phytogenic antineoplastic agents

Summary

Summary: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

Top Publications

  1. ncbi Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    William J Gradishar
    Northwestern University, Breast Oncology, Division of Hematology Oncology, Department of Medicine, Chicago, IL 60611, USA
    J Clin Oncol 23:7794-803. 2005
  2. ncbi Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
  3. ncbi Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    Francisco J Esteva
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:1800-8. 2002
  4. ncbi Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    Nasser Hanna
    Indiana University, 535 Barnhill Dr, Room 473, Indianapolis, IN 46202, USA
    J Clin Oncol 22:1589-97. 2004
  5. doi Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer
    Mary E R O'Brien
    Royal Marsden Hospital, London, United Kingdom
    J Thorac Oncol 3:728-34. 2008
  6. ncbi Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
    S S Bacus
    Quantitative Diagnostic Laboratories, Inc, Elmhurst, Illinois 60126, USA
    Oncogene 20:147-55. 2001
  7. ncbi Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    Sudhakar Chintharlapalli
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77843 4466, USA
    Cancer Res 67:2816-23. 2007
  8. ncbi Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules
    Malathi Hari
    Discovery Oncology, Wyeth, 401 North Middletown Road, Room 4709, Building 200, Pearl River, NY 10965, USA
    Mol Cancer Ther 5:270-8. 2006
  9. ncbi Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation
    Ramachandra K Reddy
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:20915-24. 2003
  10. ncbi Inhibition of cancer growth by resveratrol is related to its low bioavailability
    Miguel Asensi
    Departamento de Fisiologia, Universidad de Valencia, Valencia, Spain
    Free Radic Biol Med 33:387-98. 2002

Detail Information

Publications296 found, 100 shown here

  1. ncbi Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    William J Gradishar
    Northwestern University, Breast Oncology, Division of Hematology Oncology, Department of Medicine, Chicago, IL 60611, USA
    J Clin Oncol 23:7794-803. 2005
    ..This phase III study was performed to confirm preclinical studies demonstrating superior efficacy and reduced toxicity of ABI-007 compared with standard paclitaxel...
  2. ncbi Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
    ..Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression...
  3. ncbi Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    Francisco J Esteva
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:1800-8. 2002
    ..To evaluate the safety and efficacy of weekly docetaxel plus trastuzumab in women with HER-2-overexpressing metastatic breast cancer. Efficacy was correlated with serum HER-2 extracellular domain (ECD) levels...
  4. ncbi Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    Nasser Hanna
    Indiana University, 535 Barnhill Dr, Room 473, Indianapolis, IN 46202, USA
    J Clin Oncol 22:1589-97. 2004
    ..To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with chemotherapy...
  5. doi Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer
    Mary E R O'Brien
    Royal Marsden Hospital, London, United Kingdom
    J Thorac Oncol 3:728-34. 2008
    ..Paclitaxel poliglumex (PPX), a macromolecular polymer-drug conjugate of paclitaxel and poly-l-glutamic acid, may enhance the therapeutic index of paclitaxel...
  6. ncbi Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
    S S Bacus
    Quantitative Diagnostic Laboratories, Inc, Elmhurst, Illinois 60126, USA
    Oncogene 20:147-55. 2001
    ..However, p53 may serve as a survival factor in breast carcinoma cells treated with Taxol by blocking cells in G2/M phase of the cell cycle...
  7. ncbi Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    Sudhakar Chintharlapalli
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77843 4466, USA
    Cancer Res 67:2816-23. 2007
    ..Thus, betulinic acid acts as a novel anticancer agent through targeted degradation of Sp proteins that are highly overexpressed in tumors...
  8. ncbi Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules
    Malathi Hari
    Discovery Oncology, Wyeth, 401 North Middletown Road, Room 4709, Building 200, Pearl River, NY 10965, USA
    Mol Cancer Ther 5:270-8. 2006
    ..These results suggest that a mutation in tubulin might affect microtubule stability as well as drug binding and contribute to the observed resistance profile...
  9. ncbi Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation
    Ramachandra K Reddy
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:20915-24. 2003
    ..Lastly, a GRP78 mutant deleted of its ATP binding domain fails to bind procaspase-7 and loses its protective effect against etoposide-induced apoptosis...
  10. ncbi Inhibition of cancer growth by resveratrol is related to its low bioavailability
    Miguel Asensi
    Departamento de Fisiologia, Universidad de Valencia, Valencia, Spain
    Free Radic Biol Med 33:387-98. 2002
    ....
  11. ncbi A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol
    J Gusman
    Laboratoire de Pharmacognosie et Bromatologie CP205 4, Institut de Pharmacie, Universite Libre de Bruxelles, Campus Plaine, Boulevard du Triomphe, 1050 Brussels, Belgium
    Carcinogenesis 22:1111-7. 2001
    ..These include cyclooxygenase, nitric oxide synthase and cytochrome P450 inhibition, as well as cell cycle effects, apoptosis modulation and hormonal activity...
  12. pmc Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
    Timothy F Burns
    Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:5556-71. 2003
    ..Finally, these studies suggest that disruption of Snk/Plk2 may be of therapeutic value in sensitizing paclitaxel-resistant tumors...
