excitatory amino acid agonists

Summary

Summary: Drugs that bind to and activate excitatory amino acid receptors.

Top Publications

  1. ncbi Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
  2. ncbi Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 125:785-99. 2006
  3. ncbi Mixed inhibitory synaptic balance correlates with glutamatergic synaptic phenotype in cerebellar unipolar brush cells
    Charly V Rousseau
    Inhibitory Transmission Team, Institut de Biologie de l ENS, IBENS, INSERM, U1024, CNRS, UMR 8197, Paris, F 75005 France
    J Neurosci 32:4632-44. 2012
  4. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
  5. ncbi Effects of D-cycloserine on extinction of conditioned freezing
    Lana Ledgerwood
    School of Psychology, University of New South Wales, Sydney, Australia
    Behav Neurosci 117:341-9. 2003
  6. ncbi STAT3 activation protects retinal ganglion cell layer neurons in response to stress
    Chun Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Eye Res 86:991-7. 2008
  7. ncbi Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7
    G Sansig
    Nervous System Department, Novartis Pharma AG, CH 4002 Basel, Switzerland
    J Neurosci 21:8734-45. 2001
  8. ncbi Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats
    P S Buckmaster
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    J Comp Neurol 385:385-404. 1997
  9. pmc Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neurobiol Dis 25:360-6. 2007
  10. ncbi Pharmacology and functions of metabotropic glutamate receptors
    P J Conn
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 37:205-37. 1997

Research Grants

  1. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
  2. EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITRO
    JOHN DELFS; Fiscal Year: 1992
  3. HYPOTHERMIA AND TRAUMA
    Larry Jenkins; Fiscal Year: 2000
  4. HEROIN AIDS ENCEPHALOPATHY--NEUROPATHOGENESIS MECHANISMS
    Madhavan Nair; Fiscal Year: 2005
  5. NEURAL BASIS OF AUDIO-VOCAL INTEGRATION
    Walter Metzner; Fiscal Year: 1999
  6. QUISQUALATE SENSITIZATION AND NEUROTOXICITY
    JAMES KOERNER; Fiscal Year: 1999
  7. Use of Novel Cox-2 Inhibitors in Neurological Disorders
    STANLEY BELL; Fiscal Year: 2006
  8. AIDS encephalopathy and HIV disease: role of opioids
    Madhavan Nair; Fiscal Year: 2006
  9. PERINATAL HIV INFECTIONS--PREVENTION OF CNS PATHOLOGY
    Stanley Schwartz; Fiscal Year: 1999
  10. MECHANISMS OF LEAD NEUROTOXICITY
    David Carpenter; Fiscal Year: 1992

Detail Information

Publications254 found, 100 shown here

  1. ncbi Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
    ..The focus of this review is to summarize studies demonstrating KA-induced excitotoxicity in the central nervous system and possible intervention by anti-oxidants...
  2. ncbi Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 125:785-99. 2006
    ..These results indicate that NMDAR signaling during miniature synaptic transmission serves to stabilize synaptic function through active suppression of dendritic protein synthesis...
  3. ncbi Mixed inhibitory synaptic balance correlates with glutamatergic synaptic phenotype in cerebellar unipolar brush cells
    Charly V Rousseau
    Inhibitory Transmission Team, Institut de Biologie de l ENS, IBENS, INSERM, U1024, CNRS, UMR 8197, Paris, F 75005 France
    J Neurosci 32:4632-44. 2012
    ..We propose that slow glycinergic IPSCs may provide an inhibitory tone, setting the gain of the MF to UBC relay, whereas large and fast GABAergic IPSCs may in addition control spike timing in mGluRII-negative UBCs...
  4. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    ..In this instance, subunit differences cannot account for the dichotomous nature of NMDA receptor signaling...
  5. ncbi Effects of D-cycloserine on extinction of conditioned freezing
    Lana Ledgerwood
    School of Psychology, University of New South Wales, Sydney, Australia
    Behav Neurosci 117:341-9. 2003
    ..These results suggest that DCS facilitates extinction of conditioned freezing by acting on consolidation processes partly mediated by the basolateral amygdala...
  6. ncbi STAT3 activation protects retinal ganglion cell layer neurons in response to stress
    Chun Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Eye Res 86:991-7. 2008
    ..Our results suggest that persistent activation of STAT3 by neurotrophic factors provides strong neuroprotection and will be an effective strategy in a number of chronic retinal diseases...
  7. ncbi Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7
    G Sansig
    Nervous System Department, Novartis Pharma AG, CH 4002 Basel, Switzerland
    J Neurosci 21:8734-45. 2001
    ..Our findings suggest that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs...
  8. ncbi Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats
    P S Buckmaster
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    J Comp Neurol 385:385-404. 1997
    ....
  9. pmc Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neurobiol Dis 25:360-6. 2007
    ..The results provide further support for the hypothesis that BMAA plays a role in neurodegenerative diseases...
  10. ncbi Pharmacology and functions of metabotropic glutamate receptors
    P J Conn
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 37:205-37. 1997
    ..These findings have exciting implications for drug development and suggest that the mGluRs provide a novel target for development of therepeutic agents that could have a significant impact on neuropharmacology...
