cysteine proteinase inhibitors

Summary

Summary: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.

Top Publications

  1. ncbi Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity
    X Guo
    Department of Pharmacology, State University of New York, Buffalo, New York 14214, USA
    J Neurobiol 48:120-30. 2001
  2. ncbi Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins
    P van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Mol Biol Cell 12:2556-66. 2001
  3. ncbi Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest
    Xiaotang Hu
    Interdisciplinary Oncology Program, Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 277:16528-37. 2002
  4. ncbi Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response
    L Das
    Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Calcutta, India
    J Immunol 166:4020-8. 2001
  5. ncbi Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking
    Bonnie J Deroo
    Chromatin and Gene Expression Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 22:4113-23. 2002
  6. ncbi Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
    Delphine Milhas
    INSERM U466, Institut Louis Bugnard, Toulouse, France
    J Biol Chem 280:19836-42. 2005
  7. ncbi Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathways
    Susanta Kar
    Infectious Diseases and Immunology Division, Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Kolkata, India
    Eur J Immunol 39:741-51. 2009
  8. ncbi A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection
    Hulya Karatas
    Department of Neurology, Faculty of Medicine and Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    J Neurosci 29:13761-9. 2009
  9. ncbi The cystatins: protein inhibitors of cysteine proteinases
    V Turk
    Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
    FEBS Lett 285:213-9. 1991
  10. ncbi Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    T W Kim
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Science 277:373-6. 1997

Research Grants

  1. PROTEASE INHIBITORS--NOVEL DRUG THERAPY FOR T GONDII
    Sharon Reed; Fiscal Year: 2001
  2. CYSTATIN C EFFECT ON B16 MELANOMA METASTASIS
    James Cox; Fiscal Year: 2001
  3. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2007
  4. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1991
  5. REGULATION OF CYSTATIN S GENE EXPRESSION
    PHYLLIS SHAW; Fiscal Year: 2002
  6. SALIVARY PROTEINS--MOLECULAR STUDY OF STRUCTURE-FUNCTION
    LIBUSE BOBEK; Fiscal Year: 1993
  7. Water Soluble and Metabolically Stable calpain Inhibitors as Cardioprotectants
    ISAAC DONKOR; Fiscal Year: 2007
  8. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2003
  9. Chemoprevention Potential of Calpain Inhibitors
    ISAAC DONKOR; Fiscal Year: 2007
  10. Clinical & Molecular Studies of Drug Resistant Malaria
    Philip Rosenthal; Fiscal Year: 2007

Detail Information

Publications219 found, 100 shown here

  1. ncbi Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity
    X Guo
    Department of Pharmacology, State University of New York, Buffalo, New York 14214, USA
    J Neurobiol 48:120-30. 2001
    ..These data indicate that BMP-induced dendritic growth requires Smad1 activation and involves proteasome-mediated degradation events...
  2. ncbi Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins
    P van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Mol Biol Cell 12:2556-66. 2001
    ..The data suggest that the ubiquitin-proteasome pathway is involved in an endosomal sorting step of selected membrane proteins to lysosomes, thereby providing a mechanism for regulated degradation...
  3. ncbi Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest
    Xiaotang Hu
    Interdisciplinary Oncology Program, Department of Internal Medicine, University of South Florida, and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 277:16528-37. 2002
    ..Additional support for this conclusion was obtained from experiments showing an increase of proteasome activity in TNF-treated cells and in vitro degradation of cyclin D3 by 26 S proteasome...
  4. ncbi Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response
    L Das
    Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Calcutta, India
    J Immunol 166:4020-8. 2001
    ..These studies provide a promising alternative for protection against leishmaniasis with a switch of CD4(+) differentiation from Th2 to Th1, indicative of long-term resistance...
  5. ncbi Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking
    Bonnie J Deroo
    Chromatin and Gene Expression Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 22:4113-23. 2002
    ..Proteasomes may therefore impact steroid receptor action at multiple levels and exert distinct effects on individual receptor types...
  6. ncbi Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
    Delphine Milhas
    INSERM U466, Institut Louis Bugnard, Toulouse, France
    J Biol Chem 280:19836-42. 2005
    ..Altogether, our data strongly suggest that caspase-10 can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis...
  7. ncbi Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathways
    Susanta Kar
    Infectious Diseases and Immunology Division, Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Kolkata, India
    Eur J Immunol 39:741-51. 2009
    ..Understanding the molecular mechanisms through which cystatin modulates macrophage effector responses will contribute to better define its potential for macrophage-associated diseases, in general...
  8. ncbi A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection
    Hulya Karatas
    Department of Neurology, Faculty of Medicine and Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    J Neurosci 29:13761-9. 2009
    ..Thus, chitosan nanospheres open new and exciting opportunities for brain delivery of biologically active peptides that are useful for the treatment of CNS disorders...
