muscarinic agonists

Summary

Summary: Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.

Top Publications

  1. ncbi Cholinergic inhibition of neocortical pyramidal neurons
    Allan T Gulledge
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Neurosci 25:10308-20. 2005
  2. doi A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight
    Edgar Buhl
    University of Leipzig, Institute of Biology II, Talstr 33, 04103 Leipzig, Germany
    J Exp Biol 211:2346-57. 2008
  3. ncbi Muscarinic agonists for the treatment of cognition in schizophrenia
    Angela K Sellin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    CNS Spectr 13:985-96. 2008
  4. doi FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors
    Nicole Ziegler
    Department of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Str 9, 97078 Wuerzburg, Germany
    Bioorg Med Chem 19:1048-54. 2011
  5. pmc Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate
    Byung Chang Suh
    Department of Physiology and Biophysics, The University of Washington School of Medicine, Seattle, WA 98195 7290, USA
    Neuron 67:224-38. 2010
  6. ncbi Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells
    D Mears
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Membr Biol 197:59-70. 2004
  7. doi Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease
    Abraham Fisher
    Israel Institute for Biological Research, PO Box 19, Ness Ziona, Israel
    Neurotherapeutics 5:433-42. 2008
  8. ncbi Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
    R Cossart
    INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
    Nat Neurosci 4:52-62. 2001
  9. ncbi Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling
    Yuko Fukudome
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Eur J Neurosci 19:2682-92. 2004
  10. ncbi Muscarine reduces calcium-dependent electrical activity in substantia nigra dopaminergic neurons
    R S Scroggs
    Department of Anatomy and Neurobiology, Health Science Center, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurophysiol 86:2966-72. 2001

Detail Information

Publications287 found, 100 shown here

  1. ncbi Cholinergic inhibition of neocortical pyramidal neurons
    Allan T Gulledge
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Neurosci 25:10308-20. 2005
    ..These data demonstrate that acetylcholine can directly inhibit the output of neocortical pyramidal neurons...
  2. doi A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight
    Edgar Buhl
    University of Leipzig, Institute of Biology II, Talstr 33, 04103 Leipzig, Germany
    J Exp Biol 211:2346-57. 2008
    ....
  3. ncbi Muscarinic agonists for the treatment of cognition in schizophrenia
    Angela K Sellin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    CNS Spectr 13:985-96. 2008
    ..We present an overview of likely side effects of muscarinic agonists. We outline the anticholinergic activity of several available antipsychotics and review the available M1 ..
  4. doi FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors
    Nicole Ziegler
    Department of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Str 9, 97078 Wuerzburg, Germany
    Bioorg Med Chem 19:1048-54. 2011
    ..Taken together our data support the notion that orthosteric agonists behave similar at different muscarinic receptor subtypes but that kinetic differences can be observed for receptor activation...
  5. pmc Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate
    Byung Chang Suh
    Department of Physiology and Biophysics, The University of Washington School of Medicine, Seattle, WA 98195 7290, USA
    Neuron 67:224-38. 2010
    ..Thus, endogenous membrane PIP(2) supports high-voltage activated L-, N-, and P/Q-type Ca(2+) channels, and stimuli that activate phospholipase C deplete PIP(2) and reduce those Ca(2+) channel currents...
  6. ncbi Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells
    D Mears
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Membr Biol 197:59-70. 2004
    ..We conclude that I(musc) consists of store-operated and store-independent components, both of which may contribute to the depolarizing action of muscarinic agonists on pancreatic beta-cells.
  7. doi Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease
    Abraham Fisher
    Israel Institute for Biological Research, PO Box 19, Ness Ziona, Israel
    Neurotherapeutics 5:433-42. 2008
    ..the advantages and drawbacks of some cholinergic compounds, such as acetylcholinesterase inhibitors, M1 muscarinic agonists, M2 antagonists, and nicotinic agonists...
  8. ncbi Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
    R Cossart
    INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
    Nat Neurosci 4:52-62. 2001
    ..A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity...
  9. ncbi Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling
    Yuko Fukudome
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Eur J Neurosci 19:2682-92. 2004
    ..Thus, the muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms...
  10. ncbi Muscarine reduces calcium-dependent electrical activity in substantia nigra dopaminergic neurons
    R S Scroggs
    Department of Anatomy and Neurobiology, Health Science Center, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurophysiol 86:2966-72. 2001
    ....
  11. pmc Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels
    Katherine A Buchanan
    Medical Research Council Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuron 68:948-63. 2010
    ..Thus, we describe a mechanism where M(1) receptor activation inhibits SK channels, allowing enhanced NMDAR activity and leading to a facilitation of LTP induction in the hippocampus...
