central muscle relaxants

Summary

Summary: A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)

Top Publications

  1. pmc Cooling methods used in the treatment of exertional heat illness
    J E Smith
    Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
    Br J Sports Med 39:503-7; discussion 507. 2005
  2. ncbi GMFM 1 year after continuous intrathecal baclofen infusion
    Linda E Krach
    Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
    Pediatr Rehabil 8:207-13. 2005
  3. ncbi Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in children
    A Leland Albright
    Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosurg 101:64-8. 2004
  4. ncbi Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen
    Jørgen Feldbaek Nielsen
    Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Clin Neurol Neurosurg 104:142-5. 2002
  5. ncbi Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia
    A S Burns
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spinal Cord 39:413-9. 2001
  6. ncbi Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 11:663-73. 2003
  7. pmc Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers
    P Szentesi
    Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, H-4012
    J Gen Physiol 118:355-75. 2001
  8. ncbi [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan
    Bioorg Med Chem Lett 12:3263-5. 2002
  9. ncbi Malignant hyperthermia
    M Denborough
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Lancet 352:1131-6. 1998
  10. ncbi Myofascial pain disorders: theory to therapy
    Anthony H Wheeler
    Pain and Orthopedic Neurology, Charlotte Spine Center, Charlotte, North Carolina 28207, USA
    Drugs 64:45-62. 2004

Detail Information

Publications172 found, 100 shown here

  1. pmc Cooling methods used in the treatment of exertional heat illness
    J E Smith
    Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
    Br J Sports Med 39:503-7; discussion 507. 2005
    ..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
  2. ncbi GMFM 1 year after continuous intrathecal baclofen infusion
    Linda E Krach
    Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
    Pediatr Rehabil 8:207-13. 2005
    ..05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved...
  3. ncbi Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in children
    A Leland Albright
    Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosurg 101:64-8. 2004
    ....
  4. ncbi Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen
    Jørgen Feldbaek Nielsen
    Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Clin Neurol Neurosurg 104:142-5. 2002
    ..Complications are often due to infection or catheter problems...
  5. ncbi Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia
    A S Burns
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spinal Cord 39:413-9. 2001
    ..CONCLUSIONS: Intrathecal baclofen is a safe and effective intervention for treating upper extremity hypertonia of spinal origin. In addition, the level of intrathecal catheter placement is felt to be of importance...
  6. ncbi Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 11:663-73. 2003
    ....
  7. pmc Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers
    P Szentesi
    Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, H-4012
    J Gen Physiol 118:355-75. 2001
    ..The channel displayed a constant open probability for as long as 30-50 min after the application of the drug. These data locate the binding site for dantrolene to be on the SR membrane, but be distinct from the purified RYR itself...
  8. ncbi [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle
    Takamitsu Hosoya
    Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan
    Bioorg Med Chem Lett 12:3263-5. 2002
    ....
  9. ncbi Malignant hyperthermia
    M Denborough
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Lancet 352:1131-6. 1998
    ..By far the most common is inherited as a mendelian dominant characteristic and at present mutations in the human RYR account for no more than 20% of susceptible families...
  10. ncbi Myofascial pain disorders: theory to therapy
    Anthony H Wheeler
    Pain and Orthopedic Neurology, Charlotte Spine Center, Charlotte, North Carolina 28207, USA
    Drugs 64:45-62. 2004
    ..Chronic myofascial pain is usually a product of both physical and psychosocial influences that complicate convalescence...
  11. pmc Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Moroyama machi, Saitama 350 0495, Japan
    Br J Pharmacol 134:729-36. 2001
    ..8. These results indicate that the difference in opening modes of the RyR-Ca(2+) release channel is recognized by certain Dan derivatives...
  12. pmc Managing an effective treatment for neuroleptic malignant syndrome
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Crit Care 11:R4. 2007
    ..The aim of this study was to prove the efficacy of different NMS treatment strategies, focusing on the efficacy of dantrolene...
  13. ncbi Effects of dantrolene on rat diaphragm muscle during postnatal maturation
    G Orliaguet
    Department of Anesthesiology, Centre Hospitalo-Universitaire Necker-Enfants Malades, Paris, France
    Anesthesiology 94:468-74. 2001
    ..Our study suggests that developmental changes in the pharmacologic response to dantrolene are more rapid than those of ryanodine...
  14. ncbi Placement of baclofen pumps through the foramen magnum and upper cervical spine
    Kristine Dziurzynski
    Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Childs Nerv Syst 22:270-3. 2006
    ..As an alternative to placing the pump catheter through the lumbar spine, we report our experience with placement of the catheter in the spinal canal via a cervical approach through the foramen magnum...
