neuromuscular depolarizing agents

Summary

Summary: Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.

Top Publications

  1. ncbi Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
    C Lysakowski
    Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 51:848-57. 2007
  2. ncbi Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid
    A Perez-Gomez
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PEI, Canada
    Neuroscience 208:97-108. 2012
  3. ncbi Acute neurotoxicity of domoic acid in the rat
    L Tryphonas
    Toxicology Research Division, Health and Welfare Canada, Ottawa
    Toxicol Pathol 18:1-9. 1990
  4. ncbi Suspected malignant hyperthermia reactions in New Zealand
    A N Pollock
    Department of Anaesthesia, Palmerston North Hospital, New Zealand
    Anaesth Intensive Care 30:453-61. 2002
  5. ncbi Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy
    Daphne A Gill
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada
    Brain Res 1331:114-23. 2010
  6. pmc Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases
    G Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurochem Int 52:1100-5. 2008
  7. ncbi Domoic acid-induced hippocampal CA1 hyperexcitability independent of region CA3 activity
    P Sari
    Department of Pharmacology, University of Otago School of Medical Sciences, PO Box 913, Dunedin, New Zealand
    Epilepsy Res 47:65-76. 2001
  8. ncbi Rocuronium vs. succinylcholine in the emergency department: a critical appraisal
    William K Mallon
    Department of Emergency Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Emerg Med 37:183-8. 2009
  9. pmc Is succinylcholine appropriate or obsolete in the intensive care unit?
    L H Booij
    Institute for Anaesthesiology, University Hospital Nijmegen, Sint Radboud, Nijmegen, The Netherlands
    Crit Care 5:245-6. 2001
  10. ncbi Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006

Research Grants

Detail Information

Publications200 found, 100 shown here

  1. ncbi Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
    C Lysakowski
    Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 51:848-57. 2007
    ..Propofol-rocuronium is thought to be superior to thiopental-rocuronium for rapid sequence intubation (RSI). The role of the intubation model per se has never been investigated...
  2. ncbi Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid
    A Perez-Gomez
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PEI, Canada
    Neuroscience 208:97-108. 2012
    ....
  3. ncbi Acute neurotoxicity of domoic acid in the rat
    L Tryphonas
    Toxicology Research Division, Health and Welfare Canada, Ottawa
    Toxicol Pathol 18:1-9. 1990
    ..The results of this study suggest that domoic acid is excitotoxic and causes a characteristic syndrome with clinical signs and histopathologic lesions similar to those reported for kainic acid...
  4. ncbi Suspected malignant hyperthermia reactions in New Zealand
    A N Pollock
    Department of Anaesthesia, Palmerston North Hospital, New Zealand
    Anaesth Intensive Care 30:453-61. 2002
    ..This test also demonstrated the shortcomings of the Malignant Hyperthermia Clinical Grading Scale...
  5. ncbi Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy
    Daphne A Gill
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada
    Brain Res 1331:114-23. 2010
    ....
  6. pmc Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases
    G Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurochem Int 52:1100-5. 2008
    ..Inhibitors of p38 (SB203580) and of JNK (SP600125) antagonize DomA-induced apoptosis. These results indicate the importance of oxidative stress-activated JNK and p38 MAP kinase pathways in DomA-induced apoptosis in CGNs...
  7. ncbi Domoic acid-induced hippocampal CA1 hyperexcitability independent of region CA3 activity
    P Sari
    Department of Pharmacology, University of Otago School of Medical Sciences, PO Box 913, Dunedin, New Zealand
    Epilepsy Res 47:65-76. 2001
    ....
  8. ncbi Rocuronium vs. succinylcholine in the emergency department: a critical appraisal
    William K Mallon
    Department of Emergency Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Emerg Med 37:183-8. 2009
    ..Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias...
  9. pmc Is succinylcholine appropriate or obsolete in the intensive care unit?
    L H Booij
    Institute for Anaesthesiology, University Hospital Nijmegen, Sint Radboud, Nijmegen, The Netherlands
    Crit Care 5:245-6. 2001
    ..The adverse effect profile of succinylcholine is such that its use in the ICU must be considered obsolete. Suitable alternatives are the intermediately long-acting nondepolarizing relaxants, of which rocuronium is probably preferable...
