antioxidants

Summary

Summary: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

Top Publications

  1. ncbi Oxidative stress, antioxidants and stress tolerance
    Ron Mittler
    Dept of Botany, Plant Sciences Institute, 353 Bessey Hall, Iowa State University, Ames, IA 50011, USA
    Trends Plant Sci 7:405-10. 2002
  2. ncbi Free radicals, metals and antioxidants in oxidative stress-induced cancer
    M Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Chem Biol Interact 160:1-40. 2006
  3. ncbi Free radicals and antioxidants in normal physiological functions and human disease
    Marian Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Int J Biochem Cell Biol 39:44-84. 2007
  4. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
  5. ncbi Oxidative stress and neurodegeneration: where are we now?
    Barry Halliwell
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurochem 97:1634-58. 2006
  6. pmc Mitochondrial formation of reactive oxygen species
    Julio F Turrens
    Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
    J Physiol 552:335-44. 2003
  7. pmc Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    Gina M DeNicola
    Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
    Nature 475:106-9. 2011
  8. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
  9. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
  10. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007

Detail Information

Publications314 found, 100 shown here

  1. ncbi Oxidative stress, antioxidants and stress tolerance
    Ron Mittler
    Dept of Botany, Plant Sciences Institute, 353 Bessey Hall, Iowa State University, Ames, IA 50011, USA
    Trends Plant Sci 7:405-10. 2002
    ..ROIs) were considered to be toxic by-products of aerobic metabolism, which were disposed of using antioxidants. However, in recent years, it has become apparent that plants actively produce ROIs as signaling molecules to ..
  2. ncbi Free radicals, metals and antioxidants in oxidative stress-induced cancer
    M Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Chem Biol Interact 160:1-40. 2006
    ..of enzymatic (superoxide dismutase (Cu, Zn-SOD, Mn-SOD), catalase, glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, Vitamin E, carotenoids, thiol antioxidants (glutathione, thioredoxin and lipoic acid), flavonoids, ..
  3. ncbi Free radicals and antioxidants in normal physiological functions and human disease
    Marian Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Int J Biochem Cell Biol 39:44-84. 2007
    ..of free radical generation; (ii) damage to DNA, to proteins, and to lipids by free radicals; (iii) role of antioxidants (e.g...
  4. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
    ....
  5. ncbi Oxidative stress and neurodegeneration: where are we now?
    Barry Halliwell
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurochem 97:1634-58. 2006
    ..After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases...
  6. pmc Mitochondrial formation of reactive oxygen species
    Julio F Turrens
    Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
    J Physiol 552:335-44. 2003
    ..We also discuss various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants...
  7. pmc Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    Gina M DeNicola
    Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
    Nature 475:106-9. 2011
    ..Thus, the Nrf2 antioxidant and cellular detoxification program represents a previously unappreciated mediator of oncogenesis...
  8. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
    ..Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer...
  9. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
    ..Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction...
  10. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007
    ..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses...
  11. ncbi Mitochondria, oxidative stress and cell death
    Martin Ott
    Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Apoptosis 12:913-22. 2007
    ..Conversely, mitochondrial antioxidant enzymes protect from apoptosis. Hence, there is accumulating evidence supporting a direct link between mitochondria, oxidative stress and cell death...
  12. ncbi Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 297:842-57. 2007
    ..Antioxidant supplements are used for prevention of several diseases...
  13. ncbi Diabetes, oxidative stress, and antioxidants: a review
    A C Maritim
    Moi University, College of Health Sciences, Eldoret, Kenya
    J Biochem Mol Toxicol 17:24-38. 2003
    ....
  14. doi Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
    ..Longer follow-up and more prostate cancer events provide further insight into the relationship of vitamin E and prostate cancer...
  15. ncbi Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Joseph L Evans
    University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Rev 23:599-622. 2002
    ..Studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetylcysteine suggest that new strategies may become available to ..
  16. ncbi Reactive oxygen species have a causal role in multiple forms of insulin resistance
    Nicholas Houstis
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 440:944-8. 2006
    ..Together, our findings suggest that increased ROS levels are an important trigger for insulin resistance in numerous settings...