  15. ncbi Opisthotonus and intrathecal treatment with baclofen (ITB) in children
    Berten Ceulemans
    Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
    Eur J Pediatr 167:641-5. 2008
    ..This increase in weight might be due to a reduction in energy expenditure as a result of the decrease in spasticity. Intrathecal treatment with baclofen should be considered in every child with opisthotonus...
  16. ncbi Dosage of intrathecal baclofen maintenance therapy in the spastic syndromes
    Youssef Fares
    Neurosurgical Service, Ntra Sra Clinic of the Conception Jimenez Diaz Foundation, Madrid, Spain
    J Med Liban 52:13-8. 2004
    ..81 microg/day in the final phase. These doses were higher in patients with medullary traumatic lesion, diffuse cerebral lesion and spastic idiopathic paraparesis. Relatively mild side effects were produced by the therapeutic doses used...
  17. ncbi Epilepsy and intrathecal baclofen therapy in children with cerebral palsy
    Vincenzo Buonaguro
    Department of Paediatric Orthopedics, Children s Hospital V Buzzi, Milan, Italy
    Pediatr Neurol 33:110-3. 2005
    ..We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity...
  18. ncbi Intrathecal baclofen for the treatment of spasticity
    I Dones
    Department of Neurosurgery, Instituto Nazionale Neurologico C Besta, Via Celoria, Milano, Italy
    Acta Neurochir Suppl 97:185-8. 2007
    ..Currently, treatment of spasticity with ITB is the most effective way of reducing spasticity regardless of its cause...
  19. ncbi Functional effects of spinal baclofen
    Hermann Muller
    Dpt Anesthesiology, Intensive Care and Pain Therapy, Kemperhof Hospital, Koblenz, Germany
    Przegl Lek 64:1-2. 2007
  20. ncbi Surgical management of spasticity of cerebral origin in children
    S Sgouros
    Department of Neurosurgery, Birmingham Children s Hospital, Birmingham, UK
    Acta Neurochir Suppl 97:193-203. 2007
    ..Current pumps have practical limitations but, in the next decade, it is anticipated that technological improvements will render the pumps more patient friendly...
  21. ncbi Infusion of intrathecal baclofen for acute withdrawal. Technical note
    Bradley S Duhon
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Neurosurg 107:878-80. 2007
    ..In both cases, the patients recovered to their neurological baseline level, and lasting consequences of serious withdrawal were avoided...
  22. ncbi Quality of life of patients with telemetric pumps for intrathecal baclofen infusion: data and limitations of assessment scales
    Placido Bramanti
    Centro Studi Neurolesi, University of Messina, Italy
    Funct Neurol 19:227-31. 2004
    ..These results encourage us to continue this study in a larger patient sample, considering different types of pathology and presence/absence of caregivers...
  23. ncbi [Intrathecal baclofen in severe spasticity due to multiple sclerosis]
    Jarosław Sławek
    Kliniki Neurochirurgii Akademii Medycznej w Gdańsku
    Neurol Neurochir Pol 37:1135-42; discussion 1143. 2003
    ..At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted...
  24. ncbi Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 cases
    K D Ethans
    Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Spinal Cord 43:214-8. 2005
    ..The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail...
  25. ncbi Salvage of baclofen pump pocket infection with muscle flap
    Bishara S Atiyeh
    Plast Reconstr Surg 114:1661-3. 2004
  26. pmc Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin
    A Zahavi
    Department of Rehabilitation, University Groningen, Netherlands
    J Neurol Neurosurg Psychiatry 75:1553-7. 2004
    ..To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen...
  27. ncbi Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief
    Shearwood McClelland
    Department of Neurosurgery, University of Minnesota Medical School, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Muscle Nerve 37:396-8. 2008
    ..Postoperative pain reduction was predicted by the degree of pain reduction following preoperative ITB test injection. These results support ITB as a treatment modality for pain associated with spasticity in ALS...
  28. ncbi Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump function
    Martin O'Connell
    Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Nucl Med 29:578-80. 2004
  29. ncbi Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patients
    R Plassat
    Department of Physical Medicine and Rehabilitation, CHU Angers, France
    Spinal Cord 42:686-93. 2004
    ..Case series of a consecutive sample. Retrospective audit...
  30. ncbi Intrathecal baclofen in the management of spasticity due to cerebral palsy
    Michael Vloeberghs
    Queens Medical Centre, Nottingham, UK
    Pediatr Rehabil 8:172-9. 2005
    ..However, further research is required to set criteria for treatment. This paper offers insight into the national act on baclofen and the experience at the Nottingham University Hospital...
