central muscle relaxants

Summary

Summary: A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)

Top Publications

  1. pmc Cooling methods used in the treatment of exertional heat illness
    J E Smith
    Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
    Br J Sports Med 39:503-7; discussion 507. 2005
  2. ncbi GMFM 1 year after continuous intrathecal baclofen infusion
    Linda E Krach
    Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
    Pediatr Rehabil 8:207-13. 2005
  3. ncbi Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in children
    A Leland Albright
    Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosurg 101:64-8. 2004
  4. ncbi Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia
    A S Burns
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spinal Cord 39:413-9. 2001
  5. ncbi [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan
    Bioorg Med Chem Lett 12:3263-5. 2002
  6. pmc Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers
    P Szentesi
    Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, H-4012
    J Gen Physiol 118:355-75. 2001
  7. ncbi Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 11:663-73. 2003
  8. ncbi Malignant hyperthermia
    M Denborough
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Lancet 352:1131-6. 1998
  9. ncbi Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen
    Jørgen Feldbaek Nielsen
    Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Clin Neurol Neurosurg 104:142-5. 2002
  10. pmc Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Moroyama machi, Saitama 350 0495, Japan
    Br J Pharmacol 134:729-36. 2001

Detail Information

Publications218 found, 100 shown here

  1. pmc Cooling methods used in the treatment of exertional heat illness
    J E Smith
    Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
    Br J Sports Med 39:503-7; discussion 507. 2005
    ..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
  2. ncbi GMFM 1 year after continuous intrathecal baclofen infusion
    Linda E Krach
    Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
    Pediatr Rehabil 8:207-13. 2005
    ..05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved...
  3. ncbi Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in children
    A Leland Albright
    Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosurg 101:64-8. 2004
    ....
  4. ncbi Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia
    A S Burns
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spinal Cord 39:413-9. 2001
    ..CONCLUSIONS: Intrathecal baclofen is a safe and effective intervention for treating upper extremity hypertonia of spinal origin. In addition, the level of intrathecal catheter placement is felt to be of importance...
  5. ncbi [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan
    Bioorg Med Chem Lett 12:3263-5. 2002
    ....
  6. pmc Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers
    P Szentesi
    Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, H-4012
    J Gen Physiol 118:355-75. 2001
    ..The channel displayed a constant open probability for as long as 30-50 min after the application of the drug. These data locate the binding site for dantrolene to be on the SR membrane, but be distinct from the purified RYR itself...
  7. ncbi Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 11:663-73. 2003
    ....
  8. ncbi Malignant hyperthermia
    M Denborough
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Lancet 352:1131-6. 1998
    ..By far the most common is inherited as a mendelian dominant characteristic and at present mutations in the human RYR account for no more than 20% of susceptible families...
  9. ncbi Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen
    Jørgen Feldbaek Nielsen
    Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Clin Neurol Neurosurg 104:142-5. 2002
    ..Complications are often due to infection or catheter problems...
  10. pmc Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Moroyama machi, Saitama 350 0495, Japan
    Br J Pharmacol 134:729-36. 2001
    ..8. These results indicate that the difference in opening modes of the RyR-Ca(2+) release channel is recognized by certain Dan derivatives...
  11. ncbi Myofascial pain disorders: theory to therapy
    Anthony H Wheeler
    Pain and Orthopedic Neurology, Charlotte Spine Center, Charlotte, North Carolina 28207, USA
    Drugs 64:45-62. 2004
    ..Chronic myofascial pain is usually a product of both physical and psychosocial influences that complicate convalescence...
  12. pmc Managing an effective treatment for neuroleptic malignant syndrome
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Crit Care 11:R4. 2007
    ..The aim of this study was to prove the efficacy of different NMS treatment strategies, focusing on the efficacy of dantrolene...
  13. ncbi Effects of dantrolene on rat diaphragm muscle during postnatal maturation
    G Orliaguet
    Department of Anesthesiology, Centre Hospitalo-Universitaire Necker-Enfants Malades, Paris, France
    Anesthesiology 94:468-74. 2001
    ..Our study suggests that developmental changes in the pharmacologic response to dantrolene are more rapid than those of ryanodine...
