xylitol

Summary

Summary: A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.

Top Publications

  1. pmc Analysis and prediction of the physiological effects of altered coenzyme specificity in xylose reductase and xylitol dehydrogenase during xylose fermentation by Saccharomyces cerevisiae
    Stefan Krahulec
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12 I, A 8010 Graz, Austria
    J Biotechnol 158:192-202. 2012
  2. ncbi Furfural, 5-hydroxymethyl furfural, and acetoin act as external electron acceptors during anaerobic fermentation of xylose in recombinant Saccharomyces cerevisiae
    C Fredrik Wahlbom
    Department of Applied Microbiology, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Biotechnol Bioeng 78:172-8. 2002
  3. ncbi Xylitol does not inhibit xylose fermentation by engineered Saccharomyces cerevisiae expressing xylA as severely as it inhibits xylose isomerase reaction in vitro
    Suk Jin Ha
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, 61801, USA
    Appl Microbiol Biotechnol 92:77-84. 2011
  4. ncbi Efficient production of L-lactic acid from corncob molasses, a waste by-product in xylitol production, by a newly isolated xylose utilizing Bacillus sp. strain
    Limin Wang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People s Republic of China
    Bioresour Technol 101:7908-15. 2010
  5. ncbi Xylitol production by recombinant Corynebacterium glutamicum under oxygen deprivation
    Miho Sasaki
    Research Institute of Innovative Technology for the Earth, 9 2 Kizugawadai, Kizugawa, Kyoto, Japan
    Appl Microbiol Biotechnol 86:1057-66. 2010
  6. ncbi Isolation and characterization of xylitol-producing yeasts from the gut of colleopteran insects
    R Sreenivas Rao
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Curr Microbiol 55:441-6. 2007
  7. ncbi Improving ethanol and xylitol fermentation at elevated temperature through substitution of xylose reductase in Kluyveromyces marxianus
    Biao Zhang
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
    J Ind Microbiol Biotechnol 40:305-16. 2013
  8. pmc Decreased xylitol formation during xylose fermentation in Saccharomyces cerevisiae due to overexpression of water-forming NADH oxidase
    Guo Chang Zhang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
    Appl Environ Microbiol 78:1081-6. 2012
  9. ncbi Inhibitory action of toxic compounds present in lignocellulosic hydrolysates on xylose to xylitol bioconversion by Candida guilliermondii
    Rogério S Pereira
    Department of Biotechnology, Engineering College of Lorena, University of Sao Paulo, Estrada Municipal do Campinho s n, 12602 810, Lorena, SP, Brazil
    J Ind Microbiol Biotechnol 38:71-8. 2011
  10. ncbi Xylitol production by a Pichia stipitis D-xylulokinase mutant
    Yong Su Jin
    Department of Food Science, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Appl Microbiol Biotechnol 68:42-5. 2005