  11. pmc Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
    J Cell Biol 181:551-65. 2008
    ..Thus, native PrP(C) mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits...
  12. ncbi Spontaneous recurrent network activity in organotypic rat hippocampal slices
    Majid H Mohajerani
    Neuroscience Program, International School for Advanced Studies, Via Beirut 2 4, 34014 Trieste, Italy
    Eur J Neurosci 22:107-18. 2005
    ..This was in line with the transient bicuculline-induced block of GDPs and with the isoguvacine-induced increase of GDP frequency...
  13. ncbi Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats
    Rosa Maria A Simmons
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Mail Drop 0510, Indianapolis, IN 46285, USA
    Pharmacol Biochem Behav 73:419-27. 2002
    ..These results support the involvement of Group II mGlu2,3 receptors in persistent pain mechanisms and suggest the potential utility of selective Group II mGlu agonists for the treatment of persistent pain...
  14. ncbi AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala
    Annarosa Ugolini
    Department of Biology, Neuroscience Centre of Excellence for Drug Discovery, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre S p A, Via Fleming 4, 37135 Verona, Italy
    Neuropharmacology 55:532-6. 2008
    ..These results suggest that mGLUR7 has a unique role in regulating neuronal activity in the BLA and may be a target for novel drugs for the treatment of anxiety...
  15. ncbi Behavioural and neuronal activation after microinjections of AMPA and NMDA into the perifornical lateral hypothalamus in rats
    Frederick W Li
    Department of Anatomy and Neurobiology, Faculty of Medicine, Dalhousie University, 1459 Oxford Street, Halifax, Nova Scotia, B3H 4R2, Canada
    Behav Brain Res 224:376-86. 2011
    ..These results support the role of ionotropic glutamate receptors on OX and other neurons in the PeFLH in the regulation of locomotor and ingestive behaviours...
  16. ncbi Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception
    Dongni Yang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:6388-93. 2002
    ....
  17. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    Peter V Massey
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:7821-8. 2004
    ..Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex...
  18. ncbi N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina
    T T Lam
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, USA
    Invest Ophthalmol Vis Sci 40:2391-7. 1999
    ..The involvement of apoptosis in N-methyl-D-aspartate (NMDA)-induced excitotoxicity in adult rat retinas was examined...
  19. ncbi The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 49:13-25. 2005
    ..In addition, the mGlu5 selective agonist CHPG ((RS)-2-chloro-5-hydroxyphenylglycine) sets the molecular switch. These data demonstrate that the operation of the molecular switch requires activation of mGlu5 receptors...
  20. ncbi Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core
    N Armstrong
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Neuron 28:165-81. 2000
    ..The crystal packing of the ligand binding cores suggests modes for subunit-subunit contact in the intact receptor and mechanisms by which allosteric effectors modulate receptor activity...
  21. ncbi ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Neurosci Res 86:136-44. 2008
    ..ERK1 appears to play a major role in this process. These new findings on retinal glial cell response during NMDA injury offer an important new therapeutic target for preventing many retinal disorders associated with excitotoxicity...
  22. pmc Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Neurotherapeutics 6:94-107. 2009
    ..This review examines the multipotential therapeutic utility of mGluR modulation in acute and chronic injury and neurodegeneration...
  23. ncbi Differential activation of individual subunits in heteromeric kainate receptors
    Geoffrey T Swanson
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
    Neuron 34:589-98. 2002
    ....
  24. pmc GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation
    Nilkantha Sen
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 63:81-91. 2009
    ..In intact mice, virally delivered GOSPEL selectively diminishes NMDA neurotoxicity. Thus, GOSPEL may physiologically regulate the viability of neurons and other cells...
  25. ncbi Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death
    J van Beek
    European Institute for Peptide Research IFRMP 23, INSERM U519, Rouen, France
    Neuroreport 12:289-93. 2001
    ..These observations suggest that C3a is involved in excitotoxicity-mediated neuronal death through astrocyte stimulation and extend its role beyond immune functions...
  26. ncbi New insights from the use of pilocarpine and kainate models
    J P Leite
    Department of Neurology, University of São Paulo School of Medicine at Ribeirão Preto, Campus Universitario, Ribeirao Preto, Brazil
    Epilepsy Res 50:93-103. 2002
    ..Most of current tools used to quantify spontaneous seizure events need to be coupled to electrophysiology and more sophisticated systems for recording and analyzing behavior...
  27. ncbi mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
    K Walker
    Novartis Pharma AG, Nervous System Research, CH 4002, Basle, Switzerland
    Neuropharmacology 40:10-9. 2001
    ..These results suggest that mGlu5 receptors expressed on the peripheral terminals of sensory neurones are involved in nociceptive processes and contribute to the hyperalgesia associated with inflammation...
  28. ncbi Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism
    Frédéric Lebrun-Julien
    Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
    J Neurosci 29:5536-45. 2009
    ..Thus, our data reveal a novel non-cell-autonomous mechanism by which glial cells can profoundly exacerbate neuronal death following excitotoxic injury...
  29. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
    ..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation...
  30. ncbi Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus
    Kenji Kawaguchi
    Department of Neurology, University of Pittsburgh, PA 15260, USA
    Brain Res 1050:130-7. 2005
    ..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective...