  14. ncbi Intrathecal baclofen in the management of spasticity due to cerebral palsy
    Michael Vloeberghs
    Queens Medical Centre, Nottingham, UK
    Pediatr Rehabil 8:172-9. 2005
    ..However, further research is required to set criteria for treatment. This paper offers insight into the national act on baclofen and the experience at the Nottingham University Hospital...
  15. ncbi A clinical study of intrathecal baclofen using a programmable pump for intractable spasticity
    Daniel Guillaume
    Centre Neurologique et de Réadaptation Fonctionnelle, Fraiture en Condroz, Belgium
    Arch Phys Med Rehabil 86:2165-71. 2005
    ..To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity...
  16. ncbi Baclofen toxicity in an 8-year-old with an intrathecal baclofen pump
    Ronald N Yeh
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Emerg Med 26:163-7. 2004
    ..This report describes the clinical presentation, unfamiliar dilemmas, and the management of a pediatric patient with intrathecal baclofen toxicity, noting problems that may arise in the care of these patients...
  17. ncbi Pharmacologic interventions for reducing spasticity in cerebral palsy
    Dilip R Patel
    Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
    Indian J Pediatr 72:869-72. 2005
    ....
  18. ncbi Long-term intrathecal baclofen therapy in ambulatory patients with spasticity
    Saud A Sadiq
    MS Research and Treatment Center of New York, Albert Einstein College of Medicine, 425 West 59th Street, Suite 7C, New York, NY 10019, USA
    J Neurol 253:563-9. 2006
    ..This retrospective study is designed to determine the long-term ambulatory function in patients receiving ITB...
  19. ncbi Epilepsy and intrathecal baclofen therapy in children with cerebral palsy
    Vincenzo Buonaguro
    Department of Paediatric Orthopedics, Children s Hospital V Buzzi, Milan, Italy
    Pediatr Neurol 33:110-3. 2005
    ..We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity...
  20. ncbi Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study
    Gerard E Francisco
    Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas Houston Medical School, Houston, TX, USA
    Arch Phys Med Rehabil 84:1194-9. 2003
    ..To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors...
  21. ncbi Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literature
    B M Soni
    Regional Spinal Injuries Centre, Southport and Ormskirk NHS Trust, Southport, UK
    Spinal Cord 41:586-9. 2003
    ..Case report...
  22. ncbi [Intrathecal baclofen in severe spasticity due to multiple sclerosis]
    Jarosław Sławek
    Kliniki Neurochirurgii Akademii Medycznej w Gdańsku
    Neurol Neurochir Pol 37:1135-42; discussion 1143. 2003
    ..At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted...
  23. ncbi Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patients
    R Plassat
    Department of Physical Medicine and Rehabilitation, CHU Angers, France
    Spinal Cord 42:686-93. 2004
    ..Case series of a consecutive sample. Retrospective audit...
  24. ncbi Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump function
    Martin O'Connell
    Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Nucl Med 29:578-80. 2004
  25. pmc Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin
    A Zahavi
    Department of Rehabilitation, University Groningen, Netherlands
    J Neurol Neurosurg Psychiatry 75:1553-7. 2004
    ..To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen...
  26. ncbi Salvage of baclofen pump pocket infection with muscle flap
    Bishara S Atiyeh
    Plast Reconstr Surg 114:1661-3. 2004
  27. ncbi [Intrathecal baclofen for treatment of spasticity in patient with cerebral palsy--a preliminary report]
    Marek Jozwiak
    Klinika Ortopedii Dzieciecej, Akademia Medyczna im Karola Marcinkowskiego w Poznaniu
    Chir Narzadow Ruchu Ortop Pol 68:253-9. 2003
    ..Early results of spasticity treatment in cerebral palsy with intrathecal baclofen infusions are very promising...
  28. ncbi Implantable baclofen pump as an adjuvant in treatment of pressure sores
    Sarah A Mess
    Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA
    Ann Plast Surg 51:465-7. 2003
    ..Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients...
  29. ncbi Dosage of intrathecal baclofen maintenance therapy in the spastic syndromes
    Youssef Fares
    Neurosurgical Service, Ntra Sra Clinic of the Conception Jimenez Diaz Foundation, Madrid, Spain
    J Med Liban 52:13-8. 2004
    ..81 microg/day in the final phase. These doses were higher in patients with medullary traumatic lesion, diffuse cerebral lesion and spastic idiopathic paraparesis. Relatively mild side effects were produced by the therapeutic doses used...
