excitatory amino acid agonists

Summary

Summary: Drugs that bind to and activate excitatory amino acid receptors.

Top Publications

  1. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
  2. doi STAT3 activation protects retinal ganglion cell layer neurons in response to stress
    Chun Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Eye Res 86:991-7. 2008
  3. ncbi Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7
    G Sansig
    Nervous System Department, Novartis Pharma AG, CH 4002 Basel, Switzerland
    J Neurosci 21:8734-45. 2001
  4. doi Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 49:762-71. 2008
  5. ncbi Effects of D-cycloserine on extinction of conditioned freezing
    Lana Ledgerwood
    School of Psychology, University of New South Wales, Sydney, Australia
    Behav Neurosci 117:341-9. 2003
  6. ncbi Pharmacology and functions of metabotropic glutamate receptors
    P J Conn
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 37:205-37. 1997
  7. pmc Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
    J Cell Biol 181:551-65. 2008
  8. ncbi N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina
    T T Lam
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, USA
    Invest Ophthalmol Vis Sci 40:2391-7. 1999
  9. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009
  10. ncbi ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Neurosci Res 86:136-44. 2008

Detail Information

Publications229 found, 100 shown here

  1. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
  2. doi STAT3 activation protects retinal ganglion cell layer neurons in response to stress
    Chun Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Eye Res 86:991-7. 2008
    ..Our results suggest that persistent activation of STAT3 by neurotrophic factors provides strong neuroprotection and will be an effective strategy in a number of chronic retinal diseases...
  3. ncbi Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7
    G Sansig
    Nervous System Department, Novartis Pharma AG, CH 4002 Basel, Switzerland
    J Neurosci 21:8734-45. 2001
    ..Our findings suggest that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs...
  4. doi Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 49:762-71. 2008
    ..In the present study, we characterized the time course and cellular localization of OPN expression in the rat retina after excitotoxic and ischemic injuries...
  5. ncbi Effects of D-cycloserine on extinction of conditioned freezing
    Lana Ledgerwood
    School of Psychology, University of New South Wales, Sydney, Australia
    Behav Neurosci 117:341-9. 2003
    ..These results suggest that DCS facilitates extinction of conditioned freezing by acting on consolidation processes partly mediated by the basolateral amygdala...
  6. ncbi Pharmacology and functions of metabotropic glutamate receptors
    P J Conn
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 37:205-37. 1997
    ..These findings have exciting implications for drug development and suggest that the mGluRs provide a novel target for development of therepeutic agents that could have a significant impact on neuropharmacology...
  7. pmc Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
    J Cell Biol 181:551-65. 2008
    ..Thus, native PrP(C) mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits...
  8. ncbi N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina
    T T Lam
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, USA
    Invest Ophthalmol Vis Sci 40:2391-7. 1999
    ..The involvement of apoptosis in N-methyl-D-aspartate (NMDA)-induced excitotoxicity in adult rat retinas was examined...
  9. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009
    ..These data suggest that mGluR5 represents a novel target for modulating microglial-dependent neuroinflammation, and may have therapeutic relevance for neurological disorders that exhibit microglial-mediated neurodegeneration...
  10. ncbi ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Neurosci Res 86:136-44. 2008
    ..ERK1 appears to play a major role in this process. These new findings on retinal glial cell response during NMDA injury offer an important new therapeutic target for preventing many retinal disorders associated with excitotoxicity...
  11. pmc Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Neurotherapeutics 6:94-107. 2009
    ..This review examines the multipotential therapeutic utility of mGluR modulation in acute and chronic injury and neurodegeneration...
  12. ncbi The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 49:13-25. 2005
    ..In addition, the mGlu5 selective agonist CHPG ((RS)-2-chloro-5-hydroxyphenylglycine) sets the molecular switch. These data demonstrate that the operation of the molecular switch requires activation of mGlu5 receptors...
  13. ncbi Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core
    N Armstrong
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Neuron 28:165-81. 2000
    ..The crystal packing of the ligand binding cores suggests modes for subunit-subunit contact in the intact receptor and mechanisms by which allosteric effectors modulate receptor activity...
