oxytocics

Summary

Summary: Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)

Top Publications

  1. ncbi Oxytocin requirements at elective cesarean delivery: a dose-finding study
    Jose C A Carvalho
    Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obstet Gynecol 104:1005-10. 2004
  2. doi Community-based distribution of misoprostol for treatment or prevention of postpartum hemorrhage: cost-effectiveness, mortality, and morbidity reduction analysis
    Tori Sutherland
    Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, USA
    Int J Gynaecol Obstet 108:289-94. 2010
  3. doi Estimation of potential effects of improved community-based drug provision, to augment health-facility strengthening, on maternal mortality due to post-partum haemorrhage and sepsis in sub-Saharan Africa: an equity-effectiveness model
    Christina Pagel
    Clinical Operational Research Unit, Department of Mathematics, University College London, London, UK
    Lancet 374:1441-8. 2009
  4. pmc Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial
    N Mobeen
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan Gynuity Health Projects, New York, NY, USA
    BJOG 118:353-61. 2011
  5. pmc Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment
    Guo Zhang
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Endocrinol Metab 301:E1004-12. 2011
  6. ncbi Complications of labor induction among multiparous women in a community-based hospital system
    Leah Battista
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine, School of Medicine, Orange, USA
    Am J Obstet Gynecol 197:241.e1-7; discussion 322-3, e1-4. 2007
  7. ncbi Prevention of postpartum hemorrhage with misoprostol
    Z Alfirevic
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
    Int J Gynaecol Obstet 99:S198-201. 2007
  8. doi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women receiving prophylactic oxytocin: a double-blind, randomised, non-inferiority trial
    Jennifer Blum
    Gynuity Health Projects, New York, NY 10010, USA
    Lancet 375:217-23. 2010
  9. doi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial
    Beverly Winikoff
    Gynuity Health Projects, New York, NY, USA
    Lancet 375:210-6. 2010
  10. pmc What measured blood loss tells us about postpartum bleeding: a systematic review
    N L Sloan
    Gynuity Health Projects, New York, NY, USA
    BJOG 117:788-800. 2010

Detail Information

Publications211 found, 100 shown here

  1. ncbi Oxytocin requirements at elective cesarean delivery: a dose-finding study
    Jose C A Carvalho
    Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obstet Gynecol 104:1005-10. 2004
    ..The purpose of this study was to estimate the minimum effective intravenous bolus dose of oxytocin (ED90) required for adequate uterine contraction at elective cesarean in nonlaboring women...
  2. doi Community-based distribution of misoprostol for treatment or prevention of postpartum hemorrhage: cost-effectiveness, mortality, and morbidity reduction analysis
    Tori Sutherland
    Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, USA
    Int J Gynaecol Obstet 108:289-94. 2010
    ..To compare the cost-effectiveness of community-based distribution of misoprostol for prevention with misoprostol for treatment of postpartum hemorrhage (PPH)...
  3. doi Estimation of potential effects of improved community-based drug provision, to augment health-facility strengthening, on maternal mortality due to post-partum haemorrhage and sepsis in sub-Saharan Africa: an equity-effectiveness model
    Christina Pagel
    Clinical Operational Research Unit, Department of Mathematics, University College London, London, UK
    Lancet 374:1441-8. 2009
    ....
  4. pmc Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial
    N Mobeen
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan Gynuity Health Projects, New York, NY, USA
    BJOG 118:353-61. 2011
    ..to determine if misoprostol is safe and efficacious in preventing postpartum haemorrhage (PPH) when administered by trained traditional birth attendants (TBA) at home deliveries...
  5. pmc Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment
    Guo Zhang
    Department of Molecular Pharmacology and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Endocrinol Metab 301:E1004-12. 2011
    ..In conclusion, resting-stage oxytocin release and feeding activity represent a critical circadian mechanism and therapeutic target for obesity...
  6. ncbi Complications of labor induction among multiparous women in a community-based hospital system
    Leah Battista
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine, School of Medicine, Orange, USA
    Am J Obstet Gynecol 197:241.e1-7; discussion 322-3, e1-4. 2007
    ..The purpose of this study was to examine complications of labor induction compared to spontaneous labor in multiparas...
  7. ncbi Prevention of postpartum hemorrhage with misoprostol
    Z Alfirevic
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
    Int J Gynaecol Obstet 99:S198-201. 2007
    ..If the initial dose was associated with pyrexia or marked shivering, at least 6 h should lapse before the second dose is given...
  8. doi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women receiving prophylactic oxytocin: a double-blind, randomised, non-inferiority trial
    Jennifer Blum
    Gynuity Health Projects, New York, NY 10010, USA
    Lancet 375:217-23. 2010
    ..This trial established whether sublingual misoprostol is non-inferior to intravenous oxytocin for treatment of post-partum haemorrhage in women receiving prophylactic oxytocin...
  9. doi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial
    Beverly Winikoff
    Gynuity Health Projects, New York, NY, USA
    Lancet 375:210-6. 2010
    ..This trial established whether sublingual misoprostol was similarly efficacious to intravenous oxytocin for treatment of post-partum haemorrhage in women not exposed to oxytocin during labour...
  10. pmc What measured blood loss tells us about postpartum bleeding: a systematic review
    N L Sloan
    Gynuity Health Projects, New York, NY, USA
    BJOG 117:788-800. 2010
    ..Meta-analyses of postpartum blood loss and the effect of uterotonics are biased by visually estimated blood loss...
  11. ncbi Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor
    Rehan Uddin Khan
    Division of Maternal and Fetal Medicine, Imperial College School of Medicine, London, United Kingdom
    Obstet Gynecol 101:968-74. 2003
    ..To characterize the pharmacokinetics and adverse-effect profile of rectally administered misoprostol...
