Summary: Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
Publications221 found, 100 shown here
- The role of protein digestibility and antacids on food allergy outcomesEva Untersmayr
Department of Pathophysiology, Center of Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 121:1301-8; quiz 1309-10. 2008..Thus antiulcer agents impeding gastric protein digestion have a major effect on the sensitization and effector phase of food allergy...
- Evaluation of the buffering capacity of powdered cow's, goat's and soy milk and non-prescription antacids in the treatment of non-ulcer dyspepsiaD Lutchman
School of Pharmacy and Pharmacology, University of KwaZulu Natal, Durban, South Africa
S Afr Med J 96:57-61. 2006..Treatment choice commonly includes over the counter medicines and home remedies, e.g. milk...
- Pharmacokinetics of rifampin under fasting conditions, with food, and with antacidsC A Peloquin
Department of Medicine, National Jewish Medical and Research Center, School of Pharmacy, University of Colorado, Denver 80206, USA
Chest 115:12-8. 1999Determine the intrasubject and intersubject variability in, and the effects of food or antacids on, the pharmacokinetics of rifampin (RIF).
- Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trialCorine J Van Marrewijk
Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Lancet 373:215-25. 2009..We compared step-up and step-down treatment strategies for initial management of patients with new onset dyspepsia in primary care...
- Prevention of irinotecan (CPT-11)-induced diarrhea by oral alkalization combined with control of defecation in cancer patientsY Takeda
Department of Respiratory Medicine, International Medical Center of Japan, Tokyo, Japan
Int J Cancer 92:269-75. 2001..Risk factors statistically associated with delayed diarrhea include advanced age and the use of CPT-11 without OA and CD...
- Arrest of chronic acid suppressant drug use after successful Helicobacter pylori eradication in patients with peptic ulcer disease: a six-month follow-up studyG J Hurenkamp
Department of General Practice, Academic Medical Centre, Meibergdreef 9, Amsterdam, The Netherlands
Aliment Pharmacol Ther 15:1047-54. 2001..pylori eradication leads to relief of dyspepsia and the subsequent arrest or tapering of acid-suppressant drug therapy, or to an aggravation of acid-related dyspepsia requiring more acid-suppressant drug intake...
- Concomitant prescription of non-steroidal anti-inflammatory drugs and antacids in the outpatient setting of a medical center in taiwan: a prescription database studyJ Y Liu
Department of Family Medicine, Taipei Veterans General Hospital, Taiwan
Eur J Clin Pharmacol 57:505-8. 2001OBJECTIVE: Although antacids were ineffective in preventing serious gastrointestinal complications caused by non-steroidal anti-inflammatory drugs (NSAIDs), many physicians in Taiwan still prescribe antacids concomitantly with NSAIDs...
- Effects of food and antacids on the pharmacokinetics of eltrombopag in healthy adult subjects: two single-dose, open-label, randomized-sequence, crossover studiesDaphne D Williams
GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Clin Ther 31:764-76. 2009..Eltrombopag is the first orally self-administered, small-molecule, nonpeptide thrombopoietin receptor agonist for the treatment of chronic idiopathic thrombocytopenic purpura...
- Pharmacokinetics of cycloserine under fasting conditions and with high-fat meal, orange juice, and antacidsM Zhu
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Pharmacotherapy 21:891-7. 2001STUDY OBJECTIVES: To determine the effect of a high-fat meal, orange juice, and antacids on absorption of a single oral dose of cycloserine and to estimate its population pharmacokinetic parameters...
- Aluminum-containing antacids as a cause of idiopathic Parkinson's diseaseE Altschuler
UC San Diego School of Medicine, La Jolla, CA 92092 0606, USA
Med Hypotheses 53:22-3. 1999..Aluminum is thought to be a cellular toxin. Here I suggest that aluminum, and in particular aluminum-containing antacids may contribute to the pathogenesis of idiopathic PD.
- Lack of pharmacokinetic interaction between the oral anti-influenza neuraminidase inhibitor prodrug oseltamivir and antacidsPaul Snell
Department of Research and Development, Roche Products Ltd, Welwyn Garden City, Hertfordshire, UK
Br J Clin Pharmacol 54:372-7. 2002....
- Effect of food and antacids on the pharmacokinetics of pirfenidone in older healthy adultsC M Rubino
Institute for Clinical Pharmacodynamics, Ordway Research Institute, 43 British American Boulevard, Latham, NY 12110, USA
Pulm Pharmacol Ther 22:279-85. 2009..single-dose crossover study, the pharmacokinetics (PK) of pirfenidone were investigated with or without food and antacids in healthy adult volunteers...