  14. ncbi Differential activation of individual subunits in heteromeric kainate receptors
    Geoffrey T Swanson
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
    Neuron 34:589-98. 2002
    ....
  15. ncbi Mechanism of partial agonist action at the NR1 subunit of NMDA receptors
    Atsushi Inanobe
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Neuron 47:71-84. 2005
    ..The NR1-cycloleucine complex forms a dimer that is similar to the GluR2 dimer, thereby suggesting a conserved mode of subunit-subunit interaction in AMPA and NMDA receptors...
  16. ncbi Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats
    P S Buckmaster
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    J Comp Neurol 385:385-404. 1997
    ....
  17. doi Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism
    Frédéric Lebrun-Julien
    Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
    J Neurosci 29:5536-45. 2009
    ..Thus, our data reveal a novel non-cell-autonomous mechanism by which glial cells can profoundly exacerbate neuronal death following excitotoxic injury...
  18. ncbi mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
    K Walker
    Novartis Pharma AG, Nervous System Research, CH 4002, Basle, Switzerland
    Neuropharmacology 40:10-9. 2001
    ..These results suggest that mGlu5 receptors expressed on the peripheral terminals of sensory neurones are involved in nociceptive processes and contribute to the hyperalgesia associated with inflammation...
  19. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
    ..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation...
  20. pmc Spontaneous voltage oscillations in striatal projection neurons in a rat corticostriatal slice
    R Vergara
    Department of Biophysics, Instituto de Fisiología Celular UNAM, Mexico City 04510, Mexico
    J Physiol 553:169-82. 2003
    ..These data show that NMDA and L-type Ca2+ conductances of spiny neurons are capable of rendering them bistable. This may help to support prolonged depolarizations and voltage oscillations under certain conditions...
  21. ncbi Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus
    Kenji Kawaguchi
    Department of Neurology, University of Pittsburgh, PA 15260, USA
    Brain Res 1050:130-7. 2005
    ..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective...
  22. ncbi Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia
    W L Bao
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Rm. EP12, 20007, Washington, DC 20007, USA
    Brain Res 922:173-9. 2001
    ..Therefore, both types of compounds may prove to have therapeutic potential for the treatment of stroke...
  23. ncbi Glutamate receptors at atomic resolution
    Mark L Mayer
    Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nature 440:456-62. 2006
    ....
  24. pmc Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors
    Enza Palazzo
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neuropharmacology 55:537-45. 2008
    ....
  25. ncbi Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 mice
    Zhiguo Chen
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Karolinska University Hospital, Stockholm 14186, Sweden
    J Neurobiol 62:207-18. 2005
    ..In summary, KA administration results in an early microglial activation and a prolonged astrogliosis in C57BL/6 mice...
  26. pmc Development of spontaneous recurrent seizures after kainate-induced status epilepticus
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 29:2103-12. 2009
    ....
  27. ncbi Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile
    J A Saugstad
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201, USA
    Mol Pharmacol 51:119-25. 1997
    ..Thus, cellular responses mediated by both group II and III agonists may in some cases reflect activation of mGluR8 rather than multiple mGluR subtypes...
  28. ncbi Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats
    Rosa Maria A Simmons
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Mail Drop 0510, Indianapolis, IN 46285, USA
    Pharmacol Biochem Behav 73:419-27. 2002
    ..These results support the involvement of Group II mGlu2,3 receptors in persistent pain mechanisms and suggest the potential utility of selective Group II mGlu agonists for the treatment of persistent pain...
  29. doi Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cells
    Wei Fan
    Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 30:1471-5. 2010
    ..Thus, the discharge of multiple Schaffer collaterals to a targeted cell is necessary for mGluR-LTD. Our experiments indicate that approximately eight CA3 inputs to a CA1 pyramidal cell must be activated to induce mGluR-LTD...
  30. ncbi AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization
    Antoine Robert
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:3752-62. 2005
    ..The results suggest that the stability of cleft closure has been tuned so that glutamate dissociates as rapidly as possible yet remains a full agonist...
