nucleic acid synthesis inhibitors

Summary

Summary: Compounds that inhibit cell production of DNA or RNA.

Top Publications

  1. pmc Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits
    Marcelo V Netto
    The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 22:562-74. 2006
  2. ncbi Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA
    Xushan Wang
    Cardiovascular Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 280:19298-305. 2005
  3. pmc Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition
    Yaron Shav-Tal
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Mol Biol Cell 16:2395-413. 2005
  4. pmc Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest
    Xiaoyan Lu
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:35325-37. 2009
  5. ncbi The DNA replication checkpoint response stabilizes stalled replication forks
    M Lopes
    Istituto F.I.R.C. di Oncologia Molecolare, Via Serio 21, 20141, Milano, Italy
    Nature 412:557-61. 2001
  6. ncbi NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II
    M Barboric
    Howard Hughes Medical Institute Departments of Medicine, Microbiology, and Immunology University of California at San Francisco 94143, USA
    Mol Cell 8:327-37. 2001
  7. pmc Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
    Timothy P Spann
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Biol 156:603-8. 2002
  8. pmc Topoisomerase II can unlink replicating DNA by precatenane removal
    I Lucas
    , , 46 rue d'Ulm, F-75230 Paris Cedex 05, France
    EMBO J 20:6509-19. 2001
  9. ncbi Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
    J M Park
    National Creative Research Initiative Center for Genome Regulation, Department of Biochemistry, Yonsei University, 120 749, Seoul, South Korea
    Mol Cell 8:9-19. 2001
  10. pmc BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
    Alan R Schoenfeld
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1130, New York, NY 10029, USA
    Mol Cell Biol 24:7444-55. 2004

Research Grants

Detail Information

Publications185 found, 100 shown here

  1. pmc Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits
    Marcelo V Netto
    The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 22:562-74. 2006
    ..To determine the mechanism through which topical mitomycin C prevents and treats corneal haze after photorefractive keratectomy (PRK) and to examine the effects of dosage and duration of exposure...
  2. ncbi Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA
    Xushan Wang
    Cardiovascular Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 280:19298-305. 2005
    ....
  3. pmc Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition
    Yaron Shav-Tal
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Mol Biol Cell 16:2395-413. 2005
    ....
  4. pmc Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest
    Xiaoyan Lu
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:35325-37. 2009
    ..These results indicate that in addition to its well studied role in promoting cell cycle progression, cyclin E also has a role in regulating cell cycle arrest in response to DNA damage...
  5. ncbi The DNA replication checkpoint response stabilizes stalled replication forks
    M Lopes
    Istituto F.I.R.C. di Oncologia Molecolare, Via Serio 21, 20141, Milano, Italy
    Nature 412:557-61. 2001
    ..Further, Rad53 is required to properly maintain stable replication forks during the block. We propose that Rad53 prevents collapse of the fork when replication pauses...
  6. ncbi NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II
    M Barboric
    Howard Hughes Medical Institute Departments of Medicine, Microbiology, and Immunology University of California at San Francisco 94143, USA
    Mol Cell 8:327-37. 2001
    ..Remarkably, DRB inhibition sensitized cells to TNF-alpha-induced apoptosis. Thus, NF-kappaB requires P-TEFb to stimulate the elongation of transcription and P-TEFb plays an unexpected role in regulating apoptosis...
  7. pmc Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
    Timothy P Spann
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Biol 156:603-8. 2002
    ..Furthermore, immunofluorescence observations indicate that this selective inhibition of polymerase II-dependent transcription involves the TATA binding protein, a component of the basal transcription factor TFIID...
  8. pmc Topoisomerase II can unlink replicating DNA by precatenane removal
    I Lucas
    , , 46 rue d'Ulm, F-75230 Paris Cedex 05, France
    EMBO J 20:6509-19. 2001
    ..We discuss the role of chromatin structure in driving DNA unlinking during S phase...
  9. ncbi Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
    J M Park
    National Creative Research Initiative Center for Genome Regulation, Department of Biochemistry, Yonsei University, 120 749, Seoul, South Korea
    Mol Cell 8:9-19. 2001
    ..Therefore, the activator-Mediator interaction likely underlies the initiation of signal transfer from enhancer-bound activators to the basal transcription machinery...
  10. pmc BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
    Alan R Schoenfeld
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1130, New York, NY 10029, USA
    Mol Cell Biol 24:7444-55. 2004
    ....
  11. pmc Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
    P Pichierri
    Laboratorio di Citogenetica Molecolare e Mutagenesi, DABAC, , 01100 Viterbo, Italy
    Mol Biol Cell 12:2412-21. 2001
    ..Our findings support the hypothesis that WRN could be involved in the correct resolution of recombinational intermediates that arise from replication arrest due to either DNA damage or replication fork collapse...
