cyclooxygenase inhibitors

Summary

Summary: Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

Top Publications

  1. ncbi Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 22:383-90. 2008
  2. doi Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events
    James M Scheiman
    Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
    Clin Ther 32:667-77. 2010
  3. ncbi Cyclooxygenases: structural, cellular, and molecular biology
    W L Smith
    Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
    Annu Rev Biochem 69:145-82. 2000
  4. ncbi Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    Pratima Sinha
    Department of Biological Sciences, University of Maryland Baltimore County, University of Maryland, Baltimore, Maryland 21250, USA
    Cancer Res 67:4507-13. 2007
  5. ncbi The role of cyclooxygenases in inflammation, cancer, and development
    C S Williams
    Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    Oncogene 18:7908-16. 1999
  6. doi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
  7. ncbi Anti-inflammatory cembranoids from the soft corals Sinularia querciformis and Sinularia granosa
    Yi Lu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1754-9. 2008
  8. ncbi Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association
    Elliott M Antman
    Brigham and Women s Hospital, Harvard Medical School, USA
    Circulation 115:1634-42. 2007
  9. ncbi Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer
    Sherven Sharma
    Department of Medicine, Lung Cancer Research Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1960, USA
    Cancer Res 65:5211-20. 2005
  10. pmc COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells
    Mitsugu Fujita
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 71:2664-74. 2011

Research Grants

  1. FETAL REFLEX RESPONSES TO CEREBRAL HYPOPERFUSION
    Charles Wood; Fiscal Year: 1999
  2. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
  3. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1990
  4. EICOSANOIDS IN GALLBLADDER PHYSIOLOGY AND DISEASE
    DONALD KAMINSKI; Fiscal Year: 1991
  5. Aspects of Biotin Nutrition
    Donald M Mock; Fiscal Year: 2010
  6. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2009
  7. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2009
  8. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
  9. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1990
  10. CELLULAR MECHANISMS OF CHOLECYSTITIS AND COLITIS
    DONALD KAMINSKI; Fiscal Year: 1999

Detail Information

Publications352 found, 100 shown here

  1. ncbi Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 22:383-90. 2008
    ..In view of its substantial COX-2 inhibition, recently defined cardiovascular warnings for use of COX-2 inhibitors should also be considered for acetaminophen...
  2. doi Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events
    James M Scheiman
    Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
    Clin Ther 32:667-77. 2010
    ..However, NSAIDs have been associated with gastrointestinal (GI) toxicity. The cardiovascular (CV) toxicity associated with COX-2 inhibitors and some other NSAIDs further complicates the choice of therapy...
  3. ncbi Cyclooxygenases: structural, cellular, and molecular biology
    W L Smith
    Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
    Annu Rev Biochem 69:145-82. 2000
    ..We further examine the evidence for independent signaling by PGHS-1 and PGHS-2, and the complex mechanisms for regulation of PGHS-2 gene expression...
  4. ncbi Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    Pratima Sinha
    Department of Biological Sciences, University of Maryland Baltimore County, University of Maryland, Baltimore, Maryland 21250, USA
    Cancer Res 67:4507-13. 2007
    ....
  5. ncbi The role of cyclooxygenases in inflammation, cancer, and development
    C S Williams
    Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    Oncogene 18:7908-16. 1999
    ..The in vivo mechanism by which COX-2 affects tumor growth has not been determined. It is possible that both tumor and stromally derived COX-2 could influence tumor angiogenesis and/ or immune function...
  6. doi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
  7. ncbi Anti-inflammatory cembranoids from the soft corals Sinularia querciformis and Sinularia granosa
    Yi Lu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1754-9. 2008
    ..However, compounds 3, 7, and 8 significantly inhibited the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells...
  8. ncbi Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association
    Elliott M Antman
    Brigham and Women s Hospital, Harvard Medical School, USA
    Circulation 115:1634-42. 2007
  9. ncbi Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer
    Sherven Sharma
    Department of Medicine, Lung Cancer Research Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1960, USA
    Cancer Res 65:5211-20. 2005
    ..Transfer of Treg cells or administration of PGE2 to mice receiving COX-2 inhibitors reversed these effects. We conclude that inhibition of COX-2/PGE2 suppresses Treg cell activity and enhances antitumor responses...
  10. pmc COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells
    Mitsugu Fujita
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 71:2664-74. 2011
    ..Taken together, our findings show that the COX-2 pathway promotes gliomagenesis by directly supporting systemic development of MDSCs and their accumulation in the TME, where they limit CTL infiltration...
  11. pmc Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast
    Min Hu
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:3372-7. 2009
    ....
  12. pmc Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, New Orleans, LA, USA
    J Exp Med 202:931-9. 2005
    ..Furthermore, an addition of arginase I represents a clinical approach to enhance the therapeutic potential of cancer immunotherapies...
  13. doi COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps
    Yuki Nakanishi
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto606 8507, Japan
    Carcinogenesis 32:1333-9. 2011
    ..Thus, our results suggest that COX-2 inhibition alters TAM phenotype in an IFN-γ-dependent manner and subsequently may reduce intestinal tumor progression...
  14. ncbi Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 369:1603-13. 2007
    ..However, the delay from the early development of adenoma to presentation with cancer is at least 10 years. We aimed to assess the longer-term effect of aspirin on the incidence of cancers...
