Genomes and Genes
Summary: Agents that promote the excretion of urine through their effects on kidney function.
Publications321 found, 100 shown here
- Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack TrialBarry R Davis
The University of Texas School of Public Health, Houston, TX 77030, USA
Circulation 113:2201-10. 2006..The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF...
- Diuretics: still essential drugs for the management of hypertensionFlavio Danni Fuchs
Servico de Cardiologia, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90 035 903, Porto Alegre, RS, Brazil
Expert Rev Cardiovasc Ther 7:591-8. 2009According to most current international guidelines for hypertension, diuretics are indicated for elderly and black patients, unless they have any of a long list of other preferential indications...
- A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderlyLindon M H Wing
School of Medicine, Flinders University, Adelaide, Australia
N Engl J Med 348:583-92. 2003Treatment of hypertension with diuretics, beta-blockers, or both leads to improved outcomes. It has been postulated that agents that inhibit the renin-angiotensin system confer benefit beyond the reduction of blood pressure alone...
- Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BBjorn Dahlof
Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
Lancet 366:895-906. 2005..of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used...
- Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trialHenry R Black
Rush Medical College of Rush University, Chicago, IL 60612, USA
JAMA 289:2073-82. 2003..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
- Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trialsFiona Turnbull
Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
Lancet 362:1527-35. 2003..angiotensin-converting-enzyme [ACE] inhibitors, calcium antagonists, angiotensin-receptor blockers [ARBs], and diuretics or beta blockers) or those targeting different blood pressure goals, on the risks of major cardiovascular events ..
- WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1Tetsuo Moriguchi
Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Chiyoda, Tokyo 101 0062
J Biol Chem 280:42685-93. 2005..clue to the pathophysiology of pseudohypoaldosteronism type II was its striking therapeutic response to thiazide diuretics, which are known to block the sodium chloride cotransporter (NCC)...
- Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failureMichael R Bristow
Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
N Engl J Med 350:2140-50. 2004....
- The exact distribution of Cochran's heterogeneity statistic in one-way random effects meta-analysisBrad J Biggerstaff
Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
Stat Med 27:6093-110. 2008..The methodology is illustrated by revisiting a recent simulation study concerning the heterogeneity measures and applying all the proposed methods to four published meta-analyses...
- The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMPPablo Cabrero
IBLS Division of Molecular Genetics, University of Glasgow, UK
J Exp Biol 205:3799-807. 2002..These cells also express receptors for leucokinin, another major diuretic peptide, implying that the cells may be important in homeostatic regulation...
- The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampusTero Viitanen
Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
J Physiol 588:1527-40. 2010..Our findings reveal a novel excitatory mode of action of KCC2 that can have substantial implications for the role of GABAergic transmission during ictal epileptiform activity...
- Current status of antihypertensive prescription and associated blood pressure control in JapanHisao Mori
Japanese Medical and Dental Practitioners for the Improvement of Medical Care, Tokyo, Japan
Hypertens Res 29:143-51. 2006..6%) prescribed component of such therapy. Prescriptions of beta-blockers (BBs) decreased and those of CCBs and diuretics (D) increased with age (p<0.001)...
- A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trialCarl J Pepine
Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
JAMA 290:2805-16. 2003..Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials...
- Pattern of drug utilization among hypertensives in a Nigerian teaching hospitalK B Yusuff
Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
Pharmacoepidemiol Drug Saf 14:69-74. 2005..To describe the drug utilization pattern among hypertensive patients in a tertiary care setting, assess the short-term outcome of anti-hypertensive drugs usage and identify points for future intervention to improve outcomes...
- Pediatric idiopathic intracranial hypertensionLubaina M Rangwala
Neuro ophthalmology Services of the Children s Hospital of Philadelphia, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Surv Ophthalmol 52:597-617. 2007....
- Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD geneKhalid Hussain
London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
J Pediatr 146:706-8. 2005..This mutation resulted in a nearly complete absence of immunoreactive protein and a decrease in fibroblast SCHAD activity...
- Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diureticsSergio da Cunha
Hospital Universitario Pedro Ernesto, IBRAG, Geologia UERJ, Rio de Janeiro, RJ, Brazil
Arq Bras Cardiol 79:454-65. 2002..the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease.
- Diuretics for Ménière's disease or syndromeA S Thirlwall
Royal Berkshire Hospital, Ear, Nose and Throat Department, London Road, Reading, UK RG1 5AN
Cochrane Database Syst Rev 3:CD003599. 2006Ménière's disease is a disorder characterised by hearing loss, tinnitus and disabling vertigo. Diuretics are used to try and reduce the severity and frequency of episodes but there is little evidence behind this treatment.
- Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trialAugustine N Odili
Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
Blood Press 20:256-66. 2011....
- Diuretics and bone loss in rats with aldosteronismPeter H Law
Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Am Coll Cardiol 46:142-6. 2005..We hypothesized that the increased urinary Ca2+ and Mg2+ excretion and bone loss that accompanies aldosteronism is aggravated with furosemide and is attenuated by spironolactone...
- Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trialStevo Julius
University of Michigan, Ann Arbor, USA
Lancet 363:2022-31. 2004....
- Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trialFemke Waanders
Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Am J Kidney Dis 53:16-25. 2009..We hypothesized that a decrease in proteinuria by using therapeutic interventions is associated with decreased urinary KIM-1 levels...
- The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysisAmy B Cadwallader
Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti, 1, Rome, Italy
Br J Pharmacol 161:1-16. 2010b>Diuretics are drugs that increase the rate of urine flow and sodium excretion to adjust the volume and composition of body fluids...
- Hydrochlorothiazide versus chlorthalidone in the management of hypertensionKimberly M Neff
New Mexico VA Health Care System, Albuquerque, NM, USA
Cardiol Rev 18:51-6. 2010Thiazide diuretics are a mainstay for the treatment of hypertension...
- Reappraisal of the role of diuretics in heart failureMaya Guglin
University of South Florida, Tampa, USA
Cardiol Rev 17:56-9. 2009The focus of this review is to explore the controversy between the broad acceptance of loop diuretics as a first-line treatment for heart failure (HF) and the data regarding their association to increased morbidity and mortality in HF...
- Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytesBrian A MacVicar
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Glia 37:114-23. 2002..In summary, these results indicated that KCl uptake into astrocytes via an Na-K-2Cl cotransporter during raised [K(+)](o) contributes to the generation of cellular swelling and the intrinsic optical signals...
- Nephrotoxicity in the elderly due to co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugsV Adhiyaman
Department of Geriatric Medicine, Wrexham Maelor Hospital, Wrexham LL13 7TD, Wales, UK
J R Soc Med 94:512-4. 2001..remained stable in 6 patients: patients with deterioration in renal function were older and more likely to be on diuretics. This drug combination is commonly nephrotoxic in the elderly and should be avoided, especially in those taking ..
- Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensiveA E Consolini
Cátedra de Farmacodinamia, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
J Ethnopharmacol 66:33-9. 1999..Myrtaceae) is mostly due to a hypotensive effect mediated by a direct vasodilating activity, and to a weak diuretic effect that could be related to an increase in renal blood flow...
- Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone ratsK H Reid
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
Brain Res 864:134-7. 2000The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter ..
- Herbal medicines as diuretics: a review of the scientific evidenceC I Wright
Nutrition, Nutrition and Health Enhancement, Unilever Food and Health Research Institute, Olivier van Noortlaan 120, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
J Ethnopharmacol 114:1-31. 2007..e., hypertension). One class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as well as the amount of sodium in urine...
- Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trialPeter H J van der Voort
Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
Crit Care Med 37:533-8. 2009..To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients...