  12. ncbi Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complications
    R Rahbar
    Department of Otolaryngology and Communication Disorders, The Children's Hospital, Boston, Massachusetts 02115, USA
    Ann Otol Rhinol Laryngol 110:1-6. 2001
    ..This study gives promising findings on the efficacy and safety of mitomycin-C as an adjuvant treatment in the management of selected cases of laryngeal and tracheal stenosis...
  13. ncbi The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
    Katsuhiro Hanada
    Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Nat Struct Mol Biol 14:1096-104. 2007
    ..We suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair...
  14. pmc Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks
    Olivier Sordet
    Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    EMBO Rep 10:887-93. 2009
    ..Thus, we propose that Top1cc produce transcription arrests with R-loop formation and generate DSBs that activate ATM in post-mitotic cells...
  15. ncbi SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis
    Christina Ivins Zito
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    J Cell Physiol 199:227-36. 2004
    ..Taken together, these data indicate that the catalytic activity of SHP-2 is required to regulate the PI3K/Akt pathway and thus likely participates in anti-apoptotic signaling by suppressing caspase 3-mediated apoptosis...
  16. ncbi Intra- and postoperative application of Mitomycin C in the middle meatus reduces adhesions and antrostomy stenosis after FESS
    I Konstantinidis
    2nd University ORL, Department, Papageorgiou Hospital, Thessaloniki, Greece
    Rhinology 46:107-11. 2008
    ..This study assesses the efficacy of topical mitomycin C in the middle meatus, intra- and postoperatively in the prevention of adhesion formation and restenosis of the maxillary sinus antrostomy...
  17. doi Treatment of complete nasal vestibule stenosis with vestibular stents and mitomycin C
    Amanda R Salvado
    Head and Neck Surgery Department, UCLA Medical Center, Los Angeles, CA 90095, USA
    Otolaryngol Head Neck Surg 138:795-6. 2008
  18. ncbi Airway complications from topical mitomycin C
    Elizabeth McCurdy Hueman
    University of Texas Health Science Center San Antonio, TX 78229 3900, USA
    Otolaryngol Head Neck Surg 133:831-5. 2005
    ..The purpose of this study is to report complications related to mitomycin C use in the treatment of glottic and subglottic stenosis. Risk factors associated with these complications are identified...
  19. ncbi Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair
    Mischa G Vrouwe
    Department of Toxicogenetics, Leiden University Medical Center, Postal Zone S 6 P, PO Box 9600, 2300 RC, Leiden
    Hum Mol Genet 16:1478-87. 2007
    ..Repair at the G(1) stage is not affected in CdLS cells. Our studies indicate that CdLS cells have a reduced capacity to tolerate DNA damage, presumably as a result of reduced DNA repair through homologous recombination...
  20. ncbi Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication foci
    M Miura
    Molecular Diagnosis and Therapeutics, Oral and Maxillofacial Radiology, Department of Oral Restitution, Graduate School, Tokyo, Japan
    Exp Cell Res 263:202-8. 2001
    ....
  21. pmc ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    H Zhao
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Mol Cell Biol 21:4129-39. 2001
    ..In addition, this study implicates ATR as a direct upstream activator of Chk1 in human cells...
  22. pmc Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
    Annapaola Franchitto
    Laboratorio di Citogenetica Molecolare e Mutagenesi, DABAC, Universita della Tuscia, 01100 Viterbo, Italy
    J Cell Biol 157:19-30. 2002
    ..Together, these results suggest a relationship between BLM, ATR, and the RMN complex in the response to replication arrest, proposing a role for BLM protein and RMN complex in the resolution of stalled replication forks...
  23. ncbi Can mitomycin C really prevent airway stenosis?
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Laryngoscope 116:440-5. 2006
    ..However, the efficacy of MMC is still debatable, and the potential complications of MMC use have been scarcely reported. We evaluated the efficacy and early complications of MMC in a wound model of the subglottis...
  24. ncbi Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos
    Dan Qiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Dev Brain Res 147:183-90. 2003
    ..At the same time, nicotine promotes trophic actions that protect against neurotoxicants that work through other mechanisms...
  25. ncbi Low-dose mitomycin C as a prophylaxis for corneal haze in myopic surface ablation
    Ivey Thornton
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Ophthalmol 144:673-681. 2007
    ..To evaluate the efficacy of low-dose (0.002%) mitomycin C (MMC) vs no prophylactic MMC (control) in reducing corneal haze after surface laser ablation...
  26. pmc Global profiling of DNA replication timing and efficiency reveals that efficient replication/firing occurs late during S-phase in S. pombe
    Majid Eshaghi
    Systems Biology, Genome Institute of Singapore, Singapore, Singapore
    PLoS ONE 2:e722. 2007
    ..Current studies of genome-wide DNA replication profiles have focused on the DNA replication timing and origin location. However, the replication and/or firing efficiency of the individual origins on the genomic scale remain unclear...
  27. pmc DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs
    T Wada
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori ku, Yokohama 226, Japan
    Genes Dev 12:343-56. 1998
    ..The combination of biochemical studies on DSIF and genetic analysis of Spt4 and Spt5 in yeast, also in this issue, indicates that DSIF associates with RNA Pol II and regulates its processivity in vitro and in vivo...
