diuretics

Summary

Summary: Agents that promote the excretion of urine through their effects on kidney function.

Top Publications

  1. ncbi Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
    Barry R Davis
    The University of Texas School of Public Health, Houston, TX 77030, USA
    Circulation 113:2201-10. 2006
  2. ncbi Diuretics: still essential drugs for the management of hypertension
    Flavio Danni Fuchs
    Servico de Cardiologia, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90 035 903, Porto Alegre, RS, Brazil
    Expert Rev Cardiovasc Ther 7:591-8. 2009
  3. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
  4. ncbi A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly
    Lindon M H Wing
    School of Medicine, Flinders University, Adelaide, Australia
    N Engl J Med 348:583-92. 2003
  5. ncbi WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
    Tetsuo Moriguchi
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Chiyoda, Tokyo 101 0062
    J Biol Chem 280:42685-93. 2005
  6. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
  7. pmc Determinations of renal cortical and medullary oxygenation using blood oxygen level-dependent magnetic resonance imaging and selective diuretics
    Lizette Warner
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Invest Radiol 46:41-7. 2011
  8. pmc Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study
    Francesco Lapi
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte Catherine Montreal, Quebec H3T 1E2, Canada
    BMJ 346:e8525. 2013
  9. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
  10. ncbi Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    Kenneth Jamerson
    Division of Cardiovascular Medicine, University of Michigan Health System, 24 Frank Lloyd Wright Dr, Lobby M, Ann Arbor, MI 48106, USA
    N Engl J Med 359:2417-28. 2008

Detail Information

Publications362 found, 100 shown here

  1. ncbi Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
    Barry R Davis
    The University of Texas School of Public Health, Houston, TX 77030, USA
    Circulation 113:2201-10. 2006
    ..The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF...
  2. ncbi Diuretics: still essential drugs for the management of hypertension
    Flavio Danni Fuchs
    Servico de Cardiologia, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90 035 903, Porto Alegre, RS, Brazil
    Expert Rev Cardiovasc Ther 7:591-8. 2009
    According to most current international guidelines for hypertension, diuretics are indicated for elderly and black patients, unless they have any of a long list of other preferential indications...
  3. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
    ..Our results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures...
  4. ncbi A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly
    Lindon M H Wing
    School of Medicine, Flinders University, Adelaide, Australia
    N Engl J Med 348:583-92. 2003
    Treatment of hypertension with diuretics, beta-blockers, or both leads to improved outcomes. It has been postulated that agents that inhibit the renin-angiotensin system confer benefit beyond the reduction of blood pressure alone...
  5. ncbi WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
    Tetsuo Moriguchi
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Chiyoda, Tokyo 101 0062
    J Biol Chem 280:42685-93. 2005
    ..clue to the pathophysiology of pseudohypoaldosteronism type II was its striking therapeutic response to thiazide diuretics, which are known to block the sodium chloride cotransporter (NCC)...
  6. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
    ..angiotensin-converting-enzyme [ACE] inhibitors, calcium antagonists, angiotensin-receptor blockers [ARBs], and diuretics or beta blockers) or those targeting different blood pressure goals, on the risks of major cardiovascular events ..
  7. pmc Determinations of renal cortical and medullary oxygenation using blood oxygen level-dependent magnetic resonance imaging and selective diuretics
    Lizette Warner
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Invest Radiol 46:41-7. 2011
    ..Therefore, the adjunct use of diuretics that inhibit Na reabsorption selectively in PT and TAL, Az and furosemide, respectively, may help discern ..
  8. pmc Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study
    Francesco Lapi
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte Catherine Montreal, Quebec H3T 1E2, Canada
    BMJ 346:e8525. 2013
    To assess whether a double therapy combination consisting of diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers with addition of non-steroidal anti-inflammatory drugs (NSAIDs) and the triple therapy ..
  9. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
    ..of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used...
  10. ncbi Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    Kenneth Jamerson
    Division of Cardiovascular Medicine, University of Michigan Health System, 24 Frank Lloyd Wright Dr, Lobby M, Ann Arbor, MI 48106, USA
    N Engl J Med 359:2417-28. 2008
    ....
  11. ncbi The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients
    Lisheng Liu
    Division of Hypertension, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China
    J Hypertens 23:2157-72. 2005
    ....
  12. ncbi Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial
    George L Bakris
    Hypertensive Diseases Unit, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Lancet 375:1173-81. 2010
    ..We assessed the effects of these drug combinations on progression of chronic kidney disease...
  13. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
    ..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
  14. ncbi Antihypertensive treatment and development of heart failure in hypertension: a Bayesian network meta-analysis of studies in patients with hypertension and high cardiovascular risk
    Sebastiano Sciarretta
    Department of Cardiology, Second Faculty of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Arch Intern Med 171:384-94. 2011
    ..It is still debated whether there are differences among the various antihypertensive strategies in heart failure prevention. We performed a network meta-analysis of recent trials in hypertension aimed at investigating this issue...
  15. ncbi A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension
    Arnfried U Klingbeil
    Department of Medicine IV, University of Erlangen Nurnberg, Nuremberg, Germany
    Am J Med 115:41-6. 2003
    ..Antihypertensive medications have different effects on left ventricular mass. We conducted a meta-analysis of double-blind trials that measured the effects of antihypertensive therapy on left ventricular mass...
  16. ncbi Combination therapy in hypertension
    Alan H Gradman
    The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania and Temple University School of Medicine, Philadelphia, PA 15224, USA
    J Am Soc Hypertens 4:42-50. 2010
    ..The advantages and disadvantages of single pill (fixed) drug combinations, and the implications of recent clinical trials involving specific combination strategies will also be discussed...
  17. ncbi The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects
    H Knauf
    Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
    Eur J Clin Pharmacol 62:885-92. 2006
    Thiazide diuretics are known to induce a transient fall of the glomerular filtration rate (GFR), which, in turn, reduces tubular Na(+) load. This tubuloglomerular feedback (TGF) curtails the natriuretic effect of this class of diuretics...
