Genomes and Genes
central muscle relaxants
Summary: A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Publications172 found, 100 shown here
- Cooling methods used in the treatment of exertional heat illnessJ E Smith
Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
Br J Sports Med 39:503-7; discussion 507. 2005..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
- GMFM 1 year after continuous intrathecal baclofen infusionLinda E Krach
Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
Pediatr Rehabil 8:207-13. 2005..05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved...
- Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in childrenA Leland Albright
Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurosurg 101:64-8. 2004....
- Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofenJørgen Feldbaek Nielsen
Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
Clin Neurol Neurosurg 104:142-5. 2002..Complications are often due to infection or catheter problems...
- Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertoniaA S Burns
Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Spinal Cord 39:413-9. 2001..CONCLUSIONS: Intrathecal baclofen is a safe and effective intervention for treating upper extremity hypertonia of spinal origin. In addition, the level of intrathecal catheter placement is felt to be of importance...
- Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscleTakamitsu Hosoya
Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
Bioorg Med Chem 11:663-73. 2003....
- Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibersP Szentesi
Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, H-4012
J Gen Physiol 118:355-75. 2001..The channel displayed a constant open probability for as long as 30-50 min after the application of the drug. These data locate the binding site for dantrolene to be on the SR membrane, but be distinct from the purified RYR itself...
- [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscleTakamitsu Hosoya
Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan
Bioorg Med Chem Lett 12:3263-5. 2002....
- Malignant hyperthermiaM Denborough
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
Lancet 352:1131-6. 1998..By far the most common is inherited as a mendelian dominant characteristic and at present mutations in the human RYR account for no more than 20% of susceptible families...
- Myofascial pain disorders: theory to therapyAnthony H Wheeler
Pain and Orthopedic Neurology, Charlotte Spine Center, Charlotte, North Carolina 28207, USA
Drugs 64:45-62. 2004..Chronic myofascial pain is usually a product of both physical and psychosocial influences that complicate convalescence...
- Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibresT Ikemoto
Department of Pharmacology, Saitama Medical School, Moroyama machi, Saitama 350 0495, Japan
Br J Pharmacol 134:729-36. 2001..8. These results indicate that the difference in opening modes of the RyR-Ca(2+) release channel is recognized by certain Dan derivatives...
- Managing an effective treatment for neuroleptic malignant syndromeUdo Reulbach
Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Crit Care 11:R4. 2007..The aim of this study was to prove the efficacy of different NMS treatment strategies, focusing on the efficacy of dantrolene...
- Effects of dantrolene on rat diaphragm muscle during postnatal maturationG Orliaguet
Department of Anesthesiology, Centre Hospitalo-Universitaire Necker-Enfants Malades, Paris, France
Anesthesiology 94:468-74. 2001..Our study suggests that developmental changes in the pharmacologic response to dantrolene are more rapid than those of ryanodine...
- Placement of baclofen pumps through the foramen magnum and upper cervical spineKristine Dziurzynski
Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Childs Nerv Syst 22:270-3. 2006..As an alternative to placing the pump catheter through the lumbar spine, we report our experience with placement of the catheter in the spinal canal via a cervical approach through the foramen magnum...
- Opisthotonus and intrathecal treatment with baclofen (ITB) in childrenBerten Ceulemans
Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
Eur J Pediatr 167:641-5. 2008..This increase in weight might be due to a reduction in energy expenditure as a result of the decrease in spasticity. Intrathecal treatment with baclofen should be considered in every child with opisthotonus...
- Dosage of intrathecal baclofen maintenance therapy in the spastic syndromesYoussef Fares
Neurosurgical Service, Ntra Sra Clinic of the Conception Jimenez Diaz Foundation, Madrid, Spain
J Med Liban 52:13-8. 2004..81 microg/day in the final phase. These doses were higher in patients with medullary traumatic lesion, diffuse cerebral lesion and spastic idiopathic paraparesis. Relatively mild side effects were produced by the therapeutic doses used...
- Epilepsy and intrathecal baclofen therapy in children with cerebral palsyVincenzo Buonaguro
Department of Paediatric Orthopedics, Children s Hospital V Buzzi, Milan, Italy
Pediatr Neurol 33:110-3. 2005..We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity...
- Intrathecal baclofen for the treatment of spasticityI Dones
Department of Neurosurgery, Instituto Nazionale Neurologico C Besta, Via Celoria, Milano, Italy
Acta Neurochir Suppl 97:185-8. 2007..Currently, treatment of spasticity with ITB is the most effective way of reducing spasticity regardless of its cause...