  10. ncbi Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006
    ....
  11. ncbi A comparison of succinylcholine and rocuronium for rapid-sequence intubation of emergency department patients
    E G Laurin
    Division of Emergency Medicine, University of California, Davis, Medical Center, University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Emerg Med 7:1362-9. 2000
    ..To compare rocuronium and succinylcholine for rapid-sequence intubation (RSI) in the emergency department (ED)...
  12. ncbi Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 28:673-80. 2006
    ..However, the sublethal persistent neurobehavioral toxicity appears to be less pervasive than reported effects following DA administered mid-gestation...
  13. ncbi Domoic acid neurotoxicity in cultured cerebellar granule neurons is controlled preferentially by the NMDA receptor Ca(2+) influx pathway
    Frederick W Berman
    Department of Physiology and Pharmacology, Rm 2223, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Brain Res 924:20-9. 2002
    ..Neurochem. 71 (1998) 2349], which suggests that elevation of [Ca(2+)](i) in the vicinity of the NMDA receptor ion channel activates processes leading to neuronal death...
  14. ncbi Propofol reduces succinylcholine induced increase of masseter muscle tone
    W C Ummenhofer
    Department of Anaesthesia, University of Basel, Kantonsspital, Switzerland
    Can J Anaesth 45:417-23. 1998
    ....
  15. ncbi Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
    Mathias Sluga
    Department of Anesthesia, Krankenhaus Thusis, Switzerland
    Anesth Analg 101:1356-61. 2005
    ..We conclude that during rapid sequence induction of anesthesia in emergent cases, succinylcholine allows for a more rapid endotracheal intubation sequence and creates superior intubation conditions compared with rocuronium...
  16. ncbi Acute parenteral neurotoxicity of domoic acid in cynomolgus monkeys (M. fascicularis)
    L Tryphonas
    Toxicology Research Division, Health Protection Branch, Health and Welfare Canada, Ottawa
    Toxicol Pathol 18:297-303. 1990
    ..It was concluded that D.A., administered intravenously, is neuroexcitatory and a powerful emetic at doses of 0.025 to 0.2 mg/kg. At higher doses (0.5 mg/kg intravenously and 4 mg/kg intraperitoneally), D.A. is strongly excitotoxic...
  17. pmc Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial
    Stephan C Marsch
    Department of Medical Intensive Care, University Hospital Basel, University of Basel, Petersgraben 4, Basel 4031, Switzerland
    Crit Care 15:R199. 2011
    ..Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI...
  18. ncbi [Neuromuscular blockades. Agents, monitoring and antagonism]
    J U Schreiber
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar
    Anaesthesist 55:1225-35; quiz 1236. 2006
    ..Therefore, the monitoring of neuromuscular recovery plays an important role in the prevention of postoperative complications due to residual paralysis. In case of residual paralysis, cholinesterase inhibitors are suitable for reversal...
  19. ncbi Anesthetic management for two infants undergoing surgery for tension pneumatoceles
    Chih Min Liu
    Paediatr Anaesth 17:189-90. 2007
  20. ncbi The effect of isoflurane 0.6% on respiratory mechanics in anesthetized-paralyzed humans is not increased at concentrations of 0.9% and 1.2%
    Pedro Ruiz
    Department of Anesthesia, McGill University, Montreal, Quebec, Canada
    Can J Anaesth 50:67-70. 2003
    ..To assess the dose-dependent effect of low concentrations of isoflurane on respiratory mechanics in normal subjects...
  21. ncbi Can lidocaine reduce succinylcholine induced postoperative myalgia?
    Somchai Amornyotin
    Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Med Assoc Thai 85:S969-74. 2002
    ..In conclusion, where succinylcholine is used, lidocaine is proven to be the useful pretreatment agent for the reduction of postoperative myalgia...
  22. ncbi A comparison of intubating conditions in children following induction of anaesthesia with propofol and suxamethonium or propofol and remifentanil
    J M Morgan
    Department of Anaesthesia, Sheffield Children s Hospital, Western Bank, Sheffield S10 2TH, UK
    Anaesthesia 62:135-9. 2007
    ..05). Mean apnoea time was 190 s in group S, and 362 s in group R (p<0.001). Heart rate increased in response to suxamethonium (p<0.01) and both systolic and diastolic blood pressure decreased in the remifentanil group (p<0.01)...
