Genomes and Genes
central muscle relaxants
Summary: A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Publications218 found, 100 shown here
- Cooling methods used in the treatment of exertional heat illnessJ E Smith
Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
Br J Sports Med 39:503-7; discussion 507. 2005..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
- GMFM 1 year after continuous intrathecal baclofen infusionLinda E Krach
Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
Pediatr Rehabil 8:207-13. 2005..05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved...
- Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in childrenA Leland Albright
Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurosurg 101:64-8. 2004....
- Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertoniaA S Burns
Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Spinal Cord 39:413-9. 2001..CONCLUSIONS: Intrathecal baclofen is a safe and effective intervention for treating upper extremity hypertonia of spinal origin. In addition, the level of intrathecal catheter placement is felt to be of importance...
- [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscleTakamitsu Hosoya
Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan
Bioorg Med Chem Lett 12:3263-5. 2002....
- Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibersP Szentesi
Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, H-4012
J Gen Physiol 118:355-75. 2001..The channel displayed a constant open probability for as long as 30-50 min after the application of the drug. These data locate the binding site for dantrolene to be on the SR membrane, but be distinct from the purified RYR itself...
- Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscleTakamitsu Hosoya
Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
Bioorg Med Chem 11:663-73. 2003....
- Malignant hyperthermiaM Denborough
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
Lancet 352:1131-6. 1998..By far the most common is inherited as a mendelian dominant characteristic and at present mutations in the human RYR account for no more than 20% of susceptible families...
- Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofenJørgen Feldbaek Nielsen
Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
Clin Neurol Neurosurg 104:142-5. 2002..Complications are often due to infection or catheter problems...
- Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibresT Ikemoto
Department of Pharmacology, Saitama Medical School, Moroyama machi, Saitama 350 0495, Japan
Br J Pharmacol 134:729-36. 2001..8. These results indicate that the difference in opening modes of the RyR-Ca(2+) release channel is recognized by certain Dan derivatives...
- Myofascial pain disorders: theory to therapyAnthony H Wheeler
Pain and Orthopedic Neurology, Charlotte Spine Center, Charlotte, North Carolina 28207, USA
Drugs 64:45-62. 2004..Chronic myofascial pain is usually a product of both physical and psychosocial influences that complicate convalescence...
- Managing an effective treatment for neuroleptic malignant syndromeUdo Reulbach
Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Crit Care 11:R4. 2007..The aim of this study was to prove the efficacy of different NMS treatment strategies, focusing on the efficacy of dantrolene...
- Effects of dantrolene on rat diaphragm muscle during postnatal maturationG Orliaguet
Department of Anesthesiology, Centre Hospitalo-Universitaire Necker-Enfants Malades, Paris, France
Anesthesiology 94:468-74. 2001..Our study suggests that developmental changes in the pharmacologic response to dantrolene are more rapid than those of ryanodine...
- Intrathecal baclofen in the management of spasticity due to cerebral palsyMichael Vloeberghs
Queens Medical Centre, Nottingham, UK
Pediatr Rehabil 8:172-9. 2005..However, further research is required to set criteria for treatment. This paper offers insight into the national act on baclofen and the experience at the Nottingham University Hospital...
- A clinical study of intrathecal baclofen using a programmable pump for intractable spasticityDaniel Guillaume
Centre Neurologique et de Réadaptation Fonctionnelle, Fraiture en Condroz, Belgium
Arch Phys Med Rehabil 86:2165-71. 2005..To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity...
- Baclofen toxicity in an 8-year-old with an intrathecal baclofen pumpRonald N Yeh
Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Emerg Med 26:163-7. 2004..This report describes the clinical presentation, unfamiliar dilemmas, and the management of a pediatric patient with intrathecal baclofen toxicity, noting problems that may arise in the care of these patients...
- Pharmacologic interventions for reducing spasticity in cerebral palsyDilip R Patel
Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
Indian J Pediatr 72:869-72. 2005....
- Long-term intrathecal baclofen therapy in ambulatory patients with spasticitySaud A Sadiq
MS Research and Treatment Center of New York, Albert Einstein College of Medicine, 425 West 59th Street, Suite 7C, New York, NY 10019, USA
J Neurol 253:563-9. 2006..This retrospective study is designed to determine the long-term ambulatory function in patients receiving ITB...
