cysteine proteinase inhibitors

Summary

Summary: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.

Top Publications

  1. pmc Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins
    P van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Mol Biol Cell 12:2556-66. 2001
  2. ncbi The cystatins: protein inhibitors of cysteine proteinases
    V Turk
    Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
    FEBS Lett 285:213-9. 1991
  3. pmc Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
    J C Engel
    Department of Pathology, University of California San Francisco, California 94143, USA
    J Exp Med 188:725-34. 1998
  4. ncbi Functions of propeptide parts in cysteine proteases
    Bernd Wiederanders
    Institute of Biochemistry, Klinikum, Friedrich Schiller University Jena, Nonnenplan 2, D 07743 Jena, Germany
    Curr Protein Pept Sci 4:309-26. 2003
  5. ncbi Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold tolerance
    Xinxin Zhang
    Asian Natural Environment Science Center, The University of Tokyo, Midori Cho 1 1 1, Nishitokyo City, Tokyo, Japan
    Plant Mol Biol 68:131-43. 2008
  6. ncbi Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 150:96-106. 2006
  7. ncbi The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation
    Dima El-Sukkari
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Melbourne, Australia
    J Immunol 171:5003-11. 2003
  8. pmc Protective mechanisms by cystatin C in neurodegenerative diseases
    Sebastien Gauthier
    Nathan S Kline Institute, Orangeburg, NY 10962, USA
    Front Biosci (Schol Ed) 3:541-54. 2011
  9. ncbi Cystatins up-regulate nitric oxide release from interferon-gamma-activated mouse peritoneal macrophages
    L Verdot
    Laboratoire d Enzymologie et de Chimie des Protéines, Universite Francois Rabelais, F37032 Tours, France
    J Biol Chem 271:28077-81. 1996
  10. pmc Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell death
    Igor Jurak
    Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 82:4812-22. 2008

Research Grants

Detail Information

Publications267 found, 100 shown here

  1. pmc Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins
    P van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Mol Biol Cell 12:2556-66. 2001
    ..The data suggest that the ubiquitin-proteasome pathway is involved in an endosomal sorting step of selected membrane proteins to lysosomes, thereby providing a mechanism for regulated degradation...
  2. ncbi The cystatins: protein inhibitors of cysteine proteinases
    V Turk
    Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
    FEBS Lett 285:213-9. 1991
    ....
  3. pmc Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
    J C Engel
    Department of Pathology, University of California San Francisco, California 94143, USA
    J Exp Med 188:725-34. 1998
    ..No abnormalities were noted in the Golgi complex of host cells. This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a parasitic infection...
  4. ncbi Functions of propeptide parts in cysteine proteases
    Bernd Wiederanders
    Institute of Biochemistry, Klinikum, Friedrich Schiller University Jena, Nonnenplan 2, D 07743 Jena, Germany
    Curr Protein Pept Sci 4:309-26. 2003
    ..The function of propeptides of two other important classes of cysteine peptidases - the calpains, clan CA family C4, and the caspases, clan CD family C 14 - are not considered in this review...
  5. ncbi Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold tolerance
    Xinxin Zhang
    Asian Natural Environment Science Center, The University of Tokyo, Midori Cho 1 1 1, Nishitokyo City, Tokyo, Japan
    Plant Mol Biol 68:131-43. 2008
    Two cysteine proteinase inhibitors (cystatins) from Arabidopsis thaliana, designated AtCYSa and AtCYSb, were characterized. Recombinant GST-AtCYSa and GST-AtCYSb were expressed in Escherichia coli and purified...
  6. ncbi Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 150:96-106. 2006
    ..Our data suggest key roles for falcipain-2 and falcipain-3 in the development of erythrocytic malaria parasites and a complex interplay between P. falciparum cysteine and aspartic proteases...
  7. ncbi The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation
    Dima El-Sukkari
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Melbourne, Australia
    J Immunol 171:5003-11. 2003
    ..Our results also show that CyC expression can differ markedly between closely related cell types, suggesting the existence of hitherto unrecognized mechanisms of control of CyC expression...
  8. pmc Protective mechanisms by cystatin C in neurodegenerative diseases
    Sebastien Gauthier
    Nathan S Kline Institute, Orangeburg, NY 10962, USA
    Front Biosci (Schol Ed) 3:541-54. 2011
    ..These data suggest that CysC is a therapeutic candidate that can potentially prevent brain damage and neurodegeneration...
  9. ncbi Cystatins up-regulate nitric oxide release from interferon-gamma-activated mouse peritoneal macrophages
    L Verdot
    Laboratoire d Enzymologie et de Chimie des Protéines, Universite Francois Rabelais, F37032 Tours, France
    J Biol Chem 271:28077-81. 1996
    ..demonstrate that members of all 3 cystatin families share another common property unrelated to their function of cysteine proteinase inhibitors, i.e. up-regulation of NO production, which biological significance remains to be elucidated.
  10. pmc Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell death
    Igor Jurak
    Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 82:4812-22. 2008
    ..Moreover, the fact that MCMV-infected cells are protected from both Bak- and Bax-mediated cell death suggests that MCMV possesses an additional, as-yet-unidentified mechanism to block Bak-mediated apoptosis...
  11. ncbi Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)
    J Kos
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, 1000 Ljubljana, Slovenia
    Oncol Rep 5:1349-61. 1998
    ..Their application for diagnosis, follow-up and the anticancer therapy has also been proposed...
  12. ncbi Proteinaceous cysteine protease inhibitors
    G Dubin
    Faculty of Biotechnology, Jagiellonian University, ul Gronostajowa 7, 30 387, Krakow, Poland
    Cell Mol Life Sci 62:653-69. 2005
    ..The work primarily highlights biological processes in which the inhibitors are involved and focuses on pathologies resulting from aberrant protease-inhibitor balance, pointing out emerging possibilities for their correction...
