non steroidal anti inflammatory agents

Summary

Summary: Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or phospholipase C or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)

Top Publications

  1. ncbi Curcumin: the Indian solid gold
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Adv Exp Med Biol 595:1-75. 2007
  2. pmc EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, UK
    Ann Rheum Dis 64:669-81. 2005
  3. ncbi Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia
    JAMA 296:1633-44. 2006
  4. ncbi A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy
    Laurence Maiden
    Department of Medicine, Guy s, King s, St Thomas Medical School, London, England
    Gastroenterology 128:1172-8. 2005
  5. ncbi Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 369:1603-13. 2007
  6. pmc Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
    Julia Hippisley-Cox
    Institution 13th floor, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 330:1366. 2005
  7. ncbi Coxibs and cardiovascular disease
    Garret A Fitzgerald
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 351:1709-11. 2004
  8. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
  9. ncbi Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient
    L Laine
    University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Gastroenterology 120:594-606. 2001
  10. ncbi COX-2: a target for colon cancer prevention
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 42:55-80. 2002

Detail Information

Publications317 found, 100 shown here

  1. ncbi Curcumin: the Indian solid gold
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Adv Exp Med Biol 595:1-75. 2007
    ..g., HERCEPTIN). Considering the recent scientific bandwagon that multitargeted therapy is better than monotargeted therapy for most diseases, curcumin can be considered an ideal "Spice for Life"...
  2. pmc EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, UK
    Ann Rheum Dis 64:669-81. 2005
    ..To develop evidence based recommendations for the management of hip osteoarthritis (OA)...
  3. ncbi Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia
    JAMA 296:1633-44. 2006
    ..Regulatory agencies have provided variable advice regarding the cardiovascular risks with older nonselective NSAIDs...
  4. ncbi A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy
    Laurence Maiden
    Department of Medicine, Guy s, King s, St Thomas Medical School, London, England
    Gastroenterology 128:1172-8. 2005
    ..We used wireless capsule enteroscopy to quantitate and assess the nature of the small bowel damage caused by nonsteroidal anti-inflammatory drugs when taken on a short-term basis...
  5. ncbi Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 369:1603-13. 2007
    ..However, the delay from the early development of adenoma to presentation with cancer is at least 10 years. We aimed to assess the longer-term effect of aspirin on the incidence of cancers...
  6. pmc Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
    Julia Hippisley-Cox
    Institution 13th floor, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 330:1366. 2005
    ....
  7. ncbi Coxibs and cardiovascular disease
    Garret A Fitzgerald
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 351:1709-11. 2004
  8. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
    ..Finally, we suggest research opportunities that may help to accelerate the future clinical application of NSAIDs for cancer prevention or treatment...
  9. ncbi Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient
    L Laine
    University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Gastroenterology 120:594-606. 2001
    ..This review discusses the risks of clinical GI disease in NSAID users, the predictors of increased risk, and strategies for prevention of NSAID-associated GI disease...
  10. ncbi COX-2: a target for colon cancer prevention
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 42:55-80. 2002
    ..It is hoped that, as the genome sequence is understood more clearly, other targets will emerge that will provide even more effective drugs for future cancer prevention...
  11. ncbi Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies
    Fernando S Velayos
    Division of Gastroenterology and UCSF Center for Colitis and Crohn s Disease, University of California, San Francisco, California 94143, USA
    Am J Gastroenterol 100:1345-53. 2005
    ..We performed a systematic review with metaanalysis of observational studies evaluating the association between 5-ASA use and colorectal cancer (CRC) or dysplasia among patients with ulcerative colitis...
  12. ncbi Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells
    Siyuan Zhang
    Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, 16 Medical Drive, Singapore 117597
    Cancer Lett 208:143-53. 2004
    ..These data clearly demonstrate that the intracellular thiols and calcium equilibrium play a critical role in parthenolide-induced apoptotic cell death...
  13. ncbi Adherence to proton pump inhibitors or H2-receptor antagonists during the use of non-steroidal anti-inflammatory drugs
    M C J M Sturkenboom
    Department of Epidemiology and Biostatistics, Medical Informatics, Erasmus University, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 18:1137-47. 2003
    ..The efficacy of proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs) prescribed as prophylaxis for NSAID-related upper gastrointestinal (UGI) toxicity is dependent upon patient adherence...