  17. ncbi Nrf2-Keap1 defines a physiologically important stress response mechanism
    Hozumi Motohashi
    Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
    Trends Mol Med 10:549-57. 2004
    ..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation...
  18. ncbi The chemistry behind antioxidant capacity assays
    Dejian Huang
    Food Science and Technology Program, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
    J Agric Food Chem 53:1841-56. 2005
    This review summarizes the multifaceted aspects of antioxidants and the basic kinetic models of inhibited autoxidation and analyzes the chemical principles of antioxidant capacity assays...
  19. pmc Antioxidants prevent health-promoting effects of physical exercise in humans
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Proc Natl Acad Sci U S A 106:8665-70. 2009
    ..However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown...
  20. pmc The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    Truyen Nguyen
    Schering Plough Research Institute, Summit, New Jersey 07901, USA
    J Biol Chem 284:13291-5. 2009
    ..In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway in neuroprotection will also be discussed...
  21. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
    ..Dinitrohalobenzenes constitute a unique class of immunostimulatory TrxR inhibitors and we consider the immunomodulatory effects of dinitrohalobenzene compounds in view of their reactions with the Trx system...
  22. ncbi Mechanism of human SIRT1 activation by resveratrol
    Margie T Borra
    Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 280:17187-95. 2005
    ..We propose that binding of resveratrol to SIRT1 promotes a conformational change that better accommodates the attached coumarin group...
  23. ncbi Dietary polyphenols and the prevention of diseases
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
    Crit Rev Food Sci Nutr 45:287-306. 2005
    Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine...
  24. ncbi The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    G P Lim
    Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 21:8370-7. 2001
    ..Microgliosis was also suppressed in neuronal layers but not adjacent to plaques. In view of its efficacy and apparent low toxicity, this Indian spice component shows promise for the prevention of Alzheimer's disease...
  25. ncbi Antioxidants, oxidative damage and oxygen deprivation stress: a review
    Olga Blokhina
    Department of Biosciences, Division of Plant Physiology, Viikki Biocenter, FIN 00014 Helsinki University, Finland
    Ann Bot 91:179-94. 2003
    ..The formation of ROS is prevented by an antioxidant system: low molecular mass antioxidants (ascorbic acid, glutathione, tocopherols), enzymes regenerating the reduced forms of antioxidants, and ROS-..
  26. doi Free radicals and antioxidants - quo vadis?
    Barry Halliwell
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597
    Trends Pharmacol Sci 32:125-30. 2011
    The field of free radicals and antioxidants, or 'redox biology', is fundamental to aerobic life. Aerobes constantly make reactive species, but modulate their actions by synthesizing antioxidants...
  27. ncbi Oxidative stress in the pathogenesis of skin disease
    David R Bickers
    Department of Dermatology, Columbia University Medical Center, New York, New York, USA
    J Invest Dermatol 126:2565-75. 2006
    ..These include non-enzymatic and enzymatic molecules that function as potent antioxidants or oxidant-degrading systems...
  28. ncbi Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
    Makoto Kobayashi
    ERATO JST, Center for TARA and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    Antioxid Redox Signal 7:385-94. 2005
    ..This review article recounts recent knowledge of the Nrf2-Keap1 system, focusing especially on the molecular mechanism of Nrf2 regulation...
  29. doi Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation
    Pat Monaghan
    Division of Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G128QQ, UK
    Ecol Lett 12:75-92. 2009
    ..is currently used somewhat loosely by many ecologists, and the erroneous assumption often made that dietary antioxidants are necessarily the major line of defence against ROS-induced damage...
  30. ncbi Flavonoids as antioxidants
    P G Pietta
    Institute of Advanced Biomedical Technologies, National Council of Research Via F lli Cervi 93, 20090 Segrate Mi, Italy
    J Nat Prod 63:1035-42. 2000
    ..They act in plants as antioxidants, antimicrobials, photoreceptors, visual attractors, feeding repellants, and for light screening...