  18. ncbi Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study
    Liyuan Ma
    Department of Evidence Based Medicine, Cardiovascular Institute, Beijing, China
    Am J Cardiovasc Drugs 12:137-42. 2012
    ....
  19. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
    ....
  20. ncbi Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    Stevo Julius
    University of Michigan, Ann Arbor, USA
    Lancet 363:2022-31. 2004
    ....
  21. ncbi Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Galter 10 240, 201 E Huron Street, Chicago, IL 60611, USA
    Eur Heart J 28:980-8. 2007
    ..The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure...
  22. ncbi The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP
    Pablo Cabrero
    IBLS Division of Molecular Genetics, University of Glasgow, UK
    J Exp Biol 205:3799-807. 2002
    ..These cells also express receptors for leucokinin, another major diuretic peptide, implying that the cells may be important in homeostatic regulation...
  23. ncbi Current status of antihypertensive prescription and associated blood pressure control in Japan
    Hisao Mori
    Japanese Medical and Dental Practitioners for the Improvement of Medical Care, Tokyo, Japan
    Hypertens Res 29:143-51. 2006
    ..6%) prescribed component of such therapy. Prescriptions of beta-blockers (BBs) decreased and those of CCBs and diuretics (D) increased with age (p<0.001)...
  24. pmc SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction
    Sung Sen Yang
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Am Soc Nephrol 21:1868-77. 2010
    ..In summary, SPAK-null mice have defects of NCC in the kidneys and NKCC1 in the blood vessels, leading to hypotension through renal salt wasting and vasodilation. SPAK may be a promising target for antihypertensive therapy...
  25. pmc Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive rats
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    PLoS ONE 7:e39162. 2012
    ....
  26. ncbi Systematic review: antihypertensive drug therapy in black patients
    Lizzy M Brewster
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 141:614-27. 2004
    ..Hypertension occurs more frequently and is generally more severe in black persons than in white persons, leading to excess morbidity and mortality...
  27. ncbi Adverse prognostic significance of new diabetes in treated hypertensive subjects
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
    Hypertension 43:963-9. 2004
    ..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes...
  28. ncbi The exact distribution of Cochran's heterogeneity statistic in one-way random effects meta-analysis
    Brad J Biggerstaff
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Stat Med 27:6093-110. 2008
    ..The methodology is illustrated by revisiting a recent simulation study concerning the heterogeneity measures and applying all the proposed methods to four published meta-analyses...
  29. ncbi A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 33:1681-7. 2005
    ..Albumin with furosemide benefits lung physiology in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome, but the independent pharmacologic effects of these drugs are unknown...
  30. ncbi ACE inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension
    T O Morgan
    Department of Physiology, University of Melbourne, Victoria, Australia
    Am J Hypertens 14:241-7. 2001
    ..placebo; angiotensin converting enzyme inhibitors; beta-blocking drugs; calcium-blocking drugs; and thiazide diuretics. Blood pressure (BP) was measured 24 to 26 h after the previous dose...
  31. ncbi Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensive
    A E Consolini
    Cátedra de Farmacodinamia, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
    J Ethnopharmacol 66:33-9. 1999
    ..Myrtaceae) is mostly due to a hypotensive effect mediated by a direct vasodilating activity, and to a weak diuretic effect that could be related to an increase in renal blood flow...
  32. ncbi Elevated N-terminal pro-brain natriuretic peptide levels predict an enhanced anti-hypertensive and anti-proteinuric benefit of dietary sodium restriction and diuretics, but not angiotensin receptor blockade, in proteinuric renal patients
    Maartje C J Slagman
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:983-90. 2012
    ..e. low sodium diet (LS) and/or diuretics] for optimal efficacy. However, both under- and overtitration of sodium targeting can easily occur...
  33. pmc Diuretic use, increased serum urate levels, and risk of incident gout in a population-based study of adults with hypertension: the Atherosclerosis Risk in Communities cohort study
    Mara A McAdams Demarco
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21287, USA
    Arthritis Rheum 64:121-9. 2012
    ..To quantify the role of diuretic use in gout development in an adult population with hypertension...
  34. pmc What differentiates primary care physicians who predominantly prescribe diuretics for treating mild to moderate hypertension from those who do not? A comparative qualitative study
    Christian M Rochefort
    Clinical and Health Informatics Research Group, Department of Medicine, Biostatistics and Occupational Health, McGill University and McGill University Health Center, 1140 Pine Avenue West, Montreal, QC, H3A 1A3, Canada
    BMC Fam Pract 13:9. 2012
    Thiazide diuretics are cost-effective for the treatment of mild to moderate hypertension, but physicians often opt for more expensive treatment options such as angiotensin II receptor blockers or angiotensin converting enzyme inhibitors...
  35. ncbi Diuretics for Ménière's disease or syndrome
    A S Thirlwall
    Royal Berkshire Hospital, Ear, Nose and Throat Department, London Road, Reading, UK RG1 5AN
    Cochrane Database Syst Rev 3:CD003599. 2006
    Ménière's disease is a disorder characterised by hearing loss, tinnitus and disabling vertigo. Diuretics are used to try and reduce the severity and frequency of episodes but there is little evidence behind this treatment.
  36. ncbi Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics
    Sergio da Cunha
    Hospital Universitario Pedro Ernesto, IBRAG, Geologia UERJ, Rio de Janeiro, RJ, Brazil
    Arq Bras Cardiol 79:454-65. 2002
    ..the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease.
  37. ncbi Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial
    Augustine N Odili
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press 20:256-66. 2011
    ....
  38. ncbi Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene
    Khalid Hussain
    London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
    J Pediatr 146:706-8. 2005
    ..This mutation resulted in a nearly complete absence of immunoreactive protein and a decrease in fibroblast SCHAD activity...