- How do primary care physicians use long-term acid suppressant drugs? A population-based analysis of Dutch general practicesG J B Hurenkamp
Dept of General Practice, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
J Fam Pract 51:241-5. 2002..We investigated the magnitude of long-term prescription of acid suppressant drugs in general practice and the frequency and means of confirming the primary working diagnosis...
- Application of a data-mining technique to analyze coprescription patterns for antacids in TaiwanTzeng Ji Chen
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Clin Ther 25:2453-63. 2003Although antacids are popular drugs with a long history of use, their true utilization patterns-including over-the-counter use-have rarely been documented...
- Maintenance treatment is not necessary after Helicobacter pylori eradication and healing of bleeding peptic ulcer: a 5-year prospective, randomized, controlled studyChen-Chiung Liu
Division of Gastroenterology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan
Arch Intern Med 163:2020-4. 2003..In addition, the 1-week proton pump inhibitor-based triple therapy had the efficacy to ensure long-term eradication of H pylori in a region of high prevalence...
- [Pharmacological efficacy of bismuth tripotassium dicitrate in peptic ulcer]Iu B Belousov
Ter Arkh 79:58-66. 2007
- Ambulatory intragastric pH monitoring: clinical laboratory to clinical practicePhillip O Katz
Division of Gastroenterology and Nutrition, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA
Rev Gastroenterol Disord 3:S3-9. 2003..These laboratory experiences can be used in clinical practice to aid in management of patients with gastroesophageal reflux disease...
- Gastroesophageal reflux disease: current treatment approachesWendy Biddle
Director 11:155-9. 2003
- [Treatment of laryngeal granuloma with anti-extraesophageal reflux medication]J P Benaixa
Servicio de Otorrinolaringologia, Hospitales Universitarios Virgen del Rocio, Sevilla
Acta Otorrinolaringol Esp 54:501-5. 2003..To asses the role of Gastroesophageal reflux in the genesis of laryngeal granulomas...
- Gastroesophageal reflux disease--state of the artP O Katz
Graduate Hospital, MCP-Hahnemann School of Medicine, Philadelphia, PA, USA
Rev Gastroenterol Disord 1:128-38. 2001..Endoscopic therapy for reflex should be considered as an experimental technology needing continuing evaluation...
- [As-needed treatment with gastric acid inhibitors in gastroesophageal reflux disease]A C Poen
Meander Medisch Centrum, afd Interne Geneeskunde en Gastroenterologie, Amersfoort
Ned Tijdschr Geneeskd 147:1632-6. 2003..All antacids can in principle be used for on-demand treatment; for type 3 treatment, antacids with a rapid onset of action are ..
- On-demand and intermittent therapy for gastro-oesophageal reflux disease: economic considerationsJohn M Inadomi
VA Center for Practice Management and Outcomes Research and the University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA
Pharmacoeconomics 20:565-76. 2002..b>Antacids, alginates, topically active agents, histamine(2)-receptor antagonists, and proton pump inhibitors have all ..
- [The treatment of peptic ulcer in elderly CRF patients]Hitoshi Iwabuchi
Department of Internal Medicine, Tsurumi Westside Hospital
Nippon Rinsho 60:1601-5. 2002..It is needless to say that special attentions should be always paid for doses, intervals or durations in any drugs prescribed for elderly CRF patients because of lower renal metabolic clearance rates for drugs...
- Gastric acid suppression and the risk of enteric peritonitis in peritoneal dialysis patientsSharon J Nessim
Division of Nephrology, University of Toronto, Toronto, Ontario, Canada
Perit Dial Int 28:246-51; discussion 236-7. 2008..The objective of this study was to determine, using a larger patient population, whether gastric acid suppressants are associated with an increased risk of EP. Patients and..
- Current trends in the treatment of upper gastrointestinal diseaseGeorge Sachs
Geffen School of Medicine at UCLA and GWLA Health Center, Los Angeles, USA
Best Pract Res Clin Gastroenterol 16:835-49. 2002..Research continues in an attempt to find improved means of acid control and better methods for the eradication of H. pylori based on unique proteins expressed by the organism to resist gastric acidity...
- [Heartburn without esophagitis. Symptoms more important than the finding?]H S Fuessl
MMW Fortschr Med 145:4-6. 2003
- [Modern attitude towards management of laryngopharyngeal form of gastroesophageal reflux disease. Lithuanian clinical practice guidelines for adults]Nora Siupsinskiene
Department of Otorhinolaryngology, Kaunas University of Medicine, Kaunas, Lithuania
Medicina (Kaunas) 43:832-9. 2007..Combined therapy for nonresponders is described. Algorithm for stopping the medication is recommended. These recommendations may provide an efficient and economical approach to the management of this problem...
