test Anal 2:377-82. 2010
    ..These findings also suggest that both consumers and online sellers (unlike manufacturers and wholesalers) are, most likely unknowingly, confronted with the risk of criminalization and potential harm...
  62. doi Pollution by psychoactive pharmaceuticals in the Rivers of Madrid metropolitan area (Spain)
    Silvia González Alonso
    Department of Preventive Medicine, Public Health, Immunology, and Medical Microbiology, Faculty of Health Science, Rey Juan Carlos University, C Atenas s n, E 28922 Alcorcón, Madrid, Spain
    Environ Int 36:195-201. 2010
    ..We conclude that the origin of pharmaceutical pollution in the rivers of Madrid is mainly the discharge of sewage treatment plants in Madrid's metropolitan area and a comprehensive monitoring program should be implemented...
  63. ncbi Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs
    Edoardo Spina
    Institute of Pharmacology, University of Messina, Messina, Italy
    Epilepsia 43:37-44. 2002
    ..Conversely, new AEDs appear to have a lower potential for interactions with all psychotropic drugs. While antipsychotics and anxiolytics do not significantly influence the pharmacokinetics of most AEDs, some ..
  64. pmc QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes
    Katharina Wenzel-Seifert
    Klinische Pharmakologie, Klinik und Poliklinik fur Psychiatrie, Psychosomatik und Psychotherapie der Universität Regensburg, Universitätstr 84, 93053 Regensburg, Germany
    Dtsch Arztebl Int 108:687-93. 2011
    Many psychotropic drugs can delay cardiac repolarization and thereby prolong the rate-corrected QT interval (QTc)...
  65. doi Adverse endocrine and metabolic effects of psychotropic drugs: selective clinical review
    Chaya G Bhuvaneswar
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 2nd Floor, Outpatient Clinic of Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA
    CNS Drugs 23:1003-21. 2009
    ..They encourage continued critical assessment of benefits versus risks of psychotropic drugs and underscore the importance of close coordination of psychiatric and general medical care to improve long-..
  66. doi Mental distress and subsequent use of psychotropic drugs among adolescents-a prospective register linkage study
    Anne Kjersti Myhrene Steffenak
    Hedmark University College, Elverum, Norway
    J Adolesc Health 50:578-87. 2012
    To investigate the association between mental distress, other factors, and subsequent use of psychotropic drugs in adolescents aged 15-16 years.
  67. ncbi Prescribing potentially inappropriate psychotropic medications to the ambulatory elderly
    J R Mort
    College of Pharmacy South Dakota State University, 1011 11th St, Rapid City, SD 57701, USA
    Arch Intern Med 160:2825-31. 2000
    ..This study used the revised criteria in ambulatory settings to quantify potentially inappropriate prescription of psychotropic agents and identify associated characteristics...
  68. doi Clinically significant psychotropic drug-drug interactions in the primary care setting
    Brett A English
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Curr Psychiatry Rep 14:376-90. 2012
    ..Increased awareness of clinically relevant psychotropic drug interactions can aid clinicians to achieve optimal therapeutic outcomes in patients in the primary care setting...
  69. ncbi Pharmacokinetic properties of delta9-tetrahydrocannabinol in oral fluid of occasional and chronic users
    Stefan W Toennes
    Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 34:216-21. 2010
    ..5) with no difference between chronic and occasional users. The large inter- and intraindividual variability observed precludes a reliable estimation of THC serum concentrations from oral fluid data using this collection device...
  70. ncbi Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions
    Władysława A Daniel
    Polish Academy of Sciences, Institute of Pharmacology, 12 Smetna Street, 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 27:65-73. 2003
    ..Lysosomal trapping is an important mechanism of distribution of basic psychotropic drugs; however, the tissue distribution of the aliphatic-type phenothiazine neuroleptic promazine, tricyclic ..
  71. ncbi Perceived anxiety, depression, and sleeping problems in relation to psychotropic drug use among elderly in assisted-living facilities
    Ing Britt Holmquist
    Department of Nursing, Lund University, Sweden
    Eur J Clin Pharmacol 61:215-24. 2005
    ....
  72. pmc Organisational downsizing and increased use of psychotropic drugs among employees who remain in employment
    Mika Kivimaki
    Finnish Institute of Occupational Health, Helsinki, Finland
    J Epidemiol Community Health 61:154-8. 2007
    ..The authors examined whether working in downsizing organisations predicts use of psychotropic drugs among employees who remain in employment.
