histamine h2 antagonists

Summary

Summary: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.

Top Publications

  1. ncbi Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    JAMA 292:1955-60. 2004
  2. pmc Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: a population-based case-control study
    Sascha Dublin
    Group Health Research Institute, Seattle, Washington 98101 1448, USA
    Pharmacoepidemiol Drug Saf 19:792-802. 2010
  3. ncbi Proton-pump inhibitor use and the risk for community-acquired pneumonia
    Monika Sarkar
    University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Ann Intern Med 149:391-8. 2008
  4. ncbi Differential risk of Clostridium difficile infection with proton pump inhibitor use by level of antibiotic exposure
    Vanessa Stevens
    Center For Health Outcomes, Pharmacoinformatics, and Epidemiology, SUNY Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA
    Pharmacoepidemiol Drug Saf 20:1035-42. 2011
  5. ncbi Role of gastroesophageal reflux symptoms in exacerbations of COPD
    Ivan E Rascon-Aguilar
    University of Florida Health Science Center Jacksonville, Division of Gastroenterology, 4555 Emerson Expressway, Suite 300, Jacksonville, FL 32207, USA
    Chest 130:1096-101. 2006
  6. ncbi The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
    C Privou
    Institute of Physiological Psychology I and Center for Biological and Medical Research, University of Dusseldorf, Germany
    Neuropharmacology 37:1019-32. 1998
  7. ncbi Risk of community-acquired pneumonia and the use of statins, ace inhibitors and gastric acid suppressants: a population-based case-control study
    Puja R Myles
    Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Pharmacoepidemiol Drug Saf 18:269-75. 2009
  8. pmc Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies
    Sandra Dial
    Department of Critical Care, Montreal Chest Institute, QC
    CMAJ 171:33-8. 2004
  9. ncbi Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection
    Michael D Howell
    Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Arch Intern Med 170:784-90. 2010
  10. ncbi Systematic review of the risk of enteric infection in patients taking acid suppression
    Jennifer Leonard
    Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 102:2047-56; quiz 2057. 2007

Research Grants

Detail Information

Publications228 found, 100 shown here

  1. ncbi Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    JAMA 292:1955-60. 2004
    ..Reduction of gastric acid secretion by acid-suppressive therapy allows pathogen colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated stomach have been identified as species from the oral cavity...
  2. pmc Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: a population-based case-control study
    Sascha Dublin
    Group Health Research Institute, Seattle, Washington 98101 1448, USA
    Pharmacoepidemiol Drug Saf 19:792-802. 2010
    ..To examine whether use of proton pump inhibitors (PPIs) and H2 blockers is associated with increased pneumonia risk...
  3. ncbi Proton-pump inhibitor use and the risk for community-acquired pneumonia
    Monika Sarkar
    University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Ann Intern Med 149:391-8. 2008
    ..Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP)...
  4. ncbi Differential risk of Clostridium difficile infection with proton pump inhibitor use by level of antibiotic exposure
    Vanessa Stevens
    Center For Health Outcomes, Pharmacoinformatics, and Epidemiology, SUNY Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA
    Pharmacoepidemiol Drug Saf 20:1035-42. 2011
    ....
  5. ncbi Role of gastroesophageal reflux symptoms in exacerbations of COPD
    Ivan E Rascon-Aguilar
    University of Florida Health Science Center Jacksonville, Division of Gastroenterology, 4555 Emerson Expressway, Suite 300, Jacksonville, FL 32207, USA
    Chest 130:1096-101. 2006
    ..The aims of this investigation were to determine the prevalence of gastroesophageal reflux (GER) symptoms in COPD patients and the effect of GER on the rate of exacerbations of COPD per year...
  6. ncbi The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
    C Privou
    Institute of Physiological Psychology I and Center for Biological and Medical Research, University of Dusseldorf, Germany
    Neuropharmacology 37:1019-32. 1998
    ....
  7. ncbi Risk of community-acquired pneumonia and the use of statins, ace inhibitors and gastric acid suppressants: a population-based case-control study
    Puja R Myles
    Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Pharmacoepidemiol Drug Saf 18:269-75. 2009
    ..The evidence is conflicting however. Our aim was to investigate the effect of these drugs on pneumonia using population-based data from the UK...
  8. pmc Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies
    Sandra Dial
    Department of Critical Care, Montreal Chest Institute, QC
    CMAJ 171:33-8. 2004
    ..Reduced gastric acidity has been suggested as a risk factor, and we hypothesized that proton pump inhibitors, because of their potency, may be an independent risk factor for this problem...
  9. ncbi Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection
    Michael D Howell
    Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Arch Intern Med 170:784-90. 2010
    ..The incidence and severity of Clostridium difficile infections are increasing. Acid-suppressive therapy has been suggested as a risk factor for C difficile, but this remains controversial...
  10. ncbi Systematic review of the risk of enteric infection in patients taking acid suppression
    Jennifer Leonard
    Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 102:2047-56; quiz 2057. 2007
    ..There have been concerns raised about the possible association of PPIs with enteric infections...
  11. ncbi Long-term proton pump inhibitor therapy and risk of hip fracture
    Yu Xiao Yang
    Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    JAMA 296:2947-53. 2006
    ..Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps...
