diuretics

Summary

Summary: Agents that promote the excretion of urine through their effects on kidney function.

Top Publications

  1. ncbi Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
    Barry R Davis
    The University of Texas School of Public Health, Houston, TX 77030, USA
    Circulation 113:2201-10. 2006
  2. doi Diuretics: still essential drugs for the management of hypertension
    Flavio Danni Fuchs
    Servico de Cardiologia, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90 035 903, Porto Alegre, RS, Brazil
    Expert Rev Cardiovasc Ther 7:591-8. 2009
  3. ncbi A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly
    Lindon M H Wing
    School of Medicine, Flinders University, Adelaide, Australia
    N Engl J Med 348:583-92. 2003
  4. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
  5. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
  6. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
  7. ncbi WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
    Tetsuo Moriguchi
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Chiyoda, Tokyo 101 0062
    J Biol Chem 280:42685-93. 2005
  8. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
  9. doi The exact distribution of Cochran's heterogeneity statistic in one-way random effects meta-analysis
    Brad J Biggerstaff
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Stat Med 27:6093-110. 2008
  10. ncbi The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP
    Pablo Cabrero
    IBLS Division of Molecular Genetics, University of Glasgow, UK
    J Exp Biol 205:3799-807. 2002

Research Grants

  1. CELLULAR CALCIUM TRANSPORT IN URINARY EPITHELIA
    Peter Friedman; Fiscal Year: 2003
  2. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
  3. RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSS
    Douglas Kiel; Fiscal Year: 1993
  4. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
  5. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 1999
  6. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2009
  7. REGULATION OF KAPPA OPIOID RECEPTORS
    Lee Yuan Liu Chen; Fiscal Year: 2002
  8. Cellular Pharmacology of Kappa Opioid Receptor
    Lee Yuan Liu Chen; Fiscal Year: 2007
  9. Combined Computational and Wet Lab Screening for Drugs Tested via OATs
    Sanjay K Nigam; Fiscal Year: 2010
  10. CHARACTERIZATION OF INTESTINAL ABSORPTION OF VITAMIN B1
    HAMID SAID; Fiscal Year: 2003

Detail Information

Publications321 found, 100 shown here

  1. ncbi Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
    Barry R Davis
    The University of Texas School of Public Health, Houston, TX 77030, USA
    Circulation 113:2201-10. 2006
    ..The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF...
  2. doi Diuretics: still essential drugs for the management of hypertension
    Flavio Danni Fuchs
    Servico de Cardiologia, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90 035 903, Porto Alegre, RS, Brazil
    Expert Rev Cardiovasc Ther 7:591-8. 2009
    According to most current international guidelines for hypertension, diuretics are indicated for elderly and black patients, unless they have any of a long list of other preferential indications...
  3. ncbi A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly
    Lindon M H Wing
    School of Medicine, Flinders University, Adelaide, Australia
    N Engl J Med 348:583-92. 2003
    Treatment of hypertension with diuretics, beta-blockers, or both leads to improved outcomes. It has been postulated that agents that inhibit the renin-angiotensin system confer benefit beyond the reduction of blood pressure alone...
  4. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
    ..of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used...
  5. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
    ..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
  6. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
    ..angiotensin-converting-enzyme [ACE] inhibitors, calcium antagonists, angiotensin-receptor blockers [ARBs], and diuretics or beta blockers) or those targeting different blood pressure goals, on the risks of major cardiovascular events ..
  7. ncbi WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
    Tetsuo Moriguchi
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Chiyoda, Tokyo 101 0062
    J Biol Chem 280:42685-93. 2005
    ..clue to the pathophysiology of pseudohypoaldosteronism type II was its striking therapeutic response to thiazide diuretics, which are known to block the sodium chloride cotransporter (NCC)...
  8. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
    ....
  9. doi The exact distribution of Cochran's heterogeneity statistic in one-way random effects meta-analysis
    Brad J Biggerstaff
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Stat Med 27:6093-110. 2008
    ..The methodology is illustrated by revisiting a recent simulation study concerning the heterogeneity measures and applying all the proposed methods to four published meta-analyses...
  10. ncbi The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP
    Pablo Cabrero
    IBLS Division of Molecular Genetics, University of Glasgow, UK
    J Exp Biol 205:3799-807. 2002
    ..These cells also express receptors for leucokinin, another major diuretic peptide, implying that the cells may be important in homeostatic regulation...