  31. ncbi Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare
    Christopher J Price
    Medical Research Council, Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    Neuropharmacology 49:45-56. 2005
    ..Our results show powerful modulation of excitatory transmission impinging on interneurons of CA1 SLM by presynaptic group II or III mGluRs...
  32. ncbi Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina
    A Laabich
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 40202, USA
    Brain Res Mol Brain Res 91:34-42. 2001
    ..The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina...
  33. ncbi Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro
    A Alt
    Lilly Research Laboratories, Eli Lilly and Company, Neuroscience Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 46:793-806. 2004
    ....
  34. pmc mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner
    Heather B Gosnell
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neuropsychopharmacology 36:1599-607. 2011
    ..These studies show that mGluR8 is an important regulator of excitatory transmission in the BNST, and suggest that this receptor is selectively disrupted by noradrenergic signaling and by both acute and chronic stress...
  35. doi AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala
    Annarosa Ugolini
    Department of Biology, Neuroscience Centre of Excellence for Drug Discovery, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre S p A, Via Fleming 4, 37135 Verona, Italy
    Neuropharmacology 55:532-6. 2008
    ..These results suggest that mGLUR7 has a unique role in regulating neuronal activity in the BLA and may be a target for novel drugs for the treatment of anxiety...
  36. ncbi Glutamate receptors communicate with Na+/K+-ATPase in rat cerebellum granule cells: demonstration of differences in the action of several metabotropic and ionotropic glutamate agonists on intracellular reactive oxygen species and the sodium pump
    Alexander Boldyrev
    Center for Molecular Medicine and International Biotechnological Center of M V Lomonosov Moscow State University Department of Biochemistry, Lenin s Hills, 119992 Moscow, Russia
    J Mol Neurosci 21:213-22. 2003
    ..Thus, the data presented illustrate the existence of diverse mechanisms of the cross talk between Na+/K+-ATPase and different glutamate receptors, as well as that between glutamate receptors of different classes...
  37. pmc NMDA-evoked calcium transients and currents in the suprachiasmatic nucleus: gating by the circadian system
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioural Sciences, University of California, Los Angeles, 90024, USA
    Eur J Neurosci 13:1420-8. 2001
    ..This study provides the first evidence for a circadian oscillation in NMDA-evoked Ca2+ transients in SCN cells. This rhythm may play an important role in determining the periodic sensitivity of the circadian systems response to light...
  38. ncbi (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology
    Lotte Brehm
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Med Chem 46:1350-8. 2003
    ..We are able to rationalize the observed selectivities by comparing the docking of 4 and 6 to subtype constructs, i.e., a crystal structure of the extracellular binding domain of GluR2 and a homology model of GluR5...
  39. ncbi Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons
    Hui Juan Hu
    Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:13181-91. 2007
    ..2-containing potassium channels in dorsal horn neurons. This modulation may contribute to nociceptive plasticity and central sensitization associated with chronic inflammatory pain conditions...
  40. doi Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear
    Iulia Toth
    University of Regensburg, Faculty of Biology and Preclinical Medicine, Regensburg, Germany
    Neuropharmacology 62:1619-26. 2012
    ....
  41. doi Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability
    J P Clement
    Department of Anatomy, Wyeth Applied Neurophysiology Group, University of Bristol School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Eur J Neurosci 29:2347-62. 2009
    ..DHPG-LDE did not involve HCN channels or protein synthesis, but was eliminated by blockers of protein kinase C or tyrosine phosphatases...
  42. ncbi Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep
    S Dolan
    University of Glasgow, Department of Veterinary Preclinical Studies, Bearsden Road, G61 1QH, Glasgow, UK
    Neuropharmacology 43:319-26. 2002
    ..In addition, the analgesic and anti-hyperalgesic actions of group II mGluRs suggest that these receptors play a crucial role in modulating acute inflammatory hyperalgesia...