- Functional effects of spinal baclofenHermann Muller
Dpt Anesthesiology, Intensive Care and Pain Therapy, Kemperhof Hospital, Koblenz, Germany
Przegl Lek 64:1-2. 2007
- Surgical management of spasticity of cerebral origin in childrenS Sgouros
Department of Neurosurgery, Birmingham Children s Hospital, Birmingham, UK
Acta Neurochir Suppl 97:193-203. 2007..Current pumps have practical limitations but, in the next decade, it is anticipated that technological improvements will render the pumps more patient friendly...
- Infusion of intrathecal baclofen for acute withdrawal. Technical noteBradley S Duhon
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
J Neurosurg 107:878-80. 2007..In both cases, the patients recovered to their neurological baseline level, and lasting consequences of serious withdrawal were avoided...
- Quality of life of patients with telemetric pumps for intrathecal baclofen infusion: data and limitations of assessment scalesPlacido Bramanti
Centro Studi Neurolesi, University of Messina, Italy
Funct Neurol 19:227-31. 2004..These results encourage us to continue this study in a larger patient sample, considering different types of pathology and presence/absence of caregivers...
- [Intrathecal baclofen in severe spasticity due to multiple sclerosis]Jarosław Sławek
Kliniki Neurochirurgii Akademii Medycznej w Gdańsku
Neurol Neurochir Pol 37:1135-42; discussion 1143. 2003..At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted...
- Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 casesK D Ethans
Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Spinal Cord 43:214-8. 2005..The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail...
- Salvage of baclofen pump pocket infection with muscle flapBishara S Atiyeh
Plast Reconstr Surg 114:1661-3. 2004
- Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal originA Zahavi
Department of Rehabilitation, University Groningen, Netherlands
J Neurol Neurosurg Psychiatry 75:1553-7. 2004..To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen...
- Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain reliefShearwood McClelland
Department of Neurosurgery, University of Minnesota Medical School, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Muscle Nerve 37:396-8. 2008..Postoperative pain reduction was predicted by the degree of pain reduction following preoperative ITB test injection. These results support ITB as a treatment modality for pain associated with spasticity in ALS...
- Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump functionMartin O'Connell
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Nucl Med 29:578-80. 2004
- Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patientsR Plassat
Department of Physical Medicine and Rehabilitation, CHU Angers, France
Spinal Cord 42:686-93. 2004..Case series of a consecutive sample. Retrospective audit...
- Intrathecal baclofen in the management of spasticity due to cerebral palsyMichael Vloeberghs
Queens Medical Centre, Nottingham, UK
Pediatr Rehabil 8:172-9. 2005..However, further research is required to set criteria for treatment. This paper offers insight into the national act on baclofen and the experience at the Nottingham University Hospital...
- Intrathecal baclofen in the treatment of adult spasticityJoseph C Hsieh
Section of Neurosurgery, University of Chicago, Illinois 60637, USA
Neurosurg Focus 21:e5. 2006..In this paper the authors survey the use of oral and intrathecal baclofen therapy, detail the surgical process, and explain the risks and benefits of the procedure...
- Continuous intrathecal baclofen administration by a fully implantable electronic pump for severe spasticity treatment: our experienceA Guglielmino
Anesthesia and Intensive Care Unit, Polyclinic University Hospital of Catania, Catania, Italy
Minerva Anestesiol 72:807-20. 2006....
- [Coma induced by an overdose of intrathecal baclofen]H Alonso-Navarro
Rev Neurol 43:63-4. 2006
- Intrathecal baclofen for muscle spasticity and pain--two case reportsDhafir Al Khudhairi
Sultan Bin Abdelaziz Humanitarian Centre and Riyadh Armed Forces Hospital, Saudi Arabia
Middle East J Anesthesiol 18:971-6. 2006
- [Management of increase in spasticity in patients with intrathecal baclofen pumps]N Roche
Service de médecine physique et réadaptation, Hopital Raymond Poincare, APHP, Universite de Versailles Saint Quentin, 104, Boulevard Raymond Poincare, 92380 Garches, France
Ann Readapt Med Phys 50:93-9. 2007..Diagnosis of these complications can be difficult. A diagnostic tree would be a useful tool in cases of suspected malfunctioning of the intrathecal bacolfen infusion system and would standardise the diagnostic procedure...