  15. ncbi Cardiovascular safety of lumiracoxib: a meta-analysis of all randomized controlled trials > or =1 week and up to 1 year in duration of patients with osteoarthritis and rheumatoid arthritis
    Patrice Matchaba
    Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA
    Clin Ther 27:1196-214. 2005
    ..The cardiovascular (CV) safety of non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors has been the subject of considerable debate...
  16. ncbi Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia
    JAMA 296:1633-44. 2006
    ..Regulatory agencies have provided variable advice regarding the cardiovascular risks with older nonselective NSAIDs...
  17. ncbi Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma
    Brian I Rini
    Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Cancer 106:566-75. 2006
    ..Based on potential additive or synergistic antitumor effects, interferon-alpha (IFNalpha) and celecoxib, an oral COX-2 inhibitor, were given to metastatic RCC patients in a Phase II trial...
  18. ncbi Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis
    R C Reddy
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0360, USA
    Am J Physiol Lung Cell Mol Physiol 281:L537-43. 2001
    ..These results demonstrate that selective COX-2 inhibition confers early but not long-term benefits without affecting the expression of proinflammatory cytokines or the development of lung inflammation...
  19. pmc Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
    Julia Hippisley-Cox
    Institution 13th floor, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 330:1366. 2005
    ....
  20. ncbi Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2
    Ruxana T Sadikot
    Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
    Eur J Immunol 37:1001-9. 2007
    ..Thus it is possible that inhibition of COX-2 or EP2 receptors could be an effective adjunctive treatment for severe or resistant P. aeruginosa pneumonia...
  21. ncbi Coxibs and cardiovascular disease
    Garret A Fitzgerald
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 351:1709-11. 2004
  22. pmc COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia
    M Farooqui
    1Division of Hematology, Oncology and Transplantation, the Vascular Biology Center, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Br J Cancer 97:1523-31. 2007
    ..In fact, the combination provided significantly better analgesia than with morphine or celecoxib alone. Clinical trials of this combination for analgesia in chronic and severe pain in cancer are warranted...
  23. doi Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort study
    Anne Marie Schjerning Olsen
    Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark
    Circulation 123:2226-35. 2011
    ..We therefore studied the duration of NSAID treatment and cardiovascular risk in a nationwide cohort of patients with prior myocardial infarction (MI)...
  24. ncbi Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions
    Hedi Harizi
    Laboratoire d Immunologie, Unité Mixte de Recherche Centre National de la Recherche Scientifique, Universite Victor Segalen, Bordeaux 2, 33076 Bordeaux, France
    J Immunol 168:2255-63. 2002
    ..We conclude that COX-2-mediated PGE(2) up-regulates IL-10, which down-regulates IL-12 production and the APC function of BM-DC...
  25. pmc IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    S Kotake
    The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Clin Invest 103:1345-52. 1999
    ....
  26. doi Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes
    Oliver Goldmann
    Infection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 185:2372-81. 2010
    ..pyogenes infected mice. Therefore, the results of this study open up new perspectives on potential molecular pathways that are prone to pharmacological manipulation during severe streptococcal infections...
  27. doi Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis
    Matthew C Becker
    Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
    Am Heart J 157:606-12. 2009
    ..Pain management in patients with osteoarthritis or rheumatoid arthritis often requires long-term use of nonsteroidal antiinflammatory drugs (NSAIDs). However, the relative cardiovascular safety of these therapies remains uncertain...
  28. doi Gait analysis and pain response of two rodent models of osteoarthritis
    C E Ferland
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, Saint Hyacinthe, Canada
    Pharmacol Biochem Behav 97:603-10. 2011
    ..These results suggest that the MIA model may be more appropriate for the evaluation of short term pain studies and that celecoxib may modulate mechanical allodynia through central sensitization mechanisms...
  29. ncbi Cyclooxygenase as a target for colorectal cancer chemoprevention
    Leticia Moreira
    Gastroenterology Department, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Catalonia, Spain
    Curr Drug Targets 12:1888-94. 2011
    ....
  30. doi Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance
    Bing Liu
    Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, Zhejiang, People s Republic of China
    Cell Biol Int 34:21-5. 2010
    ..Therefore we can use the COX inhibitors to potentialize the effects of chemotherapeutic agents and reverse multidrug resistance to facilitate the patient who may benefit from addition of COX inhibitors to standard cytotoxic therapy...
  31. doi Cyclo-oxygenase 2 inhibitors and the risk of anastomotic leakage after fast-track colonic surgery
    K Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Br J Surg 96:650-4. 2009
    ..This study determined the rate of anastomotic leakage in a series of patients who had colonic surgery over a 9-year period with or without use of a cyclo-oxygenase inhibitor for postoperative analgesia...
  32. doi NSAIDs and the colon
    Angel Lanas
    Service of Digestive Diseases, University Hospital, CIBERehd IACS, University of Zaragoza, Zaragoza, Spain
    Curr Opin Gastroenterol 25:44-9. 2009
    ..To better understand the effects of NSAIDs on the colon...
  33. ncbi Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis
    Jing Leng
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 38:756-68. 2003
    ..01). In conclusion, our results suggest the involvement of COX-2-dependent and -independent mechanisms in celecoxib-mediated HCC cell apoptosis...