- Therapeutic approaches to reflux disease, focusing on acid secretionYoshikazu Kinoshita
Department of Internal Medicine II, Shimane Medical University, 89-1 Enya-cho, Izumo 693-8501, Japan
J Gastroenterol 38:13-9. 2003..For these patients, addition of H2RAs to PPIs can be useful for controlling GERD, at least for short-term treatment. For long-term control of such cases, further studies are necessary...
- Medical management of nocturnal symptoms of gastro-oesophageal reflux disease in the elderlySamer Gawrieh
Division of Gastroenterology and Hepatology, Department of Medicine, MCW Dysphagia Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Drugs Aging 20:509-16. 2003..Histamine H(2) receptor antagonists are suitable for mild-to-moderate ENRD. Antacids and lifestyle modifications may be incorporated into the management as adjuncts to more potent and durable ..
- Appropriate management of symptomatic GORD in primary care: has expert opinion changed between 2001 and 2005?Jan Tack
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Acta Gastroenterol Belg 70:171-6. 2007..To determine current opinions of clinical experts on the appropriate management of symptomatic GORD in primary care, and to compare these opinions with those from a similar study conducted in 2001...
- [Dyspepsia and reflux. Systematic literature review from SBU]Christer Staël von Holstein
Kirurgiska kliniken, Universitetssjukhuset Lund
Lakartidningen 104:1414-7. 2007
- [On-demand treatment with gastric acid inhibitors for gastroesophageal reflux disease]C B Lamers
Leids Universitair Medisch Centrum, afd Maag, Darm en Leverziekten, Postbus 9600, 2300 RC Leiden
Ned Tijdschr Geneeskd 147:1630-2. 2003..In this approach, the patient determines the actual therapy whereas the physician functions as advisor. It is presently unknown whether any adverse effects result from the long-term on-demand therapy of reflux disease...
- Predictive factors of the long-term outcome in reflux esophagitis in a low-prevalence gastroesophageal reflux disease regionC S Chang
Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
Scand J Gastroenterol 38:1131-5. 2003..In this study the outcome and the specific prognostic indicators associated with outcome in patients were assessed retrospectively, 7 years after diagnosis of esophagitis...
- Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary diseaseRachel M Thomson
MBBS, Department of Thoracic Medicine, The Prince Charles Hospital, Rode Rd, Chermside, QLD, Australia
Chest 131:1166-72. 2007....
- The pharmacological management of gastroesophageal reflux diseaseR C Lowe
Boston University School of Medicine, Boston Medical Center, Boston, USA
Minerva Gastroenterol Dietol 50:227-37. 2004..A treatment schema for GERD based on presenting symptoms is outlined, promoting a stepwise approach to the appropriate use of antisecretory therapy...
- PPI use in the OTC era: who to treat, with what, and for how long?John M Inadomi
Division of Gastroenterology, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Clin Gastroenterol Hepatol 3:208-15. 2005..The availability of over-the-counter (OTC) and generic PPIs provides consumers with options other than antacids and histamine 2 -receptor antagonists (H2RAs) for self-medication of heartburn and acid regurgitation...
- Prognostic influence of Barrett's oesophagus and Helicobacter pylori infection on healing of erosive gastro-oesophageal reflux disease (GORD) and symptom resolution in non-erosive GORD: report from the ProGORD studyP Malfertheiner
Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
Gut 54:746-51. 2005..We report on factors influencing endoscopic healing and symptom resolution during the acute treatment phase...
- Acid suppressive therapy use on an inpatient internal medicine serviceCo Q D Pham
Faculty of Pharmacy, University of Montreal, Quebec, Canada
Ann Pharmacother 40:1261-6. 2006..CONCLUSIONS: There is considerable excess usage of acid suppressants in both the inpatient and outpatient settings...
- Gastro-oesophageal reflux diseasePaul Moayyedi
Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, ON, Canada
Lancet 367:2086-100. 2006..The role of endoscopic therapy is uncertain. Anti-reflux surgery is probably as effective as PPI therapy although there is a low operative mortality and morbidity...
- Heartburn: issues in patient management. A roundtable discussionGoutham Rao
University of Pittsburgh School of Medicine, PA, USA
J Fam Pract 54:s1-6. 2005
- Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance oF Pace
Department of Gastroenterology, Luigi Sacco University Hospital, Via G B Grassi, 74, 20157 Milan, Italy
Dig Liver Dis 37:741-50. 2005..However, such studies have been conducted as superiority studies but interpreted as equivalence ones...
- Helicobacter pylori seropositivity predicts outcomes of acid suppression therapy for laryngopharyngeal reflux symptomsNobuhiko Oridate
Department of Otolaryngology Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Laryngoscope 116:547-53. 2006..The effects of H. pylori infection on outcomes of acid suppression therapy have not been studied...
