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Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack TrialBarry R Davis
The University of Texas School of Public Health, Houston, TX 77030, USA
Circulation 113:2201-10. 2006..The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF...
Diuretics: still essential drugs for the management of hypertensionFlavio Danni Fuchs
Servico de Cardiologia, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90 035 903, Porto Alegre, RS, Brazil
Expert Rev Cardiovasc Ther 7:591-8. 2009According to most current international guidelines for hypertension, diuretics are indicated for elderly and black patients, unless they have any of a long list of other preferential indications...- Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failureMichael R Bristow
Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
N Engl J Med 350:2140-50. 2004.... - Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trialHenry R Black
Rush Medical College of Rush University, Chicago, IL 60612, USA
JAMA 289:2073-82. 2003..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial... - Reappraisal of the role of diuretics in heart failureMaya Guglin
University of South Florida, Tampa, USA
Cardiol Rev 17:56-9. 2009The focus of this review is to explore the controversy between the broad acceptance of loop diuretics as a first-line treatment for heart failure (HF) and the data regarding their association to increased morbidity and mortality in HF... - Hydrochlorothiazide versus chlorthalidone in the management of hypertensionKimberly M Neff
New Mexico VA Health Care System, Albuquerque, NM, USA
Cardiol Rev 18:51-6. 2010Thiazide diuretics are a mainstay for the treatment of hypertension... - Thiazide diuretics exacerbate fructose-induced metabolic syndromeSirirat Reungjui
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
J Am Soc Nephrol 18:2724-31. 2007..Thiazide diuretics are frequently used in these patients for treatment of hypertension, but they also exacerbate metabolic syndrome... - The Hong Kong diastolic heart failure study: a randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fractionG W K Yip
Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
Heart 94:573-80. 2008..The effect of renin-angiotensin blockade by irbesartan or ramipril in combination with diuretics on quality of life (QoL), regional and global systolic and diastolic function was assessed in HFNEF patients. - Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigatorsP S Sever
Imperial College School of Medicine, London, UK
J Hypertens 19:1139-47. 2001..To test a second primary hypothesis that a statin compared with placebo will further protect against CHD endpoints in hypertensive subjects with a total cholesterol < or = 6.5 mmol/l... - Treatment of hypertension in patients 80 years of age or olderNigel S Beckett
Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
N Engl J Med 358:1887-98. 2008..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death... - Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazidePatrícia Guerrero
Graduate Study Program in Health Sciences Cardiology, Universidade Federal do Rio Grande do Sul UFRGS, Brazil
Clin Exp Hypertens 30:553-64. 2008..Cough, albeit predominantly mild, was reported more frequently by participants treated with enalapril. We conclude that enalapril is more effective than amiloride to lower BP of patients on hydrochlorothiazide with uncontrolled BP... - Risk factors for thiazide-induced hyponatraemiaK M Chow
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
QJM 96:911-7. 2003..factors for thiazide-induced hyponatraemia, but gender, duration of thiazide use, concomitant therapy with loop diuretics, angiotensin-converting enzyme inhibitors or non-steroidal anti-inflammatory drugs, and renal function were not... - Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)M J Brown
Clinical Pharmacology Unit, University of Cambridge, UK
Lancet 356:366-72. 2000The efficacy of antihypertensive drugs newer than diuretics and beta-blockers has not been established... 