  12. pmc Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists
    A Kanai
    Department of Medicine, University of Pittsburgh School of Medicine, A1224 Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 292:F1065-72. 2007
    ..the origin of spontaneous activity in neonatal and adult rat bladders and the effect of stretch and muscarinic agonists and antagonists on spontaneous activity...
  13. ncbi Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    Jurgen Wess
    Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0810, USA
    Nat Rev Drug Discov 6:721-33. 2007
    ..Importantly, these studies have identified specific mAChR-regulated pathways as potentially novel targets for the treatment of various important disorders including Alzheimer's disease, schizophrenia, pain, obesity and diabetes...
  14. doi Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands
    Fred R Burlage
    Department of Radiation Oncology, University Medical Center Groningen, The Netherlands
    Radiother Oncol 90:253-6. 2009
    ..In this study, this hypothesis is tested directly, by assessing the proliferation of progenitor and secretory cells in irradiated and non-irradiated parotid gland tissue...
  15. pmc Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn
    H Baba
    Department of Anaesthesiology, Niigata University School of Medicine, Niigata 951, Japan
    J Physiol 508:83-93. 1998
    ..Those effects may be responsible for the antinociceptive action produced by the intrathecal administration of muscarinic agonists and acetylcholinesterase inhibitors.
  16. ncbi Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications
    Jurgen Wess
    Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, DHHS, Bethesda, Maryland 20892, USA
    Annu Rev Pharmacol Toxicol 44:423-50. 2004
    ..The novel insights gained from these studies should prove instrumental for the development of novel classes of muscarinic drugs...
  17. pmc Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala
    Ryan T Lalumiere
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Learn Mem 12:527-32. 2005
    ..Additionally, these findings indicate that the enhancement, but not impairment, of memory consolidation is lateralized to the right BLA...
  18. pmc Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists
    G Akk
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York, NY 14214, USA
    Br J Pharmacol 128:1467-76. 1999
    ..The results are discussed in terms of structure-function relationships at the nAChR transmitter binding site...
  19. ncbi AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease
    Abraham Fisher
    Israel Institute for Biological Research, Ness Ziona
    J Mol Neurosci 19:145-53. 2002
    The M1 muscarinic agonists AF102B (Cevimeline, EVOXACTM: prescribed in USA and Japan for Sjogren's Syndrome), AF150(S) and AF267B--1) are neurotrophic and synergistic with neurotrophins such as nerve growth factor and epidermal growth ..
  20. doi Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro
    Alexey Kuzmenkin
    Institute for Neurophysiology, Medical Center, University of Cologne, Cologne, Germany
    FASEB J 23:4168-80. 2009
    ..This difference may reflect the incomplete reprogramming of iPS cells and should be critically considered in further studies to clarify the suitability of the iPS model for regenerative medicine of heart disorders...
  21. ncbi Influence of muscarinic agonists and tyrosine kinase inhibitors on L-type Ca(2+)Channels in human and bovine trabecular meshwork cells
    K Steinhausen
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, Berlin, 12200, Germany
    Exp Eye Res 70:285-93. 2000
    ..The activity of L-type Ca(2+)currents is influenced by muscarinic agonists and tyrosine kinases.
  22. ncbi Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis
    Byung Chang Suh
    Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Neuron 35:507-20. 2002
    ..Lipid phosphorylation by PI 4-kinase is required for recovery from muscarinic modulation of M current...
  23. ncbi Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current
    M S Shapiro
    Department of Physiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 20:1710-21. 2000
    ..The M current is modulated by muscarinic agonists via G-proteins and an unidentified diffusible cytoplasmic messenger...
  24. ncbi Importance and prospects for design of selective muscarinic agonists
    J Jakubik
    Department of Neurochemistry, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:S39-47. 2008
    ..The selectivity of classical muscarinic agonists among receptor subtypes is very low due to the highly conserved nature of the orthosteric binding site ..
  25. pmc Muscarinic modulation of erg potassium current
    Wiebke Hirdes
    Department of Physiology and Biophysics, University of Washington School of Medicine, G 424 Health Sciences Building, Box 357290, Seattle, WA 98195 7290, USA
    J Physiol 559:67-84. 2004
    ..Wortmannin did not prevent muscarinic inhibition. Our studies of muscarinic inhibition of erg current suggest a role for phospholipase C, but not the classical downstream messengers, such as PKC or a calcium transient...
  26. doi M1 muscarinic agonists target major hallmarks of Alzheimer's disease--the pivotal role of brain M1 receptors
    Abraham Fisher
    Israel Institute for Biological Research, Ness Ziona, Israel
    Neurodegener Dis 5:237-40. 2008
    ..M1 muscarinic receptor (M1 mAChR) is a therapeutic target in Alzheimer's disease (AD) and the M1-selective muscarinic agonists AF102B, AF150(S) and AF267B are cognitive enhancers and potential disease modifiers...