  31. ncbi Intrathecal baclofen in the treatment of adult spasticity
    Joseph C Hsieh
    Section of Neurosurgery, University of Chicago, Illinois 60637, USA
    Neurosurg Focus 21:e5. 2006
    ..In this paper the authors survey the use of oral and intrathecal baclofen therapy, detail the surgical process, and explain the risks and benefits of the procedure...
  32. ncbi Continuous intrathecal baclofen administration by a fully implantable electronic pump for severe spasticity treatment: our experience
    A Guglielmino
    Anesthesia and Intensive Care Unit, Polyclinic University Hospital of Catania, Catania, Italy
    Minerva Anestesiol 72:807-20. 2006
    ....
  33. ncbi [Coma induced by an overdose of intrathecal baclofen]
    H Alonso-Navarro
    Rev Neurol 43:63-4. 2006
  34. ncbi Intrathecal baclofen for muscle spasticity and pain--two case reports
    Dhafir Al Khudhairi
    Sultan Bin Abdelaziz Humanitarian Centre and Riyadh Armed Forces Hospital, Saudi Arabia
    Middle East J Anesthesiol 18:971-6. 2006
  35. ncbi [Management of increase in spasticity in patients with intrathecal baclofen pumps]
    N Roche
    Service de médecine physique et réadaptation, Hopital Raymond Poincare, APHP, Universite de Versailles Saint Quentin, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Ann Readapt Med Phys 50:93-9. 2007
    ..Diagnosis of these complications can be difficult. A diagnostic tree would be a useful tool in cases of suspected malfunctioning of the intrathecal bacolfen infusion system and would standardise the diagnostic procedure...
  36. ncbi Intrathecal baclofen therapy: ten steps toward best practice
    Barbara Ridley
    Alta Bates Summit Medical Center, Berkeley, CA, USA
    J Neurosci Nurs 38:72-82. 2006
    ....
  37. ncbi Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticity
    Dobrivoje S Stokic
    Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA
    Clin Neurophysiol 117:1283-9. 2006
    ..To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia...
  38. ncbi Best-practice surgical techniques for intrathecal baclofen therapy
    A Leland Albright
    Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
    J Neurosurg 104:233-9. 2006
    ..Panel members advocate the aforementioned techniques to improve the efficacy of and decrease the morbidity associated with ITB therapy...
  39. ncbi Interaction of ventriculoperitoneal shunt and baclofen pump
    Daniel H Fulkerson
    Pediatric Neurosurgery Service, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 1134, Indianapolis, IN 46202, USA
    Childs Nerv Syst 23:733-8. 2007
    ..The authors present three cases of children with shunted hydrocephalus and intrathecal delivery of baclofen via an implanted pump. Each case illustrates a potential interaction of these devices...
  40. ncbi Long-term intrathecal baclofen therapy in ambulatory patients with spasticity
    Saud A Sadiq
    MS Research and Treatment Center of New York, Albert Einstein College of Medicine, 425 West 59th Street, Suite 7C, New York, NY 10019, USA
    J Neurol 253:563-9. 2006
    ..This retrospective study is designed to determine the long-term ambulatory function in patients receiving ITB...
  41. ncbi Inflammatory mass of an intrathecal catheter in patients receiving baclofen as a sole agent: a report of two cases and a review of the identification and treatment of the complication
    Timothy R Deer
    The Center for Pain Relief, Charleston, West Virginia and Department of Anesthesiologoy, West Virginia University, Charleston, West Virginia 25301, USA
    Pain Med 8:259-62. 2007
    ..Intrathecal baclofen has been used to treat spasticity secondary to stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and other neurological disease...
  42. ncbi The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive cases
    Francesco Motta
    Department of Paediatric Orthopaedics, V Buzzi Children s Hospital, Milan, Italy
    J Neurosurg 107:32-5. 2007
    ..The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants...
  43. ncbi Pharmacologic interventions for reducing spasticity in cerebral palsy
    Dilip R Patel
    Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
    Indian J Pediatr 72:869-72. 2005
    ....
  44. ncbi A clinical study of intrathecal baclofen using a programmable pump for intractable spasticity
    Daniel Guillaume
    Centre Neurologique et de Réadaptation Fonctionnelle, Fraiture en Condroz, Belgium
    Arch Phys Med Rehabil 86:2165-71. 2005
    ..To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity...