  9. ncbi The cystatins: protein inhibitors of cysteine proteinases
    V Turk
    Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
    FEBS Lett 285:213-9. 1991
    ....
  10. ncbi Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    T W Kim
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Science 277:373-6. 1997
    ....
  11. ncbi Mitochondrial release of caspase-2 and -9 during the apoptotic process
    S A Susin
    Centre National de la Recherche Scientifique, UPR 420, F 94801 Villejuif, France
    J Exp Med 189:381-94. 1999
    ....
  12. ncbi Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    D W Nicholson
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Nature 376:37-43. 1995
    ..A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death...
  13. ncbi Regulation of p53 stability by Mdm2
    M H Kubbutat
    ABL Basic Research Program, NCI FCRDC, Frederick, Maryland 21702 1201, USA
    Nature 387:299-303. 1997
    ..Furthermore, mechanisms regulating the Mdm2-induced degradation of p53 may play a role in controlling the extent and duration of the p53 response...
  14. ncbi Immunomodulatory properties of cystatins
    B Vray
    Laboratoire d Immunologie Expérimentale, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Mol Life Sci 59:1503-12. 2002
    ..On the whole, cystatins and cystatin-like molecules belong to a new category of immunomodulatory molecules. Doubtless increasing data will improve our knowledge of this property, leading to practical applications in immunotherapy...
  15. ncbi Irreversible caspase inhibitors: tools for studying apoptosis
    J C Wu
    Idun Pharmaceuticals, Inc, La Jolla, California 92037, USA
    Methods 17:320-8. 1999
    ..We demonstrate how the resulting quantitative inhibitory constants can be used to identify key caspase activities responsible for apoptosis in specific cellular models...
  16. ncbi Pharmacological rescue of the dystrophin-glycoprotein complex in Duchenne and Becker skeletal muscle explants by proteasome inhibitor treatment
    Stefania Assereto
    Muscular and Neurodegenerative Disease Unit, University of Genoa and G. Gaslini Pediatric Institute, Genoa, Italy
    Am J Physiol Cell Physiol 290:C577-82. 2006
    ..Am J Pathol 163: 1663-1675, 2003). Our present results may have important new implications for the possible pharmacological treatment of Duchenne or Becker muscular dystrophy in humans...
  17. ncbi Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
    B Buendia
    Département de Biologie Supramoléculaire et Cellulaire, Institut Jacques Monod, CNRS, Universite Paris 7, Tour 43, 75251 Paris Cedex 05, France
    J Cell Sci 112:1743-53. 1999
    ....
  18. ncbi Inhibition of the proteasome reduces transfer-induced diabetes in nonobese diabetic mice
    J Petrovic
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden
    Scand J Immunol 60:134-42. 2004
    ..We suggest that MG132 prevents transfer-induced diabetes by directly targeting the autoreactive T cells and lowering their diabetogenic potential...
  19. ncbi Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143-0811, USA
    Proc Natl Acad Sci U S A 101:8721-6. 2004
    ..Our results indicate that although falcipain-1 is expressed by erythrocytic parasites, it is not essential for normal development during this stage or for erythrocyte invasion...
  20. ncbi Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway
    Lora Melman
    Department of Pediatrics, Washington University School of Medicine, CB 8208, St. Louis Children's Hospital, Missouri 63110, USA
    Mol Biol Cell 13:3325-35. 2002
    ..e., LRP, is regulated by the proteasomal system, suggesting a broader function of the proteasome in regulating the trafficking of receptors into the degradation pathway...
  21. ncbi Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis
    Y Maekawa
    Department of Parasitology and Immunology, University of Tokushima School of Medicine, Japan
    J Immunol 161:2120-7. 1998
    ..These findings indicate that cathepsin B inhibitor could switch CD4+ T cell differentiation from Th2 to Th1, suggesting that the alteration in Ag processing modulates the polarity of Th differentiation...
  22. ncbi Purification and catalytic properties of human caspase family members
    M Garcia-Calvo
    Department of Enzymology, Merck Research Laboratories, R80W 250, P O Box 2000, Rahway, New Jersey 07065, USA
    Cell Death Differ 6:362-9. 1999
    ..g. pH, NaCl, Ca2+) on the activities of these enzymes. Some of these variables have a profound effect on the rate of catalysis, a finding that may have important biological implications...
  23. ncbi Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury
    Byung Hee Han
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 277:30128-36. 2002
    ....
  24. ncbi Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages
    S O Kim
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1095-105. 2001
    ....
  25. ncbi Osteoclastogenesis is decreased by cysteine proteinase inhibitors
    Monica Brage
    Department of Oral Cell Biology, , S-90187 Ume, Sweden
    Bone 34:412-24. 2004
    The effects of cystatin C and other cysteine proteinase inhibitors on osteoclast formation and differentiation have been investigated...
