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Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuriesGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
Invest Ophthalmol Vis Sci 49:762-71. 2008..In the present study, we characterized the time course and cellular localization of OPN expression in the rat retina after excitotoxic and ischemic injuries...
Prion protein attenuates excitotoxicity by inhibiting NMDA receptorsHouman Khosravani
Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
J Cell Biol 181:551-65. 2008..Thus, native PrP(C) mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits...
Differential activation of individual subunits in heteromeric kainate receptorsGeoffrey T Swanson
Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
Neuron 34:589-98. 2002....- Spontaneous voltage oscillations in striatal projection neurons in a rat corticostriatal sliceR Vergara
Department of Biophysics, , Mexico City 04510, Mexico
J Physiol 553:169-82. 2003..These data show that NMDA and L-type Ca2+ conductances of spiny neurons are capable of rendering them bistable. This may help to support prolonged depolarizations and voltage oscillations under certain conditions... - Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampusKenji Kawaguchi
Department of Neurology, University of Pittsburgh, PA 15260, USA
Brain Res 1050:130-7. 2005..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective... - Development of spontaneous recurrent seizures after kainate-induced status epilepticusPhilip A Williams
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
J Neurosci 29:2103-12. 2009.... - Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 miceZhiguo Chen
Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Karolinska University Hospital, Stockholm 14186, Sweden
J Neurobiol 62:207-18. 2005..In summary, KA administration results in an early microglial activation and a prolonged astrogliosis in C57BL/6 mice... - IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 miceZhiguo Chen
Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
Neurobiol Dis 17:171-8. 2004..In summary, this study indicates that IL-12 may play a critical role in excitotoxin-induced brain injury... - Metabotropic glutamate receptors drive the endocannabinoid system in hippocampusN Varma
Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 21:RC188. 2001..We conclude that group I mGluR-induced enhancement of DSI, and suppression of IPSCs, is actually mediated by endocannabinoids. This surprising result opens up new approaches to the investigation of cannabinoid actions in the brain... - Pharmacological agents acting at subtypes of metabotropic glutamate receptorsD D Schoepp
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Neuropharmacology 38:1431-76. 1999..This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents... - The course of cellular alterations associated with the development of spontaneous seizures after status epilepticusF Edward Dudek
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523, USA
Prog Brain Res 135:53-65. 2002.... - Role of glutamate autoreceptors at hippocampal mossy fiber synapsesHyung Bae Kwon
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neuron 60:1082-94. 2008..Thus, negative feedback via presynaptic mGluRs is the dominant mode of glutamatergic autoregulation at the mf-CA3 synapse... - Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1Joyce Wondolowski
Department of Behavioral Neuroscience and Neuroscience Graduate Program, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Neurosci 29:563-74. 2009..GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms... - Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insultsAngela L Lee
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
J Neurochem 86:1079-88. 2003..This difference raises the possibility that the means by which these channel subtypes protect may differ. With further development, potassium channel vectors may be an effective pre-emptive strategy against necrotic insults... - Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cellsG T Swanson
Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
J Physiol 513:639-46. 1998..At synapses such mechanisms could regulate the frequency- response relationship of synaptic kainate receptors by altering their rate of entry into and recovery from desensitization... - Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depressionWade Morishita
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
Neuropharmacology 52:71-6. 2007..These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus... - Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neuronsMala M Shah
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Neuron 44:495-508. 2004..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks... - Pharmacology and functions of metabotropic glutamate receptorsP J Conn
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Annu Rev Pharmacol Toxicol 37:205-37. 1997..These findings have exciting implications for drug development and suggest that the mGluRs provide a novel target for development of therepeutic agents that could have a significant impact on neuropharmacology... - The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activityS A Henry
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
Neuropharmacology 43:1199-209. 2002..The effects of MPEP on the response to PCP may reflect the cooperation and co-localization of NMDA and mGlu5 receptors... - Group III metabotropic glutamate receptors and exocytosed protons inhibit L-type calcium currents in cones but not in rodsNobutake Hosoi
Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Tokyo 113-0033, Japan
J Neurosci 25:4062-72. 2005..Selective modulation of ICa in cones may help broaden the dynamic range of synaptic transfer by controlling the amount of transmitter release from cones... - Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cellsZare Melyan
Centre for Neuroscience, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
Neuron 34:107-14. 2002..These data suggest how KARs, putatively containing GluR6, directly increase excitability of CA1 pyramidal cells and help explain the propensity for seizure activity following KAR activation... - Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retinaA Laabich
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 40202, USA
Brain Res Mol Brain Res 91:34-42. 2001..The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina... - Modulation of a voltage-gated calcium channel linked to activation of glutamate receptors and calcium-induced calcium release in the catfish retinaC L Linn
Western Michigan University, Department of Biological Sciences, 1903 W Michigan Avenue, Kalamazoo, MI 49008, USA
J Physiol 535:47-63. 2001..Inhibition of this calcium current directly or indirectly involves calmodulin and CaM kinase II and represents a possible mechanism used by horizontal cells to affect response properties of these cells... - Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathwayJon Nilsen
Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Brain Res 930:216-34. 2002..These data provide potential mechanisms to explain the cognitive enhancing and neuroprotective effects exerted by ERT... - Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsyBret N Smith
Department of Anatomy and Neurobiology, Program in Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA
J Neurophysiol 87:1655-8. 2002..These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus... - Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampusArek Szklarczyk
Laboratory of Molecular Neurobiology, Nencki Institute, PL 02 093 Warsaw, Poland
J Neurosci 22:920-30. 2002..This unique spatiotemporal pattern of MMP-9 expression suggests its involvement in activity-dependent remodeling of dendritic architecture with possible effects on synaptic physiology... - Kainic acid-mediated excitotoxicity as a model for neurodegenerationQun Wang
Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
Mol Neurobiol 31:3-16. 2005..The focus of this review is to summarize studies demonstrating KA-induced excitotoxicity in the central nervous system and possible intervention by anti-oxidants... - Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matterS Li
Ottawa Health Research Institute, Division of Neuroscience, Ottawa Hospital, Civic Campus, University of Ottawa, 725 Parkdale Avenue, Ottawa, ON, Canada K1Y 4K9
Neuroscience 107:675-83. 2001..This mechanism likely plays an important role during ischemic and traumatic white matter injury, where collapse of transmembrane Na(+) and K(+) gradients occurs... - Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinaseG Fuller
Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
Brain Res Mol Brain Res 89:126-32. 2001..This provides evidence for a novel pathway linking striatal kainate receptors to ERK activation via PI3 kinase and MEK... - Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxiaAgnieszka Nadlewska
Department of Pharmacology, Medical Academy, , Poland
Pol J Pharmacol 54:11-8. 2002..In rats subjected to hypoxia, (S)-3,5-DHPG, the agonist of I mGluRs, improved consolidation and retrieval and exhibited anxiolytic activity in dose-dependent manner... - Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonistsDaniel C Javitt
Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
Neuropsychopharmacology 29:300-7. 2004..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia... - Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammationDongni Yang
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
Pain 106:411-7. 2003.... - Fragmented DNA transport in dendrites of retinal neurons during apoptotic cell deathAkira Hara
Department of Tumor Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
Brain Res 1007:183-7. 2004..The transport of fragmented DNA, but not fragmentation per se, was completely inhibited by the co-administration of vincristine... - Comparative behavioral changes between male and female postpubertal rats following neonatal excitotoxic lesions of the ventral hippocampusAdriana B Silva-Gómez
Escuela Superior de Medicina del IPN, D F, Mexico
Brain Res 973:285-92. 2003.... - Activation of Ih is necessary for patterning of mGluR and mAChR induced network activity in the hippocampal CA3 regionS R Cobb
Division of Neuroscience and Biomedical Systems, University of Glasgow, Glasgow, G12 8QQ, UK
Neuropharmacology 44:293-303. 2003..These data support the idea that the I(h) pacemaker current is important in the generation of patterned neuronal activities in the hippocampus... - Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depressionLingfei Hou
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 24:6352-61. 2004..Together, our findings indicate that activation of the PI3K-Akt-mTOR signaling cascade is required for mGluR-LTD and suggest that this pathway may couple group I mGluRs to translation initiation in hippocampal area CA1... - Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depressionPeter V Massey