  30. ncbi Placement of baclofen pumps through the foramen magnum and upper cervical spine
    Kristine Dziurzynski
    Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Childs Nerv Syst 22:270-3. 2006
    ..As an alternative to placing the pump catheter through the lumbar spine, we report our experience with placement of the catheter in the spinal canal via a cervical approach through the foramen magnum...
  31. ncbi Quality of life of patients with telemetric pumps for intrathecal baclofen infusion: data and limitations of assessment scales
    Placido Bramanti
    Centro Studi Neurolesi, University of Messina, Italy
    Funct Neurol 19:227-31. 2004
    ..These results encourage us to continue this study in a larger patient sample, considering different types of pathology and presence/absence of caregivers...
  32. ncbi [Treatment of severe spacticity in multiple sclerosis by continuous intrathecal baclofen]
    Predrag Peric
    Vojnomedicinska akademija, Klinika za neurohirurgiju, Beograd, Srbija i Crna Gora
    Vojnosanit Pregl 63:187-91. 2006
    ..Continuous intrathecal administration of baclofen (ITB), using a subcutaneously implanted programmable infusion pump, is a minimally invasive, reversible method for the treatment of severe diffuse spasticity of the spinal origin...
  33. ncbi Best-practice surgical techniques for intrathecal baclofen therapy
    A Leland Albright
    Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
    J Neurosurg 104:233-9. 2006
    ..Panel members advocate the aforementioned techniques to improve the efficacy of and decrease the morbidity associated with ITB therapy...
  34. ncbi Intrathecal baclofen for the treatment of spasticity
    I Dones
    Department of Neurosurgery, Instituto Nazionale Neurologico C Besta, Via Celoria, Milano, Italy
    Acta Neurochir Suppl 97:185-8. 2007
    ..Currently, treatment of spasticity with ITB is the most effective way of reducing spasticity regardless of its cause...
  35. ncbi Surgical management of spasticity of cerebral origin in children
    S Sgouros
    Department of Neurosurgery, Birmingham Children s Hospital, Birmingham, UK
    Acta Neurochir Suppl 97:193-203. 2007
    ..Current pumps have practical limitations but, in the next decade, it is anticipated that technological improvements will render the pumps more patient friendly...
  36. ncbi Opisthotonus and intrathecal treatment with baclofen (ITB) in children
    Berten Ceulemans
    Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
    Eur J Pediatr 167:641-5. 2008
    ..This increase in weight might be due to a reduction in energy expenditure as a result of the decrease in spasticity. Intrathecal treatment with baclofen should be considered in every child with opisthotonus...
  37. ncbi Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief
    Shearwood McClelland
    Department of Neurosurgery, University of Minnesota Medical School, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Muscle Nerve 37:396-8. 2008
    ..Postoperative pain reduction was predicted by the degree of pain reduction following preoperative ITB test injection. These results support ITB as a treatment modality for pain associated with spasticity in ALS...
  38. ncbi Infusion of intrathecal baclofen for acute withdrawal. Technical note
    Bradley S Duhon
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Neurosurg 107:878-80. 2007
    ..In both cases, the patients recovered to their neurological baseline level, and lasting consequences of serious withdrawal were avoided...
  39. ncbi Functional effects of spinal baclofen
    Hermann Muller
    Dpt Anesthesiology, Intensive Care and Pain Therapy, Kemperhof Hospital, Koblenz, Germany
    Przegl Lek 64:1-2. 2007
  40. ncbi [Baclofen dose in a screening test and in a baclofen pump filling--is there any differences]
    Przemysław Grzegorzewski
    Oddział Neurochirurgii, Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:8-12. 2007
    ..In this study we compared a bolus intrathecal injection given in a screening test with doses uses for filling a baclofen pump. In selected group we observed increased Baclofen dose due to dose given in screening test...
  41. ncbi [Assessment of spasticity therapy with baclofen pump in children]
    Anna Swierczyńska
    Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:15-7. 2007
    ..The aim of this study was to assess of treatment of spasticity in children with baclofen pump, before and after pump implantation...
  42. ncbi [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]
    Alicja Fafara
    Oddział Neurochirurgii Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:18-21. 2007
    ..It results also in improvement of patients and their families quality of life. The aim of study was to assess the effects after baclofen pump implantation due to parents expectations...
