Genomes and Genes
Summary: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Publications314 found, 100 shown here
- Oxidative stress, antioxidants and stress toleranceRon Mittler
Dept of Botany, Plant Sciences Institute, 353 Bessey Hall, Iowa State University, Ames, IA 50011, USA
Trends Plant Sci 7:405-10. 2002..ROIs) were considered to be toxic by-products of aerobic metabolism, which were disposed of using antioxidants. However, in recent years, it has become apparent that plants actively produce ROIs as signaling molecules to ..
- Free radicals, metals and antioxidants in oxidative stress-induced cancerM Valko
Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
Chem Biol Interact 160:1-40. 2006..of enzymatic (superoxide dismutase (Cu, Zn-SOD, Mn-SOD), catalase, glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, Vitamin E, carotenoids, thiol antioxidants (glutathione, thioredoxin and lipoic acid), flavonoids, ..
- Free radicals and antioxidants in normal physiological functions and human diseaseMarian Valko
Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
Int J Biochem Cell Biol 39:44-84. 2007..of free radical generation; (ii) damage to DNA, to proteins, and to lipids by free radicals; (iii) role of antioxidants (e.g...
- Increased oxidative stress in obesity and its impact on metabolic syndromeShigetada Furukawa
Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Clin Invest 114:1752-61. 2004....
- Oxidative stress and neurodegeneration: where are we now?Barry Halliwell
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J Neurochem 97:1634-58. 2006..After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases...
- Mitochondrial formation of reactive oxygen speciesJulio F Turrens
Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
J Physiol 552:335-44. 2003..We also discuss various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants...
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisGina M DeNicola
Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
Nature 475:106-9. 2011..Thus, the Nrf2 antioxidant and cellular detoxification program represents a previously unappreciated mediator of oncogenesis...
- Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)Scott M Lippman
Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
JAMA 301:39-51. 2009..Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer...
- Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force productionScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
Physiol Rev 88:1243-76. 2008..Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction...
- Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayThomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Annu Rev Pharmacol Toxicol 47:89-116. 2007..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses...
- Mitochondria, oxidative stress and cell deathMartin Ott
Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
Apoptosis 12:913-22. 2007..Conversely, mitochondrial antioxidant enzymes protect from apoptosis. Hence, there is accumulating evidence supporting a direct link between mitochondria, oxidative stress and cell death...
- Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysisGoran Bjelakovic
The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
JAMA 297:842-57. 2007..Antioxidant supplements are used for prevention of several diseases...
- Diabetes, oxidative stress, and antioxidants: a reviewA C Maritim
Moi University, College of Health Sciences, Eldoret, Kenya
J Biochem Mol Toxicol 17:24-38. 2003....
- Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)Eric A Klein
Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
JAMA 306:1549-56. 2011..Longer follow-up and more prostate cancer events provide further insight into the relationship of vitamin E and prostate cancer...
- Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetesJoseph L Evans
University of California at San Francisco, San Francisco, California 94143, USA
Endocr Rev 23:599-622. 2002..Studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetylcysteine suggest that new strategies may become available to ..
- Reactive oxygen species have a causal role in multiple forms of insulin resistanceNicholas Houstis
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
Nature 440:944-8. 2006..Together, our findings suggest that increased ROS levels are an important trigger for insulin resistance in numerous settings...
- Nrf2-Keap1 defines a physiologically important stress response mechanismHozumi Motohashi
Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
Trends Mol Med 10:549-57. 2004..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation...
- The chemistry behind antioxidant capacity assaysDejian Huang
Food Science and Technology Program, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
J Agric Food Chem 53:1841-56. 2005This review summarizes the multifaceted aspects of antioxidants and the basic kinetic models of inhibited autoxidation and analyzes the chemical principles of antioxidant capacity assays...
- Antioxidants prevent health-promoting effects of physical exercise in humansMichael Ristow
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
Proc Natl Acad Sci U S A 106:8665-70. 2009..However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown...