  12. ncbi Acid-suppressive medication use and the risk for hospital-acquired pneumonia
    Shoshana J Herzig
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    JAMA 301:2120-8. 2009
    ..The use of acid-suppressive medication has been steadily increasing, particularly in the inpatient setting, despite lack of an accepted indication in the majority of these patients...
  13. ncbi Gastroprotective drugs in Australia: utilization patterns between 1997 and 2006 in relation to NSAID prescribing
    Nadia Barozzi
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Clin Ther 31:849-61. 2009
    ..PPI prescribing increased in Australia between 1997 and 2006, and some authorities are concerned that this increase may be due to prescriptions outside the approved indications...
  14. ncbi Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis
    Chun Shing Kwok
    Norwich Medical School, University of East Anglia, Norwich, UK
    Am J Gastroenterol 107:1011-9. 2012
    ..We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs)...
  15. ncbi Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism
    Weber C da Silva
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Neurobiol Learn Mem 86:100-6. 2006
    ....
  16. ncbi Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis
    Waleed Alhazzani
    Department of Medicine, McMaster University, Hamilton, Canada
    Crit Care Med 41:693-705. 2013
    ..Acid suppression is commonly prescribed for patients at risk of stress ulcer bleeding. Whether proton pump inhibitors are more effective than histamine 2 receptor antagonists is unclear...
  17. ncbi Clostridium difficile infection in an urban medical center: five-year analysis of infection rates among adult admissions and association with the use of proton pump inhibitors
    Suresh Jayatilaka
    Division of Gastroenterology, School of Graduate Medical Education, Seton Hall University, South Orange, NY, USA
    Ann Clin Lab Sci 37:241-7. 2007
    ..73, 95%CI: 0.26 to 2.06; p = 0.5520). These data suggest that the widespread prescription of PPI for stress ulcer prophylaxis in acute care facilities may contribute to the increased incidence of CDAD...
  18. ncbi Histaminergic H1 receptors mediate L-histidine-induced anxiety in elevated plus-maze test in mice
    Kuchibhotla Vijaya Kumar
    Neuropharmacology Unit, Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Behav Pharmacol 18:213-7. 2007
    ..Our results indicate that anxiogenic effects of central histaminergic system appear to be mediated prominently by activation of H1 receptors...
  19. ncbi Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta-analysis
    Alan N Barkun
    Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Am J Gastroenterol 107:507-20; quiz 521. 2012
    ..The objective of this study was to evaluate the efficacy of PPIs vs. H2RAs in the prophylaxis of SRMB in critically ill adults with risk factors for bleeding...
  20. pmc Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells
    S Matsumoto
    Department of Surgery, Second Teaching Hospital, School of Medicine, Fujita Health University, 3 6 10 Otohbashi, Nakagawa Ku, Nagoya 454 8509, Japan
    Br J Cancer 86:161-7. 2002
    ..0% and that of control group was 85.7% (P=n.s.)). These results clearly indicate that cimetidine treatment dramatically improved survival in colorectal cancer patients with tumour cells expressing high levels of sL(x) and sL(a)...
  21. ncbi Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus
    Luciana Pereira do Vale Cofiel
    Laboratory of Neuroscience, Universidade Federal de Sao Carlos, Sao Carlos, SP Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:1246-50. 2006
    ..Thus, it can be suggested that both receptors, H(1) and H(2), are involved in the acquisition of a new task in this species...
  22. ncbi Co-prescription of gastroprotective agents in patients taking non-selective NSAIDs or COX-2 selective inhibitors: analysis of prescriptions
    L Pasina
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Int J Clin Pharmacol Ther 48:735-43. 2010
    ....
  23. ncbi Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells
    Junpeng Wang
    State Key Laboratories of Agro biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Biochem Biophys Res Commun 372:491-6. 2008
    ..Collectively these findings suggest that CIM enhances the immune responses of HBV DNA vaccine through the stimulation of pro-inflammatory and inhibition of anti-inflammatory cytokine expression patterns...
  24. ncbi The effects of histaminergic agents in the central amygdala of rats in the elevated plus-maze test of anxiety
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
    Behav Pharmacol 16:643-9. 2005
    ..5 microl bilateral. The results suggest that histamine may modulate anxiety via H1 but not H2 receptors in the rat central amygdala...
  25. ncbi Overutilization of proton pump inhibitors: a review of cost-effectiveness and risk [corrected]
    Joel J Heidelbaugh
    Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Gastroenterol 104:S27-32. 2009
    ....
  26. ncbi Cimetidine-induced vascular cell apoptosis impairs testicular microvasculature in adult rats
    Flávia L Beltrame
    Department of Morphology and Genetics, Federal University of Sao Paulo UNIFESP, Sao Paulo SP, Brazil
    Histol Histopathol 27:1343-51. 2012
    ..A possible antagonist effect of cimetidine on the H₂ receptors and/or androgen receptors in the vascular cells may be responsible for the impairment of the testicular microvasculature...
  27. ncbi Does famotidine enhance tumor infiltrating lymphocytes in breast cancer? Results of a randomized prospective pilot study
    Rajinder Parshad
    Department of Surgery, All India Institute of Medical Sciences, New Delhi
    Acta Oncol 41:362-5. 2002
    ..01). This study suggests that famotidine enhances tumor infiltrating lymphocytes in breast cancer and might have potential as an immunomodulator. A larger confirmatory study is suggested...