  14. ncbi The effects of Ginkgo biloba extract on lipopolysaccharide-induced inflammation in vitro and in vivo
    Iliyana Ilieva
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Exp Eye Res 79:181-7. 2004
    ..7) treated with GBE in vitro to clarify the anti-inflammatory effect...
  15. ncbi Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells
    Jingchun Gao
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194
    Cancer Sci 95:901-7. 2004
    ..A cytochrome c-dependent apoptotic pathway and/or cell cycle arrest may contribute to the inhibitory effects of these NSAIDs...
  16. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
    ..We also compare the concentrations of these inhibitors used in in vitro and in vivo experiments and discuss the implications of the in vitro studies for clinical management of cancer with these drugs...
  17. ncbi Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide
    Jing Wen
    Division of Gastroenterology and Hepatology, Departments of Internal Medicine and Anatomy Research Institute for Clinical Medicine, Chonbuk National University Medical School and Hospital, Chonju, Chonbuk 561 712, Republic of Korea
    J Biol Chem 277:38954-64. 2002
    ..Finally, parthenolide and its derivatives may be useful chemotherapeutic agents to treat these invasive cancers...
  18. ncbi Pathogenesis of aspirin-exacerbated respiratory disease
    Donald D Stevenson
    Allergy and Immunology Division, Scripps Clinic and the Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Rev Allergy Immunol 24:169-88. 2003
    ..It is more likely that a diminution in number or function of cysLT receptors accounts for the diminished inflammatory response found in ASA desensitization...
  19. ncbi NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action
    Syeda S Husain
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Am J Gastroenterol 97:542-53. 2002
    ....
  20. ncbi Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia
    J Musial
    Department of Medicine, Jagiellonian University School of Medicine, Skawinska 8, 31 066, Krakow, Poland
    Int J Cardiol 77:247-53. 2001
    ..The aim of the study was to assess the influence of simvastatin and aspirin on serum levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in hypercholesterolemic subjects...
  21. ncbi Visible small-intestinal mucosal injury in chronic NSAID users
    David Y Graham
    Department of Medicine, VA Medical Center, Room 3A 320 111D, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 3:55-9. 2005
    ..The prevalence and severity of small-intestinal lesions remains unclear. Our aim was to assess the frequency of NSAID-induced small-bowel injury among chronic NSAID users...
  22. ncbi Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study
    Thomas L Vaughan
    Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109, USA
    Lancet Oncol 6:945-52. 2005
    ..We aimed to assess the role of NSAID in the development of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesophageal adenocarcinoma...
  23. ncbi The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    FEBS Lett 500:52-5. 2001
    ..These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens...
  24. doi Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
    Lancet Oncol 10:501-7. 2009
    ..The main side-effect of aspirin is peptic ulcers; therefore coadministration of aspirin with a proton-pump inhibitor is an attractive option and is under investigation in the AspECT trial...
  25. ncbi Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial
    Peter S Tugwell
    Centre for Global Health, Institute of Population Health, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 31:2002-12. 2004
    ..To compare the safety and efficacy of a topical diclofenac solution versus oral diclofenac in relieving the symptoms of primary osteoarthritis (OA) of the knee, in a randomized, double-blind, double-dummy equivalence trial...
  26. ncbi Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat
    S Somasundaram
    Departments of Medicine and Surgery, Guy s, King s and St Thomas Medical School, Camberwell, UK
    Aliment Pharmacol Ther 14:639-50. 2000
    ..One suggestion is that the nonprostaglandin mechanism involves uncoupling of mitochondrial oxidative phosphorylation...
  27. doi Increased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failure
    Gunnar H Gislason
    Department of Cardiology, Gentofte University Hospital, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Arch Intern Med 169:141-9. 2009
    ..We studied the risk of death and hospitalization because of acute myocardial infarction and heart failure (HF) associated with use of NSAIDs in an unselected cohort of patients with HF...
  28. ncbi Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities
    S J Baek
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 59:901-8. 2001
    ..These data demonstrate that NAG-1 is an antitumorigenic and proapoptotic protein, and its regulation by COX inhibitors may provide new clues for explaining their proapoptotic and antitumorigenic activities...