  23. ncbi The dose of succinylcholine in morbid obesity
    Harry J M Lemmens
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 102:438-42. 2006
    ..Our study demonstrates that for complete neuromuscular paralysis and predictable laryngoscopy conditions, SCH 1 mg/kg total body weight is recommended...
  24. ncbi Rocuronium versus succinylcholine for rapid tracheal intubation
    Aaron F Kopman
    Anesth Analg 102:1912; author reply 1912-3. 2006
  25. ncbi Are intubation conditions using rocuronium equivalent to those using succinylcholine?
    Jeffrey Joseph Perry
    Division of Emergency Medicine, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Acad Emerg Med 9:813-23. 2002
    ..To determine whether the intubation conditions created by rocuronium are equivalent to those of succinylcholine during rapid-sequence induction (RSI)...
  26. ncbi Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions
    O Karcioglu
    Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey
    Int J Clin Pract 60:1638-46. 2006
    ..1% increase (95% CI = 13.7-24.5) in the frequency of excellent ETI conditions. SCH appears to be superior to RCR in creating excellent ETI conditions and avoiding unacceptable ETI conditions...
  27. ncbi Lidocaine or diazepam can decrease fasciculation induced by succinylcholine during induction of anesthesia
    Mansour Hassani
    Tehran University of Medical Sciences, Hassan Abad Square, Sina Hospital, Tehran, Iran
    Middle East J Anaesthesiol 18:929-31. 2006
    ..There is no significant difference between these two drugs in reducing fasciculations moreover, these drugs can also prevent raised blood pressure and heart rate during intubation...
  28. ncbi Which muscle relaxants should be used in day surgery and when
    Gabriella Bettelli
    Department of Anaesthesia and Intensive Care, University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy
    Curr Opin Anaesthesiol 19:600-5. 2006
    ..Agent selection criteria are discussed...
  29. ncbi Rocuronium in emergent intubation
    C Chamorro
    Anesth Analg 103:253-4. 2006
  30. ncbi Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction
    S Sakuraba
    Department of Anesthesiology, School of Medicine, Keio University, Tokyo, Japan
    Acta Anaesthesiol Belg 57:253-7. 2006
    ....
  31. ncbi Rocuronium combined with i.v. lidocaine for rapid tracheal intubation
    D Yorukoglu
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Ankara, Ankara, Turkey
    Acta Anaesthesiol Scand 47:583-7. 2003
    ..We compared the intubating conditions and hemodynamic changes after the administration of rocuronium 0.6 mg kg(-1) and lidocaine 1.5 mg kg(-1) with rocuronium alone and succinylcholine 60 and 90 s after administration...
  32. ncbi Effect of ephedrine on the onset time of succinylcholine
    S Ganidagli
    Department of Anaesthesiology and Reanimation, Harran University Medical School, Sanliurfa, Turkey
    Acta Anaesthesiol Scand 48:1306-9. 2004
    ..The aim of this study was to evaluate the effect of ephedrine administered prior to induction of anaesthesia on the onset time of succinylcholine for endotracheal intubation...
  33. ncbi Anesthesia for removal of inhaled foreign bodies in children
    Amit Soodan
    Department of Anaesthesiology, All India Institute of Medical Sciences, New Delhi, India
    Paediatr Anaesth 14:947-52. 2004
    ..This prospective randomized clinical trial was undertaken to compare spontaneous and controlled ventilation during anesthesia for removal of inhaled foreign bodies in children...
  34. ncbi Anesthesia in Beckwith-Wiedemann syndrome
    V Celiker
    Department of Anaesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 14:778-80. 2004
    ..We did not have difficulty in airway management either with tracheal intubation or rigid bronchoscopy, but we could not extubate the baby because of tracheomalacia...
  35. ncbi Propofol relieves post-extubation laryngospasm in obstetric anesthesia
    Vincenzo Fodale
    Int J Obstet Anesth 13:196-7. 2004
  36. ncbi Controversies in rapid sequence intubation in children
    Audrey Zelicof-Paul
    Department of Pediatrics, Emergency Division, The Children s Hospital of New York Presbyterian, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Pediatr 17:355-62. 2005
    ..The purpose of the present review is to address several controversies pertaining to emergency department rapid sequence intubation of children...