- Intrathecal baclofen therapy: ten steps toward best practiceBarbara Ridley
Alta Bates Summit Medical Center, Berkeley, CA, USA
J Neurosci Nurs 38:72-82. 2006....
- Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticityDobrivoje S Stokic
Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA
Clin Neurophysiol 117:1283-9. 2006..To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia...
- Best-practice surgical techniques for intrathecal baclofen therapyA Leland Albright
Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
J Neurosurg 104:233-9. 2006..Panel members advocate the aforementioned techniques to improve the efficacy of and decrease the morbidity associated with ITB therapy...
- Interaction of ventriculoperitoneal shunt and baclofen pumpDaniel H Fulkerson
Pediatric Neurosurgery Service, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 1134, Indianapolis, IN 46202, USA
Childs Nerv Syst 23:733-8. 2007..The authors present three cases of children with shunted hydrocephalus and intrathecal delivery of baclofen via an implanted pump. Each case illustrates a potential interaction of these devices...
- Long-term intrathecal baclofen therapy in ambulatory patients with spasticitySaud A Sadiq
MS Research and Treatment Center of New York, Albert Einstein College of Medicine, 425 West 59th Street, Suite 7C, New York, NY 10019, USA
J Neurol 253:563-9. 2006..This retrospective study is designed to determine the long-term ambulatory function in patients receiving ITB...
- Inflammatory mass of an intrathecal catheter in patients receiving baclofen as a sole agent: a report of two cases and a review of the identification and treatment of the complicationTimothy R Deer
The Center for Pain Relief, Charleston, West Virginia and Department of Anesthesiologoy, West Virginia University, Charleston, West Virginia 25301, USA
Pain Med 8:259-62. 2007..Intrathecal baclofen has been used to treat spasticity secondary to stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and other neurological disease...
- The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive casesFrancesco Motta
Department of Paediatric Orthopaedics, V Buzzi Children s Hospital, Milan, Italy
J Neurosurg 107:32-5. 2007..The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants...
- Pharmacologic interventions for reducing spasticity in cerebral palsyDilip R Patel
Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
Indian J Pediatr 72:869-72. 2005....
- A clinical study of intrathecal baclofen using a programmable pump for intractable spasticityDaniel Guillaume
Centre Neurologique et de Réadaptation Fonctionnelle, Fraiture en Condroz, Belgium
Arch Phys Med Rehabil 86:2165-71. 2005..To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity...
- Intrathecal baclofen therapy in patients with severe spasticityG A Marra
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
Acta Neurochir Suppl 97:173-80. 2007..These treatments, do not resolve spasticity in about 33% of cases. In these severe cases, more invasive procedures such as muscle infiltrations with botulin toxin and intrathecal baclofen infusion can be used...
- Intrathecal antispastic drug application with implantable pumps: results of a 10 year follow-up studyA Koulousakis
Department of Neurosurgery, Cologne University, Cologne, Germany
Acta Neurochir Suppl 97:181-4. 2007..Destructive procedures such as myelotomy are no longer performed in our department in order to treat spasticity...
- Intrathecal baclofen therapy in childrenA Leland Albright
Department of Neurosurgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
Neurosurg Focus 21:e3. 2006..Additional investigation is needed to determine the effects of ITB on other movement disorders such as athetosis and chorea...
- Baclofen toxicity in an 8-year-old with an intrathecal baclofen pumpRonald N Yeh
Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Emerg Med 26:163-7. 2004..This report describes the clinical presentation, unfamiliar dilemmas, and the management of a pediatric patient with intrathecal baclofen toxicity, noting problems that may arise in the care of these patients...
- [Treatment of severe spacticity in multiple sclerosis by continuous intrathecal baclofen]Predrag Peric
Vojnomedicinska akademija, Klinika za neurohirurgiju, Beograd, Srbija i Crna Gora
Vojnosanit Pregl 63:187-91. 2006..Continuous intrathecal administration of baclofen (ITB), using a subcutaneously implanted programmable infusion pump, is a minimally invasive, reversible method for the treatment of severe diffuse spasticity of the spinal origin...
- Intrathecal baclofen for the treatment of spasticity of cerebral originJennifer Disabato
Department of Child Neurology, Children s Hospital, Denver, CO, USA
J Spec Pediatr Nurs 8:31-4. 2003..Close collaboration and communication regarding the child and his/her response to ITB is essential to providing safe and effective care for this challenging population of patients...