  43. ncbi Combined treatment with BTX-A and ITB for spasticity: case report
    Chandler E Gill
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
    Tenn Med 100:41-2, 44. 2007
    ..Expanded investigations should be carried out to evaluate the efficacy of combined therapy in patients with mental retardation...
  44. ncbi A review of the complications of intrathecal baclofen in patients with cerebral palsy
    Kat Kolaski
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    NeuroRehabilitation 22:383-95. 2007
    ..However, until we have consistent, reliable reports of complications, it will not be possible to perform specific risk/benefit analyses. Recommendations for improving investigation in this important area are discussed...
  45. ncbi Intrathecal antispastic drug application with implantable pumps: results of a 10 year follow-up study
    A Koulousakis
    Department of Neurosurgery, Cologne University, Cologne, Germany
    Acta Neurochir Suppl 97:181-4. 2007
    ..Destructive procedures such as myelotomy are no longer performed in our department in order to treat spasticity...
  46. ncbi Intrathecal baclofen therapy in patients with severe spasticity
    G A Marra
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Acta Neurochir Suppl 97:173-80. 2007
    ..These treatments, do not resolve spasticity in about 33% of cases. In these severe cases, more invasive procedures such as muscle infiltrations with botulin toxin and intrathecal baclofen infusion can be used...
  47. ncbi The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive cases
    Francesco Motta
    Department of Paediatric Orthopaedics, V Buzzi Children s Hospital, Milan, Italy
    J Neurosurg 107:32-5. 2007
    ..The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants...
  48. ncbi Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticity
    Dobrivoje S Stokic
    Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA
    Clin Neurophysiol 117:1283-9. 2006
    ..To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia...
  49. ncbi Intrathecal baclofen therapy: ten steps toward best practice
    Barbara Ridley
    Alta Bates Summit Medical Center, Berkeley, CA, USA
    J Neurosci Nurs 38:72-82. 2006
    ....
  50. ncbi [Coma induced by an overdose of intrathecal baclofen]
    H Alonso-Navarro
    Rev Neurol 43:63-4. 2006
  51. ncbi Intrathecal baclofen therapy in children
    A Leland Albright
    Department of Neurosurgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
    Neurosurg Focus 21:e3. 2006
    ..Additional investigation is needed to determine the effects of ITB on other movement disorders such as athetosis and chorea...
  52. ncbi Intrathecal baclofen in the treatment of adult spasticity
    Joseph C Hsieh
    Section of Neurosurgery, University of Chicago, Illinois 60637, USA
    Neurosurg Focus 21:e5. 2006
    ..In this paper the authors survey the use of oral and intrathecal baclofen therapy, detail the surgical process, and explain the risks and benefits of the procedure...
  53. ncbi Continuous intrathecal baclofen administration by a fully implantable electronic pump for severe spasticity treatment: our experience
    A Guglielmino
    Anesthesia and Intensive Care Unit, Polyclinic University Hospital of Catania, Catania, Italy
    Minerva Anestesiol 72:807-20. 2006
    ....
  54. ncbi Intrathecal baclofen for muscle spasticity and pain--two case reports
    Dhafir Al Khudhairi
    Sultan Bin Abdelaziz Humanitarian Centre and Riyadh Armed Forces Hospital, Saudi Arabia
    Middle East J Anesthesiol 18:971-6. 2006
  55. ncbi [Management of increase in spasticity in patients with intrathecal baclofen pumps]
    N Roche
    Service de médecine physique et réadaptation, Hopital Raymond Poincare, APHP, Universite de Versailles Saint Quentin, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Ann Readapt Med Phys 50:93-9. 2007
    ..Diagnosis of these complications can be difficult. A diagnostic tree would be a useful tool in cases of suspected malfunctioning of the intrathecal bacolfen infusion system and would standardise the diagnostic procedure...
  56. ncbi Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 cases
    K D Ethans
    Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Spinal Cord 43:214-8. 2005
    ..The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail...
  57. ncbi Interaction of ventriculoperitoneal shunt and baclofen pump
    Daniel H Fulkerson
    Pediatric Neurosurgery Service, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 1134, Indianapolis, IN 46202, USA
    Childs Nerv Syst 23:733-8. 2007
    ..The authors present three cases of children with shunted hydrocephalus and intrathecal delivery of baclofen via an implanted pump. Each case illustrates a potential interaction of these devices...