  37. ncbi Trauma in pregnancy: anesthetic management of a parturient with hypotensive shock and trauma to the gravid uterus
    T W Nelson
    Acta Anaesthesiol Scand 48:662. 2004
  38. ncbi Traumatic asphyxia: a case report and anesthetic implications
    Mazen Elias
    Pain Management Clinic, 704 S Webster Ave, Green Bay Wisconsin, WI 54301, USA
    Middle East J Anesthesiol 17:455-62. 2003
  39. ncbi Tracheal intubating conditions and apnoea time after small-dose succinylcholine are not modified by the choice of induction agent
    M I El-Orbany
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA
    Br J Anaesth 95:710-4. 2005
    ..v. induction drugs on tracheal intubation conditions and apnoea time after small-dose (0.6 mg kg(-1)) succinylcholine used to facilitate orotracheal intubation at an urban, university-affiliated community medical centre...
  40. ncbi Treatment of sarin exposure
    Peter DeBalli
    JAMA 291:181-2; author reply 182-3. 2004
  41. ncbi Use of remifentanil for tracheal intubation for caesarean section in a patient with suxamethonium apnoea
    R Alexander
    Department of Anaesthetics, Worcestershire Royal Hospital, Charles Hastings Way, Worcester WR5 1DD, UK
    Anaesthesia 60:1036-8. 2005
    ..The parturient awoke following an uneventful caesarean section with excellent pain relief and no recall. The baby had normal Apgar scores and umbilical blood gas measurements...
  42. ncbi The Combitube as a salvage airway device for paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, CA 92103 8676, USA
    Ann Emerg Med 42:697-704. 2003
    ..Here we describe our experience with the Combitube (esophageal-tracheal twin-lumen airway device) as a salvage airway device for paramedic rapid sequence intubation...
  43. ncbi Hyperkalemia and pyloric stenosis
    Donald Schwartz
    Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts 01199, USA
    Anesth Analg 97:355-7, table of contents. 2003
    ..Thirty-six percent of patients with pyloric stenosis had increased serum potassium levels. We conclude that hyperkalemia may be more common in children with pyloric stenosis than previously thought...
  44. ncbi [Application of muscle relaxants for rapid-sequence induction of anaesthesia]
    R Hofmockel
    Klinik für Anästhesiologie und Intensivtherapie, Universitat Rostock
    Anaesthesist 52:516-21. 2003
    ..It is the opinion of the authors that timing but also drugs with a slow onset (e.g., alcuronium and Pancuronium) are obsolete in the context of RSI...
  45. ncbi [Frequency distribution of dibucaine numbers in 24,830 patients]
    G Pestel
    Institut für Anaesthesiologie und Intensivmedizin, Leopoldina Krankenhaus, Schweinfurt
    Anaesthesist 52:495-9. 2003
    ..Measuring the dibucaine number identifies patients who are at risk. This study shows the frequency distribution of dibucaine numbers routinely measured and discusses avoidable clinical problems and economic implications...
  46. ncbi General anesthesia with remifentanil for Cesarean section in a patient with HELLP syndrome
    F Richa
    Department of Anesthesia and Intensive Care, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon
    Acta Anaesthesiol Scand 49:418-20. 2005
    ..We report the management of a patient presenting in labor with HELLP syndrome, and describe the successful use of remifentanil as part of the anesthetic technique for her subsequent Cesarean section...
  47. ncbi Prehospital rapid-sequence intubation: a pilot training program
    Kory Kaye
    Region Hospital EMS, St Paul, Minnesota, USA
    Prehosp Emerg Care 7:235-40. 2003
    ..To develop a training program enabling paramedics to use sedation and paralytic medications to facilitate endotracheal intubation in patients who otherwise could not be successfully intubated...