- Thiazide diuretics exacerbate fructose-induced metabolic syndromeSirirat Reungjui
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
J Am Soc Nephrol 18:2724-31. 2007..Thiazide diuretics are frequently used in these patients for treatment of hypertension, but they also exacerbate metabolic syndrome...
- Risk/benefit assessment of beta-blockers and diuretics precludes their use for first-line therapy in hypertensionFranz H Messerli
Division of Cardiology, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, 1000 10th Ave, Suite 3B 30, New York, NY 10019, USA
Circulation 117:2706-15; discussion 2715. 2008
- Cystoid macular edema with docetaxel chemotherapy and the fluid retention syndromeDavid G Telander
Department of Ophthalmology, University of California, Davis, Sacramento, CA, USA
Semin Ophthalmol 22:151-3. 2007..Successful management of CME with oral acetazolamide is also discussed...
- Furosemide and mannitol suppression of epileptic activity in the human brainMichael M Haglund
Department of Surgery Neurosurgery and Neurobiology, Durham, NC 27710, USA
J Neurophysiol 94:907-18. 2005..Furosemide and other drugs that modulate the ECS might possess clinically useful antiepileptic properties, while avoiding the side effects associated with the suppression of neuronal excitability...
- Use of diuretics and risk of implant failure after primary total hip arthroplasty: a nationwide population-based studyTheis M Thillemann
Department of Orthopedics, Aarhus University Hospital, Denmark
Bone 45:499-504. 2009Thiazid and loop diuretics have been associated with changes in bone mineral density and fracture risk. However, data on survival of prosthesis implants are lacking...
- High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trialFelix Cantarovich
Department of Transplantation and Intensive Care, Necker Hospital, Paris, France
Am J Kidney Dis 44:402-9. 2004..The effect of furosemide on the survival and renal recovery of patients presenting with acute renal failure (ARF) is still debated...
- Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertensionToshihiko Ishimitsu
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
Hypertens Res 32:962-8. 2009..These properties may provide cardiovascular protection in addition to the hypotensive effect...
- Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamideRikke Søgaard
Nordic Centre for Water Imbalance Related Disorders, Institute of Cellular and Molecular Medicine, Blegdamsvej 3C, University of Copenhagen, Blegdamsvej 3C, DK 2200, Copenhagen N, Denmark
Pflugers Arch 456:285-92. 2008..These parameters may vary between laboratories...
- Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding siteElton Migliati
Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia
Mol Pharmacol 76:105-12. 2009..The identification of AQP-selective pharmacological agents opens opportunities for breakthrough strategies in the treatment of edema and other fluid imbalance disorders...
- Partial resolution of diabetic macular oedema after systemic treatment with furosemideA P Ciardella
Br J Ophthalmol 88:1224-5. 2004
- Diuretic use, residual renal function, and mortality among hemodialysis patients in the Dialysis Outcomes and Practice Pattern Study (DOPPS)Jennifer L Bragg-Gresham
Arbor Research Collaborative for Health, formerly University Renal Research and Education Association, Ann Arbor, MI, USA
Am J Kidney Dis 49:426-31. 2007..Information about residual renal function (RRF) and outcomes associated with practices of diuretic use in patients with end-stage renal disease is not available worldwide...
- Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigatorsP S Sever
Imperial College School of Medicine, London, UK
J Hypertens 19:1139-47. 2001..To test a second primary hypothesis that a statin compared with placebo will further protect against CHD endpoints in hypertensive subjects with a total cholesterol < or = 6.5 mmol/l...
- Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)M J Brown
Clinical Pharmacology Unit, University of Cambridge, UK
Lancet 356:366-72. 2000The efficacy of antihypertensive drugs newer than diuretics and beta-blockers has not been established...
- Treatment of hypertension in patients 80 years of age or olderNigel S Beckett
Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
N Engl J Med 358:1887-98. 2008..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
- The Hong Kong diastolic heart failure study: a randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fractionG W K Yip
Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
Heart 94:573-80. 2008..The effect of renin-angiotensin blockade by irbesartan or ramipril in combination with diuretics on quality of life (QoL), regional and global systolic and diastolic function was assessed in HFNEF patients.
