neuromuscular depolarizing agents

Summary

Summary: Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.

Top Publications

  1. ncbi Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
    C Lysakowski
    Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 51:848-57. 2007
  2. doi Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid
    A Perez-Gomez
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PEI, Canada
    Neuroscience 208:97-108. 2012
  3. ncbi Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
    Mathias Sluga
    Department of Anesthesia, Krankenhaus Thusis, Switzerland
    Anesth Analg 101:1356-61. 2005
  4. doi Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy
    Daphne A Gill
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada
    Brain Res 1331:114-23. 2010
  5. ncbi Domoic acid-induced hippocampal CA1 hyperexcitability independent of region CA3 activity
    P Sari
    Department of Pharmacology, University of Otago School of Medical Sciences, PO Box 913, Dunedin, New Zealand
    Epilepsy Res 47:65-76. 2001
  6. pmc Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases
    G Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurochem Int 52:1100-5. 2008
  7. doi Rocuronium vs. succinylcholine in the emergency department: a critical appraisal
    William K Mallon
    Department of Emergency Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Emerg Med 37:183-8. 2009
  8. ncbi Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006
  9. pmc Is succinylcholine appropriate or obsolete in the intensive care unit?
    L H Booij
    Institute for Anaesthesiology, University Hospital Nijmegen, Sint Radboud, Nijmegen, The Netherlands
    Crit Care 5:245-6. 2001
  10. ncbi Domoic acid neurotoxicity in cultured cerebellar granule neurons is controlled preferentially by the NMDA receptor Ca(2+) influx pathway
    Frederick W Berman
    Department of Physiology and Pharmacology, Rm 2223, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Brain Res 924:20-9. 2002

Research Grants

  1. OPIATE MODULATION OF CORNEA PAIN PATHWAYS
    DAVID BEREITER; Fiscal Year: 1999
  2. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
  3. Estrogen and Psychological Stress in TMJD Pain
    David A Bereiter; Fiscal Year: 2010
  4. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
  5. OPIATE MODULATION OF CORNEA PAIN PATHWAYS
    DAVID BEREITER; Fiscal Year: 2003
  6. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2007
  7. Central trigeminal mechanisms in ocular pain
    DAVID BEREITER; Fiscal Year: 2007
  8. Cognition and Estrogen in Menopause:A Monkey Model
    Mary Lou Voytko; Fiscal Year: 2006
  9. Estrogen and Inflammation in TMD Pain
    DAVID BEREITER; Fiscal Year: 2006
  10. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006

Detail Information

Publications160 found, 100 shown here

  1. ncbi Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
    C Lysakowski
    Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 51:848-57. 2007
    ..Propofol-rocuronium is thought to be superior to thiopental-rocuronium for rapid sequence intubation (RSI). The role of the intubation model per se has never been investigated...
  2. doi Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid
    A Perez-Gomez
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PEI, Canada
    Neuroscience 208:97-108. 2012
    ....
  3. ncbi Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
    Mathias Sluga
    Department of Anesthesia, Krankenhaus Thusis, Switzerland
    Anesth Analg 101:1356-61. 2005
    ..We conclude that during rapid sequence induction of anesthesia in emergent cases, succinylcholine allows for a more rapid endotracheal intubation sequence and creates superior intubation conditions compared with rocuronium...
  4. doi Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy
    Daphne A Gill
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada
    Brain Res 1331:114-23. 2010
    ....
  5. ncbi Domoic acid-induced hippocampal CA1 hyperexcitability independent of region CA3 activity
    P Sari
    Department of Pharmacology, University of Otago School of Medical Sciences, PO Box 913, Dunedin, New Zealand
    Epilepsy Res 47:65-76. 2001
    ....
  6. pmc Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases
    G Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurochem Int 52:1100-5. 2008
    ..Inhibitors of p38 (SB203580) and of JNK (SP600125) antagonize DomA-induced apoptosis. These results indicate the importance of oxidative stress-activated JNK and p38 MAP kinase pathways in DomA-induced apoptosis in CGNs...
  7. doi Rocuronium vs. succinylcholine in the emergency department: a critical appraisal
    William K Mallon
    Department of Emergency Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Emerg Med 37:183-8. 2009
    ..Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias...
  8. ncbi Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006
    ....
  9. pmc Is succinylcholine appropriate or obsolete in the intensive care unit?
    L H Booij
    Institute for Anaesthesiology, University Hospital Nijmegen, Sint Radboud, Nijmegen, The Netherlands
    Crit Care 5:245-6. 2001
    ..The adverse effect profile of succinylcholine is such that its use in the ICU must be considered obsolete. Suitable alternatives are the intermediately long-acting nondepolarizing relaxants, of which rocuronium is probably preferable...