  31. ncbi Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer
    Yizhong Cai
    Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    Life Sci 74:2157-84. 2004
    ..Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents.
  32. doi Free radicals and antioxidants: updating a personal view
    Barry Halliwell
    Department of Biochemistry, National University of Singapore, Singapore
    Nutr Rev 70:257-65. 2012
    ..Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in ..
  33. pmc Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory
    Rong Hu
    Department of Physiology, China Pharmaceutical University, Nanjing, China
    Antioxid Redox Signal 13:1679-98. 2010
    ..We will also discuss some of the potential caveats of Nrf2 in cancer treatment and future opportunity and challenges on regulation of Nrf2-mediated antioxidant and antiinflammatory signaling in the context of cancer prevention...
  34. doi Antioxidants: Molecules, medicines, and myths
    John M C Gutteridge
    Potters Bar, Hertfordshire, UK
    Biochem Biophys Res Commun 393:561-4. 2010
    There is an industry-driven public obsession with antioxidants, which are equated to safe, health-giving molecules to be swallowed as mega-dose supplements or in fortified foods...
  35. ncbi Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    Michiari Okuda
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0641, USA
    Gastroenterology 122:366-75. 2002
    ..Indirect evidence suggests that oxidative stress and mitochondrial injury play a role. The aim of this study was to determine if the HCV core protein itself alters mitochondrial function and contributes to oxidative stress...
  36. doi The Nrf2 system as a potential target for the development of indirect antioxidants
    Kyeong Ah Jung
    College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongsangbuk do 712 749, Korea
    Molecules 15:7266-91. 2010
    ..In this review, we discuss the role of the Nrf2 system, with particular focus on Nrf2-controlled target genes and the potential pleiotropic effects of Nrf2 activation of indirect antioxidants.
  37. ncbi Flavonoids: a review of probable mechanisms of action and potential applications
    R J Nijveldt
    Department of Surgery, Vrije Universiteit Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 74:418-25. 2001
    ..We review the different groups of known flavonoids, the probable mechanisms by which they act, and the potential clinical applications of these fascinating natural substances...
  38. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  39. ncbi Flavonoids: antioxidants or signalling molecules?
    Robert J Williams
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
    Free Radic Biol Med 36:838-49. 2004
    ..an emerging view that flavonoids, and their in vivo metabolites, do not act as conventional hydrogen-donating antioxidants but may exert modulatory actions in cells through actions at protein kinase and lipid kinase signalling ..
  40. ncbi Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 279:42351-4. 2004
  41. ncbi Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 26:892-904. 1999
    ..b>Antioxidants such as the flavonoids glabridin or quercetin, when present during LDL oxidation in the presence of PON, ..
  42. ncbi Polyphenols and disease risk in epidemiologic studies
    Ilja C W Arts
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Am J Clin Nutr 81:317S-325S. 2005
    Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases...
  43. ncbi A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation
    Ozcan Erel
    Clinical Biochemistry Department, Medical Faculty, Research Hospital, Harran University, Sanliurfa TR63200, Turkey
    Clin Biochem 37:277-85. 2004
    ..To develop a novel colorimetric and automated direct measurement method for total antioxidant capacity (TAC)...
  44. ncbi Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 38:1543-52. 2005
    ..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come...
  45. doi Selenium: a double-edged sword for defense and offence in cancer
    Jela Brozmanová
    Laboratory of Molecular Genetics, Cancer Research Institute, Vlarska 7, 833 91, Bratislava, Slovak Republic
    Arch Toxicol 84:919-38. 2010
    ..Since Saccharomyces cerevisiae has proven a powerful tool for addressing some important questions regarding Se biology, a part of this review is devoted to this model system...
  46. pmc NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
    Albena T Dinkova-Kostova
    Biomedical Research Institute, University of Dundee, Dundee, Scotland, UK
    Arch Biochem Biophys 501:116-23. 2010
    ....