  58. ncbi Inflammatory mass of an intrathecal catheter in patients receiving baclofen as a sole agent: a report of two cases and a review of the identification and treatment of the complication
    Timothy R Deer
    The Center for Pain Relief, Charleston, West Virginia and Department of Anesthesiologoy, West Virginia University, Charleston, West Virginia 25301, USA
    Pain Med 8:259-62. 2007
    ..Intrathecal baclofen has been used to treat spasticity secondary to stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and other neurological disease...
  59. ncbi Intrathecal baclofen therapy in adults and guideline for clinical nursing care
    Rozina Bhimani
    Sister Kenny Rehabilitation Associates, Abbott Northwestern Hospital, Minneapolis, MN, USA
    Rehabil Nurs 33:110-6. 2008
    ..A fundamental understanding of the intrathecal baclofen pump allows nurses to provide cutting-edge technological and individualized care with compassion...
  60. ncbi Intrathecal baclofen withdrawal mimicking sepsis
    Louise W Kao
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Emerg Med 24:423-7. 2003
    ..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
  61. ncbi Intrathecal baclofen therapy in children with cerebral palsy
    Ted R Brown
    Arch Phys Med Rehabil 84:624; author reply 624. 2003
  62. ncbi Intrathecal baclofen withdrawal: a case report and review of the literature
    Tord D Alden
    Department of Neurosurgery, St Louis Children s Hospital, One Children s Place, Suite 4S20, Washington University School of Medicine, MO 63110, USA
    Childs Nerv Syst 18:522-5. 2002
    ..Withdrawal from oral baclofen has been well described. Intrathecal baclofen withdrawal has been less frequently reported. We present a case of withdrawal after intrathecal baclofen pump catheter failure...
  63. ncbi Cyproheptadine for intrathecal baclofen withdrawal
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
    Arch Phys Med Rehabil 84:638-42. 2003
    ..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
  64. ncbi Subfascial implantation of intrathecal baclofen pumps in children: technical note
    B H Kopell
    Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 49:753-6; discussion 756-7. 2001
    ..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
  65. ncbi Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: a descriptive pilot study
    Kristie F Bjornson
    Children s Hospital and Regional Medical Center, Neurodevelopmental Clinic, Spasticity Management Clinic, Seattle, WA, USA
    Arch Phys Med Rehabil 84:500-6. 2003
    ..To describe the oral motor, communication, and nutritional status of children receiving intrathecal baclofen (ITB) therapy for spasticity of cerebral origin...
  66. ncbi Intrathecal baclofen for spasticity management in Rett syndrome
    Vivek Kadyan
    Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA
    Am J Phys Med Rehabil 82:560-2. 2003
    ..The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome...
  67. ncbi Intrathecal baclofen for spasticity caused by thrombotic stroke
    B L Gwartz
    Pain Diagnosis and Treatment, Inc, Glendora, CA 91741-4205, USA
    Am J Phys Med Rehabil 80:383-7. 2001
    ..The patient achieved substantial functional gains as well as improved ease of care, quality of life, and cessation of narcotic use...
  68. ncbi Monitoring of creatinine kinase during weaning of intrathecal baclofen and with symptoms of early withdrawal
    Sam C Colachis
    Department of Physical Medicine and Rehabilitation and SCI Rehabilitation, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Phys Med Rehabil 82:489-92. 2003
    ....
  69. ncbi On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966
    B A McMillen
    Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC
    J Neural Transm Gen Sect 89:11-25. 1992
    ..Thus, the effects of these muscle relaxants on DA neurons are mediated by a mechanism other than strychnine-insensitive glycine or GABAb receptors...
  70. ncbi [Centrally acting muscle relaxants and traffic hazards]
    J G Bramness
    Statens rettstoksikologiske institutt, Oslo
    Tidsskr Nor Laegeforen 120:1966-9. 2000
    ..In later years there has been a marked increase in the number of blood samples testing positive for carisoprodol or meprobamate (the major metabolite)...