  13. ncbi Multifunctional role of plant cysteine proteinases
    Małgorzata Grudkowska
    Plant Physiology and Biochemistry Department, Plant Breeding and Acclimatization Institute, Radzikow, Warsaw, Poland
    Acta Biochim Pol 51:609-24. 2004
    ..In this review an attempt was undertaken to illustrate these multiple roles of cysteine proteinases and the mechanisms underlying their action...
  14. pmc Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
    D A Matthews
    Agouron Pharmaceuticals, Inc, 3565 General Atomics Court, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:11000-7. 1999
    ..Recently, one compound in this series, AG7088, has entered clinical trials...
  15. ncbi Caspase inhibitors
    P G Ekert
    The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Death Differ 6:1081-6. 1999
    ....
  16. ncbi Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation
    D S Campbell
    Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, United Kingdom
    Neuron 32:1013-26. 2001
    ..These results suggest that guidance molecules steer axon growth by triggering rapid local changes in protein levels in growth cones...
  17. ncbi Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003
    ..In summary, AIF-mediated cell death may be an important mechanism of HI-induced neuronal loss in the immature brain...
  18. ncbi Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosis
    H Fauvel
    , Lille Cedex, 59045, France
    Am J Physiol Heart Circ Physiol 280:H1608-14. 2001
    ..Caspase inhibition strategy may represent a therapeutic approach to endotoxin-induced myocardial dysfunction...
  19. ncbi Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding
    G D Lin
    Center for Macromolecular Crystallography, University of Alabama at Birmingham 35294, USA
    Nat Struct Biol 4:539-47. 1997
    ..The crystal structure of a Ca2+ bound domain VI-inhibitor (PD150606) complex has been refined to 2.1 A resolution. A possible mode for calpain inhibition is discussed...
  20. ncbi Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
    ..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
  21. ncbi Bombyx cysteine proteinase inhibitor (BCPI) homologous to propeptide regions of cysteine proteinases is a strong, selective inhibitor of cathepsin L-like cysteine proteinases
    M Kurata
    Laboratory of Biochemistry and Radiation Biology, Department of Veterinary Sciences, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan
    J Biochem 130:857-63. 2001
    ..Recombinant BCPI lacking the two C-terminal amino acid residues still retained substantial inhibitory activity. Our results indicate that BCPI is a stable and highly selective inhibitor of cathepsin L-like cysteine proteinases...
  22. doi Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi
    Diego S Buarque
    Department of Biochemistry, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, 04044 020 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 413:241-7. 2011
    ..cruzi. Together, these results indicate that Tigutcystatin may be involved in modulation of T. cruzi in intestinal tract by inhibiting parasite cysteine proteases, which represent the virulence factors of this protozoan...
  23. pmc Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d
    S Eksi
    Department of Biology, Loyola University Chicago, 6525 N Sheridan Rd, Chicago, IL 60626, USA
    Antimicrob Agents Chemother 51:1064-70. 2007
    ..The ability of a membrane-permeant cysteine protease inhibitor to significantly reduce malaria parasite transmission suggests that future drug design should include evaluation of gametogenesis and sporogonic development...
  24. pmc Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L
    T Bevec
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    J Exp Med 183:1331-8. 1996
    ..The Ii inhibitory fragment shows no sequence homology with the known cysteine protease inhibitors, and may, therefore, represent a new class...
  25. ncbi Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury
    Susan M Knoblach
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 24:1119-32. 2004
    ..These data suggest that neuroprotection by z-DEVD-fmk may, in part, reflect inhibition of calpain-related necrotic cell death...
  26. ncbi Expression, purification, and inhibitory activities of mouse cytotoxic T-lymphocyte antigen-2alpha
    Mitsuhiro Kurata
    Laboratory of Biochemistry and Radiation Biology, Department of Veterinary Sciences, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Protein Expr Purif 32:119-25. 2003
    ..Our results indicate that mouse CTLA-2alpha is a selective inhibitor of the cathepsin L-like cysteine proteinases...
  27. pmc Characterization of the entire cystatin gene family in barley and their target cathepsin L-like cysteine-proteases, partners in the hordein mobilization during seed germination
    Manuel Martinez
    Centro de Biotecnología y Genómica de Plantas, Universidad Politecnica de Madrid, Campus Montegancedo Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcon, Madrid, Spain
    Plant Physiol 151:1531-45. 2009
    ..The opposite pattern of transcription expression in gibberellin-treated aleurones presented by inhibitors and enzymes allowed proteases to specifically degrade B, C, and D hordeins stored in the endosperm of barley seeds...
  28. doi Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
    Kristina Berggren
    Department of Chemistry, Medicinal Chemistry, University of Gothenburg, Goteborg, Sweden
    Bioorg Med Chem 17:3463-70. 2009
    ..Eight compounds were identified as inhibitors of IdeS in an in vitro assay. The most potent compounds contained an aldehyde function, thus acting as efficient reversible inhibitors, nitrile and azide derivatives showed moderate activity...
  29. doi Cruzain : the path from target validation to the clinic
    Mohammed Sajid
    Afd Parasitologie, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 712:100-15. 2011
    ....
  30. ncbi Peptidomimetic inhibitors of cathepsin K
    W Cameron Black
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Que, Canada
    Curr Top Med Chem 10:745-51. 2010
    ..Three of these compounds have progressed into clinical trials and one, odanacatib (5), is currently in Phase III studies for the treatment of post-menopausal osteoporosis...
  31. ncbi Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland
    D P Dickinson
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1124, USA
    DNA Cell Biol 21:47-65. 2002
    ....
  32. ncbi Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
    Delphine Milhas
    INSERM U466, Institut Louis Bugnard, Toulouse, France
    J Biol Chem 280:19836-42. 2005
    ..Altogether, our data strongly suggest that caspase-10 can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis...
  33. ncbi Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response
    L Das
    Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Calcutta, India
    J Immunol 166:4020-8. 2001
    ..These studies provide a promising alternative for protection against leishmaniasis with a switch of CD4(+) differentiation from Th2 to Th1, indicative of long-term resistance...
  34. doi Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathways
    Susanta Kar
    Infectious Diseases and Immunology Division, Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Kolkata, India
    Eur J Immunol 39:741-51. 2009
    ..Understanding the molecular mechanisms through which cystatin modulates macrophage effector responses will contribute to better define its potential for macrophage-associated diseases, in general...