Gout, diuretics and the kidneyE Pascual
Ann Rheum Dis 65:981-2. 2006- Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamidesClaudiu T Supuran
Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
Curr Pharm Des 14:641-8. 2008The widely clinically used benzothiadiazines and high ceiling diuretics, such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide, contain SO(2)NH(2) moieties acting .. - Antihypertensive therapiesRichard E T Smith
Nat Rev Drug Discov 6:597-8. 2007 - Interactions of human organic anion transporters with diureticsHabib Hasannejad
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
J Pharmacol Exp Ther 308:1021-9. 2004The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs... - Very-low-dose combination: a first-line choice for the treatment of hypertension?Bernard Waeber
Division of Clinical Pathophysiology, University Hospital, BH 19, 1011 Lausanne, Switzerland
J Hypertens Suppl 21:S3-10. 2003..This is, for instance, the case for diuretics, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT1) receptor antagonists .. - Current usage of diuretics among hypertensive patients in Japan: the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) studyKayo Murai
Department of Planning for Drug Development, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
Hypertens Res 29:857-63. 2006..Measurement Evaluation (J-HOME) study, we examined the current situation with respect to the prescription of diuretics, including the prevalence of diuretic treatment and the dosages used for patients with essential hypertension in .. - Effects of ULTRAfiltration vs. DIureticS on clinical, biohumoral and haemodynamic variables in patients with deCOmpensated heart failure: the ULTRADISCO studyCristina Giglioli
Department of Heart and Vessels, Viale Morgagni, 85, Florence, Italy
Eur J Heart Fail 13:337-46. 2011To evaluate the clinical, biohumoral, and haemodynamic effects of ultrafiltration vs. intravenous diuretics in patients with decompensated heart failure (HF)... - Continuous haemodynamic monitoring during withdrawal of diuretics in patients with congestive heart failureF Braunschweig
Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
Eur Heart J 23:59-69. 2002..Such data provide useful information for tailoring an optimal diuretic dose in patients with congestive heart failure... - Changes in brain natriuretic peptide levels and bioelectrical impedance measurements after treatment with high-dose furosemide and hypertonic saline solution versus high-dose furosemide alone in refractory congestive heart failure: a double-blind studySalvatore Paterna
Department of Emergency Medicine, University of Palermo, Palermo, Italy
J Am Coll Cardiol 45:1997-2003. 2005..CONCLUSIONS: Our data show that the HSS group reached dry weight more rapidly, a significantly faster reduction in BNP levels, shorter hospitalization stay, and lower incidence in readmissions in the 30-day study period... - Rapid optimization: strategies for optimal care of decompensated congestive heart-failure patients in the emergency departmentW Frank Peacock
Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Rev Cardiovasc Med 3:S41-8. 2002.... - Diuretics in clinical practice. Part II: electrolyte and acid-base disorders complicating diuretic therapyPantelis A Sarafidis
Section of Nephrology and Hypertension, 1st Department of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, St Kiriakidi 1, 54636, Thessaloniki, Greece
Expert Opin Drug Saf 9:259-73. 2010.... - Herbal medicines as diuretics: a review of the scientific evidenceC I Wright
Nutrition, Nutrition and Health Enhancement, Unilever Food and Health Research Institute, Olivier van Noortlaan 120, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
J Ethnopharmacol 114:1-31. 2007..e., hypertension). One class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as well as the amount of sodium in urine... - Calcium channel blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors: effectiveness in combination with diuretics or beta-blockers for treating hypertensionJohn D Bisognano
Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, New York 14642 8679, USA
Vasc Health Risk Manag 3:579-85. 2007..DHPs), angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) added to diuretics or beta-blockers... - Attenuated renal excretion in response to thiazide diuretics in Gitelman's syndrome: a case reportChung-Ho Yeum
Department of Internal Medicine, Cheju National University Medical School, Jeju, Korea
J Korean Med Sci 17:567-70. 2002..The administration of thiazide diuretics may induce a subnormal increase of urinary Na+ and Cl- excretion in patients with Gitelman's syndrome, .. - Pediatric idiopathic intracranial hypertensionLubaina M Rangwala