  29. ncbi Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    R Langenbach
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cell 83:483-92. 1995
    ..Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2...
  30. ncbi Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
    Karen V Andersen
    Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 78:180-6. 2007
    ..We compared wound infiltration combined with intraarticular injection of local anesthetics for pain relief after total hip arthroplasty (THA) with the well-established practice of epidural infusion...
  31. ncbi Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial
    Sanford H Roth
    Arizona Research and Education, Phoenix, USA
    Arch Intern Med 164:2017-23. 2004
    ..A new topical diclofenac sodium solution-containing the absorption enhancer dimethyl sulfoxide-was evaluated for the relief of the symptoms of primary OA of the knee...
  32. ncbi Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:711-8. 2005
    ....
  33. ncbi Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    Tony Wyss-Coray
    Geriatric Research, Education and Clinical Center, Veterans Administration Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
    Nat Med 12:1005-15. 2006
    ..Related factors, on the other hand, elicit beneficial responses and can reduce disease...
  34. doi Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study
    Ulla Vogel
    National Research Centre for the Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 639:89-100. 2008
    ..p for interaction was 3 x 10(-6) for COX-2 A-1195G and 9 x 10(-5) for PPARgamma2 Pro(12)Ala. The results suggest that NSAID use may modify risk of lung cancer differently depending on the genotype...
  35. ncbi A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  36. ncbi Systematic review: adherence issues in the treatment of ulcerative colitis
    S V Kane
    Section of Gastroenterology, Department of Medicine, The University of Chicago, Chicago, IL, USA
    Aliment Pharmacol Ther 23:577-85. 2006
    ..It is a combination of understanding patient behaviour, recognizing signs of non-adherent behaviour and utilizing management strategies to change behaviour that will improve patient outcomes...
  37. ncbi Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Oncogene 23:7330-44. 2004
    ..These results identify a new antitumor activity of parthenolide, which can be exploited to reverse resistance of cancer cells to TRAIL, particularly those with elevated XIAP levels...
  38. ncbi Cyclooxygenase-2 inhibitors in tumorigenesis (Part II)
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Japan
    J Natl Cancer Inst 90:1609-20. 1998
    ..This Part II (of a two-part review) focuses on the growing clinical and experimental evidence that NSAIDS and COX-2 inhibitors can influence the risk of colon (and possibly of other) cancers...
  39. ncbi The epidemiology of nonsteroidal anti-inflammatory drugs
    J Tenenbaum
    Mount Sinai Hospital, Toronto, Canada
    Can J Gastroenterol 13:119-22. 1999
    ..Although no NSAID is totally safe, a number of studies have demonstrated that NSAIDs may be ranked according to relative gastrointestinal toxicity. The role of Helicobacter pylori in NSAID-associated problems remains uncertain...
  40. ncbi Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    M Yuan
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Science 293:1673-7. 2001
    ..These findings implicate an inflammatory process in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus and identify the IKKbeta pathway as a target for insulin sensitization...
  41. ncbi Celecoxib for the prevention of colorectal adenomatous polyps
    Nadir Arber
    Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    N Engl J Med 355:885-95. 2006
    ..Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention...
  42. pmc Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty
    Per Essving
    Department of Orthopedic Surgery, University of Linkoping, Sweden
    Acta Orthop 80:213-9. 2009
    ..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...
  43. doi Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial
    Roy D Altman
    Department of Rheumatology and Immunology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    J Rheumatol 36:1991-9. 2009
    ..To measure the efficacy and safety of diclofenac sodium gel in patients with primary hand osteoarthritis (OA)...
  44. doi Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats
    Feng Jin
    Department of Pharmacology, Zunyi Medical College, Zunyi, PR China
    Eur J Pharmacol 600:78-82. 2008
    ..These results demonstrate that resveratrol exerts a neuroprotective effect on 6-OHDA-induced Parkinson's disease rat model, and this protection is related to the reduced inflammatory reaction...