  31. pmc Spontaneous voltage oscillations in striatal projection neurons in a rat corticostriatal slice
    R Vergara
    Department of Biophysics, Instituto de Fisiología Celular UNAM, Mexico City 04510, Mexico
    J Physiol 553:169-82. 2003
    ..These data show that NMDA and L-type Ca2+ conductances of spiny neurons are capable of rendering them bistable. This may help to support prolonged depolarizations and voltage oscillations under certain conditions...
  32. ncbi mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C
    V A Skeberdis
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neuropharmacology 40:856-65. 2001
    ..As Group I mGluRs are localized to the perisynaptic region in juxtaposition to NMDARs at glutamatergic synapses, mGluR-mediated potentiation of NMDAR activity may play a role in synaptic transmission and plasticity including LTP...
  33. ncbi Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures
    Suzanne B Bausch
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 92:3582-95. 2004
    ....
  34. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
  35. ncbi Mechanism of partial agonist action at the NR1 subunit of NMDA receptors
    Atsushi Inanobe
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Neuron 47:71-84. 2005
    ..The NR1-cycloleucine complex forms a dimer that is similar to the GluR2 dimer, thereby suggesting a conserved mode of subunit-subunit interaction in AMPA and NMDA receptors...
  36. ncbi Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia
    W L Bao
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Rm. EP12, 20007, Washington, DC 20007, USA
    Brain Res 922:173-9. 2001
    ..Therefore, both types of compounds may prove to have therapeutic potential for the treatment of stroke...
  37. ncbi Glutamate receptors at atomic resolution
    Mark L Mayer
    Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nature 440:456-62. 2006
    ....
  38. pmc Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors
    Enza Palazzo
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neuropharmacology 55:537-45. 2008
    ....
  39. ncbi Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 mice
    Zhiguo Chen
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Karolinska University Hospital, Stockholm 14186, Sweden
    J Neurobiol 62:207-18. 2005
    ..In summary, KA administration results in an early microglial activation and a prolonged astrogliosis in C57BL/6 mice...
  40. pmc Development of spontaneous recurrent seizures after kainate-induced status epilepticus
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 29:2103-12. 2009
    ....
  41. pmc Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors
    Susan M Carlton
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 31:12727-37. 2011
    ..They are endogenously activated after high-frequency and/or prolonged nociceptor stimulation, acting as built-in negative modulators of TRPV1 and nociceptor function, reducing pain transmission to the CNS...
  42. ncbi Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
    Anna Leena Sokka
    Minerva Medical Research Institute, Biomedicum Helsinki, FIN 00290 Helsinki, Finland
    J Neurosci 27:901-8. 2007
    ..Inhibition of ER stress by small molecular compounds may be beneficial for treatment of various neuronal injuries and brain disorders...
  43. ncbi Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina
    R Ientile
    Department of Biochemical, Physiological and Nutritional Sciences, Faculty of Medicine, University of Messina, Messina, Italy
    J Neurochem 79:71-8. 2001
    ....
  44. ncbi Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells
    Zare Melyan
    Centre for Neuroscience, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Neuron 34:107-14. 2002
    ..These data suggest how KARs, putatively containing GluR6, directly increase excitability of CA1 pyramidal cells and help explain the propensity for seizure activity following KAR activation...
  45. ncbi NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153
    Maiko Awai
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    J Neurochem 96:43-52. 2006
    ..In conclusion, CHOP is induced in mouse retina by NMDA treatment, and CHOP/ mice are more resistant to NMDA-induced retinal damage, suggesting that CHOP plays an important role in NMDA-induced retinal cell death...
  46. ncbi NMDA-induced phosphorylation of the microtubule-associated protein MAP-2 is mediated by activation of nitric oxide synthase and MAP kinase
    M Llansola
    Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, , Amadeo de Saboya, 4. 46010 Valencia, Spain
    Eur J Neurosci 13:1283-91. 2001
    ..The interplay between NMDA receptors-associated signal transduction pathways and MAP-2 may be involved in the modulation of neuronal responses to extracellular signals and in the regulation of neuronal function...
  47. ncbi Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina
    Shin Ichi Manabe
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Invest Ophthalmol Vis Sci 44:385-92. 2003
    ....
  48. pmc Modulation of a voltage-gated calcium channel linked to activation of glutamate receptors and calcium-induced calcium release in the catfish retina
    C L Linn
    Western Michigan University, Department of Biological Sciences, 1903 W Michigan Avenue, Kalamazoo, MI 49008, USA
    J Physiol 535:47-63. 2001
    ..Inhibition of this calcium current directly or indirectly involves calmodulin and CaM kinase II and represents a possible mechanism used by horizontal cells to affect response properties of these cells...
  49. ncbi Presynaptic group 1 metabotropic glutamate receptors may contribute to the expression of long-term potentiation in the hippocampal CA1 region
    D Manahan-Vaughan
    Leibniz Institute for Neurobiology, Department of Neurophysiology, Magdeburg, Germany
    Neuroscience 94:71-82. 1999
    ..This effect may contribute to group 1 metabotropic glutamate modulation of the expression of long-term potentiation in vivo...