- The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressTruyen Nguyen
Schering Plough Research Institute, Summit, New Jersey 07901, USA
J Biol Chem 284:13291-5. 2009..In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway in neuroprotection will also be discussed...
- Reactive oxygen species, antioxidants, and the mammalian thioredoxin systemJ Nordberg
Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Free Radic Biol Med 31:1287-312. 2001..Dinitrohalobenzenes constitute a unique class of immunostimulatory TrxR inhibitors and we consider the immunomodulatory effects of dinitrohalobenzene compounds in view of their reactions with the Trx system...
- Mechanism of human SIRT1 activation by resveratrolMargie T Borra
Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Biol Chem 280:17187-95. 2005..We propose that binding of resveratrol to SIRT1 promotes a conformational change that better accommodates the attached coumarin group...
- Dietary polyphenols and the prevention of diseasesAugustin Scalbert
Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
Crit Rev Food Sci Nutr 45:287-306. 2005Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine...
- The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouseG P Lim
Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 21:8370-7. 2001..Microgliosis was also suppressed in neuronal layers but not adjacent to plaques. In view of its efficacy and apparent low toxicity, this Indian spice component shows promise for the prevention of Alzheimer's disease...
- Antioxidants, oxidative damage and oxygen deprivation stress: a reviewOlga Blokhina
Department of Biosciences, Division of Plant Physiology, Viikki Biocenter, FIN 00014 Helsinki University, Finland
Ann Bot 91:179-94. 2003..The formation of ROS is prevented by an antioxidant system: low molecular mass antioxidants (ascorbic acid, glutathione, tocopherols), enzymes regenerating the reduced forms of antioxidants, and ROS-..
- Free radicals and antioxidants - quo vadis?Barry Halliwell
Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597
Trends Pharmacol Sci 32:125-30. 2011The field of free radicals and antioxidants, or 'redox biology', is fundamental to aerobic life. Aerobes constantly make reactive species, but modulate their actions by synthesizing antioxidants...
- Oxidative stress in the pathogenesis of skin diseaseDavid R Bickers
Department of Dermatology, Columbia University Medical Center, New York, New York, USA
J Invest Dermatol 126:2565-75. 2006..These include non-enzymatic and enzymatic molecules that function as potent antioxidants or oxidant-degrading systems...
- Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulationMakoto Kobayashi
ERATO JST, Center for TARA and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
Antioxid Redox Signal 7:385-94. 2005..This review article recounts recent knowledge of the Nrf2-Keap1 system, focusing especially on the molecular mechanism of Nrf2 regulation...
- Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretationPat Monaghan
Division of Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G128QQ, UK
Ecol Lett 12:75-92. 2009..is currently used somewhat loosely by many ecologists, and the erroneous assumption often made that dietary antioxidants are necessarily the major line of defence against ROS-induced damage...
- Flavonoids as antioxidantsP G Pietta
Institute of Advanced Biomedical Technologies, National Council of Research Via F lli Cervi 93, 20090 Segrate Mi, Italy
J Nat Prod 63:1035-42. 2000..They act in plants as antioxidants, antimicrobials, photoreceptors, visual attractors, feeding repellants, and for light screening...
- Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancerYizhong Cai
Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
Life Sci 74:2157-84. 2004..Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents.
- Free radicals and antioxidants: updating a personal viewBarry Halliwell
Department of Biochemistry, National University of Singapore, Singapore
Nutr Rev 70:257-65. 2012..Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in ..
- Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatoryRong Hu
Department of Physiology, China Pharmaceutical University, Nanjing, China
Antioxid Redox Signal 13:1679-98. 2010..We will also discuss some of the potential caveats of Nrf2 in cancer treatment and future opportunity and challenges on regulation of Nrf2-mediated antioxidant and antiinflammatory signaling in the context of cancer prevention...