  11. pmc The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus
    Tero Viitanen
    Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
    J Physiol 588:1527-40. 2010
    ..Our findings reveal a novel excitatory mode of action of KCC2 that can have substantial implications for the role of GABAergic transmission during ictal epileptiform activity...
  12. ncbi Current status of antihypertensive prescription and associated blood pressure control in Japan
    Hisao Mori
    Japanese Medical and Dental Practitioners for the Improvement of Medical Care, Tokyo, Japan
    Hypertens Res 29:143-51. 2006
    ..6%) prescribed component of such therapy. Prescriptions of beta-blockers (BBs) decreased and those of CCBs and diuretics (D) increased with age (p<0.001)...
  13. ncbi A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    JAMA 290:2805-16. 2003
    ..Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials...
  14. ncbi Pattern of drug utilization among hypertensives in a Nigerian teaching hospital
    K B Yusuff
    Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Pharmacoepidemiol Drug Saf 14:69-74. 2005
    ..To describe the drug utilization pattern among hypertensive patients in a tertiary care setting, assess the short-term outcome of anti-hypertensive drugs usage and identify points for future intervention to improve outcomes...
  15. ncbi Pediatric idiopathic intracranial hypertension
    Lubaina M Rangwala
    Neuro ophthalmology Services of the Children s Hospital of Philadelphia, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Surv Ophthalmol 52:597-617. 2007
    ....
  16. ncbi Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene
    Khalid Hussain
    London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
    J Pediatr 146:706-8. 2005
    ..This mutation resulted in a nearly complete absence of immunoreactive protein and a decrease in fibroblast SCHAD activity...
  17. ncbi Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics
    Sergio da Cunha
    Hospital Universitario Pedro Ernesto, IBRAG, Geologia UERJ, Rio de Janeiro, RJ, Brazil
    Arq Bras Cardiol 79:454-65. 2002
    ..the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease.
  18. ncbi Diuretics for Ménière's disease or syndrome
    A S Thirlwall
    Royal Berkshire Hospital, Ear, Nose and Throat Department, London Road, Reading, UK RG1 5AN
    Cochrane Database Syst Rev 3:CD003599. 2006
    Ménière's disease is a disorder characterised by hearing loss, tinnitus and disabling vertigo. Diuretics are used to try and reduce the severity and frequency of episodes but there is little evidence behind this treatment.
  19. doi Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial
    Augustine N Odili
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press 20:256-66. 2011
    ....
  20. ncbi Diuretics and bone loss in rats with aldosteronism
    Peter H Law
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Am Coll Cardiol 46:142-6. 2005
    ..We hypothesized that the increased urinary Ca2+ and Mg2+ excretion and bone loss that accompanies aldosteronism is aggravated with furosemide and is attenuated by spironolactone...
  21. ncbi Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    Stevo Julius
    University of Michigan, Ann Arbor, USA
    Lancet 363:2022-31. 2004
    ....
  22. pmc Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial
    Femke Waanders
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 53:16-25. 2009
    ..We hypothesized that a decrease in proteinuria by using therapeutic interventions is associated with decreased urinary KIM-1 levels...
  23. pmc The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis
    Amy B Cadwallader
    Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti, 1, Rome, Italy
    Br J Pharmacol 161:1-16. 2010
    b>Diuretics are drugs that increase the rate of urine flow and sodium excretion to adjust the volume and composition of body fluids...
  24. doi Hydrochlorothiazide versus chlorthalidone in the management of hypertension
    Kimberly M Neff
    New Mexico VA Health Care System, Albuquerque, NM, USA
    Cardiol Rev 18:51-6. 2010
    Thiazide diuretics are a mainstay for the treatment of hypertension...
  25. doi Reappraisal of the role of diuretics in heart failure
    Maya Guglin
    University of South Florida, Tampa, USA
    Cardiol Rev 17:56-9. 2009
    The focus of this review is to explore the controversy between the broad acceptance of loop diuretics as a first-line treatment for heart failure (HF) and the data regarding their association to increased morbidity and mortality in HF...
  26. ncbi Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytes
    Brian A MacVicar
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Glia 37:114-23. 2002
    ..In summary, these results indicated that KCl uptake into astrocytes via an Na-K-2Cl cotransporter during raised [K(+)](o) contributes to the generation of cellular swelling and the intrinsic optical signals...