Neuro ophthalmology Services of the Children s Hospital of Philadelphia, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Surv Ophthalmol 52:597-617. 2007.... - Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox statusD Sankar
Department of Biotechnology, Aarupadai Veedu Institute of Technology, Vinayaka Mission s Research Foundation University, Paiyanoor 603104, Chennai, Tamilnadu, India
Yale J Biol Med 79:19-26. 2006..investigate the effect of sesame oil in hypertensive patients who were on antihypertensive therapy either with diuretics (hydrochlorothiazide) or Beta-blockers (atenolol)... - Metabolic effects of an AT1-receptor blockade combined with HCTZ in cardiac risk patients: a non interventional study in primary carePeter Bramlage
Institute for Clinical Pharmacology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
BMC Cardiovasc Disord 8:30. 2008..For example, diuretics and betablockers worsen glucose metabolism, hence the starting point of the current subanalysis of the CHILI (.. - Antihypertensive efficacy and tolerability of candesartan-hydrochlorothiazide 32/12.5 mg and 32/25 mg in patients not optimally controlled with candesartan monotherapyGerd Bönner
MEDIAN Kliniken, Bad Krozingen, Germany
Blood Press Suppl 2:22-30. 2008..To evaluate the efficacy and tolerability of candesartan cilexetil 32 mg in combination with hydrochlorothiazide (HCT) 12.5 mg or 25 mg in hypertensive patients not optimally controlled with candesartan monotherapy... - Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled study with bumetanideLars Rejnmark
Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
J Bone Miner Res 21:163-70. 2006To study effects of loop diuretics on bone, 87 women were randomized to 1 year of treatment with bumetanide or placebo. Compared with placebo, bumetanide decreased BMD by 2% at the total hip and by 1.4% at the whole body... - Initial experience with fenoldopam after cardiac surgery in neonates with an insufficient response to conventional diureticsJohn M Costello
Division of Cardiac Intensive Care, Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA
Pediatr Crit Care Med 7:28-33. 2006..INTERVENTIONS: Fenoldopam infusion for inadequate urine output despite conventional diuretics. MEASUREMENTS: Demographics, diagnostic information, and surgical procedures were recorded... - Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patientsToshio Ogihara
Osaka University Graduate School of Medicine, Osaka, Japan
Hypertens Res 32:163-7. 2009..Safety and tolerability will also be investigated. A total of more than 4000 patients were recruited and will be followed up for at least 3 years... - Renal effects of treatment with diuretics, octreotide or both, in non-azotemic cirrhotic patients with ascitesGeorgios Kalambokis
Department of Internal Medicine, Medical School of Ioannina, 45110 Ioannina, Greece
Nephrol Dial Transplant 20:1623-9. 2005..with renal dysfunction in cirrhotic patients with ascites, and in turn prevents the use of high doses of diuretics. Furthermore, ample evidence suggests that octreotide can inhibit the activation of the renin-aldosterone axis... - Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failureKamala P Tamirisa
Department of Internal Medicine, Women's L3623-0271, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Am Heart J 148:971-8. 2004..insufficiency had lower baseline body weight and higher baseline serum creatinine, required higher doses of loop diuretics, and were more likely to be treated with thiazide diuretics than controls... - Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD geneKhalid Hussain
London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
J Pediatr 146:706-8. 2005..This mutation resulted in a nearly complete absence of immunoreactive protein and a decrease in fibroblast SCHAD activity... - Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-mediated apoptosisSandeep C Pingle
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
J Biol Chem 279:43157-67. 2004Osmotic diuretics are used successfully to alleviate acute tubular necrosis (ATN) produced by chemotherapeutic agents and aminoglycoside antibiotics... - Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertensionToshihiko Ishimitsu
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
Hypertens Res 32:962-8. 2009..These properties may provide cardiovascular protection in addition to the hypotensive effect... - Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)Mahboob Rahman
Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
Arch Intern Med 165:936-46. 2005..Participants assigned to receive amlodipine had a higher GFR than those assigned to receive chlorthalidone, but rates of development of ESRD were not different between the groups... - Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive AgentsM R Lakshman
Lipid Research Laboratory, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
Arch Intern Med 159:551-8. 1999..Concern based on the reported short-term adverse effects of antihypertensive agents on plasma lipid and lipoprotein profiles (PLPPs) has complicated the therapy for hypertension... - Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significanceMarco Metra
Section on Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia, Italy
Eur J Heart Fail 10:188-95. 2008..Renal function is a powerful prognostic variable in patients with heart failure (HF). Hospitalisations for acute HF (AHF) may be associated with further worsening of renal function (WRF)... - Potassium-sparing diureticsJ D Horisberger
Yale University School of Medicine, Department of Physiology, New Haven, Conn
Ren Physiol 10:198-220. 1987Amiloride, triamterene, and the spirolactones are potassium-sparing diuretics which act on the distal parts of the nephron, from the late distal tubule to the collecting duct... - Adverse prognostic significance of new diabetes in treated hypertensive subjectsPaolo Verdecchia
Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
Hypertension 43:963-9. 2004..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes... - A propensity-matched study of the effects of chronic diuretic therapy on mortality and hospitalization in older adults with heart failureAli Ahmed
University of Alabama at Birmingham, and Veterans Affairs Medical Center, Birmingham, 1530 3rd Avenue South, CH19 219, Birmingham, Alabama 35294 2041, USA
Int J Cardiol 125:246-53. 2008Non-potassium-sparing diuretics may increase mortality and hospitalizations in heart failure patients... - [IQWIG Preliminary Report: Diuretics are the best antihypertensives. How does it go on with the high blood pressure therapy? (interview)]Peter Sawicki
MMW Fortschr Med 149:6-8. 2007 - Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazideSteven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, 5850 W Wilshire Boulevard, Oklahoma City, OK 73132, USA
Am J Hypertens 17:252-9. 2004..The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ)... - Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusionNatarajan Aravindan
Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University, Durham, North Carolina, USA
Ren Fail 28:25-35. 2006Loop diuretics are known to affect renal hemodynamics and possibly gene transcription, but the specific effect of furosemide on renal angiogenesis gene expression after acute ischemia is not known... - Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ fluxVijay Lyall
Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
J Gen Physiol 125:569-85. 2005..We conclude that in the presence of mineral salts, ethanol modulates the Bz-insensitive VR-1 variant salt taste receptor... - Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BBjorn Dahlof
Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
Lancet 366:895-906. 2005..of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used... - Effects of initial antihypertensive drug class on patient persistence and compliance in a usual-care setting in the United StatesBimal V Patel
MedImpact Healthcare Systems, Inc, San Diego, CA 92131, USA
J Clin Hypertens (Greenwich) 9:692-700. 2007..angiotensin-converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), beta-blockers (BBs), or diuretics were followed for 1 year (N=242,882). A higher proportion of ARB patients (51... - Loop diuretics for patients with acute renal failure: helpful or harmful?Norbert Lameire
JAMA 288:2599-601. 2002 - Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trialStevo Julius
University of Michigan, Ann Arbor, USA
Lancet 363:2022-31. 2004.... - Cyclooxygenase inhibition causes marked impairment of renal function in elderly subjects treated with diuretics and ACE-inhibitorsTord Juhlin
Department of Cardiology, , Malm, Sweden
Eur J Heart Fail 7:1049-56. 2005..This impairment is observed both with and without activation of the renin-angiotensin system and ACE-inhibitor treatment but is more pronounced after pre-treatment... - Diuretics in the LIFE studyJohji Kato
Lancet 364:413; author reply 413-4. 2004 - Diuretics and mortality in acute renal failureShigehiko Uchino
Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
