oxytocics

..The purpose of this study was to estimate the minimum effective intravenous bolus dose of oxytocin (ED90) required for adequate uterine contraction at elective cesarean in nonlaboring women...

..To compare the effectiveness of oral and vaginal misoprostol for preoperative cervical ripening in premenopausal women before hysteroscopic surgery...

..To assess the effectiveness of oral misoprostol compared with methylergometrine in the prevention of primary post-partum hemorrhage during the third stage of labor...

..Two new interventions are also proposed, the anti-shock garment and the balloon tamponade...

..To determine current clinical practice among different maternity units in the United Kingdom for the management of major postpartum hemorrhage...

..It cannot convert diagnostic hysteroscopy from a hospital procedure into an office one in postmenopausal women with tight cervical os...

..05). CONCLUSIONS: Misoprostol administered vaginally or rectally at a dosage of 400 microg following placental separation was not effective for decreasing postpartum bleeding in women without excessive hemorrhage...

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..Assess the efficacy of one misoprostol tablet (Cytotec) in severe delivery-induced hemorrhage on uterine atony after failure of syntocinon...

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..To evaluate whether routine administration of sublingual misoprostol 600 microg after delivery reduces postpartum haemorrhage...

..Further research in postmenopausal women or those receiving GnRH agonists is also needed, to determine whether misoprostol is effective in cervical ripening in this population...

..The aim of this study was to compare the efficacy and safety of oral misoprostol 400 mug with intramuscular syntometrine in the management of the third stage of labor...

..To characterize the pharmacokinetics and adverse-effect profile of rectally administered misoprostol...

..To compare the efficacy and side effects of vaginal misoprostol with dinoprostone for cervical priming before operative hysteroscopy and to assess the cervicouterine complications related to cervical dilatation and hysteroscopic surgery...

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..Misoprostol results in a shorter interval from induction to delivery. However, Cesarean delivery for a non-reassuring fetal heart rate tracing was more common with misoprostol...

..The objectives of the study were to compare the efficacy and safety of intravaginal misoprostol and intravaginal dinoprostone for induction of labor and to quantify the clinical response to suspicious cardiotocographic (CTG) readings...

..Most studies have not demonstrated a benefit for using misoprostol as a cervical ripening agent in postmenopausal women...

..7, 95% CI 0.5-0.98). CONCLUSIONS: Misoprostol in this dosing regimen is a safe method of labour induction. NICU admission rates were lower in the misoprostol group. No difference could be detected in patient satisfaction between groups...

..Determine safety of household management of postpartum hemorrhage (PPH) with 1000 microg of rectal misoprostol, and assess possible reduction in referrals and the need for additional interventions...

..To compare sublingual misoprostol with intravenous syntometrine use during third stage of labor by measuring the blood loss...

..To review published literature on misoprostol for women's health indications to provide a synthesis of available information and highlight areas in need of additional research...

..To evaluate the effectiveness and possible adverse effects of vaginal misoprostol for cervical priming before hysteroscopy in perimenopausal and postmenopausal women...

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..Oral misoprostol might be used in the management of the third stage, especially in situations where the use of syntometrine is contraindicated and facilities for storage and parenteral administration of oxytocics are limited.

..We aimed to compare efficacy of intravaginal misoprostol versus endocervical laminaria tents prior to operative hysteroscopy in selected cases...

..03). The rate of combined outcome was significantly lower among women receiving misoprostol. However, other indices of obstetric hemorrhage were not significantly different...

..To study the effects of early versus delayed oxytocin augmentation on the obstetrical and neonatal outcome in nulliparous women with spontaneous but prolonged labour...

..To estimate the effects of early augmentation with oxytocin for slow progress of labor on the delivery method and on indicators of maternal and neonatal morbidity...

..To review maternal deaths and the dose-related effects of misoprostol on blood loss and pyrexia in randomized trials of misoprostol use for the prevention or treatment of postpartum haemorrhage...

..To assess and compare the pharmacokinetics and bioavailability of methylergometrine (ME) in men and non-pregnant women...

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..To determine feasibility of community-based distribution of misoprostol for preventing postpartum hemorrhage (PPH) to pregnant woman through community volunteers working under government health services...

..This trial established whether sublingual misoprostol was similarly efficacious to intravenous oxytocin for treatment of post-partum haemorrhage in women not exposed to oxytocin during labour...

..This trial established whether sublingual misoprostol is non-inferior to intravenous oxytocin for treatment of post-partum haemorrhage in women receiving prophylactic oxytocin...

..To investigate the side effects of 600 microg oral misoprostol given for the mother and the newborn to prevent postpartum hemorrhage (PPH)...

..To get a beneficial effect of misoprostol on cervical ripening, estrogenic activity is necessary and when pretreated with local estrogen, misoprostol ameliorates cervical priming in postmenopausal women...

..To systematically review published randomized controlled trials (RCTs) to compare the safety and efficacy of 25 microg versus 50 microg of intravaginal misoprostol for cervical ripening and labor induction...