  26. ncbi Characterization of proteasome inhibition on astrocytes cell cycle
    Qing Guo Ren
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People s Republic of China
    J Mol Neurosci 38:57-66. 2009
    ....
  27. ncbi Proteasome inhibitor ameliorates severe acute pancreatitis and associated lung injury of rats
    Xi Chen
    Department of General Surgery, The Second Affiliated Hospital of Medical College of Xi an Jiaotong University, Xi an 710004, Shaanxi Province, China
    World J Gastroenterol 14:3249-53. 2008
    ..To observe the effect of proteasome inhibitor MG-132 on severe acute pancreatitis (SAP) and associated lung injury of rats...
  28. ncbi Role of cysteine proteinase inhibitors in preference of Japanese beetles (Popillia japonica) for soybean (Glycine max) leaves of different ages and grown under elevated CO2
    Jorge A Zavala
    Institute for Genomic Biology, University of Illinois, Urbana Champaign, IL, USA
    Oecologia 161:35-41. 2009
    ..hormones jasmonic acid and ethylene; these in turn decrease the gene expression and activity of cysteine proteinase inhibitors (CystPIs), the principal antiherbivore defenses in foliage...
  29. ncbi Modelling and simulating interleukin-10 production and regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes
    Ana Sofia Figueiredo
    Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    FEBS J 276:3454-69. 2009
    ..We also show that p38 affects ERK via secreted IL-10 (autocrine crosstalk). These findings demonstrate how convergent signalling pathways may differentially control kinetic properties of the IL-10 signal...
  30. ncbi Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model
    Thomas M Zollner
    Department of Dermatology, J W Goethe University of Frankfurt, Frankfurt, Germany
    J Clin Invest 109:671-9. 2002
    ..We conclude that inhibition of the proteasome, e.g., by PS-519, is a promising means to treat T cell-mediated disorders such as psoriasis...
  31. ncbi The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH
    Yong Hwan Han
    Department of Physiology, Medical School, Centers for Healthcare Technology Development, Institute for Medical Sciences Chonbuk National University, Jeonju, Korea
    Oncol Rep 22:215-21. 2009
    ..In conclusion, MG132 inhibited the growth of HeLa cells via inducing the cell cycle arrest as well as triggering apoptosis. The changes of ROS and GSH by MG132 were closely related to apoptosis in HeLa cells...
  32. ncbi Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease
    Anthony C Vernon
    Department of Neuroscience, Kings College London, The James Black Centre, UK
    BMC Neurosci 11:1. 2010
    ..Therefore, in this study we have utilised MRI to scan in vivo brains from rodents bearing a nigrostriatal lesion induced by intranigral injection of the proteasome inhibitor lactacystin...
  33. ncbi Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003
    ..In summary, AIF-mediated cell death may be an important mechanism of HI-induced neuronal loss in the immature brain...
  34. ncbi Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi
    J C Engel
    Department of Pathology, University of California, San Francisco, California 94143, USA
    J Cell Sci 111:597-606. 1998
    ..Accumulation of cruzain may decrease mobility of Golgi membranes and result in peripheral distention of cisternae. These major alterations of the Golgi complex parallel the death of T. cruzi epimastigotes...
  35. ncbi A role for the protease falcipain 1 in host cell invasion by the human malaria parasite
    Doron C Greenbaum
    Department of Pharmaceutical Chemistry, Veterans Affairs Medical Center, University of California, San Francisco, CA 94143, USA
    Science 298:2002-6. 2002
    ..These results demonstrate a specific role for falcipain 1 in host cell invasion and establish a potential new target for antimalarial therapeutics...
  36. ncbi Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
    M Yokouchi
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 274:31707-12. 1999
    ..This mechanism participates in the down-regulation of tyrosine kinase receptors and loss of this function, as occurs in the naturally occurring 70Z-Cbl isoform, probably contributes to oncogenic transformation...
  37. ncbi Cysteine protease inhibitors as chemotherapy for parasitic infections
    J H McKerrow
    Department of Pathology, VA Medical Center, University of California, San Francisco 94121, USA
    Bioorg Med Chem 7:639-44. 1999
    ..This suggests that cysteine protease inhibitors may provide an alternative to traditional therapy in drug-resistant organisms...
  38. ncbi Importance of FADD signaling in serum deprivation- and hypoxia-induced cardiomyocyte apoptosis
    Wei Chao
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:31639-45. 2002
    ..These data suggest a primary role for FADD/caspase-8 signaling that is necessary and sufficient for apoptosis of CMs subjected to hypoxia/SD...
  39. ncbi Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile
    Marcia Alvarez-Fernandez
    Department of Clinical Chemistry, Institute of Laboratory Medicine, Lund University, SE 221 85 Lund, Sweden
    J Biol Chem 280:18221-8. 2005
    ....