  28. pmc Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression
    Masakatsu Fukuda
    Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    BMC Cancer 8:376. 2008
    ..We further demonstrated that cimetidine inhibited NCAM expression and induced apoptosis in HSG cells. Here, we investigated the effects of cimetidine on growth and perineural/neural invasion of salivary gland tumor cells...
  29. ncbi Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages
    Eu Jin Cho
    Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130 701, Republic of Korea
    J Cell Biochem 112:3648-59. 2011
    ..Taken together, these results indicate that the anti-inflammatory properties of roxatidine in LPS-treated RAW 264.7 macrophages are mediated by the inhibition of NF-κB transcriptional activity and the p38 MAP kinase pathway...
  30. ncbi Gastro-oesophageal reflux disease
    Paul Moayyedi
    Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, ON, Canada
    Lancet 367:2086-100. 2006
    ..The role of endoscopic therapy is uncertain. Anti-reflux surgery is probably as effective as PPI therapy although there is a low operative mortality and morbidity...
  31. ncbi Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial
    Ali S Taha
    Gastroenterology Unit, Crosshouse Hospital, University of Glasgow, Kilmarnock, UK
    Lancet 374:119-25. 2009
    ..We therefore investigated the efficacy of famotidine, a well-tolerated histamine H(2)-receptor antagonist, in the prevention of peptic ulcers and erosive oesophagitis in patients receiving low-dose aspirin for vascular protection...
  32. ncbi Nonerosive reflux disease--current concepts and dilemmas
    R Fass
    Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, USA
    Am J Gastroenterol 96:303-14. 2001
    ..Treatment with acid inhibitory agents is effective, and proton pump inhibitors are the most effective form of therapy...
  33. ncbi Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 79:76-83. 2006
    ..In all cases, the changes in risk estimates were small and the clinical significance was limited...
  34. pmc Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK
    L A Garcia Rodriguez
    Department of Surgery, P9 03, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Gut 55:1538-44. 2006
    ..Gastric acid suppressing drugs (that is, histamine(2) receptor antagonists and proton pump inhibitors) could affect the risk of oesophageal or gastric adenocarcinoma but few studies are available...
  35. ncbi Clinical outcome and influencing factors of a new short-term quadruple therapy for Helicobacter pylori eradication: a randomized controlled trial (MACLOR study)
    Gerhard Treiber
    Department of Gastroenterology Hepatology, University Hospital of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Arch Intern Med 162:153-60. 2002
    ..Short-term therapies for eradicating Helicobacter pylori in selected patients might offer advantages in terms of costs, compliance, and adverse effects in contrast to standard 1-week triple therapy...
  36. ncbi Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor
    J Mark Ruscin
    Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262 0001, USA
    Ann Pharmacother 36:812-6. 2002
    ..To report a case of vitamin B(12) deficiency associated with long-term use (approximately 4 1/2 y) of histamine(2) (H(2))-receptor antagonists and a proton-pump inhibitor (PPI) in a patient with gastroesophageal reflux...
  37. ncbi Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study
    Douglas J Robertson
    VA Medical Center, White River Junction, VT 05009, USA
    Gastroenterology 133:755-60. 2007
    ....
  38. pmc Histaminergic signaling in the central nervous system of Daphnia and a role for it in the control of phototactic behavior
    Matthew D McCoole
    Department of Toxicology, College of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA
    J Exp Biol 214:1773-82. 2011
    ..Taken collectively, our results show that an extensive histaminergic system is present in Daphnia species, including the visual system, and that this amine is involved in the control of phototaxis in these animals...
  39. pmc Histamine inhibits the production of interleukin-12 through interaction with H2 receptors
    T C van der Pouw Kraan
    CLB, Sanquin Blood Supply Foundation, Department of Auto Immune Diseases, Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, 1066CX Amsterdam, The Netherlands
    J Clin Invest 102:1866-73. 1998
    ..The observation that histamine strongly reduces the production of the Th1-inducing cytokine IL-12 implies a positive feedback mechanism for the development of Th2 responses in atopic patients...
  40. ncbi A new mechanism for anti-inflammatory actions of proton pump inhibitors--inhibitory effects on neutrophil-endothelial cell interactions
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Aliment Pharmacol Ther 14:74-81. 2000
    ..Neutrophil-endothelial cell interactions mediated by adhesion molecules may be involved in gastric mucosal inflammation associated with Helicobacter pylori or nonsteroidal anti-inflammatory drugs...
  41. ncbi A comparison of two prophylactic regimens for hypersensitivity reactions to paclitaxel
    Janice S Kwon
    Division of Gynecologic Oncology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada
    Gynecol Oncol 84:420-5. 2002
    ....
  42. pmc Acid-suppressive medications and risk of bone loss and fracture in older adults
    Elaine W Yu
    Endocrine Division, Massachusetts General Hospital, Thier 1101, 50 Blossom Street, Boston, MA 02114, USA
    Calcif Tissue Int 83:251-9. 2008
    ..The use of PPIs in older women, and perhaps older men with low calcium intake, may be associated with a modestly increased risk of nonspine fracture...