  28. pmc Activation of dormant origins of DNA replication in budding yeast
    C Santocanale
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK
    Genes Dev 13:2360-4. 1999
    ..These experiments show that some dormant replication origins are competent to fire during S phase and that passage of a replication fork through such origins can inactivate them...
  29. ncbi The role of mitomycin C in preventing synechia and stenosis after endoscopic sinus surgery
    Vijay K Anand
    Department of Otorhinolaryngology Head and Neck Surgery, Weill Cornell Campus of New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    Am J Rhinol 18:311-4. 2004
    ..Mitomycin C (MMC) has been used successfully in other fields to decrease postoperative scar formation. We hypothesize that the topical application of MMC reduces the incidence of stenosis and synechia formation after ESS...
  30. ncbi Kinetics of HCMV immediate early mRNA expression in stably transfected fibroblasts
    Sabine P Snaar
    Department of Molecular Cell Biology, Laboratory for Cytochemistry and Cytometry, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    J Cell Sci 115:321-8. 2002
    ..13 microm(2)/sec from this time on. Thus, it appears that these processes are tightly linked in time and space, with the splicing reaction as a rate-limiting factor...
  31. ncbi Risk factors for adult laryngotracheal stenosis: a review of 74 cases
    Yekaterina Koshkareva
    Dept of Otolaryngology Head and Neck Surgery, Temple University School of Medicine, 3400 N Broad St, Kresge West 102, Philadelphia, PA 19140, USA
    Ann Otol Rhinol Laryngol 116:206-10. 2007
    ..We sought to identify risk factors for and review our experience in the management of adult acquired laryngotracheal stenosis (LTS) at an academic urban medical center...
  32. ncbi Topical mitomycin application after laryngotracheal reconstruction: a randomized, double-blind, placebo-controlled trial
    C J Hartnick
    Department of Pediatric Otolaryngology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arch Otolaryngol Head Neck Surg 127:1260-4. 2001
    ..To explore the effect of mitomycin treatment on the pediatric airway following laryngotracheal reconstruction...
  33. ncbi An investigation of airway wound healing using a novel in vivo model
    J Hardillo
    Department of Oto-Rhino-Laryngology Head and Neck Surgery, University Hospital St. Rafael, K.U. Leuven, Kapucijnenvoer 33, B-3000 Leuven, Belgium
    Laryngoscope 111:1174-82. 2001
    ..CONCLUSIONS: A wound healing model based on tracheal revascularization, isolation, and reimplantation was developed in rabbits. This model allowed us to study the healing of full-thickness mucosal defects inside the airway...
  34. pmc Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo
    Patricia A Loomis
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Institute of Neuroscience, Northwestern University, 303 East Chicago Ave, Chicago, IL 60611, USA
    J Cell Biol 163:1045-55. 2003
    ....
  35. ncbi Human Asf1 regulates the flow of S phase histones during replicational stress
    Anja Groth
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell 17:301-11. 2005
    ....
  36. ncbi Mitomycin-C in the treatment of tracheal cicatrix after tracheal reconstruction
    R F Ward
    Department of Otolaryngology, Cornell University Medical College, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA
    Int J Pediatr Otorhinolaryngol 44:221-6. 1998
    ..To demonstrate the potential use of Mitomycin-C (MMC) in the treatment of difficult and recurrent tracheal stenosis...
  37. ncbi Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells
    O Hjertner
    Institute of Cancer Research and Molecular Biology, and the Section of Hematology, Institute of Environmental Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Blood 97:516-22. 2001
    ..BMP-4 or analogues may be attractive therapeutic agents in MM because of possible beneficial effects on both tumor burden and bone disease...
  38. ncbi Monte Carlo simulations and measurement of DNA damage from x-ray-triggered auger cascades in iododeoxyuridine (IUdR)
    S J Karnas
    Department of Medical Biophysics, University of Western Ontario, London, Canada
    Radiat Environ Biophys 40:199-206. 2001
    ..The accentuated DNA damage may have major consequences for cell survival and may be exploitable in kilovoltage photon activation therapy (PAT) of tumors sensitized with iodine...
  39. ncbi p38 MAPK interacts with actin and modulates filament assembly during skeletal muscle differentiation
    Ashwani Khurana
    Signal Transduction Research Laboratory, Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Punjab, India
    Differentiation 71:42-50. 2003
    ..However, inhibition of p38 MAPK completely abolished the anisomycin-mediated actin remodeling. Data suggests that p38 MAPK interacts with actin and modulates actin filament rearrangement in differentiated L6E9 skeletal muscle cells...
  40. ncbi Pathways for clearance of surfactant protein A from the lung
    Deepika Jain
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104 6068, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1011-8. 2005
    ..Thus SP-A clears the lung via a clathrin-mediated pathway that requires the polymerization of actin...