  48. ncbi Succinylcholine vs rocuronium for intubation in the intensive care unit
    Kathryn Regan
    National Hospital for Neurology and Neurosurgery, London WC1N 3BG
    Br J Hosp Med (Lond) 66:548. 2005
  49. ncbi Suxamethonium administration prolongs the duration of action of subsequent rocuronium
    E N Robertson
    University Medical Center, Department of Anesthesiology, Nijmegen, The Netherlands
    Eur J Anaesthesiol 21:734-7. 2004
    ..The neuromuscular effects of suxamethonium and rocuronium, and their effects on intraocular pressure (IOP), heart rate (HR) and arterial pressure were also recorded...
  50. ncbi Morbid obesity: a risk factor for maternal mortality
    Olubukola Nafiu
    Int J Obstet Anesth 16:187; author reply 187-8. 2007
  51. ncbi Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium
    J R Ortiz-Gómez
    University Clinic, Department of Anesthesiology and Intensive Care, Navarra, Spain
    Eur J Anaesthesiol 22:263-8. 2005
    ..To evaluate orotracheal intubation conditions after 1 min...
  52. ncbi Effectiveness of continuous positive airway pressure to enhance pre-oxygenation in morbidly obese women
    D M Cressey
    Anaesthesia, Surgical and Anaesthetic Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Anaesthesia 56:680-4. 2001
    ..A brief period of lower mean heart rate in the CPAP group was the only statistically significant difference in cardiovascular parameters. There was no significant difference in the volume of gastric gas after induction between groups...
  53. ncbi Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia
    Mona R Gätke
    Danish Cholinesterase Research Unit, Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Pharmacogenet Genomics 17:995-9. 2007
    ..We present three novel mutations in the butyrylcholinesterase gene (BCHE) identified in three families in which a member had experienced severely prolonged duration of action of succinylcholine...
  54. ncbi Modification of mediators of immune reaction after general anaesthesia
    A Sanchez Palacios
    Unidad de Alergologia, Hospital Universitario Insular de G C Las Palmas, Gran Canaria, Spain
    Allergol Immunopathol (Madr) 32:352-60. 2004
    ....
  55. ncbi [Anesthesia for electroconvulsive therapy: clinical experience]
    A G Gonzalez
    Departamento de Anestesiologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Esp Anestesiol Reanim 54:414-20. 2007
    ..To assess the utility of propofol and succinylcholine in obtaining optimal convulsions and assuring patient safety during electroconvulsive therapy...
  56. ncbi [Does rocuronium displace the position of suxamethonium?]
    Tomoki Sasakawa
    Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Asahikawa 078 8510
    Masui 57:860-8. 2008
    ..Once Org 25969 (sugammadex) is available to rapidly bind rocuronium and reverse its action, rocuronium may replace succinylcholine for rapid-sequence induction...
  57. ncbi The effects of magnesium sulphate-pretreatment on suxamethonium-induced complications during induction of general endotracheal anaesthesia
    K Y Danladi
    Department of Anaesthesia, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
    Afr J Med Med Sci 36:43-7. 2007
    ..The average of 0.034 mmol/L in Group B was not significant {p value 0.06}. We advocate the use of magnesium pretreatment in all patients at risk of these complications...
  58. ncbi Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers
    Paul Michel Mertes
    Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
    Anesthesiology 107:245-52. 2007
    ..Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs)...
  59. ncbi Anaesthesia for caesarean section in a patient with acute generalised pustular psoriasis
    A Samieh-Tucker
    Department of Anaesthesia, Basildon University Hospital, Basildon, Essex, UK
    Int J Obstet Anesth 16:375-8. 2007
    ..The purpose of this article is to delineate the clinical picture of this disease, its treatment, and the effect on the mother and the fetus...
  60. ncbi Altered response to intravenous thiopental and succinylcholine in acute amphetamine abuse
    O Stibolt
    Department M, Copenhagen Hospital Corporation, Sct Hans Hospital, Roskilde, Denmark
    Acta Anaesthesiol Scand 46:609-10. 2002
    ..Amphetamine is a strong sympathomimetic and may therefore influence the course of anesthesia. We report the case of a patient with acute amphetamine abuse presenting difficulties during anesthesia...