Crit Care Med 32:1669-77. 2004OBJECTIVE: According to recent research, diuretics may increase mortality in acute renal failure patients. The administration of diuretics in such patients has been discouraged... - Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responsesVijay Lyall
Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
J Gen Physiol 125:587-600. 2005..VR-1 KO mice demonstrated no Bz-insensitive CT response to NaCl and no sensitivity to ethanol. We conclude that ethanol increases salt taste sensitivity by its direct action on the Bz-insensitive VR-1 variant salt taste receptor... - Persistence with treatment in newly treated middle-aged patients with essential hypertensionSylvie Perreault
Faculty of Pharmacy, University of Montreal, Quebec, Canada
Ann Pharmacother 39:1401-8. 2005..Surveys have shown that hypertension has been diagnosed in many patients but remains uncontrolled. One factor may be the lack of persistence to treatment... - Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/beta-blocker-based treatment regimen: a subanalysis of the Captopril Prevention ProjectL Niskanen
Department of Medicine, University of Kuopio, Kuopio, Finland
Diabetes Care 24:2091-6. 2001..One planned subanalysis of the CAPPP was to evaluate the outcome in the diabetic patient group... - Combination of hydrochlorothiazide or benazepril with valsartan in hypertensive patients unresponsive to valsartan aloneB Waeber
Division of Clinical Pathophysiology and Medical Teaching, University Hospital, Lausanne, Switzerland
J Hypertens 19:2097-104. 2001.... - Calcium channel blocker nifedipine slows down progression of coronary calcification in hypertensive patients compared with diureticsM Motro
Cardiac Rehabilitation Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
Hypertension 37:1410-3. 2001..Using this method, our objective was to determine whether administration of nifedipine once daily in lieu of diuretics in high-risk hypertensive patients will arrest or slow down the progression of coronary artery calcification... - Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trialP Gentilini
Institute of Internal Medicine, University of Florence School of Medicine, Italy
J Hepatol 30:639-45. 1999..We investigated whether intravascular volume expansion with albumin exert beneficial effects in cirrhosis with ascites... - Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertensionS Oparil
University of Alabama at Birmingham, Community Health Sciences, USA
Am J Cardiol 87:721-6. 2001..In conclusion, losartan/ HCTZ, alone or as part of a regimen with other standard antihypertensive agents, is effective and well tolerated in the treatment of patients with severe hypertension... - Effects of different ACE inhibitor combinations on albuminuria: results of the GUARD studyG L Bakris
Hypertensive Diseases Unit, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Kidney Int 73:1303-9. 2008..The dissociation between reductions in blood pressure and albuminuria may be related to factors other than blood pressure... - [Risk factors to be considered at the beginning of antihypertensive therapy in diabetes mellitus]Gyorgy Jermendy
Bajcsy Zsilinszky Kórház III Belgyógyászati Osztály, Budapest
Orv Hetil 145:949-56. 2004..It is reasonable to initiate antihypertensive therapy primarily with a low dose combination of two agents in diabetic patients with hypertension... - Combination therapy as first-line treatment for hypertensionIrene Gavras
Hypertension and Atherosclerosis Section, Boston University School of Medicine, 715 Albany Street, W508, Boston, MA 02118, USA
Curr Hypertens Rep 6:267-72. 2004.... - Mechanisms and management of hypertensive heart disease: from left ventricular hypertrophy to heart failureJoseph L Izzo
State University of New York at Buffalo, Buffalo, NY 14215, USA
Med Clin North Am 88:1257-71. 2004.... - [Antihypertensive therapy in 357 inpatients of elderly isolated systolic hypertension]Li hua Zhai
Department of Geriatrics, Shenzhen People s Hospital, Second Affiliated Hospital of Medical College, Jinan University, Shenzhen 518020, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:719-22, 725. 2005..To determine the therapeutic status and rate of reaching target blood pressure in elderly isolated systolic hypertension (EISH) patients who were hospitalized and to discuss the rationality of the drug therapy... - [Medical treatment of hypertension--what treatment for what patients?]W Zidek
Medizinischen Klinik IV Charité, Universitatsmedizin Berlin