  10. ncbi Domoic acid neurotoxicity in cultured cerebellar granule neurons is controlled preferentially by the NMDA receptor Ca(2+) influx pathway
    Frederick W Berman
    Department of Physiology and Pharmacology, Rm 2223, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Brain Res 924:20-9. 2002
    ..Neurochem. 71 (1998) 2349], which suggests that elevation of [Ca(2+)](i) in the vicinity of the NMDA receptor ion channel activates processes leading to neuronal death...
  11. ncbi Propofol reduces succinylcholine induced increase of masseter muscle tone
    W C Ummenhofer
    Department of Anaesthesia, University of Basel, Kantonsspital, Switzerland
    Can J Anaesth 45:417-23. 1998
    ....
  12. ncbi A comparison of succinylcholine and rocuronium for rapid-sequence intubation of emergency department patients
    E G Laurin
    Division of Emergency Medicine, University of California, Davis, Medical Center, University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Emerg Med 7:1362-9. 2000
    ..To compare rocuronium and succinylcholine for rapid-sequence intubation (RSI) in the emergency department (ED)...
  13. pmc Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial
    Stephan C Marsch
    Department of Medical Intensive Care, University Hospital Basel, University of Basel, Petersgraben 4, Basel 4031, Switzerland
    Crit Care 15:R199. 2011
    ..Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI...
  14. ncbi Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 28:673-80. 2006
    ..However, the sublethal persistent neurobehavioral toxicity appears to be less pervasive than reported effects following DA administered mid-gestation...
  15. ncbi Acute parenteral neurotoxicity of domoic acid in cynomolgus monkeys (M. fascicularis)
    L Tryphonas
    Toxicology Research Division, Health Protection Branch, Health and Welfare Canada, Ottawa
    Toxicol Pathol 18:297-303. 1990
    ..It was concluded that D.A., administered intravenously, is neuroexcitatory and a powerful emetic at doses of 0.025 to 0.2 mg/kg. At higher doses (0.5 mg/kg intravenously and 4 mg/kg intraperitoneally), D.A. is strongly excitotoxic...
  16. ncbi Acute neurotoxicity of domoic acid in the rat
    L Tryphonas
    Toxicology Research Division, Health and Welfare Canada, Ottawa
    Toxicol Pathol 18:1-9. 1990
    ..The results of this study suggest that domoic acid is excitotoxic and causes a characteristic syndrome with clinical signs and histopathologic lesions similar to those reported for kainic acid...
  17. ncbi Suspected malignant hyperthermia reactions in New Zealand
    A N Pollock
    Department of Anaesthesia, Palmerston North Hospital, New Zealand
    Anaesth Intensive Care 30:453-61. 2002
    ..This test also demonstrated the shortcomings of the Malignant Hyperthermia Clinical Grading Scale...
  18. ncbi Traumatic asphyxia: a case report and anesthetic implications
    Mazen Elias
    Pain Management Clinic, 704 S Webster Ave, Green Bay Wisconsin, WI 54301, USA
    Middle East J Anesthesiol 17:455-62. 2003
  19. ncbi Succinylcholine vs rocuronium for intubation in the intensive care unit
    Kathryn Regan
    National Hospital for Neurology and Neurosurgery, London WC1N 3BG
    Br J Hosp Med (Lond) 66:548. 2005
  20. ncbi Use of remifentanil for tracheal intubation for caesarean section in a patient with suxamethonium apnoea
    R Alexander
    Department of Anaesthetics, Worcestershire Royal Hospital, Charles Hastings Way, Worcester WR5 1DD, UK
    Anaesthesia 60:1036-8. 2005
    ..The parturient awoke following an uneventful caesarean section with excellent pain relief and no recall. The baby had normal Apgar scores and umbilical blood gas measurements...
  21. ncbi Tracheal intubating conditions and apnoea time after small-dose succinylcholine are not modified by the choice of induction agent
    M I El-Orbany
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA
    Br J Anaesth 95:710-4. 2005
    ..v. induction drugs on tracheal intubation conditions and apnoea time after small-dose (0.6 mg kg(-1)) succinylcholine used to facilitate orotracheal intubation at an urban, university-affiliated community medical centre...
  22. ncbi Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium
    J R Ortiz-Gómez
    University Clinic, Department of Anesthesiology and Intensive Care, Navarra, Spain
    Eur J Anaesthesiol 22:263-8. 2005
    ..To evaluate orotracheal intubation conditions after 1 min...
  23. ncbi [Application of muscle relaxants for rapid-sequence induction of anaesthesia]
    R Hofmockel
    Klinik für Anästhesiologie und Intensivtherapie, Universitat Rostock
    Anaesthesist 52:516-21. 2003
    ..It is the opinion of the authors that timing but also drugs with a slow onset (e.g., alcuronium and Pancuronium) are obsolete in the context of RSI...