  45. ncbi The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis
    N N Mahmoud
    The New York Hospital Cornell University Medical Center, NY 10021, USA
    Carcinogenesis 19:87-91. 1998
    ..001). These data suggest that the anti-tumor effect of sulindac in Apc-deficient animals is mediated by the sulfide metabolite and correlates with suppression of tissue prostaglandin synthesis...
  46. ncbi Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain
    Joan Fortuny
    Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Autonomous University of Barcelona corrected Barcelona, Catalonia, Spain
    Cancer Epidemiol Biomarkers Prev 15:1696-702. 2006
    ....
  47. ncbi Sites of action for future therapy: an adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFkappaB knockout mice
    B N Cronstein
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 550 First Ave, New York, NY, 10016, USA
    Osteoarthritis Cartilage 7:361-3. 1999
    ..This adenosine-dependent, antiinflammatory effect of aspirin points to another target of drug development...
  48. ncbi Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells
    M Adachi
    First Department of Internal Medicine, Graduate School of Medicine, Sapporo Medical University, Sapporo, Japan
    Histol Histopathol 22:437-42. 2007
    ..In this paper, we propose that increased ROS generation is one of the key mechanisms for NSAIDs-mediated anticancer effects on various cancer cells...
  49. ncbi The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat
    J R Dimar
    Department of Orthopaedic Surgery, University of Louisville School of Medicine, Kentucky, USA
    Spine (Phila Pa 1976) 21:1870-6. 1996
    ..Clinically, the widespread use of nonsteroidal anti-inflammatory drugs in the postoperative period after spinal fusion may need to be avoided...
  50. ncbi OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence
    W Zhang
    University of Edinburgh, Osteoarticular Research Group, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Osteoarthritis Cartilage 15:981-1000. 2007
    ....
  51. pmc Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
    Tilo Grosser
    Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:4-15. 2006
    ....
  52. ncbi A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
    Robert S Sandler
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7555, USA
    N Engl J Med 348:883-90. 2003
    ..Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most colorectal cancers...
  53. ncbi Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial
    Francis K L Chan
    Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Special Administrative Region of China, Hong Kong
    Lancet 359:9-13. 2002
    ..We hypothesised that eradication of H pylori infection would reduce the risk of ulcers for patients starting long-term NSAID treatment...
  54. ncbi Long-term NSAID use in primary care: changes over a decade and NICE risk factors for gastrointestinal adverse events
    P W Thompson
    Poole Hospital NHS Trust, Poole, Dorset BH15 2JB, UK
    Rheumatology (Oxford) 44:1308-10. 2005
    ..To assess numbers at risk of gastrointestinal adverse events using the National Institute for Clinical Excellence (NICE) guidance on the use of cyclo-oxygenase (Cox) II selective drugs...
  55. ncbi Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors
    Natsuko Kusunoki
    St Marianna University School of Medicine, Kawasaki, Japan
    Arthritis Rheum 46:3159-67. 2002
    ..This study was undertaken to investigate whether selective COX-2 inhibitors could induce apoptosis of RA synovial fibroblasts (RASFs)...
  56. ncbi The therapeutic potential of NO-NSAIDs
    John L Wallace
    f Pharmacology and Therapeutics, University of Calgary, Alberta, Canada
    Fundam Clin Pharmacol 17:11-20. 2003
    ..Recent clinical trials of NO-NSAIDs have provided a 'proof of concept' that is completely consistent with pre-clinical characterization of these compounds...
  57. pmc Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas
    Jason A Zell
    Chao Family Comprehensive Cancer Center, University of California, Irvine, California, USA
    Cancer Prev Res (Phila) 2:209-12. 2009
    ..These results have implications for future NSAID-based cancer prevention clinical trials...
  58. ncbi Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers
    F J Troost
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Clin Nutr 57:1579-85. 2003
    ....
  59. ncbi Nonsteroidal anti-inflammatory drugs in the elderly
    M Buffum
    Nursing Service for Research, VA Medical Center, School of Nursing, School of Pharmacy, University of California, San Francisco, CA, USA
    Pain Manag Nurs 1:40-50. 2000
    ..This article reviews current information about using NSAIDs in elderly persons...
  60. doi Scar treatments: preclinical and clinical studies
    Richard G Reish
    Division of Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Coll Surg 206:719-30. 2008
  61. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
    ..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...