- Intrathecal baclofen therapy in children with cerebral palsyTed R Brown
Arch Phys Med Rehabil 84:624; author reply 624. 2003
- Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: a descriptive pilot studyKristie F Bjornson
Children s Hospital and Regional Medical Center, Neurodevelopmental Clinic, Spasticity Management Clinic, Seattle, WA, USA
Arch Phys Med Rehabil 84:500-6. 2003..To describe the oral motor, communication, and nutritional status of children receiving intrathecal baclofen (ITB) therapy for spasticity of cerebral origin...
- Combined treatment with BTX-A and ITB for spasticity: case reportChandler E Gill
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
Tenn Med 100:41-2, 44. 2007..Expanded investigations should be carried out to evaluate the efficacy of combined therapy in patients with mental retardation...
- A review of the complications of intrathecal baclofen in patients with cerebral palsyKat Kolaski
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
NeuroRehabilitation 22:383-95. 2007..However, until we have consistent, reliable reports of complications, it will not be possible to perform specific risk/benefit analyses. Recommendations for improving investigation in this important area are discussed...
- Intrathecal baclofen withdrawal: a case report and review of the literatureTord D Alden
Department of Neurosurgery, St Louis Children s Hospital, One Children s Place, Suite 4S20, Washington University School of Medicine, MO 63110, USA
Childs Nerv Syst 18:522-5. 2002..Withdrawal from oral baclofen has been well described. Intrathecal baclofen withdrawal has been less frequently reported. We present a case of withdrawal after intrathecal baclofen pump catheter failure...
- Intrathecal baclofen therapy in adults and guideline for clinical nursing careRozina Bhimani
Sister Kenny Rehabilitation Associates, Abbott Northwestern Hospital, Minneapolis, MN, USA
Rehabil Nurs 33:110-6. 2008..A fundamental understanding of the intrathecal baclofen pump allows nurses to provide cutting-edge technological and individualized care with compassion...
- Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticityMarcus Pohl
Dept of Neurological Rehabilitation, Klinik Bavaria, An der Wolfsschlucht 1 2, 01731 Kreischa, Germany
J Neurol 250:1195-200. 2003..5 hours, with a maximal effect at 4 hours after intrathecal baclofen injection. Clinical scales used to determine the effect of BBT should thus be carried out during this period-ideally at 4 hours after baclofen injection...
- Subfascial implantation of intrathecal baclofen pumps in children: technical noteB H Kopell
Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
Neurosurgery 49:753-6; discussion 756-7. 2001..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
- Intrathecal baclofen for spasticity caused by thrombotic strokeB L Gwartz
Pain Diagnosis and Treatment, Inc, Glendora, CA 91741-4205, USA
Am J Phys Med Rehabil 80:383-7. 2001..The patient achieved substantial functional gains as well as improved ease of care, quality of life, and cessation of narcotic use...
- Cyproheptadine for intrathecal baclofen withdrawalJay M Meythaler
Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
Arch Phys Med Rehabil 84:638-42. 2003..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
- Intrathecal baclofen withdrawal mimicking sepsisLouise W Kao
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Emerg Med 24:423-7. 2003..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
- [Intrathecal baclofen for treatment of spasticity in patient with cerebral palsy--a preliminary report]Marek Jozwiak
Klinika Ortopedii Dzieciecej, Akademia Medyczna im Karola Marcinkowskiego w Poznaniu
Chir Narzadow Ruchu Ortop Pol 68:253-9. 2003..Early results of spasticity treatment in cerebral palsy with intrathecal baclofen infusions are very promising...
- [Baclofen dose in a screening test and in a baclofen pump filling--is there any differences]Przemysław Grzegorzewski
Oddział Neurochirurgii, Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:8-12. 2007..In this study we compared a bolus intrathecal injection given in a screening test with doses uses for filling a baclofen pump. In selected group we observed increased Baclofen dose due to dose given in screening test...
- Implantable baclofen pump as an adjuvant in treatment of pressure soresSarah A Mess
Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA
Ann Plast Surg 51:465-7. 2003..Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients...
- Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literatureB M Soni
Regional Spinal Injuries Centre, Southport and Ormskirk NHS Trust, Southport, UK
Spinal Cord 41:586-9. 2003..Case report...
- Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary studyGerard E Francisco
Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas Houston Medical School, Houston, TX, USA
Arch Phys Med Rehabil 84:1194-9. 2003..To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors...
- [Assessment of spasticity therapy with baclofen pump in children]Anna Swierczyńska
Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:15-7. 2007..The aim of this study was to assess of treatment of spasticity in children with baclofen pump, before and after pump implantation...