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 24:7821-8. 2004..Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex... - Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated ratsW Yuan
Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa 33612 4799, USA
Neuroscience 114:1091-101. 2002..The observed ADAMTS-induced cleavage of brevican in the dentate outer molecular layer is closely associated with diminished synaptic density, and may, therefore, contribute to synaptic loss and/or reorganization in this region... - Differential properties of dentate gyrus and CA1 neural precursorsH Becq
INMED/INSERM U29, Marseille, France
J Neurobiol 62:243-61. 2005..These results suggest that CA1 precursors are more stem-cell-like than granule cell precursors, which may represent a more restricted precursor cell... - Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptorsPatrick J Mueller
Department of Biomedical Sciences, Dalton Cardiovascular Research Center, 134 Research Park, University of Missouri, Columbia, MO 65211-3300, USA
Am J Physiol Regul Integr Comp Physiol 289:R198-208. 2005..Thus we conclude that responses to L-AP4 in the NTS are mediated by an interaction between group III mGluRs and NMDA receptors. Finally, we also caution that nonselective actions of L-AP4 should be considered in future studies... - Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociceptionDongni Yang
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 22:6388-93. 2002.... - (S)-3,5-DHPG: a reviewKonstanty Wiśniewski
Department of Pharmacology, Medical Academy, 15 222 Bialystok, Mickiewicza 2c, Poland
CNS Drug Rev 8:101-16. 2002..S)-3,5-DHPG may be useful as a cognitive enhancing agent in memory impairment associated with ischemia or hypoxia. Recent investigations suggested possible beneficial effects of (S)-3,5-DHPG in Alzheimer's disease... - Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainateJerome Jourquin
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, CNRS FRE 2533 IFR Jean Roche Université de la Méditerranée Faculté de Médecine de Marseille, 27 Bd Jean Moulin 13385, Marseille Cedex 05, France
Eur J Neurosci 18:1507-17. 2003.... - Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioningS Hatazaki
Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
Neuroscience 150:467-77. 2007..The present study defines a paradigm for inducing epileptic preconditioning in mice and first insight into the global transcriptome of the seizure-damage refractory brain... - Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleusHelen L Alderson
School of Psychology, St Andrews University, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
Eur J Neurosci 23:2169-75. 2006..The resulting change in nicotine self-administration behaviour was hypothesized to reflect either a reduction in intrinsic nicotine reward value, or enhancement of associative incentive salience... - GABAergic network activation of glial cells underlies hippocampal heterosynaptic depressionAlexandre Serrano
Centre de Recherche en Sciences Neurologiques, , , Succursale Centre-Ville, , , H3C 3J7, Canada
J Neurosci 26:5370-82. 2006..Thus, glial and neuronal networks are functionally associated during the genesis of heterosynaptic plasticity at mammalian central excitatory synapses... - Alcohol blocks TNFalpha but not other cytokine-mediated neuroprotection to NMDAL C Gahring
Salt Lake City Veterans Administration Medical Center, Department of Medicine, University of Utah School of Medicine, 84112 5330, USA
Alcohol Clin Exp Res 23:1571-9. 1999..We have investigated the effects of ethanol/alcohol (ETOH) on the pro-inflammatory CNS cytokine network that mediates neuroprotection to an excitotoxic challenge with the glutamate receptor agonist N-methyl-D-aspartic acid (NMDA)... - Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2K A Kelley
Neuroinflammation Research Laboratories, Department of Psychiatry, Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York, USA
Am J Pathol 155:995-1004. 1999..This model system will allow the systematic examination of the role of COX-2 in mechanisms of neurodegeneration that involve excitatory amino acid pathways... - mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneuronesLisa Topolnik
, Centre de Recherche en Sciences Neurologiques, , Case Postale 6128, Succursale Centre-Ville, , QC, Canada H3C 3J7
J Physiol 575:115-31. 2006..Thus, our findings uncover a novel molecular mechanism of interneurone-specific Ca2+ signalling, critical in regulating synaptic excitability in hippocampal networks... - The role of NMDAR subtypes and charge transfer during hippocampal LTP inductionSven Berberich
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
Neuropharmacology 52:77-86. 2007..Thus, at least for LFS pairing, the amount of charge transfer, and thus Ca2+ influx, during LTP induction is a factor more critical than the participation of a particular NMDAR subtype... - The spatiotemporal pattern of somal and axonal pathology after perikaryal excitotoxic injury to retinal ganglion cells: a histological and morphometric studyS K Saggu
Department of Ophthalmology and Visual Sciences, The University of Adelaide, SA 5000, Australia
Exp Neurol 211:52-8. 2008..To describe the spatiotemporal pattern of somal and axonal pathologic changes after perikaryal excitotoxic injury to retinal ganglion cells in-vivo... - NR2B-containing receptors mediate cross talk among hippocampal synapsesAnnalisa Scimemi
Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 24:4767-77. 2004..These NMDAR isoforms thus play complementary roles in sensing global and local glutamate signals, respectively... - Differential roles for NMDA and non-NMDA receptor subtypes in baroreceptor afferent integration in the nucleus of the solitary tract of the ratJ Zhang
Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX 78284 7764, USA
J Physiol 511:733-45. 1998..Finally, the ADN-evoked discharge of some MSNs and PSNs is not attenuated by ionotropic EAA antagonists, suggesting that another receptor or transmitter system may mediate synaptic excitation in these neurones... - Enhanced taurine release in cultured cerebellar granule cells in cell-damaging conditionsP Saransaari
Tampere Brain Research Center, University of Tampere Medical School, Finland
Amino Acids 17:323-34. 1999..The prolonged taurine release seen in both normoxia and cell-damaging conditions may be of importance in maintaining homeostasis in the cerebellum and reducing excitability for a longer period than other neuroprotective mechanisms... - NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytesUlyana Lalo
Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
J Neurosci 26:2673-83. 2006..We conclude that cortical astrocytes express functional NMDA receptors that are devoid of Mg2+ block, and these receptors are involved in neuronal-glial signal transmission... - Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell deathJ van Beek
European Institute for Peptide Research IFRMP 23, INSERM U519, Rouen, France
Neuroreport 12:289-93. 2001..These observations suggest that C3a is involved in excitotoxicity-mediated neuronal death through astrocyte stimulation and extend its role beyond immune functions... - A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slicesA J Doherty
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD
Br J Pharmacol 131:239-44. 2000..6. These results further indicate that mGlu receptor-mediated potentiation of NMDA responses is not essential for the induction of LTP... - The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentialsDe Maw Chuang
Molecular Neurobiology Section, Biological Psychiatry Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1363, USA
Ann N Y Acad Sci 1053:195-204. 2005..Thus, lithium and valproate are potential drugs for treating some forms of neurodegenerative diseases... - Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognitionChantal Schlumberger
Department of In Vivo Pharmacology, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany
Behav Pharmacol 20:56-66. 2009..In conclusion, LY354740 was effective in models for anxiety and positive symptoms of schizophrenia but not in models for sensorimotor gating and cognitive impairment... - Spontaneous recurrent network activity in organotypic rat hippocampal slicesMajid H Mohajerani
Neuroscience Program, International School for Advanced Studies, Via Beirut 2-4, 34014 Trieste, Italy
Eur J Neurosci 22:107-18. 2005..This was in line with the transient bicuculline-induced block of GDPs and with the isoguvacine-induced increase of GDP frequency... - NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153Maiko Awai
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
J Neurochem 96:43-52. 2006..In conclusion, CHOP is induced in mouse retina by NMDA treatment, and CHOP/ mice are more resistant to NMDA-induced retinal damage, suggesting that CHOP plays an important role in NMDA-induced retinal cell death... - Modulation of the glycine response by Ca2+-permeable AMPA receptors in rat spinal neuronesT L Xu
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
J Physiol 514:701-11. 1999..This interaction may provide a new postsynaptic mechanism for control of inhibitory synaptic signalling and represent one of the important regulatory mechanisms of spinal nociception... - Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic densityNatasha Lozovaya
Bogomoletz Institute of Physiology, Kiev, Ukraine
Brain Res 1011:195-205. 2004..Our results indicate that extrasynaptic and PSD membranes of CA1 neurons form separate compartments differing in the mechanisms and efficiency of external Glu processing: the protection of PSD markedly prevails... - Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neuronsV V Grigorev
Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia
Bull Exp Biol Med 136:474-7. 2003..It was hypothesized that the differences in the effects of memantine and dimebon are determined by their interaction with different sites of NMDA-receptors... - Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currentsMorten Blaabjerg
Anatomy and Neurobiology, University of Southern Denmark-Odense, Denmark
Exp Neurol 183:573-80. 2003..We conclude that neuroprotection induced by activation of group-I-mGluRs involve mGluR1 and is associated with decreased NMDA-stimulated currents... - Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entryLaxmikant S Deshpande
Department of Neurology, Virginia Commonwealth University, Richmond, VA 23298, USA
Eur J Pharmacol 583:73-83. 2008.... - Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2BK Ulrich Bayer
Department of Pharmacology, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 26:1164-74. 2006..This activity-dependent incorporation of CaMKII into postsynaptic sites may play a role in maturation and plasticity of synapses... - Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attention-deficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat)Fleur Margaret Howells