  50. ncbi Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile
    J A Saugstad
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201, USA
    Mol Pharmacol 51:119-25. 1997
    ..Thus, cellular responses mediated by both group II and III agonists may in some cases reflect activation of mGluR8 rather than multiple mGluR subtypes...
  51. ncbi Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cells
    Wei Fan
    Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 30:1471-5. 2010
    ..Thus, the discharge of multiple Schaffer collaterals to a targeted cell is necessary for mGluR-LTD. Our experiments indicate that approximately eight CA3 inputs to a CA1 pyramidal cell must be activated to induce mGluR-LTD...
  52. ncbi Glutamate receptors communicate with Na+/K+-ATPase in rat cerebellum granule cells: demonstration of differences in the action of several metabotropic and ionotropic glutamate agonists on intracellular reactive oxygen species and the sodium pump
    Alexander Boldyrev
    Center for Molecular Medicine and International Biotechnological Center of M V Lomonosov Moscow State University Department of Biochemistry, Lenin s Hills, 119992 Moscow, Russia
    J Mol Neurosci 21:213-22. 2003
    ..Thus, the data presented illustrate the existence of diverse mechanisms of the cross talk between Na+/K+-ATPase and different glutamate receptors, as well as that between glutamate receptors of different classes...
  53. pmc NMDA-evoked calcium transients and currents in the suprachiasmatic nucleus: gating by the circadian system
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioural Sciences, University of California, Los Angeles, 90024, USA
    Eur J Neurosci 13:1420-8. 2001
    ..This study provides the first evidence for a circadian oscillation in NMDA-evoked Ca2+ transients in SCN cells. This rhythm may play an important role in determining the periodic sensitivity of the circadian systems response to light...
  54. ncbi Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare
    Christopher J Price
    Medical Research Council, Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    Neuropharmacology 49:45-56. 2005
    ..Our results show powerful modulation of excitatory transmission impinging on interneurons of CA1 SLM by presynaptic group II or III mGluRs...
  55. ncbi AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization
    Antoine Robert
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:3752-62. 2005
    ..The results suggest that the stability of cleft closure has been tuned so that glutamate dissociates as rapidly as possible yet remains a full agonist...
  56. ncbi (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology
    Lotte Brehm
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Med Chem 46:1350-8. 2003
    ..We are able to rationalize the observed selectivities by comparing the docking of 4 and 6 to subtype constructs, i.e., a crystal structure of the extracellular binding domain of GluR2 and a homology model of GluR5...
  57. ncbi Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina
    A Laabich
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 40202, USA
    Brain Res Mol Brain Res 91:34-42. 2001
    ..The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina...
  58. ncbi Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons
    Hui Juan Hu
    Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:13181-91. 2007
    ..2-containing potassium channels in dorsal horn neurons. This modulation may contribute to nociceptive plasticity and central sensitization associated with chronic inflammatory pain conditions...
  59. pmc mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner
    Heather B Gosnell
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neuropsychopharmacology 36:1599-607. 2011
    ..These studies show that mGluR8 is an important regulator of excitatory transmission in the BNST, and suggest that this receptor is selectively disrupted by noradrenergic signaling and by both acute and chronic stress...
  60. ncbi Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear
    Iulia Toth
    University of Regensburg, Faculty of Biology and Preclinical Medicine, Regensburg, Germany
    Neuropharmacology 62:1619-26. 2012
    ....
  61. ncbi Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro
    A Alt
    Lilly Research Laboratories, Eli Lilly and Company, Neuroscience Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 46:793-806. 2004
    ....
  62. ncbi Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep
    S Dolan
    University of Glasgow, Department of Veterinary Preclinical Studies, Bearsden Road, G61 1QH, Glasgow, UK
    Neuropharmacology 43:319-26. 2002
    ..In addition, the analgesic and anti-hyperalgesic actions of group II mGluRs suggest that these receptors play a crucial role in modulating acute inflammatory hyperalgesia...
  63. ncbi Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability
    J P Clement
    Department of Anatomy, Wyeth Applied Neurophysiology Group, University of Bristol School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Eur J Neurosci 29:2347-62. 2009
    ..DHPG-LDE did not involve HCN channels or protein synthesis, but was eliminated by blockers of protein kinase C or tyrosine phosphatases...
  64. ncbi Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus
    N Varma
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 21:RC188. 2001
    ..We conclude that group I mGluR-induced enhancement of DSI, and suppression of IPSCs, is actually mediated by endocannabinoids. This surprising result opens up new approaches to the investigation of cannabinoid actions in the brain...
  65. ncbi Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    D D Schoepp
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 38:1431-76. 1999
    ..This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents...
  66. ncbi The role of NMDAR subtypes and charge transfer during hippocampal LTP induction
    Sven Berberich
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuropharmacology 52:77-86. 2007
    ..Thus, at least for LFS pairing, the amount of charge transfer, and thus Ca2+ influx, during LTP induction is a factor more critical than the participation of a particular NMDAR subtype...
  67. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009
    ..These data suggest that mGluR5 represents a novel target for modulating microglial-dependent neuroinflammation, and may have therapeutic relevance for neurological disorders that exhibit microglial-mediated neurodegeneration...
  68. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory...