- Monitoring of creatinine kinase during weaning of intrathecal baclofen and with symptoms of early withdrawalSam C Colachis
Department of Physical Medicine and Rehabilitation and SCI Rehabilitation, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Am J Phys Med Rehabil 82:489-92. 2003....
- [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]Alicja Fafara
Oddział Neurochirurgii Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:18-21. 2007..It results also in improvement of patients and their families quality of life. The aim of study was to assess the effects after baclofen pump implantation due to parents expectations...
- Intrathecal baclofen for spasticity management in Rett syndromeVivek Kadyan
Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA
Am J Phys Med Rehabil 82:560-2. 2003..The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome...
- On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966B A McMillen
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC
J Neural Transm Gen Sect 89:11-25. 1992..Thus, the effects of these muscle relaxants on DA neurons are mediated by a mechanism other than strychnine-insensitive glycine or GABAb receptors...
- [Centrally acting muscle relaxants and traffic hazards]J G Bramness
Statens rettstoksikologiske institutt, Oslo
Tidsskr Nor Laegeforen 120:1966-9. 2000..In later years there has been a marked increase in the number of blood samples testing positive for carisoprodol or meprobamate (the major metabolite)...
- The epidural and intrathecal administration of somatotrophin-release inhibiting factor: native and synthetic analoguesD P Beltrutti
Servizio di Anestesia e Rianimazione, Centro del Dolore, Ospedale S Spirito, Via Vittorio Emanuele, 3, 12042 Bra, Italy
Curr Rev Pain 4:82-90. 2000..for spinal administration, that is, epidural or intrathecal, such as the new narcotics, alpha-2 agonists, central muscle relaxants, calcitonin, and local anesthetics...
- An initially unsuspected case of baclofen overdoseGeoffrey C Wall
Iowa Methodist Medical Center, Des Moines, IA, USA
Am J Crit Care 15:611-3. 2006
- Carisoprodol, meprobamate, and driving impairmentB K Logan
Washington State Toxicology Laboratory, Washington State Patrol, Seattle 98134, USA
J Forensic Sci 45:619-23. 2000....
- Effects of intramuscular acepromazine and diazepam on tear production in rabbitsM Selk Ghaffari
Department of Clinical Studies, Islamic Azad University, Karaj, Iran
Vet Rec 164:147-8. 2009..The Schirmer tests were repeated after 15 and 25 minutes. There was a significant reduction in tear production by the rabbits treated with acepromazine, but no significant change in tear production by the rabbits treated with diazepam...
- Persistent heartburn in a patient on proton-pump inhibitorRonnie Fass
The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
Clin Gastroenterol Hepatol 6:393-400. 2008
- A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S geneP Jason Toppin
Department of Anesthesia and Pain Management, Toronto General Hospital, University of Toronto, ON, Canada
Can J Anaesth 57:689-93. 2010..To report the identification of a novel mutation in the CACNA1S gene that encodes the alpha-1-subunit (Cav1.1) of the voltage-gated skeletal muscle L-type calcium channel in a patient with malignant hyperthermia...
- Comparison between effects of dantrolene and nifedipine on lipopolysaccharide-induced endotoxemia in the anesthetized ratsC C Wu
Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, ROC
Chin J Physiol 42:211-7. 1999..Thus, both dantrolene and nifedipine have beneficial hemodynamic effects, although through different mechanisms, in animals with endotoxic shock...
- Cardiac surgery in the parturientShobana Chandrasekhar
Baylor College of Medicine Division of Cardiovascular Anesthesiology at the TX Heart Institute, St Luke s Episcopal Hospital, 6720 Bertner Ave, Houston, TX 77030, USA
Anesth Analg 108:777-85. 2009..5 L x min(-1) x m(-2) and perfusion pressure >70 mm Hg; 2) maintaining the hematocrit > 28%; 3) using normothermic perfusion when feasible; 4) using pulsatile flow; and 5) using alpha-stat pH management...
- Neuroleptic malignant syndrome from central nervous system insult: 4 cases and a novel treatment strategy. Clinical articleScott D Wait
Divisions of Neurological Surgery, Barrow Neurological Institue, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
J Neurosurg Pediatr 4:217-21. 2009..Alleviation of any CNS insult is the first order of treatment. Some patients with persistent symptoms of NMS may benefit from intrathecal delivery of baclofen...