  40. ncbi Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum
    Erica L Dahl
    Department of Medicine, San Francisco General Hospital, University of California, Box 0811, San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 139:205-12. 2005
    ..Our results support overlapping but not fully redundant roles for falcipain-2 and -3, which are targeted to the food vacuole and activated sequentially to degrade hemoglobin in erythrocytic parasites...
  41. ncbi Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions
    R Navab
    Department of Surgery, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec H3A 1A4, Canada
    J Biol Chem 276:13644-9. 2001
    ..inhibition of endosomal IGF-I-degrading enzymes in human breast and murine lung carcinoma cells by the cysteine proteinase inhibitors, E-64 and CA074-methyl ester, profoundly altered receptor trafficking and signaling...
  42. ncbi Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis
    Inmaculada Segura
    Department of Immunology and Oncology, , , Campus de Cantoblanco, E-28049 Madrid, Spain
    FASEB J 16:833-41. 2002
    ..This evidence indicates that endothelial cell apoptosis may be relevant for precise vascular tissue rearrangement in in vitro and in vivo angiogenesis...
  43. ncbi Improved trypanocidal activities of cathepsin L inhibitors
    Njinkeng Joseph Nkemgu
    Abteilung Parasitologie, , Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Int J Antimicrob Agents 22:155-9. 2003
    ..b. brucei. Compared with general cysteine proteinase inhibitors used previously by ourselves and others, the present inhibitors had improved selectivity indices and, ..
  44. ncbi Identification of cysteine protease inhibitors that belong to cystatin family 1 in the cellular slime mold Dictyostelium discoideum
    Medhat S El-Halawany
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Biol Chem 385:547-50. 2004
    ..Using specific polyclonal antibodies, we found that cystatin A1 is stably expressed throughout the life cycle of Dictyostelium, whereas cystatin A2 expression is up-regulated during the course of development...
  45. ncbi Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
    A C Monteiro
    , Bloco G, CCS, Universidade Federal do Rio de Janeiro, , Rio de Janeiro, CEP 21990-400, Brazil
    J Cell Sci 114:3933-42. 2001
    ..The intersection of chagasin and cruzipain trafficking pathways may represent a checkpoint for downstream regulation of proteolysis in trypanosomatid protozoa...
  46. ncbi Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex
    H Blanchard
    Biochemisches Institut, Universitat Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    J Mol Biol 302:9-16. 2000
    ..We propose that the subsite S(3) must be considered as an important specificity-determining factor...
  47. ncbi The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
    Alida Coppi
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
    J Exp Med 201:27-33. 2005
    ..Inhibitors of CSP processing inhibit cell invasion in vitro, and treatment of mice with E-64, a highly specific cysteine protease inhibitor, completely inhibits sporozoite infectivity in vivo...
  48. ncbi Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response
    T Dainichi
    Department of Parasitology and Immunology, The University of Tokushima School of Medicine, Tokushima, Japan
    Infect Immun 69:7380-6. 2001
    ..brasiliensis. Based on these findings, N. brasiliensis appears to skillfully evade host immune systems by secreting nippocystatin, which modulates antigen processing in antigen-presenting cells of hosts...
  49. ncbi Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1177-86. 2000
    ..These experiments show that cathepsin F, in a subset of antigen presenting cells (APCs), can efficiently degrade Ii. Different APCs can thus use distinct proteases to mediate MHC class II maturation and peptide loading...
  50. ncbi Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis
    E O Harrington
    Pulmonary/Critical Care Medicine Section, Providence Veterans Affairs Medical Center, and Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02908, USA
    Am J Physiol Lung Cell Mol Physiol 280:L342-53. 2001
    ..These studies demonstrate that disruption of focal adhesion contacts is an early, but not an irrevocable, event in endothelial cell apoptosis...
  51. ncbi Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?
    Shunyi Zhu
    Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Trends Microbiol 16:353-60. 2008
    ....
  52. ncbi Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
    P J Rosenthal
    Department of Medicine, San Francisco General Hospital, University of California 94143, USA
    Antimicrob Agents Chemother 40:1600-3. 1996
    We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase...
  53. ncbi Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 150:96-106. 2006
    ..Our data suggest key roles for falcipain-2 and falcipain-3 in the development of erythrocytic malaria parasites and a complex interplay between P. falciparum cysteine and aspartic proteases...
  54. ncbi Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity
    S J Martin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 271:28753-6. 1996
    ....
  55. ncbi Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
    T M Caserta
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    Apoptosis 8:345-52. 2003
    ..Our data indicate that the specificity, effectiveness, and reduced toxicity of caspase inhibitors can be significantly enhanced using carboxyterminal o-phenoxy groups and may have important uses in vivo...
  56. ncbi Parkin is recruited to the centrosome in response to inhibition of proteasomes
    Jinghui Zhao
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Cell Sci 116:4011-9. 2003
    ..This process may provide a subcellular locale for parkin to ubiquitinate and degrade protein aggregates critically involved in the pathogenesis of Parkinson's disease...