MMW Fortschr Med 146:31-4. 2004..Resistance to therapy should prompt consideration of a number of causes, in particular noncompliance on the part of the patient... - [Hypertension in patients with heart failure]Noboru Takekoshi
Department of Cardiology, Kanazawa Medical University
Nippon Rinsho 62:478-83. 2004 - [Control of blood pressure in prevention of hypertensive end-organ damage]Makiko Kido
Department of Nephrology and Endocrinology, University of Tokyo School of Medicine
Nippon Rinsho 62:389-93. 2004 - [Exercise in arterial hypertension]Hans-Georg Predel
,
Herz 31:525-30. 2006.... - Treatment of isolated systolic hypertensionGordon S Stokes
Curr Hypertens Rep 8:377-83. 2006..Treatment of ISH with diuretics, calcium channel blockers (CCBs), and angiotensin II inhibitors is effective in reducing systolic blood pressure,.. - The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effectsH Knauf
Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
Eur J Clin Pharmacol 62:885-92. 2006Thiazide diuretics are known to induce a transient fall of the glomerular filtration rate (GFR), which, in turn, reduces tubular Na(+) load. This tubuloglomerular feedback (TGF) curtails the natriuretic effect of this class of diuretics... - Long-term safety of antihypertensive therapyEhud Grossman
Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
Prog Cardiovasc Dis 49:16-25. 2006..Despite the concern that has been raised regarding the long-term safety of some antihypertensive agents, it is clear that lowering BP is safe and beneficial... - The ASCOT trial: a closer lookNorman M Kaplan
J Hypertens 24:211-4. 2006 - Modern antihypertensive therapy: a report from the 22nd annual meeting of the American Society of HypertensionX Rabasseda
Prous Science Medical Information Department
Timely Top Med Cardiovasc Dis 11:E17. 2007 - [Therapeutical strategies in hypertensive patients presenting heart failure symptoms]Christian Ebner
II Interne Abteilung mit Kardiologie und Angiologie und Intensivstation, A ö Krankenhaus der Elisabethinen Linz, Linz, Osterreich
Wien Med Wochenschr 154:8-14. 2004..In progressive heart failure the use of diuretics is necessary and effective especially when fluid overload exists... - Antihypertensive drugs and arterial stiffnessAzra Mahmud
Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland
Expert Rev Cardiovasc Ther 1:65-78. 2003..There are clear differences in the effects of antihypertensive drugs on these parameters and stiffness is becoming a therapeutic target in its own right... - [Drug treatment of hypertension in hemodialysed patients]T Hannedouche
Service de Nephrologie, Hopitaux Universitaires de Strasbourg, 67091 Strasbourg Cedex, France
Nephrol Ther 3:S185-90. 2007..On a practical ground, prescription will be driven by pharmacokinetics considerations and mostly according to specific indications pertinent to cardiovascular complications associated with hypertension... - [Kidney and hypertension--evidence based medicine]Naoyuki Nakao
Nippon Naika Gakkai Zasshi 93:1639-45. 2004 - Management of hypertension in patients with CKD: differences between primary and tertiary care settingsRoberto Minutolo
Department of Nephrology, Second University of Naples, Naples, Italy
Am J Kidney Dis 46:18-25. 2005..We compared hypertension management in patients with CKD followed up in PC and nephrology tertiary care (TC)... - Rate and determinants of 10-year persistence with antihypertensive drugsBoris Lg Van Wijk
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, The Netherlands
J Hypertens 23:2101-7. 2005..52-2.84; 40-59 years: (reference), > or = 60 years: OR 0.69; 95% CI 0.54-0.89]. More patients who started with diuretics (reference) and beta blockers (OR 1.15; 95% CI 0.87-1... - [Antihypertensive effectiveness and tolerance of cicletanine. Results obtained with bitherapy]T Tarrade
IPSEN, Paris
Arch Mal Coeur Vaiss 82:103-8. 1989..Altogether, cicletanine proved to be effective and well tolerated when administered in combination with other antihypertensive drugs belonging to three main therapeutic classes... - [Intervention studies on elderly hypertensive patients in Japan]Fumio Saito
Department of Cardiology, Surugadai Nihon University Hospital
Nippon Rinsho 63:1078-85. 2005..in elderly hypertensive patients has been shown by the clinical intervention studies in western countries, using diuretics, beta-blockers, Ca antagonist, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers... - [Management of elderly hypertensive individuals with hyperlipidemia]Koichi Kozaki
Department of Geriatric Medicine, Kyorin University School of Medicine