  39. pmc Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial
    Femke Waanders
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 53:16-25. 2009
    ..We hypothesized that a decrease in proteinuria by using therapeutic interventions is associated with decreased urinary KIM-1 levels...
  40. ncbi Diuretics and bone loss in rats with aldosteronism
    Peter H Law
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Am Coll Cardiol 46:142-6. 2005
    ..We hypothesized that the increased urinary Ca2+ and Mg2+ excretion and bone loss that accompanies aldosteronism is aggravated with furosemide and is attenuated by spironolactone...
  41. pmc The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis
    Amy B Cadwallader
    Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti, 1, Rome, Italy
    Br J Pharmacol 161:1-16. 2010
    b>Diuretics are drugs that increase the rate of urine flow and sodium excretion to adjust the volume and composition of body fluids...
  42. ncbi Reappraisal of the role of diuretics in heart failure
    Maya Guglin
    University of South Florida, Tampa, USA
    Cardiol Rev 17:56-9. 2009
    The focus of this review is to explore the controversy between the broad acceptance of loop diuretics as a first-line treatment for heart failure (HF) and the data regarding their association to increased morbidity and mortality in HF...
  43. ncbi Hydrochlorothiazide versus chlorthalidone in the management of hypertension
    Kimberly M Neff
    New Mexico VA Health Care System, Albuquerque, NM, USA
    Cardiol Rev 18:51-6. 2010
    Thiazide diuretics are a mainstay for the treatment of hypertension...
  44. ncbi Pediatric idiopathic intracranial hypertension
    Lubaina M Rangwala
    Neuro ophthalmology Services of the Children s Hospital of Philadelphia, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Surv Ophthalmol 52:597-617. 2007
    ....
  45. pmc The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus
    Tero Viitanen
    Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
    J Physiol 588:1527-40. 2010
    ..Our findings reveal a novel excitatory mode of action of KCC2 that can have substantial implications for the role of GABAergic transmission during ictal epileptiform activity...
  46. ncbi Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
    Anushka Patel
    Cardiovascular Division, The George Institute for International Health, University of Sydney, PO Box M201, Missenden Road, Sydney, NSW 2050, Australia
    Lancet 370:829-40. 2007
    ....
  47. ncbi Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, 19 1 Uchimaru, Morioka 020 8505, Iwate, Japan
    Clin Sci (Lond) 102:381-6. 2002
    ..In addition, CYP11B2 expression and cardiac fibrosis are found to be decreased in CHF patients on drug therapy comprising spironolactone combined with ACEIs...
  48. ncbi C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diuretic
    S T Turner
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Hypertension 37:739-43. 2001
    ..Thus, the C825T polymorphism of the G protein beta(3)-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy...
  49. ncbi Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction
    A Monroy
    Molecular Physiology Unit, Instituto Nacional de la Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, National University of Mexico, Tlalpan 14000 Mexico City, Mexico
    Am J Physiol Renal Physiol 279:F161-9. 2000
    ..Both ion binding sites alter thiazide-mediated inhibition of transport, indicating that the thiazide-binding site is either shared or modified by both Na(+) and Cl(-)...
  50. ncbi Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats
    K H Reid
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
    Brain Res 864:134-7. 2000
    The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter ..
  51. ncbi Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial
    Peter H J van der Voort
    Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:533-8. 2009
    ..To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients...
  52. ncbi Herbal medicines as diuretics: a review of the scientific evidence
    C I Wright
    Nutrition, Nutrition and Health Enhancement, Unilever Food and Health Research Institute, Olivier van Noortlaan 120, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
    J Ethnopharmacol 114:1-31. 2007
    ..e., hypertension). One class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as well as the amount of sodium in urine...
  53. ncbi Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytes
    Brian A MacVicar
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Glia 37:114-23. 2002
    ..In summary, these results indicated that KCl uptake into astrocytes via an Na-K-2Cl cotransporter during raised [K(+)](o) contributes to the generation of cellular swelling and the intrinsic optical signals...
  54. pmc Nephrotoxicity in the elderly due to co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs
    V Adhiyaman
    Department of Geriatric Medicine, Wrexham Maelor Hospital, Wrexham LL13 7TD, Wales, UK
    J R Soc Med 94:512-4. 2001
    ..remained stable in 6 patients: patients with deterioration in renal function were older and more likely to be on diuretics. This drug combination is commonly nephrotoxic in the elderly and should be avoided, especially in those taking ..
  55. ncbi Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Thiazide diuretics are frequently used in these patients for treatment of hypertension, but they also exacerbate metabolic syndrome...
  56. ncbi Impact of angiotensin receptor blockade in combination with hydrochlorothiazide 25 mg in 2121 patients with stage 1-2 hypertension
    W B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    J Hum Hypertens 23:817-25. 2009
    ..The magnitude of the BP-lowering effect provides support for the use of angiotensin receptor blockers with higher doses of a thiazide diuretic (25 mg) to improve hypertension control...
  57. ncbi Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia
    S Reungjui
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Kidney Int 72:1483-92. 2007
    ..We also found impaired endothelium-dependent vasorelaxation was linked to mild hypokalemia...
  58. pmc The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    J Physiol 558:147-59. 2004
    ..VR-1 knockout mice demonstrate no functional amiloride-insensitive salt taste receptor and no salt taste sensitivity to vanilloids and temperature. We conclude that the mammalian non-specific salt taste receptor is a VR-1 variant...
  59. ncbi A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    JAMA 290:2805-16. 2003
    ..Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials...
  60. ncbi Furosemide and mannitol suppression of epileptic activity in the human brain
    Michael M Haglund
    Department of Surgery Neurosurgery and Neurobiology, Durham, NC 27710, USA
    J Neurophysiol 94:907-18. 2005
    ..Furosemide and other drugs that modulate the ECS might possess clinically useful antiepileptic properties, while avoiding the side effects associated with the suppression of neuronal excitability...