  62. ncbi Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis
    Andrew Whelton
    Universal Clinical Research Center, Inc, and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21030 1603, USA
    Am J Cardiol 90:959-63. 2002
    ..7%) compared with the celecoxib group (4.7%) (p <0.05). Thus, in patients with controlled hypertension on a fixed antihypertensive regimen, careful monitoring of BP is warranted after the initiation of celecoxib or rofecoxib therapy...
  63. ncbi NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture
    W Tomisato
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan
    Am J Physiol Gastrointest Liver Physiol 281:G1092-100. 2001
    ..These results imply that NSAIDs cause gastric mucosal damage through both necrosis and apoptosis of gastric mucosal cells...
  64. ncbi Targeting cyclooxygenase-2 in human neoplasia: rationale and promise
    Andrew J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, NY 10021, USA
    Cancer Cell 4:431-6. 2003
  65. ncbi Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha
    Xin Liu
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Epidemiol 164:984-9. 2006
    ..30). The authors observed similar associations when examining dose/duration of NSAID use. This suggests that any potential chemoprevention of prostate cancer by NSAIDs may be most appropriate for men with the LTA +80CC genotype...
  66. pmc Non-steroidal anti-inflammatory drugs and bladder cancer prevention
    J E Castelao
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck University of Southern California School of Medicine, Los Angeles 90033 0800, USA
    Br J Cancer 82:1364-9. 2000
    ..Acetic acids seemed to exhibit the strongest protective effect, whereas aspirin/other salicylic acids and oxicam showed the weakest protection...
  67. pmc Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database
    M J Langman
    Department of Medicine University of Birmingham, Birmingham, B15 2TT
    BMJ 320:1642-6. 2000
    ..To examine whether anti-inflammatory drug treatment protects against the commoner cancers in the United Kingdom...
  68. ncbi Aspirin use and pancreatic cancer mortality in a large United States cohort
    Eric J Jacobs
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329, USA
    J Natl Cancer Inst 96:524-8. 2004
    ..Results from some epidemiologic studies have suggested that aspirin use may reduce risk of pancreatic cancer, but the evidence remains limited...
  69. ncbi Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study
    Marcia Cruz-Correa
    Department of Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 122:641-5. 2002
    ..We evaluated the long-term effectiveness and toxicity of sulindac in attempting to maintain retained rectal segments free of adenomas...
  70. ncbi The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion
    S D Glassman
    Department of Orthopaedic Surgery, University of Louisville School of Medicine, Kentucky, USA
    Spine (Phila Pa 1976) 23:834-8. 1998
    ..The authors recommend that these drugs be avoided in the early postoperative period...
  71. doi Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Gastroenterology 135:1517-25. 2008
    ..Cyclo-oxygenase (COX)-2 selective inhibitors decrease upper GI events, but no prospective trial has prespecified assessment of lower GI clinical events...
  72. pmc ASAS/EULAR recommendations for the management of ankylosing spondylitis
    J Zochling
    Rheumazentrum Ruhrgebiet, St Josefs Krankenhaus, Landgrafenstr 15, 44652 Herne, Germany
    Ann Rheum Dis 65:442-52. 2006
    ..To develop evidence based recommendations for the management of ankylosing spondylitis (AS) as a combined effort of the 'ASsessment in AS' international working group and the European League Against Rheumatism...
  73. ncbi Nonadherence in inflammatory bowel disease: results of factor analysis
    Petr Cerveny
    Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Prague, Czech Republic
    Inflamm Bowel Dis 13:1244-9. 2007
    ..The purpose of the study was to assess overall nonadherence to treatment among patients with Crohn's disease (CD) and ulcerative colitis (UC) in a single tertiary center...
  74. pmc Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
    Patricia M Kearney
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF
    BMJ 332:1302-8. 2006
    ..To assess the effects of selective cyclo-oxygenase-2 (COX 2) inhibitors and traditional non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of vascular events...
  75. ncbi Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study
    Susanne Oksbjerg Dalton
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Arch Intern Med 163:59-64. 2003
    ..Selective serotonin reuptake inhibitors (SSRIs) have been suspected of increasing the risk of bleeding. We examined the risk of upper gastrointestinal tract (GI) bleeding with use of antidepressant medication...