- [Is the successful eradication of Helicobacter pylori sufficient for the healing of peptic ulcer?]Istvan Pregun
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika
Orv Hetil 147:435-9. 2006..There are less data available concerning gastric ulcer: successful eradication is also essential to ulcer healing and to avoid relapse, however it seems that post-eradication PPI therapy might be beneficial...
- Complications and antireflux medication use after antireflux surgeryJason A Dominitz
Northwest Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, Washington 98108 1597, USA
Clin Gastroenterol Hepatol 4:299-305. 2006..The aim of this study was to estimate postoperative complications and continued use of antireflux medications and to identify predictors of complications...
- Acid-suppressing drugs and gastroesophageal reflux disease as risk factors for acute pancreatitis--results from a Swedish Case-Control StudyAnders Sundström
Medical Products Agency, Uppsala, Sweden
Pharmacoepidemiol Drug Saf 15:141-9. 2006..To study risk factors for acute pancreatitis, here with emphasis on gastro-intestinal diseases and their treatments...
- A long-term comparison of plication configurations for endoluminal gastroplication: circumferential versus helicalRichard E Davis
Department of Surgery, Creighton University School of Medicine, 601 N. 30th Street, Omaha, NE 68131, USA
J Clin Gastroenterol 39:869-76. 2005..CONCLUSION: ELGP improves heartburn and regurgitation scores at 18 months. Our study suggests that there is no benefit to additional plications when using the helical pattern...
- Rebound acid hypersecretion after long-term inhibition of gastric acid secretionR Fossmark
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Aliment Pharmacol Ther 21:149-54. 2005..Rebound acid hypersecretion develops after the use of acid inhibitors...
- The effect of acid suppression on sleep patterns and sleep-related gastro-oesophageal refluxW C Orr
Lynn Institute for Healthcare Research, Oklahoma City, OK, USA
Aliment Pharmacol Ther 21:103-8. 2005..Several studies have demonstrated that night-time gastro-oesophageal reflux affects sleep quality, and thereby impairs daytime functioning...
- Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tubeT Yamaguchi
Department of Hospital Pharmacy, Isahaya Ryoiku Center, Nagasaki, Japan
Int J Clin Pharmacol Ther 42:594-6. 2004..Thus, administration of pulverized omeprazole concomitantly with antacid via a fine nasogastric tube may provide a novel approach for the treatment of chronic GER in pediatric patients with SMID...
- [Treatment of gastroesophageal reflux in pregnant women]Jan G Hatlebakk
Medisinsk avdeling, Haukeland Universitetsykehus, 5021 Bergen
Tidsskr Nor Laegeforen 124:797-8. 2004
- Effect of proton pump inhibitors and antacid therapy on 13C urea breath tests and stool test for Helicobacter pylori infectionLuigi Gatta
Department of Internal Medicine and Gastroenterology, University of Bologna, S. Orsola Halpighi Hospital, Bologna, Italy
Am J Gastroenterol 99:823-9. 2004..CONCLUSIONS: False negative breath and stool tests are equally common in patients taking proton pump inhibitors. Antacids do not impair the sensitivity of the breath tests or the stool test.
- The management of upper gastrointestinal symptoms: is endoscopy indicated?Anne E Duggan
Med J Aust 186:166-7. 2007
- [GERD. Introduction]Tsutomu Chiba
Department of Gastroenterology and Hepatology, Graduate School of Medicine and Faculty of Medicine, Kyoto University
Nippon Rinsho 62:1411-4. 2004..Thus, an effort for improving both sensitivity and specificity of the diagnosing method for NERD is required. In any event, it should be kept in mind that pathophysiology of GERD is quite different between Western and Japanese patients...
- [PPI: new strategies for GERD]Etsuo Hoshino
Department of Internal Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research
Nippon Rinsho 62:1570-6. 2004..A small number of GERD patients resistant to PPI therapy may be due to nocturnal acid breakthrough (NAB) or rapid metabolism of PPI (extensive metabolizer for CYP2C19)...
- Acid reflux and gastro-oesophageal reflux diseaseAlan R Watson
University Hospital, Queen's Medical Centre, Nottingham, UK
Br J Community Nurs 9:326-30. 2004..This article describes the symptoms and diagnosis of acid reflux and GORD, and reviews currently available treatments ranging from lifestyle modification to surgery...
- Role of gastroesophageal reflux symptoms in exacerbations of COPDIvan E Rascon-Aguilar
University of Florida Health Science Center/Jacksonville, Division of Gastroenterology, 4555 Emerson Expressway, Suite 300, Jacksonville, FL 32207, USA
Chest 130:1096-101. 2006..2/yr vs 1.6/yr, p = 0.02). CONCLUSIONS: The presence of GER symptoms appears to be associated with increased exacerbations of COPD...