  61. ncbi Cystoid macular edema with docetaxel chemotherapy and the fluid retention syndrome
    David G Telander
    Department of Ophthalmology, University of California, Davis, Sacramento, CA, USA
    Semin Ophthalmol 22:151-3. 2007
    ..Successful management of CME with oral acetazolamide is also discussed...
  62. ncbi Use of diuretics and risk of implant failure after primary total hip arthroplasty: a nationwide population-based study
    Theis M Thillemann
    Department of Orthopedics, Aarhus University Hospital, Denmark
    Bone 45:499-504. 2009
    Thiazid and loop diuretics have been associated with changes in bone mineral density and fracture risk. However, data on survival of prosthesis implants are lacking...
  63. ncbi High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial
    Felix Cantarovich
    Department of Transplantation and Intensive Care, Necker Hospital, Paris, France
    Am J Kidney Dis 44:402-9. 2004
    ..The effect of furosemide on the survival and renal recovery of patients presenting with acute renal failure (ARF) is still debated...
  64. pmc Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site
    Elton Migliati
    Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia
    Mol Pharmacol 76:105-12. 2009
    ..The identification of AQP-selective pharmacological agents opens opportunities for breakthrough strategies in the treatment of edema and other fluid imbalance disorders...
  65. pmc Partial resolution of diabetic macular oedema after systemic treatment with furosemide
    A P Ciardella
    Br J Ophthalmol 88:1224-5. 2004
  66. ncbi Diuretic use, residual renal function, and mortality among hemodialysis patients in the Dialysis Outcomes and Practice Pattern Study (DOPPS)
    Jennifer L Bragg-Gresham
    Arbor Research Collaborative for Health, formerly University Renal Research and Education Association, Ann Arbor, MI, USA
    Am J Kidney Dis 49:426-31. 2007
    ..Information about residual renal function (RRF) and outcomes associated with practices of diuretic use in patients with end-stage renal disease is not available worldwide...
  67. ncbi Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 32:962-8. 2009
    ..These properties may provide cardiovascular protection in addition to the hypotensive effect...
  68. ncbi Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamide
    Rikke Søgaard
    Nordic Centre for Water Imbalance Related Disorders, Institute of Cellular and Molecular Medicine, Blegdamsvej 3C, University of Copenhagen, Blegdamsvej 3C, DK 2200, Copenhagen N, Denmark
    Pflugers Arch 456:285-92. 2008
    ..These parameters may vary between laboratories...
  69. ncbi Risk factors for thiazide-induced hyponatraemia
    K M Chow
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    QJM 96:911-7. 2003
    ..Thiazide-induced hyponatraemia is common and potentially life threatening. In the absence of well-defined risk factors for this complication, guidelines for prescribing cannot be established...
  70. ncbi Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazide
    Patrícia Guerrero
    Graduate Study Program in Health Sciences Cardiology, Universidade Federal do Rio Grande do Sul UFRGS, Brazil
    Clin Exp Hypertens 30:553-64. 2008
    ..Cough, albeit predominantly mild, was reported more frequently by participants treated with enalapril. We conclude that enalapril is more effective than amiloride to lower BP of patients on hydrochlorothiazide with uncontrolled BP...
  71. ncbi The Hong Kong diastolic heart failure study: a randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fraction
    G W K Yip
    Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    Heart 94:573-80. 2008
    ..The effect of renin-angiotensin blockade by irbesartan or ramipril in combination with diuretics on quality of life (QoL), regional and global systolic and diastolic function was assessed in HFNEF patients.
  72. ncbi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    ..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  73. ncbi Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)
    M J Brown
    Clinical Pharmacology Unit, University of Cambridge, UK
    Lancet 356:366-72. 2000
    The efficacy of antihypertensive drugs newer than diuretics and beta-blockers has not been established...
  74. ncbi Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigators
    P S Sever
    Imperial College School of Medicine, London, UK
    J Hypertens 19:1139-47. 2001
    ..To test a second primary hypothesis that a statin compared with placebo will further protect against CHD endpoints in hypertensive subjects with a total cholesterol < or = 6.5 mmol/l...
  75. ncbi Rationale for angiotensin II receptor blockers in patients with low-renin hypertension
    K A Jamerson
    University of Michigan Medical Center, Ann Arbor, MI 48109 0357, USA
    Am J Kidney Dis 36:S24-30. 2000
    ..JNC VI) guidelines, antihypertensive monotherapy for African Americans is based on the known ability of diuretics and calcium channel blockers to produce greater reductions in blood pressure in this population than those ..
  76. ncbi Calcium antagonists in patients with type 2 diabetes and hypertension
    Samy I McFarlane
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Biochemistry, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 50, Brooklyn, NY 11203, USA
    Cardiovasc Drug Rev 21:105-18. 2003
    ....
  77. ncbi The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats
    Masami Uechi
    Veterinary Teaching Hospital, Kitasato University Higashi, Towada, Aomori, Japan
    J Vet Med Sci 65:1057-61. 2003
    ..These data suggest that torasemide is useful for treating congestive heart failure or edema in cats and dogs...
  78. pmc Clinical efficacy and safety of olmesartan/hydrochlorothiazide combination therapy in patients with essential hypertension
    Luis M Ruilope
    Unidad de Hipertension, Hospital 12 de Octubre, Madrid, Spain
    Vasc Health Risk Manag 4:1237-48. 2008
    ....
  79. ncbi Liquid chromatographic separation of the stereoisomers of thiazide diuretics
    M H Hyun
    Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, South Korea
    J Chromatogr A 876:221-7. 2000
    A number of racemic thiazide diuretics and analogues were resolved on two diastereomeric chiral stationary phases (CSPs) prepared from (S)- or (R)-alpha-[1-(6,7-dimethyl)naphthyl]-10-dodecenylamine and (S)-2-phenylpropanoic acid...