  61. ncbi Intraocular pressure changes after succinylcholine and endotracheal intubation: a comparison of thiopental and propofol on IOP
    M B Khosravi
    Indian J Ophthalmol 55:164. 2007
  62. ncbi Anesthetic implications of botulinum toxin type A (Botox) injections for the treatment of 'the aging face' in the parturient
    K M Kuczkowski
    Acta Anaesthesiol Scand 51:515-6. 2007
  63. ncbi [Electroconvulsive therapy in the third trimester of pregnancy: a case report]
    R M Prieto Martin
    Servicio de Anestesiologia y Reanimacion, Hospital Universitario de Salamanca
    Rev Esp Anestesiol Reanim 53:653-6. 2006
    ..The patient experienced clear improvement and 2 days after the last treatment spontaneous labor commenced. A healthy boy was born by vaginal delivery...
  64. ncbi Posterior reversible encephalopathy syndrome during pregnancy: seizures in a previously healthy parturient
    Timothy R Long
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Anesth 19:145-8. 2007
    ..Prompt recognition and treatment of this potentially catastrophic disease may avert injury to the patient and neonate...
  65. ncbi Pretreatment before succinylcholine for outpatient anesthesia?
    Thomas Mencke
    Department of Anesthesia and Critical Care Medicine, University of the Saarland, Saar, Germany
    Anesth Analg 94:573-6; table of contents. 2002
    ..However, in most patients, pretreatment was associated with muscle weakness before loss of consciousness. Thus, there is no convincing evidence supporting routine pretreatment with succinylcholine...
  66. ncbi Anaphylaxis during surgical and interventional procedures
    Bernard Yu Hor Thong
    Department of Rheumatology, Allergy, and Immunology, Tan Tock Seng Hospital, Singapore
    Ann Allergy Asthma Immunol 92:619-28. 2004
    ..To describe the current evidence-based knowledge of the causes, diagnostic evaluation, and treatment of patients with anaphylaxis associated with surgical and interventional procedures...
  67. ncbi Cell death of motoneurons in the chick embryo spinal cord. XI. Acetylcholine receptors and synaptogenesis in skeletal muscle following the reduction of motoneuron death by neuromuscular blockade
    R W Oppenheim
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27103
    Development 107:331-41. 1989
    ..These receptor changes very likely reflect increased synaptogenesis in the muscles of paralyzed embryos which in turn may act to reduce motoneuron death by providing increased access to muscle-derived neurotrophic molecules...
  68. ncbi In vivo reversal of depolarizing neuromuscular blockade
    W F Riker
    Department of Anesthesiology and Pharmacology, New York Hospital Cornell Medical Center, New York, NY 10021, USA
    Arch Int Pharmacodyn Ther 330:90-101. 1995
    ..Tetraethyl- and tetrabutylammonium ions proved to be effective antagonists of succinylcholine block following inactivation of plasma cholinesterases by hexafluorenium...
  69. ncbi An observation study of rapid sequence, awake and sedation-only intubations in an emergency department in Thai patients
    Satariya Trakulsrichai
    Emergency Department, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 92:1022-7. 2009
    ..The observation of RSI and two former methods in EDs were carried out to assess whether RSI was more successful and had lower immediate complication in Thai patients or not...
  70. ncbi Effect of landiolol hydrochloride on suxamethonium-induced neuromuscular block
    Takahiro Suzuki
    Department of Anesthesiology, Surugadai Nihon University Hospital, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8309, Japan
    J Anesth 23:188-91. 2009
    ..The aim of this study was to examine the effect of landiolol hydrochloride, an ultrashort-acting beta(1)-blocker, on suxamethonium-induced neuromuscular block...
  71. ncbi Sore throat following tracheal intubation
    R Kloub
    Watford General Hospital, Vicarage Road, Watford, Herts, WDI 8HB, United Kingdom
    Middle East J Anesthesiol 16:29-40. 2001
    ..Nasogastric tube insertion was associated with a significantly increased incidence of sore throat (p < 0.01)...
  72. ncbi [Legal liability problems in outpatient operations. View from an anesthesiological perspective]
    K Ulsenheimer
    Anaesthesist 61:156-62. 2012
    ..Particularly prone to liability problems are the postoperative phase and discharge of patients which will be demonstrated in some exemplary cases...
  73. ncbi Comparison of succinylcholine and rocuronium for first-attempt intubation success in the emergency department
    Asad E Patanwala
    Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, AZ, USA
    Acad Emerg Med 18:10-4. 2011
    ..The objective was to determine the effect of paralytic type and dose on first-attempt rapid sequence intubation (RSI) success in the emergency department (ED)...