  35. pmc Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking
    Bonnie J Deroo
    Chromatin and Gene Expression Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 22:4113-23. 2002
    ..Proteasomes may therefore impact steroid receptor action at multiple levels and exert distinct effects on individual receptor types...
  36. ncbi A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection
    Hulya Karatas
    Department of Neurology, Faculty of Medicine and Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    J Neurosci 29:13761-9. 2009
    ..Thus, chitosan nanospheres open new and exciting opportunities for brain delivery of biologically active peptides that are useful for the treatment of CNS disorders...
  37. pmc Bax directly induces release of cytochrome c from isolated mitochondria
    J M Jurgensmeier
    Program on Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:4997-5002. 1998
    ....
  38. ncbi Cystatin C
    David J Newman
    South West Thames Institute for Renal Research, St Helier Hospital, Carshalton, Surrey, UK
    Ann Clin Biochem 39:89-104. 2002
    ....
  39. ncbi Cowpea bruchid Callosobruchus maculatus uses a three-component strategy to overcome a plant defensive cysteine protease inhibitor
    K Zhu-Salzman
    Department of Entomology, Texas A and M University, College Station, TX 77843, USA
    Insect Mol Biol 12:135-45. 2003
    ..Our results suggest that the cowpea bruchid adapts to the challenge of scN by qualitative and quantitative remodelling of its digestive protease complement, and by activating scN-degrading protease activity...
  40. ncbi Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose?
    D P Dickinson
    Medical College of Georgia, School of Dentistry, Department of Oral Biology and Maxillofacial Pathology, 1120 15th Street, Augusta, GA 30912, USA
    Crit Rev Oral Biol Med 13:485-508. 2002
    ....
  41. ncbi A novel inhibitor protein for Bombyx cysteine proteinase is homologous to propeptide regions of cysteine proteinases
    Y Yamamoto
    Department of Biochemistry and Radiation Biology, College of Agriculture, Yamaguchi University, Japan
    FEBS Lett 448:257-60. 1999
    ..The results suggest that some cysteine proteinase proregions may have evolved as autonomous modules and become inhibitor proteins for cysteine proteinases...
  42. doi The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K
    Jacques Yves Gauthier
    Merck Frosst Centre for Therapeutic Research, 16711 Transcanada Hwy, Kirkland, Que, Canada
    Bioorg Med Chem Lett 18:923-8. 2008
    ..Evaluation in dermal fibroblast culture showed minimal intracellular collagen accumulation relative to less selective Cat K inhibitors...
  43. ncbi Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    T W Kim
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Science 277:373-6. 1997
    ....
  44. pmc Mitochondrial release of caspase-2 and -9 during the apoptotic process
    S A Susin
    Centre National de la Recherche Scientifique, UPR 420, F 94801 Villejuif, France
    J Exp Med 189:381-94. 1999
    ....
  45. ncbi The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH
    Yong Hwan Han
    Department of Physiology, Medical School, Centers for Healthcare Technology Development, Institute for Medical Sciences Chonbuk National University, Jeonju, Korea
    Oncol Rep 22:215-21. 2009
    ..In conclusion, MG132 inhibited the growth of HeLa cells via inducing the cell cycle arrest as well as triggering apoptosis. The changes of ROS and GSH by MG132 were closely related to apoptosis in HeLa cells...
  46. pmc Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model
    Samuel G Melendez-Lopez
    Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
    Eukaryot Cell 6:1130-6. 2007
    ..role of secreted cysteine proteinases in amebic invasion, we tested the effect of the vinyl sulfone cysteine proteinase inhibitors K11777 and WRR483 on invasion of human colonic xenografts...
  47. ncbi Role of cysteine proteinase inhibitors in preference of Japanese beetles (Popillia japonica) for soybean (Glycine max) leaves of different ages and grown under elevated CO2
    Jorge A Zavala
    Institute for Genomic Biology, University of Illinois, Urbana Champaign, IL, USA
    Oecologia 161:35-41. 2009
    ..hormones jasmonic acid and ethylene; these in turn decrease the gene expression and activity of cysteine proteinase inhibitors (CystPIs), the principal antiherbivore defenses in foliage...
  48. doi Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia
    Xiaoping Li
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
    Cardiovasc Res 83:72-9. 2009
    ..The present study was to investigate the roles of calpain/calpastatin system in cardiomyocyte caspase-3 activation, TNF-alpha expression, and myocardial dysfunction during LPS stimulation...
  49. pmc Characterization of Solanum tuberosum multicystatin and its structural comparison with other cystatins
    Mark S Nissen
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
    Plant Cell 21:861-75. 2009
    ..The unique molecular properties of the oligomeric PMC crystal are discussed in relation to its potential function in regulating the activity of proteases in potato tubers...
  50. ncbi Regulation of p53 stability by Mdm2
    M H Kubbutat
    ABL Basic Research Program, NCI FCRDC, Frederick, Maryland 21702 1201, USA
    Nature 387:299-303. 1997
    ..Furthermore, mechanisms regulating the Mdm2-induced degradation of p53 may play a role in controlling the extent and duration of the p53 response...
  51. ncbi Immunomodulatory properties of cystatins
    B Vray
    Laboratoire d Immunologie Expérimentale, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Mol Life Sci 59:1503-12. 2002
    ..On the whole, cystatins and cystatin-like molecules belong to a new category of immunomodulatory molecules. Doubtless increasing data will improve our knowledge of this property, leading to practical applications in immunotherapy...
  52. ncbi Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    D W Nicholson
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Nature 376:37-43. 1995
    ..A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death...
  53. pmc Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes
    Dusan Kordis
    Department of Biochemistry and Molecular and Structural Biology, J, Stefan Institute, Ljubljana, Slovenia
    BMC Evol Biol 9:266. 2009
    ..Our aim has been to obtain a comprehensive insight into their origin, distribution, diversity, evolution and classification in Eukaryota, Bacteria and Archaea...