  80. ncbi Pattern of drug utilization among hypertensives in a Nigerian teaching hospital
    K B Yusuff
    Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Pharmacoepidemiol Drug Saf 14:69-74. 2005
    ..To describe the drug utilization pattern among hypertensive patients in a tertiary care setting, assess the short-term outcome of anti-hypertensive drugs usage and identify points for future intervention to improve outcomes...
  81. pmc Renal expression of parvalbumin is critical for NaCl handling and response to diuretics
    Hendrica Belge
    Department of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 104:14849-54. 2007
    ..plays an essential role in the reabsorption of NaCl by the kidney, a process that can be inhibited by thiazide diuretics. Parvalbumin (PV), a Ca(2+)-binding protein that plays a role in muscle fibers and neurons, is selectively ..
  82. ncbi Diuretics for hypertension
    Lawrence R Krakoff
    Englewood Hospital and Medical Center, Englewood, NJ 07631, USA
    Circulation 112:e127-9. 2005
  83. pmc Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study
    A Ø Jensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Br J Cancer 99:1522-8. 2008
    b>Diuretics have photosensitising properties. However, little is known about how these diuretics affect the risk of skin cancers...
  84. ncbi Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus
    Brooks B Pond
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    Neuropharmacology 47:253-62. 2004
    ....
  85. ncbi The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics
    Tetsutaro Matayoshi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:821-33. 2004
    The response of blood pressure to thiazide diuretics (TZDs) differs among individuals. The prediction of the antihypertensive effect of TZDs is important for realizing individualized therapy in the management of hypertension...
  86. doi Risk/benefit assessment of beta-blockers and diuretics precludes their use for first-line therapy in hypertension
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, 1000 10th Ave, Suite 3B 30, New York, NY 10019, USA
    Circulation 117:2706-15; discussion 2715. 2008
  87. ncbi Acute renal failure when exenatide is co-administered with diuretics and angiotensin II blockers
    Alfonso López-Ruiz
    Diabetes Unit, Reina Sofia University Hospital, 30003, Murcia, Spain
    Pharm World Sci 32:559-61. 2010
    ..This adverse effect could be caused by the co-administration of diuretics and angiotensin II receptor antagonists.
  88. pmc Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity
    Carol Hamelink
    Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulatiuon, National Institute of Mental Health NIH, Bldg 49, Room 5A 35, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Pharmacol Exp Ther 314:780-8. 2005
    ..Of the diuretics tested, furosemide was protective, whereas the other two anion exchanger inhibitors, L-644,711 [(R)-(+)-(5,6-..
  89. pmc Low doses of esmolol and phenylephrine act as diuretics during intravenous anesthesia
    Yu Hong Li
    Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, 310003 Hangzhou, China
    Crit Care 16:R18. 2012
    ..The renal clearance of infused crystalloid fluid is very low during anaesthesia and surgery, but experiments in conscious sheep indicate that the renal fluid clearance might approach a normal rate when the adrenergic balance is modified...
  90. ncbi Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics
    Wiebke Fenske
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 93:2991-7. 2008
    ..However, in hyponatremic patients taking diuretics, this definition is unreliable due to the natriuretic effect of diuretics...
  91. ncbi Thiazide diuretics enhance nocturnal blood pressure fall and reduce proteinuria in immunoglobulin A nephropathy treated with angiotensin II modulators
    Takashi Uzu
    Division of Nephrology, Osaka Rosai Hospital, Sakai, Osaka, Japan
    J Hypertens 23:861-5. 2005
    We examined whether thiazide diuretics could restore nocturnal blood pressure (BP) decline and reduce urinary protein excretion in patients with glomerulopathy treated with angiotensin II modulators (angiotensin-converting enzyme ..
  92. ncbi Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity
    Alessandra Cantone
    Dept of Cellular and Molecular Physiology, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520 8026, USA
    Am J Physiol Renal Physiol 294:F1366-72. 2008
    ..Moreover, hydrochlorothiazide increased the fractional K(+) excretion rate in Romk(-/-) mice, confirming our recent observation that maxi-K channels contribute to distal K(+) secretion in the absence of ROMK...
  93. ncbi Antihypertensive therapy and incidence of type 2 diabetes in an elderly cohort
    Raj Padwal
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Diabetes Care 27:2458-63. 2004
    ..The aim of this study was to determine whether the incidence of type 2 diabetes differed among elderly users of four major antihypertensive drug classes...
  94. ncbi Diuretics and salt transport along the nephron
    Paul L Bernstein
    Division of Nephrology, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    Semin Nephrol 31:475-82. 2011
    The clinical use of diuretics almost uniformly predated the localization of their site of action...
  95. ncbi The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure
    Ariel J Reyes
    Institute of Cardiovascular Theory, Sotelo 3908, 11700 Montevideo, Uruguay
    Eur J Heart Fail 7:461-7. 2005
    ..UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels worsening cardiac function also contributes to elevated serum UA ..
  96. pmc Back to thiazide-diuretics for hypertension: reflections after a decade of irrational prescribing
    Atle Fretheim
    Department of Health Services Research, Norwegian Directorate for Health and Social Affairs, N 0031 Oslo, Norway
    BMC Fam Pract 4:19. 2003
    ....
  97. ncbi Risk of intraoperative hypotension with loop diuretics: a randomized controlled trial
    Nadia A Khan
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med 123:1059.e1-8. 2010
    ..Whether loop diuretics also induce intraoperative hypotension is uncertain...
  98. ncbi Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker
    Takashi Uzu
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Clin Exp Nephrol 13:300-6. 2009
    ..Therefore, we examined the effects of the amount of sodium intake or diuretics in patients with diabetes treated with an angiotensin receptor blocker.
  99. ncbi The ALLHAT Trial. Diuretics are still the preferred initial drugs for high blood pressure
    Donald G Vidt
    Department of Nephrology and Hypertension, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 70:263-9. 2003
    ..The doxazosin arm was terminated early because of an excess of congestive heart failure. Chlorthalidone was at least equivalent to amlodipine and lisinopril in all of the outcomes measured, and was better in some, notably heart failure...
