histamine h1 antagonists

Summary

Summary: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

Top Publications

  1. ncbi Histamine and H1-antihistamines: celebrating a century of progress
    F Estelle R Simons
    Department of Pediatrics and Child Health and the Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Allergy Clin Immunol 128:1139-1150.e4. 2011
  2. ncbi The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
    C Privou
    Institute of Physiological Psychology I and Center for Biological and Medical Research, University of Dusseldorf, Germany
    Neuropharmacology 37:1019-32. 1998
  3. ncbi Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments
    Consuelo García-Gea
    Centre d Investigacio de Medicaments, Institut de Recerca, Servei de Farmacologia Clinica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Clin Psychopharmacol 28:675-85. 2008
  4. ncbi The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome
    Tamira K Klooker
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Gut 59:1213-21. 2010
  5. ncbi An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis
    P A Klein
    Department of Dermatology, State University of New York at Stony Brook, 11794 8165, USA
    Arch Dermatol 135:1522-5. 1999
  6. ncbi Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model
    K M Vural
    Department of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Ann Thorac Surg 69:228-32. 2000
  7. ncbi Histamine and histamine receptor antagonists in cancer biology
    Bruno Blaya
    Department of Cell Biology and Histology, University of the Basque Country, Bizkaia, Spain
    Inflamm Allergy Drug Targets 9:146-57. 2010
  8. ncbi H1-histamine receptors in the amygdala are involved in emotional memory but do not mediate anxiety-related behaviors in mice submitted to EPM testing
    K R Serafim
    Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod Washington Luis, Sao Carlos, Brazil
    Brain Res Bull 89:1-7. 2012
  9. ncbi Safety and efficacy of bilastine: a new H(1)-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria
    Martin K Church
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117, Berlin, Germany
    Expert Opin Drug Saf 10:779-93. 2011
  10. ncbi Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/I kappa B/NF-kappa B signal cascades
    Masahiro Matsubara
    Department of Pharmacology and Molecular Biology, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, Shizuoka 411 8731, Japan
    Biochem Pharmacol 69:433-49. 2005

Research Grants

Detail Information

Publications227 found, 100 shown here

  1. ncbi Histamine and H1-antihistamines: celebrating a century of progress
    F Estelle R Simons
    Department of Pediatrics and Child Health and the Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Allergy Clin Immunol 128:1139-1150.e4. 2011
    ..Additional novel compounds being studied include H(4)-antihistamines with anti-inflammatory effects in allergic rhinitis, atopic dermatitis, and other diseases. Antihistamines have a storied past and a promising future...
  2. ncbi The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
    C Privou
    Institute of Physiological Psychology I and Center for Biological and Medical Research, University of Dusseldorf, Germany
    Neuropharmacology 37:1019-32. 1998
    ....
  3. ncbi Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments
    Consuelo García-Gea
    Centre d Investigacio de Medicaments, Institut de Recerca, Servei de Farmacologia Clinica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Clin Psychopharmacol 28:675-85. 2008
    ..The 40-mg dose of BIL produced subjective report of sedation, whereas unwanted objective CNS side effects were observed only with the 80-mg dose...
  4. ncbi The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome
    Tamira K Klooker
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Gut 59:1213-21. 2010
    ..A study was therefore undertaken to investigate the effect of the mast cell stabiliser ketotifen on rectal sensitivity and symptoms in patients with IBS...
  5. ncbi An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis
    P A Klein
    Department of Dermatology, State University of New York at Stony Brook, 11794 8165, USA
    Arch Dermatol 135:1522-5. 1999
    ..To critically review the body of clinical trials that refute or support the efficacy of antihistamines in relieving pruritus in patients with atopic dermatitis...
  6. ncbi Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model
    K M Vural
    Department of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Ann Thorac Surg 69:228-32. 2000
    ....
  7. ncbi Histamine and histamine receptor antagonists in cancer biology
    Bruno Blaya
    Department of Cell Biology and Histology, University of the Basque Country, Bizkaia, Spain
    Inflamm Allergy Drug Targets 9:146-57. 2010
    ..These observations increase our understanding of cancer biology and may inspire novel anticancer therapeutic strategies...
  8. ncbi H1-histamine receptors in the amygdala are involved in emotional memory but do not mediate anxiety-related behaviors in mice submitted to EPM testing
    K R Serafim
    Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod Washington Luis, Sao Carlos, Brazil
    Brain Res Bull 89:1-7. 2012
    ..Taken together, these results suggest that the H(1) receptors in the amygdala are not implicated in anxiety-like behaviors but are involved in emotional states induced by the T1/T2 EPM protocol in mice...
  9. ncbi Safety and efficacy of bilastine: a new H(1)-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria
    Martin K Church
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117, Berlin, Germany
    Expert Opin Drug Saf 10:779-93. 2011
    ..A review of bilastine was undertaken to determine whether this newer H(1)-antihistamine meets these requirements...