  45. ncbi Intrathecal baclofen therapy in patients with severe spasticity
    G A Marra
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Acta Neurochir Suppl 97:173-80. 2007
    ..These treatments, do not resolve spasticity in about 33% of cases. In these severe cases, more invasive procedures such as muscle infiltrations with botulin toxin and intrathecal baclofen infusion can be used...
  46. ncbi Intrathecal antispastic drug application with implantable pumps: results of a 10 year follow-up study
    A Koulousakis
    Department of Neurosurgery, Cologne University, Cologne, Germany
    Acta Neurochir Suppl 97:181-4. 2007
    ..Destructive procedures such as myelotomy are no longer performed in our department in order to treat spasticity...
  47. ncbi Intrathecal baclofen therapy in children
    A Leland Albright
    Department of Neurosurgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
    Neurosurg Focus 21:e3. 2006
    ..Additional investigation is needed to determine the effects of ITB on other movement disorders such as athetosis and chorea...
  48. ncbi Baclofen toxicity in an 8-year-old with an intrathecal baclofen pump
    Ronald N Yeh
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Emerg Med 26:163-7. 2004
    ..This report describes the clinical presentation, unfamiliar dilemmas, and the management of a pediatric patient with intrathecal baclofen toxicity, noting problems that may arise in the care of these patients...
  49. ncbi [Treatment of severe spacticity in multiple sclerosis by continuous intrathecal baclofen]
    Predrag Peric
    Vojnomedicinska akademija, Klinika za neurohirurgiju, Beograd, Srbija i Crna Gora
    Vojnosanit Pregl 63:187-91. 2006
    ..Continuous intrathecal administration of baclofen (ITB), using a subcutaneously implanted programmable infusion pump, is a minimally invasive, reversible method for the treatment of severe diffuse spasticity of the spinal origin...
  50. ncbi Intrathecal baclofen for the treatment of spasticity of cerebral origin
    Jennifer Disabato
    Department of Child Neurology, Children s Hospital, Denver, CO, USA
    J Spec Pediatr Nurs 8:31-4. 2003
    ..Close collaboration and communication regarding the child and his/her response to ITB is essential to providing safe and effective care for this challenging population of patients...
  51. ncbi Intrathecal baclofen therapy in children with cerebral palsy
    Ted R Brown
    Arch Phys Med Rehabil 84:624; author reply 624. 2003
  52. ncbi Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: a descriptive pilot study
    Kristie F Bjornson
    Children s Hospital and Regional Medical Center, Neurodevelopmental Clinic, Spasticity Management Clinic, Seattle, WA, USA
    Arch Phys Med Rehabil 84:500-6. 2003
    ..To describe the oral motor, communication, and nutritional status of children receiving intrathecal baclofen (ITB) therapy for spasticity of cerebral origin...
  53. ncbi Combined treatment with BTX-A and ITB for spasticity: case report
    Chandler E Gill
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
    Tenn Med 100:41-2, 44. 2007
    ..Expanded investigations should be carried out to evaluate the efficacy of combined therapy in patients with mental retardation...
  54. ncbi A review of the complications of intrathecal baclofen in patients with cerebral palsy
    Kat Kolaski
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    NeuroRehabilitation 22:383-95. 2007
    ..However, until we have consistent, reliable reports of complications, it will not be possible to perform specific risk/benefit analyses. Recommendations for improving investigation in this important area are discussed...
  55. ncbi Intrathecal baclofen withdrawal: a case report and review of the literature
    Tord D Alden
    Department of Neurosurgery, St Louis Children s Hospital, One Children s Place, Suite 4S20, Washington University School of Medicine, MO 63110, USA
    Childs Nerv Syst 18:522-5. 2002
    ..Withdrawal from oral baclofen has been well described. Intrathecal baclofen withdrawal has been less frequently reported. We present a case of withdrawal after intrathecal baclofen pump catheter failure...
  56. ncbi Intrathecal baclofen therapy in adults and guideline for clinical nursing care
    Rozina Bhimani
    Sister Kenny Rehabilitation Associates, Abbott Northwestern Hospital, Minneapolis, MN, USA
    Rehabil Nurs 33:110-6. 2008
    ..A fundamental understanding of the intrathecal baclofen pump allows nurses to provide cutting-edge technological and individualized care with compassion...
  57. ncbi Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticity
    Marcus Pohl
    Dept of Neurological Rehabilitation, Klinik Bavaria, An der Wolfsschlucht 1 2, 01731 Kreischa, Germany
    J Neurol 250:1195-200. 2003
    ..5 hours, with a maximal effect at 4 hours after intrathecal baclofen injection. Clinical scales used to determine the effect of BBT should thus be carried out during this period-ideally at 4 hours after baclofen injection...