  74. ncbi Role of extraocular pressure in open globe injury
    James R Brinkley
    Anesthesiology 100:1036; author reply 1037. 2004
  75. ncbi GABAB autoreceptors in rat cortex synaptosomes: response under different depolarizing and ionic conditions
    G Bonanno
    Istituto di Farmacologia e Farmacognosia, Universita degli Studi di Genova, Italy
    Eur J Pharmacol 172:41-9. 1989
    ..The data support the idea that terminal GABA autoreceptors in the rat cerebral cortex are of the GABAB type...
  76. ncbi Structure-activity relationships of aromadendranes in uterus-relaxant activity
    Nury Perez-Hernandez
    Escuela de Medicina, Universidad Autonoma del Estado de Hidalgo, Eliseo Ramirez Ullua 400, Col Doctores, Pachuca, Hidalgo, 42001, Mexico
    Z Naturforsch C 64:840-6. 2009
    ....
  77. ncbi Effects of rocuronium pretreatment on muscle enzyme levels following suxamethonium
    Onur Ozlu
    Department of Anaesthesiology, Social Security Ankara Children Hospital, Ankara, Turkey
    Paediatr Anaesth 12:151-5. 2002
    ..The effects of different time intervals between rocuronium pretreatment and suxamethonium administration on muscle-derived enzymes and myoglobin were evaluated...
  78. ncbi Early postoperative vomiting and volatile anaesthetics or nitrous oxide
    G Verheecke
    Br J Anaesth 90:109; author reply 109-10. 2003
  79. ncbi Giant multimodal heart motoneurons of Achatina fulica: a new cardioregulatory input in pulmonates
    V Zhuravlev
    Department of General Physiology, Saint Petersburg University, 199034 Saint Petersburg, Russia
    Comp Biochem Physiol A Mol Integr Physiol 130:183-96. 2001
    ..New giant heart motoneurons do not interact with previously identified cardioregulatory neurons...
  80. ncbi Do you know about donepezil and succinylcholine?
    C Walker
    Anaesthesia 57:1041. 2002
  81. ncbi Goodbye suxamethonium!
    C Lee
    Department of Anesthesiology, Harbor UCLA Medical Center, Torrance, CA, USA
    Anaesthesia 64:73-81. 2009
    ..With the arrival of sugammadex, it finally appears that suxamethonium can be retired. Suxamethonium has done its job and seen its days! The present review is intended to offer a eulogy for suxamethonium...
  82. ncbi Which port in a storm? Use of suxamethonium without intravenous access for severe laryngospasm
    Robert W M Walker
    Anaesthesia 62:757-9. 2007
  83. ncbi Effect of paralytic type on time to post-intubation sedative use in the emergency department
    John M Watt
    Department of Surgery College of Medicine, University of Arizona Tucson, Arizona, USA
    Emerg Med J 30:893-5. 2013
    ..To determine the difference between rocuronium and succinylcholine with regard to post-intubation sedative initiation in the emergency department...
  84. ncbi Muscular chanellopathies and hypermetabolic reactions
    F Veyckemans
    Acta Anaesthesiol Scand 49:124-5; author reply 125. 2005
  85. ncbi [Muscle relaxants and neuromuscular monitoring - Introduction for a safe clinical application]
    Dennis Döcker
    Standort Katharinenhospital
    Anasthesiol Intensivmed Notfallmed Schmerzther 47:296-305; quiz 306. 2012
    ..This article gives a review of the basic principles of muscle relaxants, their clinical application and the surveillance of their effects and degradation...
  86. ncbi Subclinical effects of saxitoxin and domoic acid on aggressive behaviour and monoaminergic turnover in rainbow trout (Oncorhynchus mykiss)
    Marit Jørgensen Bakke
    Department of Pharmacology and Toxicology, Norwegian School of Veterinary Science, N 0033 Oslo, Norway
    Aquat Toxicol 99:1-9. 2010
    ..This could indicate that the toxins mediate aggressive behaviour either through other systems than the monoaminergic systems, such as neuroactive amino acids, or that the mediation occurs in other brain regions...