  12. ncbi A randomized trial comparing vaginal misoprostol versus Foley catheter with concurrent oxytocin for labor induction in nulliparous women
    James Culver
    Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Perinatol 21:139-46. 2004
    ..Foley/oxytocin results in a shorter induction-to-vaginal delivery time compared with misoprostol...
  13. doi Prevention of postpartum hemorrhage at home birth in Afghanistan
    Harshadkumar Sanghvi
    JHPIEGO, Baltimore, Maryland, USA
    Int J Gynaecol Obstet 108:276-81. 2010
    ..To test the safety, acceptability, feasibility, and effectiveness of community-based education and distribution of misoprostol for prevention of postpartum hemorrhage at home birth in Afghanistan...
  14. doi Misoprostol for preventing and treating postpartum hemorrhage in the community: a closer look at the evidence
    Olufemi T Oladapo
    Maternal and Fetal Health Research Unit, Department of Obstetrics and Gynecology, Olabisi Onabanjo University Teaching Hospital, P M B 2001, Sagamu, Ogun State, Nigeria
    Int J Gynaecol Obstet 119:105-10. 2012
    ..It is time for the international community to focus on improving PPH-related outcomes by scaling up what is currently guided by hard evidence and join forces to address unanswered questions through high-quality research...
  15. pmc Rethinking WHO guidance: review of evidence for misoprostol use in the prevention of postpartum haemorrhage
    Christina S Chu
    School of Social and Political Science, University of Edinburgh, Edinburgh EH8 9LD, UK
    J R Soc Med 105:336-47. 2012
    ..Current evidence does not support misoprostol use in home and community settings in low- and middle-income countries for PPH prevention. WHO should rethink its recent decision to include misoprostol on the Essential Medicines List...
  16. pmc Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies
    Sarah Arrowsmith
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e36787. 2012
    ..We show that postdates pregnancy is associated with poor myometrial activity and suggest that this may contribute to increased myometrial quiescence and hence, prolonged gestation...
  17. doi Does a novel prefilled injection device make postpartum oxytocin easier to administer? Results from midwives in Vietnam
    Vivien D Tsu
    PATH, 1455 NW Leary Way, Seattle, WA 98107, USA
    Midwifery 25:461-5. 2009
    ....
  18. doi Advance misoprostol distribution for preventing and treating postpartum haemorrhage
    Olufemi T Oladapo
    Maternal and Fetal Health Research Unit, Department of Obstetrics and Gynaecology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria tixon
    Cochrane Database Syst Rev 2:CD009336. 2012
    ..However, the value and safety of this strategy remain contentious...
  19. doi Sublingual misoprostol versus intramuscular oxytocin for prevention of postpartum hemorrhage in low-risk women
    Picklu Chaudhuri
    Department of Obstetrics and Gynecology, Chittaranjan Sevasadan College of Obstetrics and Gynecology and Child Health, Kolkata, India
    Int J Gynaecol Obstet 116:138-42. 2012
    ..To compare sublingual misoprostol with intramuscular oxytocin for prevention of postpartum hemorrhage (PPH) in low-risk vaginal birth...
  20. pmc Care during the third stage of labour: a postal survey of UK midwives and obstetricians
    Diane Farrar
    Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, BD9 6RJ, UK
    BMC Pregnancy Childbirth 10:23. 2010
    ..Evidence to guide care during the third stage is limited and there is variation in recommendations which may contribute to differences in practice. This paper describes current UK practice during the third stage of labour...
  21. doi Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term (PROBAAT trial): an open-label, randomised controlled trial
    Marta Jozwiak
    Groene Hart Hospital, Gouda, Netherlands
    Lancet 378:2095-103. 2011
    ..We aimed to compare the effectiveness and safety of induction of labour with a Foley catheter with induction with vaginal prostaglandin E2 gel...
  22. ncbi [Cervical Foley catheter versus vaginal misoprostol for cervical ripening and induction of labor: a randomized clinical trial]
    Maria Virginia de Oliveira e Oliveira
    Maternidade Escola de Vila Nova Cachoeirinha Dr Mário de Moraes Altenfelder Silva, Sao Paulo, SP, Brasil
    Rev Bras Ginecol Obstet 32:346-51. 2010
    ..To compare the effectiveness of the Foley balloon with vaginal misoprostol for cervical ripening and labor induction...
  23. ncbi Women's perceptions of pain and discomfort after childbirth in Angola
    Elisabeth Jangsten
    Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Afr J Reprod Health 9:148-58. 2005
    Prophylactic treatment against postpartum haemorrhage is a widely investigated area and injection of Oxytocics has been considered as the best choice...
  24. pmc Helping rural women in Pakistan to prevent postpartum hemorrhage: a quasi experimental study
    Ali Mohammad Mir
    Population Council, Islamabad, Pakistan
    BMC Pregnancy Childbirth 12:120. 2012
    ....
  25. doi Induction of labour in nulliparous women with an unfavourable cervix: a randomised controlled trial comparing double and single balloon catheters and PGE2 gel
    C E Pennell
    School of Women s and Infants Health, The University of Western Australia, Crawley, WA, Australia
    BJOG 116:1443-52. 2009
    ..To compare the efficacy and patient satisfaction of three methods of labour induction (double balloon catheters, single balloon catheters and prostaglandin gel) in term nulliparous women with unfavourable cervices...
  26. ncbi Role of protein kinase Cbeta in rhythmic contractions of human pregnant myometrium
    Katsuhiko Yasuda
    Department of Obstetrics and Gynecology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8507, Japan
    Reproduction 133:797-806. 2007
    ..These findings suggest that the increased amplitude of human myometrial contractions during pregnancy is related to the increased level of PKCbeta. A PKCbeta inhibitor may reduce preterm uterine contractions and prevent preterm delivery...