  69. ncbi Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus
    Arek Szklarczyk
    Laboratory of Molecular Neurobiology, Nencki Institute, PL 02 093 Warsaw, Poland
    J Neurosci 22:920-30. 2002
    ..This unique spatiotemporal pattern of MMP-9 expression suggests its involvement in activity-dependent remodeling of dendritic architecture with possible effects on synaptic physiology...
  70. ncbi Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    F Karim
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 21:3771-9. 2001
    ....
  71. ncbi The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    S A Henry
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 43:1199-209. 2002
    ..The effects of MPEP on the response to PCP may reflect the cooperation and co-localization of NMDA and mGlu5 receptors...
  72. ncbi The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus
    F Edward Dudek
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523, USA
    Prog Brain Res 135:53-65. 2002
    ....
  73. ncbi Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 49:762-71. 2008
    ..In the present study, we characterized the time course and cellular localization of OPN expression in the rat retina after excitotoxic and ischemic injuries...
  74. ncbi Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells
    Katsuhiko Sakamoto
    Neuroscience Institute and NSF Center for Behavioural Neuroscience, Morehouse School of Medicine, 720, Atlanta, GA 30310 1495, USA
    Eur J Neurosci 22:3129-36. 2005
    ..Our study also suggests that DA may have an important role in mediating the light signals that are used for circadian entrainment and for other responses that are mediated by the nonimage-forming visual system...
  75. ncbi Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception
    Ida Marabese
    Dept of Experimental Medicine, Sect of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Constantinopoli, Naples, Italy
    J Neurophysiol 98:43-53. 2007
    ..The opposite effects on pain behavior correlate with the opposite roles played by mGluR(7) and mGluR(8) on glutamate and GABA release and the ongoing and tail flick-related activities of the RVM on and off cells...
  76. ncbi Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse
    John P Vessey
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Neurosci 25:4108-17. 2005
    ..Voltage clamp of isolated HCs revealed an amiloride-sensitive conductance that could mediate modulation of cleft pH dependent on the membrane potential of these postsynaptic cells...
  77. ncbi Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons
    Pamela J Voulalas
    Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:3763-73. 2005
    ..Thus, signal transduction pathways activated by DR1/5 and mGluR5 interact to modify downstream events in striatal neurons while retaining numerous regulatory checkpoints...
  78. ncbi mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity
    Alexandra C Soliman
    Department of Neurology and Neurosurgery, McGill University, 3801 University St, Montreal, Quebec H3A 2B4
    Neuropharmacology 48:325-32. 2005
    ..We conclude that mGlu receptors contribute to the development of mechanical allodynia, but not thermal hyperalgesia, following capsaicin injury; while iGluRs may contribute to both thermal and mechanical hypersensitivity...
  79. pmc Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    Ann Neurol 66:63-74. 2009
    ..Previously, mGluR5 has been identified on microglia in vitro, but the effects of mGluR5 activation on inflammation in vivo or on recovery after spinal cord injury is unknown...
  80. ncbi Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    ..The group ImGluR-NMDAR coupling cascade leads to phosphorylation of the NMDAR and appears necessary for the initiation of spinal dorsal horn sensitization and behavioral hyperalgesia after inflammation...
  81. pmc Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1
    Joyce Wondolowski
    Department of Behavioral Neuroscience and Neuroscience Graduate Program, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 29:563-74. 2009
    ..GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms...
  82. ncbi Role of glutamate autoreceptors at hippocampal mossy fiber synapses
    Hyung Bae Kwon
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 60:1082-94. 2008
    ..Thus, negative feedback via presynaptic mGluRs is the dominant mode of glutamatergic autoregulation at the mf-CA3 synapse...
  83. ncbi Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
    Wade Morishita
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropharmacology 52:71-6. 2007
    ..These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus...
  84. ncbi The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus
    M J Palmer
    Department of Anatomy, School of Medical Sciences, University of Bristol, UK
    Neuropharmacology 36:1517-32. 1997
    ..These data show that activation of group I mGlu receptors (probably mGlu5) can induce LTD and that this mGlu receptor-mediated LTD may, or may not, require activation of NMDA receptors, depending on the experimental conditions...
  85. ncbi Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture
    S J Hewett
    Department of Pharmacology, Program in Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 6125, USA
    J Pharmacol Exp Ther 293:417-25. 2000
    ..Together, these results support the conclusion that newly synthesized COX-2 protein contributes to NMDA-induced neuronal injury...
  86. ncbi The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening
    Kevin S Jones
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:2044-53. 2002
    ..Furthermore, amino acid homology between glutamate receptor M3 segments and the equivalent S6 or TM2 segments in K(+) channels suggests that ion channel activation and gating are both structurally and functionally conserved...
  87. ncbi The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus
    T Kunz
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala Biomedical Centre, PO Box 591, SE 751 24 Uppsala, Sweden
    Eur J Neurosci 13:569-75. 2001
    ..Therefore we conclude that COX-2 might contribute to cell death of pyramidal cells of the hippocampus as a consequence of limbic seizures...
  88. pmc Reactive astrocytosis from excitotoxic injury in hippocampal organ culture parallels that seen in vivo
    P E Kunkler
    Department of Neurology, University of Chicago, IL 60637, USA
    J Cereb Blood Flow Metab 17:26-43. 1997
    ....