  87. ncbi Lethal adverse reaction during anaesthetic induction
    S Fernandez-Galinski
    Eur J Anaesthesiol 23:81-2. 2006
  88. ncbi How much are patients willing to pay to avoid postoperative muscle pain associated with succinylcholine?
    Terrence K Allen
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Clin Anesth 19:601-8. 2007
    ..To determine how much money patients are willing to pay to avoid postoperative muscle pains associated with succinylcholine...
  89. ncbi Complete atrioventricular block following etomidate
    A Combeer
    Eur J Anaesthesiol 24:1067-8. 2007
  90. ncbi Onset of succinylcholine neuromuscular block--in vivo versus in vitro
    Anis Baraka
    Department of Anesthesiology, American University of Beirut, PO Box 11 0236, Beirut, 1107 2020, Lebanon
    Middle East J Anesthesiol 16:477-84. 2002
  91. ncbi Unusual effect of suxamethonium
    J Gibson
    Anaesth Intensive Care 32:290. 2004
  92. ncbi [Basic and clinical importance of nicotinic acetylcholine receptors]
    Takahiro Suzuki
    Department of Anesthesiology, Surugadai Nihon University Hospital, Tokyo 101 8309
    Masui 57:813-8. 2008
    ..Importantly in clinical settings, the immature nAChR is resistant to non-depolarizing neuromuscular blocking agents and more sensitive to depolarizing muscle relaxants...
  93. ncbi [Muscle relaxants in ambulatory anesthesia]
    Junzo Takeda
    Department of Anesthesiology, School of Medicine, Keio University, Tokyo 160 8582
    Masui 57:845-52. 2008
    ..Sugammadex will resolve many issues in using nondepolarizing neuromuscular agents in ambulatory anesthesia...
  94. ncbi A fully validated isotope dilution HPLC-MS/MS method for the simultaneous determination of succinylcholine and succinylmonocholine in serum and urine samples
    Uta Kuepper
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Mass Spectrom 43:1344-52. 2008
    ..5 and 4.9 ng/ml (SMC).The presented method was successfully applied to authentic samples of two forensic cases investigated in the institute of forensic medicine in Bonn, allowing the diagnosis of SUX intoxications...
  95. ncbi Depolarization-induced release of ethanolamine from brain synaptic preparations in vitro
    Chengyong Liao
    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada
    Brain Res 1060:170-8. 2005
    ..The present results add support to the concept that ethanolamine may play a role as a synaptic signaling molecule in mammalian brain...
  96. ncbi The continuing search for a succinylcholine replacement
    James E Caldwell
    Anesthesiology 100:763-4. 2004
  97. pmc The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 112:282-8. 1994
    ....
  98. ncbi Sedation and paralysis during mechanical ventilation
    William E Hurford
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Respir Care 47:334-46; discussion 346-7. 2002
    ..Advantages, adverse effects, and limitations of drug treatment, including use of neuromuscular blocking drugs and use of sedatives and analgesia during the withdrawal of life-sustaining measures are reviewed...
  99. ncbi Fresh frozen plasma for succinylcholine apnoea
    C C Harle
    Anaesthesia 59:89; author reply 89-90. 2004
  100. ncbi No response to trigger agents in a malignant hyperthermia-susceptible patient
    B A Claxton
    Department of Anaesthesia, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Br J Anaesth 88:870-3. 2002
    ..Absence of a reaction to trigger agents on this occasion is not thought to indicate an incorrect diagnosis and labelling...
  101. ncbi Electroencephalographic, behavioral, and c-fos responses to acute domoic acid exposure
    Andrew C Scallet
    Division of Neurotoxicology, National Center for Toxicological Research, USFDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 26:331-42. 2004
    ....

Research Grants8

  1. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of different ovarian hormone therapies on cognitive and neurobiological profiles of primates. ..
  2. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  3. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  4. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  5. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  6. Cognition and Estrogen in Menopause:A Monkey Model
    Mary Lou Voytko; Fiscal Year: 2006
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of ovarian hormone therapy on cognitive and neurobiological profiles of primates. ..
  7. Central trigeminal mechanisms in ocular pain
    DAVID BEREITER; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  8. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..