  13. pmc Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells
    S Ranganathan
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Br J Cancer 77:562-6. 1998
    ....
  14. ncbi Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    Y Yukimune
    Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd, Yamaguchi, Japan
    Nat Biotechnol 14:1129-32. 1996
    ..These results suggest that these two regions of methyl jasmonate are important for promoting the production of paclitaxel and related taxanes in Taxus cell cultures...
  15. ncbi Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies
    David W Nyman
    Department of Pharmacology Toxicology, Division of Hematology Oncology, Arizona Cancer Center University of Arizona Health Sciences Center, Tucson, USA
    J Clin Oncol 23:7785-93. 2005
    ..This study determined the maximum-tolerated dose (MTD) of ABI-007 monotherapy administered weekly (three weekly doses, repeated every 4 weeks) and assessed the pharmacokinetics of paclitaxel administered as ABI-007...
  16. ncbi Resveratrol-induced autophagocytosis in ovarian cancer cells
    Anthony W Opipari
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 64:696-703. 2004
    ....
  17. ncbi Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1
    Ling Hua Meng
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cancer Res 64:9086-92. 2004
    ..Collectively, these results show that tetrandrine arrests cells in G(1) by convergent mechanisms, including down-regulation of E2F1 and up-regulation of p53/p21(Cip1)...
  18. ncbi Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes
    Xiaohua Gao
    Division of Hematology and Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    J Nutr 132:2076-81. 2002
    ..Thus, despite strong antiproliferative and proapoptotic activities of resveratrol against 32Dp210 cells in vitro, a potential antileukemia effect in vivo, if present, occurs only in a small fraction of mice...
  19. ncbi A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS
    L Mu
    Division of Bioengineering, The National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore
    J Control Release 86:33-48. 2003
    ..Nanoparticles of nanometer size with narrow distribution can be obtained. A drug encapsulation efficiency as high as 100% can be achieved and the release kinetics can be controlled...
  20. ncbi Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer
    C C Lee
    Department of Pharmacy, King s College London, London SE1 9NN, UK
    J Ethnopharmacol 100:237-43. 2005
    ..59 microM). The Malaysian Alpinia galanga showed weak activity compared with the Thai sample and this was shown to be due to the relatively high amounts of 1'-acetoxychavicol acetate present in the Thai sample...
  21. ncbi Natural products in anticancer therapy
    A B da Rocha
    Comprehensive Cancer Center, The Lutheran University of Brazil, Canoas, RS
    Curr Opin Pharmacol 1:364-9. 2001
    ..Other agents originating from marine sources are bryostatin-1, aplidine, dolastatin 10 and ET-743, which have recently entered phase I and II clinical trials...
  22. doi Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion
    Zih Rou Huang
    Pharmaceutics Laboratory, Chang Gung University, Taoyuan, Taiwan, China
    Acta Pharmacol Sin 29:1094-102. 2008
    ..The aim of this study was to develop and characterize lipid nanoparticles with different lipid cores which can circumvent these problems...
  23. ncbi Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    Federico Innocenti
    Department of Medicine, University of Chicago, 5841 S Maryland Ave, MC2115, Chicago, IL 60637, USA
    J Clin Oncol 22:1382-8. 2004
    ..UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38. This study prospectively evaluated the association between the prevalence of severe toxicity and UGT1A1 genetic variation...
  24. ncbi Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan
    Ron H J Mathijssen
    Department of Medical Oncology, Rotterdam Cancer Institute Daniel den Hoed Kliniek and University Hospital Rotterdam, PO Box 5201, Rotterdam, 3008 AE, The Netherlands
    Curr Cancer Drug Targets 2:103-23. 2002
    ....
  25. ncbi Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression
    L Tessitore
    Dipartimento di Scienze Chimiche Alimentari Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale Amedeo Avogadro, Vercelli, Italy
    Carcinogenesis 21:1619-22. 2000
    ..In conclusion, the results suggest a protective role of RV in colon carcinogenesis with a mechanism involving changes in bax and p21 expression...
  26. pmc The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death
    Isabelle Petit
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, Department of Genetic Medicine, Division of Hematology Oncology, Weill Cornell Medical College, New York, NY 10021, USA
    Blood 111:1951-61. 2008
    ..As such, CA4P provides for an effective means to treat refractory organ-infiltrating leukemias...
  27. ncbi Tetrandrine-induced cell cycle arrest and apoptosis in Hep G2 cells
    Po Lin Kuo
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Taiwan
    Life Sci 73:243-52. 2003
    ..Taken together, p53 and Fas/FasL apoptotic system possibly participated in the antiproliferative activity of tetrandrine in Hep G2 cells...
  28. ncbi Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis
    Ming Tan
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell 9:993-1004. 2002
    ..Expressing a nonphosphorylatable mutant of Cdc2 renders cells more sensitive to taxol-induced apoptosis. Thus, ErbB2 membrane RTK can confer resistance to taxol-induced apoptosis by directly phosphorylating Cdc2...
  29. ncbi Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel
    Pascal Seve
    Service de Medecine Interne, Hospices Civils de Lyon, France
    Mol Cancer Ther 4:2001-7. 2005
    ....
  30. doi Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Toxicol Appl Pharmacol 229:33-43. 2008
    ....