  27. ncbi Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system
    Steven M Finney
    Western General Hospital, Edinburgh, Scotland, UK
    BJU Int 100:668-78. 2007
    To analyse pressure changes induced by muscarinic agonists on the isolated bladder in order to examine whether there are different responses representing different components of a motor/sensory system within the bladder wall.
  28. ncbi Inhibitory actions of calcitonin gene-related peptide and capsaicin: evidence for local axonal reflexes in the bladder wall
    James I Gillespie
    The Urophysiology Research Group, School of Surgical and Reproductive Sciences, The Medical School, The University, Newcastle upon Tyne NE2 4HH, UK
    BJU Int 95:149-56. 2005
    ....
  29. ncbi Thoracic leg motoneurons in the isolated CNS of adult Manduca produce patterned activity in response to pilocarpine, which is distinct from that produced in larvae
    Rebecca M Johnston
    Department of Neurobiology, University of Arizona, Tucson AZ 85721 0077, USA
    Invert Neurosci 4:175-92. 2002
    ..Nevertheless, the basic similarity to adult walking and clear distinctions from the larval fictive crawling pattern suggest that changes within the CNS contribute to alterations in locomotor activity during metamorphosis...
  30. pmc Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: evidence for a non-DNA target of radiation
    R P Coppes
    Department of Radiation and Stress Cell Biology, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Br J Cancer 92:539-46. 2005
    ..To the best of our knowledge, these data for the first time suggest that, the cells' capacity to respond to a receptor agonist is impaired after irradiation...
  31. ncbi A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism
    Mark R Dowling
    Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University of Leicester, University Road, Leicester, LE1 9HN, UK
    J Pharmacol Exp Ther 317:1134-42. 2006
    ....
  32. doi Presynaptic muscarinic receptor subtypes involved in the enhancement of spontaneous GABAergic postsynaptic currents in hippocampal neurons
    J C Gonzalez
    Instituto Teofilo Hernando, IIS Hospital Universitario de la Princesa, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Eur J Neurosci 33:69-81. 2011
    ....
  33. pmc No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea
    A F Roffel
    Groningen Utrecht Institute for Drug Exploration, Department of Medicinal Chemistry and Molecular Pharmacology, University of Groningen, The Netherlands
    Br J Pharmacol 115:665-71. 1995
    ..Furthermore,they stress the importance of taking into account non-cholinergic controls as well as contraction levels in these experiments...
  34. ncbi Role of dopamine D1 receptors in the striatal and cortical fos expression induced by the muscarinic agonist pilocarpine
    David Wirtshafter
    Laboratory of Integrative Neuroscience, Department of Psychology, University of Illinois at Chicago, 1007 West Harrison, Chicago, IL 60607 7137, USA
    Eur J Pharmacol 488:85-90. 2004
    ..75-3.00 mg/kg) virtually abolished the Fos response at both sites. These results suggest that stimulation of dopamine D1 receptors may mediate the effects of muscarinic agonists on Fos expression in the striatum, but not the cortex.
  35. ncbi Distinct muscarinic receptors enhance spontaneous GABA release and inhibit electrically evoked GABAergic synaptic transmission in the chick lateral spiriform nucleus
    J Guo
    Department of Pharmacology, School of Medicine and Health Sciences, The George Washington University, 2300 Eye Street N W, Washington, DC 20037, USA
    Neuroscience 104:1057-66. 2001
    The effects of muscarinic agonists on GABAergic synaptic transmission were examined using whole-cell patch-clamp recording in chick brain slices containing the lateral spiriform nucleus...
  36. ncbi The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder
    Frederick J Ehlert
    Department of Pharmacology, College of Medicine, University of California Irvine, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 313:368-78. 2005
    ..We also show that it is difficult to detect M2 receptor function in competitive antagonism studies under conditions where a simultaneous activation of M2 and M3 receptors occurs...
  37. ncbi Salivary gland dysfunction: a review of systemic therapies
    M M Grisius
    Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia 19104 6003, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:156-62. 2001
    ..The aim of this article is to briefly review salivary gland physiology and to summarize the suggested systemic treatment modalities for xerostomia that emphasize controlled clinical trials...
  38. ncbi Preemptive pharmacologic intervention in radiation-induced salivary dysfunction
    S E Taylor
    Department of Oral and Maxillofacial Surgery and Pharmacology, Baylor College of Dentistry The Texas A and M University System, Dallas, Texas 75246, USA
    Proc Soc Exp Biol Med 221:14-26. 1999
    ..Finally, we describe encouraging results from early clinical trials suggesting that protection of salivary glands during therapeutic irradiation may be possible...