  47. ncbi New concepts in reactive oxygen species and cardiovascular reperfusion physiology
    Lance B Becker
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cardiovasc Res 61:461-70. 2004
    ..whole organ and animal models continue to report contradictory results on reperfusion injury and the role of antioxidants as a therapy...
  48. ncbi Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study
    Dario Maggio
    Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy
    J Clin Endocrinol Metab 88:1523-7. 2003
    ..between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty...
  49. doi Moderate exercise is an antioxidant: upregulation of antioxidant genes by training
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez, 15, 46010 Valencia, Spain
    Free Radic Biol Med 44:126-31. 2008
    ..We have found that interfering with free radical metabolism with antioxidants may hamper useful adaptations to training.
  50. ncbi Regulation of antioxidant enzymes: a significant role for melatonin
    Carmen Rodriguez
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, c Julian Claveria, Oviedo, Spain
    J Pineal Res 36:1-9. 2004
    ..We also analyze the possible mechanisms by which melatonin regulates these enzymes...
  51. ncbi Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    Jong Min Lee
    School of Pharmacy, Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 278:12029-38. 2003
    ....
  52. ncbi The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
    Serge Hercberg
    Institut National de la Sante et de la Recherche Medicale, Unité de Recherche Médicale INSERM Institut National de la Recherche Agronomique Conservatoire National des Ants et Métiers CNAM, Paris, France
    Arch Intern Med 164:2335-42. 2004
    ..We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population...
  53. ncbi Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment
    B Halliwell
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
    Drugs Aging 18:685-716. 2001
    ..Hence, there are many attempts to develop antioxidants that can cross the blood-brain barrier and decrease oxidative damage...
  54. ncbi Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    Lutz W D Weber
    Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
    Crit Rev Toxicol 33:105-36. 2003
    ..Several of the above-mentioned toxication processes can be specifically interrupted with the use of antioxidants and mitogens, respectively, by restoring cellular methylation, or by preserving calcium sequestration...
  55. ncbi Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 431:997-1002. 2004
    ..These results show that the self-renewal capacity of HSCs depends on ATM-mediated inhibition of oxidative stress...
  56. pmc Oxidative stress in prostate cancer
    Lakshmipathi Khandrika
    Signal Transduction and Molecular Urology Laboratory, Division of Urology, Department of Surgery, School of Medicine, University of Colorado at Denver and Health Sciences Center, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Cancer Lett 282:125-36. 2009
    ..In this review we summarize the causes for increased ROS generation and its potential role in etiology and progression of prostate cancer...
  57. ncbi Antioxidant activity of plant extracts containing phenolic compounds
    M P Kähkönen
    Department of Applied Chemistry, Division of Food Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    J Agric Food Chem 47:3954-62. 1999
    ..In addition, potato peel and beetroot peel extracts showed strong antioxidant effects. To utilize these significant sources of natural antioxidants, further characterization of the phenolic composition is needed.
  58. ncbi Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 278:21592-600. 2003
    ..Within Nrf2, the N-terminal Neh2 domain is identified as the redox-sensitive degron. These data suggest that Keap1 negatively regulates Nrf2 by both enhancing its rate of proteasomal degradation and altering its subcellular distribution...
  59. ncbi Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries
    A Bowie
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Biochem Pharmacol 59:13-23. 2000
    ..peroxide is cell-specific and distinct from physiological activators such as IL-1 and TNF, while inhibition by antioxidants, also found to be cell- and stimulus-specific, can involve diverse and unexpected targets which may be distinct ..
  60. pmc Antioxidants in health and disease
    I S Young
    Department of Clinical Biochemistry, Institute of Clinical Science, Belfast, Northern Ireland, UK
    J Clin Pathol 54:176-86. 2001
    ..b>Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by ..
  61. ncbi Antioxidant therapy in human endocrine disorders
    Saeid Golbidi
    Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Med Sci Monit 16:RA9-24. 2010
    ..b>Antioxidants can delay or prevent oxidative stress and are widely used in the hope of maintaining health and preventing ..