  76. ncbi Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma
    S H Kim
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Clin Exp Allergy 35:585-90. 2005
    ..This study was aimed to evaluate whether genetic variants of TBXA2R may be related with development of acetyl salicylic acid (ASA)-intolerant asthma (AIA)...
  77. doi Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 108:217-31. 2008
    ..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
  78. ncbi Nonsteroidal anti-inflammatory drugs and cancer prevention
    J A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Med 51:511-23. 2000
    ..The mechanisms underlying any chemopreventive effect of NSAIDs are not clear. Inhibition of cyclooxygenase is one possibility, but pathways independent of cyclooxygenase and prostaglandins are also possible...
  79. ncbi Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial
    Karen Toftdahl
    Department of Anesthesiology, Aarhus University Hospital, Denmark
    Acta Orthop 78:172-9. 2007
    ..Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. Recent studies have suggested that periarticular infiltration with local anesthetics may improve outcome...
  80. ncbi Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
    Jean Francois Dhainaut
    Service de Reanimation Medicale, Centre Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    Thromb Haemost 90:642-53. 2003
    ..These latter two effects may occur at the local or cellular level. The systemic biomarkers reported here might not be the most appropriate approach to demonstrate these potential effects of drotrecogin alfa (activated)...
  81. pmc Production of ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 is suppressed by trans-resveratrol in a concentration-dependent manner
    Jean Francois Marier
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, Ste Hyacinthe, Quebec
    Can J Vet Res 69:151-4. 2005
    ..These results support the hypothesis that the immunomodulatory effect of trans-resveratrol plays an important role in disease conditions that involve an overproduction of inflammatory cytokines...
  82. doi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
    ..Pharmacologic therapy with antisecretory drugs may be used in high-risk patients (eg, mechanical ventilation >or=48 hours), although the absolute risk reduction is small, and a decrease in mortality is not documented...
  83. ncbi Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond
    Praveen Rao
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharm Pharm Sci 11:81s-110s. 2008
    ....
  84. ncbi An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease
    A P Sykes
    Biosciences Department, University of Hertfordshire, Hatfield, Hertfordshire, UK
    Inflamm Res 49:311-9. 2000
    ..To determine the effect of nicotine on colonic inflammation in the trinitrobenzenesulphonic acid (TNBS) model of inflammatory bowel disease in comparison with sulphasalazine...
  85. ncbi Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use
    Kam Chuen Lai
    Departments of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    N Engl J Med 346:2033-8. 2002
    ..The role of gastric acid suppression in preventing the recurrence of ulcer complications after the eradication of Helicobacter pylori infection in patients taking long-term low-dose aspirin is uncertain...
  86. ncbi Does ibuprofen increase perioperative blood loss during hip arthroplasty?
    R Slappendel
    St Maartenskliniek, Department of Anaesthesiology, Nijmegen, The Netherlands
    Eur J Anaesthesiol 19:829-31. 2002
    ..To determine whether prior exposure of non-steroidal anti-inflammatory drugs increases perioperative blood loss associated with major orthopaedic surgery...
  87. ncbi R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer
    W J Wechter
    Laboratory of Chemical Endocrinology, Loma Linda University School of Medicine, California 92350, USA
    Cancer Res 57:4316-24. 1997
    ..i.d.. Both drug-treated groups demonstrated tumor numbers significantly less than that of the vehicle control (P < 0.01). Our results suggest that prophylaxis and treatment trials of R-FB should be extended to humans...
  88. ncbi Superiority of lansoprazole vs ranitidine in healing nonsteroidal anti-inflammatory drug-associated gastric ulcers: results of a double-blind, randomized, multicenter study. NSAID-Associated Gastric Ulcer Study Group
    N M Agrawal
    Department of Medicine, University of Connecticut Health Center, Farmington, USA
    Arch Intern Med 160:1455-61. 2000
    ..The usefulness of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by adverse gastrointestinal tract events...