  31. ncbi Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093)
    I E L M Kuppens
    Department of Medical Oncology, Antoni van Leeuwenhoek Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Chemother Pharmacol 55:72-8. 2005
    ..Furthermore, the safety of combined treatment was determined and whether known functional genetic polymorphisms of the MDR1 gene could be associated with variability in docetaxel pharmacokinetics was also investigated...
  32. ncbi Mechanism of taxol-induced apoptosis in human SKOV3 ovarian carcinoma cells
    Hak Jun Ahn
    Department of Anesthesiology and Pain Management, College of Medicine, University of Ulsan, Seoul Asan Medical Center, Seoul, Korea
    J Cell Biochem 91:1043-52. 2004
    ..Taken together, these findings suggest that in SKOV3 cells, taxol induces caspase-independent AIF-dependent apoptosis...
  33. ncbi Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations
    A Zhang
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Pharmacogenomics J 7:333-8. 2007
    ..Our results indicate that heterogeneity among different ethnic populations is possibly the result of microevolution and is relevant to studies into the effect of tailored drug treatment...
  34. ncbi Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles
    Lei Yang
    School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang City, Liaoning, China
    Int J Pharm 340:163-72. 2007
    ..These results suggest that the HCPT-BSA nanoparticles seem to be a stable delivery system for poorly soluble HCPT or its derivatives...
  35. ncbi Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin
    Zhiyong Han
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 277:17154-60. 2002
    ..These observations demonstrated that p21 was required for senescence development of HCT116 cells following treatment with low concentrations of CPT...
  36. ncbi Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918
    M Maliepaard
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Clin Cancer Res 7:935-41. 2001
    ..This observation may have important clinical implications for future development of novel camptothecins...
  37. ncbi Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors
    L B Saltz
    Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 14:2959-67. 1996
    ....
  38. ncbi Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    S M Galbraith
    Tumour Microcirculation Group, Gray Laboratory Cancer Research Trust, Northwood, HA6 2JR
    Anticancer Res 21:93-102. 2001
    ..Differences in the recovery from the shape changes induced by CA4P and colchicine could underlie the different toxicity profiles of these drugs...
  39. ncbi Docetaxel and cisplatin: an active regimen in patients with locally advanced, recurrent or metastatic squamous cell carcinoma of the head and neck. Results of a phase II study of the EORTC Early Clinical Studies Group
    P Schoffski
    Department of Hematology Oncology, Hannover University Medical School, Germany
    Ann Oncol 10:119-22. 1999
    ..The EORTC ECSG performed a multicenter phase II study in patients with locally advanced, recurrent or metastatic squamous cell carcinoma of the head and neck to evaluate the antitumor efficacy and toxicity of this combination...
  40. ncbi Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse
    M Mahyar-Roemer
    Internal Medicine IV, University of Saarland Medical School, Homburg/Saar, Germany
    Int J Cancer 94:615-22. 2001
    ..Remarkably, apoptosis was preceded by mitochondrial proliferation and signs of epithelial differentiation. Thus, resveratrol triggers a p53-independent apoptotic pathway in HCT116 cells that may be linked to differentiation...
  41. ncbi Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis
    X H Yang
    Lurie Cancer Center, Northwestern University Medical School, Evanston Northwestern Healthcare, Illinois 60201, USA
    Cancer Res 61:348-54. 2001
    ..Our results also suggest that caspase 3 deficiency may contribute to chemotherapeutic resistance in breast cancer...
  42. pmc The biology of the combretastatins as tumour vascular targeting agents
    Gillian M Tozer
    Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Int J Exp Pathol 83:21-38. 2002
    ..This paper reviews the current understanding of the mechanism of action of the combretastatins and their therapeutic potential...
  43. pmc Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens
    J S Kloover
    Department of Pulmonology, Erasmus MC, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Br J Cancer 90:304-5. 2004
    ..The level of evidence supporting the short-course i.v. premedication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone...
  44. ncbi Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Int J Oncol 31:277-83. 2007
    ..It is possible that therapeutic benefits such as the restoration of chemosensitivity or suppression of metastasis will be enabled by gaining further insight into the mechanisms underlying chemoresistance and EMT...
  45. ncbi Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein
    Yun Jin Jung
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Rockville, Maryland 20850, USA
    J Biol Chem 278:7445-52. 2003
    ..Collectively, these data support a model in which NFkappaB is a focal point for the convergence of MDA-mediated signaling events leading to HIF-1 induction, thus revealing a novel aspect of HIF-1alpha regulation and function...
  46. ncbi Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
    Bolleddula Jayaprakasam
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture, Michigan State University, East Lansing, MI 48824, USA
    Cancer Lett 189:11-6. 2003
    ..Vioxx showed specific COX-2 inhibition by 71%. Also, cucurbitacins 1 and 4 inhibited lipid peroxidation by 59 and 23%, respectively, at 100 microg/ml...
  47. ncbi Treatment of epigallocatechin-3-gallate inhibits matrix metalloproteinases-2 and -9 via inhibition of activation of mitogen-activated protein kinases, c-jun and NF-kappaB in human prostate carcinoma DU-145 cells
    Praveen K Vayalil
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Prostate 59:33-42. 2004
    ..Therefore, the effect of (-)-epigallocatechin-3-gallate (EGCG) was determined on the synthesis and activation of tumor invasion-specific MMP-2 and MMP-9 in human prostate carcinoma DU-145 cells...