  43. ncbi Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus
    N Varma
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 21:RC188. 2001
    ..We conclude that group I mGluR-induced enhancement of DSI, and suppression of IPSCs, is actually mediated by endocannabinoids. This surprising result opens up new approaches to the investigation of cannabinoid actions in the brain...
  44. doi Role of glutamate autoreceptors at hippocampal mossy fiber synapses
    Hyung Bae Kwon
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 60:1082-94. 2008
    ..Thus, negative feedback via presynaptic mGluRs is the dominant mode of glutamatergic autoregulation at the mf-CA3 synapse...
  45. ncbi Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    D D Schoepp
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 38:1431-76. 1999
    ..This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents...
  46. ncbi The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus
    F Edward Dudek
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523, USA
    Prog Brain Res 135:53-65. 2002
    ....
  47. pmc Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1
    Joyce Wondolowski
    Department of Behavioral Neuroscience and Neuroscience Graduate Program, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 29:563-74. 2009
    ..GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms...
  48. ncbi Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    F Karim
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 21:3771-9. 2001
    ....
  49. ncbi Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neurobiol Dis 25:360-6. 2007
    ..The results provide further support for the hypothesis that BMAA plays a role in neurodegenerative diseases...
  50. ncbi New insights from the use of pilocarpine and kainate models
    J P Leite
    Department of Neurology, University of São Paulo School of Medicine at Ribeirão Preto, Campus Universitario, Ribeirao Preto, Brazil
    Epilepsy Res 50:93-103. 2002
    ..Most of current tools used to quantify spontaneous seizure events need to be coupled to electrophysiology and more sophisticated systems for recording and analyzing behavior...
  51. ncbi Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus
    Arek Szklarczyk
    Laboratory of Molecular Neurobiology, Nencki Institute, PL 02 093 Warsaw, Poland
    J Neurosci 22:920-30. 2002
    ..This unique spatiotemporal pattern of MMP-9 expression suggests its involvement in activity-dependent remodeling of dendritic architecture with possible effects on synaptic physiology...
  52. ncbi Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
    Wade Morishita
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropharmacology 52:71-6. 2007
    ..These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus...
  53. ncbi The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    S A Henry
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 43:1199-209. 2002
    ..The effects of MPEP on the response to PCP may reflect the cooperation and co-localization of NMDA and mGlu5 receptors...
  54. ncbi Group I mGluRs increase excitability of hippocampal CA1 pyramidal neurons by a PLC-independent mechanism
    David R Ireland
    Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
    J Neurophysiol 88:107-16. 2002
    ....
  55. ncbi Both mGluR1 and mGluR5 mediate Ca2+ release and inward currents in hippocampal CA1 pyramidal neurons
    Mark G Rae
    Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Neuropharmacology 46:1057-69. 2004
    ....
  56. ncbi Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults
    Angela L Lee
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Neurochem 86:1079-88. 2003
    ..This difference raises the possibility that the means by which these channel subtypes protect may differ. With further development, potassium channel vectors may be an effective pre-emptive strategy against necrotic insults...
  57. ncbi Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina
    Shin Ichi Manabe
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Invest Ophthalmol Vis Sci 44:385-92. 2003
    ....
  58. ncbi Investigations of the protein synthesis dependency of mGluR-induced long-term depression in the dentate gyrus of freely moving rats
    Katja Naie
    Institute for Physiology of the Charite, Synaptic Plasticity Research Group, Humboldt University, Berlin, Germany
    Neuropharmacology 49:35-44. 2005
    ..Whereas AP4-induced LTD may arise as a result of modulation of presynaptic glutamate release mechanisms, the protein synthesis dependency of DHPG-induced LTD suggests an additional postsynaptic expression mechanism for this phenomenon...
  59. ncbi Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones
    J Nagy
    Pharmacological and Drug Safety Research, Gedeon Richter Ltd Gyömröi str 19 21, H 1475 Budapest, Hungary
    Drug Alcohol Depend 61:155-62. 2001
    ....
  60. ncbi mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082
    Kenneth A Pelkey
    Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 35, 35 Lincoln Drive, Bethesda, MD 20892, USA
    Neuropharmacology 52:108-17. 2007
    ..Thus, AMN082 will be effective for investigating physiological processes related to both mGluR7 activation and internalization such as control of bidirectional plasticity at mossy fiber-st. lucidum interneuron synapses...