  62. doi Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling
    Ling Gao
    Cardiovascular Division, School of Medicine, King s College London, London, UK
    Cardiovasc Res 82:9-20. 2009
    ..Given the largely negative outcome of antioxidant therapy in the treatment of diabetic complications, targeting the redox-sensitive transcription factor Nfr2 may provide an effective strategy to restore antioxidant defenses in diabetes...
  63. ncbi Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
    G F Kelso
    Departments of Chemistry and Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
    J Biol Chem 276:4588-96. 2001
    ..We have shown that selectively manipulating mitochondrial antioxidant status with targeted and recyclable antioxidants is a feasible approach to investigate the role of mitochondrial oxidative damage in apoptotic cell death...
  64. pmc Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
    Qi Chen
    Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13604-9. 2005
    ..These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H(2)O(2) may be beneficial...
  65. pmc Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life
    Barry Halliwell
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Plant Physiol 141:312-22. 2006
  66. doi Evaluation of Launaea procumbens use in renal disorders: a rat model
    Rahmat Ali Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University Islamabad, 4400 Pakistan
    J Ethnopharmacol 128:452-61. 2010
    ..Launaea procumbens is used ethnopharmacologically in renal disorders. Its methanolic, chloroform, ethyl acetate, and n-hexane fractions were evaluated against CCl(4)-induced nephrotoxicity in rat...
  67. pmc Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Am J Physiol Heart Circ Physiol 300:H1133-40. 2011
    ..Our results suggest that adaptive activation of the Nrf2/ARE pathway confers endothelial protection under diabetic conditions...
  68. ncbi Antioxidant enzymes and human diseases
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Spain
    Clin Biochem 32:595-603. 1999
    ....
  69. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
    ..In mitochondria, complex III is the principal site for ROS generation during the oxidation of complex I substrates, and rotenone protects by limiting electron flow into complex III...
  70. ncbi Metals, toxicity and oxidative stress
    M Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Curr Med Chem 12:1161-208. 2005
    ..b>Antioxidants (both enzymatic and non-enzymatic) provide protection against deleterious metal-mediated free radical attacks...
  71. pmc Age-related macular degeneration
    Hanna R Coleman
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Lancet 372:1835-45. 2008
    ....
  72. pmc Molecular mechanisms of Nrf2-mediated antioxidant response
    Wenge Li
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Carcinog 48:91-104. 2009
    ..Free floating Nrf2 protein functions as a redox-sensitive probe. Keap1 instead functions as a gate keeper to control the availability of Nrf2 probes and thus regulates the overall sensitivity of the redox signaling...
  73. ncbi The antioxidants and pro-antioxidants network: an overview
    Silvia Vertuani
    Department of Pharmaceutical Science, University of Ferrara, Ferrara, Italy
    Curr Pharm Des 10:1677-94. 2004
    ..Levels of these species are controlled by the antioxidant defence system, which is composed by antioxidants and pro-antioxidants. Several components of this system are micronutrients (e.g...
  74. ncbi Antioxidants in photosynthesis and human nutrition
    Barbara Demmig-Adams
    Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder, CO 80309 0334, USA
    Science 298:2149-53. 2002
    ..The pathways that synthesize these compounds are becoming amenable to genetic manipulation, which may yield benefits as widespread as improved plant stress tolerance and improved human physical and mental health...
  75. ncbi Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
    N Ercal
    University of Missouri Rolla, Department of Chemistry, 65409 0010, USA
    Curr Top Med Chem 1:529-39. 2001
    ..redox cycling whereas redox-inactive metals, such as lead, cadmium, mercury and others deplete cells' major antioxidants, particularly thiol-containing antioxidants and enzymes...
  76. doi Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?
    Barry Halliwell
    Department of Biochemistry, National University of Singapore, University Hall, Lee Kong Chian Wing, UHL 05 02G, 21 Lower Kent Ridge Road, Singapore 119077, Singapore
    Arch Biochem Biophys 476:107-12. 2008
    ..Many studies of the biological effects of polyphenols in cell culture have been affected by their ability to oxidise in culture media, and awareness of this problem can avoid erroneous claims...