  89. pmc Prostaglandins and cancer
    D Wang
    The Vanderbilt Ingram Cancer Center, Room 698, Preston Research Building, 2300 Pierce Ave, Nashville, Tennessee 37232 6838, USA
    Gut 55:115-22. 2006
    ..Recent efforts to identify the molecular mechanisms by which PGE(2) promotes tumour growth and metastasis may provide opportunities for the development of safer strategies for cancer prevention and treatment...
  90. ncbi Prophylaxis and treatment of non-steroidal anti-inflammatory drug-induced upper gastrointestinal side-effects
    M Lazzaroni
    Gastrointestinal Unit, L. Sacco University Hospital, Milan, Italy
    Dig Liver Dis 33:S44-58. 2001
    ....
  91. ncbi Aspirin and breast cancer prevention: the estrogen connection
    Raymond N DuBois
    JAMA 291:2488-9. 2004
  92. ncbi Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis
    J J Anderson
    Veterans Administration Medical Center, Bedford, Massachusetts, USA
    Arthritis Rheum 44:1876-86. 2001
    ..CONCLUSION: Although further validation using data from new trials is still needed, we conclude that we have developed a clinically valid, easy-to-use measure of short-term improvement in AS...
  93. ncbi A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
    Anne McKay
    Division of Immunology, Infection, and Inflammation, Section of Respiratory Medicine, University of Glasgow, Glasgow, United Kingdom
    J Immunol 172:2903-8. 2004
    ..Simvastatin treatment did not alter serum total IgE or OVA-specific IgG1 and IgG2a levels. These data demonstrate the therapeutic potential of statin-sensitive pathways in allergic airways disease...
  94. ncbi Inflammatory blockade restores adult hippocampal neurogenesis
    Michelle L Monje
    Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Science 302:1760-5. 2003
    ....
  95. pmc Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies
    L A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Br J Clin Pharmacol 52:563-71. 2001
    ..This study summarizes the relative risk (RR) for serious upper gastrointestinal complications (UGIC) associated with aspirin exposure in general and with specific aspirin doses and formulations in particular...
  96. pmc PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]
    Eric J van Breda
    Department of Neurology, University Hospital Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Cardiovasc Disord 2:7. 2002
    ..4 degrees C lower than in the placebo group. The effect of ibuprofen, another potent antipyretic drug, on body-core temperature in normothermic patients has not been studied...
  97. ncbi Aspirin and ovarian cancer: an Italian case-control study
    A Tavani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Ann Oncol 11:1171-3. 2000
    ..A role for inflammation, and consequently of non-steroidal anti-inflammatory drugs, in ovarian carcinogenesis has been proposed, but epidemiological evidence is scanty...
  98. pmc Nonsteroidal antiinflammatory drugs are associated with increased aortic stiffness
    Martin Claridge
    Department of Vascular Surgery, University of Birmingham, Birmingham Heartlands Hospital, UK
    Vasc Health Risk Manag 1:149-53. 2005
    ..The aim of this study was to investigate the effects of NSAIDs on arterial stiffness, a surrogate marker of elastolysis...
  99. ncbi Beyond monotherapy: rational polytherapy in migraine
    S J Peroutka
    Spectra Biomedical, Inc, Burlingame, CA 94010, USA
    Headache 38:18-22. 1998
    ..The rationale for the combination use of dopamine antagonists, anti-inflammatory agents, and 5-HT1 agonists are described in the present report...
  100. ncbi Non-steroidal anti-inflammatory drugs and prostate cancer progression
    A E Norrish
    Department of Community Health, University of Auckland, New Zealand
    Int J Cancer 77:511-5. 1998
    ..These findings lend support to proposed underlying aetiological hypotheses which imply a role for cyclo-oxygenase activity in prostate cancer progression...
  101. ncbi Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US
    Laurel A Habel
    Division of Research, Kaiser Permanente Medical Care Program, Oakland, California 94611, USA
    Cancer Causes Control 13:427-34. 2002
    ..To examine the relationship between daily aspirin use and risk of prostate cancer in a large, racially diverse cohort of men followed for up to 32 years...

Research Grants81

  1. Role of cyclooxygenase-2 in antibody responses to vaccination
    Richard Phipps; Fiscal Year: 2007
    ..Such a finding would improve our ability to respond to routine vaccination, as well as any bioterror threats. ..