  57. ncbi Activation of caspase-2 in apoptosis
    H Li
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts 02129 and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:21010-7. 1997
    ....
  58. ncbi Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843-4466, USA
    Cancer Lett 236:198-212. 2006
    ....
  59. ncbi Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells
    Anke Klose
    Department of Dermatology, University of Cologne, Germany
    Anal Biochem 353:57-62. 2006
    ....
  60. ncbi Viral cystatin evolution and three-dimensional structure modelling: a case of directional selection acting on a viral protein involved in a host-parasitoid interaction
    Céline Serbielle
    Institut de Recherche sur la Biologie de l Insecte, UMR CNRS 6035, Faculte des Sciences et Techniques, Parc de Grandmont, 37200 Tours, France
    BMC Biol 6:38. 2008
    ..To understand the constraints imposed by this particular system on virus evolution, we studied a polydnavirus gene family encoding cyteine protease inhibitors of the cystatin superfamily...
  61. ncbi Cleavage of focal adhesion kinase by caspases during apoptosis
    L P Wen
    Department of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 272:26056-61. 1997
    ..Our results suggest that disruption of FAK may contribute to the morphological changes observed in apoptotic suspension and adherent cells...
  62. ncbi Bax directly induces release of cytochrome c from isolated mitochondria
    J M Jurgensmeier
    Program on Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:4997-5002. 1998
    ....
  63. ncbi Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development
    Mohamed Benderdour
    Department of Nutrition, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 278:45154-9. 2003
    ..Indeed, they emphasize the implication of post-translational modifications of mitochondrial metabolic enzymes by 4-hydroxynonenal in the early oxidative stress-related pathophysiological events linked to cardiac hypertrophy development...
  64. ncbi Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade
    France Vaillancourt
    Orthopaedic Research Laboratory, Sacre Coeur Hospital, University of Montreal, Montreal, Quebec, Canada
    J Cell Biochem 100:1217-31. 2007
    ..Taken together, these findings illustrate the central role played by HNE in the regulation of COX-2 and iNOS in OA. The aldehyde induced selectively COX-2 expression via ATF/CRE activation and inhibited iNOS via IKKalpha inactivation...
  65. ncbi p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells
    H Garrett R Thompson
    Department of Biomedical Engineering, University of California, CA 92697 2715, USA
    Oncogene 22:2322-33. 2003
    ....
  66. ncbi Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
    Lei Chen
    Department of Pharmacology and Toxicology, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA
    Mol Pharmacol 64:334-45. 2003
    ....
  67. ncbi Interferon-gamma induces apoptosis of lens alphaTN4-1 cells and proteasome inhibition has an antiapoptotic effect
    Niranjan Awasthi
    Department of Biochemistry, University of Medicine and Dentistry-New Jersey Medical School, Newark, New Jersey 07101-1709, USA
    Invest Ophthalmol Vis Sci 45:222-9. 2004
    ..It also inhibits the STP-induced increase in caspase-3 activity. If IFN-gamma-induced apoptosis of lens epithelial cells contributes to cataractogenesis, the proteasome may be a therapeutic target...
  68. ncbi Divergence of apoptosis-inducing and preventing signals in bacteria-faced macrophages through myeloid differentiation factor 88 and IL-1 receptor-associated kinase members
    Klaus Ruckdeschel
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Munich, Germany
    J Immunol 168:4601-11. 2002
    ....
  69. ncbi Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways
    Christian Bogner
    IIIrd Department of Medicine, Technical University of Munich, Munich, Germany
    Exp Hematol 31:218-25. 2003
    ..CONCLUSION: Proteasome inhibition is highly effective in proliferating B-CLL cells and induces apoptosis using a caspase-dependent and -independent pathway...
  70. ncbi The 3C protease activity of enterovirus 71 induces human neural cell apoptosis
    Mei-Ling Li
    School of Medical Technology, Chang Gung University, Tao-Yuan, Taiwan
    Virology 293:386-95. 2002
    ....
  71. ncbi Role of ATP in influenza virus budding
    E K Hui
    Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, Los Angeles, California 90095-1747, USA
    Virology 290:329-41. 2001
    ..Data presented in the report indicate that influenza virus budding is an active ATP-dependent process and suggest that reduced virus budding by ATP depletion and DMSO treatment may be partly due to decreased membrane viscosity...
  72. ncbi BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells
    Tetsuya Kurosu
    Department of Hematology and Oncology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8519, Japan
    Oncogene 22:4459-68. 2003
    ..These results raise the possibility that deregulated expression of BCL6 may endow lymphoma cells with resistance to chemotherapeutic reagents, most likely by enhancing the antioxidant defense systems...