- Antioxidants: Molecules, medicines, and mythsJohn M C Gutteridge
Potters Bar, Hertfordshire, UK
Biochem Biophys Res Commun 393:561-4. 2010There is an industry-driven public obsession with antioxidants, which are equated to safe, health-giving molecules to be swallowed as mega-dose supplements or in fortified foods...
- Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core proteinMichiari Okuda
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0641, USA
Gastroenterology 122:366-75. 2002..Indirect evidence suggests that oxidative stress and mitochondrial injury play a role. The aim of this study was to determine if the HCV core protein itself alters mitochondrial function and contributes to oxidative stress...
- The Nrf2 system as a potential target for the development of indirect antioxidantsKyeong Ah Jung
College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongsangbuk do 712 749, Korea
Molecules 15:7266-91. 2010..In this review, we discuss the role of the Nrf2 system, with particular focus on Nrf2-controlled target genes and the potential pleiotropic effects of Nrf2 activation of indirect antioxidants.
- Flavonoids: a review of probable mechanisms of action and potential applicationsR J Nijveldt
Department of Surgery, Vrije Universiteit Medical Center, Amsterdam, Netherlands
Am J Clin Nutr 74:418-25. 2001..We review the different groups of known flavonoids, the probable mechanisms by which they act, and the potential clinical applications of these fascinating natural substances...
- Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery diseaseT Heitzer
Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
Circulation 104:2673-8. 2001..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
- Flavonoids: antioxidants or signalling molecules?Robert J Williams
Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
Free Radic Biol Med 36:838-49. 2004..an emerging view that flavonoids, and their in vivo metabolites, do not act as conventional hydrogen-donating antioxidants but may exert modulatory actions in cells through actions at protein kinase and lipid kinase signalling ..
- Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetesR Paul Robertson
Pacific Northwest Research Institute, Seattle, Washington 98122, USA
J Biol Chem 279:42351-4. 2004
- Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidantsM Aviram
The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
Free Radic Biol Med 26:892-904. 1999..b>Antioxidants such as the flavonoids glabridin or quercetin, when present during LDL oxidation in the presence of PON, ..
- Polyphenols and disease risk in epidemiologic studiesIlja C W Arts
RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
Am J Clin Nutr 81:317S-325S. 2005Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases...
- A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cationOzcan Erel
Clinical Biochemistry Department, Medical Faculty, Research Hospital, Harran University, Sanliurfa TR63200, Turkey
Clin Biochem 37:277-85. 2004..To develop a novel colorimetric and automated direct measurement method for total antioxidant capacity (TAC)...
- Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalingSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 38:1543-52. 2005..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come...
- Selenium: a double-edged sword for defense and offence in cancerJela Brozmanová
Laboratory of Molecular Genetics, Cancer Research Institute, Vlarska 7, 833 91, Bratislava, Slovak Republic
Arch Toxicol 84:919-38. 2010..Since Saccharomyces cerevisiae has proven a powerful tool for addressing some important questions regarding Se biology, a part of this review is devoted to this model system...
- NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotectorAlbena T Dinkova-Kostova
Biomedical Research Institute, University of Dundee, Dundee, Scotland, UK
Arch Biochem Biophys 501:116-23. 2010....
- New concepts in reactive oxygen species and cardiovascular reperfusion physiologyLance B Becker
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Cardiovasc Res 61:461-70. 2004..whole organ and animal models continue to report contradictory results on reperfusion injury and the role of antioxidants as a therapy...
- Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional studyDario Maggio
Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy
J Clin Endocrinol Metab 88:1523-7. 2003..between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty...
- Moderate exercise is an antioxidant: upregulation of antioxidant genes by trainingMari Carmen Gomez-Cabrera
Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez, 15, 46010 Valencia, Spain
Free Radic Biol Med 44:126-31. 2008..We have found that interfering with free radical metabolism with antioxidants may hamper useful adaptations to training.