  24. ncbi Controversies in rapid sequence intubation in children
    Audrey Zelicof-Paul
    Department of Pediatrics, Emergency Division, The Children s Hospital of New York Presbyterian, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Pediatr 17:355-62. 2005
    ..The purpose of the present review is to address several controversies pertaining to emergency department rapid sequence intubation of children...
  25. ncbi General anesthesia with remifentanil for Cesarean section in a patient with HELLP syndrome
    F Richa
    Department of Anesthesia and Intensive Care, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon
    Acta Anaesthesiol Scand 49:418-20. 2005
    ..We report the management of a patient presenting in labor with HELLP syndrome, and describe the successful use of remifentanil as part of the anesthetic technique for her subsequent Cesarean section...
  26. ncbi Modification of mediators of immune reaction after general anaesthesia
    A Sanchez Palacios
    Unidad de Alergologia, Hospital Universitario Insular de G C Las Palmas, Gran Canaria, Spain
    Allergol Immunopathol (Madr) 32:352-60. 2004
    ....
  27. ncbi Hyperkalemia and pyloric stenosis
    Donald Schwartz
    Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts 01199, USA
    Anesth Analg 97:355-7, table of contents. 2003
    ..Thirty-six percent of patients with pyloric stenosis had increased serum potassium levels. We conclude that hyperkalemia may be more common in children with pyloric stenosis than previously thought...
  28. ncbi Suxamethonium administration prolongs the duration of action of subsequent rocuronium
    E N Robertson
    University Medical Center, Department of Anesthesiology, Nijmegen, The Netherlands
    Eur J Anaesthesiol 21:734-7. 2004
    ..The neuromuscular effects of suxamethonium and rocuronium, and their effects on intraocular pressure (IOP), heart rate (HR) and arterial pressure were also recorded...
  29. ncbi Effect of ephedrine on the onset time of succinylcholine
    S Ganidagli
    Department of Anaesthesiology and Reanimation, Harran University Medical School, Sanliurfa, Turkey
    Acta Anaesthesiol Scand 48:1306-9. 2004
    ..The aim of this study was to evaluate the effect of ephedrine administered prior to induction of anaesthesia on the onset time of succinylcholine for endotracheal intubation...
  30. ncbi Anesthesia for removal of inhaled foreign bodies in children
    Amit Soodan
    Department of Anaesthesiology, All India Institute of Medical Sciences, New Delhi, India
    Paediatr Anaesth 14:947-52. 2004
    ..This prospective randomized clinical trial was undertaken to compare spontaneous and controlled ventilation during anesthesia for removal of inhaled foreign bodies in children...
  31. ncbi The Combitube as a salvage airway device for paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, CA 92103 8676, USA
    Ann Emerg Med 42:697-704. 2003
    ..Here we describe our experience with the Combitube (esophageal-tracheal twin-lumen airway device) as a salvage airway device for paramedic rapid sequence intubation...
  32. ncbi Anesthesia in Beckwith-Wiedemann syndrome
    V Celiker
    Department of Anaesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 14:778-80. 2004
    ..We did not have difficulty in airway management either with tracheal intubation or rigid bronchoscopy, but we could not extubate the baby because of tracheomalacia...
  33. ncbi Treatment of sarin exposure
    Peter DeBalli
    JAMA 291:181-2; author reply 182-3. 2004
  34. ncbi Propofol relieves post-extubation laryngospasm in obstetric anesthesia
    Vincenzo Fodale
    Int J Obstet Anesth 13:196-7. 2004
  35. ncbi Trauma in pregnancy: anesthetic management of a parturient with hypotensive shock and trauma to the gravid uterus
    T W Nelson
    Acta Anaesthesiol Scand 48:662. 2004
  36. ncbi Morbid obesity: a risk factor for maternal mortality
    Olubukola Nafiu
    Int J Obstet Anesth 16:187; author reply 187-8. 2007
  37. ncbi The dose of succinylcholine in morbid obesity
    Harry J M Lemmens
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 102:438-42. 2006
    ..Our study demonstrates that for complete neuromuscular paralysis and predictable laryngoscopy conditions, SCH 1 mg/kg total body weight is recommended...
  38. ncbi [Electroconvulsive therapy in the third trimester of pregnancy: a case report]
    R M Prieto Martin
    Servicio de Anestesiologia y Reanimacion, Hospital Universitario de Salamanca
    Rev Esp Anestesiol Reanim 53:653-6. 2006
    ..The patient experienced clear improvement and 2 days after the last treatment spontaneous labor commenced. A healthy boy was born by vaginal delivery...