  48. ncbi Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells
    Jun Hyuk Lee
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 21:1239-44. 2002
    ..These results suggest that tetrandrine merits further investigation as a cell cycle blocker as well as a cancer chemopreventive agent...
  49. ncbi The c-Jun NH(2)-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine
    M Fan
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205-7199, USA
    Cancer Res 61:4450-8. 2001
    ....
  50. ncbi beta-Sitosterol activates Fas signaling in human breast cancer cells
    A B Awad
    Department of Exercise and Nutrition Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Phytomedicine 14:747-54. 2007
    ..These findings support the hypothesis that beta-sitosterol is an effective apoptosis-promoting agent and that incorporation of more phytosterols in the diet may serve a preventive measure for breast cancer...
  51. doi Anticancer activity of isoobtusilactone A from Cinnamomum kotoense: involvement of apoptosis, cell-cycle dysregulation, mitochondria regulation, and reactive oxygen species
    Chung Yi Chen
    School of Medicine and Health Sciences, Fooyin University, Kaohsiung County 831, Taiwan, Republic of China
    J Nat Prod 71:933-40. 2008
    ..Finally, we found that IOA inhibited the migration and invasion of A549 cell migration and invasion. Taken together, these results suggest that IOA has anticancer effects on A549 cells...
  52. ncbi Taxol induces caspase-10-dependent apoptosis
    Soo Jung Park
    Department of Pharmacology and Toxicology and Indiana University Cancer Center, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:51057-67. 2004
    ..Therefore, these results demonstrate for the first time that taxol induces FADD-dependent apoptosis primarily through activation of caspase-10 but independently of death receptors...
  53. ncbi Neoadjuvant chemotherapy in breast cancer: significantly enhanced response with docetaxel
    Ian C Smith
    Department of Academic Radiology, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
    J Clin Oncol 20:1456-66. 2002
    ..To compare the efficacy of neoadjuvant (NA) docetaxel (DOC) with anthracycline-based therapy and determine the efficacy of NA DOC in patients with breast cancer initially failing to respond to anthracycline-based NA chemotherapy (CT)...
  54. ncbi Resveratrol-induced apoptotic death in human U251 glioma cells
    Hao Jiang
    William T Gossett Neurology Laboratories, Henry Ford Health System, Detroit, Michigan 48202, USA
    Mol Cancer Ther 4:554-61. 2005
    ..These results suggest that multiple signaling pathways may underlie the apoptotic death of U251 glioma induced by resveratrol, which warrants further exploration as an anticancer agent in human glioma...
  55. ncbi Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
    F A Shepherd
    University of Toronto, Toronto, and London Regional Cancer Centre, London, Ontario, Canada
    J Clin Oncol 18:2095-103. 2000
    ..Secondary end points included assessment of response (docetaxel arm only), toxicity, and quality of life...
  56. pmc Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells
    C Zhang
    Molecular and Nano Sciences Laboratory, Department of Physics, Tsinghua University, Beijing 100084, China
    Biochem J 355:653-61. 2001
    ..formation via the Fenton reaction. The finding that ROS is involved in the TCS-induced apoptosis of JAR cells might provide new insight into the anti-tumour and anti-HIV mechanism of TCS...
  57. ncbi Disrupting tumour blood vessels
    Gillian M Tozer
    Academic Unit of Surgical Oncology, Division of Clinical Sciences, University of Sheffield, Floor K, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    Nat Rev Cancer 5:423-35. 2005
    ....
  58. ncbi Phase III trial comparing three doses of docetaxel for second-line treatment of advanced breast cancer
    Vernon Harvey
    Department of Oncology, Auckland Hospital, Private Bag 92 024, Auckland, New Zealand
    J Clin Oncol 24:4963-70. 2006
    ..To evaluate whether a relationship exists between docetaxel dose and clinical response in the treatment of patients with advanced breast cancer...
  59. ncbi Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types
    Jan H Kessler
    Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Lett 251:132-45. 2007
    ..Our results substantiate the possible application of BA as a chemotherapeutic agent for the most prevalent human cancer types...
  60. ncbi Mechanisms of antiprostate cancer by gum mastic: NF-kappaB signal as target
    Mei Lan He
    Institute of Cancer Research, Life Science and Technology School, Tongji University, Shanghai 200092, China
    Acta Pharmacol Sin 28:446-52. 2007
    ....
  61. ncbi Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage
    Noritaka Adachi
    Kihara Institute for Biological Research, Graduate School of Integrated Science, Yokohama City University, Totsuka ku, Yokohama 244 0813, Japan
    J Biol Chem 278:35897-902. 2003
    ..The outstandingly increased cytotoxicity of topo II inhibitors in the absence of NHEJ suggests that simultaneous inhibition of topo II and NHEJ would provide a powerful protocol in cancer chemotherapy involving topo II inhibitors...