  73. ncbi Primary care services for depression in Harare, Zimbabwe
    Melanie Abas
    Sections of Old Age, Institute of Psychiatry, London
    Harv Rev Psychiatry 11:157-65. 2003
  74. ncbi Quality of life for people with dementia living in residential and nursing home care: the impact of performance on activities of daily living, behavioral and psychological symptoms, language skills, and psychotropic drugs
    C Ballard
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England, UK
    Int Psychogeriatr 13:93-106. 2001
    ..in six facilities received a standardized assessment (Neuropsychiatric Inventory [NPI], Barthel Scale, psychotropic drugs)...
  75. ncbi Prescribing psychoactive medications in nursing homes: current practice in Singapore
    K Mamun
    Division of Geriatric Medicine, Changi General Hospital CGH, 2 Simei Street 3, Singapore 529889
    Singapore Med J 44:625-9. 2003
    ..To assess the prescribing practice, use and potential adverse effects of psychoactive medications in Singapore nursing homes...
  76. ncbi The influence of psychotropic drugs and releasing hormones on anterior pituitary hormone secretion in healthy subjects and depressed patients
    G Laakmann
    Psychiatrische Klinik, , FRG
    Pharmacopsychiatry 23:18-26. 1990
    Pharmacoendocrinological studies have shown that psychotropic drugs with different actions have different effects on anterior pituitary hormone secretion in man...
  77. ncbi Rhabdomyolysis induced by psychotropic drugs
    Hayato Kaida
    Division of Nuclear Medicine, Department of Radiology, Kurume University School of Medicine, Kurume City, Japan
    Clin Nucl Med 30:569-70. 2005
    ..He had taken many psychotropic drugs as treatment for schizophrenia and was very dehydrated...
  78. ncbi Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome
    F Rouleau
    , Centre Hospitalier Universitaire d'Angers, France
    J Cardiovasc Electrophysiol 12:61-5. 2001
    b>Psychotropic Drugs and ST Segment Elevation. Transient ST segment elevation in right precordial leads with use of psychotropic drugs is reported in two cases of overdose and one case of therapeutic administration...
  79. ncbi Weight gain associated with psychotropic drugs
    P S Masand
    State University of New York Upstate Medical University, Department of Psychiatry, 750 E Adams Street, Syracuse, NY 13210, USA
    Expert Opin Pharmacother 1:377-89. 2000
    Weight gain is a common adverse effect of psychotropic drugs. Clinically significant weight gain puts the patient at risk for coronary heart disease, hypertension, Type II diabetes, dyslipidaemia and cancer, and can lead to non-compliance,..
  80. ncbi Psychotropic drugs in Bulgaria-frequency and risk of adverse drug reactions
    Z Dimitrova
    Department of Social Pharmacy, Faculty of Pharmacy, Medical University Sofia BG 1000, Sofia, 2 Dunav St, Bulgaria
    Boll Chim Farm 141:75-9. 2002
    ..to determine the frequency and risk of appearance of adverse drug reactions/ADRs/during the treatment with psychotropic drugs. The first part of the study is an analysis of the use of the psychotropic drugs for one-year period of time ..
  81. doi Cytochrome P450 2D6 genotyping: potential role in improving treatment outcomes in psychiatric disorders
    Julia Kirchheiner
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Ulm, Germany
    CNS Drugs 23:181-91. 2009
    ..However, routine application of pharmacogenetic dose adjustment in clinical practice requires prospective validation...
  82. doi Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia
    Renate M Nijk
    Center for Family Medicine, Geriatric Care and Public Health, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Int Psychogeriatr 21:485-93. 2009
    Neuropsychiatric symptoms in dementia patients are common and are often treated with psychotropic drugs. The aim of this study was to determine the prevalence and correlates of psychotropic drug use in Dutch nursing home patients with ..
  83. doi Let's get physical
    Timothy Wand
    Emergency Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Australia
    Int J Ment Health Nurs 17:363-9. 2008
    ..The authors argue that mental health nurses must play an active role in health promotion, primary prevention, and the early detection and management of physical health problems in all areas of clinical practice...
  84. ncbi Designer drugs in the general hospital
    Philip A Bialer
    Division of Consultation Liaison Psychiatry, Department of Psychiatry, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York, USA
    Psychiatr Clin North Am 25:231-43. 2002
    ..Finally, awareness of a severe withdrawal syndrome from GHB and its precursors is particularly important to psychiatrists of the medically ill, who may be called on to help in the management of these patients...
  85. ncbi Assay of Delta9-tetrahydrocannabinol (THC) in oral fluid-evaluation of the OraSure oral specimen collection device
    Gerold F Kauert
    Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 30:274-7. 2006
    ..1%. From these results it can be concluded that the OraSure OSCD is useful to collect oral fluid for reliable quantitative THC assay applying a modified elution procedure and gravimetric determination of the amount of oral fluid...