- [Eradication of Helicobacter pylori and use of antisecretory drugs--a population based study]Annmarie Touborg Lassen
Odense Universitetshospital, medicinsk gastroenterologisk afdeling S
Ugeskr Laeger 166:3405-7. 2004
- [Dosaging of proton pumps inhibitors]Odd Brørs
Seksjon for klinisk farmakologi og toksikologi, Klinisk kjemisk avdeling, Ulleval universitetssykehus, 0407 Oslo
Tidsskr Nor Laegeforen 126:2397-9. 2006
- Pantoprazole provides rapid and sustained symptomatic relief in patients treated for erosive oesophagitisW J Bochenek
Clinical Research and Development, Wyeth Research, Collegeville, PA, USA
Aliment Pharmacol Ther 20:1105-14. 2004..Relief of GERD symptoms is highly predictive of healing of erosive oesophagitis at 4 and 8 weeks...
- Review article: treatment for gastro-oesophageal reflux disease--lifestyle advice and medicationY Kinoshita
Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Shimane 693 8501, Japan
Aliment Pharmacol Ther 20:19-23. 2004..Pharmacological therapy is, however, usually also required for effective symptom relief. While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of ..
- Heartburn in primary care: problems below the surfaceGerald Holtmann
Division of Internal Medicine, Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
J Gastroenterol 39:1027-34. 2004..This review discusses the symptoms and risk factors associated with GERD, possible links to Helicobacter pylori infection, and effective treatment strategies within a primary care setting...
- Treatment of gastroesophageal reflux diseaseMichael Pettit
Clinical Pharmacy Unit, Royal Sussex Country Hospital, University of Brighton, Eastern Road, Brighton, BN2 5BE, UK
Pharm World Sci 27:432-5. 2005..Published manuscripts were identified from Medline. The articles were then screened for relevance prior to inclusion in the review...
- [Stress ulcer]Kimitoshi Kato
Third Department of Internal Medicine, Nihon University School of Medicine
Nippon Rinsho 60:619-24. 2002
- Medical therapy of gastroesophageal reflux disease in secondary and tertiary care settingsG N Tytgat
Department of Gastroenterology and Hepatology, University of Amsterdam, Academic Medical Center, The Netherlands
Yale J Biol Med 72:219-26. 1999..pylori infected individuals. Optimization of individualized therapy will require more potent and more precisely targeted motility modulating drugs and superior acid/peptic inhibiting pharmaceuticals...
- [PPI plus bismuth-based quintuple therapy]Ken Kimura
Kimura GE Clinic
Nippon Rinsho 63:452-8. 2005
- A randomized trial of lansoprazole, amoxycillin, and clarithromycin versus lansoprazole, bismuth, metronidazole and tetracycline in the retreatment of patients failing initial Helicobacter pylori therapyN Magaret
Department of Medicine, Sections of Gastroenterology, Oregon Health Sciences University, Portland, OR 97201, USA
Dig Dis 19:174-8. 2001..To determine whether LAC or LBMT is as effective for retreating patients failing non-metronidazole-containing regimens requires further study...
- [Continuation of acid suppression therapy after H. pylori eradication]Morio Takahashi
Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University of Medicine
Nippon Rinsho 60:531-5. 2002
- [GERD/reflux esophagitis]Michio Hongo
Department of Comprehensive Medicine, Tohoku University Hospital
Nippon Rinsho 60:608-13. 2002
- Maintenance therapy for duodenal ulcer: a randomized controlled comparison of seven forms of treatmentW M Hui
Department of Medicine, University of Hong Kong, Queen Mary Hospital
Am J Med 92:265-74. 1992We performed a randomized controlled trial to compare the efficacy of seven forms of maintenance treatment of duodenal ulcer, including a mealtime regimen of antacids.
- Delavirdine: clinical pharmacokinetics and drug interactionsJ Q Tran
Agouron Pharmaceuticals, Inc, A Pfizer Company, La Jolla, California, USA
Clin Pharmacokinet 40:207-26. 2001..Reduction in gastric acidity (pH > 3) decreases the extent of delavirdine absorption, so administration of antacids and the buffered formulations of didanosine should be separated from that of delavirdine by at least 1 hour...
- Gastroesophageal reflux disease: pathophysiology and pharmacology overviewE Z Dajani
International Drug Development Consultants IDDC Corporation, Long Grove, Illinois 60047 9532, USA
J Assoc Acad Minor Phys 11:7-11. 2000..b>Antacids, prokinetics, and gastric antisecretory agents are the principal drugs currently used to treat GERD in ..