  62. pmc A phase II study of docetaxel in patients with metastatic squamous cell carcinoma of the head and neck
    C Couteau
    Institut Gustave Roussy, Department of Medecine, Villejuif, France
    Br J Cancer 81:457-62. 1999
    ..3%). A mean clearance of 19.6 l h(-1) m(-2) and an area under the curve of 6.00 microg ml(-1) h(-1) was found in the pharmacokinetic analysis. Docetaxel is active in this selected population with metastatic SCCHN, with a good tolerance...
  63. ncbi AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    Shubha Anand
    CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cancer Cell 3:51-62. 2003
    ..Consistent with this conclusion, elevated Aurora-A expression causes resistance to apoptosis induced by Taxol in a human cancer cell line...
  64. ncbi Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells
    Asok Banerjee
    Department of Biochemistry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochem Biophys Res Commun 293:598-601. 2002
    ..These results demonstrate for the first time that PTX resistance is associated with an increase in the level of tyrosinated alpha-tubulin...
  65. ncbi Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chemotherapy 53:257-62. 2007
    ..Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds...
  66. ncbi A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer
    Andreas du Bois
    Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken, Wiesbaden, Germany
    J Natl Cancer Inst 95:1320-9. 2003
    ..Therefore, we performed a randomized, phase III non-inferiority trial comparing paclitaxel plus cisplatin (PT) with paclitaxel plus carboplatin (TC) in patients with advanced ovarian cancer...
  67. ncbi Effects of cryotherapy or chemotherapy on apoptosis in a non-small-cell lung cancer xenografted into SCID mice
    Valérie Forest
    UPRES EA3063, Faculte de Medecine Jacques Lisfranc, 15 rue Ambroise Paré, 42023 Saint Etienne cedex 2, France
    Cryobiology 50:29-37. 2005
    ..Taken together, these results demonstrate the differential effects of cryotherapy and chemotherapy in vivo, suggesting different modes of action and the potential benefit to combine them...
  68. ncbi Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells
    Wanzhou Zhao
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No1 Xiannong Tan Street, Beijing 100050, China
    Cancer Detect Prev 27:67-75. 2003
    ....
  69. doi Protein nanoparticles as drug carriers in clinical medicine
    Michael J Hawkins
    Abraxis Bioscience, Inc, Los Angeles, CA 90025, USA
    Adv Drug Deliv Rev 60:876-85. 2008
    ..The nab technology promises to have broad utility in cancer therapy, and clinical trials are underway using nab formulations of other water-insoluble anticancer agents such as docetaxel and rapamycin...
  70. ncbi The effect of willow leaf extracts on human leukemic cells in vitro
    Hany A El-Shemy
    Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt
    J Biochem Mol Biol 36:387-9. 2003
    ..After a 24-h incubation in vitro, the crude water extracts of the leaves killed a majority of the blasts of acute myeloid leukemia (AML, 73.8%)...
  71. ncbi High efficacy of docetaxel with and without androgen deprivation and estramustine in preclinical models of advanced prostate cancer
    Karim Fizazi
    Department of Medicine, Institut Gustave Roussy, Villejuif, France
    Anticancer Res 24:2897-903. 2004
    ..To assess the activity of docetaxel in combination with hormonal therapy in preclinical models of prostate cancer...
  72. ncbi Effect of docetaxel on the therapeutic ratio of fractionated radiotherapy in vivo
    K A Mason
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Cancer Res 5:4191-8. 1999
    ....
  73. ncbi An effective and more convenient drug regimen for prophylaxis against paclitaxel-associated hypersensitivity reactions
    M Markman
    Department of Hematology Medical Oncology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cancer Res Clin Oncol 125:427-9. 1999
    ....
  74. ncbi Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia
    K V Balan
    Department of Biology, University of Miami, Coral Gables, Miami, FL, USA
    Phytomedicine 14:263-72. 2007
    ....
  75. ncbi Involvement of the retinoblastoma (pRb)-E2F/DP pathway during antiproliferative effects of resveratrol in human epidermoid carcinoma (A431) cells
    V M Adhami
    Department of Dermatology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biochem Biophys Res Commun 288:579-85. 2001
    ..To our knowledge, this is the first study showing the involvement of the pRb-E2F/DP pathway as a mechanism of the cancer-chemopreventive effects of resveratrol...
  76. ncbi The cytoplasmic trafficking of DNA topoisomerase IIalpha correlates with etoposide resistance in human myeloma cells
    Roxane Engel
    Experimental Therapeutics Program, Departments of Interdisciplinary Oncology and Biochemistry and Molecular Biology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Exp Cell Res 295:421-31. 2004
    ..It appears that the nuclear-cytoplasmic shuttling of topo IIalpha, which decreases the amount of nuclear target enzyme, is a major mechanism of drug resistance to topo II inhibitors in plateau-phase myeloma cells...
  77. pmc Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer
    L Paz-Ares
    Hospital Universitario 12 de Octubre, Servicio de Oncologia Medica, Madrid 28041, Spain
    Br J Cancer 98:1608-13. 2008
    ..Paclitaxel poliglumex at a dose of 210 mg m(-2) resulted in increased neurotoxicity compared with docetaxel...
  78. ncbi Enhanced transgene expression in androgen independent prostate cancer gene therapy by taxane chemotherapeutic agents
    Yingming Li
    Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
    J Urol 167:339-46. 2002
    ..We evaluated whether the chemotherapeutic agent docetaxel or paclitaxel may be combined with gene therapy to create a new therapeutic regimen for metastatic androgen independent prostate cancer...