- Risk factors for thiazide-induced hyponatraemiaK M Chow
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
QJM 96:911-7. 2003..Thiazide-induced hyponatraemia is common and potentially life threatening. In the absence of well-defined risk factors for this complication, guidelines for prescribing cannot be established...
- Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazidePatrícia Guerrero
Graduate Study Program in Health Sciences Cardiology, Universidade Federal do Rio Grande do Sul UFRGS, Brazil
Clin Exp Hypertens 30:553-64. 2008..Cough, albeit predominantly mild, was reported more frequently by participants treated with enalapril. We conclude that enalapril is more effective than amiloride to lower BP of patients on hydrochlorothiazide with uncontrolled BP...
- Risk of intraoperative hypotension with loop diuretics: a randomized controlled trialNadia A Khan
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Am J Med 123:1059.e1-8. 2010..Whether loop diuretics also induce intraoperative hypotension is uncertain...
- Diuretics and salt transport along the nephronPaul L Bernstein
Division of Nephrology, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
Semin Nephrol 31:475-82. 2011The clinical use of diuretics almost uniformly predated the localization of their site of action...
- Antihypertensive therapy and incidence of type 2 diabetes in an elderly cohortRaj Padwal
Division of General Internal Medicine, University of Alberta, Edmonton, Canada
Diabetes Care 27:2458-63. 2004..The aim of this study was to determine whether the incidence of type 2 diabetes differed among elderly users of four major antihypertensive drug classes...
- The ALLHAT Trial. Diuretics are still the preferred initial drugs for high blood pressureDonald G Vidt
Department of Nephrology and Hypertension, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 70:263-9. 2003..The doxazosin arm was terminated early because of an excess of congestive heart failure. Chlorthalidone was at least equivalent to amlodipine and lisinopril in all of the outcomes measured, and was better in some, notably heart failure...
- All hats off to ALLHAT: a massive study with clear messagesJohn Chalmers
J Hypertens 21:225-8. 2003
- Back to thiazide-diuretics for hypertension: reflections after a decade of irrational prescribingAtle Fretheim
Department of Health Services Research, Norwegian Directorate for Health and Social Affairs, N 0031 Oslo, Norway
BMC Fam Pract 4:19. 2003....
- Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blockerTakashi Uzu
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
Clin Exp Nephrol 13:300-6. 2009..Therefore, we examined the effects of the amount of sodium intake or diuretics in patients with diabetes treated with an angiotensin receptor blocker.
- The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failureAriel J Reyes
Institute of Cardiovascular Theory, Sotelo 3908, 11700 Montevideo, Uruguay
Eur J Heart Fail 7:461-7. 2005..UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels worsening cardiac function also contributes to elevated serum UA ..
- The relationship between antihypertensive combination therapies comprising diuretics and/or beta-blockers and the risk of new-onset diabetes: a retrospective longitudinal cohort studyYi Sheng Liou
Institute of Public Health, National Defence Medical Center, Taipei, Taiwan, ROC
Hypertens Res 32:496-9. 2009We investigate the associations of antihypertensive drugs in double and triple combination regimens comprising diuretics and/or beta-blockers on the development of new-onset diabetes (NOD)...
- Loop diuretics: from the Na-K-2Cl transporter to clinical useSudha S Shankar
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5124, USA
Am J Physiol Renal Physiol 284:F11-21. 2003The diuretic response to loop diuretics in various disease states has consistently been found to be subnormal...
- Antihypertensive pharmacotherapy in a developing economy: pattern, acquisition costs and conformity to international guidelines in a tertiary-care settingC O Amira
Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria
J Hum Hypertens 20:894-7. 2006
- Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive ratsEiichiro Yamamoto
Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
PLoS ONE 7:e39162. 2012....