  27. pmc Nephrotoxicity in the elderly due to co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs
    V Adhiyaman
    Department of Geriatric Medicine, Wrexham Maelor Hospital, Wrexham LL13 7TD, Wales, UK
    J R Soc Med 94:512-4. 2001
    ..remained stable in 6 patients: patients with deterioration in renal function were older and more likely to be on diuretics. This drug combination is commonly nephrotoxic in the elderly and should be avoided, especially in those taking ..
  28. ncbi Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensive
    A E Consolini
    Cátedra de Farmacodinamia, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
    J Ethnopharmacol 66:33-9. 1999
    ..Myrtaceae) is mostly due to a hypotensive effect mediated by a direct vasodilating activity, and to a weak diuretic effect that could be related to an increase in renal blood flow...
  29. ncbi Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats
    K H Reid
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
    Brain Res 864:134-7. 2000
    The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter ..
  30. ncbi Herbal medicines as diuretics: a review of the scientific evidence
    C I Wright
    Nutrition, Nutrition and Health Enhancement, Unilever Food and Health Research Institute, Olivier van Noortlaan 120, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
    J Ethnopharmacol 114:1-31. 2007
    ..e., hypertension). One class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as well as the amount of sodium in urine...
  31. doi Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial
    Peter H J van der Voort
    Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:533-8. 2009
    ..To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients...
  32. ncbi Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Thiazide diuretics are frequently used in these patients for treatment of hypertension, but they also exacerbate metabolic syndrome...
  33. doi Risk/benefit assessment of beta-blockers and diuretics precludes their use for first-line therapy in hypertension
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, 1000 10th Ave, Suite 3B 30, New York, NY 10019, USA
    Circulation 117:2706-15; discussion 2715. 2008
  34. ncbi Cystoid macular edema with docetaxel chemotherapy and the fluid retention syndrome
    David G Telander
    Department of Ophthalmology, University of California, Davis, Sacramento, CA, USA
    Semin Ophthalmol 22:151-3. 2007
    ..Successful management of CME with oral acetazolamide is also discussed...
  35. ncbi Furosemide and mannitol suppression of epileptic activity in the human brain
    Michael M Haglund
    Department of Surgery Neurosurgery and Neurobiology, Durham, NC 27710, USA
    J Neurophysiol 94:907-18. 2005
    ..Furosemide and other drugs that modulate the ECS might possess clinically useful antiepileptic properties, while avoiding the side effects associated with the suppression of neuronal excitability...
  36. doi Use of diuretics and risk of implant failure after primary total hip arthroplasty: a nationwide population-based study
    Theis M Thillemann
    Department of Orthopedics, Aarhus University Hospital, Denmark
    Bone 45:499-504. 2009
    Thiazid and loop diuretics have been associated with changes in bone mineral density and fracture risk. However, data on survival of prosthesis implants are lacking...
  37. ncbi High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial
    Felix Cantarovich
    Department of Transplantation and Intensive Care, Necker Hospital, Paris, France
    Am J Kidney Dis 44:402-9. 2004
    ..The effect of furosemide on the survival and renal recovery of patients presenting with acute renal failure (ARF) is still debated...
  38. doi Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 32:962-8. 2009
    ..These properties may provide cardiovascular protection in addition to the hypotensive effect...
  39. ncbi Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamide
    Rikke Søgaard
    Nordic Centre for Water Imbalance Related Disorders, Institute of Cellular and Molecular Medicine, Blegdamsvej 3C, University of Copenhagen, Blegdamsvej 3C, DK 2200, Copenhagen N, Denmark
    Pflugers Arch 456:285-92. 2008
    ..These parameters may vary between laboratories...
  40. pmc Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site
    Elton Migliati
    Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia
    Mol Pharmacol 76:105-12. 2009
    ..The identification of AQP-selective pharmacological agents opens opportunities for breakthrough strategies in the treatment of edema and other fluid imbalance disorders...