Nippon Rinsho 63:1061-6. 2005..system inhibitors and calcium channel blockers would be the first choices, and the combination therapy with diuretics or alpha-blockers would be the next choice... - [Heart failure in hypertension in the elderly]Shinji Seto
Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University
Nippon Rinsho 63:1041-6. 2005..control by angiotensin-converting enzyme inhibitors and angiotensin-II receptor antagonists along with low-doses diuretics as first-line therapy is recommended... - [Old or new antihypertensives--which are better?]J Schrader
St Josefs Hospital, Cloppenburg
MMW Fortschr Med 147:36-7, 39-40. 2005..calcium antagonists, ACE-inhibitors and angiotensin 1 receptor blockers) together with the classical agents (diuretics and beta blockers) are recognized as equally justifiable as the five agents of first choice in the treatment of .. - Serum concentration of potassium in chronic heart failure patients administered spironolactone plus furosemide and either enalapril maleate, losartan potassium or candesartan cilexetilM Saito
Department of Pharmacy, National Hospital Organization Osaka Medical Center, Japan
J Clin Pharm Ther 30:603-10. 2005.... - [The treatment of arterial hypertension: new trials--new approaches]Iu A Karpov
Cardiology Research Complex, 121552 Moscow, Russia
Kardiologiia 43:87-90. 2003 - Comparison of the combination of enalapril and a very low dose of hydrochlorothiazide with atenolol in patients with mild-to-moderate hypertension. Scandinavian Study GroupI Os
Department of Medicine, Ullevaal University Hospital, Oslo, Norway
Am J Hypertens 10:899-904. 1997..019); there was a trend toward more patients achieving target diastolic BP (<90 mm Hg, P = .053). No clinically important differences in safety and tolerability were observed... - Hypertension-related morbidity and mortality in African Americans--why we need to do betterKeith C Ferdinand
Heartbeats Life Center, Xavier University College of Pharmacy, New Orleans, LA, USA
J Clin Hypertens (Greenwich) 8:21-30. 2006..When given as monotherapy, diuretics and calcium channel blockers may be relatively more effective in lowering blood pressure in African Americans .. - [Hypertension therapy in practice test. Calcium antagonist receives good marks]M Keck
Fachklinik fur Herz- und Kreislaufkrankheiten Drei-Burgen-Klinik, , Ebernburg
MMW Fortschr Med 147:51. 2005 - The role of combination therapy in the treatment of hypertensionM Moser
Yale University School of Medicine, New Haven, Connecticut, USA
Am J Hypertens 11:73S-78S; discussion 95S-100S. 1998..Many different combinations of diuretics and beta-blockers, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists, as .. - Association between cardiovascular outcomes and antihypertensive drug treatment in older womenSylvia Wassertheil-Smoller
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
JAMA 292:2849-59. 2004..However, many patients with hypertension require treatment with more than 1 drug class to achieve blood pressure control. The relative benefits or risks of 2-drug-class combinations are not well known... - Drug treatment of essential hypertension: the case for initial combination therapyL Welsh
Department of Clinical Pharmacology, GKT School of Medicine (Cardiovascular Division, King's College London, Guy's Hospital Campus, London, UK
Int J Clin Pract 58:956-63. 2004.... - The importance of blood pressure controlSarah C Jarvis
Richford Gate Medical Practice, Richford Street, London, UK
Prof Nurse 20:48. 2004 - Cardiovascular outcomes and antihypertensive drug treatment in older womenMichael Bursztyn
JAMA 293:1588; author reply 1588-9. 2005 - Novel combinations in the treatment of hypertensionD A Sica
Division of Nephrology, Virginia Commonwealth University Health System, Richmond, VA, USA
Minerva Urol Nefrol 57:129-39. 2005..Such drug combinations include within class switching of diuretics, combining a thiazide-type diuretic with a calcium-channel blocker, utilizing 2 calcium-channel blockers from .. - [Recent intervention studies with antihypertensive drugs and their influence on guidelines]Karl Heinz Rahn
Medizinische Klinik und Poliklinik D, Universitatsklinikum, Muenster
Med Klin (Munich) 98:771-5. 2003..b>Diuretics, beta-blockers, calcium antagonists, angiotensin-converting enyzme (ACE) inhibitors, and angiotensin I (AT(1)) .. - Hypertension: just the factsKathy Sharp
Blue Ridge Medical Specialists, Bristol, TN, USA
Clin J Oncol Nurs 10:727-9. 2006
Research Grants
- CELLULAR CALCIUM TRANSPORT IN URINARY EPITHELIAPeter Friedman; Fiscal Year: 2003..We will: 1) Test the hypothesis that thiazide diuretics can inhibit Na+/Ca2+ exchange; and 2) Characterize the stimulatory effects of PTH on Na+/Ca2+ exchange...