  2. Multisite RCT Investigating the Efficacy of Massage in Osteoarthritis
    Adam Perlman; Fiscal Year: 2009
    ....
  3. ETHNIC DISPARITY IN THE USE OF JOINT ARTHROPLASTY
    DENNIS ANG; Fiscal Year: 2007
    ..The Program Director, Munro Peacock, M.D., was appointed in July 1987. The GCRC was ..
  4. ACETAMINOPHEN VS IBUPROFEN ON RENAL FUNCTION DURING EXERCISE
    W Kenney; Fiscal Year: 1999
    ..abstract_text> ..
  5. Novel Sulindac Derivatives for Colon Cancer Chemoprevention
    Robert C Reynolds; Fiscal Year: 2010
    ..This multidisciplinary research proposal may lead to a novel strategy for colon cancer chemoprevention. ..
  6. Cancer Prevention by West African Medicinal Plants
    Michael Wargovich; Fiscal Year: 2007
    ..We have unique access to actual plants with purported anti-inflammatory activity used by actual traditional healers in West Africa. ..
  7. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ....
  8. COX Inhibition & Musculoskeletal Responses to Exercise
    Wendy Kohrt; Fiscal Year: 2007
    ..Therefore, knowledge of whether a drug as widely used as ibuprofen impairs the beneficial adaptations to exercise is deemed to be of high clinical significance. ..
  9. COX Inhibition & Musculoskeletal Responses to Exercise
    Wendy Kohrt; Fiscal Year: 2009
    ..Therefore, knowledge of whether a drug as widely used as ibuprofen impairs the beneficial adaptations to exercise is deemed to be of high clinical significance. ..
  10. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..abstract_text> ..
  11. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  12. Nitric Oxide Chimera Drugs for Colon Cancer Chemoprevention
    GREGORY THATCHER; Fiscal Year: 2009
    ..Aberrant crypt foci (ACF) are seen as an early precursor stage to colon adenomas and cancer in man; and in animal models a good correlation between ACF number and tumorigenesis has been reported. ..
  13. Nitric Oxide Chimera Drugs for Colon Cancer Chemoprevention
    Gregory R J Thatcher; Fiscal Year: 2010
    ..Aberrant crypt foci (ACF) are seen as an early precursor stage to colon adenomas and cancer in man;and in animal models a good correlation between ACF number and tumorigenesis has been reported. ..
  14. Prostaglandins in C. elegans Fertilization
    Michael A Miller; Fiscal Year: 2010
    ..The objective of this proposal is to determine the extent to which the model system Caenorhabditis elegans can be used to elucidate the molecular mechanisms of prostaglandin action during reproduction. ..
  15. Prostaglandins in C. elegans Fertilization
    Michael Miller; Fiscal Year: 2009
    ..The objective of this proposal is to determine the extent to which the model system Caenorhabditis elegans can be used to elucidate the molecular mechanisms of prostaglandin action during reproduction. ..
  16. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004
    ..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..
  17. NO Releasing Aspirin and Colon Cancer Chemoprevention
    Basil Rigas; Fiscal Year: 2003
    ..The long-term goal of these studies is to develop mechanism-driven safe and effective strategies for colon cancer prevention. ..
  18. NO Releasing Aspirin and Colon Cancer Chemoprevention
    Basil Rigas; Fiscal Year: 2005
    ..The long-term goal of these studies is to develop mechanism-driven safe and effective strategies for colon cancer prevention. ..
  19. Type II 11B-Hydroxysteroid Dehydrogenase and Colorectal Tumorigenesis
    Mingzhi Zhang; Fiscal Year: 2010
    ..In the current proposal, we will test whether inhibition of type 2 11ss-hydroxysteroid dehydrogenase activity may provide a new strategy for CRC chemoprevention and chemotherapy with minimal side effects. ..
  20. Type II 11B-Hydroxysteroid Dehydrogenase and Colorectal Tumorigenesis
    Mingzhi Zhang; Fiscal Year: 2009
    ..In the current proposal, we will test whether inhibition of type 2 11ss-hydroxysteroid dehydrogenase activity may provide a new strategy for CRC chemoprevention and chemotherapy with minimal side effects. ..
  21. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2007
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..