  86. ncbi [Ethical implications of placebo-controlled clinical trials for psychotropic drugs]
    H Helmchen
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Freie Universitat Berlin
    Nervenarzt 76:1319-29. 2005
    ..It is concluded that pure placebo-controlled clinical trials of new psychotropic drugs may be acceptable in minor psychic disorders, but in general -- at least in a pure form -- not in major ..
  87. ncbi Biomarkers in psychotropic drug development: integration of data across multiple domains
    Peter R Bieck
    Eli Lilly and Company, Neuroscience Therapeutic Area, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Annu Rev Pharmacol Toxicol 45:227-46. 2005
    ..Proteomic research using CSF will hopefully have a major impact on the development of treatments for psychiatric disorders...
  88. doi Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 258:21-7. 2008
    ..For psychoactive drugs, animal studies have shown that plasma concentrations of psychotropic drugs correlate well with concentrations in the target organ, the brain...
  89. ncbi Prevalence of psychotropic drug use in nursing homes for the aged in Quebec and in the French-speaking area of Switzerland
    Micheline Gobert
    Unité des Sciences Hospitalières HOSP, School of Public Health, Universite Catholique de Louvain, Brussels, Belgium
    Int J Geriatr Psychiatry 20:712-21. 2005
    The use of psychotropic drugs is high in institutionalised elderly, which raises the question of its appropriateness...
  90. doi [Chronic psychotropic drugs use in the Canadian labor force: what are the contributions of occupation and work organization conditions?]
    A Marchand
    Ecole de relations industrielles, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, H3C 3J7 Canada
    Rev Epidemiol Sante Publique 58:89-99. 2010
    This study aims to better understand the contributions of occupation and work organization conditions to the development of chronic psychotropic drugs use among workers in Canada.
  91. ncbi Pharmacological models in healthy volunteers: their use in the clinical development of psychotropic drugs
    Christian Gilles
    Centre Hospitalier De L ardenne, Sainte Ode, Belgium
    J Psychopharmacol 21:272-82. 2007
    ..Their use as industrial tools for drug evaluation requires specific, dedicated development...
  92. ncbi Why people do not take their psychotropic drugs as prescribed: results of the 2000 National Psychiatric Morbidity Survey
    C Cooper
    UCL, Department of Mental Health Sciences, London, UK
    Acta Psychiatr Scand 116:47-53. 2007
    ..We examined the prevalence and determinants of the reasons given for non-adherence to psychiatric medication in a representative community survey...
  93. ncbi The emerging role of pharmacogenetics: implications for clinical psychiatry
    Chee Hong Ng
    The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 38:483-9. 2004
    ..This article aims to review the implications of pharmacogenetics for clinical psychiatry; these are discussed in the context of environmental and sociocultural factors...
  94. ncbi Psychotropic drugs use and risk of heat-related hospitalisation
    Karin Martin-Latry
    Universite Victor Segalen Bordeaux 2, France
    Eur Psychiatry 22:335-8. 2007
    To assess if use of psychotropic drugs is associated with an increased risk of admission for heat-related pathologies during a heat wave period.
  95. ncbi A community based study of patterns of psychoactive substance use among street children in a local government area of Nigeria
    Jide Morakinyo
    Department of Psychiatry, University College Hospital, Oyo State, Ibadan, Nigeria
    Drug Alcohol Depend 71:109-16. 2003
    ..At present, there is insufficient information regarding the pattern of psychoactive substance use among this group of children in Nigeria...
  96. ncbi Cardiac effects of psychotropic drugs
    S A Chong
    Woodbridge Hospital and Institute of Mental Health, 10 Buangkok View, Singapore 539747
    Ann Acad Med Singapore 30:625-31. 2001
    ..Sudden death has been associated with certain psychotropic drugs and the underlying cause(s) have been suggested to be some adverse cardiac complications...
  97. ncbi Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs
    Elisa Celano
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Italy
    Biol Psychiatry 53:442-9. 2003
    ....
  98. ncbi Effects of psychotropic drugs on seizure threshold
    Francesco Pisani
    Department of Neurosciences and of Psychiatric and Anaesthesiological Sciences, First Neurological Clinic, The University of Messina, Messina, Italy
    Drug Saf 25:91-110. 2002
    b>Psychotropic drugs, especially antidepressants and antipsychotics, may give rise to some concern in clinical practice because of their known ability to reduce seizure threshold and to provoke epileptic seizures...