  79. ncbi Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines
    Kohji Takara
    Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmacutical University, Misasagi, Japan
    Biol Pharm Bull 25:771-8. 2002
    ..The 27 anticancer drugs analyzed here could be classified into substrates and nonsubstrates for MDR1. This will be useful for designing effective regimens for chemotherapy...
  80. ncbi "Will weekly work"? Seems to be so
    Andrew D Seidman
    J Clin Oncol 23:5873-4. 2005
  81. ncbi Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
    Heidi LeBlanc
    Department of Molecular Oncology, Genentech, South San Francisco, California, USA
    Nat Med 8:274-81. 2002
    ..Thus, Bax mutation in mismatch repair--deficient tumors can cause resistance to death receptor--targeted therapy, but pre-exposure to chemotherapy rescues tumor sensitivity...
  82. ncbi Production of paclitaxel and the related taxanes by cell suspension cultures of Taxus species
    Homare Tabata
    Functional and Chemicals Laboratory, Mitsui Chemicals, Inc, 1144, Togo, Mobara shi, Japan
    Curr Drug Targets 7:453-61. 2006
    ..By applying the data from the two-stage culture and the high-density culture, a large-scale culture process was developed with a stable paclitaxel production in the range of 140-295 mg L(-1), reaching 295 mg L(-1) at maximum...
  83. ncbi p53 expression and resistance against paclitaxel in patients with metastatic breast cancer
    M Schmidt
    Department of Obstetrics and Gynaecology, University Hospital Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany
    J Cancer Res Clin Oncol 129:295-302. 2003
    ..Identifying these patients could spare them an ineffective treatment and could in turn characterize a subgroup of patients with a higher response rate...
  84. ncbi Back to basics: how natural products can provide the basis for new therapeutics
    Amit Deorukhkar
    The University of Texas MD Anderson Cancer Center, Department of Experimental Radiation Oncology, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Expert Opin Investig Drugs 16:1753-73. 2007
    ..This review focuses on the mechanism of action of key natural products and promising preclinical data on their efficacy as anticancer agents, as single agents and in combination with standard therapies...
  85. ncbi In vitro cytotoxic activity of Brazilian plant extracts against human lung, colon and CNS solid cancers and leukemia
    Ivana B Suffredini
    Laboratório de Extração da Universidade Paulista UNIP, Sao Paulo, SP, Brazil
    Fitoterapia 78:223-6. 2007
    ..Expressive activity was observed in the extracts of Toulicia cf. pulvinata, Ampirrhox sp., Macoubea sprucei, Calophyllum brasiliense, Vismia guianensis, Caryocar microcarpum, Xylopia aromatica and Distictella magnoliifolia...
  86. doi Are isothiocyanates potential anti-cancer drugs?
    Xiang Wu
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China
    Acta Pharmacol Sin 30:501-12. 2009
    ..This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents...
  87. ncbi Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen
    Mohamed Al-Fatimi
    Faculty of Medicine and Health Sciences, Pharmacy Section, Department of Pharmacognosy, Aden University, Aden, Yemen
    J Ethnopharmacol 111:657-66. 2007
    ..Remarkable cytotoxic activity against FL-cells was shown only for five plants, among them Plicosepalus curviflorus (stems)...
  88. pmc Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest
    Lingling Duan
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Mail Slot 516, 4301 W Markham Street, Little Rock, AR 72205, United States
    Biochem Pharmacol 73:481-90. 2007
    ..These results indicate that c-Jun expression plays a protective role in the cellular response to vinblastine and operates post-mitotic block to inhibit drug-induced apoptosis and senescence...
  89. doi Purine-containing cucurbitane triterpenoids from Cucurbita pepo cv dayangua
    Da Cheng Wang
    School of Veterinary Science, Jilin University, Jilin 130062, China
    Phytochemistry 69:1434-8. 2008
    ..Cucurbitaglycosides A and B showed cytotoxic activity against the human epithelial carcinoma cell line HeLa with IC50 of 17.2 and 28.4 microg/mL, respectively...
  90. ncbi Dietary polyphenolic phytochemicals--promising cancer chemopreventive agents in humans? A review of their clinical properties
    Sarah C Thomasset
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Int J Cancer 120:451-8. 2007
    ....
  91. doi Herbal extract "Songyou Yin" inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential
    Xiu Yan Huang
    Department of General Surgery, The 6th People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
    J Cancer Res Clin Oncol 135:1245-55. 2009
    ..This study evaluates the effect of the herbal compound extract "Songyou Yin" (containing Salvia miltiorrhiza Bge.-danshen and other four herbs) on hepatocellular carcinoma (HCC)...
  92. doi Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-kappaB, and ERK-2
    Narayanan Sriram
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu 600 025, India
    Mol Cell Biochem 311:157-65. 2008
    ..In conclusion, DAS increased the production of ROS, caused cell cycle arrest, decreased cell proliferation and induced apoptosis in Colo 320 DM cells. Thus, this study put forward DAS as a drug that can possibly be used to treat cancers...