  71. ncbi The epidural and intrathecal administration of somatotrophin-release inhibiting factor: native and synthetic analogues
    D P Beltrutti
    Servizio di Anestesia e Rianimazione, Centro del Dolore, Ospedale S Spirito, Via Vittorio Emanuele, 3, 12042 Bra, Italy
    Curr Rev Pain 4:82-90. 2000
    ..for spinal administration, that is, epidural or intrathecal, such as the new narcotics, alpha-2 agonists, central muscle relaxants, calcitonin, and local anesthetics...
  72. ncbi [Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine]
    C Boido Canu
    Istituto di Scienze Farmaceutiche,
    Farmaco Sci 43:819-37. 1988
    ..Interesting levels of activity were exhibited in several cases...
  73. ncbi A survey of the practice of electroconvulsive therapy in Asia
    Worrawat Chanpattana
    Department of Psychiatry, Samitivej Srinakarin Hospital, Bangkok, Thailand
    J ECT 26:5-10. 2010
    ..To describe a comprehensive survey of the practice of electroconvulsive therapy (ECT) in Asia...
  74. ncbi Do we need a new muscle relaxant in paediatrics?
    Nishan Goudsouzian
    Paediatr Anaesth 13:1-2. 2003
  75. ncbi GW280430A
    Goetz F Geldner
    Anesthesiology 102:861; author reply 862-5. 2005
  76. ncbi Pharmacological properties of NK433, a new centrally acting muscle relaxant
    K Sakitama
    Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co Ltd, Tokyo, Japan
    Eur J Pharmacol 273:47-56. 1995
    ..In i.v. experiments, the effects of NK433 on decerebrate rigidities were similar to those of eperisone-HCl and tolperisone-HCl, but in p.o. experiments, NK433 was at least 3 times as potent as eperisone-HCl and tolperisone-HCl...
  77. ncbi Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells
    Yen Chin Liu
    Department of Anesthesiology, Kaohsiung Veterans General Hospital, City, Kaohsiung, Taiwan
    Brain Res 959:86-97. 2003
    ..The stimulatory effects of chlorzoxazone on these channels may be responsible for the underlying mechanism of chlorzoxazone actions on neurons and neuroendocrine cells...
  78. ncbi CYP2E1 expression in human lymphocytes from various ethnic populations
    J L Raucy
    Agouron Institute, University of New Mexico School of Medicine, USA
    Alcohol Clin Exp Res 23:1868-74. 1999
    ..We previously demonstrated that lymphocyte CYP2E1 expression reflects in vivo activity of the hepatic enzyme...
  79. ncbi [Baclofen-associated encephalopathy in a hemodialysis patient with hiccups]
    L F Quintana
    Servicio de Nefrologia y Trasplante Renal, Hospital Clinic, Barcelona
    Nefrologia 26:486-8. 2006
    ..We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose...
  80. pmc Outcome of non-invasive treatment modalities on back pain: an evidence-based review
    Maurits W van Tulder
    Institute for Research in Extramural Medicine, EMGO, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Eur Spine J 15:S64-81. 2006
    ..Also, many trials showed methodological weaknesses, effects are compared to placebo, no treatment or waiting list controls, and effect sizes are small. Future trials should meet current quality standards and have adequate sample size...
  81. ncbi Calcium-induced calcium release and calcium buffering in retinal horizontal cells
    Eduardo Solessio
    Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City 84132, USA
    Vis Neurosci 19:713-25. 2002
    ....
  82. ncbi Regulation of ryanodine receptors by dopamine D1 receptors during methamphetamine-induced place conditioning
    Kazuhiro Kurokawa
    Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    J Neurochem 115:1206-14. 2010
    ..These findings indicate that up-regulation of RyRs is regulated through the activation of dopamine D(1) receptors in the METH-conditioning...
  83. ncbi Epidemiology of restless legs syndrome as diagnosed in UK primary care
    David A M C van de Vijver
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, P O Box 80 082, 3508 TB Utrecht, The Netherlands
    Sleep Med 5:435-40. 2004
    ..There may also be poor awareness of the condition among primary care physicians (PCPs)...
  84. ncbi Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticity
    Marcus Pohl
    Dept of Neurological Rehabilitation, Klinik Bavaria, An der Wolfsschlucht 1 2, 01731 Kreischa, Germany
    J Neurol 250:1195-200. 2003
    ..5 hours, with a maximal effect at 4 hours after intrathecal baclofen injection. Clinical scales used to determine the effect of BBT should thus be carried out during this period-ideally at 4 hours after baclofen injection...