  89. ncbi Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults
    Angela L Lee
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Neurochem 86:1079-88. 2003
    ..This difference raises the possibility that the means by which these channel subtypes protect may differ. With further development, potassium channel vectors may be an effective pre-emptive strategy against necrotic insults...
  90. ncbi Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones
    J Nagy
    Pharmacological and Drug Safety Research, Gedeon Richter Ltd Gyömröi str 19 21, H 1475 Budapest, Hungary
    Drug Alcohol Depend 61:155-62. 2001
    ....
  91. ncbi Investigations of the protein synthesis dependency of mGluR-induced long-term depression in the dentate gyrus of freely moving rats
    Katja Naie
    Institute for Physiology of the Charite, Synaptic Plasticity Research Group, Humboldt University, Berlin, Germany
    Neuropharmacology 49:35-44. 2005
    ..Whereas AP4-induced LTD may arise as a result of modulation of presynaptic glutamate release mechanisms, the protein synthesis dependency of DHPG-induced LTD suggests an additional postsynaptic expression mechanism for this phenomenon...
  92. ncbi Both mGluR1 and mGluR5 mediate Ca2+ release and inward currents in hippocampal CA1 pyramidal neurons
    Mark G Rae
    Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Neuropharmacology 46:1057-69. 2004
    ....
  93. ncbi mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082
    Kenneth A Pelkey
    Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 35, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Neuropharmacology 52:108-17. 2007
    ..Thus, AMN082 will be effective for investigating physiological processes related to both mGluR7 activation and internalization such as control of bidirectional plasticity at mossy fiber-st. lucidum interneuron synapses...
  94. ncbi IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice
    Zhiguo Chen
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 17:171-8. 2004
    ..In summary, this study indicates that IL-12 may play a critical role in excitotoxin-induced brain injury...
  95. pmc Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    Mala M Shah
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 44:495-508. 2004
    ..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks...
  96. ncbi Group I mGluRs increase excitability of hippocampal CA1 pyramidal neurons by a PLC-independent mechanism
    David R Ireland
    Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
    J Neurophysiol 88:107-16. 2002
    ....
  97. pmc Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cells
    G T Swanson
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Physiol 513:639-46. 1998
    ..At synapses such mechanisms could regulate the frequency- response relationship of synaptic kainate receptors by altering their rate of entry into and recovery from desensitization...
  98. ncbi Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate
    Jerome Jourquin
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, CNRS FRE 2533 IFR Jean Roche Université de la Méditerranée Faculté de Médecine de Marseille, 27 Bd Jean Moulin 13385, Marseille Cedex 05, France
    Eur J Neurosci 18:1507-17. 2003
    ....
  99. ncbi Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase
    G Fuller
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res Mol Brain Res 89:126-32. 2001
    ..This provides evidence for a novel pathway linking striatal kainate receptors to ERK activation via PI3 kinase and MEK...
  100. ncbi Comparative behavioral changes between male and female postpubertal rats following neonatal excitotoxic lesions of the ventral hippocampus
    Adriana B Silva-Gómez
    Escuela Superior de Medicina del IPN, D F, Mexico
    Brain Res 973:285-92. 2003
    ....
  101. ncbi Differential properties of dentate gyrus and CA1 neural precursors
    H Becq
    INMED INSERM U29, Marseille, France
    J Neurobiol 62:243-61. 2005
    ..These results suggest that CA1 precursors are more stem-cell-like than granule cell precursors, which may represent a more restricted precursor cell...

Research Grants62

  1. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
  2. EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITRO
    JOHN DELFS; Fiscal Year: 1992
    ..The long-term objective of this research is to understand better the role of excitotoxins in spinal neuron degeneration and death...
  3. HYPOTHERMIA AND TRAUMA
    Larry Jenkins; Fiscal Year: 2000
    ....
  4. HEROIN AIDS ENCEPHALOPATHY--NEUROPATHOGENESIS MECHANISMS
    Madhavan Nair; Fiscal Year: 2005
    ..We further demonstrated that in vivo stereotaxic injection of HIV proteins plus excitatory amino acid agonists into the dorsal hippocampus of neonatal rat brains causes both gross and microscopic neuropathology...
  5. NEURAL BASIS OF AUDIO-VOCAL INTEGRATION
    Walter Metzner; Fiscal Year: 1999
    ....
  6. QUISQUALATE SENSITIZATION AND NEUROTOXICITY
    JAMES KOERNER; Fiscal Year: 1999
    ..They will also contribute to understanding of the neurotoxicity of glutamate and other excitatory amino acids. These toxic responses are also triggered by ischemia and may be the basis for the neuronal damage that accompanies stroke. ..
  7. Use of Novel Cox-2 Inhibitors in Neurological Disorders
    STANLEY BELL; Fiscal Year: 2006
    ....
  8. AIDS encephalopathy and HIV disease: role of opioids
    Madhavan Nair; Fiscal Year: 2006
    ..We further demonstrated that in vivo stereotaxic injection of HIV proteins plus excitatory amino acid agonists into the dorsal hippocampus of neonatal rat brains causes both gross and microscopic neuropathology...
  9. PERINATAL HIV INFECTIONS--PREVENTION OF CNS PATHOLOGY
    Stanley Schwartz; Fiscal Year: 1999
    ....