  39. pmc Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus
    Katherine W Falenski
    Department of Neurology, Virginia Commonwealth University, PO Box 980599, Richmond, VA 23298, USA
    Brain Res 1262:64-72. 2009
    ..This suggests a role for dysregulation of the endocannabinoid system during epileptogenesis and indicates that the CB(1) receptor redistribution temporally correlates with the emergence of epileptic seizures...
  40. pmc Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity
    Joy E Marlo
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Mol Pharmacol 75:577-88. 2009
    ..These data also suggest that structurally diverse M(1) potentiators may act by distinct mechanisms and differentially regulate receptor coupling to downstream signaling pathways...
  41. ncbi Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor
    Carl P Nelson
    Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE1 9HN, UK
    J Pharmacol Exp Ther 316:279-88. 2006
    ..This indicates that the N410Y mutation of the M(2) mACh receptor alters receptor-G-protein coupling in an agonist-dependent manner, in addition to generating a constitutively active receptor phenotype...
  42. ncbi The effects of tertiapin-Q on responses of the sinoatrial pacemaker of the guinea-pig heart to vagal nerve stimulation and muscarinic agonists
    Chris P Bolter
    Department of Physiology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Exp Physiol 93:53-63. 2008
    ..IK,ACh, in the bradycardia produced by electrical stimulation of the vagus (parasympathetic) nerve and muscarinic agonists (ACh and bethanecol, bolus i.a.)...
  43. pmc Dual effects of muscarinic M(2) acetylcholine receptors on the synthesis of cyclic AMP in CHO cells: dependence on time, receptor density and receptor agonists
    P Michal
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic
    Br J Pharmacol 132:1217-28. 2001
    ..It tends to be abolished by receptor internalization...
  44. ncbi AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
    Naoto Hoshi
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Nat Neurosci 6:564-71. 2003
    ..These inhibitors also reduced muscarinic inhibition of M-current. Our data indicate that AKAP150-bound PKC participates in receptor-induced inhibition of the M-current...
  45. pmc Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells
    H E Scharfman
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
    Neuroscience 104:741-59. 2001
    ..The fact that mossy cells have epileptiform bursts, and that they are synchronized with area CA3, suggest a previously unappreciated substrate for hyperexcitability in this animal model...
  46. ncbi Cholinergic control of firing pattern and neurotransmission in rat neostriatal projection neurons: role of CaV2.1 and CaV2.2 Ca2+ channels
    Tamara Perez-Rosello
    Departamento de Biofisica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City DF, Mexico
    J Neurophysiol 93:2507-19. 2005
    ..Together, both effects would tend to recruit more spiny neurons for the same task...
  47. ncbi Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists
    Joseph I Friedman
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    Psychopharmacology (Berl) 174:45-53. 2004
    ..Therefore, pharmacological treatments that enhance central cholinergic function may be useful as cognitive enhancers in schizophrenia...
  48. ncbi Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate
    Yang Li
    Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 25:9825-35. 2005
    ..Divergent apparent affinities of Kv7.2-7.4 channels for PIP2 may underlie their highly differential maximal Po observed in cell-attached patches...
  49. ncbi New insights from the use of pilocarpine and kainate models
    J P Leite
    Department of Neurology, University of São Paulo School of Medicine at Ribeirão Preto, Campus Universitario, Ribeirao Preto, Brazil
    Epilepsy Res 50:93-103. 2002
    ..Most of current tools used to quantify spontaneous seizure events need to be coupled to electrophysiology and more sophisticated systems for recording and analyzing behavior...
  50. pmc Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
    P Jeffrey Conn
    Department of Pharmacology, Vanderbilt Program in Drug Discovery, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Trends Pharmacol Sci 30:148-55. 2009
    ....
  51. ncbi In vivo and in vitro effects of pilocarpine: relevance to ictogenesis
    Nicola Marchi
    Department of Cerebrovascular Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:1934-46. 2007
    ..The extent of such peripheral events and the contribution to SE are unknown and the possibility that pilocarpine also induces SE by peripheral actions is yet untested...
  52. ncbi Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors
    Jan Jakubik
    Department of Neurochemistry, Institute of Physiology CAS, Videnska 1083, 14220 Prague, Czech Republic
    Mol Pharmacol 70:656-66. 2006
    ..These conformations are both time- and concentration-dependent and vary between the M(1) and the M(2) receptor...
  53. pmc Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder
    K J Pak
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697 4625, USA
    Naunyn Schmiedebergs Arch Pharmacol 381:441-54. 2010
    ..M2 receptor activation opposes forskolin-induced relaxation of the urinary bladder, and this M(2) function is enhanced following streptozotocin treatment...