  43. ncbi A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults
    Robert J Valuck
    School of Pharmacy, University of Colorado Health Sciences Center, 4200 E 9th Ave, C 238, Denver, CO 80262, USA
    J Clin Epidemiol 57:422-8. 2004
    ..The purpose of this study was to examine the possible association between use of prescription histamine H-2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) and vitamin B(12) deficiency in older adults...
  44. ncbi Meta-analysis: proton pump inhibitor or H2-receptor antagonist for Helicobacter pylori eradication
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 17:1229-36. 2003
    ..To compare H2-receptor antagonists and proton pump inhibitors as adjuvants to triple therapy for Helicobacter pylori eradication...
  45. ncbi [Effect of maintenance therapy by H2RA on the recurrence of gastric and duodenal ulcer and on the occurrence of reflux esophagitis, gastric erosions, and duodenal erosions after H. pylori eradication]
    Shingo Maeyama
    Department of Gastroenterology, Osaka Rosai Hospital
    Nihon Rinsho 63:512-5. 2005
  46. ncbi Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates
    F De Vries
    Utrecht Institute for Pharmaceutical Sciences, Universiteit Utrecht, Utrecht, The Netherlands
    Osteoporos Int 20:1989-98. 2009
    ..Positive associations were observed for any hip and vertebral fracture. The effect size was modest; however, the significance lies in the widespread prescribing of acid suppressants...
  47. ncbi Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors
    I J Elenkov
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Immunol 161:2586-93. 1998
    ....
  48. ncbi Lafutidine, a newly developed antiulcer drug, elevates postprandial intragastric pH and increases plasma calcitonin gene-related peptide and somatostatin concentrations in humans: comparisons with famotidine
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Dis Sci 51:114-20. 2006
    ..We concluded that lafutidine increases plasma concentrations of CGRP and somatostatin in humans, which may result in inhibition of postprandial acid secretion and gastroprotective activity...
  49. ncbi Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    FASEB J 19:656-8. 2005
    ..In line with our previous animal experiments, our data strongly suggest that anti-ulcer treatment primes the development of IgE toward dietary compounds in long-term acid-suppressed patients...
  50. ncbi Effect of lafutidine, a histamine H2-receptor antagonist, on gastric mucosal blood flow and duodenal HCO3- secretion in rats: relation to capsaicin-sensitive afferent neurons
    Hiroshi Mimaki
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    Dig Dis Sci 47:2696-703. 2002
    ..The luminal H+ itself is not a ligand for the RT-sensitive site of VR1 but plays a modulator role in the CSN-mediated physiological responses...
  51. pmc Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins
    Kazuhiro Fukushima
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan
    World J Gastroenterol 12:3031-7. 2006
    ..We compared the effect between lafutidine and capsaicin, with respect to the interaction with endogenous prostaglandins (PG), nitric oxide (NO) and the afferent neurons, including transient receptor potential vanilloid subtype 1 (TRPV1)...
  52. ncbi Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review)
    Florence Lefranc
    Department of Neurosurgery, Erasmus University Hospital, Brussels, Belgium
    Int J Oncol 28:1021-30. 2006
    ....
  53. ncbi Primary-care physicians' perceptions and practices on the management of GERD: results of a national survey
    William D Chey
    University of Michigan Health System, Ann Arbor, Michigan 49109 0362, USA
    Am J Gastroenterol 100:1237-42. 2005
    ..Gastroesophageal reflux disease (GERD) is frequently managed by primary-care physicians (PCPs) although little is known about their current practices and management patterns...
  54. ncbi Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Invest Dermatol 116:261-5. 2001
    ..In conclusion, both the histamine H1 and H2 receptors in the epidermis are involved in skin barrier function and the cutaneous condition of epidermal hyperplasia...
  55. ncbi Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa
    Takafumi Ichikawa
    Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Japan
    J Gastroenterol Hepatol 22:1800-5. 2007
    ..Previous human studies have not assessed its gastroprotective effects. The purpose of the present study was to determine the effects of lafutidine on the human gastric mucus layer using both histological and biochemical methods...
  56. ncbi Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats
    Naoaki Harada
    Department of Biodefense Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Dig Dis Sci 52:469-77. 2007
    ..These observations suggest that lafutidine might reduce WIR-induced gastric mucosal injury not only by inhibiting acid secretion but also by inhibiting neutrophil activation through enhancement of sensory neuron activation...
  57. pmc Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth
    J A Lawson
    UNSW Department of Surgery, The St George Hospital, Kogarah Sydney, Australia
    Br J Cancer 73:872-6. 1996
    ..LIM2412, another colonic cancer cell line, was significantly stimulated by both cimetidine and ranitidine in vivo. Ranitidine had no effect on in vitro cell proliferation...
  58. ncbi Effect of proton pump inhibitors and H2 antagonists on the stomach wall in 99mTc-sestamibi cardiac imaging
    Sumina Goel
    Division of Nuclear Medicine, Department of Radiology, St Luke s Roosevelt Hospital, and Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Nucl Med Technol 37:240-3. 2009
    ..We prospectively evaluated the frequency of stomach wall uptake in patients undergoing myocardial perfusion SPECT who were taking PPIs or H(2) antagonists...