  73. ncbi Ubiquitin-proteasome pathway as a new target for the prevention of restenosis
    Silke Meiners
    Medizinische Klinik und Poliklinik, Charit, Campus Mitte, , Germany
    Circulation 105:483-9. 2002
    ..Our data suggest the ubiquitin-proteasome system as a new target in the prevention of vascular restenosis...
  74. ncbi Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
    Ann-Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017, USA
    Proc Natl Acad Sci U S A 100:9946-51. 2003
    ..Identification of compounds that target the activity of IRE1 alpha/XBP-1 may yield novel therapies for the treatment of multiple myeloma and other malignancies that rely on an intact UPR...
  75. ncbi Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes
    Philippe Holzmuller
    , , 34032 Montpellier Cedex 1, France
    Infect Immun 70:3727-35. 2002
    ..The determination of biochemical pathways leading up to cell death might ultimately allow the identification of new therapeutic targets...
  76. ncbi Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells
    Ann H Cory
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Anticancer Res 22:3805-9. 2002
    ....
  77. ncbi Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3
    Aurélia E Lewis
    Department of Medicine, Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Exp Cell Res 289:1-10. 2003
    ..By contrast, the cysteine protease inhibitor, E-64d, blocked apoptosis. Cysteine proteases not of the caspase family may either act more closely to the apoptotic process than caspases or lie on an alternative, more active pathway...
  78. ncbi Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D
    Hyun A Kim
    Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea
    J Rheumatol 30:550-8. 2003
    ..MG132 and actinomycin D show different characteristics in terms of apoptosis signaling...
  79. ncbi Preferential induction of apoptosis for primary human leukemic stem cells
    Monica L Guzman
    Blood and Marrow Transplant Program, Markey Cancer Center, Division of HematologyOncology, University of Kentucky Medical Center, Lexington, KY 40536-0093 USA
    Proc Natl Acad Sci U S A 99:16220-5. 2002
    ..Further, the data begin to elucidate the molecular mechanisms that underlie LSC-specific apoptosis and suggest new directions for AML therapy...
  80. ncbi Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells
    Jong-M Kim
    Department of Anatomy and Cell Biology, Dong-A University College of Medicine, 3-1 Dongdaesin-Dong, Seo-gu, Busan, South Korea 602-714
    J Pharmacol Exp Ther 305:474-81. 2003
    ..Lactacystin-induced apoptosis in RPE-J cells is closely associated with an early mitochondrial hyperpolarization induced by intracellular alkalinization...
  81. ncbi Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates
    Kenneth J Rodgers
    Cell Biology Unit, The Heart Research Institute, 145 Missenden Road, Camperdown, NSW 2050, Sydney, Australia
    Int J Biochem Cell Biol 35:716-27. 2003
    ..tissue preparations which could not be inhibited by the proteasome inhibitor epoxomycin but was inhibitable by two cysteine proteinase inhibitors and by lactacystin suggesting that lactacystin may not be completely proteasome specific.
  82. ncbi Proteasomal dysfunction induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation: a mechanism contributing to neurodegeneration?
    Dong Hoon Hyun
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College, London, UK
    J Neurochem 83:360-70. 2002
    ..We propose that the proteasomal system is a significant target of HNE neurotoxicity in a wide range of neurodegenerative diseases, especially if abnormal proteins are being expressed...
  83. ncbi Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol
    Jiyan Ma
    Howard Hughes Medical Institute, Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Science 298:1781-5. 2002
    ....
  84. ncbi Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors
    H C A Drexler
    Max Planck Institute for Physiological and Clinical Research, Department of Molecular Cell Biology, Bad Nauheim, Germany
    Cell Death Differ 10:290-301. 2003
    ..The expression levels of p27(Kip1) thus constitute an important parameter, which decides on the overall sensitivity of cells against the cytotoxic effect of proteasome inhibitors...
  85. ncbi Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells
    Pamela L Rice
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Cancer Ther 2:885-92. 2003
    ....
  86. ncbi The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/Abl-positive cell lines sensitive and resistant to imatinib mesylate
    Simona Gatto
    Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
    Haematologica 88:853-63. 2003
    ..The use of PS-341 should be explored in patients with chronic myelogenous leukemia resistant to IM. Trials of combinations of PS-341 and IM require cautious design...
  87. ncbi Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    Deepak Nijhawan
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Genes Dev 17:1475-86. 2003
    ..The disappearance of Mcl-1 is also required for other mitochondrial apoptotic events including Bax translocation, cytochrome c release, and caspase activation...
  88. ncbi Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity
    Akira Shimizu
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 123:459-65. 2003
    ..Caspases and calpains are regarded to be important factors in the regulation of cell death in the inner ear. We hypothesized that caspase or calpain inhibitors would protect hair cells from aminoglycoside ototoxicity...