  41. pmc Partial resolution of diabetic macular oedema after systemic treatment with furosemide
    A P Ciardella
    Br J Ophthalmol 88:1224-5. 2004
  42. ncbi Diuretic use, residual renal function, and mortality among hemodialysis patients in the Dialysis Outcomes and Practice Pattern Study (DOPPS)
    Jennifer L Bragg-Gresham
    Arbor Research Collaborative for Health, formerly University Renal Research and Education Association, Ann Arbor, MI, USA
    Am J Kidney Dis 49:426-31. 2007
    ..Information about residual renal function (RRF) and outcomes associated with practices of diuretic use in patients with end-stage renal disease is not available worldwide...
  43. ncbi Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigators
    P S Sever
    Imperial College School of Medicine, London, UK
    J Hypertens 19:1139-47. 2001
    ..To test a second primary hypothesis that a statin compared with placebo will further protect against CHD endpoints in hypertensive subjects with a total cholesterol < or = 6.5 mmol/l...
  44. ncbi Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)
    M J Brown
    Clinical Pharmacology Unit, University of Cambridge, UK
    Lancet 356:366-72. 2000
    The efficacy of antihypertensive drugs newer than diuretics and beta-blockers has not been established...
  45. doi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    ..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  46. doi The Hong Kong diastolic heart failure study: a randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fraction
    G W K Yip
    Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    Heart 94:573-80. 2008
    ..The effect of renin-angiotensin blockade by irbesartan or ramipril in combination with diuretics on quality of life (QoL), regional and global systolic and diastolic function was assessed in HFNEF patients.
  47. ncbi Risk factors for thiazide-induced hyponatraemia
    K M Chow
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    QJM 96:911-7. 2003
    ..Thiazide-induced hyponatraemia is common and potentially life threatening. In the absence of well-defined risk factors for this complication, guidelines for prescribing cannot be established...
  48. doi Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazide
    Patrícia Guerrero
    Graduate Study Program in Health Sciences Cardiology, Universidade Federal do Rio Grande do Sul UFRGS, Brazil
    Clin Exp Hypertens 30:553-64. 2008
    ..Cough, albeit predominantly mild, was reported more frequently by participants treated with enalapril. We conclude that enalapril is more effective than amiloride to lower BP of patients on hydrochlorothiazide with uncontrolled BP...
  49. doi Risk of intraoperative hypotension with loop diuretics: a randomized controlled trial
    Nadia A Khan
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med 123:1059.e1-8. 2010
    ..Whether loop diuretics also induce intraoperative hypotension is uncertain...
  50. doi Diuretics and salt transport along the nephron
    Paul L Bernstein
    Division of Nephrology, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    Semin Nephrol 31:475-82. 2011
    The clinical use of diuretics almost uniformly predated the localization of their site of action...
  51. ncbi Antihypertensive therapy and incidence of type 2 diabetes in an elderly cohort
    Raj Padwal
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Diabetes Care 27:2458-63. 2004
    ..The aim of this study was to determine whether the incidence of type 2 diabetes differed among elderly users of four major antihypertensive drug classes...
  52. ncbi The ALLHAT Trial. Diuretics are still the preferred initial drugs for high blood pressure
    Donald G Vidt
    Department of Nephrology and Hypertension, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 70:263-9. 2003
    ..The doxazosin arm was terminated early because of an excess of congestive heart failure. Chlorthalidone was at least equivalent to amlodipine and lisinopril in all of the outcomes measured, and was better in some, notably heart failure...
  53. ncbi All hats off to ALLHAT: a massive study with clear messages
    John Chalmers
    J Hypertens 21:225-8. 2003
  54. pmc Back to thiazide-diuretics for hypertension: reflections after a decade of irrational prescribing
    Atle Fretheim
    Department of Health Services Research, Norwegian Directorate for Health and Social Affairs, N 0031 Oslo, Norway
    BMC Fam Pract 4:19. 2003
    ....
  55. doi Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker
    Takashi Uzu
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Clin Exp Nephrol 13:300-6. 2009
    ..Therefore, we examined the effects of the amount of sodium intake or diuretics in patients with diabetes treated with an angiotensin receptor blocker.
  56. ncbi The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure
    Ariel J Reyes
    Institute of Cardiovascular Theory, Sotelo 3908, 11700 Montevideo, Uruguay
    Eur J Heart Fail 7:461-7. 2005
    ..UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels worsening cardiac function also contributes to elevated serum UA ..