  100. ncbi All hats off to ALLHAT: a massive study with clear messages
    John Chalmers
    J Hypertens 21:225-8. 2003
  101. ncbi Diuretics in acute kidney injury
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 31:523-34. 2011
    ..A variety of interventions, including loop diuretics, have been tested for the prevention and treatment of AKI; however, none to date have shown convincing benefits ..

Research Grants64

  1. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..result in hypotension due to renal sodium wasting, and these transporters are the targets of thiazide and loop diuretics, respectively. Knockout of the KCC4 gene in mice results in distal renal tubular acidosis...
  2. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..and the BP set point, generating a sodium avid phenotype that may be amenable to correction with thiazide diuretics. Interestingly, the STK39 genotypes associated with higher BP are also associated with lower fasting glucose, ..
  3. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
    ..controlled when transporter function is carefully modulated, as by a wide range of drugs in clinical use today (diuretics, antihypertensives, antidepressants and many others)...
  4. Analysis of distal conboluted tubule function in vivo
    James A McCormick; Fiscal Year: 2012
    ..PHAII is remediable by treatment with thiazide diuretics, which specifically inhibit NCC...
  5. Comparative safety &effectiveness of antihypertensive medications in pregnancy
    BRIAN THOMAS BATEMAN; Fiscal Year: 2013
    ..to assure a good pregnancy outcome?" We will also examine the safety of first trimester exposure to thiazide diuretics and angiotensin converting enzyme inhibitors, which are the most common types of antihypertensives used in women ..
  6. Combined Computational and Wet Lab Screening for Drugs Tested via OATs
    Sanjay K Nigam; Fiscal Year: 2010
    ..kidney, liver) of many common drugs (eg. antibiotics, antivirals, chemotherapeutics, NSAIDs, antihypertensives, diuretics)...
  7. Heat Waves, Medication Use, and Adverse Health Outcomes Among Older Adults
    SOKO SETOGUCHI-IWATA; Fiscal Year: 2013
    ..The drug categories of interest include antipsychotics, antidepressants, stimulants, diuretics, antihypertensive drugs, antiepileptic drugs, anti-Parkinson drugs, lipid-lowering agents, and other medications ..
  8. Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
    William F Weitzel; Fiscal Year: 2013
    ..Management of patients with diuretics or extracorporeal therapies requires proper assessment of volume status...
  9. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2012
    ..blockers;4) angiotensin converting enzyme inhibitors;5) angiotensin receptor blockers;6) direct vasodilators;7) diuretics and 8) central alpha blockers...
  10. Integrating plasma IGF-1 into novel classification of hepatocellular carcinoma
    Ahmed Kaseb; Fiscal Year: 2013
    ..to grade, may be precipitated by other nonliver diseases, and may vary in severity according to treatment with diuretics and lactulose...
  11. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2009
    ..urinary sodium), medication adherence to HF drugs including angiotensin converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ..
  12. Pharmacogenomic Evaluation of Antihypertensive Responses
    Julie A Johnson; Fiscal Year: 2013
    ..death, stroke, heart attack, diabetes) to two commonly prescribed classes of antihypertensive drugs, thiazide diuretics and p-blockers...
  13. Role of Collecting Duct Chloride Transporters in Volume Regulation
    Manoocher Soleimani; Fiscal Year: 2013
    ..absorption in the collecting duct in response to increased delivery of salt to the distal nephron caused by diuretics. Lastly and continuing with the proposed studies in our existing Merit Review award, we report the generation of ..
  14. Central Kappa Opioid Neural Regulation of Cardiovascular and Renal Function
    Helmut B Gottlieb; Fiscal Year: 2012
    ..in urine flow without a concurrent increase in renal sodium excretion), which is different than traditional diuretics clinically used to date (which, enhance water and sodium excretion)...
  15. Impact of neuronal chloride transport on treatment of seizures.
    Kevin J Staley; Fiscal Year: 2013
    ..The hypotheses also predict that clinically available diuretics and inhibitors of cytoskeletal changes might also be useful in the treatment of status epilepticus in both ..
  16. Role of Eicosanoids in Renal Function
    NANCY JOAN BROWN; Fiscal Year: 2013
    ..AA epoxidation/hydroxylation, and individual responses to changes in dietary salt intake, the administration of diuretics, or peroxisomal proliferator activated receptor (alpha) ligands...
  17. Membrane Trafficking of Renal Ion Transport Proteins in Potassium Homeostasis
    Chou Long Huang; Fiscal Year: 2013
    ..electrolytes and expression of Na+ and K+ transporters in response to dietary Na+ or K+ perturbations and to diuretics. K+ secretion will also be studied by in vitro microperfusion of isolated CCD tubules...
  18. Data Infrastructure for Post-Marketing Comparative Effectiveness Studies
    SEAN P HENNESSY; Fiscal Year: 2010
    ..of different strategies for initial supplementation and monitoring of potassium in patients newly starting loop diuretics and those newly starting thiazide diuretics with regard to preventing 1) all-cause death and 2) sudden cardiac ..
  19. GRK4 and development of salt sensitivity
    Pedro A Jose; Fiscal Year: 2012
    ..b>Diuretics are more effective in lowering blood pressure in individuals with variants of this gene...
  20. Biventricular Pacing in Heart Failure
    SAMIR FAWZI SABA; Fiscal Year: 2010
    ..pharmacologic therapy including angiotensin converting enzyme inhibitors, b-blockers, and potassium-sparing diuretics can extract benefits from BIV pacing in the form of improved maximum oxygen consumption, exercise tolerance, and ..
  21. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2010
    ..angiotensin converting enzyme inhibitors;5) angiotensin receptor blockers;6) direct vasodilators;and 7) diuretics)...
  22. Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
    Amanda Hyre Anderson; Fiscal Year: 2013
    ..inadequate control of blood pressure, elevated body mass index, and use of renin- angiotensin-system blockade, diuretics, and nonsteroidal anti-inflammatory drugs as modifiable risk factors for AKI in the setting of CKD, 2) to ..