- Regulation of antioxidant enzymes: a significant role for melatoninCarmen Rodriguez
Departamento de Morfologia y Biologia Celular, Facultad de Medicina, c Julian Claveria, Oviedo, Spain
J Pineal Res 36:1-9. 2004..We also analyze the possible mechanisms by which melatonin regulates these enzymes...
- Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysisJong Min Lee
School of Pharmacy, Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
J Biol Chem 278:12029-38. 2003....
- The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and mineralsSerge Hercberg
Institut National de la Sante et de la Recherche Medicale, Unité de Recherche Médicale INSERM Institut National de la Recherche Agronomique Conservatoire National des Ants et Métiers CNAM, Paris, France
Arch Intern Med 164:2335-42. 2004..We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population...
- Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatmentB Halliwell
Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
Drugs Aging 18:685-716. 2001..Hence, there are many attempts to develop antioxidants that can cross the blood-brain barrier and decrease oxidative damage...
- Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological modelLutz W D Weber
Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
Crit Rev Toxicol 33:105-36. 2003..Several of the above-mentioned toxication processes can be specifically interrupted with the use of antioxidants and mitogens, respectively, by restoring cellular methylation, or by preserving calcium sequestration...
- Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cellsKeisuke Ito
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
Nature 431:997-1002. 2004..These results show that the self-renewal capacity of HSCs depends on ATM-mediated inhibition of oxidative stress...
- Oxidative stress in prostate cancerLakshmipathi Khandrika
Signal Transduction and Molecular Urology Laboratory, Division of Urology, Department of Surgery, School of Medicine, University of Colorado at Denver and Health Sciences Center, 12700 E 19th Avenue, Aurora, CO 80045, USA
Cancer Lett 282:125-36. 2009..In this review we summarize the causes for increased ROS generation and its potential role in etiology and progression of prostate cancer...
- Antioxidant activity of plant extracts containing phenolic compoundsM P Kähkönen
Department of Applied Chemistry, Division of Food Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
J Agric Food Chem 47:3954-62. 1999..In addition, potato peel and beetroot peel extracts showed strong antioxidant effects. To utilize these significant sources of natural antioxidants, further characterization of the phenolic composition is needed.
- Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionMichael McMahon
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 278:21592-600. 2003..Within Nrf2, the N-terminal Neh2 domain is identified as the redox-sensitive degron. These data suggest that Keap1 negatively regulates Nrf2 by both enhancing its rate of proteasomal degradation and altering its subcellular distribution...
- Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveriesA Bowie
Department of Biochemistry, Trinity College, Dublin, Ireland
Biochem Pharmacol 59:13-23. 2000..peroxide is cell-specific and distinct from physiological activators such as IL-1 and TNF, while inhibition by antioxidants, also found to be cell- and stimulus-specific, can involve diverse and unexpected targets which may be distinct ..
- Antioxidants in health and diseaseI S Young
Department of Clinical Biochemistry, Institute of Clinical Science, Belfast, Northern Ireland, UK
J Clin Pathol 54:176-86. 2001..b>Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by ..
- Antioxidant therapy in human endocrine disordersSaeid Golbidi
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
Med Sci Monit 16:RA9-24. 2010..b>Antioxidants can delay or prevent oxidative stress and are widely used in the hope of maintaining health and preventing ..
- Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signallingLing Gao
Cardiovascular Division, School of Medicine, King s College London, London, UK
Cardiovasc Res 82:9-20. 2009..Given the largely negative outcome of antioxidant therapy in the treatment of diabetic complications, targeting the redox-sensitive transcription factor Nfr2 may provide an effective strategy to restore antioxidant defenses in diabetes...
- Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic propertiesG F Kelso
Departments of Chemistry and Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
J Biol Chem 276:4588-96. 2001..We have shown that selectively manipulating mitochondrial antioxidant status with targeted and recyclable antioxidants is a feasible approach to investigate the role of mitochondrial oxidative damage in apoptotic cell death...
- Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissuesQi Chen
Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:13604-9. 2005..These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H(2)O(2) may be beneficial...
- Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic lifeBarry Halliwell
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
Plant Physiol 141:312-22. 2006
- Evaluation of Launaea procumbens use in renal disorders: a rat modelRahmat Ali Khan
Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University Islamabad, 4400 Pakistan
J Ethnopharmacol 128:452-61. 2010..Launaea procumbens is used ethnopharmacologically in renal disorders. Its methanolic, chloroform, ethyl acetate, and n-hexane fractions were evaluated against CCl(4)-induced nephrotoxicity in rat...
- Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemiaZoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Am J Physiol Heart Circ Physiol 300:H1133-40. 2011..Our results suggest that adaptive activation of the Nrf2/ARE pathway confers endothelial protection under diabetic conditions...
- Antioxidant enzymes and human diseasesJ M Mates
Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Spain
Clin Biochem 32:595-603. 1999....
- Production of reactive oxygen species by mitochondria: central role of complex IIIQun Chen
Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 278:36027-31. 2003..In mitochondria, complex III is the principal site for ROS generation during the oxidation of complex I substrates, and rotenone protects by limiting electron flow into complex III...
- Metals, toxicity and oxidative stressM Valko
Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
Curr Med Chem 12:1161-208. 2005..b>Antioxidants (both enzymatic and non-enzymatic) provide protection against deleterious metal-mediated free radical attacks...
- Age-related macular degenerationHanna R Coleman
Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
Lancet 372:1835-45. 2008....
- Molecular mechanisms of Nrf2-mediated antioxidant responseWenge Li
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Mol Carcinog 48:91-104. 2009..Free floating Nrf2 protein functions as a redox-sensitive probe. Keap1 instead functions as a gate keeper to control the availability of Nrf2 probes and thus regulates the overall sensitivity of the redox signaling...
- The antioxidants and pro-antioxidants network: an overviewSilvia Vertuani
Department of Pharmaceutical Science, University of Ferrara, Ferrara, Italy
Curr Pharm Des 10:1677-94. 2004..Levels of these species are controlled by the antioxidant defence system, which is composed by antioxidants and pro-antioxidants. Several components of this system are micronutrients (e.g...
- Antioxidants in photosynthesis and human nutritionBarbara Demmig-Adams
Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder, CO 80309 0334, USA
Science 298:2149-53. 2002..The pathways that synthesize these compounds are becoming amenable to genetic manipulation, which may yield benefits as widespread as improved plant stress tolerance and improved human physical and mental health...
- Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damageN Ercal
University of Missouri Rolla, Department of Chemistry, 65409 0010, USA
Curr Top Med Chem 1:529-39. 2001..redox cycling whereas redox-inactive metals, such as lead, cadmium, mercury and others deplete cells' major antioxidants, particularly thiol-containing antioxidants and enzymes...
- Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?Barry Halliwell
Department of Biochemistry, National University of Singapore, University Hall, Lee Kong Chian Wing, UHL 05 02G, 21 Lower Kent Ridge Road, Singapore 119077, Singapore
Arch Biochem Biophys 476:107-12. 2008..Many studies of the biological effects of polyphenols in cell culture have been affected by their ability to oxidise in culture media, and awareness of this problem can avoid erroneous claims...
- Biological activities of sulfated polysaccharides from tropical seaweedsL S Costa
UFRN, Laboratório de Biotecnologia de Polímeros Naturais Biopol, Centro de Biociencias, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Av Sen Salgado Filho, 3000, 59072970 Natal, Rio Grande do Norte, Brazil
Biomed Pharmacother 64:21-8. 2010....
- Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performanceMari Carmen Gomez-Cabrera
Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
Am J Clin Nutr 87:142-9. 2008..There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation...
- Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadowsDomenico Pratico
Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA 19140, USA
Ann N Y Acad Sci 1147:70-8. 2008..This article will review both promises and caveats of the available data and propose future directions to be taken for addressing them...