- Lack of effect of simultaneously administered didanosine encapsulated enteric bead formulation (Videx EC) on oral absorption of indinavir, ketoconazole, or ciprofloxacinBharat D Damle
Clinical Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Bristol Myers Squibb Company, Princeton, New Jersey 08543, USA
Antimicrob Agents Chemother 46:385-91. 2002..can result in a significant decrease in the oral absorption of certain drugs because of interactions with antacids. An enteric formulation of didanosine is unlikely to cause such drug interactions because it lacks antacids...
- Canadian Consensus Conference on the management of gastroesophageal reflux disease in adults - update 2004David Armstrong
Division of Gastroenterology, McMaster University, Hamilton
Can J Gastroenterol 19:15-35. 2005..Since the last Canadian Consensus Conference in 1996, GERD management has evolved substantially...
- Review article: alginate-raft formulations in the treatment of heartburn and acid refluxK G Mandel
SmithKline Beecham Consumer Health Care, Parsippany, NJ 07054, USA
Aliment Pharmacol Ther 14:669-90. 2000..of heartburn and oesophagitis, and appear to act by a unique mechanism which differs from that of traditional antacids. In the presence of gastric acid, alginates precipitate, forming a gel...
- Impact on human health of Salmonella spp. on pork in The Netherlands and the anticipated effects of some currently proposed control strategiesB R Berends
Department of the Science of Food of Animal Origin, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
Int J Food Microbiol 44:219-29. 1998..as neoplasms or diabetes mellitus (1200 cases/100,000 pyar); (2) persons with achlorhydria or who excessively use antacids (1100 cases/100,000 pyar); (3) persons who have recently been treated with antibiotics that disturb the normal ..
- A critical review of the fluoroquinolones: focus on respiratory infectionsGeorge G Zhanel
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Drugs 62:13-59. 2002..Drug interactions are limited; however, all fluoroquinolones interact with metal ion containing drugs (eg. antacids)...
- Pharmacokinetic investigation of a nicotine sublingual tabletL Molander
Department of Clinical Pharmacology, Pharmacia and Upjohn Consumer Healthcare, Lund, Sweden
Eur J Clin Pharmacol 56:813-9. 2001..To evaluate the pharmacokinetics of a new 2-mg nicotine sublingual tablet under varying conditions of use...
- Hospital-acquired diarrhea in adults: a prospective case-controlled study in MexicoM Zaidi
Department of Infectious Diseases, , , Mexico City, Mexico
Infect Control Hosp Epidemiol 12:349-55. 1991..01). Multivariate analysis showed enteral feeding, recent enemas, presence of Candida species, use of antacids/H2-blockers, and presence of nasogastric tubes as significant risk factors for nosocomial diarrhea...
- Clinical experience with pantoprazole in gastroesophageal reflux diseaseD L Avner
Gastroenterology, St Mark s Hospital, Salt Lake City, Utah 84124, USA
Clin Ther 22:1169-85; discussion 1149-50. 2000..Pantoprazole is a new proton pump inhibitor indicated for the treatment of erosive esophagitis associated with gastroesophageal reflux disease (GERD) and is available in both oral and intravenous (IV) formulations...
- Factors affecting solubility and penetration of clarithromycin through gastric mucusP Grubel
Division of Gastroenterology, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, MA 02135, USA
Aliment Pharmacol Ther 12:569-76. 1998..Factors influencing the pharmacokinetics of clarithromycin in gastric mucus are poorly defined...
- Current guidelines on stress ulcer prophylaxisM Tryba
Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Bergmannsheil, Bochum, Germany
Drugs 54:581-96. 1997..Preventive strategies aim to reduce gastric acidity (histamine H2 receptor antagonists, antacids), strengthen mucosal defensive mechanisms (sucralfate, antacids, pirenzepine) and normalise gastric mucosal ..
- Pharmacokinetics of para-aminosalicylic acid granules under four dosing conditionsC A Peloquin
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206 2762, USA
Ann Pharmacother 35:1332-8. 2001..To determine the pharmacokinetics and relative bioavailability of para-aminosalicylic acid (PAS) granules...
- Diagnosis of magnesium-induced diarrheaK D Fine
Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246
N Engl J Med 324:1012-7. 1991..The purposes of this study were to establish a method for diagnosing magnesium-induced diarrhea and to apply it to patients with chronic diarrhea...
- Review article: treatment of mild and severe cases of GERDG N J Tytgat
Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam Zuidoost, The Netherlands
Aliment Pharmacol Ther 16:73-8. 2002..of the bed, maintaining normal weight, and avoidance of foods and drugs that precipitate symptoms, together with antacids or over-the-counter H(2) receptor antagonists (H(2)RAs)...
- Applying data mining techniques in the development of a diagnostics questionnaire for GERDNoya Horowitz
Department of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Dig Dis Sci 52:1871-8. 2007..relevant variables discriminating GERD from non-GERD patients were heartburn, regurgitation, clinical response to antacids, sour taste, and aggravation of symptoms after a heavy meal...