  77. doi Biological activities of sulfated polysaccharides from tropical seaweeds
    L S Costa
    UFRN, Laboratório de Biotecnologia de Polímeros Naturais Biopol, Centro de Biociencias, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Av Sen Salgado Filho, 3000, 59072970 Natal, Rio Grande do Norte, Brazil
    Biomed Pharmacother 64:21-8. 2010
    ....
  78. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
    ..There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation...
  79. doi Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows
    Domenico Pratico
    Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Ann N Y Acad Sci 1147:70-8. 2008
    ..This article will review both promises and caveats of the available data and propose future directions to be taken for addressing them...
  80. pmc Vitamin E, antioxidant and nothing more
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 43:4-15. 2007
    ..it seems unlikely that these pathways are specifically under the control of alpha-tocopherol given that various antioxidants other than alpha-tocopherol and various oxidative stressors can manipulate their responses...
  81. ncbi Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Free Radic Biol Med 41:1727-46. 2006
    ..These observations led to the hypothesis that dietary flavonoids play a significant role as antioxidants in vivo, thereby reducing chronic disease risk...
  82. pmc Method for the measurement of antioxidant activity in human fluids
    D Koracevic
    Institute of Biochemistry, Medical Faculty, University Clinical Center, Nis, Yugoslavia
    J Clin Pathol 54:356-61. 2001
    ..To develop a new, simple, and cheap method for estimating antioxidant activity in human fluids...
  83. ncbi Beneficial effects of green tea--a review
    Carmen Cabrera
    Departamento de Nutricion y Bromatologia, Facultad de Farmacia, Campus Universitario de Granada, Granada, Spain
    J Am Coll Nutr 25:79-99. 2006
    ..Catechins are in vitro and in vivo strong antioxidants. In addition, its content of certain minerals and vitamins increases the antioxidant potential of this type of ..
  84. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
    ..The lungs are therefore endowed with an armamentarium of a battery of endogenous agents called antioxidants. The antioxidant species help the lungs ward off the deleterious consequences of a wide variety of oxidants/..
  85. doi Function of marine carotenoids
    Kazuo Miyashita
    Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Japan
    Forum Nutr 61:136-46. 2009
    ..The key structure of carotenoids for the expression of antiobesity effect was suggested to be carotenoid end of the polyene chromophore containing an allenic bond and two hydroxyl groups...
  86. ncbi Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
    Aruna Kode
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 294:L478-88. 2008
    ..These data may have implications in dietary modulation of antioxidants in treatment of chronic obstructive pulmonary disease.
  87. ncbi Flavonoid antioxidants
    C Rice-Evans
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases, Guy s, King s and St Thomas School of Biomedical Sciences, Hodgkin Building, Guy s Campus, London, SE1 9RT, UK
    Curr Med Chem 8:797-807. 2001
    In order to ascertain the role of dietary flavonoids as antioxidants in vivo it is necessary to understand the chemical nature of the absorbed forms in the circulation in vivo and how the multiplicity of research findings in vitro reflect ..
  88. ncbi Reactive oxygen species in mitochondria-mediated cell death
    Sten Orrenius
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Drug Metab Rev 39:443-55. 2007
    ..Taken together, these findings have placed the mitochondria in the focus of current cell death research...
  89. pmc Preliminary phytochemical screening and in vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC
    Olayinka A Aiyegoro
    Applied and Environmental Microbiology Research Group AEMREG, Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa
    BMC Complement Altern Med 10:21. 2010
    ..A lot of researches are going on worldwide directed towards finding natural antioxidants of plants origins...
  90. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  91. ncbi Nrf2 signaling in coordinated activation of antioxidant gene expression
    Anil K Jaiswal
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Free Radic Biol Med 36:1199-207. 2004
    ..The future studies should also reveal a complete mechanism of signal transduction from antioxidants and xenobiotics to the transcription factors, such as Nrf2, that bind to ARE.
  92. doi Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
    John D Hayes
    Biomedical Research Institute, Ninewells Hospital, University of Dundee, Scotland, United Kingdom
    Antioxid Redox Signal 13:1713-48. 2010
    ....