- Vitamin E, antioxidant and nothing moreMaret G Traber
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Free Radic Biol Med 43:4-15. 2007..it seems unlikely that these pathways are specifically under the control of alpha-tocopherol given that various antioxidants other than alpha-tocopherol and various oxidative stressors can manipulate their responses...
- Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?Silvina B Lotito
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
Free Radic Biol Med 41:1727-46. 2006..These observations led to the hypothesis that dietary flavonoids play a significant role as antioxidants in vivo, thereby reducing chronic disease risk...
- Method for the measurement of antioxidant activity in human fluidsD Koracevic
Institute of Biochemistry, Medical Faculty, University Clinical Center, Nis, Yugoslavia
J Clin Pathol 54:356-61. 2001..To develop a new, simple, and cheap method for estimating antioxidant activity in human fluids...
- Beneficial effects of green tea--a reviewCarmen Cabrera
Departamento de Nutricion y Bromatologia, Facultad de Farmacia, Campus Universitario de Granada, Granada, Spain
J Am Coll Nutr 25:79-99. 2006..Catechins are in vitro and in vivo strong antioxidants. In addition, its content of certain minerals and vitamins increases the antioxidant potential of this type of ..
- Oxidant and antioxidant balance in the airways and airway diseasesIrfan Rahman
Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
Eur J Pharmacol 533:222-39. 2006..The lungs are therefore endowed with an armamentarium of a battery of endogenous agents called antioxidants. The antioxidant species help the lungs ward off the deleterious consequences of a wide variety of oxidants/..
- Function of marine carotenoidsKazuo Miyashita
Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Japan
Forum Nutr 61:136-46. 2009..The key structure of carotenoids for the expression of antiobesity effect was suggested to be carotenoid end of the polyene chromophore containing an allenic bond and two hydroxyl groups...
- Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cellsAruna Kode
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 294:L478-88. 2008..These data may have implications in dietary modulation of antioxidants in treatment of chronic obstructive pulmonary disease.
- Flavonoid antioxidantsC Rice-Evans
Antioxidant Research Group, Wolfson Centre for Age Related Diseases, Guy s, King s and St Thomas School of Biomedical Sciences, Hodgkin Building, Guy s Campus, London, SE1 9RT, UK
Curr Med Chem 8:797-807. 2001In order to ascertain the role of dietary flavonoids as antioxidants in vivo it is necessary to understand the chemical nature of the absorbed forms in the circulation in vivo and how the multiplicity of research findings in vitro reflect ..
- Reactive oxygen species in mitochondria-mediated cell deathSten Orrenius
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Drug Metab Rev 39:443-55. 2007..Taken together, these findings have placed the mitochondria in the focus of current cell death research...
- Preliminary phytochemical screening and in vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DCOlayinka A Aiyegoro
Applied and Environmental Microbiology Research Group AEMREG, Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa
BMC Complement Altern Med 10:21. 2010..A lot of researches are going on worldwide directed towards finding natural antioxidants of plants origins...
- Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trialHoward D Sesso
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
JAMA 300:2123-33. 2008..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
- Nrf2 signaling in coordinated activation of antioxidant gene expressionAnil K Jaiswal
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Free Radic Biol Med 36:1199-207. 2004..The future studies should also reveal a complete mechanism of signal transduction from antioxidants and xenobiotics to the transcription factors, such as Nrf2, that bind to ARE.
- Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathwayJohn D Hayes
Biomedical Research Institute, Ninewells Hospital, University of Dundee, Scotland, United Kingdom
Antioxid Redox Signal 13:1713-48. 2010....
- Oxidative stress markers in aqueous humor of glaucoma patientsSandra M Ferreira
Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologica, CONICET, Buenos Aires, Argentina
Am J Ophthalmol 137:62-9. 2004..For this purpose the authors measured the total reactive antioxidant potential (TRAP) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase...