  57. doi The relationship between antihypertensive combination therapies comprising diuretics and/or beta-blockers and the risk of new-onset diabetes: a retrospective longitudinal cohort study
    Yi Sheng Liou
    Institute of Public Health, National Defence Medical Center, Taipei, Taiwan, ROC
    Hypertens Res 32:496-9. 2009
    We investigate the associations of antihypertensive drugs in double and triple combination regimens comprising diuretics and/or beta-blockers on the development of new-onset diabetes (NOD)...
  58. ncbi Loop diuretics: from the Na-K-2Cl transporter to clinical use
    Sudha S Shankar
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5124, USA
    Am J Physiol Renal Physiol 284:F11-21. 2003
    The diuretic response to loop diuretics in various disease states has consistently been found to be subnormal...
  59. ncbi Antihypertensive pharmacotherapy in a developing economy: pattern, acquisition costs and conformity to international guidelines in a tertiary-care setting
    C O Amira
    Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria
    J Hum Hypertens 20:894-7. 2006
  60. pmc Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive rats
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    PLoS ONE 7:e39162. 2012
    ....
  61. ncbi The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects
    H Knauf
    Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
    Eur J Clin Pharmacol 62:885-92. 2006
    Thiazide diuretics are known to induce a transient fall of the glomerular filtration rate (GFR), which, in turn, reduces tubular Na(+) load. This tubuloglomerular feedback (TGF) curtails the natriuretic effect of this class of diuretics...
  62. doi Diuretics and disorders of calcium homeostasis
    Marvin Grieff
    Rochester General Hospital, University of Rochester School of Medicine, Rochester, NY 14621, USA
    Semin Nephrol 31:535-41. 2011
    b>Diuretics commonly are administered in disorders of sodium balance. Loop diuretics inhibit the Na-K-2Cl transporter and also increase calcium excretion. They are often used in the treatment of hypercalcemia...
  63. doi Diuretics in acute kidney injury
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 31:523-34. 2011
    ..A variety of interventions, including loop diuretics, have been tested for the prevention and treatment of AKI; however, none to date have shown convincing benefits ..
  64. ncbi Metabolic side effects and cardiovascular events of diuretics: should a diuretic remain the first choice therapy in hypertension treatment? The case of yes
    Dimitris P Papadopoulos
    Hypertension and Cardiovascular Research Clinic, Georgetown University, Washington, DC, USA
    Clin Exp Hypertens 29:503-16. 2007
    ..The efficacy and safety of diuretics has been shown in many clinical trials...
  65. doi Diuretics for hypertension--an inconsistency in primary care prescribing behaviour
    Thomas Kuehlein
    University Hospital Heidelberg, Department of General Practice and Health Services Research, Heidelberg, Germany
    Curr Med Res Opin 27:497-502. 2011
    Internationally there is an ongoing debate on diuretics as first-line therapy for most patients with hypertension...
  66. ncbi Using BOLD imaging to measure renal oxygenation dynamics in rats injected with diuretics
    Yoshinori Kusakabe
    Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Magn Reson Med Sci 9:187-94. 2010
    we used blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI) to measure renal oxygenation dynamics in rats injected with diuretics and evaluated diuretic effect on renal oxygenation.
  67. ncbi High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics
    Claudio Brunelli
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, Italy
    J Sep Sci 29:2765-71. 2006
    ..to the routine screening of two different classes of doping agents, namely beta-adrenoceptor ligands and diuretics (belonging to the S3, P2, and S5 groups of the WADA list of prohibited substances)...
  68. ncbi Effectiveness of add-on low-dose diuretics in combination therapy for hypertension: losartan/hydrochlorothiazide vs. candesartan/amlodipine
    Tatsuo Shimosawa
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hypertens Res 30:831-7. 2007
    ..Although diuretics or calcium channel blockers are commonly used as add-ons to angiotensin receptor blocker (ARB), the most ..
  69. pmc The combination of amlodipine and angiotensin receptor blocker or diuretics in high-risk hypertensive patients: rationale, design and baseline characteristics
    W Wang
    Department of Evidence Based Medicine, Cardiovascular Institute and Fuwai Hospital, Beijing, PR China
    J Hum Hypertens 25:271-7. 2011
    ..controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardial ..
  70. ncbi A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs
    J A Karlsson
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, United Kingdom
    J Appl Physiol (1985) 72:434-8. 1992
    The effects of nebulized diuretics on citric acid-induced cough and airway obstruction in guinea pigs and capsaicin-induced cough and increase in airway resistance in humans have been studied...