  34. pmc Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention
    Susan M Fischer
    Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, PO Box 389, Smithville, TX 78957, USA
    Cancer Prev Res (Phila) 4:1728-35. 2011
    ..A comprehensive understanding of the results of coxibs and other NSAIDs in animal studies may help inform and shape human trials of these commonly employed, relatively inexpensive, and highly effective compounds...
  35. doi Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: a double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group
    Andrea Koch
    Allergy Centre Allergicentrum, University Hospital, Linkoping, Sweden
    Eur J Cancer 47:1546-55. 2011
    ..Experimental and clinical phase II trials have indicated that the addition of the COX-2 inhibitor celecoxib to palliative chemotherapy might increase survival time in patients with advanced NSCLC...
  36. ncbi Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
  37. ncbi Mechanisms behind COX-1 and COX-2 inhibition of tumor growth in vivo
    Hans Axelsson
    Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Int J Oncol 37:1143-52. 2010
    ..In conclusion, our results extend earlier studies on cell culture experiments and demonstrate that EGF-R and downstream KRas pathways communicate effects of increased prostaglandin activity in tumor tissue in vivo...
  38. doi Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer
    Johnny Kao
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York, USA
    Cancer 117:3173-81. 2011
    ..In the current phase 1 trial, the authors sought to determine the maximum tolerated dose (MTD) and efficacy of concurrent erlotinib and celecoxib as a radiosensitizing regimen...
  39. ncbi Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study
    Yana Vinogradova
    Division of Primary Care, University of Nottingham, Nottingham, United Kingdom
    Gastroenterology 133:393-402. 2007
    ..Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use...
  40. ncbi Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient
    L Laine
    University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Gastroenterology 120:594-606. 2001
    ..This review discusses the risks of clinical GI disease in NSAID users, the predictors of increased risk, and strategies for prevention of NSAID-associated GI disease...
  41. ncbi Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    Kathleen M Leahy
    Pharmacia, Mail Zone AA4C, 700 Chesterfield Parkway, Chesterfield, Missouri 63017, USA
    Cancer Res 62:625-31. 2002
    ..2-3.0-fold) in response to celecoxib. Thus, the antitumor activity of celecoxib may be attributable, at least in part, to a direct effect on host stromal elements, such as the angiogenic vasculature...
  42. doi Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip
    A K Jäger
    Department of Medicinal Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Phytother Res 22:982-4. 2008
    ..The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid. Linoleic acid and alpha-linolenic acid contribute to the COX-1 and -2 inhibitory activity of rose hip...
  43. ncbi Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids
    F Catella-Lawson
    University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 289:735-41. 1999
    ..Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1...
  44. ncbi Pathogenesis of aspirin-exacerbated respiratory disease
    Donald D Stevenson
    Allergy and Immunology Division, Scripps Clinic and the Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Rev Allergy Immunol 24:169-88. 2003
    ..It is more likely that a diminution in number or function of cysLT receptors accounts for the diminished inflammatory response found in ASA desensitization...
  45. ncbi Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis
    Caname Iwata
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Res 67:10181-9. 2007
    ..Our findings suggest that COX-2 inhibitor may be useful for prophylaxis of lymph node metastasis by reducing macrophage-mediated tumor lymphangiogenesis...
  46. ncbi Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma
    Christoph Bergmann
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 67:8865-73. 2007
    ..Neutralizing mAbs to IL-10 and/or TGF-beta(1) abolished Tr1-mediated suppression. COX-2 overexpression in HNSCC plays a major role in the induction of Tr1 cells in the tumor microenvironment...
  47. ncbi COX-2: a target for colon cancer prevention
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 42:55-80. 2002
    ..It is hoped that, as the genome sequence is understood more clearly, other targets will emerge that will provide even more effective drugs for future cancer prevention...
  48. ncbi Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer
    N Kundu
    Program in Oncology, University of Maryland Greenebaum Cancer Center and School of Medicine, Baltimore, MD 21201, USA
    Int J Cancer 93:681-6. 2001
    ..Despite the inhibition of prostaglandin synthesis, the cox-2 enzyme levels (protein and mRNA) were increased by either indomethacin or NS398...
  49. doi Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy
    Pharmacol Res 59:90-100. 2009
    ....
  50. ncbi Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice
    Padi S V Satyanarayana
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 28:641-9. 2004
    ..The results demonstrated marked synergistic interaction between naproxen and tramadol and such interaction involved opioid as well as non-opioid mechanisms of tramadol and inhibition of COX-1 but not COX-2 by naproxen...
  51. ncbi Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer
    Sulma I Mohammed
    Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Cancer Res 62:356-8. 2002
    The mechanisms by which cyclooxygenase inhibitors exert antitumor effects are not completely defined but are postulated to involve antiangiogenic effects and induction of apoptosis...
  52. ncbi COX-2 as a target for cancer chemotherapy
    Nilanjan Ghosh
    Dr B C Roy College of Pharmacy and Allied Health Sciences, Durgapur, India
    Pharmacol Rep 62:233-44. 2010
    ..Large epidemiological trials studying users and non-users of aspirin have shown that cyclooxygenase inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) could be of benefit against the development and ..