- Neurodegenerative diseases and oxidative stressKevin J Barnham
Department of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Victoria 3010, Australia
Nat Rev Drug Discov 3:205-14. 2004..However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies...
- Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stressAndy Y Shih
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
J Neurosci 23:3394-406. 2003..Neuroprotection was not limited to overexpression of Nrf2, because activation of endogenous glial Nrf2 by the small molecule ARE inducer, tert-butylhydroquinone, also protected against oxidative glutamate toxicity...
- Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cellsJudith Haendeler
Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
Circ Res 94:768-75. 2004..1 micromol/L), had also effects similar to those of N-acetylcysteine. We conclude that both antioxidants and statins can delay the onset of replicative senescence by counteracting the increased ROS production linked ..
- Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatmentD R Evans
Department of Psychiatry and Health Behavior, Medical College of Georgia, GA, USA
Prostaglandins Leukot Essent Fatty Acids 69:393-9. 2003..These data also support the augmentation of antipsychotic treatment by supplementation with a combination of antioxidants and omega-3 fatty acids.
- Oxidative stress in psychiatric disorders: evidence base and therapeutic implicationsFelicity Ng
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Vic, Australia
Int J Neuropsychopharmacol 11:851-76. 2008..of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by ..
- Fucoidan protects against dopaminergic neuron death in vivo and in vitroDingzhen Luo
Key Laboratory of Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, PR China
Eur J Pharmacol 617:33-40. 2009..Taken together, these findings suggest that fucoidan has protective effect in MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative activity...
- Antioxidant response to oxidative stress induced by exhaustive exerciseAntoni Aguilo
Laboratori de Ciències de l Activitat Física and Department de Biologia Fonamental i Ciències de la Salut, Edifici Guillem Colom, Facultat de Ciencies, Universitat de les Illes Balears, Palma de Mallorca, Balears, Spain
Physiol Behav 84:1-7. 2005..A specific utilisation of alpha-tocopherol against oxidative stress during recovery was evidenced...
- Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's diseaseR Soto-Otero
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Santiago de Compostela, Spain
J Neurochem 74:1605-12. 2000..In this study we examine the effects of the antioxidants ascorbic acid (AA), glutathione (GSH), cysteine (CySH), and N-acetyl-CySH (NAC) on the autoxidation and ..
- DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUESYOGESH AWASTHI; Fiscal Year: 1993..system, they will establish the optimal conditions of induction of GSH, GST and GSH-Px by BHT and other dietary antioxidants and investigate the effects of antioxidants on individual GST isoenzymes and all the three forms of GSH-Px ..
- The Role of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal DysUla V Jurkunas; Fiscal Year: 2010..Our preliminary studies have identified a decrease in the antioxidant response element (ARE)-driven antioxidants, overexpression of extracellular and stress-related proteins, and an increase in the levels of oxidized ..
- Treatment of SLE with N-acetylcysteineAndras Perl; Fiscal Year: 2010..GSH is also depleted in lymphocytes of lupus-prone mice and NAC and other antioxidants reduce autoantibody production, prevent the development of glomerulonephritis, and prolong the survival of ..
- PEDIATRIC NEPHROLOGY TRAINING GRANTHarry Koo; Fiscal Year: 2003..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
- Role of Glutathione S-Transferase P in Heart FailureSumanth D Prabhu; Fiscal Year: 2010Although oxidative stress is a hallmark of heart failure (HF), clinical trials with antioxidants targeting first generation reactive oxygen species (ROS) such as O2/ and H2O2 have not yielded compelling benefits...
- Impact of obesity on airway responses to air pollutionStephanie A Shore; Fiscal Year: 2010..To address this hypothesis, we will measure lipid peroxidation and protein carbonylation products as well as antioxidants in the lungs and blood after room air exposure or at various times after acute O3 exposure...
- Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth NanoparticlesJAMES FRANCIS MCGINNIS; Fiscal Year: 2010..This is "oxidative stress" as a result of a chronic or acute rise in Reactive Oxygen Species (ROS). Antioxidants and over-expression of antioxidant enzymes have been shown to inhibit the progression of many retinal diseases...
- DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUESYOGESH AWASTHI; Fiscal Year: 1992..system, they will establish the optimal conditions of induction of GSH, GST and GSH-Px by BHT and other dietary antioxidants and investigate the effects of antioxidants on individual GST isoenzymes and all the three forms of GSH-Px ..
- Mechanisms and Prevention of Etoposide-Induced LeukemiaJack Yalowich; Fiscal Year: 2009..It is also posited that nutritional antioxidants such as vitamin C and vitamin E homologs will prevent VP-16-induced AML by reducing or preventing production of ..
- HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and AntioxidantsMarianna Baum; Fiscal Year: 2007..of hepatic damage leading to fibrosis in hepatitis C and is accompanied by decreased plasma micronutrient antioxidants. While many studies confirm the presence of elevated oxidative stress in HIV and in HCV mono-infections, no ..
- Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth NanoparticlesJames McGinnis; Fiscal Year: 2009..This is "oxidative stress" as a result of a chronic or acute rise in Reactive Oxygen Species (ROS). Antioxidants and over-expression of antioxidant enzymes have been shown to inhibit the progression of many retinal diseases...
- HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and AntioxidantsMarianna K Baum; Fiscal Year: 2010..of hepatic damage leading to fibrosis in hepatitis C and is accompanied by decreased plasma micronutrient antioxidants. While many studies confirm the presence of elevated oxidative stress in HIV and in HCV mono-infections, no ..
- Influence of Dietary Flavonoids on the Expression of At*Carl Keen; Fiscal Year: 2002..Vitamins and minerals contribute to the oxidative defense system because: (1) they are antioxidants (vitamins E, C and B-carotene); (2) they are essential for the function of enzyme antioxidants (Zn, Cu, Fe, Mn, ..
- TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGEArlan Richardson; Fiscal Year: 2001..oxidative stress hypothesis of aging using transgenic mouse models in which the balance between prooxidants and antioxidants is altered so that the steady state accumulation of oxidative damage is accelerated...
- Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective AnalysisA Heather Eliassen; Fiscal Year: 2010..we propose several studies to substantially improve our understanding of the role of oxidative stress and antioxidants in breast carcinogenesis...
- Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective AnalysisA Heather Eliassen; Fiscal Year: 2009..we propose several studies to substantially improve our understanding of the role of oxidative stress and antioxidants in breast carcinogenesis...
- Peroxiredoxin 6 and CataractogenesisDHIRENDRA SINGH; Fiscal Year: 2009..Age-Related Cataract, and suggests that aged lens cells are prone to this damage due to reduced expression of antioxidants. Because ocular lens is constantly exposed to environmental stress, it continuously generates reactive oxygen ..
- BIOLOGIC ACTIVITY OF BETA-CAROTENE METABOLITESRobert Russell; Fiscal Year: 2005..results in increased lung cell oxidative stress, thereby causing decreased tissue levels of other important antioxidants, such as ascorbate and alpha-tocopherol, which have a stabilizing effect on unoxidized beta-carotene...
- Cardiovascular Effects of Scutellaria baicelensisChun Su Yuan; Fiscal Year: 2002..nontraditional antioxidants may play in its acute treatment...
- Mechanisms of PCP genotoxicity & antioxidant modulationBENZHAN ZHU; Fiscal Year: 2002..through a novel, metal-independent mechanism (the so-called organic Fenton reaction); and that dietary antioxidants markedly inhibit -OH production from PCP metabolites...
- RICKETTSIA RICKETTSII IN HUMAN ENDOTHELIAL CELLSDavid Silverman; Fiscal Year: 2002..With an interest in abrogating endothelial cell injury, they have incorporated antioxidants into infected cell culture systems...