  71. pmc Effect of diuretics on fetal growth: A drug effect or confounding by indication? Pooled Danish and Scottish cohort data
    C Olesen
    The Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus, DK 8000 Aarhus C, Denmark
    Br J Clin Pharmacol 51:153-7. 2001
    The diabetogenic effect of diuretics, as well as the indication for prescribing them, may impact on fetal growth...
  72. ncbi Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure
    Kamala P Tamirisa
    Department of Internal Medicine, Women s L3623 0271, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Am Heart J 148:971-8. 2004
    ..We therefore sought to determine the prevalence and clinical associations of hyperkalemia and renal insufficiency in heart failure patients treated with spironolactone...
  73. pmc Calcium channel blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors: effectiveness in combination with diuretics or beta-blockers for treating hypertension
    John D Bisognano
    Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, New York 14642 8679, USA
    Vasc Health Risk Manag 3:579-85. 2007
    ..DHPs), angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) added to diuretics or beta-blockers...
  74. ncbi Very-low-dose combination: a first-line choice for the treatment of hypertension?
    Bernard Waeber
    Division of Clinical Pathophysiology, University Hospital, BH 19, 1011 Lausanne, Switzerland
    J Hypertens Suppl 21:S3-10. 2003
    ..This is, for instance, the case for diuretics, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT1) receptor antagonists ..
  75. pmc Metabolic effects of an AT1-receptor blockade combined with HCTZ in cardiac risk patients: a non interventional study in primary care
    Peter Bramlage
    Institute for Clinical Pharmacology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
    BMC Cardiovasc Disord 8:30. 2008
    ..For example, diuretics and betablockers worsen glucose metabolism, hence the starting point of the current subanalysis of the CHILI (..
  76. ncbi Current usage of diuretics among hypertensive patients in Japan: the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study
    Kayo Murai
    Department of Planning for Drug Development, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
    Hypertens Res 29:857-63. 2006
    ..Measurement Evaluation (J-HOME) study, we examined the current situation with respect to the prescription of diuretics, including the prevalence of diuretic treatment and the dosages used for patients with essential hypertension in ..
  77. ncbi Antihypertensive efficacy and tolerability of candesartan-hydrochlorothiazide 32/12.5 mg and 32/25 mg in patients not optimally controlled with candesartan monotherapy
    Gerd Bönner
    MEDIAN Kliniken, Bad Krozingen, Germany
    Blood Press Suppl 2:22-30. 2008
    ..To evaluate the efficacy and tolerability of candesartan cilexetil 32 mg in combination with hydrochlorothiazide (HCT) 12.5 mg or 25 mg in hypertensive patients not optimally controlled with candesartan monotherapy...
  78. doi Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients
    Toshio Ogihara
    Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 32:163-7. 2009
    ..Safety and tolerability will also be investigated. A total of more than 4000 patients were recruited and will be followed up for at least 3 years...
  79. ncbi Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled study with bumetanide
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 21:163-70. 2006
    To study effects of loop diuretics on bone, 87 women were randomized to 1 year of treatment with bumetanide or placebo. Compared with placebo, bumetanide decreased BMD by 2% at the total hip and by 1.4% at the whole body...
  80. ncbi Changes in brain natriuretic peptide levels and bioelectrical impedance measurements after treatment with high-dose furosemide and hypertonic saline solution versus high-dose furosemide alone in refractory congestive heart failure: a double-blind study
    Salvatore Paterna
    Department of Emergency Medicine, University of Palermo, Palermo, Italy
    J Am Coll Cardiol 45:1997-2003. 2005
    ..The aim of this study was to evaluate the effect of a new treatment for refractory congestive heart failure (CHF) on brain natriuretic peptide (BNP) plasma levels and hydration station...
  81. ncbi Antihypertensive therapies
    Richard E T Smith
    Nat Rev Drug Discov 6:597-8. 2007
  82. ncbi Renal effects of treatment with diuretics, octreotide or both, in non-azotemic cirrhotic patients with ascites
    Georgios Kalambokis
    Department of Internal Medicine, Medical School of Ioannina, 45110 Ioannina, Greece
    Nephrol Dial Transplant 20:1623-9. 2005
    ..with renal dysfunction in cirrhotic patients with ascites, and in turn prevents the use of high doses of diuretics. Furthermore, ample evidence suggests that octreotide can inhibit the activation of the renin-aldosterone axis...