  53. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
    ..We also compare the concentrations of these inhibitors used in in vitro and in vivo experiments and discuss the implications of the in vitro studies for clinical management of cancer with these drugs...
  54. doi Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial
    Rachel S Midgley
    Department of Clinical Pharmacology, University of Oxford, Headington, Oxford, United Kingdom
    J Clin Oncol 28:4575-80. 2010
    ..The purpose of this study was to test whether the COX-2 inhibitor rofecoxib could reduce recurrence and improve survival when administered in the adjuvant setting of colorectal cancer (CRC)...
  55. ncbi Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay
    U Huss
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, SE 751 23 Uppsala, Sweden
    J Nat Prod 65:1517-21. 2002
    ..This study showed that a COX-2-catalyzed PGE(2) assay using SPA is suitable for screening natural compounds with respect to COX-2 inhibition...
  56. ncbi The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
    N Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munchen, Germany
    Mol Psychiatry 11:680-4. 2006
    ..Moreover, the fact that treatment with an anti-inflammatory drug showed beneficial effects on MD indicates that inflammation is related to the pathomechanism of the disorder, although the exact mechanisms remain to become elucidated...
  57. ncbi Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer
    Jingsong Chu
    Signal Transduction Laboratory, Methodist Research Institute, Indianapolis, Indiana 46202, USA
    Mol Cancer Ther 2:1-7. 2003
    ....
  58. pmc Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials: the cross trial safety analysis
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 117:2104-13. 2008
    ..Our aim was to assess the cardiovascular risk associated with celecoxib in 3 dose regimens and to assess the relationship between baseline cardiovascular risk and effect of celecoxib on cardiovascular events...
  59. pmc Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication
    Hua Zhu
    Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 99:3932-7. 2002
    ..The failure to produce normal levels of this critical viral regulatory protein in the presence of COX-2 inhibitors might block normal progression beyond the immediate-early phase of human cytomegalovirus infection...
  60. doi Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks
    A Rostom
    Division of Gastroenterology, University of Calgary Medical Clinic, AB, Canada
    Aliment Pharmacol Ther 29:481-96. 2009
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, but are not without risks...
  61. ncbi Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities
    S J Baek
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 59:901-8. 2001
    ..These data demonstrate that NAG-1 is an antitumorigenic and proapoptotic protein, and its regulation by COX inhibitors may provide new clues for explaining their proapoptotic and antitumorigenic activities...
  62. ncbi Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity
    Daoyan Wei
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:2030-8. 2004
    ..Collectively, our data provide a novel molecular mechanism for the antitumor activity of celecoxib and may help further improve its effectiveness in controlling pancreatic cancer growth and metastasis...
  63. ncbi Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cancer Res 64:1369-76. 2004
    ....
  64. pmc Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis
    Karin Muller-Decker
    Research Program Tumor Cell Regulation, Deutsches Krebsforschungszentrum, and Department of Pathology, Ruprecht Karls University, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 99:12483-8. 2002
    ..e., dramatically sensitizes the tissue for genotoxic carcinogens...
  65. doi An evidence-based review of the cardiovascular risks of nonsteroidal anti-inflammatory drugs
    Michael E Farkouh
    Mount Sinai Heart Clinical Trials Unit, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 103:1227-37. 2009
    ....
  66. ncbi Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection
    M A Michelin
    Department of Biological Sciences, Immunology, Federal School of Medicine, Uberaba, MG, Brazil
    Exp Parasitol 111:71-9. 2005
    ..In conclusion, the results suggest that the prostaglandins produced mainly by COX-2 mediate the immunosuppression observed in the acute phase of T. cruzi infection...
  67. ncbi Structural and functional basis of cyclooxygenase inhibition
    Anna L Blobaum
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Med Chem 50:1425-41. 2007
  68. ncbi NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2
    J L Wallace
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 119:706-14. 2000
    ..We tested this hypothesis in rats by using a selective COX-1 inhibitor (SC-560)...
  69. pmc Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
    Peter Teismann
    Neuroscience Research Laboratories of the Movement Disorder Division, Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:5473-8. 2003
    ..Because of the safety record of the COX-2 inhibitors, and their ability to penetrate the blood-brain barrier, these drugs may be therapies for PD...
  70. pmc Prevention of both direct and cross-priming of antitumor CD8+ T-cell responses following overproduction of prostaglandin E2 by tumor cells in vivo
    Maryam Ahmadi
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, UK
    Cancer Res 68:7520-9. 2008
    ..In vivo, overexpression of COX-2 by tumor cells results in a decrease in number of tumor-infiltrating dendritic cells and confers the ability of tumor cells to metastasize to the tumor draining lymph nodes...
  71. pmc Non-steroidal anti-inflammatory drugs and myocardial infarctions: comparative systematic review of evidence from observational studies and randomised controlled trials
    P A Scott
    Department of Cardiology, Queen Alexandra Hospital, Portsmouth, UK
    Ann Rheum Dis 66:1296-304. 2007
    ..The comparative risk of myocardial infarction (MI) with cyclo-oxygenase-2-specific drugs and traditional non-steroidal anti-inflammatory drugs (NSAIDs) was determined...