Detail Information

Publications278 found, 100 shown here

  1. pmc Analysis and prediction of the physiological effects of altered coenzyme specificity in xylose reductase and xylitol dehydrogenase during xylose fermentation by Saccharomyces cerevisiae
    Stefan Krahulec
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12 I, A 8010 Graz, Austria
    J Biotechnol 158:192-202. 2012
    ..The coenzyme specificities of the NADPH-preferring xylose reductase (XR) and the NAD⁺-dependent xylitol dehydrogenase (XDH) have been targeted in previous studies by protein design or evolution with the aim of ..
  2. ncbi Furfural, 5-hydroxymethyl furfural, and acetoin act as external electron acceptors during anaerobic fermentation of xylose in recombinant Saccharomyces cerevisiae
    C Fredrik Wahlbom
    Department of Applied Microbiology, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Biotechnol Bioeng 78:172-8. 2002
    ..Acetoin halted xylitol excretion and decreased the flux through the oxidative pentose phosphate pathway...
  3. ncbi Xylitol does not inhibit xylose fermentation by engineered Saccharomyces cerevisiae expressing xylA as severely as it inhibits xylose isomerase reaction in vitro
    Suk Jin Ha
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, 61801, USA
    Appl Microbiol Biotechnol 92:77-84. 2011
    ..31 g/g) under anaerobic conditions. Interestingly, significant amounts of xylitol (0...
  4. ncbi Efficient production of L-lactic acid from corncob molasses, a waste by-product in xylitol production, by a newly isolated xylose utilizing Bacillus sp. strain
    Limin Wang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People s Republic of China
    Bioresour Technol 101:7908-15. 2010
    ..containing a high content of xylose, which is one of the lignocellulosic biomasses and a waste by-product from xylitol production, was used for L-lactic acid production via a newly isolated xylose utilizing Bacillus sp. strain XZL9...
  5. ncbi Xylitol production by recombinant Corynebacterium glutamicum under oxygen deprivation
    Miho Sasaki
    Research Institute of Innovative Technology for the Earth, 9 2 Kizugawadai, Kizugawa, Kyoto, Japan
    Appl Microbiol Biotechnol 86:1057-66. 2010
    Wild-type Corynebacterium glutamicum produced 0.6 g l(-1) xylitol from xylose at a productivity of 0.01 g l(-1) h(-1) under oxygen deprivation. To increase this productivity, the pentose transporter gene (araE) from C...
  6. ncbi Isolation and characterization of xylitol-producing yeasts from the gut of colleopteran insects
    R Sreenivas Rao
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Curr Microbiol 55:441-6. 2007
    ..Twenty of these yeasts utilized xylose as a sole carbon source but only 12 of these converted xylose to xylitol. The ability to convert xylose to xylitol varied among the isolates and ranged from 0.12 to 0.58 g/g xylose...
  7. ncbi Improving ethanol and xylitol fermentation at elevated temperature through substitution of xylose reductase in Kluyveromyces marxianus
    Biao Zhang
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
    J Ind Microbiol Biotechnol 40:305-16. 2013
    ..The ability of the resultant recombinant strains to assimilate xylose to produce xylitol and ethanol at elevated temperature was greatly improved...
  8. pmc Decreased xylitol formation during xylose fermentation in Saccharomyces cerevisiae due to overexpression of water-forming NADH oxidase
    Guo Chang Zhang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
    Appl Environ Microbiol 78:1081-6. 2012
    The recombinant xylose-fermenting Saccharomyces cerevisiae strain harboring xylose reductase (XR) and xylitol dehydrogenase (XDH) from Scheffersomyces stipitis requires NADPH and NAD(+), creates cofactor imbalance, and causes xylitol ..
  9. ncbi Inhibitory action of toxic compounds present in lignocellulosic hydrolysates on xylose to xylitol bioconversion by Candida guilliermondii
    Rogério S Pereira
    Department of Biotechnology, Engineering College of Lorena, University of Sao Paulo, Estrada Municipal do Campinho s n, 12602 810, Lorena, SP, Brazil
    J Ind Microbiol Biotechnol 38:71-8. 2011
    ..of acetic acid, ferulic acid, and syringaldehyde on metabolism of Candida guilliermondii yeast during xylose to xylitol bioconversion was evaluated...
  10. ncbi Xylitol production by a Pichia stipitis D-xylulokinase mutant
    Yong Su Jin
    Department of Food Science, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Appl Microbiol Biotechnol 68:42-5. 2005
    b>Xylitol production by Pichia stipitis FPL-YS30, a xyl3-delta1 mutant that metabolizes xylose using an alternative metabolic pathway, was investigated under aerobic and oxygen-limited culture conditions...
  11. pmc Streptococcus mutans: fructose transport, xylitol resistance, and virulence
    J M Tanzer
    University of Connecticut, School of Dental Medicine, Farmington, CT 06030 1605, USA
    J Dent Res 85:369-73. 2006
    ..fruI is also responsible for xylitol transport. We hypothesized that fructose and xylitol transport systems do not affect virulence...
  12. ncbi Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study
    Joshua D Weissman