- Epilepsy and intrathecal baclofen therapy in children with cerebral palsyVincenzo Buonaguro
Department of Paediatric Orthopedics, Children s Hospital V Buzzi, Milan, Italy
Pediatr Neurol 33:110-3. 2005..We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity...
- Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary studyGerard E Francisco
Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas Houston Medical School, Houston, TX, USA
Arch Phys Med Rehabil 84:1194-9. 2003..To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors...
- Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literatureB M Soni
Regional Spinal Injuries Centre, Southport and Ormskirk NHS Trust, Southport, UK
Spinal Cord 41:586-9. 2003..Case report...
- [Intrathecal baclofen in severe spasticity due to multiple sclerosis]Jarosław Sławek
Kliniki Neurochirurgii Akademii Medycznej w Gdańsku
Neurol Neurochir Pol 37:1135-42; discussion 1143. 2003..At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted...
- Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patientsR Plassat
Department of Physical Medicine and Rehabilitation, CHU Angers, France
Spinal Cord 42:686-93. 2004..Case series of a consecutive sample. Retrospective audit...
- Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump functionMartin O'Connell
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Nucl Med 29:578-80. 2004
- Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal originA Zahavi
Department of Rehabilitation, University Groningen, Netherlands
J Neurol Neurosurg Psychiatry 75:1553-7. 2004..To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen...
- Salvage of baclofen pump pocket infection with muscle flapBishara S Atiyeh
Plast Reconstr Surg 114:1661-3. 2004
- [Intrathecal baclofen for treatment of spasticity in patient with cerebral palsy--a preliminary report]Marek Jozwiak
Klinika Ortopedii Dzieciecej, Akademia Medyczna im Karola Marcinkowskiego w Poznaniu
Chir Narzadow Ruchu Ortop Pol 68:253-9. 2003..Early results of spasticity treatment in cerebral palsy with intrathecal baclofen infusions are very promising...
- Implantable baclofen pump as an adjuvant in treatment of pressure soresSarah A Mess
Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA
Ann Plast Surg 51:465-7. 2003..Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients...
- Dosage of intrathecal baclofen maintenance therapy in the spastic syndromesYoussef Fares
Neurosurgical Service, Ntra Sra Clinic of the Conception Jimenez Diaz Foundation, Madrid, Spain
J Med Liban 52:13-8. 2004..81 microg/day in the final phase. These doses were higher in patients with medullary traumatic lesion, diffuse cerebral lesion and spastic idiopathic paraparesis. Relatively mild side effects were produced by the therapeutic doses used...
- Placement of baclofen pumps through the foramen magnum and upper cervical spineKristine Dziurzynski
Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Childs Nerv Syst 22:270-3. 2006..As an alternative to placing the pump catheter through the lumbar spine, we report our experience with placement of the catheter in the spinal canal via a cervical approach through the foramen magnum...
- Quality of life of patients with telemetric pumps for intrathecal baclofen infusion: data and limitations of assessment scalesPlacido Bramanti
Centro Studi Neurolesi, University of Messina, Italy
Funct Neurol 19:227-31. 2004..These results encourage us to continue this study in a larger patient sample, considering different types of pathology and presence/absence of caregivers...
- [Treatment of severe spacticity in multiple sclerosis by continuous intrathecal baclofen]Predrag Peric
Vojnomedicinska akademija, Klinika za neurohirurgiju, Beograd, Srbija i Crna Gora
Vojnosanit Pregl 63:187-91. 2006..Continuous intrathecal administration of baclofen (ITB), using a subcutaneously implanted programmable infusion pump, is a minimally invasive, reversible method for the treatment of severe diffuse spasticity of the spinal origin...
- Best-practice surgical techniques for intrathecal baclofen therapyA Leland Albright
Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
J Neurosurg 104:233-9. 2006..Panel members advocate the aforementioned techniques to improve the efficacy of and decrease the morbidity associated with ITB therapy...
- Intrathecal baclofen for the treatment of spasticityI Dones
Department of Neurosurgery, Instituto Nazionale Neurologico C Besta, Via Celoria, Milano, Italy
Acta Neurochir Suppl 97:185-8. 2007..Currently, treatment of spasticity with ITB is the most effective way of reducing spasticity regardless of its cause...
- Surgical management of spasticity of cerebral origin in childrenS Sgouros
Department of Neurosurgery, Birmingham Children s Hospital, Birmingham, UK
Acta Neurochir Suppl 97:193-203. 2007..Current pumps have practical limitations but, in the next decade, it is anticipated that technological improvements will render the pumps more patient friendly...