  59. ncbi An effective and more convenient drug regimen for prophylaxis against paclitaxel-associated hypersensitivity reactions
    M Markman
    Department of Hematology Medical Oncology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cancer Res Clin Oncol 125:427-9. 1999
    ....
  60. pmc Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness
    Stephen Brett
    Department of Anaesthetics and Intensive Care, Hammersmith Hospital, London, UK
    Crit Care 9:45-50. 2005
    ..This review seeks to present the pharmacological evidence that may inform decision-making about the prescription of drugs for prophylaxis of SRMD...
  61. ncbi Does cimetidine improve prospects for cancer patients?. A reappraisal of the evidence to date
    C P Siegers
    Department of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Germany
    Digestion 60:415-21. 1999
    ..Since then, several studies have appeared which suggest an anticancer activity for cimetidine, although few attempts have been made to corroborate their findings in large, placebo-controlled, double-blind studies...
  62. ncbi Gastroprotective mechanism of lafutidine, a novel anti-ulcer drug with histamine H2-receptor antagonistic activity
    S Onodera
    Pharmaceuticals Research Laboratories, Fujirebio Inc, Tokyo, Japan
    Arzneimittelforschung 49:519-26. 1999
    ....
  63. ncbi Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial
    Corine J Van Marrewijk
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet 373:215-25. 2009
    ..We compared step-up and step-down treatment strategies for initial management of patients with new onset dyspepsia in primary care...
  64. ncbi Stress ulcer prophylaxis in critically ill patients: a randomized controlled trial
    Ilona Kantorova
    Traumatological Hospital Brno, Research Center for Traumatology and Surgery, Czech Republic
    Hepatogastroenterology 51:757-61. 2004
    ..There are conflicting data on the efficacy and complication rates of various prophylactic regimens...
  65. pmc Proton pump inhibitors and risk of gastric cancer: a population-based cohort study
    A H Poulsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Br J Cancer 100:1503-7. 2009
    ....
  66. ncbi Protective effect of lafutidine, a novel histamine H2-receptor antagonist, on dextran sulfate sodium-induced colonic inflammation through capsaicin-sensitive afferent neurons in rats
    Mitsuaki Okayama
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    Dig Dis Sci 49:1696-704. 2004
    ..This action might be attributable at least partly to the enhancement of colonic mucus secretion...
  67. pmc Prospective, double-blind, placebo-controlled randomized trial of cimetidine in gastric cancer. British Stomach Cancer Group
    M J Langman
    Department of Medicine, CRC Institute for Cancer Studies, Clinical Research Block, The Medical School, Edgbaston, Birmingham, UK
    Br J Cancer 81:1356-62. 1999
    ..Cimetidine at a dose of 400 mg or 800 mg twice a day does not have a significant influence on the survival of patients with gastric cancer compared to placebo...
  68. ncbi Efficacy and tolerability of 20 mg pantoprazole versus 300 mg ranitidine in patients with mild reflux-oesophagitis: a randomized, double-blind, parallel, and multicentre study
    J H Van Zyl
    Department of Medicine and Gastroenterology at University of The Orange Free State, Bloemfontein, South Africa
    Eur J Gastroenterol Hepatol 12:197-202. 2000
    ....
  69. ncbi Intravenous proton-pump inhibitors versus H2-antagonists for treatment of GI bleeding
    Rebecca M Huggins
    Department of Pharmacy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Pharmacother 37:433-7. 2003
    ..To evaluate the evidence supporting the use of intravenous proton-pump inhibitors in the treatment of gastrointestinal (GI) hemorrhage in comparison with histamine(2) (H(2))-receptor antagonists...
  70. ncbi H(2) antagonist-induced thrombocytopenia: is this a real phenomenon?
    Emily E Wade
    Department of Pharmacy, University of Pittsburgh Medical Center, 304 Scaife Hall, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Intensive Care Med 28:459-65. 2002
    ..We evaluate the literature to better define thrombocytopenia related to H(2) antagonist administration and discuss mechanism, potential as a risk factor and case reports describing the severity and duration of thrombocytopenia...
  71. ncbi Standard-dose lansoprazole is more effective than high-dose ranitidine in achieving endoscopic healing and symptom relief in patients with moderately severe reflux oesophagitis. The Dutch Lansoprazole Study Group
    J B Jansen
    Department of Gastroenterology, Academic Hospital Nijmegen St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 13:1611-20. 1999
    ..In an attempt to compensate for the lower efficacy, H2-receptor antagonists are now increasingly being used at a higher dose...
  72. ncbi Current guidelines on stress ulcer prophylaxis
    M Tryba
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Bergmannsheil, Bochum, Germany
    Drugs 54:581-96. 1997
    ..The clinical relevance of nosocomial pneumonia due to gastric bacterial overgrowth has decreased during the past decade due to several changes in the management of critically ill patients...
  73. ncbi Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3
    Yoshinori Nagata
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Drug Metab Dispos 32:1040-7. 2004
    ..These results suggest that rOat3 is the most likely candidate transporter involved in regulating the CSF concentration of H(2)-receptor antagonists at the CP...