  41. ncbi Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex
    Zhenglin Gu
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Neurosci 25:4974-84. 2005
    ....
  42. ncbi Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro
    J Waschke
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 287:H704-11. 2004
    ....
  43. ncbi Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways
    Claire R Weston
    Signalling Program, The Babraham Institute, Cambridge, UK
    Oncogene 22:1281-93. 2003
    ..This may contribute to Raf- and Ras-induced cell survival at low serum concentrations...
  44. ncbi Integrity of actin-network is involved in uridine 5'-triphosphate evoked store-operated Ca2+ entry in bovine adrenocortical fasciculata cells
    Masahiro Kawamura
    Department of Pharmacology I, Jikei University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 91:23-33. 2003
    ....
  45. ncbi T-cadherin protects endothelial cells from oxidative stress-induced apoptosis
    Manjunath B Joshi
    Department of Research, Cardiovascular Laboratories, Basel University Hospital, Basel, Switzerland
    FASEB J 19:1737-9. 2005
    ..ROS-induced changes in T-cad expression may play an important role in controlling tissue cellularity during vascular remodeling...
  46. ncbi Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1
    Kayoko Nishi
    Department of Biological Chemistry Schol of Medicine, University of Davis, Davis, California 95616, USA
    Exp Cell Res 280:233-43. 2002
    ..The results indicate that the cell shape change caused by staurosporine correlates with the accumulation of p27kip1 and that staurosporine interferes with the p27kip1-specific proteolysis activity...
  47. ncbi Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated
    Ignacio A Romero
    Endothelial and Epithelial Cell Biology Unit, Department of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Brain Res Mol Brain Res 105:47-59. 2002
    ..Together these data suggest that ICAM-1 is not directly associated with ezrin and moesin in brain microvascular endothelial cells...
  48. ncbi Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells
    Dmitry Kondrikov
    Department of Medicine, Universityof Florida College of Medicine, Gainesville, FL 32610, USA
    Am J Physiol Lung Cell Mol Physiol 290:L41-50. 2006
    ..Yeast two-hybrid experiments suggested strong association between eNOS oxygenase domain and beta-actin. These results indicate increase in eNOS association with actin is responsible for greater eNOS activity in confluent PAEC...
  49. ncbi Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement
    Claudio Festuccia
    Department of Experimental Medicine, University of L Aquila, Italy
    Exp Cell Res 280:1-11. 2002
    ..This finding supports the idea that cellular responses to growth factors may be driven by cell-matrix interactions and stresses the role of neuroendocrine factors in prostate carcinoma progression...
  50. ncbi The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members
    Melanie Bausen
    Department of Neurochemistry, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
    Mol Cell Neurosci 31:376-86. 2006
    ..Our data suggest that Mena binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments...
  51. ncbi IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Japan
    Biochem Biophys Res Commun 297:329-34. 2002
    ..The enhanced NO production by IL-15 was inhibited by AMT, an iNOS-specific inhibitor. These results suggest that IL-15 is a potent regulator of iNOS expression by HGEC and involved in innate immunity in the mucosal epithelium...
  52. ncbi Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase
    Nobuo Watanabe
    Department of Environmental Health Sciences, School of Public Health and Center for Free Radical Biology, University of Alabama at Birmingham, RPHB 317, 1530 3rd Ave S, Birmingham, AL 35294 0022, USA
    Arch Biochem Biophys 405:231-40. 2002
    ....
  53. ncbi Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1
    Mingzhe Zheng
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    J Cell Sci 119:96-103. 2006
    ..These results suggest that the adhesion-dependent actin organization regulates proteasomal turnover of HEF1 through the activity of PP2A...
  54. ncbi Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils
    Masayuki Niwa
    Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasamachi, Gifu 500 8705, Japan
    Eur J Pharmacol 466:245-53. 2003
    ..These results strongly suggest that TNF-alpha may act as the regulator of HSP27 induction in neutrophils. p38 MAP kinase (but not p44/p42 MAP kinase) and PKC take part in TNF-alpha-stimulated HSP27 induction in human neutrophils...
  55. ncbi 2-Aminoethoxydiphenyl borate perturbs hormone-sensitive calcium stores and blocks store-operated calcium influx pathways independent of cytoskeletal disruption in human A549 lung cancer cells
    Shanthala Padar
    Department of Physiology and Pharmacology, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA
    Biochem Pharmacol 69:1177-86. 2005
    ..Our study describes novel cytoskeletal-independent effects of 2-APB on Ca2+-signaling pathways, revealing differentially sensitive Ca2+-influx pathways and long-term perturbation of hormone-sensitive Ca2+ stores...
  56. pmc An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewal
    Agnieszka K Rzadzinska
    Section on Structural Cell Biology, National Institute of Deafness and Other Communication Disorders, National Institutes of Health, Bldg 50 Rm 4249, 50 South Dr, Bethesda, MD 20892 8027, USA
    J Cell Biol 164:887-97. 2004
    ..We argue that actin renewal in the paracrystal follows a treadmill mechanism, which, together with the myosins, dynamically shapes the functional architecture of the stereocilia bundle...