  39. ncbi Intraocular pressure changes after succinylcholine and endotracheal intubation: a comparison of thiopental and propofol on IOP
    M B Khosravi
    Indian J Ophthalmol 55:164. 2007
  40. ncbi Anesthetic implications of botulinum toxin type A (Botox) injections for the treatment of 'the aging face' in the parturient
    K M Kuczkowski
    Acta Anaesthesiol Scand 51:515-6. 2007
  41. ncbi Posterior reversible encephalopathy syndrome during pregnancy: seizures in a previously healthy parturient
    Timothy R Long
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Anesth 19:145-8. 2007
    ..Prompt recognition and treatment of this potentially catastrophic disease may avert injury to the patient and neonate...
  42. ncbi Anaesthesia for caesarean section in a patient with acute generalised pustular psoriasis
    A Samieh-Tucker
    Department of Anaesthesia, Basildon University Hospital, Basildon, Essex, UK
    Int J Obstet Anesth 16:375-8. 2007
    ..The purpose of this article is to delineate the clinical picture of this disease, its treatment, and the effect on the mother and the fetus...
  43. ncbi Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers
    Paul Michel Mertes
    Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
    Anesthesiology 107:245-52. 2007
    ..Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs)...
  44. ncbi The effects of magnesium sulphate-pretreatment on suxamethonium-induced complications during induction of general endotracheal anaesthesia
    K Y Danladi
    Department of Anaesthesia, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
    Afr J Med Med Sci 36:43-7. 2007
    ..The average of 0.034 mmol/L in Group B was not significant {p value 0.06}. We advocate the use of magnesium pretreatment in all patients at risk of these complications...
  45. ncbi [Anesthesia for electroconvulsive therapy: clinical experience]
    A G Gonzalez
    Departamento de Anestesiologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Esp Anestesiol Reanim 54:414-20. 2007
    ..To assess the utility of propofol and succinylcholine in obtaining optimal convulsions and assuring patient safety during electroconvulsive therapy...
  46. ncbi Anesthetic management for two infants undergoing surgery for tension pneumatoceles
    Chih Min Liu
    Paediatr Anaesth 17:189-90. 2007
  47. ncbi A comparison of intubating conditions in children following induction of anaesthesia with propofol and suxamethonium or propofol and remifentanil
    J M Morgan
    Department of Anaesthesia, Sheffield Children s Hospital, Western Bank, Sheffield S10 2TH, UK
    Anaesthesia 62:135-9. 2007
    ..05). Mean apnoea time was 190 s in group S, and 362 s in group R (p<0.001). Heart rate increased in response to suxamethonium (p<0.01) and both systolic and diastolic blood pressure decreased in the remifentanil group (p<0.01)...
  48. ncbi Rocuronium versus succinylcholine for rapid tracheal intubation
    Aaron F Kopman
    Anesth Analg 102:1912; author reply 1912-3. 2006
  49. ncbi Rocuronium in emergent intubation
    C Chamorro
    Anesth Analg 103:253-4. 2006
  50. ncbi Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction
    S Sakuraba
    Department of Anesthesiology, School of Medicine, Keio University, Tokyo, Japan
    Acta Anaesthesiol Belg 57:253-7. 2006
    ....
  51. ncbi [Neuromuscular blockades. Agents, monitoring and antagonism]
    J U Schreiber
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar
    Anaesthesist 55:1225-35; quiz 1236. 2006
    ..Therefore, the monitoring of neuromuscular recovery plays an important role in the prevention of postoperative complications due to residual paralysis. In case of residual paralysis, cholinesterase inhibitors are suitable for reversal...
  52. ncbi [Does rocuronium displace the position of suxamethonium?]
    Tomoki Sasakawa
    Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Asahikawa 078 8510
    Masui 57:860-8. 2008
    ..Once Org 25969 (sugammadex) is available to rapidly bind rocuronium and reverse its action, rocuronium may replace succinylcholine for rapid-sequence induction...
  53. ncbi Which muscle relaxants should be used in day surgery and when
    Gabriella Bettelli
    Department of Anaesthesia and Intensive Care, University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy
    Curr Opin Anaesthesiol 19:600-5. 2006
    ..Agent selection criteria are discussed...
  54. ncbi Lidocaine or diazepam can decrease fasciculation induced by succinylcholine during induction of anesthesia
    Mansour Hassani
    Tehran University of Medical Sciences, Hassan Abad Square, Sina Hospital, Tehran, Iran
    Middle East J Anesthesiol 18:929-31. 2006
    ..There is no significant difference between these two drugs in reducing fasciculations moreover, these drugs can also prevent raised blood pressure and heart rate during intubation...
  55. ncbi Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions
    O Karcioglu
    Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey
    Int J Clin Pract 60:1638-46. 2006
    ..1% increase (95% CI = 13.7-24.5) in the frequency of excellent ETI conditions. SCH appears to be superior to RCR in creating excellent ETI conditions and avoiding unacceptable ETI conditions...