  61. ncbi IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice
    Zhiguo Chen
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 17:171-8. 2004
    ..In summary, this study indicates that IL-12 may play a critical role in excitotoxin-induced brain injury...
  62. pmc Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    Mala M Shah
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 44:495-508. 2004
    ..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks...
  63. pmc Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cells
    G T Swanson
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Physiol 513:639-46. 1998
    ..At synapses such mechanisms could regulate the frequency- response relationship of synaptic kainate receptors by altering their rate of entry into and recovery from desensitization...
  64. ncbi GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression
    Alexandre Serrano
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    J Neurosci 26:5370-82. 2006
    ..Thus, glial and neuronal networks are functionally associated during the genesis of heterosynaptic plasticity at mammalian central excitatory synapses...
  65. ncbi Comparative behavioral changes between male and female postpubertal rats following neonatal excitotoxic lesions of the ventral hippocampus
    Adriana B Silva-Gómez
    Escuela Superior de Medicina del IPN, D F, Mexico
    Brain Res 973:285-92. 2003
    ....
  66. ncbi NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes
    Ulyana Lalo
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 26:2673-83. 2006
    ..We conclude that cortical astrocytes express functional NMDA receptors that are devoid of Mg2+ block, and these receptors are involved in neuronal-glial signal transmission...
  67. ncbi Differential properties of dentate gyrus and CA1 neural precursors
    H Becq
    INMED INSERM U29, Marseille, France
    J Neurobiol 62:243-61. 2005
    ..These results suggest that CA1 precursors are more stem-cell-like than granule cell precursors, which may represent a more restricted precursor cell...
  68. ncbi The role of NMDAR subtypes and charge transfer during hippocampal LTP induction
    Sven Berberich
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuropharmacology 52:77-86. 2007
    ..Thus, at least for LFS pairing, the amount of charge transfer, and thus Ca2+ influx, during LTP induction is a factor more critical than the participation of a particular NMDAR subtype...
  69. pmc Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning
    S Hatazaki
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Neuroscience 150:467-77. 2007
    ..The present study defines a paradigm for inducing epileptic preconditioning in mice and first insight into the global transcriptome of the seizure-damage refractory brain...
  70. ncbi Activation of Ih is necessary for patterning of mGluR and mAChR induced network activity in the hippocampal CA3 region
    S R Cobb
    Division of Neuroscience and Biomedical Systems, University of Glasgow, Glasgow, G12 8QQ, UK
    Neuropharmacology 44:293-303. 2003
    ..These data support the idea that the I(h) pacemaker current is important in the generation of patterned neuronal activities in the hippocampus...
  71. doi The spatiotemporal pattern of somal and axonal pathology after perikaryal excitotoxic injury to retinal ganglion cells: a histological and morphometric study
    S K Saggu
    Department of Ophthalmology and Visual Sciences, The University of Adelaide, SA 5000, Australia
    Exp Neurol 211:52-8. 2008
    ..To describe the spatiotemporal pattern of somal and axonal pathologic changes after perikaryal excitotoxic injury to retinal ganglion cells in-vivo...
  72. doi Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition
    Chantal Schlumberger
    Department of In Vivo Pharmacology, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany
    Behav Pharmacol 20:56-66. 2009
    ..In conclusion, LY354740 was effective in models for anxiety and positive symptoms of schizophrenia but not in models for sensorimotor gating and cognitive impairment...
  73. ncbi NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153
    Maiko Awai
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    J Neurochem 96:43-52. 2006
    ..In conclusion, CHOP is induced in mouse retina by NMDA treatment, and CHOP/ mice are more resistant to NMDA-induced retinal damage, suggesting that CHOP plays an important role in NMDA-induced retinal cell death...