  57. ncbi The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho
    Zachary A Pfeiffer
    Department of Biomecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706 0450, USA
    J Leukoc Biol 75:1173-82. 2004
    ..These data support a model wherein p38- and Rho-dependent pathways are critical for P2X7-dependent actin reorganization and membrane blebbing, thereby facilitating P2X7 involvement in macrophage inflammatory responses...
  58. ncbi Cytoskeletal changes of mesenchymal stem cells during differentiation
    Gregory Yourek
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA
    ASAIO J 53:219-28. 2007
    ..These data suggest human mesenchymal stem cells alter their cytoskeletal components during differentiation. Additional studies will address the mechanisms of cytoskeletal changes using biochemical and biophysical methods...
  59. ncbi Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton
    Nathalie Launay
    EA 300 Stress et Pathologies du Cytosquelette, UFR de Biochimie, Universite Paris 7, 2 place Jussieu, 75005 Paris, France
    Exp Cell Res 312:3570-84. 2006
    ..Thus, disturbance of cytoskeleton leads by converging signaling pathways to the phosphorylation of alphaB-crystallin, which probably acts as a protective effector of the cytoskeleton...
  60. ncbi Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes
    Leeni Koivisto
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
    Exp Cell Res 293:68-80. 2004
    ..We conclude that extended lamellipodia formation in keratinocytes requires actin and tubulin assembly at the leading edge, and this process is regulated by Rac1 downstream of GSK-3...
  61. ncbi Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components
    Brian P Head
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:26391-9. 2006
    ..We conclude that microtubules and actin filaments restrict cAMP formation by regulating the localization and interaction of GPCR-G(s)-AC in lipid rafts/caveolae...
  62. ncbi Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets
    Juan A Rosado
    Department of Physiology, University of Extremadura, 10071 Caceres, Spain
    J Biol Chem 279:29231-5. 2004
    ....
  63. ncbi Corneal fibroblasts respond rapidly to changes in local mechanical stress
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 45:3466-74. 2004
    ..To investigate the response of corneal fibroblasts to local changes in extracellular matrix (ECM) tension...
  64. ncbi Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis
    Ioannis P Nezis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
    Cell Motil Cytoskeleton 60:14-23. 2005
    ..Interestingly, the mutated egg chambers are protected by staurosporine-induced apoptosis in a percentage of 40%, strongly suggesting the essential role of dcp-1 and/or pita during mid-oogenesis...
  65. pmc The effect of actin disrupting agents on contact guidance of human embryonic stem cells
    Sharon Gerecht
    Harvard M I T Division of Health Sciences and Technology, USA
    Biomaterials 28:4068-77. 2007
    ..These findings further demonstrate the importance of interplay between cytoskeleton and substrate interactions as a key modulator of morphological and proliferative cellular response in hESCs on nanotopography...
  66. ncbi Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cells cultured in vitro
    Atsushi Hinoue
    Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Anat Rec A Discov Mol Cell Evol Biol 282:130-7. 2005
    ..The spatially and temporally regulated expression of proteinases may be essential for the differentiation and migration of neural crest cells...
  67. ncbi Mathematical modeling of airway epithelial wound closure during cyclic mechanical strain
    Ushma Savla
    Department of Biomedical Engineering, Northwestern University, Chicago, Illinois 60208, USA
    J Appl Physiol 96:566-74. 2004
    ..The contributions of spreading, migration, and mitosis were investigated both numerically and experimentally by using cytochalasin D to inhibit cell motility and mitomycin C to inhibit proliferation...
  68. ncbi Fate of Streptococcus pyogenes and epithelial cells following internalization
    Mehran J Marouni
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Med Microbiol 53:1-7. 2004
    ..Concomitantly, intracellular and, apparently, extracellular free bacteria induce apoptosis through their cytotoxic activity, and release essential nutrients required for their growth...
  69. ncbi Topical application of drugs influencing cytoskeleton and cell contractility affects alveolar bone loss in rats
    Avinoam Yaffe
    Department of Prosthodontics, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    J Periodontol 77:826-31. 2006
    ....
  70. ncbi Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors
    Asad Zeidan
    Division of Molecular and Cellular Physiology, Department of Physiological Sciences, Biomedical Center, Lund University, SE 221 84 Lund, Sweden
    Am J Physiol Cell Physiol 284:C1387-96. 2003
    ..Stretch-dependent differentiation marker expression requires an intact cytoskeleton for stretch sensing, control of protein expression via the level of unpolymerized G-actin, or both...
  71. ncbi Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2
    Anne Marie Preaux
    Institut National de la Santé et de la Recherche Médicale U99, Hopital Henri Mondor, Creteil, France
    Hepatology 36:615-22. 2002
    ..In conclusion, apoptosis of hepatic myofibroblasts induces pro-MMP-2 activation through increased MT1-MMP expression. HEPATOLOGY 2002;36:615-622.)..