  10. MECHANISMS OF LEAD NEUROTOXICITY
    David Carpenter; Fiscal Year: 1992
    ..cortex we will a) determine sensitivity of response to iontophoretic application of three "specific" excitatory amino acid agonists (NMDA, kainate and quisqualate) to lead, and b) determine sensitivity to lead of the monosynaptic ..
  11. DOPAMINE SYSTEM INTERACTIONS AND SCHIZOPHRENIA
    ARIEL DEUTCH; Fiscal Year: 2004
    ..of the NAS and PFC DA innervations to agents that evoke DA release (KC1 and amphetamine) and to excitatory amino acid agonists (NMDA and AMPA)...
  12. REGULATE CA-2+ FOLLOWING ACTIVATION OF NMDA RECEPTOR
    AMY MACDERMOTT; Fiscal Year: 1991
    ..may control pattern generation in efferent motor systems, as well as the excitotoxic action of some excitatory amino acid agonists. The three sources of calcium that may contribute to the elevation of intracellular calcium following ..
  13. REGULATION OF DENDRITIC SPINES
    Shelley Halpain; Fiscal Year: 2002
    ..The present investigation will utilize a cell biological approach to determine the molecular mechanism underlying spine regulation. ..
  14. NEONATAL HYPOXIC-ISCHEMIC WHITE MATTER INJURY
    Faye Silverstein; Fiscal Year: 2003
    ....
  15. CHARACTERIZATION OF EXCITATORY AMINO ACID TRANSMITTER
    Jeffrey Watkins; Fiscal Year: 1993
    ..New excitatory amino acid agonists and antagonists will be synthesized and their actions characterized by well-proven screening ..
  16. ESTROGEN--MECHANISMS OF RAPID ACTION IN THE HIPPOCAMPUS
    Qin Gu; Fiscal Year: 1999
    ..Completion of the proposed studies will reveal the intracellular pathways through which estrogen acts to exert rapid effects on an excitatory neurotransmitter in the hippocampus. ..
  17. ION CHANNELS IN MACULAR MULLER CELLS OF THE HUMAN RETINA
    DONALD PURO; Fiscal Year: 1999
    ..Knowledge of the mechanisms regulating K+ homeostasis in the macula may help us gain insights concerning retinal pathobiology. ..
  18. MOLECULAR MECHANISMS OF OPIOIDS AS COFACTORS IN AIDS
    Stanley Schwartz; Fiscal Year: 2002
    ..of our in vitro CNS findings will be undertaken using our established rat mode1 wherein HIV proteins + excitatory amino acid agonists + morphine will be stereotactically injected into the dorsal hippocampus...
  19. TREATMENT OF NEGATIVE SYMPTOMS AND COGNITIVE IMPAIRMENTS
    Daniel Javitt; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d-cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  20. MECHANISMS OF COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2005
    ..This study will evaluate neurophysiological and neurochemical hypotheses concerning potential etiology of early sensory processing dysfunction in schizophrenia. ..
  21. Phencyclidine Abuse & Psychosis: Biomedical Mechanisms
    Daniel C Javitt; Fiscal Year: 2010
    ....
  22. NEUROPHYSIOLOGICAL NMDA DYSFUNCTION IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2006
    ..The research will build upon studies currently supported by NIH research and career development awards to the candidate, and will permit the candidate to continue to devote >75 percent effort to research. ..
  23. High-Density ERP mapping & FMRI
    Daniel Javitt; Fiscal Year: 2002
    ..The equipment will also permit monitoring of background EEG during both human and animal studies. Software is requested for state-of-the-art ERP dipole mapping and ERP/MRI co-registration. ..
  24. Aging as a risk factor for seizure-induced cell death
    PAULA SCHAUWECKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. Retinal Inputs to the Mammalian Circadian Pacemaker
    KWOON WONG; Fiscal Year: 2006
    ..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..
  26. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  27. DEVELOPMENT AND REORGANIZATION OF PRENATAL VISUAL SYSTEM
    Barbara Chapman; Fiscal Year: 2010
    ..This information will be useful in devising empirically based treatments of the myriad ontogenetic disorders than adversely impact the human visual system. ..
  28. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  29. Growth factor effects on dental pulp cells
    DOUGLAS LOBNER; Fiscal Year: 2008
    ..As a method of maintaining the viability of these cells we are proposing studying the effects of naturally occurring substances called growth factors on dental pulp cells. [unreadable] [unreadable] [unreadable]..
  30. ELEMENTARY SCHOOL NEUROSCIENCE LITERACY
    Gary Duncan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Genetic Regulation of Seizure-Induced Neurogenesis
    PAULA SCHAUWECKER; Fiscal Year: 2004
    ..abstract_text> ..
  33. K + EFFLUX--ROLE IN CA++ HOMEOSTASIS AND EXCITOTOXICITY
    Lech Kiedrowski; Fiscal Year: 2003
    ..These studies may yield a new target for pharmacological intervention to decrease neuronal death following ischemia or hypoglycemia, namely, to prevent excessive K+ loss from the brain during reperfusion. ..