  27. ncbi Cervical ripening before operative hysteroscopy in premenopausal women: a randomized, double-blind, placebo-controlled comparison of vaginal and oral misoprostol
    Cem Batukan
    Department of Obstetrics and Gynecology, School of Medicine, Erciyes University, Kayseri, Turkey
    Fertil Steril 89:966-73. 2008
    ..To compare the effectiveness of oral and vaginal misoprostol for preoperative cervical ripening in premenopausal women before hysteroscopic surgery...
  28. ncbi Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial
    Richard J Derman
    University of Missouri Kansas City School of Medicine, MO, USA
    Lancet 368:1248-53. 2006
    ..We aimed to investigate whether oral misoprostol, a potential alternative to oxytocin, could prevent postpartum haemorrhage in a community home-birth setting...
  29. ncbi A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third stage of labour
    P S Ng
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Hum Reprod 16:31-35. 2001
    ..Oral misoprostol might be used in the management of the third stage, especially in situations where the use of syntometrine is contraindicated and facilities for storage and parenteral administration of oxytocics are limited.
  30. ncbi A randomized, controlled trial comparing effect of oral misoprostol and intravenous syntocinon on intra-operative blood loss during cesarean section
    G Acharya
    Department of Obstetrics and Gynecology, Princess Alexandra Hospital, Harlow, Essex, United Kingdom
    Acta Obstet Gynecol Scand 80:245-50. 2001
    BACKGROUND: Oxytocics are routinely used in an attempt to prevent excessive blood loss during cesarean section...
  31. pmc Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss
    Deirdre J Murphy
    Obstetrics and Gynaecology, Coombe Women and Infants University Hospital, Trinity College Dublin, Dublin 8, Ireland
    BMC Pregnancy Childbirth 9:36. 2009
    ..The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply ..
  32. ncbi Oral, vaginal and sublingual misoprostol for induction of labor
    A Bartusevicius
    Department of Obstetrics and Gynecology, Kaunas University of Medicine, Eiveniu 2, Kaunas 50009, Lithuania
    Int J Gynaecol Obstet 91:2-9. 2005
    ..To evaluate the effectiveness and safety of different administration routes of misoprostol for induction of labor...
  33. doi A randomized controlled trial comparing vaginal misoprostol versus Foley catheter plus oxytocin for labor induction
    Olimpio B Moraes Filho
    Department of Obstetrics and Gynecology, School of Medicine, State University of Pernambuco, Recife, Brazil
    Acta Obstet Gynecol Scand 89:1045-52. 2010
    ..To compare effectiveness and safety of 25 microg vaginal misoprostol versus Foley catheter and oxytocin for cervical ripening and labor induction in pregnant women with unripe cervices...
  34. ncbi The "PRIM" study: a randomized comparison of prostaglandin E2 gel with the nitric oxide donor isosorbide mononitrate for cervical ripening before the induction of labor at term
    Inass Osman
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, United Kingdom
    Am J Obstet Gynecol 194:1012-21. 2006
    ..The purpose of this study was to compare the efficacy and safety profile of prostaglandin E2 with isosorbide mononitrate for cervical ripening before the induction of labor at term...
  35. ncbi History and use of oxytocics
    C E den Hertog
    Department of Obstetrics and Gynaecology, University Hospital Nijmegen, St Radboud, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 94:8-12. 2001
    ..In our paper, however, we will focus on oxytocin only, as it is this synthetic hormone that has gained considerable importance in obstetrics. It is used for prevention of PPH as well as for induction of labour...
  36. ncbi Use of oxytocin to prevent haemorrhage at caesarean section--a survey of practice in the United Kingdom
    Lilantha Wedisinghe
    Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Eur J Obstet Gynecol Reprod Biol 137:27-30. 2008
    ..To establish the views and current practice of obstetricians and anaesthetists with regard to the use of oxytocin to prevent haemorrhage at caesarean section...
  37. doi Five unit bolus oxytocin at cesarean delivery in women at risk of atony: a randomized, double-blind, controlled trial
    Kylie J King
    Department of Anaesthesia, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, New South Wales 2310, Australia
    Anesth Analg 111:1460-6. 2010
    ....
  38. ncbi Sublingual compared with oral and vaginal misoprostol for labor induction
    E M Elhassan
    University of Geizera, Wad Medani, Sudan
    Int J Gynaecol Obstet 97:153-4. 2007
  39. doi Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial
    G Attilakos
    Directorate of Women s and Children s Health, Southmead Hospital, North Bristol NHS Trust, Bristol, UK
    BJOG 117:929-36. 2010
    ..To compare the effectiveness of carbetocin and oxytocin when they are administered after caesarean section for prevention of postpartum haemorrhage (PPH)...
  40. ncbi Oral misoprostol for the prevention of primary post-partum hemorrhage during third stage of labor
    Christopher A Enakpene
    Department of Obstetrics and Gynecology, University College Hospital, Ibadan, Nigeria
    J Obstet Gynaecol Res 33:810-7. 2007
    ..To assess the effectiveness of oral misoprostol compared with methylergometrine in the prevention of primary post-partum hemorrhage during the third stage of labor...
  41. doi An Australian and New Zealand survey of practice of the use of oxytocin at elective caesarean section
    Joanne C Mockler
    Department of Obstetrics and Gynaecology, Monash Institute of Medical Research, Monash University, Australia
    Aust N Z J Obstet Gynaecol 50:30-5. 2010
    ..Overseas studies indicate wide variation in practice with regard to specific doses of oxytocin administered at caesarean section. No such surveys have been undertaken in Australia or New Zealand...
  42. ncbi A double-blind randomized controlled trial of oral misoprostol and intramuscular syntometrine in the management of the third stage of labor
    P S Ng
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, SAR, China
    Gynecol Obstet Invest 63:55-60. 2007
    ..The aim of this study was to compare the efficacy and safety of oral misoprostol 400 mug with intramuscular syntometrine in the management of the third stage of labor...