  54. ncbi Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis
    J Kos
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, Ljubljana, Slovenia
    Clin Cancer Res 6:505-11. 2000
    The levels of cysteine proteinase inhibitors stefin A, stefin B, and cystatin C were determined using ELISAs in sera obtained preoperatively from 345 patients with colorectal cancer and in control sera from 125 healthy blood donors...
  55. ncbi Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung
    Mizuki Ikehara
    Department of Thoracic Oncology, Kanagawa Cancer Center, Asahi ku, Yokohama 241 0815, Japan
    Oncol Rep 9:835-8. 2002
    ..014; Wilcoxon test, p=0.021). It can be concluded that the expression of survivin in tumor cells is a factor of poor prognosis in patients with small adenocarcinoma of the lung...
  56. ncbi Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsiveness
    S Sugawara
    Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai, Japan
    J Immunol 165:411-8. 2000
    ..These results suggest that gingipains preferentially cleave monocyte CD14, resulting in attenuation of the cellular recognition of bacteria, and as a consequence sustain chronic inflammation...
  57. ncbi A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor
    Bice Todd
    Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Biol 328:131-46. 2003
    ..0A and 2.3A resolution, respectively. In addition, we built a homology model for the complex between domain IV and DIA19 peptide of calpastatin. Finally, we present a model for the calpastatin-inhibited calpain...
  58. ncbi The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitors
    M J North
    Department of Biological and Molecular Sciences, School of Natural Sciences, University of Stirling, U K
    Mol Biochem Parasitol 39:183-93. 1990
    ..vaginalis and T. foetus. The information on the specificities will be useful for assessing the features required in proteinase inhibitors if they are to be of potential value as antitrichomonal agents...
  59. pmc Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of the head and neck: relation to prognosis
    P Strojan
    Department of Radiotherapy, Institute of Oncology, SI 1000 Ljubljana, Slovenia
    Br J Cancer 90:1961-8. 2004
    ..C levels and improved survival concurs with the concept of the protective role of high levels of cysteine proteinase inhibitors in tissue homogenates that has been previously suggested by the survival results in breast and lung ..
  60. ncbi Orally bioavailable cathepsin K inhibitors with pyrrolopyrimidine scaffold
    Naoki Teno
    Novartis Institutes for BioMedical Research, Tsukuba, Ibaraki, Japan
    Curr Top Med Chem 10:752-66. 2010
    ..This article constitutes a near comprehensive review of the published scientific literature on small molecule non-peptidic inhibitors for cathepsin K developed by Novartis...
  61. ncbi Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis
    E O Harrington
    Pulmonary/Critical Care Medicine Section, Providence Veterans Affairs Medical Center, and Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02908, USA
    Am J Physiol Lung Cell Mol Physiol 280:L342-53. 2001
    ..These studies demonstrate that disruption of focal adhesion contacts is an early, but not an irrevocable, event in endothelial cell apoptosis...
  62. ncbi Falcipain inhibition as a promising antimalarial target
    Maria Marco
    GlaxoSmithKline, Diseases of the Developing World, Madrid, Spain
    Curr Top Med Chem 12:408-44. 2012
    ..Some important aspects to focus on future development of falcipain inhibition are also discussed...
  63. ncbi Cathepsins B and L are markers for clinically invasive types of meningiomas
    T Strojnik
    Department of Neurosurgery, Maribor Teaching Hospital, Ljubljanska, Slovenia
    Neurosurgery 48:598-605. 2001
    ..The aim of this study was to evaluate cathepsins B and L and their inhibitors as new prognostic factors that could distinguish malignant from benign forms of meningiomas...
  64. pmc The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis
    J Delic
    Laboratoire de Recherche Correspondant No2 du CEA DSV DRR, Fontenay Aux Roses Institut Curie, Paris, France
    Br J Cancer 77:1103-7. 1998
    ....
  65. ncbi The function of propeptide domains of cysteine proteinases
    B Wiederanders
    , Klinikum,
    Adv Exp Med Biol 477:261-70. 2000
    ..The experiments showed a 10-25 fold faster renaturation rate in presence than in absence of the propeptide underlining its function as intramolecular chaperone...
  66. ncbi IAP proteins: blocking the road to death's door
    Guy S Salvesen
    Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 3:401-10. 2002
    ..Here, we review the functional and structural properties of this fascinating group of proteins, and of several recently identified IAP-binding factors that regulate IAP function...
  67. ncbi Cysteine proteinase inhibitors in elapid and hydrophiid snake venoms
    Hiroshi Mashiko
    Department of Hygienic Chemistry, Meiji Pharmaceutical University, Kiyose, 2 522 1, Noshio, Tokyo 204 8588, Japan
    Toxicon 40:1275-81. 2002
    ..These venoms contained 12.0-13.0 kDa low molecular-weight cysteine proteinase inhibitors.
  68. ncbi Multitrophic interactions involving genetically modified potatoes, nontarget aphids, natural enemies and hyperparasitoids
    S E Cowgill
    Centre for Plant Sciences, School of Biology, University of Leeds, LS2 9JT, UK
    Mol Ecol 13:639-47. 2004
    ..The results indicate that transgenic nematode resistance is potentially more compatible with aphid biological control than is current nematicide use...
  69. ncbi C1A cysteine-proteases and their inhibitors in plants
    Manuel Martinez
    Centro de Biotecnología y Genómica de Plantas UPM INIA, Campus Montegancedo, Universidad Politecnica de Madrid, 28223 Pozuelo de Alarcon, Madrid, Spain
    Physiol Plant 145:85-94. 2012
    ..Further in vivo interactions were demonstrated by bimolecular fluorescent complementation, suggesting their participation in the same physiological processes...
  70. ncbi Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions
    R Navab
    Department of Surgery, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec H3A 1A4, Canada
    J Biol Chem 276:13644-9. 2001
    ..inhibition of endosomal IGF-I-degrading enzymes in human breast and murine lung carcinoma cells by the cysteine proteinase inhibitors, E-64 and CA074-methyl ester, profoundly altered receptor trafficking and signaling...