  74. ncbi [Eradication of Helicobacter pylori infection in Europe: a meta-analysis based on congress abstracts, 1997-2002]
    György Miklós Buzás
    Ferencvárosi Egészségügyi Szolgálat, Gasztroenterológia
    Orv Hetil 145:2035-41. 2004
    ..Meta-analyses evaluated several aspects of Helicobacter pylori eradication based on the randomised controlled trials...
  75. ncbi The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach
    Kun Wang
    Division of Gastroenterology, Department of Medicine, Cardinal Tien Hospital and School of Medicine Fu Jen Catholic University, Taipei, Taiwan, ROC
    Hepatogastroenterology 51:1540-3. 2004
    ..The purpose of this study was to investigate the microbial condition of the stomach in patients who received H2-receptor antagonist or proton pump inhibitor...
  76. ncbi Heartburn-dominant, uninvestigated dyspepsia: a comparison of 'PPI-start' and 'H2-RA-start' management strategies in primary care--the CADET-HR Study
    D Armstrong
    Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 21:1189-202. 2005
    ..There are few data on empiric, stepped therapy for heartburn relief or subsequent relapse in primary care...
  77. ncbi [PPI: new strategies for GERD]
    Etsuo Hoshino
    Department of Internal Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research
    Nihon Rinsho 62:1570-6. 2004
    ..A small number of GERD patients resistant to PPI therapy may be due to nocturnal acid breakthrough (NAB) or rapid metabolism of PPI (extensive metabolizer for CYP2C19)...
  78. ncbi Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs
    Alexa M E Bersenas
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Am J Vet Res 66:425-31. 2005
    ..To identify the normal gastric acid secretion profile in dogs and determine the degree of gastric acid suppression associated with 4 gastric acid suppressants...
  79. ncbi The effect of rabeprazole alone or in combination with H2 receptor blocker on intragastric pH: a pilot study
    Murat Toruner
    Department of Gastroenterology, Ankara University Medical School, Ankara, Turkey
    Turk J Gastroenterol 15:225-8. 2004
    ..The aim of our study was to evaluate the effects of proton pump inhibitors alone or in combination with H2 receptor blockers on gastric acidity with 24-hour gastric pH monitoring...
  80. ncbi [Treatment of gastroesophageal reflux disease]
    Laszlo Herszenyi
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 144:2571-3. 2003
  81. ncbi [Bronchial asthma and gastroesophageal reflux disease: are they interrelated by chance?]
    N R Paleev
    Klin Med (Mosk) 83:9-14. 2005
  82. ncbi Effects of cimetidine-like drugs on recombinant GABAA receptors
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12206, USA
    Life Sci 75:2551-8. 2004
    ....
  83. ncbi Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced upregulation
    Satoshi Osawa
    First Dept of Medicine, Hamamatsu Univ School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G880-9. 2005
    ..These findings suggested that upon exposure to an antagonist (inverse agonist), the equilibrium between receptor endocytosis and recycling is altered before H2R upregulation, probably via suppressing H2R degradation...
  84. ncbi [Modern attitude towards management of laryngopharyngeal form of gastroesophageal reflux disease. Lithuanian clinical practice guidelines for adults]
    Nora Siupsinskiene
    Department of Otorhinolaryngology, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 43:832-9. 2007
    ..Combined therapy for nonresponders is described. Algorithm for stopping the medication is recommended. These recommendations may provide an efficient and economical approach to the management of this problem...
  85. ncbi In vitro availability studies of enoxacin in presence of H2 receptor antagonists
    M Saeed Arayne
    Department of Chemistry, University of Karachi Karachi 75270, Pakistan
    Pak J Pharm Sci 20:235-43. 2007
    ....
  86. ncbi [Safety of proton pump inhibitors]
    Juan V Esplugues
    Departamento de Farmacologia, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, Espana
    Med Clin (Barc) 127:790-5. 2006
    ..After two decades of use, PPIs have proved to be very effective and safe drugs...
  87. ncbi Fosinopril H(2)-receptor antagonists interaction studies by derivative spectroscopy
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:19-25. 2007
    ....
  88. ncbi In vitro interactions of captopril with H2-receptor antagonists
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:132-9. 2007
    ..As a result, the availability of captopril was affected by the concurrent administration of H2-receptor antagonists. Accordingly coadministration of both the drugs should be avoided...
  89. ncbi Spectrophotometric determination of H(2)-receptor antagonists via their oxidation with cerium(IV)
    Ibrahim A Darwish
    Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 69:33-40. 2008
    ..3-102.6+/-0.57-1.90%) without interference from the common excipients. The results obtained by the proposed method were comparable with those obtained by the official methods...
  90. ncbi [Pharmacological efficacy of bismuth tripotassium dicitrate in peptic ulcer]
    Iu B Belousov
    Ter Arkh 79:58-66. 2007
  91. ncbi Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates
    K I Umehara
    Drug Metabolism Research Laboratories, Drug Discovery Research, Azusawa, Tokyo, Japan
    Xenobiotica 37:618-34. 2007
    ..The acquisition of information on OCT/Oct mediated-transport and/or inhibition such as that presented in this report is very useful for further understanding of certain aspects of uptake, distribution, and excretion for drug candidates...
  92. ncbi Simple and universal HPLC-UV method to determine cimetidine, ranitidine, famotidine and nizatidine in urine: application to the analysis of ranitidine and its metabolites in human volunteers
    Diane A I Ashiru
    Department of Pharmaceutics, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 860:235-40. 2007
    ..The assay was successfully applied to a human volunteer study using ranitidine as the model compound...