- Black tongue secondary to bismuth subsalicylate: case report and review of exogenous causes of macular lingual pigmentationPhilip R Cohen
University of Houston Health Center, University of Houston, Houston, TX, USA
J Drugs Dermatol 8:1132-5. 2009..The ingestion of medications, including other antacids, analgesics, antidepressants, antihypertensives and several antimicrobials has been associated with the ..
- Helicobacter pylori-induced duodenal ulcer frequently coincides with gastro-oesophageal reflux diseaseD Mc Namara
Adelaide and Meath Hospital, Trinity College, Dublin, Eire
Dig Liver Dis 34:542-6. 2002..However, eradication of Helicobacter pylori in these patients with improvement in their condition and a return to normal lifestyle, weight gain and discontinuation of antacids may unmask pre-existing gastro-oesophageal reflux disease.
- On-demand treatment of gastro-oesophageal reflux symptoms: a comparison of ranitidine 75 mg with cimetidine 200 mg or placeboJ P Galmiche
Department of Gastroenterology and Hepatology, University of Nantes, France
Aliment Pharmacol Ther 12:909-17. 1998..To compare the effects of ranitidine 75 mg with those of either cimetidine 200 mg or placebo given on demand for relief of typical symptoms of gastro-oesophageal reflux disease during a 15-day period...
- Mechanisms of drug-induced diarrhoea in the elderlyR N Ratnaike
Department of Medicine, Queen Elizabeth Hospital, Woodville, Australia
Drugs Aging 13:245-53. 1998..A number of drugs cause osmotic diarrhoea including antacids containing magnesium trisilicate or hydroxide...
- Low-dose ranitidine for the relief of heartburnK A Pappa
Glaxo Wellcome Inc, Research Triangle Park, North Carolina 27709
Aliment Pharmacol Ther 13:459-65. 1999..Although many rely on self-medication with antacids for the relief of their symptoms, treatments that decrease gastric volume as well as increase the pH of refluxed ..
- Results of short-and long-term medical treatment of gastroesophageal reflux disease (GERD)T Pohle
Department of Medicine B, University of Munster, Germany
Langenbecks Arch Surg 385:317-23. 2000..SHORT-TERM TREATMENT: In the case of rare symptoms, control might be achieved by lifestyle modifications and by antacids or mucosal protectants taken on demand...
- Prevalence and axial length of hiatus hernia in patients, with nonerosive reflux disease: a prospective studySpiros N Sgouros
Department of Gastroenterology, Athens Naval Hospital, Athens, Greece
J Clin Gastroenterol 41:814-8. 2007..Our aim was to investigate the prevalence and axial length of hiatus hernia in patients with NERD, compared with patients with reflux esophagitis, Barrett esophagus, and controls...
- Gemifloxacin for the treatment of respiratory tract infections: in vitro susceptibility, pharmacokinetics and pharmacodynamics, clinical efficacy, and safetySujata M Bhavnani
Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, NY 12208, USA
Pharmacotherapy 25:717-40. 2005..absorption is greatly reduced when given with divalent and trivalent cation-containing compounds, such as antacids. Due to its potent activity against many common gram-positive and gram-negative respiratory pathogens, its proven ..
- Ten-year follow-up of a prospective, randomized trial of selective proximal vagotomy with ulcer excision and partial gastrectomy with gastroduodenostomy for treating corporeal gastric ulcerS Emas
Department of Surgery, Karolinska Hospital, Stockholm, Sweden
Am J Surg 167:596-600. 1994..group who had moderate dumping, patients classified as Visick III or IV had no symptoms during treatment with antacids or H2-blockers, or had asymptomatic ulcers and needed no treatment...
- [Drug interactions with antiepileptic agents]Klaus Turnheim
Institut fur Pharmakologie, Medizinische Universität Wien, Wien, Osterreich
Wien Klin Wochenschr 116:112-8. 2004..Other possible pharmacokinetic interactions are precipitation of antiepileptics in the stomach by antacids or sucralfate and displacement from plasmaprotein binding of one antiepileptic agent by another...
- Prevalence of symptoms of gastroesophageal reflux during childhood: a pediatric practice-based survey. Pediatric Practice Research GroupS P Nelson
Division of Gastroenterology, Northwestern University Medical School and Children s Memorial Medical Center, Chicago, IL 60614, USA
Arch Pediatr Adolesc Med 154:150-4. 2000....
- Pharmacokinetics of isoniazid under fasting conditions, with food, and with antacidsC A Peloquin
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Int J Tuberc Lung Dis 3:703-10. 1999To determine the intra- and intersubject variability in and the effects of food or antacids on the pharmacokinetics of isoniazid (INH).