  71. ncbi Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
    F A Norris
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:10987-9. 1997
    ..These data suggest that the calpain-mediated inhibition of 4-phosphatase is involved in the phosphatidylinositol 3, 4-bisphosphate accumulation in thrombin-stimulated platelets...
  72. pmc MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity
    Wu Yang
    Cytovia, Inc a subsidiary of Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, CA 92121, U S A
    Br J Pharmacol 140:402-12. 2003
    ..It has the ability to protect cells from a variety of apoptotic insults, and is systemically active in three animal models of apoptosis, including brain ischemia...
  73. ncbi CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation
    A Takahashi
    Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, The King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, United Kingdom
    J Biol Chem 271:32487-90. 1996
    ..These results reveal that CrmA/SPI-2 can inhibit a caspase responsible both for lamin A cleavage and for the nuclear disintegration characteristic of apoptosis...
  74. ncbi Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages
    S O Kim
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1095-105. 2001
    ....
  75. ncbi Osteoclastogenesis is decreased by cysteine proteinase inhibitors
    Monica Brage
    Department of Oral Cell Biology, Umea University, S 90187 Umea, Sweden
    Bone 34:412-24. 2004
    The effects of cystatin C and other cysteine proteinase inhibitors on osteoclast formation and differentiation have been investigated...
  76. pmc Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease
    Anthony C Vernon
    Department of Neuroscience, Kings College London, The James Black Centre, UK
    BMC Neurosci 11:1. 2010
    ..Therefore, in this study we have utilised MRI to scan in vivo brains from rodents bearing a nigrostriatal lesion induced by intranigral injection of the proteasome inhibitor lactacystin...
  77. pmc Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model
    Thomas M Zollner
    Department of Dermatology, J W Goethe University of Frankfurt, Frankfurt, Germany
    J Clin Invest 109:671-9. 2002
    ..We conclude that inhibition of the proteasome, e.g., by PS-519, is a promising means to treat T cell-mediated disorders such as psoriasis...
  78. ncbi Modelling and simulating interleukin-10 production and regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes
    Ana Sofia Figueiredo
    Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    FEBS J 276:3454-69. 2009
    ..We also show that p38 affects ERK via secreted IL-10 (autocrine crosstalk). These findings demonstrate how convergent signalling pathways may differentially control kinetic properties of the IL-10 signal...
  79. ncbi Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury
    Byung Hee Han
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 277:30128-36. 2002
    ....
  80. pmc Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway
    Lora Melman
    Department of Pediatrics, Washington University School of Medicine, CB 8208, St Louis Children s Hospital, Missouri 63110, USA
    Mol Biol Cell 13:3325-35. 2002
    ..e., LRP, is regulated by the proteasomal system, suggesting a broader function of the proteasome in regulating the trafficking of receptors into the degradation pathway...
  81. pmc Proteasome inhibitor ameliorates severe acute pancreatitis and associated lung injury of rats
    Xi Chen
    Department of General Surgery, The Second Affiliated Hospital of Medical College of Xi an Jiaotong University, Xi an 710004, Shaanxi Province, China
    World J Gastroenterol 14:3249-53. 2008
    ..To observe the effect of proteasome inhibitor MG-132 on severe acute pancreatitis (SAP) and associated lung injury of rats...
  82. doi Characterization of proteasome inhibition on astrocytes cell cycle
    Qing Guo Ren
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People s Republic of China
    J Mol Neurosci 38:57-66. 2009
    ....
  83. ncbi Inhibition of the proteasome reduces transfer-induced diabetes in nonobese diabetic mice
    J Petrovic
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Scand J Immunol 60:134-42. 2004
    ..We suggest that MG132 prevents transfer-induced diabetes by directly targeting the autoreactive T cells and lowering their diabetogenic potential...
  84. ncbi Pharmacological rescue of the dystrophin-glycoprotein complex in Duchenne and Becker skeletal muscle explants by proteasome inhibitor treatment
    Stefania Assereto
    Muscular and Neurodegenerative Disease Unit, University of Genoa and G Gaslini Pediatric Institute, Genoa, Italy
    Am J Physiol Cell Physiol 290:C577-82. 2006
    ..Am J Pathol 163: 1663-1675, 2003). Our present results may have important new implications for the possible pharmacological treatment of Duchenne or Becker muscular dystrophy in humans...
  85. pmc Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143 0811, USA
    Proc Natl Acad Sci U S A 101:8721-6. 2004
    ..Our results indicate that although falcipain-1 is expressed by erythrocytic parasites, it is not essential for normal development during this stage or for erythrocyte invasion...
  86. ncbi Purification and catalytic properties of human caspase family members
    M Garcia-Calvo
    Department of Enzymology, Merck Research Laboratories, R80W 250, P O Box 2000, Rahway, New Jersey 07065, USA
    Cell Death Differ 6:362-9. 1999
    ..g. pH, NaCl, Ca2+) on the activities of these enzymes. Some of these variables have a profound effect on the rate of catalysis, a finding that may have important biological implications...
  87. ncbi Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis
    Y Maekawa
    Department of Parasitology and Immunology, University of Tokushima School of Medicine, Japan
    J Immunol 161:2120-7. 1998
    ..These findings indicate that cathepsin B inhibitor could switch CD4+ T cell differentiation from Th2 to Th1, suggesting that the alteration in Ag processing modulates the polarity of Th differentiation...
  88. ncbi Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
    B Buendia
    Département de Biologie Supramoléculaire et Cellulaire, Institut Jacques Monod, CNRS, Universite Paris 7, Tour 43, 75251 Paris Cedex 05, France
    J Cell Sci 112:1743-53. 1999
    ....
  89. ncbi Irreversible caspase inhibitors: tools for studying apoptosis
    J C Wu
    Idun Pharmaceuticals, Inc, La Jolla, California 92037, USA
    Methods 17:320-8. 1999
    ..We demonstrate how the resulting quantitative inhibitory constants can be used to identify key caspase activities responsible for apoptosis in specific cellular models...