  72. ncbi Ibuprofen in very preterm infants impairs renal function for the first month of life
    Rachel Vieux
    Maternite Regionale, Neonatal Department, Nancy University, Nancy, France
    Pediatr Nephrol 25:267-74. 2010
    ..Renal function of infants receiving ibuprofen should be carefully monitored and drugs that are eliminated by glomerular filtration handled cautiously during this period...
  73. pmc Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
    Jay M Lee
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Crit Rev Oncol Hematol 66:208-17. 2008
    ..The understanding of molecular mechanisms involved in inflammation and lung carcinogenesis provide insight for new drug development that target reversible, non-mutational events in the chemoprevention and treatment of lung cancer...
  74. ncbi Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer
    Leandro C A Cerchietti
    Translational Research Unit, Angel H Roffo Cancer Institute, Universidad de Buenos Aires, Buenos Aires, Argentina
    Nutr Cancer 59:14-20. 2007
    ..This study shows that by modulating the eicosanoid metabolism using a combination of n-3 fatty acids and cyclooxygenase-2 inhibitor, some of the signs and symptoms associated with a SIMS could be ameliorated...
  75. ncbi Celecoxib-loaded poly(D,L-lactide-co-glycolide) nanoparticles prepared using a novel and controllable combination of diffusion and emulsification steps as part of the salting-out procedure
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, UK
    J Microencapsul 23:480-98. 2006
    ....
  76. ncbi Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia
    Giovanni Mantovani
    Department of Medical Oncology, University of Cagliari, Cagliari, Italy
    J Mol Med (Berl) 88:85-92. 2010
    ..Therefore, phase III clinical trials are warranted to test the efficacy and safety of celecoxib...
  77. pmc Breast-cancer-associated metastasis is significantly increased in a model of autoimmune arthritis
    Lopamudra Das Roy
    Department of Immunology, Mayo Clinic School of Medicine, 13400 E, Shea Blvd, Scottsdale, Arizona 85259, USA
    Breast Cancer Res 11:R56. 2009
    ....
  78. ncbi Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid
    Carmine Stolfi
    Dipartimento di Medicina Interna, Universita Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    Biochem Pharmacol 75:668-76. 2008
    ..Taken together our data indicate that 5-ASA causes both a COX-2-dependent and -independent inhibition of CRC cell growth...
  79. ncbi Cardiovascular effects of the cyclooxygenase inhibitors
    William B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT 06030 3940, USA
    Hypertension 49:408-18. 2007
  80. ncbi Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells
    Shahar Lev-Ari
    Department of Cancer Prevention, Tel Aviv Medical Center, Israel
    Clin Cancer Res 11:6738-44. 2005
    ..This study aims to investigate whether curcumin potentiates the growth inhibitory effect of celecoxib, a specific COX-2 inhibitor, in human colon cancer cells...
  81. ncbi Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer
    Jason Gee
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncol Rep 15:471-7. 2006
    ..Induction of apoptosis in all three cell lines by celecoxib was associated with downregulation of Bcl-2. These changes occur independently of COX-2 expression levels suggesting the presence of a COX-2 independent pathway...
  82. ncbi Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial
    V Gournay
    Service de réanimation pédiatrique et néonatale, hôpital de la Mère et de l Enfant, Centre Hospitalier Universitaire CHU de Nantes, quai Moncousu, 44000 Nantes, France
    Lancet 364:1939-44. 2004
    ..We aimed to compare prophylactic and curative ibuprofen in the treatment of this abnormality in very premature infants...
  83. ncbi Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers
    C Bizzarri
    Consorzio Biolaq, L'Aquila, Italy
    Biochem Pharmacol 61:1429-37. 2001
    ..It is concluded that inhibition of IL-8 chemotaxis could represent a new clinical target for ketoprofen isomers and, in fact, contribute to the anti-inflammatory activity of NSAIDs...
  84. ncbi Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line
    Jian Ying Li
    Department of Gastroenterology, Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, China
    World J Gastroenterol 9:915-20. 2003
    ..To evaluate the potential role of Nimesulide, a selective COX-2 inhibitor, in proliferation and apoptosis of gastric adenocarcinoma cells SGC7901...
  85. ncbi Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice
    Tsutomu Sasaki
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    J Cereb Blood Flow Metab 24:107-13. 2004
    ..These results of genetic disruption and chemical inhibition of cyclooxygenase-2 show that inhibition of COX-2 ameliorates selective neuronal death after transient forebrain ischemia in mice...
  86. ncbi Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein
    Seung Joon Baek
    Laboratory of Molecular Carcinogenesis, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 67:356-64. 2005
    ..NAG-1 seems to be an important downstream target protein of this transcription factor, EGR-1, and may mediate the chemopreventive activity of some NSAIDs...
  87. ncbi Cyclooxygenase-2--10 years later
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Pharmacol Exp Ther 300:367-75. 2002
    ..The present review assesses recent advances in COX-2 research, with particular emphasis on new insights into pathophysiological and physiological functions of this isoenzyme...
  88. ncbi Multifaceted roles of cyclooxygenase-2 in lung cancer
    Karen Riedl
    UCLA Lung Cancer Research Program, Department of Medicine, 37 131 CHS, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1690, USA
    Drug Resist Updat 7:169-84. 2004
    ..In addition, delineation of how COX-2-dependent genes modulate the malignant phenotype will provide novel insights in lung cancer pathogenesis...