  83. ncbi Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    Mahboob Rahman
    Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    Arch Intern Med 165:936-46. 2005
    ....
  84. pmc Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status
    D Sankar
    Department of Biotechnology, Aarupadai Veedu Institute of Technology, Vinayaka Mission s Research Foundation University, Paiyanoor 603104, Chennai, Tamilnadu, India
    Yale J Biol Med 79:19-26. 2006
    ..investigate the effect of sesame oil in hypertensive patients who were on antihypertensive therapy either with diuretics (hydrochlorothiazide) or Beta-blockers (atenolol)...
  85. ncbi Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides
    Claudiu T Supuran
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Curr Pharm Des 14:641-8. 2008
    The widely clinically used benzothiadiazines and high ceiling diuretics, such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide, contain SO(2)NH(2) moieties acting ..
  86. ncbi Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-mediated apoptosis
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    J Biol Chem 279:43157-67. 2004
    Osmotic diuretics are used successfully to alleviate acute tubular necrosis (ATN) produced by chemotherapeutic agents and aminoglycoside antibiotics...
  87. ncbi Continuous haemodynamic monitoring during withdrawal of diuretics in patients with congestive heart failure
    F Braunschweig
    Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
    Eur Heart J 23:59-69. 2002
    ....
  88. doi Effects of ULTRAfiltration vs. DIureticS on clinical, biohumoral and haemodynamic variables in patients with deCOmpensated heart failure: the ULTRADISCO study
    Cristina Giglioli
    Department of Heart and Vessels, Viale Morgagni, 85, Florence, Italy
    Eur J Heart Fail 13:337-46. 2011
    To evaluate the clinical, biohumoral, and haemodynamic effects of ultrafiltration vs. intravenous diuretics in patients with decompensated heart failure (HF)...
  89. ncbi Rapid optimization: strategies for optimal care of decompensated congestive heart-failure patients in the emergency department
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Rev Cardiovasc Med 3:S41-8. 2002
    ....
  90. pmc Attenuated renal excretion in response to thiazide diuretics in Gitelman's syndrome: a case report
    Chung Ho Yeum
    Department of Internal Medicine, Cheju National University Medical School, Jeju, Korea
    J Korean Med Sci 17:567-70. 2002
    ..The administration of thiazide diuretics may induce a subnormal increase of urinary Na+ and Cl- excretion in patients with Gitelman's syndrome, ..
  91. doi Diuretics in clinical practice. Part II: electrolyte and acid-base disorders complicating diuretic therapy
    Pantelis A Sarafidis
    Section of Nephrology and Hypertension, 1st Department of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, St Kiriakidi 1, 54636, Thessaloniki, Greece
    Expert Opin Drug Saf 9:259-73. 2010
    ....
  92. ncbi Initial experience with fenoldopam after cardiac surgery in neonates with an insufficient response to conventional diuretics
    John M Costello
    Division of Cardiac Intensive Care, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Pediatr Crit Care Med 7:28-33. 2006
    ..We hypothesized that urine output would improve when fenoldopam was added to conventional diuretic therapy after neonatal cardiopulmonary bypass...
  93. pmc Gout, diuretics and the kidney
    E Pascual
    Ann Rheum Dis 65:981-2. 2006
  94. ncbi Interactions of human organic anion transporters with diuretics
    Habib Hasannejad
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 308:1021-9. 2004
    The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs...
  95. ncbi Potassium-sparing diuretics
    J D Horisberger
    Yale University School of Medicine, Department of Physiology, New Haven, Conn
    Ren Physiol 10:198-220. 1987
    Amiloride, triamterene, and the spirolactones are potassium-sparing diuretics which act on the distal parts of the nephron, from the late distal tubule to the collecting duct...
  96. ncbi Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents
    M R Lakshman
    Lipid Research Laboratory, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Arch Intern Med 159:551-8. 1999
    ..Concern based on the reported short-term adverse effects of antihypertensive agents on plasma lipid and lipoprotein profiles (PLPPs) has complicated the therapy for hypertension...