  10. ncbi Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/I kappa B/NF-kappa B signal cascades
    Masahiro Matsubara
    Department of Pharmacology and Molecular Biology, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, Shizuoka 411 8731, Japan
    Biochem Pharmacol 69:433-49. 2005
    ..Thus, the anti-inflammatory benefit of H1 antagonists may be in part due to prevention of cytokine production...
  11. ncbi Lack of preventing effect of systemically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of acute atopic dermatitis
    Wolfgang Baumer
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Exp Dermatol 20:577-81. 2011
    ..In conclusion, the preventive administration of H1R or H4R antagonists has no impact on the development of acute skin lesions in this experimental canine atopic dermatitis model...
  12. ncbi Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action
    T Shimizu
    Departments of Dermatology Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Exp Allergy 34:103-9. 2004
    ..Cetirizine, a putative H1-receptor antagonist, has recently been shown to have anti-inflammatory properties through the inhibition of leucocyte recruitment and activation, and by the reduction of ICAM-1 expression on keratinocytes...
  13. ncbi P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists
    Cuiping Chen
    Pfizer Global Research and Development, Pfizer Inc, Groton, Connecticut 06340, USA
    Drug Metab Dispos 31:312-8. 2003
    ..In contrast, nonsedating H1-antagonists cetirizine, loratadine, and desloratadine are P-gp substrates. Affinity for P-gp at BBB may explain the lack of central nervous system side effects of modern H1-antagonists...
  14. ncbi Tolerance to daytime sedative effects of H1 antihistamines
    Gary S Richardson
    Sleep Disorders Clinic and Research Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Clin Psychopharmacol 22:511-5. 2002
    ..While other antihistamines and dosing regimens may differ, these results suggest that tolerance to the sedation produced by these drugs develops with remarkable rapidity...
  15. ncbi An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers
    I Hindmarch
    HPRU Medical Research Centre, University of Surrey, Guildford, UK
    Clin Exp Allergy 32:133-9. 2002
    ....
  16. ncbi Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography
    Manabu Tashiro
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Pharmacol 44:890-900. 2004
    ..H1RO was negligible with fexofenadine (-0.1%) but moderately high with cetirizine (26.0%). In conclusion, fexofenadine 120 mg is distinguishable from cetirizine 20 mg, as assessed by H1RO and psychomotor testing...
  17. ncbi H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells
    Shawkat Muhialdin Jangi
    Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa E 48940, and Department of Dermatology, Cruces Hospital, Vizcaya, Spain
    Carcinogenesis 27:1787-96. 2006
    ..The present results may contribute to the elaboration of novel therapeutic strategies for the treatment of malignant human melanoma...
  18. ncbi Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94
    J F O'Hanlon
    Institute for Human Psychopharmacology, University of Limburg, Maastricht, The Netherlands
    Allergy 50:234-42. 1995
    ..One or possibly two of the newer drugs possessed both performance-enhancing and -impairing properties, depending on dose, suggesting two mechanisms of action...
  19. ncbi Clinical pharmacokinetics of fexofenadine enantiomers
    Masatomo Miura
    Akita University Hospital, Department of Pharmacy, Akita 010 8543, Japan
    Expert Opin Drug Metab Toxicol 6:69-74. 2010
    ....
  20. ncbi Ameliorative effect of a hippocampal metabotropic glutamate- receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats
    Takayoshi Masuoka
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    J Pharmacol Sci 113:41-7. 2010
    ....
  21. ncbi Suppressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro
    Kazuhito Asano
    Department of Physiology, School of Medicine, Showa University, Tokyo, Japan
    Arzneimittelforschung 54:436-43. 2004
    ..The addition of FEX at 100 ng/ml scarcely affected the expression of RANTES and eotaxin mRNA. On the other hand, 250 ng/ ml of FEX significantly inhibited these mRNA expressions that were enhanced by LPS stimulation...
  22. ncbi The effects of histaminergic agents in the central amygdala of rats in the elevated plus-maze test of anxiety
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
    Behav Pharmacol 16:643-9. 2005
    ..5 microl bilateral. The results suggest that histamine may modulate anxiety via H1 but not H2 receptors in the rat central amygdala...
  23. ncbi Onset and duration of action of topical antihistamine: a study of histamine skin test response
    Retno Danarti
    Department of Dermatology and Venereology, Sardjito Hospital Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia
    Int J Dermatol 47:861-3. 2008
    ..In this study, we aimed to determine the onset and duration of action of single topical AH application by observing histamine-STR suppression over time...
  24. ncbi Histamine-induced activation of human lung macrophages
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 124:249-52. 2001
    ..Macrophages are primarily involved in inflammatory diseases of the lung. We explored the ability of low concentrations of histamine to induce the release of proinflammatory mediators from human lung macrophages...
  25. ncbi Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus
    Luciana Pereira do Vale Cofiel
    Laboratory of Neuroscience, Universidade Federal de Sao Carlos, Sao Carlos, SP Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:1246-50. 2006
    ..Thus, it can be suggested that both receptors, H(1) and H(2), are involved in the acquisition of a new task in this species...
  26. pmc Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function
    Tzu Kai Lin
    Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, California 94121, USA
    J Invest Dermatol 133:469-78. 2013
    ..These results could shift current paradigms of antihistamine utilization from a predominantly systemic to a topical approach...