  93. ncbi Oxidative stress markers in aqueous humor of glaucoma patients
    Sandra M Ferreira
    Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologica, CONICET, Buenos Aires, Argentina
    Am J Ophthalmol 137:62-9. 2004
    ..For this purpose the authors measured the total reactive antioxidant potential (TRAP) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase...
  94. ncbi Neurodegenerative diseases and oxidative stress
    Kevin J Barnham
    Department of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Victoria 3010, Australia
    Nat Rev Drug Discov 3:205-14. 2004
    ..However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies...
  95. ncbi Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress
    Andy Y Shih
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Neurosci 23:3394-406. 2003
    ..Neuroprotection was not limited to overexpression of Nrf2, because activation of endogenous glial Nrf2 by the small molecule ARE inducer, tert-butylhydroquinone, also protected against oxidative glutamate toxicity...
  96. ncbi Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 94:768-75. 2004
    ..1 micromol/L), had also effects similar to those of N-acetylcysteine. We conclude that both antioxidants and statins can delay the onset of replicative senescence by counteracting the increased ROS production linked ..
  97. ncbi Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment
    D R Evans
    Department of Psychiatry and Health Behavior, Medical College of Georgia, GA, USA
    Prostaglandins Leukot Essent Fatty Acids 69:393-9. 2003
    ..These data also support the augmentation of antipsychotic treatment by supplementation with a combination of antioxidants and omega-3 fatty acids.
  98. doi Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
    Felicity Ng
    Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Vic, Australia
    Int J Neuropsychopharmacol 11:851-76. 2008
    ..of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by ..
  99. doi Fucoidan protects against dopaminergic neuron death in vivo and in vitro
    Dingzhen Luo
    Key Laboratory of Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, PR China
    Eur J Pharmacol 617:33-40. 2009
    ..Taken together, these findings suggest that fucoidan has protective effect in MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative activity...
  100. ncbi Antioxidant response to oxidative stress induced by exhaustive exercise
    Antoni Aguilo
    Laboratori de Ciències de l Activitat Física and Department de Biologia Fonamental i Ciències de la Salut, Edifici Guillem Colom, Facultat de Ciencies, Universitat de les Illes Balears, Palma de Mallorca, Balears, Spain
    Physiol Behav 84:1-7. 2005
    ..A specific utilisation of alpha-tocopherol against oxidative stress during recovery was evidenced...
  101. ncbi Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease
    R Soto-Otero
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Santiago de Compostela, Spain
    J Neurochem 74:1605-12. 2000
    ..In this study we examine the effects of the antioxidants ascorbic acid (AA), glutathione (GSH), cysteine (CySH), and N-acetyl-CySH (NAC) on the autoxidation and ..

Research Grants81

  1. DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUES
    YOGESH AWASTHI; Fiscal Year: 1993
    ..system, they will establish the optimal conditions of induction of GSH, GST and GSH-Px by BHT and other dietary antioxidants and investigate the effects of antioxidants on individual GST isoenzymes and all the three forms of GSH-Px ..
  2. The Role of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal Dys
    Ula V Jurkunas; Fiscal Year: 2010
    ..Our preliminary studies have identified a decrease in the antioxidant response element (ARE)-driven antioxidants, overexpression of extracellular and stress-related proteins, and an increase in the levels of oxidized ..
  3. Treatment of SLE with N-acetylcysteine
    Andras Perl; Fiscal Year: 2010
    ..GSH is also depleted in lymphocytes of lupus-prone mice and NAC and other antioxidants reduce autoantibody production, prevent the development of glomerulonephritis, and prolong the survival of ..
  4. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  5. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2010
    Although oxidative stress is a hallmark of heart failure (HF), clinical trials with antioxidants targeting first generation reactive oxygen species (ROS) such as O2/ and H2O2 have not yielded compelling benefits...
  6. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2010
    ..To address this hypothesis, we will measure lipid peroxidation and protein carbonylation products as well as antioxidants in the lungs and blood after room air exposure or at various times after acute O3 exposure...