  34. MECHANISMS OF INJURY POTENTIATION BY GROWTH FACTORS
    DOUGLAS LOBNER; Fiscal Year: 2004
    ..It is believed that these studies will aid in determining under what conditions growth factor induced potentiation of cell death may be of concern regarding their therapeutic use, and how those concerns may be addressed. ..
  35. Improving memory after hippocampal cell loss
    MARK BARDGETT; Fiscal Year: 2007
    ..The results may shed light on new directions in the treatment of memory disorders, and the proposed work will also enhance education in biomedical research among college undergraduates in Kentucky. [unreadable] [unreadable] [unreadable]..
  36. Contribution of the PAG to morphine tolerance
    Michael Morgan; Fiscal Year: 2002
    ..In the long term, such knowledge should improve the treatment of pain by allowing therapies that disrupt tolerance to be developed. ..
  37. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  38. SYNAPTIC ALTERATIONS AFTER HYPOGLYCEMIC SEIZURES
    Kelvin Yamada; Fiscal Year: 2008
    ..Understanding mechanisms of diabetes/diabetes complication-induced brain dysfunction may lead to new targets for treatment interventions to prevent or retard cognitive impairment in diabetes. ..
  39. Dendritic Processing in the Olfactory Bulb
    Jason Christie; Fiscal Year: 2003
    ..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
  40. DOPAMINERGIC MODULATION OF THE STARTLE REFLEX
    Michael Davis; Fiscal Year: 2004
    ..They also will evaluate whether conditioned fear uses some of the same circuitry to facilitate reflex behavior and how outputs from the amygdala intersect with this circuitry. ..
  41. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  42. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  43. ROLE OF BED NUCLEUS OF STRIA TERMINALIS IN FEAR/ANXIETY
    Michael Davis; Fiscal Year: 2001
    ..Other studies will evaluate whether the BNST can 'take over' for the amygdala in fear-potentiated startle using lesion, chemical inactivation and IC-fosI methodologies. ..
  44. Hypoglycemia in the Developing Diabetic Brain
    Kelvin Yamada; Fiscal Year: 2005
    ..g., spatial motor, memory, leaning tasks), and finally addressing whether hypoglycemia and diabetes have synergistic injurious effects upon the developing brain. ..
  45. Prostanoid Modulation of Neuronal Death
    Noel Carlson; Fiscal Year: 2005
    ..abstract_text> ..
  46. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  47. Investigation of Dopamine Function In Human Amygdala
    LAWRENCE CAHILL; Fiscal Year: 2004
    ..The data derived from these preliminary experiments should lay the foundation for a research program aimed at understanding how DA mechanisms within the human amygdala subserve both emotional memory and addiction. ..
  48. Ethanol Effects in the Mammalian Circadian Clock
    Rebecca Prosser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2002
    ..These studies will provide insights into the molecular interaction of this group of Vas with specific neuronal components, which may facilitate the design of improved general anesthetics. ..
  50. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2010
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  51. The Delayed Effects of Phencyclidine: Mechanisms
    Sarah Turgeon; Fiscal Year: 2002
    ..These experiments will begin to identify the mechanisms by which PCP produces schizophrenia-like behaviors in animals, providing insight into potential pathophysiologies underlying schizophrenia in humans. ..
  52. Coping with the Threat of Terror
    Brett Litz; Fiscal Year: 2007
    ..Our results will provide tools to study the way people cope with unprecedented worries about future terror, which will greatly enhance the public health response to terror. [unreadable] [unreadable] [unreadable]..
  53. Regulation of CBP by Synaptic Activity
    Soren Impey; Fiscal Year: 2005
    ..This will be accomplished by conducting the above described research, attending and presenting at local and national seminars and meetings, and participating in courses teaching molecular biology and neurophysiology techniques. ..
  54. Role of (Cl-)i alterations on GABA function after TBI
    DONNA GEDDES; Fiscal Year: 2005
    ..Understanding the mechanism of injury induced [CI-]I alterations will aid in the development of better treatments for post-traumatic seizures. ..
  55. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2005
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  56. PROPERTIES AND ROLES OF EXCITATORY AMINO ACID TRANSPORT
    Richard Bridges; Fiscal Year: 2006
    ..The results of this project will provide significant insight into the properties of the excitatory amino acid transporters and their ability to regulate the physiological and pathological levels of glutamate in the CNS. ..
  57. NEUROSTEROIDS IN THE ACTION OF ETHANOL ON GABA
    George Breese; Fiscal Year: 2004
    ..Completion of the Aims will allow critical new information to emerge concerning the molecular basis of neurosteroid action on GABAA receptor function that allows ethanol to enhance GABA function in vitro. ..
  58. PHYSIOLOGY OF ZINC PERMEABLE AMPA/KAINATE RECEPTORS
    Stefano Sensi; Fiscal Year: 2003
    ..It is hoped that these studies will increase understanding of cell injury mechanisms in diseases of aging and suggest new therapies. ..
  59. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
    ..e. on nNOS immunoreactive dendrites or neurons in NTS. ..
  60. Modulation of calcium signaling by presenilin-1
    Peter Koulen; Fiscal Year: 2003
    ..Thus, potential new targets for treating those devastating conditions affecting the aging population may be identified. ..
  61. Physical Activity Dependent Plasticity CNS Sympathetic Nervous System Regulation
    Patrick Mueller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..