  89. doi Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection
    Suki M Y Lee
    Department of Microbiology, Siriraj Hospital, Bangkok, Thailand
    J Infect Dis 198:525-35. 2008
    ..These data provide a basis for the possible development of novel therapeutic interventions for the treatment of H5N1 disease, as adjuncts to antiviral drugs...
  90. ncbi Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain
    Jose L M Madrigal
    Department of Pharmacology, Faculty of Medicine, University of Complutense, 28040 Madrid, Spain
    Neuropsychopharmacology 28:1579-88. 2003
    ..These findings are discussed as possible damaging and/or adaptive roles for stress-induced COX-2 in the brain...
  91. ncbi Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis
    Andrew Whelton
    Universal Clinical Research Center, Inc, and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21030 1603, USA
    Am J Cardiol 90:959-63. 2002
    ..7%) compared with the celecoxib group (4.7%) (p <0.05). Thus, in patients with controlled hypertension on a fixed antihypertensive regimen, careful monitoring of BP is warranted after the initiation of celecoxib or rofecoxib therapy...
  92. ncbi The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    J Cancer Res Clin Oncol 128:525-32. 2002
    ....
  93. ncbi Expression of cyclooxygenase 2 in human malignant melanoma
    C Denkert
    Institute of Pathology, , Berlin, Germany
    Cancer Res 61:303-8. 2001
    ..It remains to be investigated whether selective inhibitors of COX-2 might be useful for prevention or treatment of malignant melanoma...
  94. ncbi Inhibition of delayed rectifier potassium channels and induction of arrhythmia: a novel effect of celecoxib and the mechanism underlying it
    Roman V Frolov
    Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14214, USA
    J Biol Chem 283:1518-24. 2008
    ..These observations reveal an unanticipated effect of celecoxib on Drosophila hearts and on heart cells from rats, implicating the inhibition of Kv2 channels as the mechanism underlying this effect...
  95. pmc Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise
    M P Bernard
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Pharm Des 14:2051-60. 2008
    ..Therefore, Cox-2 selective inhibitors have promising therapeutic potential in patients suffering from certain hematological malignancies...
  96. doi Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms
    Khalid Alfaleh
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Pediatrics 121:e233-8. 2008
    ..We also compared the 18-month outcomes of infants with and without a serious pulmonary bleed...
  97. ncbi Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus
    Kenji Kawaguchi
    Department of Neurology, University of Pittsburgh, PA 15260, USA
    Brain Res 1050:130-7. 2005
    ..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective...
  98. ncbi MR monitoring of cyclooxygenase-2 inhibition of angiogenesis in a human breast cancer model in rats
    Laure S Fournier
    Center for Pharmaceutical and Molecular Imaging, University of California, San Francisco, USA
    Radiology 243:105-11. 2007
    ....
  99. doi Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer
    C Falandry
    Department of Medical Oncology, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Ann Oncol 20:615-20. 2009
    ..Careful monitoring during future trials will be necessary to accurately assess the risk-benefit ratio of combination therapy...
  100. ncbi NSAIDs and apoptosis
    N R Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon, India
    Cell Mol Life Sci 65:1295-301. 2008
    ..Both COX-2-dependent and COX-2-independent mechanisms are involved in NSAIDs-induced neoplastic growth. This article reviews the recent literature that has revealed various important mechanisms of NSAIDs-induced apoptosis...
  101. ncbi Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor
    N M Davies
    Faculty of Pharmacy, University of Sydney, New South Wales, Australia
    Clin Pharmacokinet 38:225-42. 2000
    ..As celecoxib is metabolised by CYP2C9, increased clinical vigilance is required during the coadministration of other substrates or inhibitors of this enzyme...

Research Grants66

  1. FETAL REFLEX RESPONSES TO CEREBRAL HYPOPERFUSION
    Charles Wood; Fiscal Year: 1999
    ..Improvement of our knowledge of the rnle of prostanoids in the control of fetal blood pressure is also quite important in light of the use of prostaglandin synthase inhibitors clinically for various reasons, including tocolysis. ..
  2. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
    ..Argon laser treatment to the peripheral iris and Nd:YAG laser treatment to the trabecular mesh-work will be performed in cats to determine whether they also result in reduction of IOP mediated by PGs...
  3. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1990
    ..Argon laser treatment to the peripheral iris and Nd:YAG laser treatment to the trabecular mesh-work will be performed in cats to determine whether they also result in reduction of IOP mediated by PGs...
  4. EICOSANOIDS IN GALLBLADDER PHYSIOLOGY AND DISEASE
    DONALD KAMINSKI; Fiscal Year: 1991
    ..In experimental models of cholecystitis, cyclooxygenase inhibitors decrease gallbladder inflammation...
  5. Aspects of Biotin Nutrition
    Donald M Mock; Fiscal Year: 2010
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo; In Specific Aim #2, we will test the hypothesis that ..
  6. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2009
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo; In Specific Aim #2, we will test the hypothesis that ..
  7. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2009
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo; In Specific Aim #2, we will test the hypothesis that ..
  8. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
    ..hydralazine and thiazides enhance vascular prostacyclin synthesis, which accounts for the ability of cyclooxygenase inhibitors to reduce the antihypertensive efficacy and 2) clinical studies on furosemide induced venodilation and ..