  90. ncbi Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
    M Yokouchi
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 274:31707-12. 1999
    ..This mechanism participates in the down-regulation of tyrosine kinase receptors and loss of this function, as occurs in the naturally occurring 70Z-Cbl isoform, probably contributes to oncogenic transformation...
  91. ncbi A role for the protease falcipain 1 in host cell invasion by the human malaria parasite
    Doron C Greenbaum
    Department of Pharmaceutical Chemistry, Veterans Affairs Medical Center, University of California, San Francisco, CA 94143, USA
    Science 298:2002-6. 2002
    ..These results demonstrate a specific role for falcipain 1 in host cell invasion and establish a potential new target for antimalarial therapeutics...
  92. ncbi Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi
    J C Engel
    Department of Pathology, University of California, San Francisco, California 94143, USA
    J Cell Sci 111:597-606. 1998
    ..Accumulation of cruzain may decrease mobility of Golgi membranes and result in peripheral distention of cisternae. These major alterations of the Golgi complex parallel the death of T. cruzi epimastigotes...
  93. ncbi Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development
    Mohamed Benderdour
    Department of Nutrition, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 278:45154-9. 2003
    ..Indeed, they emphasize the implication of post-translational modifications of mitochondrial metabolic enzymes by 4-hydroxynonenal in the early oxidative stress-related pathophysiological events linked to cardiac hypertrophy development...
  94. ncbi Activation of caspase-2 in apoptosis
    H Li
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts 02129 and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:21010-7. 1997
    ....
  95. ncbi Cleavage of focal adhesion kinase by caspases during apoptosis
    L P Wen
    Department of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 272:26056-61. 1997
    ..Our results suggest that disruption of FAK may contribute to the morphological changes observed in apoptotic suspension and adherent cells...
  96. ncbi Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade
    France Vaillancourt
    Orthopaedic Research Laboratory, Sacre Coeur Hospital, University of Montreal, Montreal, Quebec, Canada
    J Cell Biochem 100:1217-31. 2007
    ..Taken together, these findings illustrate the central role played by HNE in the regulation of COX-2 and iNOS in OA. The aldehyde induced selectively COX-2 expression via ATF/CRE activation and inhibited iNOS via IKKalpha inactivation...
  97. pmc The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
    Alida Coppi
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
    J Exp Med 201:27-33. 2005
    ..Inhibitors of CSP processing inhibit cell invasion in vitro, and treatment of mice with E-64, a highly specific cysteine protease inhibitor, completely inhibits sporozoite infectivity in vivo...
  98. ncbi Identification of cysteine protease inhibitors that belong to cystatin family 1 in the cellular slime mold Dictyostelium discoideum
    Medhat S El-Halawany
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Biol Chem 385:547-50. 2004
    ..Using specific polyclonal antibodies, we found that cystatin A1 is stably expressed throughout the life cycle of Dictyostelium, whereas cystatin A2 expression is up-regulated during the course of development...
  99. ncbi Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis
    Inmaculada Segura
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Campus de Cantoblanco, E 28049 Madrid, Spain
    FASEB J 16:833-41. 2002
    ..This evidence indicates that endothelial cell apoptosis may be relevant for precise vascular tissue rearrangement in in vitro and in vivo angiogenesis...
  100. pmc Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1177-86. 2000
    ..These experiments show that cathepsin F, in a subset of antigen presenting cells (APCs), can efficiently degrade Ii. Different APCs can thus use distinct proteases to mediate MHC class II maturation and peptide loading...
  101. ncbi Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells
    Anke Klose
    Department of Dermatology, University of Cologne, Germany
    Anal Biochem 353:57-62. 2006
    ....

Research Grants117 found, 100 shown here

  1. PROTEASE INHIBITORS--NOVEL DRUG THERAPY FOR T GONDII
    Sharon Reed; Fiscal Year: 2001
    ..of cystine proteinases and their role in peptide degradation and evaluating the effect of specific cysteine proteinase inhibitors on parasite survival and identify their site of action...
  2. CYSTATIN C EFFECT ON B16 MELANOMA METASTASIS
    James Cox; Fiscal Year: 2001
    ..The overall goal of this project is to elucidate steps by which natural cysteine proteinase inhibitors, the cystatins, may act as antimetastatic agents...
  3. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2007
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  4. DESIGN AND SYNTHESIS OF CYSTEINE PROTEINASE INHIBITORS
    DANIEL RICH; Fiscal Year: 1990
    ..Develop a 3- dimensional model for the human cysteine proteinases, cathepsin B, H, and L, for which X-ray crystal structures are not available...
  5. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1990
    ..long term objective is to determine the role(s) of the cysteine proteinase cathepsin B and endogenous cysteine proteinase inhibitors (CPI) in tumor cell metastasis...
  6. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1991
    ..long term objective is to determine the role(s) of the cysteine proteinase cathepsin B and endogenous cysteine proteinase inhibitors (CPI) in tumor cell metastasis...
  7. REGULATION OF CYSTATIN S GENE EXPRESSION
    PHYLLIS SHAW; Fiscal Year: 1999
    ..Cystatins are evolutionarily conserved, naturally occurring cysteine proteinase inhibitors that regulate proteolysis by endogenous cysteine proteinases, as well as by proteinases of microbial ..
  8. REGULATION OF CYSTATIN S GENE EXPRESSION
    PHYLLIS SHAW; Fiscal Year: 2000
    ..Cystatins are evolutionarily conserved, naturally occurring cysteine proteinase inhibitors that regulate proteolysis by endogenous cysteine proteinases, as well as by proteinases of microbial ..
  9. REGULATION OF CYSTATIN S GENE EXPRESSION
    PHYLLIS SHAW; Fiscal Year: 2002
    ..Cystatins are evolutionarily conserved, naturally occurring cysteine proteinase inhibitors that regulate proteolysis by endogenous cysteine proteinases, as well as by proteinases of microbial ..
  10. REGULATION OF CYSTATIN S GENE EXPRESSION
    PHYLLIS SHAW; Fiscal Year: 2001
    ..Cystatins are evolutionarily conserved, naturally occurring cysteine proteinase inhibitors that regulate proteolysis by endogenous cysteine proteinases, as well as by proteinases of microbial ..