  56. ncbi Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia
    Mona R Gätke
    Danish Cholinesterase Research Unit, Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Pharmacogenet Genomics 17:995-9. 2007
    ..We present three novel mutations in the butyrylcholinesterase gene (BCHE) identified in three families in which a member had experienced severely prolonged duration of action of succinylcholine...
  57. ncbi [Frequency distribution of dibucaine numbers in 24,830 patients]
    G Pestel
    Institut für Anaesthesiologie und Intensivmedizin, Leopoldina Krankenhaus, Schweinfurt
    Anaesthesist 52:495-9. 2003
    ..Measuring the dibucaine number identifies patients who are at risk. This study shows the frequency distribution of dibucaine numbers routinely measured and discusses avoidable clinical problems and economic implications...
  58. ncbi Effectiveness of continuous positive airway pressure to enhance pre-oxygenation in morbidly obese women
    D M Cressey
    Anaesthesia, Surgical and Anaesthetic Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Anaesthesia 56:680-4. 2001
    ..A brief period of lower mean heart rate in the CPAP group was the only statistically significant difference in cardiovascular parameters. There was no significant difference in the volume of gastric gas after induction between groups...
  59. ncbi Can lidocaine reduce succinylcholine induced postoperative myalgia?
    Somchai Amornyotin
    Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Med Assoc Thai 85:S969-74. 2002
    ..In conclusion, where succinylcholine is used, lidocaine is proven to be the useful pretreatment agent for the reduction of postoperative myalgia...
  60. ncbi Altered response to intravenous thiopental and succinylcholine in acute amphetamine abuse
    O Stibolt
    Department M, Copenhagen Hospital Corporation, Sct Hans Hospital, Roskilde, Denmark
    Acta Anaesthesiol Scand 46:609-10. 2002
    ..Amphetamine is a strong sympathomimetic and may therefore influence the course of anesthesia. We report the case of a patient with acute amphetamine abuse presenting difficulties during anesthesia...
  61. ncbi Are intubation conditions using rocuronium equivalent to those using succinylcholine?
    Jeffrey Joseph Perry
    Division of Emergency Medicine, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Acad Emerg Med 9:813-23. 2002
    ..To determine whether the intubation conditions created by rocuronium are equivalent to those of succinylcholine during rapid-sequence induction (RSI)...
  62. ncbi The effect of isoflurane 0.6% on respiratory mechanics in anesthetized-paralyzed humans is not increased at concentrations of 0.9% and 1.2%
    Pedro Ruiz
    Department of Anesthesia, McGill University, Montreal, Quebec, Canada
    Can J Anaesth 50:67-70. 2003
    ..To assess the dose-dependent effect of low concentrations of isoflurane on respiratory mechanics in normal subjects...
  63. ncbi Pretreatment before succinylcholine for outpatient anesthesia?
    Thomas Mencke
    Department of Anesthesia and Critical Care Medicine, University of the Saarland, Saar, Germany
    Anesth Analg 94:573-6; table of contents. 2002
    ..However, in most patients, pretreatment was associated with muscle weakness before loss of consciousness. Thus, there is no convincing evidence supporting routine pretreatment with succinylcholine...
  64. ncbi Rocuronium combined with i.v. lidocaine for rapid tracheal intubation
    D Yorukoglu
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Ankara, Ankara, Turkey
    Acta Anaesthesiol Scand 47:583-7. 2003
    ..We compared the intubating conditions and hemodynamic changes after the administration of rocuronium 0.6 mg kg(-1) and lidocaine 1.5 mg kg(-1) with rocuronium alone and succinylcholine 60 and 90 s after administration...
  65. ncbi Prehospital rapid-sequence intubation: a pilot training program
    Kory Kaye
    Region Hospital EMS, St Paul, Minnesota, USA
    Prehosp Emerg Care 7:235-40. 2003
    ..To develop a training program enabling paramedics to use sedation and paralytic medications to facilitate endotracheal intubation in patients who otherwise could not be successfully intubated...
  66. ncbi Anaphylaxis during surgical and interventional procedures
    Bernard Yu Hor Thong
    Department of Rheumatology, Allergy, and Immunology, Tan Tock Seng Hospital, Singapore
    Ann Allergy Asthma Immunol 92:619-28. 2004
    ..To describe the current evidence-based knowledge of the causes, diagnostic evaluation, and treatment of patients with anaphylaxis associated with surgical and interventional procedures...
  67. ncbi Cell death of motoneurons in the chick embryo spinal cord. XI. Acetylcholine receptors and synaptogenesis in skeletal muscle following the reduction of motoneuron death by neuromuscular blockade
    R W Oppenheim
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27103
    Development 107:331-41. 1989
    ..These receptor changes very likely reflect increased synaptogenesis in the muscles of paralyzed embryos which in turn may act to reduce motoneuron death by providing increased access to muscle-derived neurotrophic molecules...