  43. ncbi Use of misoprostol before hysteroscopy: a systematic review
    Joan M G Crane
    Department of Obstetrics and Gynecology, Memorial University of Newfoundland, St John s NL
    J Obstet Gynaecol Can 28:373-9. 2006
    ..To evaluate the effectiveness of administering misoprostol prior to hysteroscopy in achieving cervical dilatation and reducing complications including cervical laceration...
  44. ncbi Postpartum hemorrhage today: ICM/FIGO initiative 2004-2006
    A Lalonde
    FIGO Safe Motherhood and Newborn Health, The Society of Obstetricians and Gynaecologists of Canada SOGC, Ottawa, ON, Canada
    Int J Gynaecol Obstet 94:243-53. 2006
    ..Two new interventions are also proposed, the anti-shock garment and the balloon tamponade...
  45. ncbi Cervical priming prior to operative hysteroscopy: a randomized comparison of laminaria versus misoprostol
    A M Darwish
    Department of Obstetrics and Gynecology, Assiut University Hospital, Assiut, Egypt
    Hum Reprod 19:2391-4. 2004
    ..We aimed to compare efficacy of intravaginal misoprostol versus endocervical laminaria tents prior to operative hysteroscopy in selected cases...
  46. pmc Misoprostol in addition to routine treatment of postpartum hemorrhage: a hospital-based randomized-controlled trial in Karachi, Pakistan
    Nadeem F Zuberi
    The Aga Khan University, Dept of Obstetrics and Gynecology, Karachi, Pakistan
    BMC Pregnancy Childbirth 8:40. 2008
    ..This study aimed to determine the adjunct benefit of misoprostol when combined with standard oxytocics for PPH treatment.
  47. pmc Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health centre in Guinea-Bissau: randomised double blind clinical trial
    Lars Høj
    Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus N, Denmark
    BMJ 331:723. 2005
    ..To evaluate whether routine administration of sublingual misoprostol 600 microg after delivery reduces postpartum haemorrhage...
  48. ncbi Placebo-controlled randomized comparison of vaginal with rectal misoprostol in the prevention of postpartum hemorrhage
    Okan Ozkaya
    Department of Obstetrics and Gynecology, School of Medicine, Suleyman Demirel University, Isparta, Turkey
    J Obstet Gynaecol Res 31:389-93. 2005
    ..To compare vaginally administered misoprostol to rectally administered misoprostol and placebo in a prospective randomized placebo-controlled study...
  49. ncbi Vaginal misoprostol for cervical priming before hysteroscopy in perimenopausal and postmenopausal women
    E Barcaite
    Department of Obstetrics and Gynecology, Kaunas University of Medicine, Eiveniu 2, Kaunas 50009, Lithuania
    Int J Gynaecol Obstet 91:141-5. 2005
    ..To evaluate the effectiveness and possible adverse effects of vaginal misoprostol for cervical priming before hysteroscopy in perimenopausal and postmenopausal women...
  50. ncbi Priming effect of misoprostol on estrogen pretreated cervix in postmenopausal women
    Rusen Atmaca
    Department of Obstetrics and Gynecology, Inonu University Medical School, Malatya, Turkey
    Tohoku J Exp Med 206:237-41. 2005
    ..To get a beneficial effect of misoprostol on cervical ripening, estrogenic activity is necessary and when pretreated with local estrogen, misoprostol ameliorates cervical priming in postmenopausal women...
  51. ncbi Controlling postpartum hemorrhage after home births in Tanzania
    N Prata
    Bixby Population Program, School of Public Health, University of California, Berkeley, 1213 Tolman Hall, Berkeley, CA 94720 1690, USA
    Int J Gynaecol Obstet 90:51-5. 2005
    ..Determine safety of household management of postpartum hemorrhage (PPH) with 1000 microg of rectal misoprostol, and assess possible reduction in referrals and the need for additional interventions...
  52. ncbi High and low dose oxytocin in augmentation of labor
    A Jamal
    Ob Gyn Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Int J Gynaecol Obstet 87:6-8. 2004
    ..To compare the efficacy and safety of high dose oxytocin in the augmentation of labor...
  53. ncbi Sublingual misoprostol versus methylergometrine for active management of the third stage of labor
    N Vimala
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Int J Gynaecol Obstet 87:1-5. 2004
    ..To compare the efficacy and side effects of sublingual misoprostol and intravenous methylergometrine for active management of third stage of labor...
  54. ncbi A randomized comparison of vaginal misoprostol and dinoprostone for cervical priming in nulliparous women before operative hysteroscopy
    Sangchai Preutthipan
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Fertil Steril 86:990-4. 2006
    ..To compare the efficacy and side effects of vaginal misoprostol with dinoprostone for cervical priming before operative hysteroscopy and to assess the cervicouterine complications related to cervical dilatation and hysteroscopic surgery...
  55. ncbi Reducing postpartum hemorrhage in Vietnam: assessing the effectiveness of active management of third-stage labor
    Vivien D Tsu
    PATH, Seattle, WA 98107, USA
    J Obstet Gynaecol Res 32:489-96. 2006
    ....
  56. doi The effect of early oxytocin augmentation in labor: a meta-analysis
    Shu Qin Wei
    Department of Obstetrics and Gynecology, University of Montreal, 3172 Chemin de la Côte Sainte Catherine, Montreal, Quebec, Canada
    Obstet Gynecol 114:641-9. 2009
    ..To estimate the effects of early augmentation with oxytocin for slow progress of labor on the delivery method and on indicators of maternal and neonatal morbidity...
  57. doi Implementation of guidelines on oxytocin use at caesarean section: a survey of practice in Great Britain and Ireland
    Sharon R Sheehan
    Academic Department of Obstetrics and Gynaecology, Coombe Women and Infants University Hospital and Trinity College, University of Dublin, Dublin 8, Ireland
    Eur J Obstet Gynecol Reprod Biol 148:121-4. 2010
    ....