  54. ncbi Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay
    N W Delapp
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 289:946-55. 1999
    ..Antibody capture GTPgamma35S binding using scintillation proximity assay technology provides a convenient, productive alternative to immunoprecipitation for exploration of receptor-G protein interaction in cells and tissues...
  55. doi Muscarinic agonists acting through M2 acetylcholine receptors stimulate the migration of an NO-sensitive guanylyl cyclase to the plasma membrane of bovine tracheal smooth muscle
    Fabiola Pláceres Uray
    Sección de Biomembranas, Instituto de Medicina Experimental, Cátedra de Patología General y Fisiopatología, Escuela Luis Razetti, Facultad de Medicina Universidad Central de Venezuela, Caracas, Venezuela
    J Recept Signal Transduct Res 30:10-23. 2010
    b>Muscarinic agonists acting on bovine tracheal smooth muscle (BTSM) induce two separate cGMP signals, one at 20 sec associated with NO-sensitive-soluble-guanylyl-cyclase (NO-sGC) and another at 60 sec, linked to natriuretic-peptide-GC...
  56. ncbi Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex
    Kayla C De Lorme
    Division of Neuroscience Research in Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Pharmacol Exp Ther 323:868-76. 2007
    ..Our results imply that brief exposure to xanomeline followed by washing and prolonged waiting may result in delayed receptor desensitization accompanied by internalization or down-regulation...
  57. ncbi Gender comparison of muscarinic receptor expression and function in rat and human urinary bladder: differential regulation of M2 and M3 receptors?
    Christian Kories
    Department of Medicine, University of Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 367:524-31. 2003
    ....
  58. ncbi Identification of a ligand-dependent switch within a muscarinic receptor
    T A Spalding
    ACADIA Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 273:21563-8. 1998
    ..These results suggest that TM6 is a switch that defines the activation state of the receptor, and that ligand interactions with TM6 stabilize the receptor in either an active or an inactive conformation...
  59. ncbi Pilocarpine prevents age-related spatial learning impairments in rats
    Nelson De-Mello
    Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Campus Universitario Trindade, 88049 900 Florianopolis, SC, Brazil
    Behav Brain Res 158:263-8. 2005
    ..These results indicate that a single administration of Pilo might prevent the age-related learning impairments in rats on a spatial task in the water maze...
  60. ncbi Imaging of muscarinic acetylcholine receptor signaling in hippocampal neurons: evidence for phosphorylation-dependent and -independent regulation by G-protein-coupled receptor kinases
    Jonathon M Willets
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Neurosci 24:4157-62. 2004
    ..Together, our data suggest a role for both phosphorylation-dependent and -independent regulation of M1 mACh receptors in hippocampal neurons...
  61. ncbi Muscarinic acetylcholine receptors as CNS drug targets
    Christopher J Langmead
    Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex, CM19 5AW, UK
    Pharmacol Ther 117:232-43. 2008
    ....
  62. doi Activation of the cholinergic system endows compositional properties to striatal cell assemblies
    Luis Carrillo-Reid
    Departamento de Biofisica, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México UNAM PO Box 70 253, Mexico City, DF 04510 Mexico
    J Neurophysiol 101:737-49. 2009
    ..Neuronal recurrent networks with the characteristics encountered in the present experiments are proposed to allow repeated sequences of activity to become memories and repeated memories to compose learned motor procedures...
  63. pmc Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice
    M Yamada
    Laboratory of Bioorganic Chemistry National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:14096-101. 2001
    ....
  64. ncbi Homologous mutations near the junction of the sixth transmembrane domain and the third extracellular loop lead to constitutive activity and enhanced agonist affinity at all muscarinic receptor subtypes
    Diane J Ford
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Pharmacol Exp Ther 300:810-7. 2002
    ..Based on the results of the present study, it is possible that TM6 represents a general switch for the activation of the muscarinic receptor family...
  65. ncbi Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
    Karolien Goffin
    Katholieke Universiteit Leuven, Leuven, Belgium
    Exp Neurol 205:501-5. 2007
    ..Finally, our data suggest that the model can be used for studies aiming at identifying the mechanisms of seizure clustering...
  66. ncbi Diabetes mellitus and responses of the urinary bladder to acetylcholine: an in vitro study
    Abdon M Nsabimana
    Department of Pharmacology, School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu Natal, Durban, South Africa
    J Smooth Muscle Res 44:143-50. 2008
    ..on the responses of diabetic bladder strips to cholinergic nerve stimulation or exogenously-administered muscarinic agonists, especially acetylcholine (ACh)...