  68. ncbi In vivo reversal of depolarizing neuromuscular blockade
    W F Riker
    Department of Anesthesiology and Pharmacology, New York Hospital Cornell Medical Center, New York, NY 10021, USA
    Arch Int Pharmacodyn Ther 330:90-101. 1995
    ..Tetraethyl- and tetrabutylammonium ions proved to be effective antagonists of succinylcholine block following inactivation of plasma cholinesterases by hexafluorenium...
  69. ncbi Evaluation of circulating eosinophil count and adrenal gland function in California sea lions naturally exposed to domoic acid
    Frances M D Gulland
    The Marine Mammal Center, Sausalito, CA 94965, USA
    J Am Vet Med Assoc 241:943-9. 2012
    ..To determine the effect of natural exposure to domoic acid (DA) on eosinophil counts and adrenal gland function in California sea lions (Zalophus californianus)...
  70. doi Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro
    Rémi Bos
    Institut de Neurosciences de la Timone, Unité Mixte Recherche 7289, Centre National de la Recherche Scientifique, and Aix Marseille Universite, Marseille, France
    J Neurophysiol 107:3107-15. 2012
    ..Glucose at its standard concentration appears to be an adequate ES for the neonatal spinal cord in vitro...
  71. ncbi Neurophysiology of glutamatergic signalling and anthelmintic action in Ascaris suum: pharmacological evidence for a kainate receptor
    R E Davis
    Department of Zoology, University of Wisconsin Madison 53706, USA
    Parasitology 116:471-86. 1998
    ..This glutamatergic pathway may play a role in nematode locomotory behaviour and account for the paralysing anthelmintic action of excitatory amino acid analogues like kainate and domoate...
  72. ncbi [Cisatracurium]
    J R Ortiz
    Departamento de Anestesiología y Cuidados Intensivos, Clínica Universitaria de Navarra Facultad de Medicina
    Rev Esp Anestesiol Reanim 45:242-7. 1998
    ..Cisatracurium is described as the nondepolarizing muscle relaxant of choice for medium-to-long-term surgery on hemodynamically unstable patients or those with kidney or liver disease, and for neuromuscular blockade in intensive care...
  73. doi [Effect of ephedrine on the intubation conditions using rocuronium versus succinylcholine]
    L Belyamani
    Service d anesthésiologie, hôpital militaire d instruction Mohammed V, Rabat, Maroc
    Ann Fr Anesth Reanim 27:292-6. 2008
    ..The goal of this study was to determine if ephedrine could improve intubating conditions when it is administered before the muscle relaxant (rocuronium and succinylcholine)...
  74. ncbi [Anesthetic complications. The incidence of severe anesthetic complications in patients and families with progressive muscular dystrophy of the Duchenne and Becker types]
    E Breucking
    Institut für Anästhesiologie, Intensivmedizin und Schmerztherapie, Klinikum Wuppertal GmbH, Klinik der Universität Witten Herdecke
    Anaesthesist 49:187-95. 2000
    ..We projected an inquiry about the incidence rate and type of severe anaesthetic complications in an utmost large number of patients and families with Duchenne (DMD) and Becker type (BMD) muscular dystrophy...
  75. ncbi Mediation of ionotropic glutamate receptors in domoic acid-induced striatal dopamine release in rats
    B A Quintela
    Department of Functional Biology and Health Sciences, Vigo University, Lagoas Marcosende, 36200, Vigo, Spain
    Eur J Pharmacol 401:173-7. 2000
    ..In conclusion, based on results with a microdialysis technique, we suggest that domoic acid may act through AMPA/kainate receptors in striatum...
  76. ncbi The anthelmintic pyrantel acts as a low efficacious agonist and an open-channel blocker of mammalian acetylcholine receptors
    D Rayes
    Instituto de Investigaciones Bioquimicas, UNS CONICET, Camino La Carrindanga Km 7, 8000, Bahia Blanca, Argentina
    Neuropharmacology 41:238-45. 2001
    ..Thus, by acting at the binding site pyrantel activates mammalian AChRs with low efficacy, and by sterical blockade of the pore, the activated channels are then rapidly inhibited...
  77. ncbi Canine colonic circular muscle generates action potentials without the pacemaker component
    L W Liu
    Department of Biomedical Science, McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 72:70-81. 1994
    ..Circular muscle cells are shown to be excitable and capable of generating oscillatory activity dominated by L-type calcium channel activity, which is regulated by K+ conductance...
  78. ncbi Profound pain due to propofol injection triggered severe bronchospasm in a smoker--A case report
    Ahed Zeidan
    Department of Anesthesia, Lebanese University, Sahel General Hospital, Beirut, Lebanon
    Middle East J Anesthesiol 18:939-42. 2006
  79. ncbi Difficult airway management of a child impaled through the neck
    E P Melillo
    Department of Anaesthesia, Birmingham Heartlands NHS Trust, Birmingham, UK
    Paediatr Anaesth 11:615-7. 2001
    ..The various options are discussed and the involvement of experienced personnel together with a clear preformulated plan of action is stressed...