  27. ncbi Histaminergic H1 receptors mediate L-histidine-induced anxiety in elevated plus-maze test in mice
    Kuchibhotla Vijaya Kumar
    Neuropharmacology Unit, Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Behav Pharmacol 18:213-7. 2007
    ..Our results indicate that anxiogenic effects of central histaminergic system appear to be mediated prominently by activation of H1 receptors...
  28. ncbi Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene
    G S Ratra
    Department of Toxicology, St Bartholomew s and the Royal London School of Medicine and Dentistry, United Kingdom
    Toxicol Sci 46:185-96. 1998
    ..Together this suggested that CYP2C11 was responsible for the suicide substrate bioactivation of methapyrilene and the toxicologic outcome largely relied upon an abundance of detoxifying enzymes present in the liver...
  29. ncbi Enhancement of clara cell 10-kD protein (CC10) production from nasal epithelial cells by fexofenadine hydrochloride
    Taketoshi Nogaki
    Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Japan
    Asian Pac J Allergy Immunol 30:139-45. 2012
    ..In the present study, we examined the influence of a histamine H1 receptor antagonist, fexofenadine hydrochloride (FEX) on CC10 production in vitro and in vivo...
  30. ncbi Safety considerations in the management of allergic diseases: focus on antihistamines
    K Yanai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Curr Med Res Opin 28:623-42. 2012
    ..g. allergic rhinitis and urticaria, and to compare them to the safety profiles of other medications, mostly topical corticosteroids and leukotriene antagonists (LTRA)...
  31. ncbi Assessment of protective effects of methylprednisolone and pheniramine maleate on reperfusion injury in kidney after distant organ ischemia: a rat model
    Serdar Bayrak
    Department of Cardiovascular Surgery, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
    Ann Vasc Surg 26:559-65. 2012
    ....
  32. ncbi Fixed drug eruption caused by three unrelated drugs: promethazine, pethidine and omeprazole
    Y Kai
    Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan
    Clin Exp Dermatol 36:755-8. 2011
    ..Seven months after that reaction, a more severe eruption was caused by oral omeprazole. This is an extremely rare case of FDE caused by three structurally unrelated drugs...
  33. ncbi Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury
    Neena Kalia
    Academic Unit of Surgical Oncology, Division of Clinical Sciences South, Royal Hallamshire Hospital, Sheffield, UK
    J Gastroenterol Hepatol 20:1032-8. 2005
    ..The purpose of the present study was to evaluate the effects of the mast cell stabilizer, ketotifen, on leukocyte adhesion within, and tissue leakage from the mucosal villous microcirculation after intestinal I/R...
  34. ncbi Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro
    Naruo Shoji
    Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Japan
    Int Arch Allergy Immunol 155:38-51. 2011
    ..Although several types of histamine H(1) receptor antagonist (antihistamine) have been developed and used for the treatment of allergic diseases, the influence of antihistamines on TARC and MDC production is not well understood...
  35. ncbi Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Psychopharmacology (Berl) 213:441-52. 2011
    ..Since chlorpheniramine inhibits the reuptake of serotonin (5-HT), the anxiolytic-like effect of chlorpheniramine may be produced by an increase in serotonergic function...
  36. ncbi Cross-generalization between a cocaine cue and two antihistamines
    D V Gauvin
    Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 3190 3000, USA
    Eur J Pharmacol 294:281-8. 1995
    ..Both diphenhydramine and doxylamine produced a partial generalization to the 10 mg/kg cocaine training stimulus. Drug mixtures produced complete cross-generalization with the training cue...
  37. pmc The importance of taking a history of over-the-counter medication use: a brief review and case illustration of "PRN" antihistamine dependence in a hospitalized adolescent
    BARBARA GRACIOUS
    Department of Psychiatry, Nationwide Children s Hospital The Ohio State University, Columbus, Ohio 43205, USA
    J Child Adolesc Psychopharmacol 20:521-4. 2010
    ..General strategies for combating OTC and prescription abuse are given...
  38. ncbi [Analgesic effects of H1 receptor antagonists in the rat model of formalin-induced pain]
    Hazem Adel Ashmawi
    Departamento de Medicina, Universidade Federal de Sao Carlos
    Rev Bras Anestesiol 59:461-70. 2009
    ..Some studies have demonstrated the analgesic effects of histamine receptor antagonists in the peripheral nervous system. It is not clear whether the local analgesic effect is class-specific or drug-specific...
  39. ncbi Histamine excites noradrenergic neurons in locus coeruleus in rats
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, Universitaetstrasse 1, 40225 Duesseldorf, Germany
    Neuropharmacology 49:129-34. 2005
    ..These findings underline the coordination between aminergic systems and suggest that the arousal induced by the histamine system could involve excitation of noradrenergic neurons in the locus coeruleus...
  40. ncbi Cross state-dependent retrieval between histamine and lithium
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran
    Physiol Behav 86:154-63. 2005
    ..In conclusion, histamine or lithium can induce state-dependent retrieval and a cross-StD exists between these drugs, which may be mediated through the inositol pathway...