  58. ncbi Subfascial implantation of intrathecal baclofen pumps in children: technical note
    B H Kopell
    Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 49:753-6; discussion 756-7. 2001
    ..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
  59. ncbi Intrathecal baclofen for spasticity caused by thrombotic stroke
    B L Gwartz
    Pain Diagnosis and Treatment, Inc, Glendora, CA 91741-4205, USA
    Am J Phys Med Rehabil 80:383-7. 2001
    ..The patient achieved substantial functional gains as well as improved ease of care, quality of life, and cessation of narcotic use...
  60. ncbi Cyproheptadine for intrathecal baclofen withdrawal
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
    Arch Phys Med Rehabil 84:638-42. 2003
    ..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
  61. ncbi Intrathecal baclofen withdrawal mimicking sepsis
    Louise W Kao
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Emerg Med 24:423-7. 2003
    ..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
  62. ncbi [Intrathecal baclofen for treatment of spasticity in patient with cerebral palsy--a preliminary report]
    Marek Jozwiak
    Klinika Ortopedii Dzieciecej, Akademia Medyczna im Karola Marcinkowskiego w Poznaniu
    Chir Narzadow Ruchu Ortop Pol 68:253-9. 2003
    ..Early results of spasticity treatment in cerebral palsy with intrathecal baclofen infusions are very promising...
  63. ncbi [Baclofen dose in a screening test and in a baclofen pump filling--is there any differences]
    Przemysław Grzegorzewski
    Oddział Neurochirurgii, Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:8-12. 2007
    ..In this study we compared a bolus intrathecal injection given in a screening test with doses uses for filling a baclofen pump. In selected group we observed increased Baclofen dose due to dose given in screening test...
  64. ncbi Implantable baclofen pump as an adjuvant in treatment of pressure sores
    Sarah A Mess
    Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA
    Ann Plast Surg 51:465-7. 2003
    ..Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients...
  65. ncbi Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literature
    B M Soni
    Regional Spinal Injuries Centre, Southport and Ormskirk NHS Trust, Southport, UK
    Spinal Cord 41:586-9. 2003
    ..Case report...
  66. ncbi Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study
    Gerard E Francisco
    Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas Houston Medical School, Houston, TX, USA
    Arch Phys Med Rehabil 84:1194-9. 2003
    ..To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors...
  67. ncbi [Assessment of spasticity therapy with baclofen pump in children]
    Anna Swierczyńska
    Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:15-7. 2007
    ..The aim of this study was to assess of treatment of spasticity in children with baclofen pump, before and after pump implantation...
  68. ncbi Monitoring of creatinine kinase during weaning of intrathecal baclofen and with symptoms of early withdrawal
    Sam C Colachis
    Department of Physical Medicine and Rehabilitation and SCI Rehabilitation, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Phys Med Rehabil 82:489-92. 2003
    ....
  69. ncbi [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]
    Alicja Fafara
    Oddział Neurochirurgii Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:18-21. 2007
    ..It results also in improvement of patients and their families quality of life. The aim of study was to assess the effects after baclofen pump implantation due to parents expectations...
  70. ncbi Intrathecal baclofen for spasticity management in Rett syndrome
    Vivek Kadyan
    Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA
    Am J Phys Med Rehabil 82:560-2. 2003
    ..The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome...
  71. ncbi On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966
    B A McMillen
    Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC
    J Neural Transm Gen Sect 89:11-25. 1992
    ..Thus, the effects of these muscle relaxants on DA neurons are mediated by a mechanism other than strychnine-insensitive glycine or GABAb receptors...
  72. ncbi [Centrally acting muscle relaxants and traffic hazards]
    J G Bramness
    Statens rettstoksikologiske institutt, Oslo
    Tidsskr Nor Laegeforen 120:1966-9. 2000
    ..In later years there has been a marked increase in the number of blood samples testing positive for carisoprodol or meprobamate (the major metabolite)...
  73. ncbi The epidural and intrathecal administration of somatotrophin-release inhibiting factor: native and synthetic analogues
    D P Beltrutti
    Servizio di Anestesia e Rianimazione, Centro del Dolore, Ospedale S Spirito, Via Vittorio Emanuele, 3, 12042 Bra, Italy
    Curr Rev Pain 4:82-90. 2000
    ..for spinal administration, that is, epidural or intrathecal, such as the new narcotics, alpha-2 agonists, central muscle relaxants, calcitonin, and local anesthetics...