  58. doi Early versus delayed oxytocin augmentation in nulliparous women with prolonged labour--a randomised controlled trial
    A Dencker
    Department of Obstetrics and Gynecology, Perinatal Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    BJOG 116:530-6. 2009
    ..To study the effects of early versus delayed oxytocin augmentation on the obstetrical and neonatal outcome in nulliparous women with spontaneous but prolonged labour...
  59. pmc Randomized double masked trial of Zhi Byed 11, a Tibetan traditional medicine, versus misoprostol to prevent postpartum hemorrhage in Lhasa, Tibet
    Suellen Miller
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105, USA
    J Midwifery Womens Health 54:133-141.e1. 2009
    ..03). The rate of combined outcome was significantly lower among women receiving misoprostol. However, other indices of obstetric hemorrhage were not significantly different...
  60. doi How do physicians and midwives manage the third stage of labor?
    Weiping M Tan
    Private Practice, Coquitlam, British Columbia, Canada
    Birth 35:220-9. 2008
    ..Current practice guidelines recommend active management of the third stage of labor. We compared practices of three maternity care provider disciplines in management of third-stage labor and the justifications for their approach...
  61. doi The retained placenta
    Andrew D Weeks
    School of Reproductive and Developmental Medicine, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Best Pract Res Clin Obstet Gynaecol 22:1103-17. 2008
    ..u. in 30 mL saline). A trapped placenta may respond to glyceryl trinitrate (500 mcg sublingually) or gentle, persistent, controlled cord traction...
  62. doi Misoprostol for the prevention and treatment of postpartum haemorrhage
    G Justus Hofmeyr
    Effective Care Research Unit, University of the Witwatersrand University of Fort Hare East London Hospital Complex, South Africa
    Best Pract Res Clin Obstet Gynaecol 22:1025-41. 2008
    ..To date, there is very limited evidence for the effectiveness of misoprostol, the lowest effective dose and the magnitude of adverse effects, both direct and indirect. The need for further research is a matter of great urgency...
  63. doi Expanding uterotonic protection following childbirth through community-based distribution of misoprostol: operations research study in Nepal
    Swaraj Rajbhandari
    Options Cambodia
    Int J Gynaecol Obstet 108:282-8. 2010
    ..To determine feasibility of community-based distribution of misoprostol for preventing postpartum hemorrhage (PPH) to pregnant woman through community volunteers working under government health services...
  64. doi A randomised controlled trial of intravaginal dinoprostone, intravaginal misoprostol and transcervical balloon catheter for labour induction
    M Prager
    Division of Obstetrics and Gynaecology, Department of Woman and Child Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    BJOG 115:1443-50. 2008
    ..To compare the efficacy and safety of induction of labour by vaginal application of dinoprostone or misoprostol or transcervical insertion of a balloon (Bard) catheter...
  65. pmc Does self-administered vaginal misoprostol result in cervical ripening in postmenopausal women after 14 days of pre-treatment with estradiol? Trial protocol for a randomised, placebo-controlled sequential trial
    K S Oppegaard
    Department of Gynaecology, Helse Finnmark, Klinikk Hammerfest, Hammerfest, Norway
    BJOG 115:917-e10. 2008
    ....
  66. pmc Comparison of self-administered vaginal misoprostol versus placebo for cervical ripening prior to operative hysteroscopy using a sequential trial design
    K S Oppegaard
    Department of Gynaecology, Helse Finnmark, Klinikk Hammerfest, Hammerfest, Norway
    BJOG 115:663, e1-9. 2008
    ....
  67. ncbi Misoprostol in obstetrics and gynecology
    A Weeks
    University of Liverpool, Liverpool, UK
    Int J Gynaecol Obstet 99:S156-9. 2007
  68. pmc Variations in policies for management of the third stage of labour and the immediate management of postpartum haemorrhage in Europe
    C Winter
    School of Nursing and Midwifery, University of Dundee, Dundee, UK
    BJOG 114:845-54. 2007
    ....
  69. ncbi Comparison of self-administered vaginal misoprostol versus placebo for cervical ripening prior to operative hysteroscopy using a sequential trial design
    K S Oppegaard
    Department of Gynaecology, Helse Finnmark, Klinikk Hammerfest, Hammerfest, Norway
    BJOG 114:769, e1-12. 2007
    ....
  70. doi Side effects of oral misoprostol for the prevention of postpartum hemorrhage: results of a community-based randomised controlled trial in rural India
    Shobhana S Patted
    Department of Obstetrics and Gynecology, Jawaharal Nehru Medical College, Belgaum, India
    J Matern Fetal Neonatal Med 22:24-8. 2009
    ..To investigate the side effects of 600 microg oral misoprostol given for the mother and the newborn to prevent postpartum hemorrhage (PPH)...
  71. ncbi Prevention of postpartum hemorrhage by uterotonic agents: comparison of oxytocin and methylergometrine in the management of the third stage of labor
    Miki Fujimoto
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    Acta Obstet Gynecol Scand 85:1310-4. 2006
    ....
  72. pmc Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects
    G Justus Hofmeyr
    East London Hospital Complex and University of the Witwatersrand, East London, South Africa
    Bull World Health Organ 87:666-77. 2009
    ..To review maternal deaths and the dose-related effects of misoprostol on blood loss and pyrexia in randomized trials of misoprostol use for the prevention or treatment of postpartum haemorrhage...
  73. ncbi A pilot-randomized comparison of sublingual misoprostol with syntometrine on the blood loss in third stage of labor
    H Lam
    Department of Obstetrics and Gynecology, Queen Mary Hospital, Hong Kong SAR, China
    Acta Obstet Gynecol Scand 83:647-50. 2004
    ..To compare sublingual misoprostol with intravenous syntometrine use during third stage of labor by measuring the blood loss...