  67. ncbi Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor
    Jan Jakubik
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Pharmacol Exp Ther 301:1033-41. 2002
    ..Our findings are best interpreted in terms of allosteric interactions between xanomeline-persistent binding to the M(1) muscarinic receptor and competitive ligands bound to the classical receptor binding site...
  68. pmc Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells
    Takashi Sakamoto
    Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Physiol 582:41-61. 2007
    ..The delineation of this pathway is consistent with the formation of a functional unit by the M2-Go protein and the M3-PLC systems predicted to control cationic channels...
  69. pmc Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1
    C J Langmead
    Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, UK
    Br J Pharmacol 154:1104-15. 2008
    ..However, studies with this compound have been limited to recombinantly expressed mAChRs...
  70. ncbi Discovery of an ectopic activation site on the M(1) muscarinic receptor
    Tracy A Spalding
    ACADIA Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Pharmacol 61:1297-302. 2002
    ....
  71. ncbi Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase
    Jasmina Minic
    Institut Fédératif de Neurobiologie Alfred Fessard, Laboratoire de Neurobiologie Cellulaire et Moleculaire, C N R S, U P R 9040, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Eur J Neurosci 15:439-48. 2002
    ....
  72. doi Insulin, IGF-1, and muscarinic agonists modulate schizophrenia-associated genes in human neuroblastoma cells
    C Anthony Altar
    Psychiatric Genomics, Inc, Gaithersburg, Maryland, USA
    Biol Psychiatry 64:1077-87. 2008
    ..We determined with human SH-SY5Y neuroblastoma and astrocyte cell lines whether insulin or other molecules could modulate genes opposite to their change reported in schizophrenia brain...
  73. ncbi Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons
    John M Power
    Division of Neuroscience, John Curtin School for Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Neurosci 22:3454-62. 2002
    ..Because rises in nuclear calcium are known to initiate the transcription of novel genes, we suggest that these actions of cholinergic stimulation may underlie its effects on learning and memory...
  74. ncbi Effects of Ba-Wei-Die-Huang-Wan on the cholinergic function and protein expression of M2 muscarinic receptor of the urinary bladder in diabetic rats
    Yat Ching Tong
    Department of Urology, College of Medicine, National Cheng Kung University, Tainan City, 70101, Taiwan, ROC
    Neurosci Lett 330:21-4. 2002
    ..In conclusion, there was an over-expression of M(2) receptor resulting in hyper-contractility in the bladder of diabetic rats. Ba-Wei-Die-Huang-Wan significantly alleviated the alterations...
  75. ncbi Muscarinic agonist-mediated heterologous desensitization in isolated ileum requires activation of both muscarinic M2 and M3 receptors
    Michael T Griffin
    Department of Physical Sciences, Chapman University, Orange, California, USA
    J Pharmacol Exp Ther 308:339-49. 2004
    ....
  76. ncbi Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder
    L A Stevens
    Biomedical Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK
    Auton Autacoid Pharmacol 26:303-9. 2006
    1 Bladder smooth muscle sensitivity to muscarinic agonists is increased in the overactive bladder...
  77. ncbi Assessment of the progressive nature of cell damage in the pilocarpine model of epilepsy
    L Covolan
    Departamento de Fisiologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 39:915-24. 2006
    ..As a consequence of both mechanisms, subsequent insults after an initial insult result in very little damage regardless of their intensity...
  78. ncbi A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
    Dinesh Gautam
    Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Cell Metab 3:449-61. 2006
    ..These findings indicate that beta cell M3 muscarinic receptors play a key role in maintaining proper insulin release and glucose homeostasis...
  79. ncbi Effect of urothelium on bladder contractility in diabetic rats
    Murat Kosan
    Second Urology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
    Int J Urol 12:677-82. 2005
    ..It is known that physiopathological changes in diabetes affect the function of the bladder. In this study, we aimed to demonstrate the possible effects of diabetes on the urothelium during this physiopathological process...
  80. ncbi Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse
    John A Tran
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 318:649-56. 2006
    ..These data suggest a major role for the M3 receptor in eliciting phosphoinositide hydrolysis in the ileum and urinary bladder and minor roles for the M1 and M2 in ileum...
  81. ncbi NMDA-receptor regulation of muscarinic-receptor stimulated inositol 1,4,5-trisphosphate production and protein kinase C activation in single cerebellar granule neurons
    Kenneth W Young
    Department of Cell Physiology and Pharmacology, University of Leicester, Medical Sciences Building, University Road, Leicester LE1 9HN, UK
    J Neurochem 89:1537-46. 2004
    ..Thus, NMDA-mediated Ca2+ influx and PLC activation may represent a coincident-detection system whereby ionotropic and metabotropic signals combine to stimulate InsP(3) production and PKC-mediated phosphorylation events in CGNs...