  72. ncbi Inducible nitric oxide synthase in vascular smooth muscle cells from prehypertensive spontaneously hypertensive rats
    A Singh
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 9:867-77. 1996
    ..These differences between VSMC from prehypertensive SHR and WKY may indicate a pathophysiological role of iNOS in early blood pressure elevation in SHR...
  73. ncbi Dynamics of integrin clustering at focal contacts of endothelial cells studied by multimode imaging microscopy
    K Kawakami
    Department of Physiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Showa-ku, Nagoya Aichi 4668550, Japan
    J Cell Sci 114:3125-35. 2001
    ..These results suggest that the clustering of integrins is mediated by actin-fiber-dependent translocation of integrins to the extending tip of focal contacts...
  74. ncbi Mechanisms of internalization and recycling of the chemokine receptor, CCR5
    Anja Mueller
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, UK
    Eur J Biochem 271:243-52. 2004
    ..These data indicate that CCR5 internalization and recycling are regulated by actin polymerization and activation of small G proteins in a Rho-dependent manner...
  75. ncbi Coordinated regulation of procollagens I and III and their post-translational enzymes by dissipation of mechanical tension in human dermal fibroblasts
    C A Lambert
    Laboratory of Connective Tissues Biology, , Belgium
    Eur J Cell Biol 80:479-85. 2001
    ....
  76. doi The geodiamolide H, derived from Brazilian sponge Geodia corticostylifera, regulates actin cytoskeleton, migration and invasion of breast cancer cells cultured in three-dimensional environment
    Vanessa M Freitas
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Cell Physiol 216:583-94. 2008
    ..The fact that normal cell lines were not affected by treatment with geodiamolide H stimulates new studies towards therapeutic use for this peptide...
  77. ncbi The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis
    K Lauber
    Department of Internal Medicine I, , , Germany
    J Biol Chem 276:29772-81. 2001
    ..Due to the partial loss of its CARD, the p84 multimer was devoid of caspase-9 or other caspase activity. Thus, our data indicate that Apaf-1 cleavage causes the release of caspases from the apoptosome in the course of apoptosis...
  78. ncbi Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells
    D Leopoldt
    Department of Medicine, School of Medicine and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    J Cell Physiol 188:106-19. 2001
    ..Thus, calyculin-A induces transient focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin, acting downstream of ROK...
  79. ncbi beta1 integrin and organized actin filaments facilitate cardiomyocyte-specific RhoA-dependent activation of the skeletal alpha-actin promoter
    L Wei
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 15:785-96. 2001
    ..These observations support the concept that RhoA regulates SRF-dependent cardiac gene expression through cross-talk with beta1 integrin signal pathway via an organized actin cytoskeleton...
  80. ncbi The role of actin filaments and microtubules in hepatocyte spheroid self-assembly
    E S Tzanakakis
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, 55455, USA
    Cell Motil Cytoskeleton 48:175-89. 2001
    ..The results provide insight into the mechanisms that cells employ to organize into tissues and can contribute to our understanding of how to control the cellular assembly in tissue engineering and clinical applications...
  81. pmc Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity
    D Frey
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    J Cell Biol 149:1443-54. 2000
    ....
  82. pmc Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes
    Yi Duan
    Department of Cellular and Molecular Physiology, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:11418-23. 2008
    ....
  83. ncbi A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblasts
    P D Arora
    Medical Research Council Group in Periodontal Physiology, The Faculty of Dentistry, and the Faculty of Medicine, Division of Respirology, University of Toronto, Toronto M5S 3E8, Ontario, Canada
    J Biol Chem 275:35432-41. 2000
    ..These studies demonstrate that the cellular machinery required for intracellular collagen degradation in fibroblasts closely resembles the vacuolar system in macrophages...
  84. ncbi Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuli
    A McCahill
    Institute of Biomedical and Life Sciences, University of Glasgow, Scotland
    Mol Cell Biochem 208:77-87. 2000
    ....
  85. ncbi Regulation of calcineurin by growth cone calcium waves controls neurite extension
    N J Lautermilch
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 20:315-25. 2000
    ..The results identify components of the cascade by which Ca(2+) waves act to regulate neurite extension...
  86. ncbi Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins
    F Degraeve
    , Service de Pharmacologie et d'Immunologie, 91191 Gif sur Yvette, France
    J Biol Chem 276:46849-55. 2001
    ..These results demonstrate that statins up-regulate COX-2 expression and subsequent prostacyclin formation in human aortic smooth muscle cells in part through inhibition of Rho...
  87. ncbi [Cytoskeletal control of cell length regulation]
    M A Kharitonova
    Cancer Research Center, Russian Academy of Medical Sciences, Kashirskove shosse 24, Moscow, 115478 Russia
    Ontogenez 33:50-9. 2002
    ....