  9. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1990
    ..segmental distribution of PVR attendant to varying degrees of COI induced by three chemically dissimilar cyclooxygenase inhibitors (aspirin, meclofenamate and indomethacin)...
  10. CELLULAR MECHANISMS OF CHOLECYSTITIS AND COLITIS
    DONALD KAMINSKI; Fiscal Year: 1999
    ..Previous studies have demonstrated that cyclooxygenase inhibitors are specific drugs for the treatment of gallbladder disease...
  11. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy A Zimmerman; Fiscal Year: 2010
    ..could potentially be used independently or in combination with other antithrombotic therapies including cyclooxygenase inhibitors (aspirin), thienopyridines (clopidogrel), and anticoagulants (heparin, warfarin)...
  12. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy Zimmerman; Fiscal Year: 2009
    ..could potentially be used independently or in combination with other antithrombotic therapies including cyclooxygenase inhibitors (aspirin), thienopyridines (clopidogrel), and anticoagulants (heparin, warfarin)...
  13. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2003
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo...
  14. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2002
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo...
  15. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2004
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo...
  16. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2006
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo...
  17. Aspects of Biotin Nutrition
    Donald Mock; Fiscal Year: 2005
    ..of supplementation of arachidonic acid and prostaglandin and the amelioration blocking effects of cyclooxygenase inhibitors. Analogous studies will also be conducted in vivo...
  18. ALCOHOLIC EMBRYOPATHY & MATERNAL HYPERTENSION
    RUSSELL MANKES; Fiscal Year: 1992
    ..agents and to prostaglandin and thromboxane agonists; and to prostaglandin receptor blocking drugs and cyclooxygenase inhibitors. 5...
  19. ALCOHOLIC EMBRYOPATHY & MATERNAL HYPERTENSION
    RUSSELL MANKES; Fiscal Year: 1990
    ..agents and to prostaglandin and thromboxane agonists; and to prostaglandin receptor blocking drugs and cyclooxygenase inhibitors. 5...
  20. VANDERBILT CENTER FOR EDUCATION/RESEARCH ON THERAPEUTICS
    Wayne Ray; Fiscal Year: 2005
    ..The cohort will include 109,290 new NSAID/coxib users and will have a power (=.05, 1.-=.80) to detect protective rate-ratio of .74 for both H1 and H2. ..
  21. CONTROL AND ACTIONS OF RENAL CYCLIC GMP
    FREDERICK DERUBERTIS; Fiscal Year: 1980
    ..Studies are currently in progress exploring the role of calmodulin in Ca 2 ion dependent regulation of cGMP in kidney...
  22. ROLE OF CYTOKINES IN THYROXIN-STIMULATED BONE LOSS
    Paula Stern; Fiscal Year: 1992
    ..Since thyroid hormones stimulate prostaglandin production in some tissues, cyclooxygenase inhibitors will be used to assess the relationship of prostaglandin production to the secretion of the local ..
  23. Renal Processing of Albumin
    Oliver Smithies; Fiscal Year: 2009
    ..Our preliminary data show that in normal mice angiotensin converting enzyme and/or cyclooxygenase inhibitors in high dose cause temporary reversible albuminuria, exacerbated by a low salt diet...
  24. Renal Processing of Albumin
    Oliver Smithies; Fiscal Year: 2010
    ..Our preliminary data show that in normal mice angiotensin converting enzyme and/or cyclooxygenase inhibitors in high dose cause temporary reversible albuminuria, exacerbated by a low salt diet...
  25. DEATH AND SHOCK FROM ADRENAL INSUFFICIENCY
    DANIEL DARLINGTON; Fiscal Year: 1992
    ..Also, we will determine if prostaglandins or histamines are involved in the decay of arterial blood pressure and death following hemorrhage using cyclo- oxygenase inhibitors and H1 and H2 blockers...
  26. NEURAL MECHANISMS OF PAIN AND HYPERALGESIA
    Jon Levine; Fiscal Year: 1993
    ..of leukotrienes (LTs), a newly discovered class of AA metabolites whose synthesis is not blocked by cyclooxygenase inhibitors. We showed that leukotriene B4 (LTB4), a product of the 5-lipoxygenase pathway of AA metabolism, reduced ..
  27. NEURAL MECHANISMS OF PAIN AND HYPERALGESIA
    Jon Levine; Fiscal Year: 1992
    ..of leukotrienes (LTs), a newly discovered class of AA metabolites whose synthesis is not blocked by cyclooxygenase inhibitors. We showed that leukotriene B4 (LTB4), a product of the 5-lipoxygenase pathway of AA metabolism, reduced ..
  28. NEURAL MECHANISMS OF PAIN AND HYPERALGESIA
    Jon Levine; Fiscal Year: 1991
    ..of leukotrienes (LTs), a newly discovered class of AA metabolites whose synthesis is not blocked by cyclooxygenase inhibitors. We showed that leukotriene B4 (LTB4), a product of the 5-lipoxygenase pathway of AA metabolism, reduced ..