  82. doi Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor
    Frederick J Ehlert
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 325:1039-60. 2008
    ..If it is assumed that allosterism occurs at the relay site and not the activation site, then this model can account for affinity-only modulation in a manner consistent with the allosteric ternary complex model...
  83. ncbi Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation
    Tracy A Spalding
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121, USA
    Mol Pharmacol 70:1974-83. 2006
    ..crucial role mediating muscarinic acetylcholine receptor activation by acetylcholine, carbachol, and other muscarinic agonists. We compared the effects of point mutations throughout TM3 on the interactions of carbachol, 4-n-butyl-1-[4-..
  84. ncbi Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist
    Christopher J Langmead
    Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Ave, Harlow, Essex, CM19 5AW, UK
    Mol Pharmacol 69:236-46. 2006
    ..These data provide the first direct evidence that AC-42 is an allosteric agonist that activates M(1) receptors in the absence of the orthosteric agonist...
  85. doi Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia
    Anantha Shekhar
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th St, Suite 313, Indianapolis, IN 46202, USA
    Am J Psychiatry 165:1033-9. 2008
    ..The authors studied xanomeline, a relatively selective muscarinic type 1 and type 4 (M(1) and M(4)) receptor agonist, to determine if this agent is effective in the treatment of schizophrenia...
  86. ncbi Role of receptor protein and membrane lipids in xanomeline wash-resistant binding to muscarinic M1 receptors
    Jan Jakubik
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    J Pharmacol Exp Ther 308:105-10. 2004
    ..We suggest that the binding of xanomeline involves interhelical penetration of M1 muscarinic receptor by xanomeline's O-alkyl chain and interaction with membrane lipids surrounding the receptor...
  87. ncbi M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy
    Abraham Fisher
    Israel Institute for Biological Research, 74100 Ness Ziona, Israel
    J Mol Neurosci 20:349-56. 2003
    ..We evaluated the M1 muscarinic agonists AF102B (Cevimeline, EVOXAC trade mark : prescribed for Sjøgren's syndrome), AF150(S), and AF267B on some ..
  88. ncbi Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase
    Nikita Gamper
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Neurosci 23:84-95. 2003
    ..Finally, experiments using cloned KCNQ2/3 channels, Src and M(1) muscarinic receptors, and sympathetic neurons demonstrated that the actions on KCNQ channels by Src and by muscarinic agonists use distinct mechanisms.
  89. pmc Acute induction of epileptiform discharges by pilocarpine in the in vitro isolated guinea-pig brain requires enhancement of blood-brain barrier permeability
    L Uva
    Unit of Experimental Neurophysiology and Epileptology, Fondazione Istituto Neurologico, Via Celoria 11, 20133 Milan, Italy
    Neuroscience 151:303-12. 2008
    ..Pilocarpine accumulation secondary to BBB permeability changes may contribute to in vivo ictogenesis in the pilocarpine epilepsy model...
  90. pmc Long-term wash-resistant effects of brief interaction of xanomeline at the M1 muscarinic receptor
    Kayla C De Lorme
    Division of Neuroscience Research in Psychiatry, University of Minnesota Medical School, Mayo Mail Code 392, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Neurosci Lett 410:11-4. 2006
    ..However, possible involvement of other mechanisms of long-term receptor regulation cannot be discounted...
  91. ncbi Regulation of muscarinic acetylcholine receptor signaling
    Chris J van Koppen
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122, Essen, Germany
    Pharmacol Ther 98:197-220. 2003
    ..In this review, our current understanding of the complex regulatory processes that underlie signaling of mAChR is summarized...
  92. pmc Regulation of bladder muscarinic receptor subtypes by experimental pathologies
    M R Ruggieri
    Department of Urology, Temple University, Philadelphia, PA, USA
    Auton Autacoid Pharmacol 26:311-25. 2006
    ..This finding has substantial implications for the clinical treatment of abnormal bladder contractions...
  93. ncbi On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease
    H J Koch
    University Clinic of Neurology, Universitatsstrasse 84, 93053 Regensburg, Germany
    Curr Med Chem 12:2915-21. 2005
    ..Experimental results postulate a positive long lasting modulation of the pathological neuronal protein pattern in addition to their cholinomimetic effect...
  94. doi G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists
    Rachel L Thomas
    Department of Cell Physiology and Pharmacology, University of Leicester, Room 4 04, Henry Wellcome Building, Lancaster Road, Leicester LE19HN, UK
    J Pharmacol Exp Ther 327:365-74. 2008
    ..77-LH-28-1 (1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone), and a range of orthosteric muscarinic agonists [oxotremorine-M (oxo-M), arecoline, and pilocarpine] in Chinese hamster ovary cells recombinantly ..