  88. ncbi Ca(2+) removal mechanisms in freshly isolated rabbit aortic endothelial cells
    X Wang
    Department of Pharmacology and Therapeutics, Vancouver Vascular Biology Research Center, University of British Columbia, Vancouver, Canada V6T 1Z3
    Cell Calcium 31:265-77. 2002
    ..These data suggest that in endothelial cells NCX and SERCA function in series to remove about half of the free Ca(2+) from the cytosol, while PMCA contributes to the other half of the Ca(2+) removal process...
  89. pmc Maintenance of the filamentous actin cytoskeleton is necessary for the activation of store-operated Ca2+ channels, but not other types of plasma-membrane Ca2+ channels, in rat hepatocytes
    Ying Jie Wang
    Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
    Biochem J 363:117-26. 2002
    ....
  90. ncbi Cytoskeletal inhibitors, anti-adhesion molecule antibodies, and lectins inhibit hepatocyte spheroid formation
    Masaki Nakamura
    Department of Internal Medicine I, Okayama University Medical School, Japan
    Acta Med Okayama 56:43-50. 2002
    ..Based on the interactions between lectins and hepatocytes in the present study, hepatocytes appear to contain an N-linked complex or N-linked hybrid glycosylated chains...
  91. ncbi Role of the cytoskeleton in secretion of chloride by shark rectal gland
    P Silva
    Mount Desert Island Biological Laboratory, Salsbury Cove, Maine, MA 04670, USA
    J Comp Physiol B 172:719-23. 2002
    ....
  92. ncbi The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c
    Natalie O Karpinich
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:16547-52. 2002
    ..The activation of p53 increases Bax synthesis. The translocation of Bax to the mitochondria induces the MPT, the event that releases cytochrome c and culminates in the death of the cells...
  93. ncbi Distinct pathways in the over-expression of matrix metalloproteinases in human fibroblasts by relaxation of mechanical tension
    C A Lambert
    Laboratory of Connective Tissues Biology, , Tour of Pathology B23/3, 4000 Sart Tilman, , Belgium
    Matrix Biol 20:397-408. 2001
    ..These results point to the potent regulation operated by the status of the cytoskeleton on the cell phenotype, and to distinct regulatory pathways involved in the control of different MMPs expression...
  94. ncbi Actin filament turnover removes bundles from Drosophila bristle cells
    Gregory M Guild
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    J Cell Sci 115:641-53. 2002
    ..We propose that after cell elongation, maintenance falls behind turnover, resulting in the removal of this modular cytoskeleton...
  95. ncbi Cell surface trafficking of Fas in NIT-1 cells and dissection of surface and total Fas expression
    P Augstein
    Gerhardt Katsch Institute of Diabetes Karlsburg e V, Greifswalder Strasse 11e, 17495 Karlsburg, Germany
    Biochem Biophys Res Commun 290:443-51. 2002
    ..It is concluded that inflammatory insults specifically induce translocation of Fas to the beta-cell surface and that interference with cell surface Fas expression is a new strategy to improve beta-cell survival in inflamed islets...
  96. ncbi Role of the actin cytoskeleton in store-mediated calcium entry in glioma C6 cells
    Pawelz Sabała
    Laboratory of Signal Transduction, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Str, Warsaw, Poland
    Biochem Biophys Res Commun 296:484-91. 2002
    ..While the agonists evoke a store-mediated Ca2+ entry that is dependent on the actin cytoskeleton, thapsigargin apparently activates an additional mechanism, which is independent of the disruption of the cytoskeleton...
  97. ncbi Centrosome cohesion is regulated by a balance of kinase and phosphatase activities
    P Meraldi
    Department of Cell Biology, Max-Planck-Institute for Biochemistry, D-82152 Martinsried, Germany
    J Cell Sci 114:3749-57. 2001
    ..These studies highlight the importance of protein phosphorylation in the control of centrosome cohesion, and they point to Nek2 and PP1 alpha as critical regulators of centrosome structure...
  98. ncbi Synergistic enhancement of apoptosis by DNA- and cytoskeleton-damaging agents: a basis for combination chemotherapy of cancer
    X Shang
    National Institute of Bioscience and Human Technology, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Anticancer Res 21:2585-9. 2001
    ..03. Thus, apoptosis in many tumor cell lines is synergistically enhanced by various combinations of DNA- and cytoskeleton-damaging agents...
  99. ncbi Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors
    J L Arbiser
    Division of Endocrinology, Children s Hospital, Boston, MA 02115
    Endocr J 40:263-8. 1993
    ..This indicates that the downregulation of c-myc gene expression is insufficient to stimulate the expression of all the placental genes stimulated by MTX...
  100. ncbi Effects of inhibitors of RNA and protein synthesis on the subcellular distribution of the eukaryotic translation initiation factor, eIF-5A, and the HIV-1 Rev protein
    X P Shi
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Biol Signals 6:143-9. 1997
    ..Our findings are consistent with our previous conclusion that eIF-5A is associated with the ER through ribosomes and support a role for eIF-5A in protein synthesis...