    Department of Otolaryngology Head and Neck Surgery, Stanford Hospital and Clinics, Stanford, California, USA
    Laryngoscope 121:2468-72. 2011
    To determine the tolerability of xylitol mixed with water as a nasal irrigant and to evaluate whether xylitol nasal irrigation results in symptomatic improvement of subjects with chronic rhinosinusitis.
  13. ncbi Adherence of Streptococcus pneumoniae to polystyrene plates and epithelial cells and the antiadhesive potential of albumin and xylitol
    Vicente Ruiz
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, 28040 Madrid, Spain
    Pediatr Res 69:23-7. 2011
    ..pneumococcal strains to polystyrene plates and on epithelial cells and the antiadhesive effect of albumin and xylitol. The adherence was variable among strains, but there was a good correlation between their adherent ability and ..
  14. ncbi Xylitol production from corn fiber and sugarcane bagasse hydrolysates by Candida tropicalis
    R Sreenivas Rao
    Department of Microbiology, Osmania University, Hyderabad, India
    Bioresour Technol 97:1974-8. 2006
    A natural isolate, Candida tropicalis was tested for xylitol production from corn fiber and sugarcane bagasse hydrolysates...
  15. ncbi Increase of xylitol production rate by controlling redox potential in Candida parapsilosis
    D K Oh
    Department of Food Science and Technology, Woosuk University, Cheonju 565 800, Korea
    Biotechnol Bioeng 58:440-4. 1998
    The effect of redox potential on xylitol production by Candida parapsilosis was investigated...
  16. ncbi Production of 2,3-butanediol from corncob molasses, a waste by-product in xylitol production
    Ailong Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 87:965-70. 2010
    Corncob molasses, a waste by-product in xylitol production, contains high concentrations of mixed sugars. In the present study, corncob molasses was used to produce 2,3-butanediol (BD) using Klebsiella pneumoniae SDM...
  17. ncbi Thirty-nine-month xylitol chewing-gum programme in initially 8-year-old school children: a feasibility study focusing on mutans streptococci and lactobacilli
    Kauko K Mäkinen
    Institute of Dentistry, University of Turku, Finland
    Int Dent J 58:41-50. 2008
    To investigate the use of xylitol-containing chewing-gums in public elementary schools as a means to affect the growth of salivary and plaque mutans streptococci and salivary lactobacilli.
  18. ncbi Effect of xylitol and fluoride on enamel erosion in vitro
    Siriwan Chunmuang
    Department of Prosthetic Dentistry, Faculty of Dentistry, Prince of Songkla University, Songkla, Thailand
    J Oral Sci 49:293-7. 2007
    This study aimed to determine the anti-erosive effects of xylitol, fluoride and a xylitol/fluoride combination used as an additive in an acidic drink or as mouthrinse after enamel was exposed to an acidic drink, in vitro...
  19. ncbi The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized clinical trial in an area of natural fluoridation
    Aija Maaria Hietala Lenkkeri
    Carea Joint Municipal Authority for Medical and Social Services in Kymenlaakso, Kuusankoski, Finland
    Int J Paediatr Dent 22:180-90. 2012
    b>Xylitol studies suggest caries reductions in the order of 50%. Based on animal/microbial studies, erythritol potentially has caries-preventive properties. However, clinical studies are required to confirm this...
  20. ncbi Xylitol production by Debaryomyces hansenii in brewery spent grain dilute-acid hydrolysate: effect of supplementation
    Florbela Carvalheiro
    Departamento de Biotecnologia, INETI, Estrada do Paco do Lumiar 22, Lisboa, 1649 038, Portugal
    Biotechnol Lett 29:1887-91. 2007
    A brewery spent-grain hemicellulosic hydrolysate was used for xylitol production by Debaryomyces hansenii. Addition of 6 g yeast extract/l increased the xylitol yield to 0.57 g/g, and productivity to 0.51 g/l h that were, respectively, 1...
  21. ncbi Xylitol production by genetically engineered Trichoderma reesei strains using barley straw as feedstock
    Mehdi Dashtban
    Biorefining Research Institute BRI, Lakehead University, 955 Oliver Road, Thunder Bay, ON, Canada P7E 5E1
    Appl Biochem Biotechnol 169:554-69. 2013
    b>Xylitol, a naturally occurring five-carbon sugar alcohol derived from D-xylose, is currently in high demand by industries...
  22. ncbi Repeated-batch xylitol bioproduction using yeast cells entrapped in polyvinyl alcohol-hydrogel
    M A A Cunha
    Department of Biotechnology, Faculty of Chemical Engineering, Lorena, Rodovia Itajubá Lorena, Km 74 5, C P 116, 12600 970, Lorena SP, Brazil
    Curr Microbiol 54:91-6. 2007
    Xylose-to-xylitol conversion was investigated in a bench-scale bioreactor using Candida guilliermondii cells entrapped within polyvinyl alcohol-hydrogel beads in a system operated in repeated-batch mode with cell recycling...
  23. ncbi Construction of a xylose-metabolizing yeast by genome integration of xylose isomerase gene and investigation of the effect of xylitol on fermentation
    Takanori Tanino
    Department of Chemical and Environmental Engineering, Gunma University, Kiryu, Japan
    Appl Microbiol Biotechnol 88:1215-21. 2010