- Hypertension PharmacogeneticsJulie Johnson; Fiscal Year: 2006..of verapamil, and will significantly further our understanding of the pharmacogenetics of p-blockers, thiazide diuretics, and ACE inhibitors...
- RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSDouglas Kiel; Fiscal Year: 1993..for this change in BMD will include weight, physical activity (leisure), caffeine, smoking, alcohol, thiazide diuretics, testosterone levels, dietary calcium, 25 hydroxy-vitamin D levels and thyroid hormone replacement and hormone ..
- Pharmacogenetics and Cardiovascular EventsBruce Psaty; Fiscal Year: 2006..cardiovascular drugs: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, all classes of diuretics, alpha blockers, beta-blockers, central alpha agonists, calcium antagonists, and estrogens...
- REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSIONPeter Igarashi; Fiscal Year: 1999..the thick ascending limb of the loop of Henle and represents the site of action of the clinically important loop diuretics furosemide and bumetanide. Importantly, expression of Nkcc2 transcripts is only observed in the kidney...
- A Family Partnership Intervention for Heart FailureSandra Dunbar; Fiscal Year: 2009..urinary sodium), medication adherence to HF drugs including angiotensin converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ..
- REGULATION OF KAPPA OPIOID RECEPTORSLee Yuan Liu Chen; Fiscal Year: 2002..Kappa agonists may be useful as analgesics, water diuretics and antipruritic agents...
- Cellular Pharmacology of Kappa Opioid ReceptorLee Yuan Liu Chen; Fiscal Year: 2007..effects, including analgesia, dysphoria and water diuresis and kappa agonists may be useful as analgesics, water diuretics and antipruritic drugs...
- Combined Computational and Wet Lab Screening for Drugs Tested via OATsSanjay K Nigam; Fiscal Year: 2010..kidney, liver) of many common drugs (eg. antibiotics, antivirals, chemotherapeutics, NSAIDs, antihypertensives, diuretics)...
- CHARACTERIZATION OF INTESTINAL ABSORPTION OF VITAMIN B1HAMID SAID; Fiscal Year: 2003..renal disease patients, the elderly, in inborn errors of thiamine metabolism, and in long-term users of diuretics. Humans and other mammals can not synthesize thiamine, and thus, must obtain the vitamin from exogenous sources ..
- Uric Acid and Hypertension in African-AmericansRichard Johnson; Fiscal Year: 2007Thiazide diuretics are associated with many metabolic side effects including hyperuricemia, gout, insulin resistance, and hyperlipidemia. These very conditions are already highly prevalent in African-Americans...
- Treatment of Calcium Nephrolithiasis Sodium ThiosulfateJohn Asplin; Fiscal Year: 2006..for calcium nephrolithiasis that have been proven effective in prospective placebo controlled trials, thiazide diuretics, potassium citrate salts, and allopurinol...