- Stability-indicating HPLC method for the determination of impurities in meprobamate with refractive index detectionK Karthikeyan
Analytical Development, Shasun Research Center, Chennai 600048, India
J Chromatogr Sci 48:212-8. 2010..1%. Good linearity (r(2) > 0.99) and precision (RSD < 2.2%) have been obtained for MEP, MP0, and MP1. This method has been applied successfully to determine the content of impurities in MEP bulk drug...
- Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladderSoon Chul Myung
Research Institute for Translational System Biomics, Chung Ang University, College of Medicine, Seoul, South Korea
J Sex Med 5:1088-96. 2008..Aims. However, there has been no basic research to clarify the relationship between OAB and female sexual dysfunction. Therefore, we investigated this issue using a rabbit model of OAB...
- Carisoprodol intoxications: a retrospective study of forensic autopsy material from 1992-2003Gudrun Høiseth
Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, P O Box 4404, Nydalen, 0403 Oslo, Norway
Int J Legal Med 121:403-9. 2007..There were, however, only a small number of cases where the cause of death can be attributed to use of carisoprodol alone...
- [Efficacy of intrathecal baclofen in the treatment of spasticity in stroke]D Lamotte
Service de Medecine Physique et de Readaptation, hôpital Reine Hortense, boulevard Berthollet, 73100 Aix les Bains, France
Ann Readapt Med Phys 50:165-9. 2007..To determine whether intrathecal administration of baclofen reduced spastic hypertonia in a hemiplegic patient after hemorrhagic stroke...
- Management and rehabilitation of neuropathic bladder in patients with spinal cord lesionC A Rapidi
Neuropathic Bladder Unit, Rehabilitation Department, National Rehabilitation Center, Athens, Greece
Acta Neurochir Suppl 97:307-14. 2007..All efforts should be directed towards the functional integrity of the upper urinary tract and the acquirement of the greatest possible independence for the patient...
- Blockers of monoamine transporters influence high dopamine concentration uptake in rat brain slicesM Yu Iniouchine
Department Physiology, School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
Dokl Biol Sci 419:80-2. 2008
- [Use of local injections of tolperisone (midocalm) in combination with tractional therapy in the treatment of vertebral static syndrome]Ia Iu Zakharov
Zh Nevrol Psikhiatr Im S S Korsakova 107:30-4. 2007..A quantitative assessment revealed that in the indexed group treatment efficacy was 1,56 times higher and the effect achieved sooner than in the comparison group...
- Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermiaDawei Jiang
Libin Cardiovascular Institutes of Alberta, Department of Physiology, University of Calgary, Calgary, Alberta, Canada
J Biol Chem 283:20813-20. 2008..Together, our data support a view in which altered luminal Ca(2+) regulation of RyR1 represents a primary causal mechanism of MH...
- Recurrent transient global amnesia with intrathecal baclofenLucinda A Grande
Department of Anesthesiology, Box 356540, University of Washington School of Medicine, Seattle, WA 98195, USA
Anesth Analg 106:1284-7, table of contents. 2008..Baclofen-induced amnesia in rodents is a reliable model of memory impairment. In contrast, baclofen-induced memory impairment in humans is uncommon. Baclofen- associated transient global amnesia has not previously been reported...
- Incidence and identification of intrathecal baclofen catheter malfunctionEric M Dvorak
Department of Physical Medicine and Rehabilitation, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
PM R 2:751-6. 2010..An internal review was performed to develop a diagnostic flow chart to have a systematic method for identifying ITB pump and catheter complications...
- Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndromeP J Medina
Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy and Hematology Oncology Section, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73190, USA
Curr Opin Hematol 8:286-93. 2001..Recognition of a drug-associated etiology in a patient with TTP-HUS is critical to avoid re-exposure and recurrent illness...
- Atypical neuroleptic malignant syndrome caused by clozapine and venlafaxine: early brief treatment with dantroleneVittorio Ferioli
Can J Psychiatry 49:497-8. 2004
- Clinical inquiries. Does quinine reduce leg cramps for young athletes?Noelle Robertson
Moses Cone Health System, Greensboro, NC, USA
J Fam Pract 54:76-8. 2005
- [Placental passage of anesthetics and adjuvants]C Lang
Klinik für Anästhesie und Intensivtherapie, Klinikum, Philipps Universitat Marburg, Baldingerstrasse, 35033 Marburg
Anaesthesist 51:409-17. 2002....