  74. ncbi Side-effects of oral misoprostol in the third stage of labour--a randomised placebo-controlled trial
    G J Hofmeyr
    Department of Obstetrics and Gynaecology, Coronation Hospital and Effective Care Research Unit, University of the Witwatersrand, Johannesburg
    S Afr Med J 91:432-5. 2001
    ..Conventional oxytocics were given immediately if blood loss was thought to be more than usual. Side-effects were recorded...
  75. ncbi Comparison of the bioavailability and pharmacokinetics of oral methylergometrine in men and women
    A N de Groot
    Department of Obstetrics and Gynaecology, University Hospital Nijmegen, The Netherlands
    Int J Clin Pharmacol Ther 33:328-32. 1995
    ..To assess and compare the pharmacokinetics and bioavailability of methylergometrine (ME) in men and non-pregnant women...
  76. ncbi Labor induction with 25 microg versus 50 microg intravaginal misoprostol: a systematic review
    Luis Sanchez-Ramos
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Florida Health Science Center, Jacksonville, Florida 32209, USA
    Obstet Gynecol 99:145-51. 2002
    ..To systematically review published randomized controlled trials (RCTs) to compare the safety and efficacy of 25 microg versus 50 microg of intravaginal misoprostol for cervical ripening and labor induction...
  77. ncbi A randomised trial comparing low dose vaginal misoprostol and dinoprostone for labour induction
    N van Gemund
    Department of Obstetrics, Leiden University Medical Centre, The Netherlands
    BJOG 111:42-9. 2004
    ..To compare vaginal misoprostol with dinoprostone for induction of labour...
  78. ncbi Misoprostol in gynecology
    Alisa B Goldberg
    Planned Parenthood League of Massachusetts, 1055 Commonwealth Avenue, Boston, MA 02215, USA
    Curr Womens Health Rep 3:475-83. 2003
    ..Most studies have not demonstrated a benefit for using misoprostol as a cervical ripening agent in postmenopausal women...
  79. ncbi Misoprostol for women's health: a review
    Kelly Blanchard
    Population Council, Johannesburg, South Africa
    Obstet Gynecol 99:316-32. 2002
    ..To review published literature on misoprostol for women's health indications to provide a synthesis of available information and highlight areas in need of additional research...
  80. ncbi Management of the third stage of labor: an evidence-based approach
    M C Brucker
    Parkland School of Nurse-Midwifery, Dallas, TX 75235, USA
    J Midwifery Womens Health 46:381-92. 2001
    ....
  81. ncbi Dinoprostone versus misoprostol: a randomized study of nulliparous women undergoing induction of labor
    Amali U Lokugamage
    Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, University College London, London, UK
    Acta Obstet Gynecol Scand 82:133-7. 2003
    ..The objectives of the study were to compare the efficacy and safety of intravaginal misoprostol and intravaginal dinoprostone for induction of labor and to quantify the clinical response to suspicious cardiotocographic (CTG) readings...
  82. ncbi WHO multicentre randomised trial of misoprostol in the management of the third stage of labour
    A M Gulmezoglu
    Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva, Switzerland
    Lancet 358:689-95. 2001
    ..We did a multicentre, double-blind, randomised controlled trial to determine whether oral misoprostol is as effective as oxytocin during the third stage of labour...
  83. ncbi A randomized study comparing rectally administered misoprostol versus Syntometrine combined with an oxytocin infusion for the cessation of primary post partum hemorrhage
    A U Lokugamage
    Department of Obstetrics and Gynaecology, Royal Free and University College London School, Gower Street Campus, 86 96 Chenies Mews, London WC1E 6HX, UK
    Acta Obstet Gynecol Scand 80:835-9. 2001
    ....
  84. ncbi Major postpartum hemorrhage: survey of maternity units in the United Kingdom
    Hatem A Mousa
    University Department of Obstetrics and Gynecology, Liverpool Women s Hospital, UK
    Acta Obstet Gynecol Scand 81:727-30. 2002
    ..To determine current clinical practice among different maternity units in the United Kingdom for the management of major postpartum hemorrhage...
  85. ncbi Randomized controlled trial of vaginal misoprostol versus dinoprostone vaginal insert for labor induction
    D Garry
    Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, New York, USA
    J Matern Fetal Neonatal Med 13:254-9. 2003
    ..To compare the safety and efficacy of vaginal misoprostol versus dinoprostone vaginal inserts for cervical ripening and labor induction...
  86. ncbi [Rectal administration of misoprostol for delivery induced hemorrhage. Preliminary study]
    R Shojai
    Service de Gynécologie Obstétrique Pr L Boubli, CHU Nord, 15, chemin des Bourrelys, 13015 Marseille
    J Gynecol Obstet Biol Reprod (Paris) 30:572-5. 2001
    ..Assess the efficacy of one misoprostol tablet (Cytotec) in severe delivery-induced hemorrhage on uterine atony after failure of syntocinon...
  87. ncbi A randomised placebo-controlled trial of vaginal misoprostol for cervical priming before hysteroscopy in postmenopausal women
    T M Fung
    Obstetrics and Gynaecology Unit, Princess Margaret Hospital, Lai Chi Kok, Hong Kong
    BJOG 109:561-5. 2002
    ..To investigate the effectiveness of misoprostol given vaginally for cervical priming before hysteroscopy in postmenopausal women...
  88. ncbi Ergot alkaloids. Current status and review of clinical pharmacology and therapeutic use compared with other oxytocics in obstetrics and gynaecology
    A N de Groot
    Department of Obstetrics and Gynaecology, University Hospital Nijmegen St Radboud, The Netherlands
    Drugs 56:523-35. 1998
    ..In sum, there is no place for the prophylactic use of ME and EM in obstetrics or gynaecology. They can be used for therapeutic purposes in the third stage of labour. During use, the practitioner must be alert for adverse effects...