- Opisthotonus and intrathecal treatment with baclofen (ITB) in childrenBerten Ceulemans
Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
Eur J Pediatr 167:641-5. 2008..This increase in weight might be due to a reduction in energy expenditure as a result of the decrease in spasticity. Intrathecal treatment with baclofen should be considered in every child with opisthotonus...
- Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain reliefShearwood McClelland
Department of Neurosurgery, University of Minnesota Medical School, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Muscle Nerve 37:396-8. 2008..Postoperative pain reduction was predicted by the degree of pain reduction following preoperative ITB test injection. These results support ITB as a treatment modality for pain associated with spasticity in ALS...
- Infusion of intrathecal baclofen for acute withdrawal. Technical noteBradley S Duhon
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
J Neurosurg 107:878-80. 2007..In both cases, the patients recovered to their neurological baseline level, and lasting consequences of serious withdrawal were avoided...
- Functional effects of spinal baclofenHermann Muller
Dpt Anesthesiology, Intensive Care and Pain Therapy, Kemperhof Hospital, Koblenz, Germany
Przegl Lek 64:1-2. 2007
- [Baclofen dose in a screening test and in a baclofen pump filling--is there any differences]Przemysław Grzegorzewski
Oddział Neurochirurgii, Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:8-12. 2007..In this study we compared a bolus intrathecal injection given in a screening test with doses uses for filling a baclofen pump. In selected group we observed increased Baclofen dose due to dose given in screening test...
- [Assessment of spasticity therapy with baclofen pump in children]Anna Swierczyńska
Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:15-7. 2007..The aim of this study was to assess of treatment of spasticity in children with baclofen pump, before and after pump implantation...
- [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]Alicja Fafara
Oddział Neurochirurgii Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:18-21. 2007..It results also in improvement of patients and their families quality of life. The aim of study was to assess the effects after baclofen pump implantation due to parents expectations...
- Combined treatment with BTX-A and ITB for spasticity: case reportChandler E Gill
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
Tenn Med 100:41-2, 44. 2007..Expanded investigations should be carried out to evaluate the efficacy of combined therapy in patients with mental retardation...
- A review of the complications of intrathecal baclofen in patients with cerebral palsyKat Kolaski
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
NeuroRehabilitation 22:383-95. 2007..However, until we have consistent, reliable reports of complications, it will not be possible to perform specific risk/benefit analyses. Recommendations for improving investigation in this important area are discussed...
- Intrathecal antispastic drug application with implantable pumps: results of a 10 year follow-up studyA Koulousakis
Department of Neurosurgery, Cologne University, Cologne, Germany
Acta Neurochir Suppl 97:181-4. 2007..Destructive procedures such as myelotomy are no longer performed in our department in order to treat spasticity...
- Intrathecal baclofen therapy in patients with severe spasticityG A Marra
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
Acta Neurochir Suppl 97:173-80. 2007..These treatments, do not resolve spasticity in about 33% of cases. In these severe cases, more invasive procedures such as muscle infiltrations with botulin toxin and intrathecal baclofen infusion can be used...
- The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive casesFrancesco Motta
Department of Paediatric Orthopaedics, V Buzzi Children s Hospital, Milan, Italy
J Neurosurg 107:32-5. 2007..The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants...
- Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticityDobrivoje S Stokic
Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA
Clin Neurophysiol 117:1283-9. 2006..To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia...
- Intrathecal baclofen therapy: ten steps toward best practiceBarbara Ridley
Alta Bates Summit Medical Center, Berkeley, CA, USA
J Neurosci Nurs 38:72-82. 2006....
- [Coma induced by an overdose of intrathecal baclofen]H Alonso-Navarro
Rev Neurol 43:63-4. 2006
- Intrathecal baclofen therapy in childrenA Leland Albright
Department of Neurosurgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
Neurosurg Focus 21:e3. 2006..Additional investigation is needed to determine the effects of ITB on other movement disorders such as athetosis and chorea...
- Intrathecal baclofen in the treatment of adult spasticityJoseph C Hsieh
Section of Neurosurgery, University of Chicago, Illinois 60637, USA
Neurosurg Focus 21:e5. 2006..In this paper the authors survey the use of oral and intrathecal baclofen therapy, detail the surgical process, and explain the risks and benefits of the procedure...