  74. ncbi An initially unsuspected case of baclofen overdose
    Geoffrey C Wall
    Iowa Methodist Medical Center, Des Moines, IA, USA
    Am J Crit Care 15:611-3. 2006
  75. ncbi Carisoprodol, meprobamate, and driving impairment
    B K Logan
    Washington State Toxicology Laboratory, Washington State Patrol, Seattle 98134, USA
    J Forensic Sci 45:619-23. 2000
    ....
  76. ncbi Effects of intramuscular acepromazine and diazepam on tear production in rabbits
    M Selk Ghaffari
    Department of Clinical Studies, Islamic Azad University, Karaj, Iran
    Vet Rec 164:147-8. 2009
    ..The Schirmer tests were repeated after 15 and 25 minutes. There was a significant reduction in tear production by the rabbits treated with acepromazine, but no significant change in tear production by the rabbits treated with diazepam...
  77. doi Persistent heartburn in a patient on proton-pump inhibitor
    Ronnie Fass
    The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona 85723 0001, USA
    Clin Gastroenterol Hepatol 6:393-400. 2008
  78. doi A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene
    P Jason Toppin
    Department of Anesthesia and Pain Management, Toronto General Hospital, University of Toronto, ON, Canada
    Can J Anaesth 57:689-93. 2010
    ..To report the identification of a novel mutation in the CACNA1S gene that encodes the alpha-1-subunit (Cav1.1) of the voltage-gated skeletal muscle L-type calcium channel in a patient with malignant hyperthermia...
  79. ncbi Comparison between effects of dantrolene and nifedipine on lipopolysaccharide-induced endotoxemia in the anesthetized rats
    C C Wu
    Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, ROC
    Chin J Physiol 42:211-7. 1999
    ..Thus, both dantrolene and nifedipine have beneficial hemodynamic effects, although through different mechanisms, in animals with endotoxic shock...
  80. doi Cardiac surgery in the parturient
    Shobana Chandrasekhar
    Baylor College of Medicine Division of Cardiovascular Anesthesiology at the TX Heart Institute, St Luke s Episcopal Hospital, 6720 Bertner Ave, Houston, TX 77030, USA
    Anesth Analg 108:777-85. 2009
    ..5 L x min(-1) x m(-2) and perfusion pressure >70 mm Hg; 2) maintaining the hematocrit > 28%; 3) using normothermic perfusion when feasible; 4) using pulsatile flow; and 5) using alpha-stat pH management...
  81. doi Neuroleptic malignant syndrome from central nervous system insult: 4 cases and a novel treatment strategy. Clinical article
    Scott D Wait
    Divisions of Neurological Surgery, Barrow Neurological Institue, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosurg Pediatr 4:217-21. 2009
    ..Alleviation of any CNS insult is the first order of treatment. Some patients with persistent symptoms of NMS may benefit from intrathecal delivery of baclofen...
  82. ncbi Stability-indicating HPLC method for the determination of impurities in meprobamate with refractive index detection
    K Karthikeyan
    Analytical Development, Shasun Research Center, Chennai 600048, India
    J Chromatogr Sci 48:212-8. 2010
    ..1%. Good linearity (r(2) > 0.99) and precision (RSD < 2.2%) have been obtained for MEP, MP0, and MP1. This method has been applied successfully to determine the content of impurities in MEP bulk drug...
  83. doi Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder
    Soon Chul Myung
    Research Institute for Translational System Biomics, Chung Ang University, College of Medicine, Seoul, South Korea
    J Sex Med 5:1088-96. 2008
    ..Aims. However, there has been no basic research to clarify the relationship between OAB and female sexual dysfunction. Therefore, we investigated this issue using a rabbit model of OAB...
  84. ncbi Carisoprodol intoxications: a retrospective study of forensic autopsy material from 1992-2003
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, P O Box 4404, Nydalen, 0403 Oslo, Norway
    Int J Legal Med 121:403-9. 2007
    ..There were, however, only a small number of cases where the cause of death can be attributed to use of carisoprodol alone...
  85. ncbi [Efficacy of intrathecal baclofen in the treatment of spasticity in stroke]
    D Lamotte
    Service de Medecine Physique et de Readaptation, hôpital Reine Hortense, boulevard Berthollet, 73100 Aix les Bains, France
    Ann Readapt Med Phys 50:165-9. 2007
    ..To determine whether intrathecal administration of baclofen reduced spastic hypertonia in a hemiplegic patient after hemorrhagic stroke...