  101. pmc Human cytomegalovirus replicates abortively in polymorphonuclear leukocytes after transfer from infected endothelial cells via transient microfusion events
    G Gerna
    Servizio di Virologia, Area Infettivologica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy
    J Virol 74:5629-38. 2000
    ....

Research Grants100

  1. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2005
    ..Structural parameters in the meshwork and ciliary muscle/processes of intact eyes will be evaluated by light/electron microscopy, immunohistochemistry and quantitative morphometry. ..
  2. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2000
    ..Cholinergic/adrenergic receptor subtypes will be identified, quantified and localized by ligand binding, autoradiography and in situ hybridization in untouched eyes and following the various perturbations. ..
  3. Mechanism of sgk action in the collecting duct
    Geza Fejes Toth; Fiscal Year: 2005
    ..abstract_text> ..
  4. The population genetics of antibiotic resistance in multi-drug environments
    Roy Kishony; Fiscal Year: 2009
    ..Our research will reveal the mechanism underlying these important drug-drug interactions. ..
  5. CENTRAL SYNAPTIC TRANSMISSION
    DIANE O DOWD; Fiscal Year: 2002
    ....
  6. REGULATION OF P53 STABILITY BY SER315 PHOSPHORYLATION
    Mats Ljungman; Fiscal Year: 2002
    ..We will express wild-type or mutant CDC14 in MCF7 cells and study what effect it will have on basal and induced levels of p53. ..
  7. Molecular mechanism of antibiotic rifampicin action
    Irina Artsimovitch; Fiscal Year: 2006
    ..Finally a set of rules for design of more potent rifamycin-like antibiotics will be formulated to achieve the long-term goal of knowledge-based creation of the new generation of antibacterial drugs. ..
  8. Vascular mimetics to study inflammation and atherosclerosis
    SCOTT IRWIN contact SIMON; Fiscal Year: 2010
    ..This would reflect a person's metabolic profile and correlate with their propensity to develop atherosclerosis and heart disease. ..
  9. Assessment of Corneal Fibroblast Biomechanical Behavior
    W Petroll; Fiscal Year: 2005
    ....
  10. INDUCTION OF MAMMARY CANCER BY SIGNALING MOLECULES
    Steven Anderson; Fiscal Year: 2003
    ..These studies will provide new information about the effect of the prolactin receptor upon mammary epithelial cells, and whether suppression of apoptosis in Important in mammary carcinogenesis. ..
  11. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  12. Podocyte Protein Alterations Induced by Glucocorticoids
    Richard Ransom; Fiscal Year: 2005
    ..Identification of a potential mechanism for glucocorticoid action in the treatment of NS would permit the development of more highly targeted and less toxic therapies for this very common form of kidney disease. ..
  13. CYTOTOXIC NITROGEN HETEROCYCLES
    Edwin Vedejs; Fiscal Year: 2000
    ..5) intramolecular organometallic coupling of activated aziridines to assemble the aziridinomitosene. and (6) peptide bond assembly using amidines as agents for nitrogen activation. ..
  14. TRANSLATIONAL CONTROL MEDIATED BY MRNA STRUCTURE
    Marilyn Kozak; Fiscal Year: 1993
    ..If ribosomes can be induced to reinitiate translation in vitro, the requirements for reinitiation will be studied...
  15. Chemical Approaches to Protein Arginine Methylation
    Yujun Zheng; Fiscal Year: 2010
    ..This effort is of great significance for the development of potent PRMT inhibitors to treat prostate carcinoma and other diseases associated with the deregulation of protein arginine methylation. ..
  16. Molecular and Force dynamics of leukocyte adhesion molecules
    Scott Simon; Fiscal Year: 2007
    ..abstract_text> ..
  17. THERAPY FOR GASTROINTESTINAL DISORDERS
    Elizabeth Dial; Fiscal Year: 2002
    ..Development of this therapeutic potential for rhLF will fulfill a crucial need for a way to safely administer NSAIDs. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  18. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  19. Molecular and Force Dynamics: Leukocyte Adhesion Molecules
    Scott Simon; Fiscal Year: 2009
    ..These studies will elucidate the adhesive and migratory processes relevant to acute and chronic inflammation. ..
  20. Zinc transport and homeostasis in cortical neurons
    Robert Colvin; Fiscal Year: 2002
    ..What is the identity of Zn2+ containing compartments in the cell body and processes of cortical neurons?..
  21. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David Brown; Fiscal Year: 2009
    ....
  22. Pulmonary Hypertension in Thalassemia
    SYLVIA SINGER; Fiscal Year: 2007
    ....
  23. Biochemical analysis of Pol II elongation complexes and mechanism
    CRAIG KAPLAN; Fiscal Year: 2007
    ..Insights into Pol II function will allow a better understanding of how Pol II may be misregulated in disease states in other species, such as humans. ..