  23. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    Loop diuretics are widely used to treat premature infants in neonatal intensive care units. Recent reports have suggested an increased risk of permanent sensorineural hearing loss among infants receiving such treatments...
  24. Regulation of Renal Hemodynamics by Adenosine Mediated Coincident Signaling
    Jonathan D Verrier; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diuretics are used as a pharmacological therapeutic intervention in diseases including hypertension, heart failure, liver dysfunction and chronic kidney disease...
  25. Binge alcohol-induced neurodegeneration and omega-3 DHA Protection
    Michael A Collins; Fiscal Year: 2012
    ..mM) cause hippocampal/cortical neurodegeneration that (a) is not typically excitotoxic;(b) entails brain edema (diuretics prevent the edema and neurodamage);(c) involves oxidative stress (antioxidants neuroprotect);and (d) requires ..
  26. Cardio-renal phenotype and prognosis in chronic heart failure
    Jeffrey M Testani; Fiscal Year: 2012
    ..Severe HF and its treatment (i.e., loop diuretics) are known to result in progressive neurohormonal activation and peripheral organ dysfunction (i.e., RD)...
  27. Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium
    Bruce M Psaty; Fiscal Year: 2013
    ..antihistamines, antibiotics, and antidepressants);(2) sulfonylurea anti-diabetic agents;(3) thiazide diuretics, and (4) tri-cyclic and tetra- cyclic anti-depressants...
  28. Human Cardiorenal Syndrome
    Horng H Chen; Fiscal Year: 2013
    ..b>Diuretics are effective and necessary to relieve congestion in CHF however recent reports have suggested potential ..
  29. Management and Outcomes of Heart Failure with Preserved Systolic Function
    Alan S Go; Fiscal Year: 2010
    ..g., diuretics, digoxin, nitrates, and statins). The public health burden for chronic heart failure is substantial-affecting 5...
  30. Adenosine in Renal Sympathetic Neurotransmission
    EDWIN KERRY JACKSON; Fiscal Year: 2013
    ..and inform renal physiologists working in all aspects of renal function and dysfunction and would provide a strong rationale for using A1 receptor blockers as diuretics in conditions associated with increased renal sympathetic tone.
  31. EXTENDED RELEASE TORSEMIDE
    CHRISTOPHER WILCOX; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diuretics are the most widely prescribed class of drugs...
  32. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    ..of verapamil, and will significantly further our understanding of the pharmacogenetics of p-blockers, thiazide diuretics, and ACE inhibitors...
  33. Mouse Models for Ion Homeostasis Defects in Heart
    Gary E Shull; Fiscal Year: 2010
    ..Some of this information has important clinical implications, particularly with regard to metabolic abnormalities, including insulin resistance, in heart disease and adverse effects of loop diuretics.
  34. Comparative Effectiveness of ACE Inhibitors for African Americans
    GBENGA GODWIN OGEDEGBE; Fiscal Year: 2011
    ..outcomes: 1) more often in African Americans compared to Caucasians;2) more often than !-blockers, thiazide diuretics, or calcium channel blockers among nondiabetic African Americans;and 3) the incremental cost-effectiveness of ..
  35. Systems Biology of Anionic Drug and Metabolite Handling
    Sanjay K Nigam; Fiscal Year: 2012
    Many commonly prescribed anionic drugs (eg. antibiotics, diuretics, ACE inhibitors, NSAIDs) as well as disease-associated metabolites are organic anions that are excreted as a result of transport by the proximal tubule of the kidney...
  36. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
    ..cardiovascular drugs: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, all classes of diuretics, alpha blockers, beta-blockers, central alpha agonists, calcium antagonists, and estrogens...
  37. Nanoaerosols from Wick Electrospray for Improved Drug Delivery to Infants
    P Worth Longest; Fiscal Year: 2013
    ..improved delivery efficiency to the lungs, reduced dose variability, and deposition within the entire airways of infants are of critical importance include the use of aerosolized surfactants, antibiotics, prostanoids, and diuretics.
  38. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..A similar trial of magnesium and potassium will be conducted in mild hypertensives who are being treated with diuretics since diuretics deplete Mg and K and the hypotensive effect of oral repletion may be potentiated...
  39. REGULATION OF THE NA+/K+ 2C1 COTRANSPORTER PROTEIN
    David Mount; Fiscal Year: 1999
    ..This protein is the pharmacological receptor for loop diuretics (furosemide, bumetanide and ethacrynic acid), and plays a pivotal role in renal physiology...
  40. CONTROL OF THE CIRCULATION DURING THERMAL STRESS
    DUANE PROPPE; Fiscal Year: 1991
    ..in removing the attenuation of the EH-produced cutaneous VD during dehydration (Aim #1) and administration of diuretics for 3 days (Aim #2). Dehydration will be produced by 64- 68 hours of oral fluid deprivation...
  41. TRACE ELEMENT NUTRITION OF THE LENS--ZINC
    J Bentley; Fiscal Year: 1990
    ..mellitus and diarrheal disease, and the use of some drugs such as ethanol, oral contraceptives and thiazide diuretics. Some such conditions are known to result in a predisposition to cataracts in humans...
  42. REGULATION OF KAPPA OPIOID RECEPTORS
    Lee Yuan Liu Chen; Fiscal Year: 2002
    ..Kappa agonists may be useful as analgesics, water diuretics and antipruritic agents...
  43. DIURETIC PROTECTION FROM ALCOHOL INDUCED BRAIN DAMAGE
    Michael Collins; Fiscal Year: 1999
    ..we propose in this R21 application to explore the generality of neuroprotection by studying three other diuretics, acetazolamide, chlorthalidone and torsemide along with a nondiuretic furosemide analog (L-644, 711) in our in ..
  44. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..for calcium nephrolithiasis that have been proven effective in prospective placebo controlled trials, thiazide diuretics, potassium citrate salts, and allopurinol...