  93. ncbi Relationship between histamine2-receptor antagonist medications and risk of invasive breast cancer
    Robert W Mathes
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:67-72. 2008
    ..The few previous studies evaluating this association have been null but have been limited by small sample sizes, and none have evaluated risk by either histologic type or estrogen receptor/progesterone receptor status...
  94. ncbi [The effect of H2 receptor blockers on renal function. An attempt to accurately measure glomerular filtration]
    Waldemar Motyl
    Z Oddziału Wewnetrznego Szpitala Powiatowego w Drawsku Pomorskim, ul Bolesława Chrobrego 4, 78 500 Drawsko Pomorskie
    Ann Acad Med Stetin 50:97-105. 2004
    ..The present findings suggest that the full dose of cimetidine is capable of inhibiting tubular transport of creatinine and thus may improve the accuracy of creatinine clearance measurements for the study of renal function...
  95. ncbi Nasal pain disrupting sleep as a presenting symptom of extraesophageal acid reflux in children
    Seckin Ulualp
    Department of Otolaryngology, University at Buffalo, School of Medicine and Biomedical Sciences and the Women and Children s Hospital, 219 Bryant Street, Buffalo, NY 14209, USA
    Int J Pediatr Otorhinolaryngol 69:1555-7. 2005
    ..This is the first report documenting nasal pain resolved with acid suppressive therapy in a child with EERD. The incidence and pathogenesis of EERD induced nasal symptoms in children merits further investigation...
  96. ncbi The efficacy of preanesthetic proton pump inhibitor treatment for patients on long-term H2 antagonist therapy
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Anesth Analg 101:1038-41, table of contents. 2005
    ..05) were at risk. These data suggest that in patients receiving H2-antagonist therapy for longer than 4 wk, prophylaxis for acid aspiration pneumonia should include preanesthetic PPI medication...
  97. ncbi Continuous infusion interleukin-2 and antihistamines in metastatic kidney cancer
    Paul R Walker
    Division of Medical Oncology and Hematology, Medical University of Ohio at Toledo, Ruppert Center, 3120 Glendale Avenue, Toledo, OH 43614, USA
    Cancer Biother Radiopharm 20:487-90. 2005
    ..In this study of CIV IL-2 and antihistamines, this combination appears to be active in metastatic kidney cancer. There appears to be no negative effect of antihistamine on the CIV IL-2 response rate in this disease...
  98. ncbi "Proton-pump inhibitor-first" strategy versus "step-up" strategy for the acute treatment of reflux esophagitis: a cost-effectiveness analysis in Japan
    Yasuki Habu
    Department of Gastroenterology, Saiseikai Noe Hospital, 2 2 33 Imafuku Higashi Joto ku, Osaka 536 0002, Japan
    J Gastroenterol 40:1029-35. 2005
    ..e., proton-pump inhibitors (PPIs), can be given first, or histamine H2-receptor antagonists (H2RAs) can be attempted first (the "step-up" approach)...
  99. ncbi [A randomized, prospective, comparative, multicenter study of rabeprazole and ranitidine in the treatment of reflux esophagitis]
    Hyun Yong Jeong
    Department of Internal Medicine, Chungnam National University College of Medicine, Chungnam, Korea
    Korean J Gastroenterol 47:15-21. 2006
    ..This study was done to evaluate the efficacy of rabeprazole (proton-pump-inhibitor) and ranitidine (H(2)-receptor antagonist) in the symptom relief and treatment of erosive esophagitis diagnosed by endoscopy...
  100. pmc Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection
    Scott A Handley
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:9268-73. 2006
    ..In this study, we provide evidence that histamine signaling through the histamine H(2) but not the H(1) receptor is important for controlling Y. enterocolitica infection within the Peyer's patches and mesenteric lymph nodes of mice...
  101. ncbi In vitro availability of metformin in presence of h(2) receptor antagonists
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:28-34. 2006
    ..On the other hand, increase in metformin concentration may result in hypoglycemic effects...

Research Grants43

  1. CASE-CONTROL SURVEILLANCE OF SERIOUS ILLNESSES AND DRUGS
    Lynn Rosenberg; Fiscal Year: 2007
    ..One focus of CCS analyses will be the relation of the widely used drug classes, statins, histamine H2 antagonists, and selective serotonin uptake inhibitors, to risk of common cancers...
  2. NSAIDS and Other Medications in Prostate Cancer Etiology
    Janet Stanford; Fiscal Year: 2005
    ..Results of the study may provide unique insights on the pathogenesis of this complex disease and lead to innovative strategies for prostate cancer prevention. ..
  3. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
  4. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..Hence this approach will provide additional insights into mechanisms of regulation of gastric secretion and enable illuminated interpretation of the pathophysiology of peptic ulcer disease. ..
  5. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  6. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  7. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  8. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  9. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  10. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  11. The Perception of Cancer Risk in Patients with Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2007
    ..The resultant study application will assess health-related quality of life, health-related anxiety and healthcare utilization as outcomes. [unreadable] [unreadable]..