  7. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..This is "oxidative stress" as a result of a chronic or acute rise in Reactive Oxygen Species (ROS). Antioxidants and over-expression of antioxidant enzymes have been shown to inhibit the progression of many retinal diseases...
  8. DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUES
    YOGESH AWASTHI; Fiscal Year: 1992
    ..system, they will establish the optimal conditions of induction of GSH, GST and GSH-Px by BHT and other dietary antioxidants and investigate the effects of antioxidants on individual GST isoenzymes and all the three forms of GSH-Px ..
  9. Mechanisms and Prevention of Etoposide-Induced Leukemia
    Jack Yalowich; Fiscal Year: 2009
    ..It is also posited that nutritional antioxidants such as vitamin C and vitamin E homologs will prevent VP-16-induced AML by reducing or preventing production of ..
  10. HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and Antioxidants
    Marianna Baum; Fiscal Year: 2007
    ..of hepatic damage leading to fibrosis in hepatitis C and is accompanied by decreased plasma micronutrient antioxidants. While many studies confirm the presence of elevated oxidative stress in HIV and in HCV mono-infections, no ..
  11. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    James McGinnis; Fiscal Year: 2009
    ..This is "oxidative stress" as a result of a chronic or acute rise in Reactive Oxygen Species (ROS). Antioxidants and over-expression of antioxidant enzymes have been shown to inhibit the progression of many retinal diseases...
  12. HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and Antioxidants
    Marianna K Baum; Fiscal Year: 2010
    ..of hepatic damage leading to fibrosis in hepatitis C and is accompanied by decreased plasma micronutrient antioxidants. While many studies confirm the presence of elevated oxidative stress in HIV and in HCV mono-infections, no ..
  13. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..Vitamins and minerals contribute to the oxidative defense system because: (1) they are antioxidants (vitamins E, C and B-carotene); (2) they are essential for the function of enzyme antioxidants (Zn, Cu, Fe, Mn, ..
  14. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
    ..oxidative stress hypothesis of aging using transgenic mouse models in which the balance between prooxidants and antioxidants is altered so that the steady state accumulation of oxidative damage is accelerated...
  15. Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective Analysis
    A Heather Eliassen; Fiscal Year: 2010
    ..we propose several studies to substantially improve our understanding of the role of oxidative stress and antioxidants in breast carcinogenesis...
  16. Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective Analysis
    A Heather Eliassen; Fiscal Year: 2009
    ..we propose several studies to substantially improve our understanding of the role of oxidative stress and antioxidants in breast carcinogenesis...
  17. Peroxiredoxin 6 and Cataractogenesis
    DHIRENDRA SINGH; Fiscal Year: 2009
    ..Age-Related Cataract, and suggests that aged lens cells are prone to this damage due to reduced expression of antioxidants. Because ocular lens is constantly exposed to environmental stress, it continuously generates reactive oxygen ..
  18. BIOLOGIC ACTIVITY OF BETA-CAROTENE METABOLITES
    Robert Russell; Fiscal Year: 2005
    ..results in increased lung cell oxidative stress, thereby causing decreased tissue levels of other important antioxidants, such as ascorbate and alpha-tocopherol, which have a stabilizing effect on unoxidized beta-carotene...
  19. Cardiovascular Effects of Scutellaria baicelensis
    Chun Su Yuan; Fiscal Year: 2002
    ..nontraditional antioxidants may play in its acute treatment...
  20. Mechanisms of PCP genotoxicity & antioxidant modulation
    BENZHAN ZHU; Fiscal Year: 2002
    ..through a novel, metal-independent mechanism (the so-called organic Fenton reaction); and that dietary antioxidants markedly inhibit -OH production from PCP metabolites...
  21. RICKETTSIA RICKETTSII IN HUMAN ENDOTHELIAL CELLS
    David Silverman; Fiscal Year: 2002
    ..With an interest in abrogating endothelial cell injury, they have incorporated antioxidants into infected cell culture systems...