  11. REGULATION OF INDUCIBLE RAT SALIVARY CYSTATIN
    Gurrinder Bedi; Fiscal Year: 1990
    b>Cysteine proteinase inhibitors of the cystatin superfamily are grouped into three families on the basis of their molecular structure...
  12. PROTEASE INHIBITORS IN HUMAN BLADDER CANCER INVASION
    Brian Liu; Fiscal Year: 1993
    ..In this proposal, we will determine the effects of cysteine proteinase inhibitors in inhibiting the activity of plasma membrane bound cathepsin B at a biochemical level using enzyme ..
  13. PROTEASE INHIBITORS IN HUMAN BLADDER CANCER INVASION
    Brian Liu; Fiscal Year: 1991
    ..In this proposal, we will determine the effects of cysteine proteinase inhibitors in inhibiting the activity of plasma membrane bound cathepsin B at a biochemical level using enzyme ..
  14. MOLECULAR ANALYSIS OF HUMAN SALIVARY CYSTATIN GENES
    Douglas Dickinson; Fiscal Year: 1990
    ..The type 2 cystatins are a group of cysteine proteinase inhibitors that are major protein constituents of saliva...
  15. CHARACTERIZATION OF TUMOR CYSTEINE INHIBITORS
    Bonnie Sloane; Fiscal Year: 1990
    ..is to determine the role(s) of cysteine proteinases (in particular cathepsin B) and endogenous low Mr cysteine proteinase inhibitors (CPI) in tumor cell metastasis. Increases activities of several cysteine proteinases, e.g...
  16. ORGANIZATION AND EXPRESSION OF CYSTATIN GENES
    Gurrinder Bedi; Fiscal Year: 1992
    ..Cystatins are cysteine proteinase inhibitors that are thought to be involved in the protective mechanisms against endogenous cysteine proteinases ..
  17. SALIVARY PROTEINS--MOLECULAR STUDY OF STRUCTURE-FUNCTION
    LIBUSE BOBEK; Fiscal Year: 1992
    ..Molecules that we will concentrate on are cystatins (cysteine proteinase inhibitors and anti-bacterial/viral agents) and histatins (anti-fungal, particularly anti-candidal and anti-..
  18. SALIVARY PROTEINS--MOLECULAR STUDY OF STRUCTURE-FUNCTION
    LIBUSE BOBEK; Fiscal Year: 1993
    ..Molecules that we will concentrate on are cystatins (cysteine proteinase inhibitors and anti-bacterial/viral agents) and histatins (anti-fungal, particularly anti-candidal and anti-..
  19. CYSTATIN C EFFECT ON B16 MELANOMA METASTASIS
    James Cox; Fiscal Year: 2000
    ..The overall goal of this project is to elucidate steps by which natural cysteine proteinase inhibitors, the cystatins, may act as antimetastatic agents...
  20. CYSTATIN C EFFECT ON B16 MELANOMA METASTASIS
    James Cox; Fiscal Year: 1999
    ..The overall goal of this project is to elucidate steps by which natural cysteine proteinase inhibitors, the cystatins, may act as antimetastatic agents...
  21. PROTEASE INHIBITORS--NOVEL DRUG THERAPY FOR T GONDII
    Sharon Reed; Fiscal Year: 2000
    ..of cystine proteinases and their role in peptide degradation and evaluating the effect of specific cysteine proteinase inhibitors on parasite survival and identify their site of action...
  22. PROTEASE INHIBITORS--NOVEL DRUG THERAPY FOR T GONDII
    Sharon Reed; Fiscal Year: 1999
    ..of cystine proteinases and their role in peptide degradation and evaluating the effect of specific cysteine proteinase inhibitors on parasite survival and identify their site of action...
  23. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2008
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  24. Water Soluble and Metabolically Stable calpain Inhibitors as Cardioprotectants
    ISAAC DONKOR; Fiscal Year: 2007
    ..Furthermore, the proposed studies will provide mechanistic insight into the mode of action of calpain inhibitors as cardioprotectants. ..
  25. Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    James McKerrow; Fiscal Year: 2008
    ..No Abstract Provided. ..
  26. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2004
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  27. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2003
    ..abstract_text> ..
  28. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2003
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  29. Water-Soluble and Metabolically Stable Calpain Inhibitors as Cardioprotectants
    ISAAC DONKOR; Fiscal Year: 2008
    ..Furthermore, the proposed studies will provide mechanistic insight into the mode of action of calpain inhibitors as cardioprotectants. ..
  30. Chemoprevention Potential of Calpain Inhibitors
    ISAAC DONKOR; Fiscal Year: 2007
    ..The proposal is significant and innovative because it seeks to investigate calpain as a pharmacological target for the discovery of a new class of chemoprevention agents. [unreadable] [unreadable] [unreadable]..
  31. Clinical & Molecular Studies of Drug Resistant Malaria
    Philip Rosenthal; Fiscal Year: 2008
    ..abstract_text> ..
  32. Clinical & Molecular Studies of Drug Resistant Malaria
    Philip Rosenthal; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  33. High Throughput Assay for Screening Compounds(RMI)
    James McKerrow; Fiscal Year: 2005
    ..Computational and informatics capability is in place to acquire, store and cross-reference this data, and provide access to the scientific community through an open-source website. ..
  34. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2006
    ..abstract_text> ..
  35. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2006
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  36. Biliary Atresia clinical Research Consortium
    Philip Rosenthal; Fiscal Year: 2007
    ..abstract_text> ..
  37. Targeting Calpain for Novel Anticancer Agents
    ISAAC DONKOR; Fiscal Year: 2005
    ..Additionally, the compounds are useful biomedical tools for investigating the intracellular roles of Calpain due to their metabolic stability. The compounds are also potential anticancer agents. ..
  38. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2005
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  39. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2007
    ..abstract_text> ..
  40. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 1999
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  41. Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    Philip Rosenthal; Fiscal Year: 2008
    ..abstract_text> ..