  12. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  13. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  14. The CASCADE Study: End-of-Life in Advanced Dementia
    Susan Mitchell; Fiscal Year: 2008
    ..abstract_text> ..
  15. Enteric flora modulates the development of colitis
    Albert Jergens; Fiscal Year: 2008
    ..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
  16. Prophylactic Phenobarbital After Resolution of Neonatal Seizures
    Ronnie Guillet; Fiscal Year: 2010
    ..This clinical trial is designed to help answer that question and provide data that will help determine standard of care for these children. ..
  17. The ADEPT Study: Estimating Prognosis in Advanced Dementia
    Susan Mitchell; Fiscal Year: 2009
    ..Thus, the information derived from this study has the potential to make important clinical, research and policy-relevant contributions to the care of older persons with dementia at the end-of-life. ..
  18. Naturally occurring T regulatory cells control airway hyperresponsiveness
    Erwin Gelfand; Fiscal Year: 2008
    ..abstract_text> ..
  19. Effect of Urban Form on Exercise and BMI in Black Women
    Patricia Coogan; Fiscal Year: 2009
    ..The proposed study has the potential to provide such evidence and to impact policy in the domains of both transportation/urban planning and public health. ..
  20. Steroid Hormone Genes and Ovarian Cancer Risk
    Mary Anne Rossing; Fiscal Year: 2010
    ..The proposed study, by expanding our knowledge of the role of progestogens, estrogens, and androgens in the development of ovarian cancer, will inform efforts to develop effective strategies to prevent this disease. ..
  21. Epidemiology and Incidence of Barrett's Esophagus
    DOUGLAS ALLEN CORLEY; Fiscal Year: 2010
    ..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
  22. Cognitive Pathways to Disability
    Michelle Carlson; Fiscal Year: 2006
    ..abstract_text> ..
  23. Tube-feeding in Elderly: Decision-making and Outcomes
    Susan Mitchell; Fiscal Year: 2003
    ..By the end of the award period the applicant will have the skills, experience and research track record necessary to become an independent investigator and leader in academic geriatrics. ..
  24. Use of Antidepressants and Risk of Breast Cancer
    MARY ROSSING; Fiscal Year: 2003
    ..g., SSRIs or tricyclics), and individual drugs such as fluoxetine and paroxetine. Use of the pharmacy database will provide unbiased and complete exposure data relative to previous studies based on self-reported drug use. ..
  25. BENZODIAZEPINE USE AND RISK OF DISABILITY IN THE ELDERLY
    Shelly Gray; Fiscal Year: 2003
    ....
  26. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
  27. NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Laura James; Fiscal Year: 2004
    ..abstract_text> ..
  28. A MICROSURGICAL INVESTIGATION OF GASTRIC ACID SECRETION
    John Geibel; Fiscal Year: 2004
    ..abstract_text> ..
  29. CASE CONTROL STUDY OF STATIN USE AND LARGE BOWEL CANCER
    Patricia Coogan; Fiscal Year: 2004
    ..S. men and women are high, an inverse association would be of considerable public health importance. Moreover, it would shed light on a mechanism of colon carcinogenesis. ..
  30. EPIDEMIOLOGY OF SMOKING CESSATION--GENETIC INFLUENCES
    MARY ROSSING; Fiscal Year: 2002
    ..In the future, such knowledge may allow the identification of subgroups of individuals who are most likely to benefit from particular pharmacologic interventions. ..
  31. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  32. Epidemiologic Case-control Study of Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2005
    ..Finally, by comparing subjects with Barrett's to controls with reflux, and controlling for severs of reflux, the impact of a Barrett's diagnosis on quality of life and psychological stress may be seen. ..
  33. SAMe Inhibits Inflammatory-mediated Enhanced Toxicity
    JANE MADDOX; Fiscal Year: 2003
    ..Moreover, they may provide evidence for development of related therapeutic compounds. ..
  34. Evaluation of a Biomarker for Acetaminophen Toxicity
    Laura James; Fiscal Year: 2005
    ..The data generated from this study will lead to enhanced recognition of APAP hepatotoxicity, thus allowing for better identification of "at risk" populations and the creation of prevention strategies. ..
  35. Treatment after Resolution of Neonatal Seizures
    Ronnie Guillet; Fiscal Year: 2006
    ..The personnel and resources of the Network will be available for consultation and collaboration during the planning phase, as well as for initiation and performance of the RCT. ..
  36. Epidemiology of Ovarian Cancer:New Hypotheses
    MARY ROSSING; Fiscal Year: 2006
    ..abstract_text> ..
  37. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..The results of these experiments will enhance the understanding of maternal-fetal PG signaling, and are likely to provide new insights into premature or dysfunctional labor in women. ..
  38. Mechanisms of Ductus Arteriosus Regulation
    JOHN JEFFREY REESE; Fiscal Year: 2010
    ..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
  39. Enhancing Care for Hospitalized Older Adults with CI
    Malaz Boustani; Fiscal Year: 2008
    ..abstract_text> ..
  40. Alzheimer Screening in Primary Care: PRISM-PC Study
    Malaz Boustani; Fiscal Year: 2009
    ..Future directions: We anticipate that participants'responses could guide the design of specific counseling and educational interventions to overcome a patients'reluctance to accept dementia screening. ..