  89. ncbi In vitro response of prostaglandin E2 receptor (EP3) in the term pregnant rat uterus and cervix to misoprostol
    Cecilia Lyons
    Division of Perinatal Medicine, Women s Hospital, Long Beach Memorial Medical Center, Long Beach, CA, USA
    Prostaglandins Other Lipid Mediat 70:317-29. 2003
    ..This may account for the ability of misoprostol to stimulate the myometrium when administered for cervical ripening...
  90. ncbi A randomised controlled trial of intramuscular syntometrine and intravenous oxytocin in the management of the third stage of labour
    C M Y Choy
    Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong
    BJOG 109:173-7. 2002
    ..To compare the efficacy and safety of intravenous oxytocin with intramuscular syntometrine in the management of the third stage of labour...
  91. ncbi Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery:a double-blind randomized trial
    Marc Boucher
    Department of Obstetrics and Gynecology, Hopital Sainte Justine, Montreal QC
    J Obstet Gynaecol Can 26:481-8. 2004
    ....
  92. ncbi A randomised comparison of oral misoprostol and vaginal prostaglandin E2 tablets in labour induction at term
    A Shetty
    Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Foresterhill, UK
    BJOG 111:436-40. 2004
    ..To compare the efficacy of 100 microg of oral misoprostol with 3 mg prostaglandin E2 vaginal tablets in term labour induction...
  93. ncbi Misoprostol to treat postpartum haemorrhage: a systematic review
    G Justus Hofmeyr
    Effective Care Research Unit, University of the Witwatersrand University of Fort Hare, East London Hospital Complex, South Africa
    BJOG 112:547-53. 2005
  94. ncbi Misoprostol compared with prostaglandin E2 for labour induction in women at term with intact membranes and unfavourable cervix: a systematic review
    J M G Crane
    Department of Obstetrics and Gynecology, Eastern Health, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    BJOG 113:1366-76. 2006
    ..Misoprostol is a commonly used prostaglandin to induce labour. A potential risk of induction, however, is caesarean delivery, especially in women with an unfavourable cervix...
  95. ncbi [Misoprostol and oxytocin in induction of labour in women with prolonged pregnancy--safety and effectiveness comparison]
    M Wilk

    Wiad Lek 54:662-7. 2001
    ..Mizoprostol administration significantly shortens duration of the first labour period. Eventually, time from the medicine administration until the labour in both groups was comparative...
  96. ncbi Efficacy and safety of six hourly vaginal misoprostol versus intracervical dinoprostone: a randomized controlled trial
    Walid Denguezli
    University Hospital Fattouma Bourguiba, Unit of Obstetrics and Gynaecology, 5000 Monastir, Tunisia
    Arch Gynecol Obstet 276:119-24. 2007
    ..To compare the efficacy and safety of intravaginal misoprostol versus dinoprostone cervical gel for cervical ripening and labour induction...
  97. ncbi A prospective randomized trial of labor induction with vaginal controlled-release dinoprostone inserts with or without oxytocin and misoprostol+oxytocin
    H M Tanir
    Department of Obstetrics and Gynecology, Perinatology Unit, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey
    Clin Exp Obstet Gynecol 35:65-8. 2008
    ..This study was designed in an aim to compare the efficacies of three labor induction methods, dinoprostone (PGE2) vaginal insert with or without concomittant oxytocin and misoprostol (PGE1) combined with oxytocin infusion...
  98. ncbi Labor induction post-term with 25 micrograms vs. 50 micrograms of intravaginal misoprostol
    M M Meydanli
    Department of Obstetrics and Gynecology, Turgut Ozal Medical Centre, School of Medicine, Inonu University, Malatya, Turkey
    Int J Gynaecol Obstet 81:249-55. 2003
    ..To compare the effectiveness of 25 microg vs. 50 microg of intravaginal misoprostol for cervical ripening and labor induction beyond 41 weeks' gestation...
  99. ncbi Oral misoprostol or vaginal dinoprostone for labor induction: a randomized controlled trial
    Patrick Dällenbach
    Department of Obstetrics and Gynecology, Geneva University Hospitals, Geneva, Switzerland
    Am J Obstet Gynecol 188:162-7. 2003
    ..The objective of the study was to compare the effectiveness, safety, and side effects of low-dose oral misoprostol with vaginal dinoprostone for cervical ripening and labor induction...
  100. doi Randomized trial of preinduction cervical ripening: misoprostol vs oxytocin
    Linda Fonseca
    Department of Obstetrics, Gynecology, and Reproductive Sciences, The University of Texas Medical School at Houston, Houston, TX, USA
    Am J Obstet Gynecol 199:305.e1-5. 2008
    ..The purpose of this study was to compare the vaginal delivery rate in women who undergo labor induction with preinduction misoprostol or oxytocin alone...
  101. ncbi Methods for cervical ripening and induction of labor
    Josie L Tenore
    Department of Family Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Am Fam Physician 67:2123-8. 2003
    ..Pharmacologic agents available for cervical ripening and labor induction include prostaglandins, misoprostol, mifepristone, and relaxin. When the Bishop score is favorable, the preferred pharmacologic agent is oxytocin...

Research Grants72

  1. Cranberry for Prevention of Bacteriuria in Pregnancy
    Deborah Wing; Fiscal Year: 2005
    ..We believe that the data to be gathered from this investigation will support a large, Phase I/ll multi-center trial and an R01 application. ..
  2. UIC Program for Interdisciplinary Careers in Women's Health Research
    Stacie Geller; Fiscal Year: 2007
    ..Work in women's health ranges from the molecular and cellular level to the community level; these levels are inter-related. Therefore, UlC's research programs are translational and incorporate multiple levels of analysis. ..
  3. Community Partnership for Breastfeeding Promotion and Support: Creating System Ch
    Ann Dozier; Fiscal Year: 2009
    ..5) Analyze changes in breastfeeding attitudes, experience with breastfeeding promotion and support and breastfeeding outcomes through conducting surveillance across the entire community. ..