- Continuous intrathecal baclofen administration by a fully implantable electronic pump for severe spasticity treatment: our experienceA Guglielmino
Anesthesia and Intensive Care Unit, Polyclinic University Hospital of Catania, Catania, Italy
Minerva Anestesiol 72:807-20. 2006....
- Intrathecal baclofen for muscle spasticity and pain--two case reportsDhafir Al Khudhairi
Sultan Bin Abdelaziz Humanitarian Centre and Riyadh Armed Forces Hospital, Saudi Arabia
Middle East J Anesthesiol 18:971-6. 2006
- [Management of increase in spasticity in patients with intrathecal baclofen pumps]N Roche
Service de médecine physique et réadaptation, Hopital Raymond Poincare, APHP, Universite de Versailles Saint Quentin, 104, Boulevard Raymond Poincare, 92380 Garches, France
Ann Readapt Med Phys 50:93-9. 2007..Diagnosis of these complications can be difficult. A diagnostic tree would be a useful tool in cases of suspected malfunctioning of the intrathecal bacolfen infusion system and would standardise the diagnostic procedure...
- Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 casesK D Ethans
Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Spinal Cord 43:214-8. 2005..The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail...
- Interaction of ventriculoperitoneal shunt and baclofen pumpDaniel H Fulkerson
Pediatric Neurosurgery Service, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 1134, Indianapolis, IN 46202, USA
Childs Nerv Syst 23:733-8. 2007..The authors present three cases of children with shunted hydrocephalus and intrathecal delivery of baclofen via an implanted pump. Each case illustrates a potential interaction of these devices...
- Inflammatory mass of an intrathecal catheter in patients receiving baclofen as a sole agent: a report of two cases and a review of the identification and treatment of the complicationTimothy R Deer
The Center for Pain Relief, Charleston, West Virginia and Department of Anesthesiologoy, West Virginia University, Charleston, West Virginia 25301, USA
Pain Med 8:259-62. 2007..Intrathecal baclofen has been used to treat spasticity secondary to stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and other neurological disease...
- Intrathecal baclofen therapy in adults and guideline for clinical nursing careRozina Bhimani
Sister Kenny Rehabilitation Associates, Abbott Northwestern Hospital, Minneapolis, MN, USA
Rehabil Nurs 33:110-6. 2008..A fundamental understanding of the intrathecal baclofen pump allows nurses to provide cutting-edge technological and individualized care with compassion...
- Intrathecal baclofen withdrawal mimicking sepsisLouise W Kao
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Emerg Med 24:423-7. 2003..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
- Intrathecal baclofen therapy in children with cerebral palsyTed R Brown
Arch Phys Med Rehabil 84:624; author reply 624. 2003
- Intrathecal baclofen withdrawal: a case report and review of the literatureTord D Alden
Department of Neurosurgery, St Louis Children s Hospital, One Children s Place, Suite 4S20, Washington University School of Medicine, MO 63110, USA
Childs Nerv Syst 18:522-5. 2002..Withdrawal from oral baclofen has been well described. Intrathecal baclofen withdrawal has been less frequently reported. We present a case of withdrawal after intrathecal baclofen pump catheter failure...
- Cyproheptadine for intrathecal baclofen withdrawalJay M Meythaler
Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
Arch Phys Med Rehabil 84:638-42. 2003..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
- Subfascial implantation of intrathecal baclofen pumps in children: technical noteB H Kopell
Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
Neurosurgery 49:753-6; discussion 756-7. 2001..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
- Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: a descriptive pilot studyKristie F Bjornson
Children s Hospital and Regional Medical Center, Neurodevelopmental Clinic, Spasticity Management Clinic, Seattle, WA, USA
Arch Phys Med Rehabil 84:500-6. 2003..To describe the oral motor, communication, and nutritional status of children receiving intrathecal baclofen (ITB) therapy for spasticity of cerebral origin...
- Intrathecal baclofen for spasticity management in Rett syndromeVivek Kadyan
Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA
Am J Phys Med Rehabil 82:560-2. 2003..The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome...
- Intrathecal baclofen for spasticity caused by thrombotic strokeB L Gwartz
Pain Diagnosis and Treatment, Inc, Glendora, CA 91741-4205, USA
Am J Phys Med Rehabil 80:383-7. 2001..The patient achieved substantial functional gains as well as improved ease of care, quality of life, and cessation of narcotic use...