  86. ncbi Management and rehabilitation of neuropathic bladder in patients with spinal cord lesion
    C A Rapidi
    Neuropathic Bladder Unit, Rehabilitation Department, National Rehabilitation Center, Athens, Greece
    Acta Neurochir Suppl 97:307-14. 2007
    ..All efforts should be directed towards the functional integrity of the upper urinary tract and the acquirement of the greatest possible independence for the patient...
  87. ncbi Blockers of monoamine transporters influence high dopamine concentration uptake in rat brain slices
    M Yu Iniouchine
    Department Physiology, School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    Dokl Biol Sci 419:80-2. 2008
  88. ncbi [Use of local injections of tolperisone (midocalm) in combination with tractional therapy in the treatment of vertebral static syndrome]
    Ia Iu Zakharov
    Zh Nevrol Psikhiatr Im S S Korsakova 107:30-4. 2007
    ..A quantitative assessment revealed that in the indexed group treatment efficacy was 1,56 times higher and the effect achieved sooner than in the comparison group...
  89. pmc Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia
    Dawei Jiang
    Libin Cardiovascular Institutes of Alberta, Department of Physiology, University of Calgary, Calgary, Alberta, Canada
    J Biol Chem 283:20813-20. 2008
    ..Together, our data support a view in which altered luminal Ca(2+) regulation of RyR1 represents a primary causal mechanism of MH...
  90. doi Recurrent transient global amnesia with intrathecal baclofen
    Lucinda A Grande
    Department of Anesthesiology, Box 356540, University of Washington School of Medicine, Seattle, WA 98195, USA
    Anesth Analg 106:1284-7, table of contents. 2008
    ..Baclofen-induced amnesia in rodents is a reliable model of memory impairment. In contrast, baclofen-induced memory impairment in humans is uncommon. Baclofen- associated transient global amnesia has not previously been reported...
  91. doi Incidence and identification of intrathecal baclofen catheter malfunction
    Eric M Dvorak
    Department of Physical Medicine and Rehabilitation, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    PM R 2:751-6. 2010
    ..An internal review was performed to develop a diagnostic flow chart to have a systematic method for identifying ITB pump and catheter complications...
  92. ncbi Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    P J Medina
    Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy and Hematology Oncology Section, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73190, USA
    Curr Opin Hematol 8:286-93. 2001
    ..Recognition of a drug-associated etiology in a patient with TTP-HUS is critical to avoid re-exposure and recurrent illness...
  93. ncbi Atypical neuroleptic malignant syndrome caused by clozapine and venlafaxine: early brief treatment with dantrolene
    Vittorio Ferioli
    Can J Psychiatry 49:497-8. 2004
  94. ncbi Clinical inquiries. Does quinine reduce leg cramps for young athletes?
    Noelle Robertson
    Moses Cone Health System, Greensboro, NC, USA
    J Fam Pract 54:76-8. 2005
  95. ncbi [Placental passage of anesthetics and adjuvants]
    C Lang
    Klinik für Anästhesie und Intensivtherapie, Klinikum, Philipps Universitat Marburg, Baldingerstrasse, 35033 Marburg
    Anaesthesist 51:409-17. 2002
    ....
  96. ncbi Bifid condyle: case report
    Guadalupe Corchero-Martín
    Med Oral Patol Oral Cir Bucal 10:277-9. 2005
    ..Treatment is conservative for symptomatic patients with TMJ disorders, surgical treatment is described in literature in TMJ ankylosis that develops in bifid condyles secondary to trauma...
  97. ncbi GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats
    Carla Lobina
    Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Brain Res Brain Res Protoc 15:1-5. 2005
    ....
  98. ncbi Exacerbating factors in neuroleptic malignant syndrome: comparisons between cases with death, sequelae, and full recovery
    Masanori Nagamine
    J Clin Psychopharmacol 25:499-501. 2005
  99. pmc Volume of the effect compartment in simulations of neuromuscular block
    Vladimir Nigrovic
    Department of Anesthesiology, Medical University of Ohio, Toledo, OH, USA
    Theor Biol Med Model 2:41. 2005
    ..The study examines the role of the volume of the effect compartment in simulations of neuromuscular block (NMB) produced by nondepolarizing muscle relaxants...
  100. ncbi Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in rats
    S R R Hall
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Am J Transplant 5:2862-9. 2005
    ..Dantrolene without mannitol was without effect. Since mannitol exhibits free radical scavenging properties, protection could be the result of a decrease in oxidative stress after intra-cranial hypertension...