  99. ncbi Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Semin Liver Dis 22:169-83. 2002
    ..Well-known causes of liver injury such as chlorpromazine, phenytoin, and methyldopa are not discussed...
  100. doi Restraint use among nursing home residents: cross-sectional study and prospective cohort study
    Gabriele Meyer
    Unit of Health Sciences and Education, University of Hamburg, Hamburg, Germany
    J Clin Nurs 18:981-90. 2009
    ....
  101. ncbi [Cognition on demand?--The wish for cognition-enhancing drugs in medicine]
    Matthis Synofzik
    Institute fur Ethik und Geschichte in der Medizin, Schleichstrabe 8, 72074 Tubingen, Germany
    Ethik Med 18:37-50. 2006
    ..These offers seem to meet the wishes and needs of people striving for enhancement of their mental capacities. How should medicine deal with these wishes? And, especially, what criteria might serve a physician's decision-making?..

Research Grants83

  1. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    Solomon H Snyder; Fiscal Year: 2010
    ..grant has supported our research on fundamental neurochemical mechanisms which may underlie the actions of psychotropic drugs. In recent years we have characterized novel neurotransmitters such as nitric oxide and D-serine, areas ..
  2. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2010
    ....
  3. EFFECT OF MARIJUANA ON MACROPHAGE ANTIGEN PRESENTATION
    Guy Cabral; Fiscal Year: 1993
    ..The effect of THC on the secretion of the co-stimulatory signal interleukin-1, requisite for replication of T-helper cells in addition to antigen receptor occupancy, will be established using C3H/HeJ mouse thymocyte proliferation...
  4. Immune Tolerance; Sigma Receptor as a Therapeutic Target
    Vadivel Ganapathy; Fiscal Year: 2003
    ....
  5. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1993
    ..In addition to providing new information about determinants of two licit forms of drug taking behavior which produce significant health risk, these studies will provide an improved understanding of the nature of the addictive process...
  6. AFFINITY LABELS FOR INOSITOL POLYPHOSPHATE RECEPTORS
    Glenn Prestwich; Fiscal Year: 1999
    ..The affinity reagents and the binding domain data obtained from these reagents will be important in defining the mechanisms of these ubiquitous and varied molecular switches. ..
  7. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2007
    ..We will also use cytokine injections of non-infected mothers to help identify cytokines that may mediate the effects of maternal viral infection. ..
  8. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2009
    ....
  9. Trafficking and Regulation of Monoamine Transporters
    Haley E Melikian; Fiscal Year: 2010
    ....
  10. PET IMAGING OF SEROTONIN TRANSPORTERS IN THE BRAIN
    Hank F Kung; Fiscal Year: 2010
    ..The proposed tracers for imaging SERT can be prepared by regional radiopharmacies and distributed within any major metropolitan area benefiting a large number of patients undergoing antidepressant treatment. ..
  11. PROBLEM DRINKING IN WOMEN--A 20-YEAR NATIONAL STUDY
    Sharon Wilsnack; Fiscal Year: 2005
    ....
  12. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2001
    ..Collectively, these studies will provide fundamentally new information on the in vivo pharmacology of GABAA modulators and will help to identify the pharmacologic and behavioral determinants of physical dependence on sedative hypnotics. ..
  13. Periadolescent Methylphenidate exposure: Brain function
    Diana Dow Edwards; Fiscal Year: 2005
    ..Through these studies, a comprehensive pre-clinical evaluation of the effects of chronic methylphenidate on learning, behavior, brain function and molecular patterns will be completed. ..
  14. NEUROPSYCHOPHARMACOLOGY OF ALTERED CONSCIOUSNESS
    Reese Jones; Fiscal Year: 2007
    ..The studies are multidisciplinary. They involve only human volunteers. The research will further understanding psychoactive drug use, health consequences and management. ..
  15. DRUGS, ALCOHOL AND DRIVING: PREVALENCE AND CRASH RISK
    M Perrine; Fiscal Year: 2003
    ....
  16. Chronic PCP Primate PFC Dopamine Deficit and Schizophrenia
    Robert Roth; Fiscal Year: 2009
    ....
  17. Impact of the Medicare Part D Benzodiazepine Exclusion on Managed Care Patients
    Susan Ettner; Fiscal Year: 2007
    ..especially if they are withdrawn abruptly from the medication or switched to less appropriate or efficacious psychotropic drugs. We examine the implications of the loss of BZD coverage resulting from the Medicare Part D exclusion using ..
  18. Pharmacogenetics in indolealkylamine metabolism and drug interactions
    Aiming Yu; Fiscal Year: 2007
    ....