  80. ncbi [Clinical administration of muscle relaxants for intubation]
    R Hofmockel
    ,
    Anaesthesiol Reanim 26:116-22. 2001
    ....
  81. ncbi Succinylcholine in the intensive care unit
    Bruce M Biccard
    Anesthesiology 96:253-4. 2002
  82. ncbi Development of a monoclonal antibody against domoic acid and its application in enzyme-linked immunosorbent assay and colloidal gold immunostrip
    Zih Jay Tsao
    Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan, and Tian Sheng Memorial Hospital, Tong Kong, Ping Tong, Taiwan
    J Agric Food Chem 55:4921-7. 2007
    ..The mAb-based cdELISA and immunostrip assay established in this study were sensitive and accurate for rapid screening of domoic acid in shellfish samples...
  83. doi Anesthetic considerations in the child with Costello syndrome: risks of cardiac arrest upon induction of anesthesia
    Mohanad Shukry
    Paediatr Anaesth 18:567-8. 2008
  84. ncbi Asystole during laryngoscopy of a patient with pleural and pericardial effusions
    Geraldine Syverud
    AANA J 76:165-6; author reply 166. 2008
  85. ncbi [Sudden vocal cord closure during general anesthesia using remifentanil]
    Tatsuro Kohno
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8501
    Masui 57:1213-7. 2008
    ..Therefore, supraglottic airway devices should be applied with caution during general anesthesia with remifentanil and sevoflurane without muscle relaxant...
  86. doi Ring fibers visualized by electron microscopy in a Japanese patient with malignant hyperthermia
    Yoshimasa Kitagawa
    Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, North 13, West 7, Kita ku, Sapporo, 060 8586, Japan
    Odontology 99:101-4. 2011
    ..The presence of ring fibers in this patient might indicate muscle regeneration, suggesting a recovery process from the MH episode...
  87. ncbi [Piriformis syndrome]
    Thomas Erauso
    Centre médical de la base de défense de Rennes, centre medical de garnison des écoles de Saint Cöetquidan, 56381 Guer Cedex 1
    Rev Prat 60:900-4. 2010
    ..Surgery may be considered only in a very limited number of cases, lack of response to the first line treatment and then only if it is the absolute diagnosis, diagnosis which must remain a diagnosis of exception, more so of exclusion...
  88. ncbi Action of MgSO4 differs from moricizine and verapamil on ouabain-induced ventricular tachycardia in normomagnesemic conscious dogs
    M A Vos
    Department of Cardiology, University of Limburg, Maastricht, The Netherlands
    J Cardiovasc Pharmacol 23:252-8. 1994
    ..5-1.0 mg/kg i.v.) terminated both fast and slow VTs. The cycle length of VT ranged from 280 to 320 ms (mean 300 +/- 15 ms) for moricizine and 260-330 ms (mean 300 +/- 25 ms) for verapamil.(ABSTRACT TRUNCATED AT 250 WORDS)..
  89. doi Anesthetic management of the pediatric bleeding tonsil
    Ryan G Fields
    Jersey Shore University Medical Center, Neptune, NJ, USA
    Paediatr Anaesth 20:982-6. 2010
    ..The aim of this retrospective cohort study was to determine the incidence and further define the anesthetic complications in this population...
  90. doi [Case-Report: Reversal of a deep neuromuscular block with sugammadex after rapid sequence induction with high-dose rocuronium bromide]
    Christian Adam
    Klinik für Anästhesie, Operative Intensiv und Palliativmedizin am Städtischen Klinikum Solingen gGmbH
    Anasthesiol Intensivmed Notfallmed Schmerzther 45:614-6. 2010
    ..v. sugammadex application...
  91. doi Efficacy of manual jet ventilation using Manujet III for bronchoscopic airway foreign body removal in children
    Shaoqing Li
    Department of Anesthesiology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, China
    Int J Pediatr Otorhinolaryngol 74:1401-4. 2010
    ..To evaluate the efficacy of a manual jet ventilation device for bronchoscopic removal of foreign bodies in children...
  92. ncbi To asses the effects of rocuronium pretreatment on succinylcholine induced fasciculations and postoperative myalgias
    Nighat Abbas
    Department of Anaesthesia, Liaquat National Hospital, Karachi
    J Pak Med Assoc 59:847-50. 2009
    ..To asses the effects of Rocuronium pretreatment on Succinylcholine induced Fasciculations and postoperative Myalgias...