  41. ncbi l-histidine induces state-dependent memory deficit in mice mediated by H(1) receptor
    Anna Carolyna Gianlorenço
    Laboratory of Neuroscience, Department of Physiotherapy, Federal University of Sao Carlos UFSCar, Sao Carlos, SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 35:91-5. 2011
    ..Thus, it can be suggested that LH induces emotional memory deficit and the treatment with chlorpheniramine was able to revert this effect, suggesting this action of LH was mediated by the H(1) receptor...
  42. ncbi The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers
    Fran Ridout
    HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, Surrey, United Kingdom
    Ann Allergy Asthma Immunol 90:404-10. 2003
    ..Genetic variations in cross-cultural metabolic capability may attenuate the lack of central nervous system effects of fexofenadine...
  43. ncbi Antihistamines in dermatology
    Malcolm W Greaves
    National Skin Centre, Singapore, Singapore
    Skin Pharmacol Physiol 18:220-9. 2005
    ..Two early low-sedation second-generation antihistamines caused arrhythmias in a small number of patients but these compounds have now been withdrawn. Generally, the second-generation H1 antihistamines are well tolerated...
  44. ncbi Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Miyagi, 980 8575, Sendai shi, Japan
    Life Sci 72:409-14. 2002
    ..b>Histamine H1 antagonists, or antihistamines, often prescribed for treatment of allergic disorders, sometimes induce sleepiness and ..
  45. ncbi Desloratadine: A new, nonsedating, oral antihistamine
    R S Geha
    Boston Children's Hospital and Harvard Medical School, Enders Building, Room 809, 300 Longwood Ave, Boston, MA 02115, USA
    J Allergy Clin Immunol 107:751-62. 2001
    ....
  46. ncbi P-glycoprotein limits the brain penetration of olopatadine hydrochloride, H1-receptor antagonist
    Nobuhito Mimura
    Pharmacokinetic Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Sunto gun, Shizuoka, Japan
    Drug Metab Pharmacokinet 23:106-14. 2008
    ..These results suggest that olopatadine is a substrate of P-gp, and that P-gp limits the brain penetration but dose not affect the plasma concentration of olopatadine...
  47. ncbi The noncompetitive antagonism of histamine H1 receptors expressed in Chinese hamster ovary cells by olopatadine hydrochloride: its potency and molecular mechanism
    Yuichi Matsumoto
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Japan
    Pharmacology 81:266-74. 2008
    ..The second extracellular loop in aminergic G-protein-coupled receptors contributes to ligand binding and therefore the noncompetitive property of olopatadine may be explained by the interaction with Glu 181...
  48. ncbi Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil
    G S Ratra
    Department of Toxicology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Toxicology 130:79-93. 1998
    ..Taken together, these data indicate that methapyrilene intoxication leads to mitochondrial disfunction and suggest a critical role for a loss of mitochondrial Ca2+ homeostasis in this model of hepatocyte death...
  49. ncbi Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper
    M K Church
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Germany
    Allergy 65:459-66. 2010
    ....
  50. ncbi An effective and more convenient drug regimen for prophylaxis against paclitaxel-associated hypersensitivity reactions
    M Markman
    Department of Hematology Medical Oncology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cancer Res Clin Oncol 125:427-9. 1999
    ....
  51. ncbi A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria
    Sarbjit Saini
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 128:567-73.e1. 2011
    ..Proof-of-concept studies with omalizumab in patients with chronic idiopathic urticaria (CIU) have shown significant decreases in mean urticaria activity scores (UASs)...
  52. ncbi Treatment of chronic autoimmune urticaria with omalizumab
    Allen P Kaplan
    National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC, USA
    J Allergy Clin Immunol 122:569-73. 2008
    ..If this occurs in CAU, cross-linking of IgE receptors by autoantibody would be less likely, reducing cell activation and urticaria/angioedema...
  53. ncbi Seizure-modifying potential of histamine H1 antagonists: a clinical observation
    Ippei Miyata
    Department of Pediatrics, Enshu General Hospital, Hamamatsu City, Shizuoka, Japan
    Pediatr Int 53:706-8. 2011
    ..The widely used histamine H(1) antagonists have a potential to induce seizures, although clinical evaluation is scarce except for a few case reports...
  54. pmc Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Br J Clin Pharmacol 61:16-26. 2006
    ..The purpose of the present study is to measure histamine H(1) receptor (H(1)R) occupancy due to olopatadine, a new second-generation antihistamine and to compare it with that of ketotifen...
  55. ncbi Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance
    H Takahashi
    Department of Dermatology, Asahikawa Medical College, Midorigaokahigashi, Asahikawa, Japan
    Clin Exp Dermatol 29:526-32. 2004
    ..Although olopatadine and cetirizine showed the strongest and most persistent suppression of histamine-induced wheal-and-flare response, olopatadine showed a considerable sedative effect with impaired psychomotor performance...