- Monitoring of creatinine kinase during weaning of intrathecal baclofen and with symptoms of early withdrawalSam C Colachis
Department of Physical Medicine and Rehabilitation and SCI Rehabilitation, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Am J Phys Med Rehabil 82:489-92. 2003....
- On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966B A McMillen
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC
J Neural Transm Gen Sect 89:11-25. 1992..Thus, the effects of these muscle relaxants on DA neurons are mediated by a mechanism other than strychnine-insensitive glycine or GABAb receptors...
- [Centrally acting muscle relaxants and traffic hazards]J G Bramness
Statens rettstoksikologiske institutt, Oslo
Tidsskr Nor Laegeforen 120:1966-9. 2000..In later years there has been a marked increase in the number of blood samples testing positive for carisoprodol or meprobamate (the major metabolite)...
- The epidural and intrathecal administration of somatotrophin-release inhibiting factor: native and synthetic analoguesD P Beltrutti
Servizio di Anestesia e Rianimazione, Centro del Dolore, Ospedale S Spirito, Via Vittorio Emanuele, 3, 12042 Bra, Italy
Curr Rev Pain 4:82-90. 2000..for spinal administration, that is, epidural or intrathecal, such as the new narcotics, alpha-2 agonists, central muscle relaxants, calcitonin, and local anesthetics...
- [Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine]C Boido Canu
Istituto di Scienze Farmaceutiche,
Farmaco Sci 43:819-37. 1988..Interesting levels of activity were exhibited in several cases...
- A survey of the practice of electroconvulsive therapy in AsiaWorrawat Chanpattana
Department of Psychiatry, Samitivej Srinakarin Hospital, Bangkok, Thailand
J ECT 26:5-10. 2010..To describe a comprehensive survey of the practice of electroconvulsive therapy (ECT) in Asia...
- Do we need a new muscle relaxant in paediatrics?Nishan Goudsouzian
Paediatr Anaesth 13:1-2. 2003
- GW280430AGoetz F Geldner
Anesthesiology 102:861; author reply 862-5. 2005
- Pharmacological properties of NK433, a new centrally acting muscle relaxantK Sakitama
Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co Ltd, Tokyo, Japan
Eur J Pharmacol 273:47-56. 1995..In i.v. experiments, the effects of NK433 on decerebrate rigidities were similar to those of eperisone-HCl and tolperisone-HCl, but in p.o. experiments, NK433 was at least 3 times as potent as eperisone-HCl and tolperisone-HCl...
- Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cellsYen Chin Liu
Department of Anesthesiology, Kaohsiung Veterans General Hospital, City, Kaohsiung, Taiwan
Brain Res 959:86-97. 2003..The stimulatory effects of chlorzoxazone on these channels may be responsible for the underlying mechanism of chlorzoxazone actions on neurons and neuroendocrine cells...
- CYP2E1 expression in human lymphocytes from various ethnic populationsJ L Raucy
Agouron Institute, University of New Mexico School of Medicine, USA
Alcohol Clin Exp Res 23:1868-74. 1999..We previously demonstrated that lymphocyte CYP2E1 expression reflects in vivo activity of the hepatic enzyme...
- [Baclofen-associated encephalopathy in a hemodialysis patient with hiccups]L F Quintana
Servicio de Nefrologia y Trasplante Renal, Hospital Clinic, Barcelona
Nefrologia 26:486-8. 2006..We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose...
- Outcome of non-invasive treatment modalities on back pain: an evidence-based reviewMaurits W van Tulder
Institute for Research in Extramural Medicine, EMGO, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Eur Spine J 15:S64-81. 2006..Also, many trials showed methodological weaknesses, effects are compared to placebo, no treatment or waiting list controls, and effect sizes are small. Future trials should meet current quality standards and have adequate sample size...
- Calcium-induced calcium release and calcium buffering in retinal horizontal cellsEduardo Solessio
Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City 84132, USA
Vis Neurosci 19:713-25. 2002....
- Regulation of ryanodine receptors by dopamine D1 receptors during methamphetamine-induced place conditioningKazuhiro Kurokawa
Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki, Japan
J Neurochem 115:1206-14. 2010..These findings indicate that up-regulation of RyRs is regulated through the activation of dopamine D(1) receptors in the METH-conditioning...