- Prevention of recurrent ulcer bleeding, a multicentre study of the effect of ranitidine and trimipramine over one yearR Stave
Department of Medicine, Ulleval University Hospital, Oslo, Norway
Scand J Gastroenterol Suppl 124:55-62. 1986..of bleedings from peptic ulcers and erosions have been reported by a number of authors following treatment with antacids (1), H2-receptor blockers, cimetidine (2-15), a combination of cimetidine and tranexamic acid (16), cimetidine ..
- Pharmaceutical care and community pharmacists' understanding of bisphosphonate dosing informationW W Li
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
J Clin Pharm Ther 29:531-6. 2004....
- A Canadian physician survey of dyspepsia managementN Chiba
Surrey GI Clinic, Guelph, Ontario
Can J Gastroenterol 12:83-90. 1998..To determine the management of patients with new onset dyspepsia by Canadian family physicians...
- Hyperacidification and Pseudomonas infections in CFVojo Deretic; Fiscal Year: 2006..a connection between the CFTR defect and infection and inflammation in CF, and provide a basis for development of new chemotherapies using appropriately formulated antacids or inhibitors of pumps and ion channels.
- Magnesium and Asthma - Clinical TrialsJudith Stern; Fiscal Year: 2004..evaluate baseline Mg intake (diet, tap and bottled drinking water, vitamin-mineral supplements, laxatives, and antacids), and multiple measures of Mg status, such as total and free plasma Mg, and total and free erythrocyte Mg, and ..
- DETERMINANTS OF STABILITY & ASSEMBLY OF INTEGRAL MEMBRANE PROTEINSCLIFFORD ROBINSON; Fiscal Year: 2002..of all drugs marketed target a GPCR, including familiar drug classes such as antihypertensives, antihistamines, antacids, and anxiety control medications...
- MBRS-SCORE Biomedical Research at J C Smith UnivRuth Greene; Fiscal Year: 2006..Dr. Nsoki will be investigating the interface between aluminum hydroxides used as antacids and selected molecules of life.
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter James Kahrilas; Fiscal Year: 2010..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter Kahrilas; Fiscal Year: 2009..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter Kahrilas; Fiscal Year: 2005..abstract_text> ..
- THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASEDavid Graham; Fiscal Year: 2005..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter Kahrilas; Fiscal Year: 2007..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- GASTRIC ENTEROCHROMAFFIN LIKE CELL IN ULCER DISEASEGeorge Sachs; Fiscal Year: 1999..These data will allow a novel understanding of the peripheral regulation of gastric acid secretion as well as the exocytotic process in a non- excitable endocrine cell. ..
- Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical CenterBennett Amaechi; Fiscal Year: 2007..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
- THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENTGeorge Sachs; Fiscal Year: 2009..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
- An Intergenerational CBPR Intervention to Reduce Appalachian Health DisparitiesNancy Schoenberg; Fiscal Year: 2009....
- The Gastric Biology of Helicobacter PyloriGeorge Sachs; Fiscal Year: 2010..A better understanding of effects of acid inhibition on H. pylori may allow improvement or replacement of triple therapy for eradication. ..
- EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODEDavid Nix; Fiscal Year: 2009..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
- THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENTGeorge Sachs; Fiscal Year: 2004....
- GASTRIC BIOLOGY OF HELICOBACTER PYLORIGeorge Sachs; Fiscal Year: 2002..Understanding the means of survival and cytotoxicity of this pathogen will enable more rational treatment of peptic ulcer disease. ..
- Medication Adherence in Adolescents with HypertensionRenee Robinson; Fiscal Year: 2005..effective assessment methods to identify risk factors for non-adherence and to improve long-term medication adherence in children and adolescents suffering from chronic renal diseases, such as hypertension or solid organ transplantation ..
- Fluoride Agents: Pattern of their Effect on Early CariesBennett Amaechi; Fiscal Year: 2005..QLF data will be matched with their corresponding TMR data to determine the QLF parameters for lesions that were either completely remineralized or only arrested. ..
- EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODEDavid Nix; Fiscal Year: 2007..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
- Risk Factors for Barrett's EsophagusBrian Jacobson; Fiscal Year: 2007..M. Michael Wolfe, well-established investigators in health-services research. At the completion on the project, the candidate will have gained the experience to become an independent researcher in clinical epidemiology. ..
- Chemoprevention of IBD-Associated Colon CancerLAURA HALE; Fiscal Year: 2007..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
- GASTRIC BIOLOGY OF HELICOBACTER PYLORIGeorge Sachs; Fiscal Year: 2007..pylori has evolved to colonize the human stomach. These studies may provide targets to allow eradication of this class 1 carcinogen without the use of general antibiotics. ..