  56. ncbi Intranasal steroids and the risk of emergency department visits for asthma
    Robert J Adams
    Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, Australia
    J Allergy Clin Immunol 109:636-42. 2002
    ..In patients with asthma, treatment for associated conditions, such as rhinitis, is recommended. It is unknown whether this treatment can reduce the risk for emergency department (ED) visits for asthma...
  57. ncbi A comparison of two prophylactic regimens for hypersensitivity reactions to paclitaxel
    Janice S Kwon
    Division of Gynecologic Oncology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada
    Gynecol Oncol 84:420-5. 2002
    ....
  58. ncbi Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study
    M Kawashima
    Department of Dermatology, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    Br J Dermatol 148:1212-21. 2003
    ..The pruritus associated with atopic dermatitis is considered to be induced, in part, by histamine. Therefore, we thought that fexofenadine may be useful in the relief of pruritus associated with atopic dermatitis...
  59. ncbi Clinical pharmacology of H1-antihistamines in the skin
    F Estelle R Simons
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Canada
    J Allergy Clin Immunol 110:777-83. 2002
    ..The extent of the distribution of H(1)- antihistamines into the skin and H(1)-antihistamine activity in the skin are clinically relevant in the treatment of allergic skin disorders...
  60. ncbi Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Invest Dermatol 116:261-5. 2001
    ..In conclusion, both the histamine H1 and H2 receptors in the epidermis are involved in skin barrier function and the cutaneous condition of epidermal hyperplasia...
  61. ncbi Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines
    Stephen M Stahl
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    CNS Spectr 13:1027-38. 2008
    ..Selective H1 antagonism is emerging as a novel approach to the treatment of insomnia, without tolerance, weight gain, or the need for the restrictive prescription scheduling required of other hypnotics...
  62. ncbi S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
    C Mouta Carreira
    Center for Molecular Medicine, Maine Medical Center Research Institute, South Portland, Maine 04106, USA
    J Biol Chem 273:22224-31. 1998
    ....
  63. pmc Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine
    M Tagawa
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Br J Clin Pharmacol 52:501-9. 2001
    ....
  64. pmc Allergic rhinitis: evidence for impact on asthma
    Mike Thomas
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, UK
    BMC Pulm Med 6:S4. 2006
    ..This paper reviews the current evidence indicating that comorbid allergic rhinitis may have clinically relevant effects on asthma...
  65. ncbi Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic
    Joris C Verster
    Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University of Utrecht, Utrecht, The Netherlands
    Ann Allergy Asthma Immunol 92:294-303; quiz 303-5, 355. 2004
    ..All antihistamines are capable of crossing the blood-brain barrier and thus may cause sedation. Most antihistamine users are ambulatory patients and therefore presumably drive a car...
  66. ncbi Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor
    John C Anthes
    Schering Plough Research Institute, K15 1 1600, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 449:229-37. 2002
    ..The mechanism of desloratadine antagonism of the human histamine H(1) receptor may help to explain the high potency and 24-h duration of action observed in clinical studies...
  67. ncbi Update on ocular allergy treatment
    Leonard Bielory
    UMDNJ Asthma and Allergy Research Center, Department of Medicine, Pediatrics and Ophthalmology, New Jersey Medical School, Newark, New Jersey 07103, USA
    Expert Opin Pharmacother 3:541-53. 2002
    ..The increased interest in advancing ocular treatment will lead to the development of additional therapies, novel pharmacokinetic delivery systems and, thus, improved healthcare outcomes for patients with allergic conjunctivitis...
  68. ncbi Evaluation of efficacy and sedative profiles of H(1) antihistamines by large-scale surveillance using the visual analogue scale (VAS)
    Norimasa Izumi
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Allergol Int 57:257-63. 2008
    ..However, it is not easy to obtain these parameters. Here, we sought to evaluate the sedative properties of H(1) antihistamines by means of a large-scale surveillance at health insurance pharmacies...
  69. ncbi Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations
    S T Holgate
    Respiratory Cell and Molecular Biology, Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:1305-24. 2003
  70. ncbi Suppressive activity of fexofenadine hydrochloride on metalloproteinase production from nasal fibroblasts in vitro
    K Asano
    Department of Physiology, School of Medicine, Showa University, Tokyo 142 8555, Japan
    Clin Exp Allergy 34:1890-8. 2004
    ..Matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are the major proteolytic enzymes that induce airway remodelling. These enzymes are also important in the migration of inflammatory cells through basement membrane components...
  71. ncbi Antihistamines as analgesics
    R B Raffa
    Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Clin Pharm Ther 26:81-5. 2001
    ..However, it is possible that other mechanisms account for the analgesic effect...
  72. ncbi Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules
    Giorgio Ciprandi
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Allergy Clin Immunol 112:S78-82. 2003
    ....
  73. ncbi Advances in H1-antihistamines
    F Estelle R Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, and the Canadian Institutes of Health Research National Allergy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    N Engl J Med 351:2203-17. 2004
  74. ncbi Epinastine hydrochloride antagonism against interleukin-4-mediated T cell cytokine imbalance in vitro
    Ken Ichi Kanai
    Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Japan
    Int Arch Allergy Immunol 140:43-52. 2006
    ..The present study was undertaken to examine whether H1 receptor antagonists could modulate IL-4-mediated immune responses in vitro...