  74. ncbi The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials
    De Maw Chuang
    Molecular Neurobiology Section, Biological Psychiatry Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1363, USA
    Ann N Y Acad Sci 1053:195-204. 2005
    ..Thus, lithium and valproate are potential drugs for treating some forms of neurodegenerative diseases...
  75. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    Peter V Massey
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:7821-8. 2004
    ..Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex...
  76. ncbi Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    Lingfei Hou
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:6352-61. 2004
    ..Together, our findings indicate that activation of the PI3K-Akt-mTOR signaling cascade is required for mGluR-LTD and suggest that this pathway may couple group I mGluRs to translation initiation in hippocampal area CA1...
  77. pmc NR2B-containing receptors mediate cross talk among hippocampal synapses
    Annalisa Scimemi
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 24:4767-77. 2004
    ..These NMDAR isoforms thus play complementary roles in sensing global and local glutamate signals, respectively...
  78. ncbi Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus
    Helen L Alderson
    School of Psychology, St Andrews University, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
    Eur J Neurosci 23:2169-75. 2006
    ..The resulting change in nicotine self-administration behaviour was hypothesized to reflect either a reduction in intrinsic nicotine reward value, or enhancement of associative incentive salience...
  79. ncbi Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors
    Patrick J Mueller
    Department of Biomedical Sciences, Dalton Cardiovascular Research Center, 134 Research Park, University of Missouri, Columbia, MO 65211 3300, USA
    Am J Physiol Regul Integr Comp Physiol 289:R198-208. 2005
    ..Thus we conclude that responses to L-AP4 in the NTS are mediated by an interaction between group III mGluRs and NMDA receptors. Finally, we also caution that nonselective actions of L-AP4 should be considered in future studies...
  80. ncbi Group III metabotropic glutamate receptors and exocytosed protons inhibit L-type calcium currents in cones but not in rods
    Nobutake Hosoi
    Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 25:4062-72. 2005
    ..Selective modulation of ICa in cones may help broaden the dynamic range of synaptic transfer by controlling the amount of transmitter release from cones...
  81. ncbi Kainic acid-mediated excitotoxicity as a model for neurodegeneration
    Qun Wang
    Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Neurobiol 31:3-16. 2005
    ..The focus of this review is to summarize studies demonstrating KA-induced excitotoxicity in the central nervous system and possible intervention by anti-oxidants...
  82. ncbi Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation
    Dongni Yang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
    Pain 106:411-7. 2003
    ....
  83. ncbi Spontaneous recurrent network activity in organotypic rat hippocampal slices
    Majid H Mohajerani
    Neuroscience Program, International School for Advanced Studies, Via Beirut 2 4, 34014 Trieste, Italy
    Eur J Neurosci 22:107-18. 2005
    ..This was in line with the transient bicuculline-induced block of GDPs and with the isoguvacine-induced increase of GDP frequency...
  84. ncbi Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 29:300-7. 2004
    ..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia...
  85. ncbi Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate
    Jerome Jourquin
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, CNRS FRE 2533 IFR Jean Roche Université de la Méditerranée Faculté de Médecine de Marseille, 27 Bd Jean Moulin 13385, Marseille Cedex 05, France
    Eur J Neurosci 18:1507-17. 2003
    ....
  86. ncbi Fragmented DNA transport in dendrites of retinal neurons during apoptotic cell death
    Akira Hara
    Department of Tumor Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Brain Res 1007:183-7. 2004
    ..The transport of fragmented DNA, but not fragmentation per se, was completely inhibited by the co-administration of vincristine...
  87. ncbi Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats
    W Yuan
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa 33612 4799, USA
    Neuroscience 114:1091-101. 2002
    ..The observed ADAMTS-induced cleavage of brevican in the dentate outer molecular layer is closely associated with diminished synaptic density, and may, therefore, contribute to synaptic loss and/or reorganization in this region...
  88. pmc A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices
    A J Doherty
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD
    Br J Pharmacol 131:239-44. 2000
    ..6. These results further indicate that mGlu receptor-mediated potentiation of NMDA responses is not essential for the induction of LTP...