..To compare the efficacy and safety of induction of labour by vaginal application of dinoprostone or misoprostol or transcervical insertion of a balloon (Bard) catheter...

..To compare the efficacy and side effects of sublingual misoprostol and intravenous methylergometrine for active management of third stage of labor...

..To compare the efficacy and safety of high dose oxytocin in the augmentation of labor...

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..This study aimed to determine the adjunct benefit of misoprostol when combined with standard oxytocics for PPH treatment.

..Conventional oxytocics were given immediately if blood loss was thought to be more than usual. Side-effects were recorded...

..To date, there is very limited evidence for the effectiveness of misoprostol, the lowest effective dose and the magnitude of adverse effects, both direct and indirect. The need for further research is a matter of great urgency...

..u. in 30 mL saline). A trapped placenta may respond to glyceryl trinitrate (500 mcg sublingually) or gentle, persistent, controlled cord traction...

..Current practice guidelines recommend active management of the third stage of labor. We compared practices of three maternity care provider disciplines in management of third-stage labor and the justifications for their approach...

..We did a multicentre, double-blind, randomised controlled trial to determine whether oral misoprostol is as effective as oxytocin during the third stage of labour...

..6%) receiving carbetocin compared to 49 of the women (63.6%) given an IV oxytocin infusion (P <.02). There were no differences in laboratory PPH indicators between the 2 groups...

..In our paper, however, we will focus on oxytocin only, as it is this synthetic hormone that has gained considerable importance in obstetrics. It is used for prevention of PPH as well as for induction of labour...

..In sum, there is no place for the prophylactic use of ME and EM in obstetrics or gynaecology. They can be used for therapeutic purposes in the third stage of labour. During use, the practitioner must be alert for adverse effects...

..There was a pound 1100 saving on direct drug costs in the misoprostol group. CONCLUSIONS: Oral misoprostol (100 microg) has similar efficacy to vaginal PGE2 tablets, and may be an option to consider for term labour induction...

BACKGROUND: Oxytocics are routinely used in an attempt to prevent excessive blood loss during cesarean section...

..This may account for the ability of misoprostol to stimulate the myometrium when administered for cervical ripening...

..MAIN OUTCOME MEASURES: Blood loss during delivery, rate of postpartum haemorrhage, need for repeated oxytocics, haemoglobin level before and 24 hours after delivery, duration of third stage, need for manual removal of ..

..The drug's low cost, ease of administration, stability, and a positive safety profile make it a good option in resource-poor settings...

..To systematically review published data evaluating the comparative use of misoprostol with placebo/expectant management or oxytocin for labor induction in women with term (> or = 36 weeks of gestation) premature rupture of membranes...

..This study was designed in an aim to compare the efficacies of three labor induction methods, dinoprostone (PGE2) vaginal insert with or without concomittant oxytocin and misoprostol (PGE1) combined with oxytocin infusion...

..CONCLUSION: Compared with concentrated oxytocin plus low-dose vaginal misoprostol, high-dose vaginal misoprostol significantly shortens midtrimester labor inductions...

..Women were given a satisfaction questionnaire to complete after delivery. Those who were given misoprostol were satisfied with the outcome, would use it again in the future, and recommend it to friends in similar circumstances...

..It can be concluded that 50 microg of misoprostol applied in the posterior vaginal fornix every 4 hours is an effective dosage for labor induction and has less adverse effects and complications than the 100 microg dose...

..To compare the efficacy and safety of a 25-microgram vaginal tablet of misoprostol (APL202) with dinoprostone (3-mg vaginal tablet) in cervical ripening and labour induction...

..The purpose of this study was to compare the vaginal delivery rate in women who undergo labor induction with preinduction misoprostol or oxytocin alone...

..To compare the efficacy and safety of 100 microg of intravaginal misoprostol with intracervical Foley catheter for cervical ripening and induction of labor...

..The objective of the study was to compare the effectiveness, safety, and side effects of low-dose oral misoprostol with vaginal dinoprostone for cervical ripening and labor induction...

..CONCLUSION: Oral Misoprostol administration was more efficient and cost-effective than PGE2 vaginal pessary for induction of labour due to earlier response with minimal dose and less number of operative deliveries...

..CONCLUSION: Intravaginal misoprostol in a low dose was compared to intracervical balloon catheter for pre-induction ripening of the cervix...

..There was no significant difference in foetal out come in either group. Therefore, it can be concluded that misoprostol is easy to administer and is cheap, effective, safe and convenient drug for induction of labour...

..However, randomized trials to date have found no significant advantage for misoprostol administration compared with other agents for women with PROM...

..The aim of this randomized trial was to compare the efficacy and safety of vaginal misoprostol and oxytocin for cervical ripening and labor induction in patients with premature rupture of membrane (PROM) at term...

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..The aim of the study was to retrospectively identify possible factors for predicting the outcome of induction with misoprostol...