  29. NEURAL MECHANISMS OF PAIN AND HYPERALGESIA
    Jon Levine; Fiscal Year: 1990
    ..of leukotrienes (LTs), a newly discovered class of AA metabolites whose synthesis is not blocked by cyclooxygenase inhibitors. We showed that leukotriene B4 (LTB4), a product of the 5-lipoxygenase pathway of AA metabolism, reduced ..
  30. Eicosanoids and Diabetic Retinopathy
    Rose Gubitosi Klug; Fiscal Year: 2007
    ..The candidate's preliminary data suggest that both lipoxygenase and cyclooxygenase inhibitors can ameliorate the high glucose-induced cell death seen in cultured retinal endothelial cells...
  31. Eicosanoids and Diabetic Retinopathy
    Rose Gubitosi Klug; Fiscal Year: 2009
    ..The candidate's preliminary data suggest that both lipoxygenase and cyclooxygenase inhibitors can ameliorate the high glucose-induced cell death seen in cultured retinal endothelial cells...
  32. Eicosanoids and Diabetic Retinopathy
    Rose Gubitosi Klug; Fiscal Year: 2005
    ..The candidate's preliminary data suggest that both lipoxygenase and cyclooxygenase inhibitors can ameliorate the high glucose-induced cell death seen in cultured retinal endothelial cells...
  33. Eicosanoids and Diabetic Retinopathy
    Rose Gubitosi Klug; Fiscal Year: 2006
    ..The candidate's preliminary data suggest that both lipoxygenase and cyclooxygenase inhibitors can ameliorate the high glucose-induced cell death seen in cultured retinal endothelial cells...
  34. HUMORAL MEDIATORS OF PULMONARY INFLAMMATION
    James Ryan; Fiscal Year: 1980
    ..Should either the kallikrein-kinin system or substances influenced by putative cyclo-oxygenase inhibitors clearly modify the course of anaphylaxis, it may be possible to design means of ameliorating the disease. ..
  35. Use of Novel Cox-2 Inhibitors in Neurological Disorders
    STANLEY BELL; Fiscal Year: 2005
    ....
  36. Use of Novel Cox-2 Inhibitors in Neurological Disorders
    STANLEY BELL; Fiscal Year: 2006
    ....
  37. PROSTANOID BIOSYNTHESIS IN SYSTEMIC MASTOCYTOSIS
    John Oates; Fiscal Year: 2003
    ..Inhibition of PGD2 biosynthesis with nonselective cyclooxygenase inhibitors (the nonsteroidal anti- inflammatory drugs) has been employed in the treatment of this disorder, but ..
  38. PROSTANOID BIOSYNTHESIS IN SYSTEMIC MASTOCYTOSIS
    John Oates; Fiscal Year: 2001
    ..Inhibition of PGD2 biosynthesis with nonselective cyclooxygenase inhibitors (the nonsteroidal anti- inflammatory drugs) has been employed in the treatment of this disorder, but ..
  39. PHARMACOKINETICS OF ANTIATHEROGENIC DRUGS
    John Bailey; Fiscal Year: 1980
    ..We have shown that the protective effects of cyclooxygenase inhibitors can be duplicated in an experimental animal model...
  40. PROSTANOID BIOSYNTHESIS IN SYSTEMIC MASTOCYTOSIS
    John Oates; Fiscal Year: 2002
    ..Inhibition of PGD2 biosynthesis with nonselective cyclooxygenase inhibitors (the nonsteroidal anti- inflammatory drugs) has been employed in the treatment of this disorder, but ..
  41. EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGEN
    Robert Naclerio; Fiscal Year: 1990
    ..is the evaluation of existing therapies, including antihistamines, topical and systemic corticosteroids, cyclooxygenase inhibitors and immunotherapy, to determine their effect on the response to nasal challenge...
  42. EVALUATION OF THE NASAL LATE PHASE RESPONSE TO ANTIGEN
    Robert Naclerio; Fiscal Year: 1992
    ..is the evaluation of existing therapies, including antihistamines, topical and systemic corticosteroids, cyclooxygenase inhibitors and immunotherapy, to determine their effect on the response to nasal challenge...
  43. CORNEAL ARACHIDONIC ACID METABOLISM
    Alan Proia; Fiscal Year: 1990
    ..A final study will examine the influence of lipoxygenase inhibitors, cyclooxygenase inhibitors, and a dual cyclooxygenase-lipoxygenase inhibitor on corneal inflammation and vascularization following ..
  44. CARDIOPULMONARY EFFECTS OF IBUPROFEN IN HUMAN SEPSIS
    Gordon Bernard; Fiscal Year: 1990
    ..utilizing the sheep endotoxin model of ARDS as well as data from human pilot studies suggests that cyclooxygenase inhibitors (ibuprofen, in particular) would be useful in the prevention and reversal of many of the ..
  45. UAB CERTs of Musculoskeletal Disorders
    Kenneth Saag; Fiscal Year: 2005
    ....
  46. Clinical Pharmacology of Acetaminophen and Salicylate
    John Oates; Fiscal Year: 2001
    Description: (provided by applicant) In contrast to the cyclooxygenase inhibitors in the nonsteroidal anti-inflammatory class, acetaminophen exerts a more narrow spectrum of pharmacologic effects, acting primarily as an antipyretic and ..
  47. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2009
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  48. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2006
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  49. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2007
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  50. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2005
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..