- Bifid condyle: case reportGuadalupe Corchero-Martín
Med Oral Patol Oral Cir Bucal 10:277-9. 2005..Treatment is conservative for symptomatic patients with TMJ disorders, surgical treatment is described in literature in TMJ ankylosis that develops in bifid condyles secondary to trauma...
- GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) ratsCarla Lobina
Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
Brain Res Brain Res Protoc 15:1-5. 2005....
- Exacerbating factors in neuroleptic malignant syndrome: comparisons between cases with death, sequelae, and full recoveryMasanori Nagamine
J Clin Psychopharmacol 25:499-501. 2005
- Volume of the effect compartment in simulations of neuromuscular blockVladimir Nigrovic
Department of Anesthesiology, Medical University of Ohio, Toledo, OH, USA
Theor Biol Med Model 2:41. 2005..The study examines the role of the volume of the effect compartment in simulations of neuromuscular block (NMB) produced by nondepolarizing muscle relaxants...
- Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in ratsS R R Hall
Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
Am J Transplant 5:2862-9. 2005..Dantrolene without mannitol was without effect. Since mannitol exhibits free radical scavenging properties, protection could be the result of a decrease in oxidative stress after intra-cranial hypertension...
- Transverse myelitis associated with restless legs syndrome and periodic movements of sleep responsive to an oral dopaminergic agent but not to intrathecal baclofenL K Brown
The University of Arizona College of Medicine, Tucson, AZ, USA
Sleep 23:591-4. 2000..All symptoms of RLS/PLMD resolved after treatment with pergolide...
- Mechanisms of comorbidity between epilepsy and depressionAndrey M Mazarati; Fiscal Year: 2010..Advancement of knowledge in this area will likely contribute to the development of effective therapy and the improvement of quality of life in those patients who suffer from both epilepsy and depression. ..
- Discriminative Stimulus Effects of Alcohol in MiceWouter Koek; Fiscal Year: 2007..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
- Thymectomy in Non-Thymomatous MG Patients on PrednisoneCamilla Buckley; Fiscal Year: 2007..Subgroup analysis may show whether benefits are confined to those who are prednisone naive at entry or in a particular age group. Thus the results will impact on current clinical practice. ..
- Rehabilitation Medicine Scientist Training (RMST) ProgramJohn Whyte; Fiscal Year: 2007....
- Research Methods for Cognitive RehabilitationJohn Whyte; Fiscal Year: 2007..Importantly, a subject recruitment infrastructure within the Core will make it feasible for visiting or remote collaborators to identify appropriate subjects for study during brief research visits. [unreadable] [unreadable]..
- Leupeptin in a Canine Model of Duchenne Muscular DystrophyMARTIN CHILDERS; Fiscal Year: 2006..Specific Aim #4b: Compare lean body muscle mass and calpain activity between leupeptin and placebo-treated GRMD dogs. ..
- Abused Inhalant Actions at GABA and Glutamate SynapsesM MacIver; Fiscal Year: 2007..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane and trichloroethylene. ..
- CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger PathwaysKIM BLACKWELL; Fiscal Year: 2007..Thus, the results of this research may help in the development of treatments for alcohol addiction. ..
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2007....
- Local Immunosuppression for Liver TransplantationReza Mehvar; Fiscal Year: 2007..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2007..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- Agonist Activity at G Protein Coupled ReceptorsFRED EHLERT; Fiscal Year: 2007..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
- CRCNS: Spatio-temporal Dynamics Dopamine Activated PathKIM BLACKWELL; Fiscal Year: 2005..Thus, the results of this research may help in the development of treatments for alcohol addiction. ..
- Physical and Pharmacological Effects on Movement in SCITHOMAS HORNBY; Fiscal Year: 2006..As a consequence of these findings, a radical change in pharmacological management of motor incomplete SCI will be indicated. ..
- Local Immunosuppression for Liver TransplantationReza Mehvar; Fiscal Year: 2006..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
- Agonist Activity at G Protein Coupled ReceptorsFRED EHLERT; Fiscal Year: 2008..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
- Local Immunosuppression for Liver TransplantationReza Mehvar; Fiscal Year: 2008..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
- CRCNS: Spatial & Temporal Aspects of cAMP/PKA Signaling Underlying InformationKIM L contact BLACKWELL; Fiscal Year: 2010..Successful completion of the research will form the basis for investigating how alterations in this pathway contributes to psychiatric disease such as schizophrenia and alcoholism. ..
- Vulnerability to Opioids: A Mouse ModelWouter Koek; Fiscal Year: 2010....