  4. Community Partnership for Breastfeeding Promotion and Support: Creating System Ch
    ANN MARIE DOZIER; Fiscal Year: 2010
    ..5) Analyze changes in breastfeeding attitudes, experience with breastfeeding promotion and support and breastfeeding outcomes through conducting surveillance across the entire community. ..
  5. Community Partnership for Breastfeeding Promotion and Support: Creating System Ch
    Ann Dozier; Fiscal Year: 2007
    ..5) Analyze changes in breastfeeding attitudes, experience with breastfeeding promotion and support and breastfeeding outcomes through conducting surveillance across the entire community. ..
  6. Community Partnership for Breastfeeding Promotion and Support: Creating System Ch
    Ann Dozier; Fiscal Year: 2009
    ..5) Analyze changes in breastfeeding attitudes, experience with breastfeeding promotion and support and breastfeeding outcomes through conducting surveillance across the entire community. ..
  7. FLUOXETINE IN PEDIATRIC BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2006
    ..Abstract Not Provided. ..
  8. Non-pneumatic Anti-Shock Garment for Obstetrical Hemorrhage
    Suellen Miller; Fiscal Year: 2009
    ....
  9. Greater New York Autism Research Center of Excellence
    Joseph Buxbaum; Fiscal Year: 2007
    ..Core B: Clinical Core; Core C: Data Management and Statistics Core; Core D: Information Transfer Core. ..
  10. Hypothalamic control of energy expenditure and breathing
    SERDIA MACK; Fiscal Year: 2007
    ..This information may serve as a basis for designing new evidence-based therapeutic strategies that can reduce or alleviate severe cardiopulmonary consequences of respiratory disorders. ..
  11. Age, Disruption, and Life Reorganization after Hurricane Katrina
    Vincanne Adams; Fiscal Year: 2007
    ..Examining the process of unwanted change in later life can provide many insights about how people deal with change, the ways they adjust and accommodate it in daily life, and the effects of unwanted change on health and well-being. ..
  12. Risk factors for medically indicated preterm birth in a Latin American population
    Claudio Sosa; Fiscal Year: 2007
    ..The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study resulting in decreased morbidity and mortality. ..
  13. Training in Psychopharmacology and Outcomes Research
    Ronald Rieder; Fiscal Year: 2007
    ..Stipends are requested to support the entry of two fellows per year for the initial two years and then three fellows per year for up to three years of training. ..
  14. PREDICTING FETAL ACIDEMIA WITH INTRAPARTUM ELECTRONIC FETAL HEART RATE MONITORING
    George A Macones; Fiscal Year: 2010
    ..But it has never been shown to improve the health of women or their babies. This study will begin to fill the knowledge gap that exists between what obstetricians see every day on EFM and how babies are actually doing. ..
  15. Age, Disruption, and Life Reorganization after Hurricane Katrina
    Vincanne Adams; Fiscal Year: 2010
    ..Examining the process of unwanted change in later life can provide many insights about how people deal with change, the ways they adjust and accommodate it in daily life, and the effects of unwanted change on health and well-being. ..
  16. Role of EIIIA fibronectin in pulmonary fibrosis
    Eric S White; Fiscal Year: 2010
    ..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..
  17. Risk factors for medically indicated preterm birth in a Latin American population
    CLAUDIO GERARDO SOSA; Fiscal Year: 2010
    ..The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study resulting in decreased morbidity and mortality. ..
  18. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2010
    ..The goal of this project is to define how Semaphorins signal through Plexin receptors, and to understand the mechanisms by which loss of Plexin receptor expression contributes to melanoma metastasis. ..
  19. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer & pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  20. Role of EIIIA fibronectin in pulmonary fibrosis
    Eric White; Fiscal Year: 2009
    ..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..
  21. Non-pneumatic Anti-Shock Garment for Obstetrical Hemorrhage
    Suellen Miller; Fiscal Year: 2007
    ..abstract_text> ..
  22. TULANE NATIONAL PRIMATE RESEARCH CENTER
    Benjamin Sachs; Fiscal Year: 2007
    ..abstract_text> ..
  23. CARTILAGE CELL AND MATRIX RESPONSE TO JOINT LOADING
    Peter Torzilli; Fiscal Year: 2007
    ..If, as we believe, two distinct initiation mechanisms exist, then this would significantly alter how we study each disease process and how we will need to treat them to prevent the progression of the disease. ..
  24. PHARMACOTHERAPY OF ADOLESCENT BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2002
    ..When untreated, adolescent-onset BDD appears to often interfere with the developmental tasks of adolescence, to persist, and to cause substantial morbidity through out the life span. ..
  25. CARTILAGE CELL AND MATRIX RESPONSE TO JOINT LOADING
    Peter Torzilli; Fiscal Year: 2001
    ....
  26. Divalproex Sodium/Placebo In Child/Adolesent Autism
    Eric Hollander; Fiscal Year: 2003
    ....
  27. Role of Integrins in Pulmonary Fibrosis
    Eric White; Fiscal Year: 2006
    ....
  28. Blood Donation and HIV Prevention in China
    Vincanne Adams; Fiscal Year: 2006
    ..Data collection will occur in Shanghai; overall project oversight and data analysis will occur in San Francisco, CA. ..
  29. Cartilage Degeneration Following Joint Trauma
    Peter Torzilli; Fiscal Year: 2003
    ....
  30. DEFORMATION-DEPENDENT ENZYME CLEAVAGE OF COLLAGEN
    Peter Torzilli; Fiscal Year: 2005
    ..The findings from this study could fundamentally change our concepts of matrix enzyme function and the design of intervention approaches to include the effect the mechanical environment has on the ECM. ..
  31. Estradiol Production by Prostaglandin F2alpha
    Carlos Stocco; Fiscal Year: 2006
    ..abstract_text> ..
  32. Non-pneumatic Anti-Shock Garment for Obstetrical Hemorrhage
    Suellen Miller; Fiscal Year: 2010
    ....