  75. ncbi Suppressive activity of fexofenadine hydrochloride on thymus- and activation-regulated chemokine production from human peripheral blood leukocytes in response to antigenic stimulation in vitro
    Kazuhito Asano
    Department of Physiology, School of Medicine, Showa University, Tokyo, Japan
    Int Arch Allergy Immunol 133:267-75. 2004
    ..The aim of this study is to examine the influence of fexofenadine hydrochloride (FEX), an H1-receptor antagonist, on TARC production from human peripheral blood leukocytes (PBL) using an in vitro cell culture technique...
  76. ncbi Potentiation of antimalarial drug action by chlorpheniramine against multidrug-resistant Plasmodium falciparum in vitro
    Sunan Nakornchai
    Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Parasitol Int 55:195-9. 2006
    ..falciparum K1 and T9/94. The results in this study indicate that antihistaminic drugs may be promising candidates for potentiating antimalarial drug action against drug resistant malarial parasites...
  77. pmc Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children
    A Sarashina
    Department of Drug Metabolism and Pharmacokinetics, Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co Ltd, Kawanishi 666 0193, Japan
    Br J Clin Pharmacol 59:43-53. 2005
    ..Our objective was to develop a population pharmacokinetic (PPK) model for epinastine, a histamine H(1) receptor antagonist, in adults and children and to obtain pharmacokinetic information to support dosing recommendations in children...
  78. ncbi Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations
    Hisham K Hamadeh
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:470-82. 2002
    ....
  79. ncbi Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis
    Alvaro Alonso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 66:572-5. 2006
    ....
  80. ncbi Histamine H1 receptor antagonism by cetirizine in isolated guinea pig tissues: influence of receptor reserve and dissociation kinetics
    Bernard Christophe
    UCB Pharma, Allergo Respiratory Pharmacology Department, Chemin du Foriest, Bâtiment R1, B 1420 Braine l Alleud, Belgium
    Eur J Pharmacol 470:87-94. 2003
    ..Their mixed antagonism profile observed in the trachea can be explained by the small receptor reserve present in this tissue compared to the ileum and their very slow dissociation rate from the histamine H(1) receptor...
  81. ncbi Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma
    M Aubier
    , H pital Bichat, Paris, France
    Allergy 56:35-42. 2001
    ..011 ). These data demonstrate a protective nasal effect of C against BHR measured 6 h after nasal allergen challenge in patients with AR. They suggest that C may be useful in patients with asthma associated with AR...
  82. ncbi Adenosine monophosphate bronchial provocation and the actions of asthma therapy
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Exp Allergy 33:287-94. 2003
  83. ncbi Dissociable effects of histamine H1 antagonists on reaction-time performance in rats
    A Blokland
    Maastricht Brain and Behaviour Institute, Faculty of Psychology, Section Neurocognition, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 70:427-36. 2001
    ..These findings suggest that the reaction-time task may be a sensitive tool for assessing effects of drugs on psychomotor function...
  84. ncbi The pharmacologic profile of desloratadine: a review
    B M Henz
    Department of Dermatology and Allergy, , Berlin, Germany
    Allergy 56:7-13. 2001
    ..Novel antiallergic and anti-inflammatory effects have also been noted with desloratadine, a fact which may be relevant to its clinical efficacy...
  85. ncbi Desloratadine demonstrates dose proportionality in healthy adults after single doses
    Samir Gupta
    Schering Plough Research Institute, Kenilworth, New Jersey 07033 0539, USA
    Clin Pharmacokinet 41:1-6. 2002
    ..To evaluate the dose proportionality and linearity and pharmacokinetic profile of desloratadine after single oral doses over the range of 5 to 20mg...
  86. ncbi Antihistamine antinociception is mediated by Gi-protein activation
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 109:811-8. 2002
    ..These results suggest an important role played by the Gi-protein pathway in the transduction mechanism involved in the enhancement of the pain threshold produced by H(1)-antihistamines...
  87. ncbi Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+
    A Gupta
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, India
    Indian J Exp Biol 42:481-5. 2004
    ..However, pretreatment with famotidine, a H2-receptor antagonist did not produce such a protective action. The results strongly suggest that histamine elicits its spermicidal action via H1-receptors present on sperm cells...
  88. ncbi [Oral second generation antihistamines in allergic rhinitis]
    H Riechelmann
    Univ HNO Klinik Ulm
    Laryngorhinootologie 84:30-41. 2005
    ..Histamine is a key mediator of the allergic immediate reaction. Antihistamines belong to the most frequently used treatment modalities in allergic rhinitis...
  89. ncbi Role of the histamine system in nefopam-induced antinociception in mice
    Philippe Girard
    Laboratoires Biocodex, Service de Pharmacologie, Zac de Mercières 60200 Compiègne, France
    Eur J Pharmacol 503:63-9. 2004
    ..In conclusion, nefopam analgesic activity is not mediated by histamine H1 or H2 receptors, but can be slightly modulated by histamine H3 receptors in mouse pain tests...