  89. pmc Modulation of the glycine response by Ca2+-permeable AMPA receptors in rat spinal neurones
    T L Xu
    Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 514:701-11. 1999
    ..This interaction may provide a new postsynaptic mechanism for control of inhibitory synaptic signalling and represent one of the important regulatory mechanisms of spinal nociception...
  90. pmc mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones
    Lisa Topolnik
    Departement de Physiologie, Centre de Recherche en Sciences Neurologiques, Universite de Montreal, Case Postale 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    J Physiol 575:115-31. 2006
    ..Thus, our findings uncover a novel molecular mechanism of interneurone-specific Ca2+ signalling, critical in regulating synaptic excitability in hippocampal networks...
  91. pmc Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2
    K A Kelley
    Neuroinflammation Research Laboratories, Department of Psychiatry, Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York, USA
    Am J Pathol 155:995-1004. 1999
    ..This model system will allow the systematic examination of the role of COX-2 in mechanisms of neurodegeneration that involve excitatory amino acid pathways...
  92. ncbi Alcohol blocks TNFalpha but not other cytokine-mediated neuroprotection to NMDA
    L C Gahring
    Salt Lake City Veterans Administration Medical Center, Department of Medicine, University of Utah School of Medicine, 84112 5330, USA
    Alcohol Clin Exp Res 23:1571-9. 1999
    ..We have investigated the effects of ethanol/alcohol (ETOH) on the pro-inflammatory CNS cytokine network that mediates neuroprotection to an excitotoxic challenge with the glutamate receptor agonist N-methyl-D-aspartic acid (NMDA)...
  93. ncbi Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxia
    Agnieszka Nadlewska
    Department of Pharmacology, Medical Academy, Białystok, Poland
    Pol J Pharmacol 54:11-8. 2002
    ..In rats subjected to hypoxia, (S)-3,5-DHPG, the agonist of I mGluRs, improved consolidation and retrieval and exhibited anxiolytic activity in dose-dependent manner...
  94. ncbi Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells
    Zare Melyan
    Centre for Neuroscience, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Neuron 34:107-14. 2002
    ..These data suggest how KARs, putatively containing GluR6, directly increase excitability of CA1 pyramidal cells and help explain the propensity for seizure activity following KAR activation...
  95. ncbi Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway
    Jon Nilsen
    Department of Molecular Pharmacology and Toxicology, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Brain Res 930:216-34. 2002
    ..These data provide potential mechanisms to explain the cognitive enhancing and neuroprotective effects exerted by ERT...
  96. ncbi Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy
    Bret N Smith
    Department of Anatomy and Neurobiology, Program in Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA
    J Neurophysiol 87:1655-8. 2002
    ..These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus...
  97. ncbi Enhanced taurine release in cultured cerebellar granule cells in cell-damaging conditions
    P Saransaari
    Tampere Brain Research Center, University of Tampere Medical School, Finland
    Amino Acids 17:323-34. 1999
    ..The prolonged taurine release seen in both normoxia and cell-damaging conditions may be of importance in maintaining homeostasis in the cerebellum and reducing excitability for a longer period than other neuroprotective mechanisms...
  98. ncbi Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death
    J van Beek
    European Institute for Peptide Research IFRMP 23, INSERM U519, Rouen, France
    Neuroreport 12:289-93. 2001
    ..These observations suggest that C3a is involved in excitotoxicity-mediated neuronal death through astrocyte stimulation and extend its role beyond immune functions...
  99. ncbi Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matter
    S Li
    Ottawa Health Research Institute, Division of Neuroscience, Ottawa Hospital, Civic Campus, University of Ottawa, 725 Parkdale Avenue, Ottawa, ON, Canada K1Y 4K9
    Neuroscience 107:675-83. 2001
    ..This mechanism likely plays an important role during ischemic and traumatic white matter injury, where collapse of transmembrane Na(+) and K(+) gradients occurs...
  100. ncbi Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase
    G Fuller
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res Mol Brain Res 89:126-32. 2001
    ..This provides evidence for a novel pathway linking striatal kainate receptors to ERK activation via PI3 kinase and MEK...