Neuroscience Laboratory, Division of Physiology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 South Africa
Brain Res 1200:107-15. 2008..The present findings reveal a novel NMDA component that influences AMPA receptor-mediated regulation of norepinephrine release in SHR hippocampus... - Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injectionLavina J Faleiro
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
Neuropsychopharmacology 29:2115-25. 2004..We conclude that amphetamine induces rapid changes in synaptic AMPAR/NMDAR ratios, suggesting that potentiation of glutamatergic synapses is a relatively early event in the series of neuroadaptations in response to drugs of abuse... - AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivoJuan Carlos Corona
Departamento de Neurociencias, , , , D. F,
J Neurochem 89:988-97. 2004.... - Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptorsYu Wei Liu
Wuhan Institute of Neuroscience and Drug Research, Jianghan University, Wuhan 430056, PR China
Biochem Biophys Res Commun 369:1007-11. 2008..These results suggest that bis(7)-tacrine is more potent than memantine against glutamate-induced neurotoxicity by selectively inhibiting NMDA-activated current... - Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channelsPatrick J Mulholland
Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 28:8801-9. 2008..These data support a novel mechanism for glutamate transporters in regulation of neuronal excitability and plasticity through extrasynaptic NMDA receptor modulation of Kv2.1 channels... - [Apoptosis and its receptor selective pathways during neurotoxic action of glutamate]A A Evstratova
Ross Fiziol Zh Im I M Sechenova 94:380-93. 2008..The AMPA/kainate receptor mediated apoptosis includes the caspase-3-dependent mechanism... - Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamateTzu Hung Lin
Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan
Eur J Pharmacol 589:37-44. 2008..Activation of both AMPA and NMDA receptors regulates the maturation of osteoblasts. NMDA but not AMPA affects receptor for activation of NF-kappaB ligand (RANKL)-induced osteoclastogenesis... - Tunicamycin decreases the probability of single-channel openings for N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptorsKeishi Maruo
Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
Neuroreport 17:313-7. 2006.... - Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neuronsTheresa A Lusardi
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Neurotrauma 21:61-72. 2004.... - Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticityRui Li
Department of Medical Biophysics, Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
BMC Neurosci 8:55. 2007..For comparison, we also examined other forms of plasticity, including a "slow LTD" induced by 0.1 Hz stimulation under low Mg2+ conditions as well as long-term potentiation (LTP)... - Physiological role for casein kinase 1 in glutamatergic synaptic transmissionKarima Chergui
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
J Neurosci 25:6601-9. 2005..These results provide the first evidence for a role of CK1 in the regulation of synaptic transmission in the brain... - Mitochondrial superoxide production and MnSOD activity after exposure to agonist and antagonists of ionotropic glutamate receptors in hippocampusLidija Radenovic
Department of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Serbia and Montenegro
Ann N Y Acad Sci 1048:363-5. 2005..Our findings suggest that NMDA and AMPA/kainate receptors are differentially involved in superoxide production, and they also impose different neuroprotective effects on the induction of MnSOD activity in hippocampus... - Rap2-JNK removes synaptic AMPA receptors during depotentiationYinghua Zhu
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Neuron 46:905-16. 2005.... - Long-term potentiation of silent synapses in substantia gelatinosa neuronsSung Jun Jung
Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul 110-799, South Korea
Neuroreport 16:961-5. 2005.... - A noncanonical release of GABA and glutamate modulates neuronal migrationJean Bernard Manent
Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale U29, Campus de Luminy BP13, 13273 Marseille, France
J Neurosci 25:4755-65. 2005..We conclude that GABA and, to a lesser degree, glutamate released in a SNARE-independent mechanism exert a paracrine action on neuronal migration... - The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neuronsXueying Jiang
Department of Neurology and Division of Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Neurochem 94:713-22. 2005.... - In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampusKiyokazu Ogita
Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
Neuropharmacology 48:810-21. 2005..Taken together, in vivo activation of NMDA receptors is capable of protecting against kainate-induced neuronal damage through blockade of DNA fragmentation induced by deoxyribonuclease II in the murine hippocampus... - Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptorsPaul M Lea
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057-2197, USA