- The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effectsH Knauf
Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
Eur J Clin Pharmacol 62:885-92. 2006Thiazide diuretics are known to induce a transient fall of the glomerular filtration rate (GFR), which, in turn, reduces tubular Na(+) load. This tubuloglomerular feedback (TGF) curtails the natriuretic effect of this class of diuretics...
- Diuretics and disorders of calcium homeostasisMarvin Grieff
Rochester General Hospital, University of Rochester School of Medicine, Rochester, NY 14621, USA
Semin Nephrol 31:535-41. 2011b>Diuretics commonly are administered in disorders of sodium balance. Loop diuretics inhibit the Na-K-2Cl transporter and also increase calcium excretion. They are often used in the treatment of hypercalcemia...
- Diuretics in acute kidney injurySagar U Nigwekar
Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Nephrol 31:523-34. 2011..A variety of interventions, including loop diuretics, have been tested for the prevention and treatment of AKI; however, none to date have shown convincing benefits ..
- Metabolic side effects and cardiovascular events of diuretics: should a diuretic remain the first choice therapy in hypertension treatment? The case of yesDimitris P Papadopoulos
Hypertension and Cardiovascular Research Clinic, Georgetown University, Washington, DC, USA
Clin Exp Hypertens 29:503-16. 2007..The efficacy and safety of diuretics has been shown in many clinical trials...
- Diuretics for hypertension--an inconsistency in primary care prescribing behaviourThomas Kuehlein
University Hospital Heidelberg, Department of General Practice and Health Services Research, Heidelberg, Germany
Curr Med Res Opin 27:497-502. 2011Internationally there is an ongoing debate on diuretics as first-line therapy for most patients with hypertension...
- Using BOLD imaging to measure renal oxygenation dynamics in rats injected with diureticsYoshinori Kusakabe
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Magn Reson Med Sci 9:187-94. 2010we used blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI) to measure renal oxygenation dynamics in rats injected with diuretics and evaluated diuretic effect on renal oxygenation.
- High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diureticsClaudio Brunelli
Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, Italy
J Sep Sci 29:2765-71. 2006..to the routine screening of two different classes of doping agents, namely beta-adrenoceptor ligands and diuretics (belonging to the S3, P2, and S5 groups of the WADA list of prohibited substances)...
- Effectiveness of add-on low-dose diuretics in combination therapy for hypertension: losartan/hydrochlorothiazide vs. candesartan/amlodipineTatsuo Shimosawa
Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Hypertens Res 30:831-7. 2007..Although diuretics or calcium channel blockers are commonly used as add-ons to angiotensin receptor blocker (ARB), the most ..
- The combination of amlodipine and angiotensin receptor blocker or diuretics in high-risk hypertensive patients: rationale, design and baseline characteristicsW Wang
Department of Evidence Based Medicine, Cardiovascular Institute and Fuwai Hospital, Beijing, PR China
J Hum Hypertens 25:271-7. 2011..controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardial ..
- A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigsJ A Karlsson
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, United Kingdom
J Appl Physiol (1985) 72:434-8. 1992The effects of nebulized diuretics on citric acid-induced cough and airway obstruction in guinea pigs and capsaicin-induced cough and increase in airway resistance in humans have been studied...
- Effect of diuretics on fetal growth: A drug effect or confounding by indication? Pooled Danish and Scottish cohort dataC Olesen
The Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus, DK 8000 Aarhus C, Denmark
Br J Clin Pharmacol 51:153-7. 2001The diabetogenic effect of diuretics, as well as the indication for prescribing them, may impact on fetal growth...
- Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failureKamala P Tamirisa
Department of Internal Medicine, Women s L3623 0271, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Am Heart J 148:971-8. 2004..We therefore sought to determine the prevalence and clinical associations of hyperkalemia and renal insufficiency in heart failure patients treated with spironolactone...