  93. ncbi Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer
    Jenny C Chang
    Breast Center and the Departments of Medicine, Pathology, and Molecular and Cellular Biology, Baylor College of Medicine, and The Methodist Hospital, Houston, TX 77030, USA
    Lancet 362:362-9. 2003
    ..Patients often have de novo resistance or incomplete response to docetaxel, one of the most active agents in this disease. We postulated that gene expression profiles of the primary breast cancer can predict the response to docetaxel...
  94. ncbi Study of the anticancer potential of Yemeni plants used in folk medicine
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Yemen
    Pharmazie 62:305-7. 2007
    ..29 and 5.54 microg/ml. The extracts of Jatropha unicostata and Punica protopunica showed a moderate potency on the most tumor cell lines...
  95. pmc Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats
    D Hunter Best
    Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Hepatol 46:1055-63. 2007
    ....
  96. ncbi VP-16 resistance in the NCI-H460 human lung cancer cell line is significantly associated with glucose-regulated protein78 (GRP78) induction
    Qi Wang
    Department of Respiratory Medicine, the Second Hospital affiliated to Dalian Medical University, Dalian 116023, China
    Anticancer Res 27:2359-64. 2007
    ..To investigate the relationship between the expression of glucose-regulated protein (GRP78) and resistance to VP-16 in the NCI-H460 cell line...
  97. ncbi The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme
    Kyungsu Kang
    Natural Products Research Center, Korea Institute of Science and Technology, Gangneung 210 340, Korea
    Biol Pharm Bull 30:2352-9. 2007
    ..These data suggest that the extract as well as the lignan compounds (especially arctigenin) originated from Saussurea salicifolia may be served as potential cancer chemopreventive agents for prevention or treatment of human cancers...
  98. ncbi In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel
    F Lacoeuille
    Inserm U646, 10 rue A Boquel, F 49100 Angers, France
    Int J Pharm 344:143-9. 2007
    ..These results demonstrate the great interest to use LNC as drug delivery system for paclitaxel, permitting with an equivalent therapeutic efficiency to avoid the use of excipients such as polyoxyethylated castor oil for its formulation...
  99. pmc The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel
    Ahmed Ashour Ahmed
    Functional Genomics of Drug Resistance Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cancer Cell 12:514-27. 2007
    ..These data show that ECM can mediate taxane sensitivity by modulating microtubule stability...
  100. ncbi Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin
    Jonathan P Carson
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 64:2096-104. 2004
    ....
  101. doi Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins
    Charles Gauthier
    Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
    J Nat Prod 72:72-81. 2009
    ..8-1.9 microM)...

Research Grants123 found, 100 shown here

  1. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  2. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  3. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2005
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs directed at improving human cancer treatments. ..
  4. Gene Transfer to Facilitate Dose-Intensification in the Treatment of Pediatric B*
    Lars Wagner; Fiscal Year: 2007
    ..We hypothesize this strategy will be well tolerated and allow for meaningful dose escalation through chemoprotection afforded by gene transfer into hematopoietic stem cells. ..
  5. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
    ....
  6. Design of Gene Delivery System to Target Hepatocytes
    Mark Davis; Fiscal Year: 2007
    ..The long-term objective of our proposal is to design and engineer a generalized, synthetic system for ultimately delivering nucleic acid-based therapeutics to hepatocytes in humans. ..
  7. NATIONAL WILMS TUMOR STUDY -5
    Daniel Green; Fiscal Year: 2003
    ..The survival of most children treated for WT allows the study of genetic and treatment factors associated with the etiology of the disease and/or the occurrence of complications of therapy. ..
  8. Phase I Clinical Trials of Anti-Cancer Agents
    Mark Ratain; Fiscal Year: 2007
    ..This application also includes a proposal for the creation of an Early Clinical Trials Network to facilitate inter-institutional collaborations involving NCI-sponsored early clinical trials. ..
  9. ENHANCING RADIATION THERAPY: VASCULAR TARGETING AGENTS
    Dietmar Siemann; Fiscal Year: 2007
    ....
  10. Reversal of 5-FU Resistance by Arsenic Trioxide in Colorectal Carcinoma
    Bach Ardalan; Fiscal Year: 2007
    ..Aim 2: Determine if ATO administration down regulates the expression of thymidylate synthase in tumor and in PBMC in patients receiving ATO + 5-FU. ..
  11. Neural Progenitor Cells as Cancer Therapy Vectors
    MARY DANKS; Fiscal Year: 2007
    ..The described approach might then be adapted to the treatment of other solid tumors by careful choice of appropriate therapeutic transgenes. ..
  12. EASTERN COOPERATIVE ONCOLOGY GROUP
    Joseph Sparano; Fiscal Year: 2007
    ....
  13. MECHANISM OF ACTION OF THE ANTITUMOR DRUG TAXOL
    Mary Jordan; Fiscal Year: 2002
    ..Understanding the linkage between microtubule dynamics, mitotic block, and resistance to taxol promises to lead to new drug targets that will improve the efficacy of chemotherapy. ..
  14. TNF Blockade in Pancreatic Cancer Patients
    MIGUEL VILLALONA; Fiscal Year: 2004
    ..The observation of benefits in either quality of life or progression-free survival in patients undergoing TNF blockade would encourage evaluation of this novel strategy in properly powered randomized clinical trials. ..