- Epidemiology of restless legs syndrome as diagnosed in UK primary careDavid A M C van de Vijver
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences UIPS, P O Box 80 082, 3508 TB Utrecht, The Netherlands
Sleep Med 5:435-40. 2004..There may also be poor awareness of the condition among primary care physicians (PCPs)...
- Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticityMarcus Pohl
Dept of Neurological Rehabilitation, Klinik Bavaria, An der Wolfsschlucht 1 2, 01731 Kreischa, Germany
J Neurol 250:1195-200. 2003..5 hours, with a maximal effect at 4 hours after intrathecal baclofen injection. Clinical scales used to determine the effect of BBT should thus be carried out during this period-ideally at 4 hours after baclofen injection...
- Quinine intoxications: a continuing problemS Taylor
Br J Clin Pharmacol 57:817; author reply 817. 2004
- [Case of oromandibular dystonia presenting with severe impairment of mouth-opening, and a marked effect by administration of baclofen]Masamichi Ikawa
Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
Rinsho Shinkeigaku 46:661-3. 2006..Her clinical symptoms and dystonic pattern on the surface electromyography improved markedly after the administration. Baclofen is an effective drug for treatment of oromandibular dystonia...
- Tics in Tourette syndrome: new treatment optionsY Awaad
Children s Hospital of Michigan, Movement Disorder Clinic, Wayne State University, School of Medicine, Detroit 48201, USA
J Child Neurol 14:316-9. 1999..It is worthwhile considering this treatment approach in patients with tics/Tourette's syndrome in order to reduce or avoid the side effects of other medications. Further studies, however, are required...
- Muscle relaxants for nonspecific low back pain: a systematic review within the framework of the cochrane collaborationMaurits W van Tulder
Institute for Research in Extramural Medicine, Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
Spine (Phila Pa 1976) 28:1978-92. 2003..A systematic review of randomized and/or double-blinded controlled trials...
- Complications of intrathecal baclofen pump therapy in pediatric patientsAndrzej Borowski
Department of Orthopedics, Alfred I duPont Hospital for Children, Nemours Children s Clinic, Wilmington, DE 19899, USA
J Pediatr Orthop 30:76-81. 2010..The aim of this study was to investigate and evaluate complications of intrathecal baclofen (ITB) pump implantation and maintenance in children with cerebral palsy...
- Intrathecal baclofen for the treatment of tetanusM Lurdes Santos
Infectious Diseases Service Intensive Care Unit, Hospital S João and School of Medicine, Porto, Portugal
Clin Infect Dis 38:321-8. 2004..Seven patients had colonization of the catheter, and 1 patient developed meningitis. All patients except one recovered. In our study, this means of treatment was efficacious and well tolerated...
- Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysisErica C McKenzie
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
Am J Vet Res 65:74-9. 2004..To determine the effect of oral administration of dantrolene sodium on serum creatine kinase (CK) activity after exercise in horses with recurrent exertional rhabdomyolysis (RER)...
- Molecular cloning and functional characterization of Shaw-related potassium channels of trout CNSF Panofen
Department of Animal Physiology, University of Osnabruck, Barbarastr 11 49069, Osnabruck, Germany
Brain Res Mol Brain Res 83:9-19. 2000..During brain development Traw1 mRNA was initially identified at stage 31 (shortly after hatching) while transcripts encoding Traw2 were detectable already at stage 28 (1 week before hatching)...
- [Diclofenac 75mg. and 30 mg. orfenadine (Neodolpasse) versus placebo and piroxicam in postoperative analgesia after arthroscopy]J Malek
Klinika anesteziologie a resuscitace 3 LF UK a FNKV, Praha
Acta Chir Orthop Traumatol Cech 71:80-3. 2004..We used a new agent (Neodolpasse) based on diclophenac and orphenadine, and compared its efficacy with piroxicam and placebo...
- Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic ratsD R Fischer
Department of Surgery, University of Cincinnati, Ohio, USA
Shock 15:200-7. 2001..The observations are important from a clinical standpoint because they suggest that the catabolic response in skeletal muscle during sepsis may be prevented by treatment with a calcium antagonist...
- Benchmark data on the utilization and acquisition costs of central nervous system and muscular skeletal drugs among veterans with combat-related injuriesDustin D French
James A Haley VAMC, VISN 8 Patient Safety Center of Inquiry, 13000 Bruce B Downs Boulevard 118M, Tampa, FL 33612, USA
Mil Med 173:626-8. 2008..Little is known about the utilization and costs of central nervous system (CNS) and musculoskeletal medications in veterans with blast injuries...