  89. ncbi Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes
    Yoshikazu Emi
    Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Park City, Hyogo 678 1297, Japan
    Arch Biochem Biophys 405:163-9. 2002
    ....
  90. ncbi c-Jun N-terminal kinase pathway mediates Lactacystin-induced cell death in a neuronal differentiated Neuro2a cell line
    Chen Sang
    Department of Neurology, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Aichi, Japan
    Brain Res Mol Brain Res 108:7-17. 2002
    ..Our results shed light on the association among the proteasomal dysfunction, JNK pathway and neuronal cell death, leading to the elucidation of its possible role in the pathogenesis of neurodegenerative diseases...
  91. ncbi Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition
    Y Huang
    Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA
    Biochem Biophys Res Commun 283:762-9. 2001
    ..Overexpression of caspase-3s in 293 cells is more resistant to apoptosis induced by proteasome inhibition. Furthermore, we identified that proteasome inhibition stabilized the level of caspase-3s...
  92. ncbi Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis
    Elaine Hau Jin Yew
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
    J Neurochem 94:943-56. 2005
    ....
  93. ncbi The proteasome regulates receptor-mediated endocytosis of interleukin-2
    A Yu
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 276:381-5. 2001
    ..Therefore, a functional proteasome is required for optimal endocytosis of the IL-2R/ligand complex and is essential for the subsequent lysosomal degradation of IL-2, possibly by regulating trafficking to the lysosome...
  94. ncbi Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway
    Isabelle Lang-Rollin
    Department of Neurology, Columbia University, New York, USA
    J Neurochem 90:1511-20. 2004
    ..We conclude that proteasomal inhibition of mouse sympathetic neurons activates the intrinsic apoptotic pathway involving bcl-2 family members and the mitochondria...
  95. ncbi Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis
    Alessio Nencioni
    Massachusetts Institute of Technology, Department of Biology, Center for Cancer Research, Cambridge, MA, USA
    Blood 105:3255-62. 2005
    ..Pharmacologic or genetic approaches targeting Mcl-1, including therapeutic RNAi, may increase the effectiveness of these compounds...
  96. ncbi The docking protein HEF1 is an apoptotic mediator at focal adhesion sites
    S F Law
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 20:5184-95. 2000
    ..Based on these results, we propose that dysregulation of HEF1 and its family members along with FAK may signal the destruction of focal adhesion sites and regulate the onset of apoptosis...
  97. ncbi Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes
    Olaf Goldbaum
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 53:891-901. 2006
    ..Hence, individual cells respond differently to proteasomal inhibition and the therapeutic use of proteasomal inhibitors, e.g. for the treatment of cancer or inflammatory diseases, needs to be carefully evaluated...
  98. ncbi Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cells
    Wending Yang
    Children's Memorial Research Center, The Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 2430 N. Halsted Street, Chicago, IL 60614, USA
    Cancer Lett 243:217-27. 2006
    ..Taken together, our results demonstrated that proteasome inhibition elicits activation of multiple signaling pathways in prostate cancer cells...
  99. ncbi Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells
    Katalin Nagy
    First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Anticancer Res 25:3321-6. 2005
    ..The results indicate that combination treatment with these novel anti-tumor agents in leukemia requires careful evaluation of their molecular interaction at the level of apoptosis induction...
  100. ncbi Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis
    R C Armstrong
    Idun Pharmaceuticals, Inc, La Jolla, California 92037, USA
    J Neurosci 17:553-62. 1997
    ..The lack of CPP32 activation during granule neuron necrosis suggests that proteolytic processing and activation of CED3/ICE proteases are specific biochemical markers of apoptosis...
  101. ncbi Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B
    E A Atkinson
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 273:21261-6. 1998
    ....

Research Grants117 found, 100 shown here

  1. PROTEASE INHIBITORS--NOVEL DRUG THERAPY FOR T GONDII
    Sharon Reed; Fiscal Year: 2001
    ..of cystine proteinases and their role in peptide degradation and evaluating the effect of specific cysteine proteinase inhibitors on parasite survival and identify their site of action...
  2. CYSTATIN C EFFECT ON B16 MELANOMA METASTASIS
    James Cox; Fiscal Year: 2001
    ..The overall goal of this project is to elucidate steps by which natural cysteine proteinase inhibitors, the cystatins, may act as antimetastatic agents...
  3. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2007
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  4. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1991
    ..long term objective is to determine the role(s) of the cysteine proteinase cathepsin B and endogenous cysteine proteinase inhibitors (CPI) in tumor cell metastasis...
  5. REGULATION OF CYSTATIN S GENE EXPRESSION
    PHYLLIS SHAW; Fiscal Year: 2002
    ..Cystatins are evolutionarily conserved, naturally occurring cysteine proteinase inhibitors that regulate proteolysis by endogenous cysteine proteinases, as well as by proteinases of microbial ..