  101. ncbi Transverse myelitis associated with restless legs syndrome and periodic movements of sleep responsive to an oral dopaminergic agent but not to intrathecal baclofen
    L K Brown
    The University of Arizona College of Medicine, Tucson, AZ, USA
    Sleep 23:591-4. 2000
    ..All symptoms of RLS/PLMD resolved after treatment with pergolide...

Research Grants72

  1. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2010
    ..Advancement of knowledge in this area will likely contribute to the development of effective therapy and the improvement of quality of life in those patients who suffer from both epilepsy and depression. ..
  2. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. ..
  3. Thymectomy in Non-Thymomatous MG Patients on Prednisone
    Camilla Buckley; Fiscal Year: 2007
    ..Subgroup analysis may show whether benefits are confined to those who are prednisone naive at entry or in a particular age group. Thus the results will impact on current clinical practice. ..
  4. Rehabilitation Medicine Scientist Training (RMST) Program
    John Whyte; Fiscal Year: 2007
    ..The net result of the program will be a cadre of faculty for departments of PM&R who can compete successfully for extramural funds and be productive independent investigators, ultimately fulfilling a vision of physiatric research. ..
  5. Research Methods for Cognitive Rehabilitation
    John Whyte; Fiscal Year: 2007
    ..Importantly, a subject recruitment infrastructure within the Core will make it feasible for visiting or remote collaborators to identify appropriate subjects for study during brief research visits. ..
  6. Leupeptin in a Canine Model of Duchenne Muscular Dystrophy
    MARTIN CHILDERS; Fiscal Year: 2006
    ..Specific Aim #4b: Compare lean body muscle mass and calpain activity between leupeptin and placebo-treated GRMD dogs. ..
  7. Abused Inhalant Actions at GABA and Glutamate Synapses
    M MacIver; Fiscal Year: 2007
    ..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane and trichloroethylene. ..
  8. Local Immunosuppression for Liver Transplantation
    Reza Mehvar; Fiscal Year: 2007
    ..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
  9. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2007
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  10. Agonist Activity at G Protein Coupled Receptors
    FRED EHLERT; Fiscal Year: 2007
    ..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
  11. Physical and Pharmacological Effects on Movement in SCI
    THOMAS HORNBY; Fiscal Year: 2006
    ..As a consequence of these findings, a radical change in pharmacological management of motor incomplete SCI will be indicated. ..
  12. CRCNS: Spatial & Temporal Aspects of cAMP/PKA Signaling Underlying Information
    KIM L contact BLACKWELL; Fiscal Year: 2010
    ..Successful completion of the research will form the basis for investigating how alterations in this pathway contributes to psychiatric disease such as schizophrenia and alcoholism. ..
  13. Vulnerability to Opioids: A Mouse Model
    Wouter Koek; Fiscal Year: 2010
    ....
  14. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ....
  15. CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger Pathways
    KIM BLACKWELL; Fiscal Year: 2009
    ..Thus, the results of this research may help in the development of treatments for alcohol addiction. ..
  16. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  17. AIRWAY PROTECTION DURING VOMITING
    Ivan Lang; Fiscal Year: 2002
    ..Finally, the relative contribution of peripheral reflexes and direct central nervous system control over the motor events that comprise vomiting will be studied. ..
  18. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2003
    ....
  19. MUSCLE RESPONSE TO STRESS IN CANINE MUSCULAR DYSTROPHY
    MARTIN CHILDERS; Fiscal Year: 2002
    ..It is anticipated that findings will improve the understanding of how dystrophic muscle responds to physical stress resulting in improved treatment for patients with Duchenne muscular dystrophy. ..
  20. SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURY
    Martin Marsala; Fiscal Year: 2001
    ..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
  21. ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSES
    M MacIver; Fiscal Year: 2000
    ..Parallel studies will determine the extent to which an anesthetic-induced depression of CA 1 neuron discharge can be reversed by blocking GABA receptor/Cl- channels. ..
  22. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2005
    ..By identifying the role of specific receptors in abuse-related effects of GHB, future studies may be better able to develop specific, pharmacologically targeted therapies for GHB abuse. ..
  23. MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCH
    David Simpson; Fiscal Year: 2005
    ..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..
  24. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....
  25. ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSES
    M MacIver; Fiscal Year: 2004
    ..abstract_text> ..
  26. PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITS
    John Whyte; Fiscal Year: 2003
    ..The factor structure will also be compared to that obtained from a control sample. ..
  27. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..