..To compare the safety and efficacy of intravaginal misoprostol to oxytocin for the induction of labor in twin gestations...

..To compare oral misoprostol solution with vaginal prostaglandin gel (dinoprostone) for induction of labour at term to determine whether misoprostol is superior...

..To evaluate complications associated with cervical ripening with vaginal administration of misoprostol and dinoprostone vaginal inserts in women with preeclampsia. preeclampsia...

..To assess the ability of a controlled-release misoprostol vaginal insert to induce labor using dose reservoirs of 25, 50, 100, and 200 microg...

..Misoprostol is a commonly used prostaglandin to induce labour. A potential risk of induction, however, is caesarean delivery, especially in women with an unfavourable cervix...

..To compare outpatient with inpatient misoprostol for preinduction cervical ripening at term...

..To compare the efficacy and safety of intravaginal misoprostol versus dinoprostone cervical gel for cervical ripening and labour induction...

..These results make misoprostol superior to dinoprostone for induction of labour especially in developing and tropical countries...

..Reduced oxytocin requirement was observed when it was added only if needed. Both regimens achieved 85-87% vaginal deliveries with low incidence of hypercontractility...

..To determine whether high-dose (100 microg) misoprostol was able to increase the rate of successful labor induction and lower the incidence of Cesarean section without adverse fetal effects...

..To determine if oral misoprostol can replace oxytocin for labor stimulation in women with ruptured membranes at term and without evidence of labor...

..The higher frequency of uterine hypercontractility associated with the use of misoprostol did not increase the risk of adverse intrapartum and neonatal outcomes...

..To compare the effectiveness of 25 microg vs. 50 microg of intravaginal misoprostol for cervical ripening and labor induction beyond 41 weeks' gestation...

..Pharmacologic agents available for cervical ripening and labor induction include prostaglandins, misoprostol, mifepristone, and relaxin. When the Bishop score is favorable, the preferred pharmacologic agent is oxytocin...

..Side-effects and neonatal complications were similar for the three groups. CONCLUSIONS: Use of extra-amniotic Foley catheter placement showed no measurable benefits over the use of oral misoprostol alone, or vaginal dinoprostone...

..Prospective clinical trials were conducted to assess the safety and efficacy of 6-hourly vaginal misoprostol versus intracervical dinoprostone for induction of labor...

..20.7% of the Cytotec treated patients and 28% of the Oxytocin treated patients required abdominal delivery. CONCLUSIONS: Intravaginal administration of Cytotec appears to be as effective as Oxytocin labor induction...

..Whether misoprostol will prove to be the most cost-effective agent for inducing labor in women with an unfavorable cervix remains to be determined...

..The minimum possible dose of uterotonic drug should be used in induction of labor for multiparous patients to avoid excessive uterine activity, which could increase both maternal and fetal risks...

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..We believe that the data to be gathered from this investigation will support a large, Phase I/ll multi-center trial and an R01 application. ..

..Work in women's health ranges from the molecular and cellular level to the community level; these levels are inter-related. Therefore, UlC's research programs are translational and incorporate multiple levels of analysis. ..

..But it has never been shown to improve the health of women or their babies. This study will begin to fill the knowledge gap that exists between what obstetricians see every day on EFM and how babies are actually doing. ..

..Core B: Clinical Core; Core C: Data Management and Statistics Core; Core D: Information Transfer Core. ..

..This information may serve as a basis for designing new evidence-based therapeutic strategies that can reduce or alleviate severe cardiopulmonary consequences of respiratory disorders. ..

..Examining the process of unwanted change in later life can provide many insights about how people deal with change, the ways they adjust and accommodate it in daily life, and the effects of unwanted change on health and well-being. ..

..The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study resulting in decreased morbidity and mortality. ..

..Stipends are requested to support the entry of two fellows per year for the initial two years and then three fellows per year for up to three years of training. ..

..abstract_text> ..

..If, as we believe, two distinct initiation mechanisms exist, then this would significantly alter how we study each disease process and how we will need to treat them to prevent the progression of the disease. ..

..Abstract Not Provided. ..

..Examining the process of unwanted change in later life can provide many insights about how people deal with change, the ways they adjust and accommodate it in daily life, and the effects of unwanted change on health and well-being. ..

..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..

..The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study resulting in decreased morbidity and mortality. ..

..The goal of this project is to define how Semaphorins signal through Plexin receptors, and to understand the mechanisms by which loss of Plexin receptor expression contributes to melanoma metastasis. ..

..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer & pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..

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..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..

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..When untreated, adolescent-onset BDD appears to often interfere with the developmental tasks of adolescence, to persist, and to cause substantial morbidity through out the life span. ..

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..Data collection will occur in Shanghai; overall project oversight and data analysis will occur in San Francisco, CA. ..

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..The findings from this study could fundamentally change our concepts of matrix enzyme function and the design of intervention approaches to include the effect the mechanical environment has on the ECM. ..

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