- Calcium channel blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors: effectiveness in combination with diuretics or beta-blockers for treating hypertensionJohn D Bisognano
Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, New York 14642 8679, USA
Vasc Health Risk Manag 3:579-85. 2007..DHPs), angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) added to diuretics or beta-blockers...
- Very-low-dose combination: a first-line choice for the treatment of hypertension?Bernard Waeber
Division of Clinical Pathophysiology, University Hospital, BH 19, 1011 Lausanne, Switzerland
J Hypertens Suppl 21:S3-10. 2003..This is, for instance, the case for diuretics, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT1) receptor antagonists ..
- Metabolic effects of an AT1-receptor blockade combined with HCTZ in cardiac risk patients: a non interventional study in primary carePeter Bramlage
Institute for Clinical Pharmacology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
BMC Cardiovasc Disord 8:30. 2008..For example, diuretics and betablockers worsen glucose metabolism, hence the starting point of the current subanalysis of the CHILI (..
- Current usage of diuretics among hypertensive patients in Japan: the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) studyKayo Murai
Department of Planning for Drug Development, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
Hypertens Res 29:857-63. 2006..Measurement Evaluation (J-HOME) study, we examined the current situation with respect to the prescription of diuretics, including the prevalence of diuretic treatment and the dosages used for patients with essential hypertension in ..
- Antihypertensive efficacy and tolerability of candesartan-hydrochlorothiazide 32/12.5 mg and 32/25 mg in patients not optimally controlled with candesartan monotherapyGerd Bönner
MEDIAN Kliniken, Bad Krozingen, Germany
Blood Press Suppl 2:22-30. 2008..To evaluate the efficacy and tolerability of candesartan cilexetil 32 mg in combination with hydrochlorothiazide (HCT) 12.5 mg or 25 mg in hypertensive patients not optimally controlled with candesartan monotherapy...
- Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patientsToshio Ogihara
Osaka University Graduate School of Medicine, Osaka, Japan
Hypertens Res 32:163-7. 2009..Safety and tolerability will also be investigated. A total of more than 4000 patients were recruited and will be followed up for at least 3 years...
- Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled study with bumetanideLars Rejnmark
Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
J Bone Miner Res 21:163-70. 2006To study effects of loop diuretics on bone, 87 women were randomized to 1 year of treatment with bumetanide or placebo. Compared with placebo, bumetanide decreased BMD by 2% at the total hip and by 1.4% at the whole body...
- Changes in brain natriuretic peptide levels and bioelectrical impedance measurements after treatment with high-dose furosemide and hypertonic saline solution versus high-dose furosemide alone in refractory congestive heart failure: a double-blind studySalvatore Paterna
Department of Emergency Medicine, University of Palermo, Palermo, Italy
J Am Coll Cardiol 45:1997-2003. 2005..The aim of this study was to evaluate the effect of a new treatment for refractory congestive heart failure (CHF) on brain natriuretic peptide (BNP) plasma levels and hydration station...
- Antihypertensive therapiesRichard E T Smith
Nat Rev Drug Discov 6:597-8. 2007
- Renal effects of treatment with diuretics, octreotide or both, in non-azotemic cirrhotic patients with ascitesGeorgios Kalambokis
Department of Internal Medicine, Medical School of Ioannina, 45110 Ioannina, Greece
Nephrol Dial Transplant 20:1623-9. 2005..with renal dysfunction in cirrhotic patients with ascites, and in turn prevents the use of high doses of diuretics. Furthermore, ample evidence suggests that octreotide can inhibit the activation of the renin-aldosterone axis...
- Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)Mahboob Rahman
Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
Arch Intern Med 165:936-46. 2005....
- Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox statusD Sankar
Department of Biotechnology, Aarupadai Veedu Institute of Technology, Vinayaka Mission s Research Foundation University, Paiyanoor 603104, Chennai, Tamilnadu, India
Yale J Biol Med 79:19-26. 2006..investigate the effect of sesame oil in hypertensive patients who were on antihypertensive therapy either with diuretics (hydrochlorothiazide) or Beta-blockers (atenolol)...
- Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamidesClaudiu T Supuran
Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
Curr Pharm Des 14:641-8. 2008The widely clinically used benzothiadiazines and high ceiling diuretics, such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide, contain SO(2)NH(2) moieties acting ..
- Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-mediated apoptosisSandeep C Pingle
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
J Biol Chem 279:43157-67. 2004Osmotic diuretics are used successfully to alleviate acute tubular necrosis (ATN) produced by chemotherapeutic agents and aminoglycoside antibiotics...
- Continuous haemodynamic monitoring during withdrawal of diuretics in patients with congestive heart failureF Braunschweig
Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
Eur Heart J 23:59-69. 2002....
- Effects of ULTRAfiltration vs. DIureticS on clinical, biohumoral and haemodynamic variables in patients with deCOmpensated heart failure: the ULTRADISCO studyCristina Giglioli
Department of Heart and Vessels, Viale Morgagni, 85, Florence, Italy
Eur J Heart Fail 13:337-46. 2011To evaluate the clinical, biohumoral, and haemodynamic effects of ultrafiltration vs. intravenous diuretics in patients with decompensated heart failure (HF)...
- Rapid optimization: strategies for optimal care of decompensated congestive heart-failure patients in the emergency departmentW Frank Peacock
Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Rev Cardiovasc Med 3:S41-8. 2002....
- Attenuated renal excretion in response to thiazide diuretics in Gitelman's syndrome: a case reportChung Ho Yeum
Department of Internal Medicine, Cheju National University Medical School, Jeju, Korea
J Korean Med Sci 17:567-70. 2002..The administration of thiazide diuretics may induce a subnormal increase of urinary Na+ and Cl- excretion in patients with Gitelman's syndrome, ..
- Diuretics in clinical practice. Part II: electrolyte and acid-base disorders complicating diuretic therapyPantelis A Sarafidis
Section of Nephrology and Hypertension, 1st Department of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, St Kiriakidi 1, 54636, Thessaloniki, Greece
Expert Opin Drug Saf 9:259-73. 2010....
- Initial experience with fenoldopam after cardiac surgery in neonates with an insufficient response to conventional diureticsJohn M Costello
Division of Cardiac Intensive Care, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Pediatr Crit Care Med 7:28-33. 2006..We hypothesized that urine output would improve when fenoldopam was added to conventional diuretic therapy after neonatal cardiopulmonary bypass...
- Gout, diuretics and the kidneyE Pascual
Ann Rheum Dis 65:981-2. 2006
- Interactions of human organic anion transporters with diureticsHabib Hasannejad
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
J Pharmacol Exp Ther 308:1021-9. 2004The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs...
- Potassium-sparing diureticsJ D Horisberger
Yale University School of Medicine, Department of Physiology, New Haven, Conn
Ren Physiol 10:198-220. 1987Amiloride, triamterene, and the spirolactones are potassium-sparing diuretics which act on the distal parts of the nephron, from the late distal tubule to the collecting duct...
- Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive AgentsM R Lakshman
Lipid Research Laboratory, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
Arch Intern Med 159:551-8. 1999..Concern based on the reported short-term adverse effects of antihypertensive agents on plasma lipid and lipoprotein profiles (PLPPs) has complicated the therapy for hypertension...
- Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significanceMarco Metra
Section on Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia, Italy
Eur J Heart Fail 10:188-95. 2008..Renal function is a powerful prognostic variable in patients with heart failure (HF). Hospitalisations for acute HF (AHF) may be associated with further worsening of renal function (WRF)...
- Adverse prognostic significance of new diabetes in treated hypertensive subjectsPaolo Verdecchia
Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
Hypertension 43:963-9. 2004..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes...