  15. Biomodulation of capecitabine by docetaxel in non-small*
    MIGUEL VILLALONA; Fiscal Year: 2005
    ..Confirmation of our working hypothesis may lead to a new treatment paradigm suitable for evaluation in the adjuvant setting. ..
  16. LIPOSOMAL BCL-2 ANTISENSE THERAPY FOR SOLID TUMORS
    Francisco Esteva; Fiscal Year: 2003
    ..Gabriel Lopez-Berestein (Department of Bioimmunotherapy). M. D. Anderson Cancer Center has the patients and resources necessary for Dr. Esteva to successfully complete this research project. ..
  17. Pharmacogenetic Determinants of Vinca Alkaloid Response
    Jamie Renbarger; Fiscal Year: 2005
    ....
  18. SYNTHESIS AND BIOSYNTHESIS IN THE SHIKIMATE PATHWAY
    Bruce Ganem; Fiscal Year: 1999
    ..The corresponding syn-stereoisomer will be synthesized and evaluated, since SN2' displacements are known to occur with either syn or antistereochemistry in nonenzymatic systems. ..
  19. CLINICAL THERAPEUTICS
    Mark Ratain; Fiscal Year: 2007
    ..abstract_text> ..
  20. Mitochondrial Oxidative Stress In Angiotensis II Induced Endothelial Dysfunction
    Sergey Dikalov; Fiscal Year: 2010
    ..This work will study the role of mitochondrial oxidative stress in endothelial dysfunction and provide a novel therapeutic target to treat and prevent hypertension. ..
  21. Combining Anti-Angiogenesis Strategies and Radiotherapy
    Dietmar W Siemann; Fiscal Year: 2010
    ..Experiments are designed to investigate the mechanisms underlying the interaction between such therapies and to develop approaches that would maximize the anti-tumor efficacy of such combined treatments. ..
  22. Targeting Somatic Homologous Recombination in Solid Tumors
    MIGUEL ANGEL VILLALONA; Fiscal Year: 2010
    ..We hypothesize that these patients will derive substantial clinical benefit from such treatment. ..
  23. Predictive Markers of Glioblastoma Response to VEGF Trap
    John de Groot; Fiscal Year: 2007
    ..These studies are critical for establishing which biomarkers are useful in predicting patient response and monitoring treatment progress, as well as forming a baseline for biomarker studies for future trials with anti-VEGF therapies. ..
  24. MENTORING & ADVANCED RESEARCH TRAINING FOR WRHR SCHOLARS
    Jonathan Berek; Fiscal Year: 2007
    ..This cadre of Scholars will be among future leaders in women's reproductive health research in the United States. ..
  25. Resveratrol-induced apoptotic cell death in glioma
    Hao Jiang; Fiscal Year: 2007
    ..By elucidating the molecular mechanisms underlying the therapeutic effects of resveratrol, this study would facilitate the development of therapeutic agents using natural products and greatly improve the treatment of brain tumors. ..
  26. PHARMACOGENETICS OF ANTICANCER AGENTS RESEARCH GROUP
    Mark Ratain; Fiscal Year: 2007
    ....
  27. A Novel Method of Nanoparticle Delivery to Brain by Targeting Ec-gp96
    Mark E Davis; Fiscal Year: 2010
    ....
  28. Non-Viral Vectors for Liver Gene Transfer
    Feng Liu; Fiscal Year: 2006
    ..The therapeutic effects on the metabolic disease on phenylketonuria (PKU) mice, will be examined after the PAH gene transfer using the approach in this proposal. ..
  29. Identification of Anti-Viral Compounds from Plants
    Shiyou Li; Fiscal Year: 2005
    ..abstract_text> ..
  30. MOLECULAR DETERMINANTS OF MULTICELLULAR ORGANIZATION
    Douglas Hixson; Fiscal Year: 1992
    ..These studies will provide new insight into molecular events involved in the formation of histotypic interactions and changes in these events that lead to the aberrant interactions characteristic of malignant cells...
  31. CELLULAR ORIGINS OF LIVER CANCER
    Douglas Hixson; Fiscal Year: 1993
    ..Identification of unique integration sites held in common between oval cells and hepatocytes, focal lesions, nodules or primary tumors will provide unequivocal evidence for precursor-product relationships...
  32. Genesis of Liver Carcinomas with Oval Cell Traits
    Douglas Hixson; Fiscal Year: 2007
    ..We will test the hypothesis that loss of BD.1 alters microtubule/kinetochore dynamics in a manner that promotes aneuploidy. The proposed studies will provide new insights into the role of bipotent progenitors in liver cancer. ..
  33. CANCER AND LEUKEMIA GROUP B--PET COMMITTEE
    Mark Ratain; Fiscal Year: 2002
    ..Since many of the studies include analysis of pharmacological specimens, the Committee utilizes three core laboratories--at the University of Chicago, the University of Maryland and the University of Tennessee. ..
  34. MOLECULAR DETERMINANTS OF MULTICELLULAR ORGANIZATION
    Douglas Hixson; Fiscal Year: 2003
    ..The proposed studies will provide new insights into the role of C-CAM in the interactions of normal hepatocytes and the consequences of the loss of C-CAM during liver carcinogenesis. ..