  93. doi Prolongation of QT interval induced by electroconvulsive therapy is attenuated by landiolol
    Masayo Matsura
    Department of Anesthesiology, Aichi Gakuin University School of Dentistry, Nagoya, Japan
    J ECT 26:37-40. 2010
    ..The objective of this study was to determine if landiolol, ultra short-acting beta adrenoceptor antagonist, attenuates the prolongation of QT interval caused by electroconvulsive therapy (ECT)...
  94. doi Amnesic shellfish poisoning (ASP) toxins in plankton and molluscs from Luanda Bay, Angola
    Juan Blanco
    Centro de Investigacións Mariñas, Pedras de Corón s n, apdo 13, 36620 Vilanova de Arousa, Spain
    Toxicon 55:541-6. 2010
    ....
  95. ncbi Anaesthetists' nightmare: masseter spasm after induction in an undiagnosed case of myotonia congenita
    I Looi
    Neurology Unit of Medical Department, Penang Hospital
    Med J Malaysia 63:423-5. 2008
    ..Neither the patient nor the anaesthetist was aware of the diagnosis before this potentially lethal complication occurred...
  96. doi Severe bradycardia after anesthesia before electroconvulsive therapy
    Tom K Birkenhager
    Departments of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
    J ECT 26:53-4. 2010
    ..Replacing succinylcholine with mivacurium seemed to be a successful strategy in preventing bradycardia during the final 9 ECT sessions...
  97. ncbi Immunoglobulin E antibodies to rocuronium: a new diagnostic tool
    Didier G Ebo
    Department of Immunology Allergology, University of Antwerp, Belgium
    Anesthesiology 107:253-9. 2007
    ....
  98. doi Effect of some habitual cooking processes on the domoic acid concentration in the cockle (Cerastoderma edule) and Manila clam (Ruditapes philippinarum)
    A Vidal
    Instituto Tecnologico para el Control del Medio Marino de Galicia, Vilagarcia de Arousa, Spain
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1089-95. 2009
    ....
  99. ncbi Airway management in trauma
    O Langeron
    Department of Anesthesiology and Resuscitation, Pitie Salpetriere Hospital, Paris, France
    Minerva Anestesiol 75:307-11. 2009
    ....
  100. pmc Transmembrane voltage regulates binding of annexin V and lactadherin to cells with exposed phosphatidylserine
    Christina Smith
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195 7110, USA
    BMC Biochem 10:5. 2009
    ..Cells expose phosphatidylserine during apoptosis. The voltage across the plasma membrane also decreases or disappears during apoptosis, but the physiological significance of this is unknown...
  101. pmc Monitoring of neuromuscular function in the clinical setting
    D Kelly
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 66:473-89. 1993
    ..The principles reviewed in this paper will then be applied in the clinical setting, and risks and benefits associated with perioperative use of muscle relaxants will be discussed...

Research Grants60

  1. OPIATE MODULATION OF CORNEA PAIN PATHWAYS
    DAVID BEREITER; Fiscal Year: 1999
    ....
  2. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of different ovarian hormone therapies on cognitive and neurobiological profiles of primates. ..
  3. Estrogen and Psychological Stress in TMJD Pain
    David A Bereiter; Fiscal Year: 2010
    ..Our understanding of the neurobiology of persistent jaw pain will be improved by the use of new animal models that consider these known risk factors. ..
  4. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
    ....
  5. OPIATE MODULATION OF CORNEA PAIN PATHWAYS
    DAVID BEREITER; Fiscal Year: 2003
    ....
  6. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2007
    ....
  7. Central trigeminal mechanisms in ocular pain
    DAVID BEREITER; Fiscal Year: 2007
    ....
  8. Cognition and Estrogen in Menopause:A Monkey Model
    Mary Lou Voytko; Fiscal Year: 2006
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of ovarian hormone therapy on cognitive and neurobiological profiles of primates. ..
  9. Estrogen and Inflammation in TMD Pain
    DAVID BEREITER; Fiscal Year: 2006
    ..This information may lead to a better understanding of how the brain integrates pain-like signals relevant for TMD in women ..
  10. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  11. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  12. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  13. TRIGEMINAL CONTROL OF ADRENAL AUTONOMIC FUNCTION
    DAVID BEREITER; Fiscal Year: 1993
    ....
  14. TRIGEMINAL CONTROL OF ADRENAL AUTONOMIC FUNCTION
    DAVID BEREITER; Fiscal Year: 1990
    ..This proposal focuses on the spinal trigeminal system as a model to assess the degree of overlap between the sensory- discriminative and the autonomic aspects of nociception...
  15. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  16. SEX-RELATED OPIATE AND AUTONOMIC MECHANISMS IN TMD PAIN
    DAVID BEREITER; Fiscal Year: 2001
    ..The shorter term goal is to define the involvement of opiate and vagal afferent nerve mechanisms at the level of the trigeminal brainstem complex that may have analgesic effects after inflammation of the TMJ region. ..