Br J Pharmacol 145:527-34. 2005..5 Combined, these studies support the conclusion that MTEP has greater mGluR5 selectivity than MPEP, and that neuroprotection provided by either antagonist in neuronal cultures does not reflect inhibition of mGluR5 receptors... - Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axonsLuz M Suárez
Servicio de Neurobiología Investigación, Hospital Ramon y Cajal, Madrid 28034, Spain
Eur J Neurosci 24:405-18. 2006..These results reveal that presynaptic NMDARs have unique properties that mediate the facilitation of axon excitability... - Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophreniaKuei Yuan Tseng
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
Biol Psychiatry 62:730-8. 2007.... - D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neuronsXiang-Qun Gong
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
Br J Pharmacol 145:449-59. 2005..The prevalence of D-aspartate in the brain suggests a possible role of D-aspartate in modulating AMPAR-mediated fast excitatory synaptic transmission... - Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigationsL G Magazanik
I M Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia
Neurosci Behav Physiol 37:277-84. 2007..The differences in the mechanisms of action on AMPA and NMDA receptors may explain the ambiguous nature of the effects of the glutamate channel blocker in experimental therapy... - Glutamate exocytosis from astrocytes controls synaptic strengthPascal Jourdain
Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
Nat Neurosci 10:331-9. 2007..Thus, we provide the first combined functional and ultrastructural evidence for a physiological control of synaptic activity via exocytosis of glutamate from astrocytes... - Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice culturesKatherine J Smith
University of Kentucky, Department of Psychology, B363 Biomedical and Biological Sciences Building, Lexington, KY 40536 0509, USA
Brain Res 1157:74-80. 2007..These findings indicate that the pharmacological effects of short-term METH exposure involve inhibition of NMDA receptor-mediated neuronal signaling, not reflective of direct channel inhibition at an MK-801-sensitive site... - D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neuronsXiang Qun Gong
Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada
Can J Physiol Pharmacol 85:546-55. 2007..More importantly, vesicular-released endogenous D-serine from astrocytes could potentially modulate AMPA receptors in synaptic transmission in hippocampus... - Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampusJulie V Selkirk
Neurosciences Department, Neurocrine Biosciences Inc, 12970 El Camino Real, San Diego, CA 92130, USA
Eur J Neurosci 21:3217-28. 2005.... - Non-ionotropic cross-talk between AMPA and NMDA receptors in rodent hippocampal neuronesDonglin Bai
Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Institute of Medical Science, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
J Physiol 543:23-33. 2002..The AMPA-NMDA cross-inhibition also occurred in evoked synaptic current in CA1 neurones from intact mouse hippocampal slices. This cross-talk may play a role in preventing overexcitation during bursting activities in the hippocampus... - Dorsal hippocampus and classical fear conditioning to tone and context in rats: effects of local NMDA-receptor blockade and stimulationTobias Bast
Behavioral Neurobiology Laboratory, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
Hippocampus 13:657-75. 2003..The role of the dorsal hippocampus and local NMDA receptor-mediated processes in fear conditioning to tone and context is discussed in comparison with ventral hippocampal processes... - Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effectWan-Chen Lo
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan, ROC
Eur J Pharmacol 454:39-45. 2002..They also suggested that CO and excitatory amino acids may interact in the nucleus tractus solitarii of rats... - Chronic multichannel recordings from organotypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by non-competitive NMDA antagonistsKen Shimono
Tensor Biosciences, 101 Theory Dr, Suite 250, Irvine, CA 92612, USA
J Neurosci Methods 120:193-202. 2002..Thus, this new technology might provide a new and powerful method to study the chronic effects of drugs or other experimental manipulations in an in vitro preparation... - Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neuronsR Griffiths
Neurochemistry Group, School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
J Neurosci Res 48:533-42. 1997.... - Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal ratsP Wang
Department of Pediatrics, University of Michigan, Ann Arbor 48109 0646, USA
Neuroscience 88:585-97. 1999..These data support the hypothesis that locally released Tat could exert neurotoxic effects, mediated by N-methyl-D-aspartate receptor activation, in vivo in the immature brain... - Expression and regulation of Na pump isoforms in cultured cerebellar granule cellsT M Soga
Department of Biochemistry I, Yokohama City University School of Medicine, Yokohama, Japan
Neuroreport 12:829-32. 2001..The glutamate effects were mainly mediated by non-NMDA receptors. These results suggest that alpha1 isoform and alpha3/alpha2 isoforms are functionally important under basal conditions and after neuronal excitation, respectively... - The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice culturesM Blaabjerg
Anatomy and Neurobiology, Institute of Medical Biology, SDU-Odense University, , DK-5000 C, Odense, Denmark
Brain Res 898:91-104. 2001....