  85. pmc Quinine intoxications: a continuing problem
    S Taylor
    Br J Clin Pharmacol 57:817; author reply 817. 2004
  86. ncbi [Case of oromandibular dystonia presenting with severe impairment of mouth-opening, and a marked effect by administration of baclofen]
    Masamichi Ikawa
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
    Rinsho Shinkeigaku 46:661-3. 2006
    ..Her clinical symptoms and dystonic pattern on the surface electromyography improved markedly after the administration. Baclofen is an effective drug for treatment of oromandibular dystonia...
  87. ncbi Tics in Tourette syndrome: new treatment options
    Y Awaad
    Children s Hospital of Michigan, Movement Disorder Clinic, Wayne State University, School of Medicine, Detroit 48201, USA
    J Child Neurol 14:316-9. 1999
    ..It is worthwhile considering this treatment approach in patients with tics/Tourette's syndrome in order to reduce or avoid the side effects of other medications. Further studies, however, are required...
  88. ncbi Muscle relaxants for nonspecific low back pain: a systematic review within the framework of the cochrane collaboration
    Maurits W van Tulder
    Institute for Research in Extramural Medicine, Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 28:1978-92. 2003
    ..A systematic review of randomized and/or double-blinded controlled trials...
  89. ncbi Complications of intrathecal baclofen pump therapy in pediatric patients
    Andrzej Borowski
    Department of Orthopedics, Alfred I duPont Hospital for Children, Nemours Children s Clinic, Wilmington, DE 19899, USA
    J Pediatr Orthop 30:76-81. 2010
    ..The aim of this study was to investigate and evaluate complications of intrathecal baclofen (ITB) pump implantation and maintenance in children with cerebral palsy...
  90. ncbi Intrathecal baclofen for the treatment of tetanus
    M Lurdes Santos
    Infectious Diseases Service Intensive Care Unit, Hospital S João and School of Medicine, Porto, Portugal
    Clin Infect Dis 38:321-8. 2004
    ..Seven patients had colonization of the catheter, and 1 patient developed meningitis. All patients except one recovered. In our study, this means of treatment was efficacious and well tolerated...
  91. ncbi Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysis
    Erica C McKenzie
    Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Am J Vet Res 65:74-9. 2004
    ..To determine the effect of oral administration of dantrolene sodium on serum creatine kinase (CK) activity after exercise in horses with recurrent exertional rhabdomyolysis (RER)...
  92. ncbi Molecular cloning and functional characterization of Shaw-related potassium channels of trout CNS
    F Panofen
    Department of Animal Physiology, University of Osnabruck, Barbarastr 11 49069, Osnabruck, Germany
    Brain Res Mol Brain Res 83:9-19. 2000
    ..During brain development Traw1 mRNA was initially identified at stage 31 (shortly after hatching) while transcripts encoding Traw2 were detectable already at stage 28 (1 week before hatching)...
  93. ncbi [Diclofenac 75mg. and 30 mg. orfenadine (Neodolpasse) versus placebo and piroxicam in postoperative analgesia after arthroscopy]
    J Malek
    Klinika anesteziologie a resuscitace 3 LF UK a FNKV, Praha
    Acta Chir Orthop Traumatol Cech 71:80-3. 2004
    ..We used a new agent (Neodolpasse) based on diclophenac and orphenadine, and compared its efficacy with piroxicam and placebo...
  94. ncbi Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats
    D R Fischer
    Department of Surgery, University of Cincinnati, Ohio, USA
    Shock 15:200-7. 2001
    ..The observations are important from a clinical standpoint because they suggest that the catabolic response in skeletal muscle during sepsis may be prevented by treatment with a calcium antagonist...
  95. ncbi Benchmark data on the utilization and acquisition costs of central nervous system and muscular skeletal drugs among veterans with combat-related injuries
    Dustin D French
    James A Haley VAMC, VISN 8 Patient Safety Center of Inquiry, 13000 Bruce B Downs Boulevard 118M, Tampa, FL 33612, USA
    Mil Med 173:626-8. 2008
    ..Little is known about the utilization and costs of central nervous system (CNS) and musculoskeletal medications in veterans with blast injuries...