- [Trends in the agents used for euthanasia and the relationship with the number of notifications]M L Rurup
VU Medisch Centrum, Instituut voor Extramuraal Geneeskundig Onderzoek, afd Sociale Geneeskunde, Amsterdam
Ned Tijdschr Geneeskd 150:618-24. 2006..To provide insight into the relationship between the drugs used for euthanasia and its notification...
- Intrathecal baclofen in the treatment of painful, disabling spasms in Friedreich's ataxiaDjamel Ben Smail
Service de médecine physique et réhabilitation, Hôpital R Poincaré, 104 Boulevard R Poincaré, 92380 Garches, France
Mov Disord 20:758-9. 2005..To our knowledge, this is the first report of an intrathecal baclofen-delivering pump implantation in an FA patient...
- Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymesBalazs Dalmadi
Division of Pharmacology and Drug Safety Research, Gedeon Richter Ltd, Budapest, Hungary
Drug Metab Dispos 31:631-6. 2003..On the basis of metabolites formed and indirect evidences of inhibition studies, a considerable involvement of a microsomal reductase is assumed...
- Intrathecal baclofen for the treatment of spasticity of cerebral originJennifer Disabato
Department of Child Neurology, Children s Hospital, Denver, CO, USA
J Spec Pediatr Nurs 8:31-4. 2003..Close collaboration and communication regarding the child and his/her response to ITB is essential to providing safe and effective care for this challenging population of patients...
- Determination of methocarbamol in equine serum and urine by high-performance liquid chromatography with ultraviolet detection and atmospheric pressure ionization-mass spectrometric confirmationM R Koupai-Abyazani
Can Test Laboratories Ltd, Vancouver, British Columbia, Canada
J Anal Toxicol 21:301-5. 1997..The peak concentrations of the drug were detected 1-4 h (urine) and 10-60 min (serum) after administration to four horses. The method validation results and drug elimination profiles for both urine and serum are presented and discussed...
- Neuroleptic malignant syndrome associated with metoclopramide in a burn patientRyan Nachreiner
Richard M Fairbanks Burn Unit, Wishard Memorial Hospital, Indiana University, School of Medicine, Indianapolis, Indiana 46202 5124, USA
J Burn Care Res 27:237-41. 2006..It is important for burn unit personnel to be aware of this syndrome because the early institution of therapy can be life saving...
- SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURYMartin Marsala; Fiscal Year: 2001..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2010....
- Abused Inhalant Actions at GABA and Glutamate SynapsesM MacIver; Fiscal Year: 2008..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane andtrichloroethylene. ..
- Local Immunosuppression for Liver TransplantationReza Mehvar; Fiscal Year: 2008..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
- Agonist Activity at G Protein Coupled ReceptorsFRED EHLERT; Fiscal Year: 2008..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
- Discriminative Stimulus Effects of Alcohol in MiceWouter Koek; Fiscal Year: 2007..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
- Leupeptin in a Canine Model of Duchenne Muscular DystrophyMARTIN CHILDERS; Fiscal Year: 2006..Specific Aim #4b: Compare lean body muscle mass and calpain activity between leupeptin and placebo-treated GRMD dogs. ..
- Physical and Pharmacological Effects on Movement in SCITHOMAS HORNBY; Fiscal Year: 2006..As a consequence of these findings, a radical change in pharmacological management of motor incomplete SCI will be indicated. ..
- BRAIN GALANIN RECEPTORS AND EPILEPSYAndrey Mazarati; Fiscal Year: 2006..abstract_text> ..
- MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCHDavid Simpson; Fiscal Year: 2005..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2005....
- ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSESM MacIver; Fiscal Year: 2004..abstract_text> ..
- PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITSJohn Whyte; Fiscal Year: 2003..The factor structure will also be compared to that obtained from a control sample. ..
- MUSCLE RESPONSE TO STRESS IN CANINE MUSCULAR DYSTROPHYMARTIN CHILDERS; Fiscal Year: 2002..It is anticipated that findings will improve the understanding of how dystrophic muscle responds to physical stress resulting in improved treatment for patients with Duchenne muscular dystrophy. ..
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2010..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..