  101. ncbi (S)-3,5-DHPG: a review
    Konstanty Wiśniewski
    Department of Pharmacology, Medical Academy, 15 222 Bialystok, Mickiewicza 2c, Poland
    CNS Drug Rev 8:101-16. 2002
    ..S)-3,5-DHPG may be useful as a cognitive enhancing agent in memory impairment associated with ischemia or hypoxia. Recent investigations suggested possible beneficial effects of (S)-3,5-DHPG in Alzheimer's disease...

Research Grants68

  1. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ....
  2. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 1993
    ..3. The potential role of nitric oxide (NO) in the effects of glutamate and excitatory amino acid agonists on transmitter release will be determined...
  3. D-Cycloserine Facilitation of Cocaine-Cue Extinction
    KATHLEEN THERESA BRADY; Fiscal Year: 2010
    ..New treatments are needed for cocaine dependence. Cocaine-related environmental cues are likely to be involved in relapse. In this study, an innovative pharmacologic approach to decreasing the response to cocaine cues will be tested. ..
  4. D-Cycloserine Facilitation of Cocaine-Cue Extinction
    Kathleen Brady; Fiscal Year: 2009
    ..New treatments are needed for cocaine dependence. Cocaine-related environmental cues are likely to be involved in relapse. In this study, an innovative pharmacologic approach to decreasing the response to cocaine cues will be tested. ..
  5. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    SHARON KUJAWA; Fiscal Year: 2009
    ..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
  6. VISION AND INTRARETINAL POTENTIALS
    DWIGHT BURKHARDT; Fiscal Year: 1993
    ..Other experiments will analyze membrane potential, temporal resolution, voltage-sensitive mechanisms and pigment regeneration during dark adaptation...
  7. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    SHARON KUJAWA; Fiscal Year: 2010
    ..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
  8. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    SHARON KUJAWA; Fiscal Year: 2009
    ..Our proposed experiments provide a powerful platform to study the phenomenon and to probe its mechanisms, using a cochlear insult (i.e. noise) that is highly relevant to the human condition. ..
  9. HEROIN AIDS ENCEPHALOPATHY--NEUROPATHOGENESIS MECHANISMS
    Madhavan Nair; Fiscal Year: 2005
    ..We further demonstrated that in vivo stereotaxic injection of HIV proteins plus excitatory amino acid agonists into the dorsal hippocampus of neonatal rat brains causes both gross and microscopic neuropathology...
  10. IONIC MECHANISM OF EXCITATORY AMINO ACIDS
    JOHN HABLITZ; Fiscal Year: 1993
    ..preparations by examining intracellularly recorded EPSPs and responses to iontophoretically applied excitatory amino acid agonists. Studies on cultured rat neocortical neurons will determine the mechanism underlying the biphasic ..
  11. Use of Novel Cox-2 Inhibitors in Neurological Disorders
    STANLEY BELL; Fiscal Year: 2006
    ....
  12. AIDS encephalopathy and HIV disease: role of opioids
    Madhavan Nair; Fiscal Year: 2006
    ..We further demonstrated that in vivo stereotaxic injection of HIV proteins plus excitatory amino acid agonists into the dorsal hippocampus of neonatal rat brains causes both gross and microscopic neuropathology...
  13. NMDA RECEPTOR AND BEHAVIORAL TOXICITY OF LEAD
    Deborah Cory Slechta; Fiscal Year: 1993
    ....
  14. DOPAMINE SYSTEM INTERACTIONS AND SCHIZOPHRENIA
    ARIEL DEUTCH; Fiscal Year: 2004
    ..of the NAS and PFC DA innervations to agents that evoke DA release (KC1 and amphetamine) and to excitatory amino acid agonists (NMDA and AMPA)...
  15. Mechanisms of Secondary Damage after Spinal Cord Injury
    JACQUELINE BRESNAHAN; Fiscal Year: 2009
    ..These studies should provide evidence to test whether this novel interaction between a cytokine and a neurotransmitter may be involved in the exacerbation of secondary injury following SCI. If so, it may be a new target for therapies. ..