  6. SALIVARY PROTEINS--MOLECULAR STUDY OF STRUCTURE-FUNCTION
    LIBUSE BOBEK; Fiscal Year: 1993
    ..Molecules that we will concentrate on are cystatins (cysteine proteinase inhibitors and anti-bacterial/viral agents) and histatins (anti-fungal, particularly anti-candidal and anti-..
  7. Water Soluble and Metabolically Stable calpain Inhibitors as Cardioprotectants
    ISAAC DONKOR; Fiscal Year: 2007
    ..Furthermore, the proposed studies will provide mechanistic insight into the mode of action of calpain inhibitors as cardioprotectants. ..
  8. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2003
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  9. Chemoprevention Potential of Calpain Inhibitors
    ISAAC DONKOR; Fiscal Year: 2007
    ..The proposal is significant and innovative because it seeks to investigate calpain as a pharmacological target for the discovery of a new class of chemoprevention agents. ..
  10. Clinical & Molecular Studies of Drug Resistant Malaria
    Philip Rosenthal; Fiscal Year: 2007
    ..We anticipate that the experiments designed to achieve these aims will contribute to improved management of malaria and to a better understanding of the genetic factors that impact upon responses to therapy for this disease. ..
  11. High Throughput Assay for Screening Compounds(RMI)
    James McKerrow; Fiscal Year: 2005
    ..Computational and informatics capability is in place to acquire, store and cross-reference this data, and provide access to the scientific community through an open-source website. ..
  12. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2006
    ..abstract_text> ..
  13. Biliary Atresia clinical Research Consortium
    Philip Rosenthal; Fiscal Year: 2007
    ..abstract_text> ..
  14. Targeting Calpain for Novel Anticancer Agents
    ISAAC DONKOR; Fiscal Year: 2005
    ..Additionally, the compounds are useful biomedical tools for investigating the intracellular roles of Calpain due to their metabolic stability. The compounds are also potential anticancer agents. ..
  15. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2007
    ..abstract_text> ..
  16. PROBING THE S' SUBSITES OF CALPAIN
    ISAAC DONKOR; Fiscal Year: 2002
    ..Selected potent and cell permeable inhibitors will be tested in the rat isolated heart ischemia model for cardioprotective effect. ..
  17. Falcipain Cysteine Proteases of Malaria Parasites
    Philip Rosenthal; Fiscal Year: 2005
    ..Experiments designed to accomplish these aims should improve our understanding of the biology of malaria parasites and aid in the characterization of falcipains as potential drug targets. ..
  18. Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    Philip Jon Rosenthal; Fiscal Year: 2010
    ....
  19. Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    James H McKerrow; Fiscal Year: 2010
    ....
  20. Proteasome Inhibition and ER Stress
    David McConkey; Fiscal Year: 2009
    ....
  21. 25-hydroxy-D3 as a possible chemopreventive agent for breast cancer
    Xinjian Peng; Fiscal Year: 2007
    ....
  22. AMP-activated kinase in diabetic complications
    Ming Hui Zou; Fiscal Year: 2007
    ..They should also yield insights into how endothelium attempts to protect itself against these stresses and whether AMPK is a potential target for therapy for diabetes. ..
  23. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2007
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  24. Oxidant stress and diabetic endothelial dysfunction
    Ming Hui Zou; Fiscal Year: 2009
    ..abstract_text> ..
  25. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  26. THE THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2007
    ....
  27. Divalent Metal Transporter: Role in Manganese Toxicity
    JEROME ROTH; Fiscal Year: 2004
    ....
  28. Anti-Leukemic Activity of the Novel Triterpeniod CDDO
    Michael Andreeff; Fiscal Year: 2004
    ..The long-term goal of our proposed mechanistic and efficacy studies is to determine the potential of CDDO as a novel anti-leukemia and anti-tumor agent. ..
  29. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2010
    ..In this proposal, we will explore the potential to utilize GSK3B inhibitors to improve surgical outcomes for patients with metastatic MTC. ..
  30. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2006
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  31. MECHANISMS OF TRANSFORMATION OF HEMOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 1993
    ....
  32. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  33. GLUTATHIONE TRANSFERASES AND OXIDATIVE STRESS TOXICOLOGY
    Piotr Zimniak; Fiscal Year: 2000
    ....
  34. MECHANISMS OF TRANSFORMATION OF HEMATOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 2001
    ..An understanding of how these signal transduction and apoptotic pathways impinge upon one another will further our comprehension of the consequences of abnormal oncogene activation and tumor progression. ..
  35. Ras/Raf & PI3K/Akt Induced Breast Cancer Drug Resistance
    JAMES MC CUBREY; Fiscal Year: 2003
    ..Through these studies, more information will be available to treat breast and other cancer patients with combinations of drugs, which inhibit signal transduction and anti-apoptotic pathways leading to drug resistance. ..