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2010....
- Vulnerability to Opioids: A Mouse ModelWouter Koek; Fiscal Year: 2009....
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2009..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- CRCNS: Spatial & Temporal Aspects of cAMP/PKA Signaling Underlying InformationKIM BLACKWELL; Fiscal Year: 2009..Successful completion of the research will form the basis for investigating how alterations in this pathway contributes to psychiatric disease such as schizophrenia and alcoholism. ..
- Abused Inhalant Actions at GABA and Glutamate SynapsesM MacIver; Fiscal Year: 2008..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane andtrichloroethylene. ..
- CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger PathwaysKIM BLACKWELL; Fiscal Year: 2009..Thus, the results of this research may help in the development of treatments for alcohol addiction. ..
- Methodology CoreSheila Muldoon; Fiscal Year: 2008..In addition, they will collect muscle samples to make myoblast cultures to be purified by Core B, and flash freeze discarded muscle samples for transcriptional profiling studies. ..
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2009....
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2008..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- Validation of High-Throughput Screening of Candidate Antiepileptogenic DrugsAndrey Mazarati; Fiscal Year: 2008..The current project is designed to introduce and validate an animal model of epileptogenesis that would allow for the quick and effective screening of emerging antiepileptogenic drugs on a large scale. ..
- Abused Inhalant Actions at GABA and Glutamate SynapsesM MacIver; Fiscal Year: 2008..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane and trichloroethylene. ..
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2008....
- CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger PathwaysKIM BLACKWELL; Fiscal Year: 2008
- Agonist Activity at G Protein Coupled ReceptorsFRED EHLERT; Fiscal Year: 2006..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
- BRAIN GALANIN RECEPTORS AND EPILEPSYAndrey Mazarati; Fiscal Year: 2006..abstract_text> ..
- AIRWAY PROTECTION DURING VOMITINGIvan Lang; Fiscal Year: 2002..Finally, the relative contribution of peripheral reflexes and direct central nervous system control over the motor events that comprise vomiting will be studied. ..
- BRAIN GALANIN RECEPTORS AND EPILEPSYAndrey Mazarati; Fiscal Year: 2003....
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2003..By identifying the role of specific receptors in abuse-related effects of GHB, future studies may be better able to develop specific, pharmacologically targeted therapies for GHB abuse. ..
- MUSCLE RESPONSE TO STRESS IN CANINE MUSCULAR DYSTROPHYMARTIN CHILDERS; Fiscal Year: 2002..It is anticipated that findings will improve the understanding of how dystrophic muscle responds to physical stress resulting in improved treatment for patients with Duchenne muscular dystrophy. ..
- SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURYMartin Marsala; Fiscal Year: 2001..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 2001..abstract_text> ..
- SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURYMartin Marsala; Fiscal Year: 2000..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 2000..Parallel studies will determine the extent to which an anesthetic-induced depression of CA 1 neuron discharge can be reversed by blocking GABA receptor/Cl- channels. ..
- SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURYMartin Marsala; Fiscal Year: 1999..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2002....
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2003....
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 2003..abstract_text> ..
- Abused Inhalant Actions at GABA and Glutamate SynapsesM MacIver; Fiscal Year: 2005..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane and trichloroethylene. ..
- Local Immunosuppression for Liver TransplantationReza Mehvar; Fiscal Year: 2005
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2005..By identifying the role of specific receptors in abuse-related effects of GHB, future studies may be better able to develop specific, pharmacologically targeted therapies for GHB abuse. ..
- MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCHDavid Simpson; Fiscal Year: 2005..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2005....
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 2004..abstract_text> ..
- PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITSJohn Whyte; Fiscal Year: 2003..The factor structure will also be compared to that obtained from a control sample. ..
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2004....
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2004..By identifying the role of specific receptors in abuse-related effects of GHB, future studies may be better able to develop specific, pharmacologically targeted therapies for GHB abuse. ..
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2010
- Abused Inhalant Actions at GABA and Glutamate SynapsesM MacIver; Fiscal Year: 2006
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 1999..Parallel studies will determine the extent to which an anesthetic-induced depression of CA 1 neuron discharge can be reversed by blocking GABA receptor/Cl- channels. ..
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 2002..abstract_text> ..
- Vulnerability to Opioids: A Mouse ModelWouter Koek; Fiscal Year: 2008....
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2006....
- SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURYMartin Marsala; Fiscal Year: 2000
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2002....