  95. ncbi Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons
    Christopher P Ford
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    J Neurosci 23:4931-41. 2003
    ..These are the results that might be expected if agonist-induced activation of PLC and the concomitant depletion of PIP2 contribute to the excitatory action of neurotransmitters that suppress gM...
  96. ncbi Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus
    Takako Ohno-Shosaku
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Eur J Neurosci 18:109-16. 2003
    ..These results indicate that the activation of postsynaptic M1 and M3 receptors facilitates the depolarization-induced release of endocannabinoids...
  97. ncbi Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels
    Joanna S Winks
    1Ion Channel Pharmacology Group, IPC 388, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent CT13 9NJ, United Kingdom
    J Neurosci 25:3400-13. 2005
    ....
  98. ncbi Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists
    A Fisher
    Israel Institute for Biological Research, Ness Ziona
    Jpn J Pharmacol 84:101-12. 2000
    ..The therapeutic potential of M1-selective muscarinic agonists including AF102B, AF150(S), AF267B (the AF series) is evaluated and compared, when possible, with several ..
  99. pmc Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands
    Christopher N Davis
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    BMC Pharmacol 9:14. 2009
    ..The focus of the present study was to determine if M1 receptors activated by allosteric agonists undergo the same regulatory fate as M1 receptors activated by orthosteric agonists...
  100. pmc Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors
    A A Selyanko
    Department of Pharmacology, University College London, UK
    J Physiol 522:349-55. 2000
    ..4. It is concluded that M1 receptors couple to all known KCNQ subunits and that inhibition of KCNQ2 + KCNQ3 channels, like that of native M-channels, requires a diffusible second messenger...
  101. ncbi Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects
    F P Bymaster
    Lilly Neuroscience Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Brain Res 795:179-90. 1998
    ..to stimulate in vivo phosphoinositide (PI) hydrolysis and compared it to a number of direct acting muscarinic agonists, two cholinesterase inhibitors and a putative m1 agonist/muscarinic m2 antagonist...

Research Grants75

  1. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
    ....
  2. Atypical Antipsychotics: Effects on Hepatic Glucose and Lipid Metabolism in Human
    Karen L Teff; Fiscal Year: 2010
    ..Findings from these studies will have important clinical relevance to the treatment of schizophrenia. ..
  3. Atypical Antipsychotics: Effects on Hepatic Glucose and Lipid Metabolism in Human
    Karen Teff; Fiscal Year: 2009
    ..Findings from these studies will have important clinical relevance to the treatment of schizophrenia. ..
  4. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..Results will provide specific information for determination of the dose and temporal administration of agonist in future clinical trials to treat patients with salivary hypofunction. ..
  5. CELLULAR AND MOLECULAR STUDIES OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 2007
    ..The two specific aims of this project are linked in that one drives studies of the the effector pKir2.1 and the second directs studies the msucarinic receptors in the pathway proposed above. ..
  6. The neurogenic potential of cholinergic activation in AD.
    Elizabeth Eckman; Fiscal Year: 2009
    ..Early preliminary data indicate that muscarinic agonists do indeed increase cytogenesis in a manner very similar to that initially observed with D3 agonist ..
  7. The neurogenic potential of cholinergic activation in AD.
    ELIZABETH ADAMS ECKMAN; Fiscal Year: 2010
    ..Early preliminary data indicate that muscarinic agonists do indeed increase cytogenesis in a manner very similar to that initially observed with D3 agonist ..
  8. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 1990
    ..Attainment of these goals will increase our understanding of the effects of lithium that may be related to its therapeutic effect in mania and may generate hypotheses as to the underlying causes of bipolar affective disorders...
  9. CHOLINERGIC MECHANISMS IN AGING AND AD
    LINCOLN POTTER; Fiscal Year: 2002
    ..hemi-PD, but is expected to alter responses to apomorphine (dopamine agonist), pilocarpine and xanomeline (muscarinic agonists). At the least, the results will show whether a specific m1 antagonist can be used to control seizures...
  10. Regulation of Airway Goblet Cell Mucin Secretion
    C Davis; Fiscal Year: 2007
    ..For instance, the effects of muscarinic agonists are highly controversial, there are no data relevant to the mechanisms and pathways underlying the ..
  11. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2007
    ....
  12. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..Our results will also suggest directions for the development of treatments for the decline in mental function that accompanies human aging. ..
  13. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2007
    ..Our results will also suggest directions for the development of treatments for the decline in mental function that accompanies human aging. ..
  14. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    MICHAEL ZHU; Fiscal Year: 2009
    ..In the smooth muscle cells, co-stimulation of M2R and M3R by muscarinic agonists activates a cation current, mICAT...