  97. doi Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significance
    Marco Metra
    Section on Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia, Italy
    Eur J Heart Fail 10:188-95. 2008
    ..Renal function is a powerful prognostic variable in patients with heart failure (HF). Hospitalisations for acute HF (AHF) may be associated with further worsening of renal function (WRF)...
  98. ncbi Adverse prognostic significance of new diabetes in treated hypertensive subjects
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
    Hypertension 43:963-9. 2004
    ..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes...
  99. pmc A propensity-matched study of the effects of chronic diuretic therapy on mortality and hospitalization in older adults with heart failure
    Ali Ahmed
    University of Alabama at Birmingham, and Veterans Affairs Medical Center, Birmingham, 1530 3rd Avenue South, CH19 219, Birmingham, Alabama 35294 2041, USA
    Int J Cardiol 125:246-53. 2008
    Non-potassium-sparing diuretics may increase mortality and hospitalizations in heart failure patients...
  100. ncbi [IQWIG Preliminary Report: Diuretics are the best antihypertensives. How does it go on with the high blood pressure therapy? (interview)]
    Peter Sawicki
    MMW Fortschr Med 149:6-8. 2007
  101. ncbi Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion
    Natarajan Aravindan
    Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University, Durham, North Carolina, USA
    Ren Fail 28:25-35. 2006
    Loop diuretics are known to affect renal hemodynamics and possibly gene transcription, but the specific effect of furosemide on renal angiogenesis gene expression after acute ischemia is not known...

Research Grants88

  1. CELLULAR CALCIUM TRANSPORT IN URINARY EPITHELIA
    Peter Friedman; Fiscal Year: 2003
    ..We will: 1) Test the hypothesis that thiazide diuretics can inhibit Na+/Ca2+ exchange; and 2) Characterize the stimulatory effects of PTH on Na+/Ca2+ exchange...
  2. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    ..of verapamil, and will significantly further our understanding of the pharmacogenetics of p-blockers, thiazide diuretics, and ACE inhibitors...
  3. RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSS
    Douglas Kiel; Fiscal Year: 1993
    ..for this change in BMD will include weight, physical activity (leisure), caffeine, smoking, alcohol, thiazide diuretics, testosterone levels, dietary calcium, 25 hydroxy-vitamin D levels and thyroid hormone replacement and hormone ..
  4. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
    ..cardiovascular drugs: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, all classes of diuretics, alpha blockers, beta-blockers, central alpha agonists, calcium antagonists, and estrogens...
  5. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 1999
    ..the thick ascending limb of the loop of Henle and represents the site of action of the clinically important loop diuretics furosemide and bumetanide. Importantly, expression of Nkcc2 transcripts is only observed in the kidney...
  6. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2009
    ..urinary sodium), medication adherence to HF drugs including angiotensin converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ..
  7. REGULATION OF KAPPA OPIOID RECEPTORS
    Lee Yuan Liu Chen; Fiscal Year: 2002
    ..Kappa agonists may be useful as analgesics, water diuretics and antipruritic agents...
  8. Cellular Pharmacology of Kappa Opioid Receptor
    Lee Yuan Liu Chen; Fiscal Year: 2007
    ..effects, including analgesia, dysphoria and water diuresis and kappa agonists may be useful as analgesics, water diuretics and antipruritic drugs...
  9. Combined Computational and Wet Lab Screening for Drugs Tested via OATs
    Sanjay K Nigam; Fiscal Year: 2010
    ..kidney, liver) of many common drugs (eg. antibiotics, antivirals, chemotherapeutics, NSAIDs, antihypertensives, diuretics)...
  10. CHARACTERIZATION OF INTESTINAL ABSORPTION OF VITAMIN B1
    HAMID SAID; Fiscal Year: 2003
    ..renal disease patients, the elderly, in inborn errors of thiamine metabolism, and in long-term users of diuretics. Humans and other mammals can not synthesize thiamine, and thus, must obtain the vitamin from exogenous sources ..
  11. Uric Acid and Hypertension in African-Americans
    Richard Johnson; Fiscal Year: 2007
    Thiazide diuretics are associated with many metabolic side effects including hyperuricemia, gout, insulin resistance, and hyperlipidemia. These very conditions are already highly prevalent in African-Americans...
  12. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..for calcium nephrolithiasis that have been proven effective in prospective placebo controlled trials, thiazide diuretics, potassium citrate salts, and allopurinol...