  90. ncbi Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor
    Ren Long Wu
    Schering Plough Research Institute, Schering Plough Corporation, Kenilworth, NJ 07033, USA
    Int Arch Allergy Immunol 135:313-8. 2004
    ..Certain H1 antihistamines have recently been shown to inhibit basal NF-kappaB activity by stabilizing the H1 receptor in an inactive state, a phenomenon called 'inverse agonism'...
  91. ncbi [Comparative activity of antihistamines on area under dose-response curve from histamine-induced wheal and flare responses in human skin]
    Rui qi Wang
    Department of Allergy, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:634-8. 2004
    ..To compare the activity of antihistamines by the index of area under dose-response curve (AUDRC) obtained from histamine-induced wheal and flare reactions...
  92. ncbi Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction
    Ashok Purohit
    INSERM U425 EA3771, Faculte de Pharmacie, Illkirch, and Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 93:562-7. 2004
    ..Histamine-induced wheal-and-flare studies are useful, objective tests for determining differences in the peripheral H1-receptor blockade activities of antihistamines...
  93. ncbi Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of histamine against stress ulcers in rats
    Artur Dembinski
    Department of Physiology, Jagiellonian University Medical School, 16 Grzegorzecka Street, Krakow 31 531, Poland
    Eur J Pharmacol 508:211-21. 2005
    ....
  94. ncbi Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate
    Susan Skeans
    Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
    Int Arch Allergy Immunol 137:37-44. 2005
    ..In this study, an allergic cynomolgus monkey model was used to characterize the condition of airway closure and assess the contribution of histamine H1 receptors to this response...
  95. ncbi Ginkgo biloba extract improves spatial memory in rats mainly but not exclusively via a histaminergic mechanism
    Yasuko Yamamoto
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8530, Japan
    Brain Res 1129:161-5. 2007
    ..From these findings, we concluded that the effects of GBE are mainly contributable to cholinergic activity and perhaps partly due to a histaminergic mechanism...
  96. ncbi Inhibition of the histamine-induced weal and flare response: a valid surrogate measure for antihistamine clinical efficacy?
    P Devillier
    Hopital Foch, Suresnes, France
    Clin Exp Allergy 37:400-14. 2007
    ....
  97. ncbi Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription
    Asish K Das
    Department of Molecular Pharmacology, Graduate School of Health Biosciences, The University of Tokushima, Japan
    J Pharmacol Sci 103:374-82. 2007
    ..This finding provides new insights into the therapeutic target of H1R antagonist in allergic diseases...
  98. ncbi Involvement of histamine released from mast cells in acute radiation dermatitis in mice
    Saiko Moriyasu
    Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
    J Pharmacol Sci 104:187-90. 2007
    ..These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators...
  99. ncbi Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms
    Andrea Strasser
    Department of Pharmacology and Toxicology, University of Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Pharmacol Exp Ther 324:60-71. 2008
    ....
  100. ncbi A comparative study of histamine activities on differentiation of osteoblasts and osteoclasts
    Yoshiko Ikawa
    J Toxicol Sci 32:555-64. 2007
    ..This observation is consistent with the traditionally recognized histamine action of bone resorption at the osteoclast site...
  101. ncbi Histamine-induced modulation of vascular tone in the isolated chicken basilar artery: a possible involvement of endothelium
    Tadatsune Okuno
    Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 147:339-44. 2008
    ..The main relaxing factor released from endothelial cells is probably nitric oxide. The resting vascular tone was modulated by spontaneously released nitric oxide, but not by prostaglandins or thromboxane A(2)...

Research Grants45

  1. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
  2. Naturally occurring T regulatory cells control airway hyperresponsiveness
    Erwin Gelfand; Fiscal Year: 2008
    ..abstract_text> ..
  3. Advances in Allergy, Asthma and Immunology
    Leonard Bielory; Fiscal Year: 2002
    ..Summary: This application will provide the catalyst for establishing an ongoing forum for the review and promotion of scientifically based research assessing the impact of CAM in allergy, asthma and immunology. ..
  4. HEAD CONTROL MECHANISMS DURING VOLUNTARY TRUNK MOVEMENTS
    Timothy Hain; Fiscal Year: 2002
    ..The comparison of intact and BVL populations will elucidate why some persons with BVL recover relatively high functional levels, and others do not. ..
  5. Optotrack Motion Analysis System
    Timothy Hain; Fiscal Year: 2005
    ..Motion analysis equipment is critical to all of our research faculty, and we have also recently added investigators to the department who need motion analysis capabilities. ..
  6. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  7. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  8. Autonomic dysregulation in primary insomnia
    Gary Richardson; Fiscal Year: 2005
    ..Finally, we will use a new measure of central CRF function, the DEX-sleep latency test, to test the hypothesis that central CRF tone is higher in patients with P1. ..
  9. Lymphocyte homing to the spleen
    MITCHELL GRAYSON; Fiscal Year: 2005
    ..Identification of mechanisms controlling entry of lymphocytes into the lymphoid compartment of the spleen will provide new targets for immunomodulatory drug therapy. ..