Research Grants
- INTERLEUKIN-1 AND PERINATAL BRAIN INJURYFaye Silverstein; Fiscal Year: 1999....
- NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINEKenneth Johnson; Fiscal Year: 1993..3. The potential role of nitric oxide (NO) in the effects of glutamate and excitatory amino acid agonists on transmitter release will be determined...
- D-Cycloserine Facilitation of Cocaine-Cue ExtinctionKathleen Brady; Fiscal Year: 2009..New treatments are needed for cocaine dependence. Cocaine-related environmental cues are likely to be involved in relapse. In this study, an innovative pharmacologic approach to decreasing the response to cocaine cues will be tested. ..
- D-Cycloserine Facilitation of Cocaine-Cue ExtinctionKATHLEEN THERESA BRADY; Fiscal Year: 2010..New treatments are needed for cocaine dependence. Cocaine-related environmental cues are likely to be involved in relapse. In this study, an innovative pharmacologic approach to decreasing the response to cocaine cues will be tested. ..
- Basic and Clinical Studies of Noise-Induced and Age-Related Hearing LossSHARON KUJAWA; Fiscal Year: 2010..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
- Basic and Clinical Studies of Noise-Induced and Age-Related Hearing LossSHARON KUJAWA; Fiscal Year: 2009..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
- Basic and Clinical Studies of Noise-Induced and Age-Related Hearing LossSHARON KUJAWA; Fiscal Year: 2009..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
- VISION AND INTRARETINAL POTENTIALSDWIGHT BURKHARDT; Fiscal Year: 1993..Other experiments will analyze membrane potential, temporal resolution, voltage-sensitive mechanisms and pigment regeneration during dark adaptation...
- HEROIN AIDS ENCEPHALOPATHY--NEUROPATHOGENESIS MECHANISMSMadhavan Nair; Fiscal Year: 2005..We further demonstrated that in vivo stereotaxic injection of HIV proteins plus excitatory amino acid agonists into the dorsal hippocampus of neonatal rat brains causes both gross and microscopic neuropathology...
- Use of Novel Cox-2 Inhibitors in Neurological DisordersSTANLEY BELL; Fiscal Year: 2006....
- IONIC MECHANISM OF EXCITATORY AMINO ACIDSJOHN HABLITZ; Fiscal Year: 1993..preparations by examining intracellularly recorded EPSPs and responses to iontophoretically applied excitatory amino acid agonists. Studies on cultured rat neocortical neurons will determine the mechanism underlying the biphasic ..
- AIDS encephalopathy and HIV disease: role of opioidsMadhavan Nair; Fiscal Year: 2006..We further demonstrated that in vivo stereotaxic injection of HIV proteins plus excitatory amino acid agonists into the dorsal hippocampus of neonatal rat brains causes both gross and microscopic neuropathology...
- NMDA RECEPTOR AND BEHAVIORAL TOXICITY OF LEADDeborah Cory Slechta; Fiscal Year: 1993....
- DOPAMINE SYSTEM INTERACTIONS AND SCHIZOPHRENIAARIEL DEUTCH; Fiscal Year: 2004..of the NAS and PFC DA innervations to agents that evoke DA release (KC1 and amphetamine) and to excitatory amino acid agonists (NMDA and AMPA)...
- Mechanisms of Secondary Damage after Spinal Cord InjuryJACQUELINE BRESNAHAN; Fiscal Year: 2009..These studies should provide evidence to test whether this novel interaction between a cytokine and a neurotransmitter may be involved in the exacerbation of secondary injury following SCI. If so, it may be a new target for therapies. ..