  96. ncbi [Trends in the agents used for euthanasia and the relationship with the number of notifications]
    M L Rurup
    VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek, afd Sociale Geneeskunde, Amsterdam
    Ned Tijdschr Geneeskd 150:618-24. 2006
    ..To provide insight into the relationship between the drugs used for euthanasia and its notification...
  97. ncbi Intrathecal baclofen in the treatment of painful, disabling spasms in Friedreich's ataxia
    Djamel Ben Smail
    Service de médecine physique et réhabilitation, Hôpital R Poincaré, 104 Boulevard R Poincaré, 92380 Garches, France
    Mov Disord 20:758-9. 2005
    ..To our knowledge, this is the first report of an intrathecal baclofen-delivering pump implantation in an FA patient...
  98. ncbi Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes
    Balazs Dalmadi
    Division of Pharmacology and Drug Safety Research, Gedeon Richter Ltd, Budapest, Hungary
    Drug Metab Dispos 31:631-6. 2003
    ..On the basis of metabolites formed and indirect evidences of inhibition studies, a considerable involvement of a microsomal reductase is assumed...
  99. ncbi Intrathecal baclofen for the treatment of spasticity of cerebral origin
    Jennifer Disabato
    Department of Child Neurology, Children s Hospital, Denver, CO, USA
    J Spec Pediatr Nurs 8:31-4. 2003
    ..Close collaboration and communication regarding the child and his/her response to ITB is essential to providing safe and effective care for this challenging population of patients...
  100. ncbi Determination of methocarbamol in equine serum and urine by high-performance liquid chromatography with ultraviolet detection and atmospheric pressure ionization-mass spectrometric confirmation
    M R Koupai-Abyazani
    Can Test Laboratories Ltd, Vancouver, British Columbia, Canada
    J Anal Toxicol 21:301-5. 1997
    ..The peak concentrations of the drug were detected 1-4 h (urine) and 10-60 min (serum) after administration to four horses. The method validation results and drug elimination profiles for both urine and serum are presented and discussed...
  101. ncbi Neuroleptic malignant syndrome associated with metoclopramide in a burn patient
    Ryan Nachreiner
    Richard M Fairbanks Burn Unit, Wishard Memorial Hospital, Indiana University, School of Medicine, Indianapolis, Indiana 46202 5124, USA
    J Burn Care Res 27:237-41. 2006
    ..It is important for burn unit personnel to be aware of this syndrome because the early institution of therapy can be life saving...

Research Grants15

  1. SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURY
    Martin Marsala; Fiscal Year: 2001
    ..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
  2. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ....
  3. Abused Inhalant Actions at GABA and Glutamate Synapses
    M MacIver; Fiscal Year: 2008
    ..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane andtrichloroethylene. ..
  4. Local Immunosuppression for Liver Transplantation
    Reza Mehvar; Fiscal Year: 2008
    ..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
  5. Agonist Activity at G Protein Coupled Receptors
    FRED EHLERT; Fiscal Year: 2008
    ..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
  6. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  7. Leupeptin in a Canine Model of Duchenne Muscular Dystrophy
    MARTIN CHILDERS; Fiscal Year: 2006
    ..Specific Aim #4b: Compare lean body muscle mass and calpain activity between leupeptin and placebo-treated GRMD dogs. ..
  8. Physical and Pharmacological Effects on Movement in SCI
    THOMAS HORNBY; Fiscal Year: 2006
    ..As a consequence of these findings, a radical change in pharmacological management of motor incomplete SCI will be indicated. ..
  9. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  10. MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCH
    David Simpson; Fiscal Year: 2005
    ..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..
  11. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....
  12. ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSES
    M MacIver; Fiscal Year: 2004
    ..abstract_text> ..
  13. PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITS
    John Whyte; Fiscal Year: 2003
    ..The factor structure will also be compared to that obtained from a control sample. ..
  14. MUSCLE RESPONSE TO STRESS IN CANINE MUSCULAR DYSTROPHY
    MARTIN CHILDERS; Fiscal Year: 2002
    ..It is anticipated that findings will improve the understanding of how dystrophic muscle responds to physical stress resulting in improved treatment for patients with Duchenne muscular dystrophy. ..
  15. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..