- A propensity-matched study of the effects of chronic diuretic therapy on mortality and hospitalization in older adults with heart failureAli Ahmed
University of Alabama at Birmingham, and Veterans Affairs Medical Center, Birmingham, 1530 3rd Avenue South, CH19 219, Birmingham, Alabama 35294 2041, USA
Int J Cardiol 125:246-53. 2008Non-potassium-sparing diuretics may increase mortality and hospitalizations in heart failure patients...
- [IQWIG Preliminary Report: Diuretics are the best antihypertensives. How does it go on with the high blood pressure therapy? (interview)]Peter Sawicki
MMW Fortschr Med 149:6-8. 2007
- Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusionNatarajan Aravindan
Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University, Durham, North Carolina, USA
Ren Fail 28:25-35. 2006Loop diuretics are known to affect renal hemodynamics and possibly gene transcription, but the specific effect of furosemide on renal angiogenesis gene expression after acute ischemia is not known...
- CELLULAR CALCIUM TRANSPORT IN URINARY EPITHELIAPeter Friedman; Fiscal Year: 2003..We will: 1) Test the hypothesis that thiazide diuretics can inhibit Na+/Ca2+ exchange; and 2) Characterize the stimulatory effects of PTH on Na+/Ca2+ exchange...
- Hypertension PharmacogeneticsJulie Johnson; Fiscal Year: 2006..of verapamil, and will significantly further our understanding of the pharmacogenetics of p-blockers, thiazide diuretics, and ACE inhibitors...
- RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSDouglas Kiel; Fiscal Year: 1993..for this change in BMD will include weight, physical activity (leisure), caffeine, smoking, alcohol, thiazide diuretics, testosterone levels, dietary calcium, 25 hydroxy-vitamin D levels and thyroid hormone replacement and hormone ..
- Pharmacogenetics and Cardiovascular EventsBruce Psaty; Fiscal Year: 2006..cardiovascular drugs: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, all classes of diuretics, alpha blockers, beta-blockers, central alpha agonists, calcium antagonists, and estrogens...
- REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSIONPeter Igarashi; Fiscal Year: 1999..the thick ascending limb of the loop of Henle and represents the site of action of the clinically important loop diuretics furosemide and bumetanide. Importantly, expression of Nkcc2 transcripts is only observed in the kidney...
- A Family Partnership Intervention for Heart FailureSandra Dunbar; Fiscal Year: 2009..urinary sodium), medication adherence to HF drugs including angiotensin converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ..
- REGULATION OF KAPPA OPIOID RECEPTORSLee Yuan Liu Chen; Fiscal Year: 2002..Kappa agonists may be useful as analgesics, water diuretics and antipruritic agents...
- Cellular Pharmacology of Kappa Opioid ReceptorLee Yuan Liu Chen; Fiscal Year: 2007..effects, including analgesia, dysphoria and water diuresis and kappa agonists may be useful as analgesics, water diuretics and antipruritic drugs...
- Combined Computational and Wet Lab Screening for Drugs Tested via OATsSanjay K Nigam; Fiscal Year: 2010..kidney, liver) of many common drugs (eg. antibiotics, antivirals, chemotherapeutics, NSAIDs, antihypertensives, diuretics)...
- CHARACTERIZATION OF INTESTINAL ABSORPTION OF VITAMIN B1HAMID SAID; Fiscal Year: 2003..renal disease patients, the elderly, in inborn errors of thiamine metabolism, and in long-term users of diuretics. Humans and other mammals can not synthesize thiamine, and thus, must obtain the vitamin from exogenous sources ..
- Uric Acid and Hypertension in African-AmericansRichard Johnson; Fiscal Year: 2007Thiazide diuretics are associated with many metabolic side effects including hyperuricemia, gout, insulin resistance, and hyperlipidemia. These very conditions are already highly prevalent in African-Americans...
- Treatment of Calcium Nephrolithiasis Sodium ThiosulfateJohn Asplin; Fiscal Year: 2006..for calcium nephrolithiasis that have been proven effective in prospective placebo controlled trials, thiazide diuretics, potassium citrate salts, and allopurinol...