  10. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2005
    ..Studies will be done with freshly-dispersed bovine and cultured human airway smooth muscle cells. ..
  11. HRQL Impact of Chronic Conditions and Comorbidity Burden
    Patrick Sullivan; Fiscal Year: 2006
    ..S. [unreadable] [unreadable]..
  12. Pilot Study of DBS for Treatment-Refractory OCD
    Herbert Ward; Fiscal Year: 2006
    ..If shown effective, DBS might replace ablative neurosurgery, but should still be considered the intervention of last resort in the most profoundly ill and intractable cases of OCD. ..
  13. Biophysiological Mechanisms of 'Heightened Speech'
    Katherine Verdolini; Fiscal Year: 2007
    ..The primary dependent variable is quality of life in relation to voice, measured with the Voice Handicap Index. Secondary variables are aerodynamic, laryngeal, and vocal quality measures. [unreadable] [unreadable]..
  14. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  15. Role of Molecular Chaperones in hERG Processing
    Eckhard Ficker; Fiscal Year: 2008
    ..abstract_text> ..
  16. Automated Storage and Retrieval of Biological Systems
    Dan Roden; Fiscal Year: 2008
    ..Accordingly, this proposal requests a high end instrument to accomplish these goals, and to thereby enable a new era of Personalized Medicine. [unreadable] [unreadable] [unreadable] [unreadable]..
  17. OCULOMOTOR SYSTEM AND BODY POSTURAL MECHANISMS
    Bernard Cohen; Fiscal Year: 2009
    ..abstract_text> ..
  18. Genetic Epidemiology of Glioma International Consortium
    Melissa L Bondy; Fiscal Year: 2010
    ..This information has translational significance for brain tumor patients and their families, and will enable us to develop appropriate genetic screening and counseling approaches to reduce the incidence and mortality of this disease. ..
  19. MECHANISMS OF IGE REGULATION OF HUMAN LEUKOCYTES
    Sarbjit Saini; Fiscal Year: 2003
    ..The results of the planned studies will further define mechanisms of FcepsilonRI regulation on basophils and monocytes, and may lead to novel FcepsilonRI-based strategies for the treatment of allergic diseases. ..
  20. Identifying and Characterizing Histamine Transporters
    ANN STUART; Fiscal Year: 2003
    ..Successful cloning of a mammalian homologue would open the door to localizing this transporter within regions and cell types of the brain and determining whether it is present in other histamine-containing cells of the body. ..
  21. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003
    ..abstract_text> ..
  22. ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDREN
    Bruce Bender; Fiscal Year: 2004
    ..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
  23. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  24. Molecular Pathology of Cardic Arrhythmias
    Dan Roden; Fiscal Year: 2003
    ..abstract_text> ..
  25. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  26. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  27. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  28. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..Thus, patients who can tolerate higher doses of chemotherapy can be treated more efficiently, suffering from less side effects and potentially may have a better outcome. ..
  29. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  30. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved may help with the design of rational approaches to block the induction of immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  31. HEPATIC DRUG TRANSPORTERS IN DRUG DISPOSITION
    Dan Roden; Fiscal Year: 2006
    ..Moreover, variability in the extent of rifampin-mediated induction of the drug metabolizing enzyme, CYP3A, among subjects with variant OATP-C alleles, will also be tested. [unreadable] [unreadable]..
  32. IMMUNOTHERAPY FOR PATIENTS WITH PEANUT ANAPHYLAXIS
    ARVIL BURKS; Fiscal Year: 2003
    ..abstract_text> ..
  33. P GLYCOPROTEIN INDUCTION--KINETIC/DYNAMIC IMPLICATIONS
    GARY POLLACK; Fiscal Year: 2004
    ....
  34. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved in UV-induced immune suppression may help with the design of rational approaches to block immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  35. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  36. The Effectiveness of Treatment for Adult Periodontitis
    Philippe Hujoel; Fiscal Year: 2006
    ..This information can help determine in what area of periodontal research definitive clinical trials may offer the greatest contribution. ..
  37. Meningioma: Risk Factors and Quality of Life
    Melissa L Bondy; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningiomas. ..
  38. EXTRAMURAL RES FACILITIES CONSTR PROJ
    ARVIL BURKS; Fiscal Year: 2002
    ....
  39. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    ..If soybean IT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option. ..
  40. Immunotherapy for Peanut Allergy
    ARVIL BURKS; Fiscal Year: 2007
    ..The significance of this proposal is that if peanut SLIT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option for patients. ..
  41. MOLECULAR EPIDEMIOLOGY OF GLIOMAS
    Melissa Bondy; Fiscal Year: 2004
    ..no abstract available ..
  42. Determinants of Breast Cancer Survival
    Melissa Bondy; Fiscal Year: 2006
    ..abstract_text> ..
  43. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
    ..The focus of the studies presented here is to provide evidence to support the hypothesis that these drugs can act as novel agents to prevent skin cancer formation. ..
  44. THE ROLE OF MAST CELL STAT6 IN TH2 DIFFERENTIATION
    Melanie Sherman; Fiscal Year: 2004
    ....