  45. Insulin, Renal Sodium Transport and Blood Pressure
    Carolyn Ecelbarger; Fiscal Year: 2006
    ..NCC protein abundances with changes in rat blood pressure, and sensitivity to transporter or channel selective diuretics, i.e., amiloride and polythiazide...
  46. TOPICAL B-BLOCKER SIDE EFFECTS IN ELDERLY
    JEROME AVORN; Fiscal Year: 1990
    ..g. diuretics, digoxin, bronchodilators, antidepressants, etc.)...
  47. THE PHARMACOLOGY OF OMEGA-3 FATTY ACIDS
    HOWARD KNAPP; Fiscal Year: 1991
    ..Recently, it has been noted that treating hypertension with beta-blockers and diuretics has not yielded as great a reduction in cardiac risk as predicted...
  48. Modulators of CL-dependent Transport Processes (RMI)
    Eric Delpire; Fiscal Year: 2005
    ..In fact, the co-transporters are best known through their inhibitors: the loop and thiazide diuretics which are widely used in clinical medicine to volume deplete patients...
  49. MECHANISMS OF BRAIN DEHYDRATION WITH OSMOTIC DIURETICS
    Stanley Nelson; Fiscal Year: 1980
    The osmotic diuretics can be relied upon to reduce intracranial pressure in patients wth conditons such as brain tumors and cerebral trauma...
  50. Regulation of Na-CI cotransporter (NCC) subcellular distribution in DCT
    ALICIA MCDONOUGH; Fiscal Year: 2007
    ..NCC is the target of the thiazide diuretics prescribed very frequently for treatment of hypertension, edema and heart failure...
  51. DIURETICS, HYPERTENSION, AND ARRHYTHMIAS CLINICAL TRIAL
    Stephen Hulley; Fiscal Year: 1990
    ..measurements to compare the long term effects of prestudy diuretic regimens, 220 men were withdrawn from diuretics for a month of electrolyte supplementation and then randomized to 2 months of treatment with 1 of the following: ..
  52. CONTROL OF POTASSIUM TRANSPORT IN BLADDER
    PHILIP STEINMETZ; Fiscal Year: 1980
    ..to transport Na ion, Cl and H ion against steep concentration gradients and in its response to hormones and diuretics. It is the objective of the research to define the transcellular and paracellular flows of potassium and to ..
  53. A Systems Engineering Approach: Improving Medication Safety with Clinician Use of
    Gurdev Singh; Fiscal Year: 2009
    ..by evaluating changes in monitoring rates for subjects (age 65+) on: (a) ACE Inhibitors or ARBs;(b) Digoxin;(c) Diuretics;and (d) Statins...
  54. BEDSIDE SYSTEM FOR COMBINED RNA AND PACIN HEART FAILURE
    Jeffrey Lacy; Fiscal Year: 2001
    ..of such patients, including quantitative examination of the effects of interventions, such as dobutamine and IV diuretics, as well as assessments of response to therapeutic dose levels...
  55. STUDY FOR THE TREATMENT OF REFRACTORY ASCITES
    Arun Sanyal; Fiscal Year: 2000
    ..trial which will test the hypothesis that TIPS is more effective than "standard therapy (TP/Na restriction /diuretics)" for refractory ascites...
  56. Inhaled Loop Diuretics for Congestive Heart Failure
    Daniel Myers; Fiscal Year: 2004
    ..Although these symptoms are currently generally treated by oral loop diuretics, intravenous (IV) delivery of loop diuretics provides more rapid and complete relief, with many hospital visits ..
  57. CARDIAC GLYCOSIDES AND DIURETICS: ROLE OF NA+ PUMP
    SHAILESH BANERJEE; Fiscal Year: 1980
    ....
  58. ATRIAL PEPTIDES IN NORMAL AND HYPERTENSIVE PREGNANCY
    Marshall Lindheimer; Fiscal Year: 1990
    ..to volume manipulation (chronically: high or low Na diets, mineralocorticoids: acutely: saline loads or diuretics) include: a) Measurement of plasma and atrial ANP, the mRNA of ANP's preprohormone in the atrium, and other ..
  59. INHALED NO IN PREVENTION OF CHRONIC LUNG DISEASE
    Scott Lorch; Fiscal Year: 2004
    ..in conjunction with corticosteroids, postnatal steroid administration, as well as administration of Vitamin E, diuretics, and bronchodilators, have not resulted in clinically important decreases in CLD...
  60. GENERAL CLINICAL RESEARCH CENTER
    Paul Calabresi; Fiscal Year: 1990
    ..aging and parathyroid function in normal and osteopenic subjects; mechanisms of the antihypertensive action of diuretics; and the use of redioenhancing agents in the therapy of metastatic brain tumors...
  61. RAPID REGULATION OF THIAZIDE ACTION
    DARRELL FANESTIL; Fiscal Year: 1990
    This application proposes the study of the rapid regulation of the receptor for thiazide-type diuretics. It eminates from our unexpected finding of the unprecedented phenomenon of rapid regulation of this diuretic binding site...
  62. ISOLATION OF THE GENE ENCODING THE NA-K-C1 COTRANSPORTER
    J Gargus; Fiscal Year: 1992
    ..Inhibition of this transport system is the mechanism by which furosemide and other potent diuretics act on renal tubule cells to induce salt and water loss by the kidney...
  63. ENDOGENOUS MODULATION OF OTO- AND NEPHROTOXICITY
    Douglas Hoffman; Fiscal Year: 1992
    ..results in the profound enhancement of the toxicity of the aminoglycoside antibiotics, cisplatin, and loop diuretics, which are limited in their clinical usefulness by their oto- and nephrotoxicity...
  64. Transcriptional regulation and in vivo function of organic anion transporters
    SATISH ERALY; Fiscal Year: 2007
    ..g., beta-lactam antibiotics, NSAIDs, diuretics)...