  42. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2000
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  43. PROBING THE S' SUBSITES OF CALPAIN
    ISAAC DONKOR; Fiscal Year: 2002
    ..Selected potent and cell permeable inhibitors will be tested in the rat isolated heart ischemia model for cardioprotective effect. ..
  44. Falcipain Cysteine Proteases of Malaria Parasites
    Philip Rosenthal; Fiscal Year: 2005
    ..Experiments designed to accomplish these aims should improve our understanding of the biology of malaria parasites and aid in the characterization of falcipains as potential drug targets. ..
  45. Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    Philip Rosenthal; Fiscal Year: 2009
    ....
  46. Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    Philip Jon Rosenthal; Fiscal Year: 2010
    ....
  47. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2002
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  48. Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    James H McKerrow; Fiscal Year: 2010
    ....
  49. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2001
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  50. SCREENS TO IDENTIFY GAIN OF FUNCTION AH RECEPTOR MUTANTS INVOLVED IN DEGRADATION
    RICHARD POLLENZ; Fiscal Year: 2008
    ..e. steroid hormone receptors). [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  51. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2004
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  52. Proteasome Inhibition and ER Stress
    David McConkey; Fiscal Year: 2009
    ....
  53. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2009
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  54. Reactive Nitrogen and Accelerated Atherosclerosis in Type I Diabetes
    Ming Hui Zou; Fiscal Year: 2009
    ..These studies will provide novel information as to how the metabolic stresses associated with diabetes cause damage to the endothelium. ..
  55. 25-hydroxy-D3 as a possible chemopreventive agent for breast cancer
    Xinjian Peng; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. AMP-activated kinase in diabetic complications
    Ming Hui Zou; Fiscal Year: 2007
    ..They should also yield insights into how endothelium attempts to protect itself against these stresses and whether AMPK is a potential target for therapy for diabetes. ..
  57. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Melanie Mediavilla Varela; Fiscal Year: 2008
    ..These studies will provide insights into the mechanisms underlying prostate tumor resistance to cell death and lead to development of novel therapeutic strategies for PCa. [unreadable] [unreadable] [unreadable]..
  58. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2007
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  59. MAPK/PKR Modulation of Diaphragm Weakness
    GERALD SUPINSKI; Fiscal Year: 2009
    ..We will both characterize the effects of inflammation on DISC formation, localization, and autocatalytic activity and determine if these alterations can be blocked by inhibition of p38, JNK, and/or PKR signaling pathways. ..
  60. Oxidant stress and diabetic endothelial dysfunction
    Ming Hui Zou; Fiscal Year: 2009
    ..abstract_text> ..
  61. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  62. THE THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2008
    ....
  63. Reactive Nitrogen and Accelerated Atherosclerosis in Type I Diabetes
    Ming Hui Zou; Fiscal Year: 2008
    ..These studies will provide novel information as to how the metabolic stresses associated with diabetes cause damage to the endothelium. ..
  64. Surgery Summer Research Experience for Medical Students
    Herbert Chen; Fiscal Year: 2008
    ..abstract_text> ..
  65. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2008
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  66. THE THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2007
    ....
  67. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2006
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  68. Reactive nitrogen species & accelerated atherosclerosis
    Ming Hui Zou; Fiscal Year: 2006
    ....
  69. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2004
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  70. Anti-Leukemic Activity of the Novel Triterpeniod CDDO
    Michael Andreeff; Fiscal Year: 2003
    ..The long-term goal of our proposed mechanistic and efficacy studies is to determine the potential of CDDO as a novel anti-leukemia and anti-tumor agent. ..
  71. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  72. Divalent Metal Transporter: Role in Manganese Toxicity
    JEROME ROTH; Fiscal Year: 2004
    ....
  73. Anti-Leukemic Activity of the Novel Triterpeniod CDDO
    Michael Andreeff; Fiscal Year: 2002
    ..The long-term goal of our proposed mechanistic and efficacy studies is to determine the potential of CDDO as a novel anti-leukemia and anti-tumor agent. ..
  74. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2000
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  75. Anti-Leukemic Activity of the Novel Triterpeniod CDDO
    Michael Andreeff; Fiscal Year: 2004
    ..The long-term goal of our proposed mechanistic and efficacy studies is to determine the potential of CDDO as a novel anti-leukemia and anti-tumor agent. ..
  76. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2010
    ..In this proposal, we will explore the potential to utilize GSK3B inhibitors to improve surgical outcomes for patients with metastatic MTC. ..
  77. Reactive nitrogen species & accelerated atherosclerosis
    Ming Hui Zou; Fiscal Year: 2005
    ....
  78. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2006
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  79. MECHANISMS OF TRANSFORMATION OF HEMOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 1993
    ....
  80. AMPK as a redox sensor and modulator
    Ming Hui Zou; Fiscal Year: 2008
    ..Completion of the proposed studies will provide novel insights into whether AMPK is a potential target for therapy in smoking and common diseases including aging, obesity, diabetes, hypertension, and atherosclerosis. ..
  81. Role of glutathione transferases in life span extension of C. elegans
    Piotr Zimniak; Fiscal Year: 2009
    ..The type of damage to be studied here could become the target of future interventions designed to slow aging and deter age-associated diseases. ..
  82. MECHANISMS OF TRANSFORMATION OF HEMOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 1992
    ....
  83. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  84. GLUTATHIONE TRANSFERASES AND OXIDATIVE STRESS TOXICOLOGY
    Piotr Zimniak; Fiscal Year: 2000
    ....
  85. MECHANISMS OF TRANSFORMATION OF HEMATOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 2001
    ..An understanding of how these signal transduction and apoptotic pathways impinge upon one another will further our comprehension of the consequences of abnormal oncogene activation and tumor progression. ..
  86. Ras/Raf & PI3K/Akt Induced Breast Cancer Drug Resistance
    JAMES MC CUBREY; Fiscal Year: 2003
    ..Through these studies, more information will be available to treat breast and other cancer patients with combinations of drugs, which inhibit signal transduction and anti-apoptotic pathways leading to drug resistance. ..