    ..In addition, it was demonstrated that xylitol in the medium exhibits a concentration-dependent inhibition effect on the ethanol production from xylose with the ..
  24. ncbi Xylitol inhibits carcinogenic acetaldehyde production by Candida species
    Johanna Uittamo
    Research Unit on Acetaldehyde and Cancer, University of Helsinki, Helsinki, Finland
    Int J Cancer 129:2038-41. 2011
    ..The study hypothesis was that xylitol could reduce the amount of acetaldehyde produced by Candida...
  25. ncbi Effect of enhanced xylose reductase activity on xylose consumption and product distribution in xylose-fermenting recombinant Saccharomyces cerevisiae
    Marie Jeppsson
    Department of Applied Microbiology, Lund University, P O Box 124, 221 00 Lund, Sweden
    FEMS Yeast Res 3:167-75. 2003
    ..Saccharomyces cerevisiae TMB3001, harboring the Pichia stipitis genes XYL1 and XYL2 (xylose reductase and xylitol dehydrogenase, respectively) and the endogenous XKS1(xylulokinase), can convert xylose to ethanol...
  26. ncbi Effect of the reversal of coenzyme specificity by expression of mutated Pichia stipitis xylitol dehydrogenase in recombinant Saccharomyces cerevisiae
    J Hou
    The State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, China
    Lett Appl Microbiol 45:184-9. 2007
    To determine the effects on xylitol accumulation and ethanol yield of expression of mutated Pichia stipitis xylitol dehydrogenase (XDH) with reversal of coenzyme specificity in recombinant Saccharomyces cerevisiae.
  27. ncbi The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies
    Amol Deshpande
    Comprehensive Pain Program, University Health Network
    J Am Dent Assoc 139:1602-14. 2008
    ..The authors conducted a systematic review of original studies that was designed to assess the impact of polyol-containing chewing gum on dental caries compared with the effect with no chewing gum...
  28. ncbi Analysis of NADPH supply during xylitol production by engineered Escherichia coli
    Jonathan W Chin
    Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biotechnol Bioeng 102:209-20. 2009
    ..expressing an NADPH-dependent xylose reductase from Candida boidinii (CbXR) was previously reported to produce xylitol from xylose while metabolizing glucose [Cirino et al. (2006) Biotechnol Bioeng 95(6): 1167-1176]...
  29. ncbi Effect of acetic acid present in bagasse hydrolysate on the activities of xylose reductase and xylitol dehydrogenase in Candida guilliermondii
    Luanne Helena Augusto Lima
    Departamento de Biologia Celular, Universidade de Brasilia, 70910 900 Brasilia, DF, Brazil
    Appl Microbiol Biotechnol 65:734-8. 2004
    ..1.1.21) and NAD(P)-dependent xylitol dehydrogenase (XDH) (EC 1.1.1.9), which lead to xylose-->xylitol-->xylulose conversion...
  30. pmc Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsis
    Marjo Renko
    Department of Paediatrics, University of Oulu, Oulu, Finland
    BMC Microbiol 8:45. 2008
    b>Xylitol has antiadhesive effects on Streptococcus pneumoniae and inhibits its growth, and has also been found to be effective in preventing acute otitis media and has been used in intensive care as a valuable source of energy.
  31. ncbi Antisense inhibition of xylitol dehydrogenase gene, xdh1 from Trichoderma reesei
    T H Wang
    The State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, China
    Lett Appl Microbiol 40:424-9. 2005
    To inhibit xylitol dehydrogenase (XDH) in Trichoderma reesei by antisense inhibition strategy and construct novel strains capable of accumulating xylitol.
  32. ncbi A rare sugar xylitol. Part I: the biochemistry and biosynthesis of xylitol
    Tom Birger Granström
    Rare Sugar Research Center, Kagawa University, Miki cho, Kagawa, 761 0795, Japan
    Appl Microbiol Biotechnol 74:277-81. 2007
    The rare sugar xylitol is a five-carbon polyol (pentitol) that has beneficial health effects. Xylitol has global markets and, therefore, it represents an alternative to current dominant sweeteners...
  33. ncbi Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid
    D Storey
    Biomedical Science Research Institute, School of Environment and Life Sciences, The University of Salford, Salford, Greater Manchester, UK
    Eur J Clin Nutr 61:349-54. 2007
    To determine and compare the gastrointestinal (GI) responses of young adults following consumption of 45 g sucrose, 20, 35 and 50 g xylitol or erythritol given as a single oral, bolus dose in a liquid.
  34. pmc Microbial and bioconversion production of D-xylitol and its detection and application
    Xi Chen
    Biorefining Research Initiative and Department of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada
    Int J Biol Sci 6:834-44. 2010
    D-Xylitol is found in low content as a natural constituent of many fruits and vegetables...
  35. ncbi Cloning and functional characterization of LjPLT4, a plasma membrane xylitol H(+)- symporter from Lotus japonicus
    Katerina I Kalliampakou
    Laboratory of Molecular Biology, Department of Agricultural Biotechnology, Agricultural University of Athens, Athens, Greece
    Mol Membr Biol 28:1-13. 2011
    ..Transport assays revealed that LjPLT4 is a xylitol-specific H(+)-symporter (K (m), 0.34 mM)...
  36. ncbi Acceptance of the xylitol chewing gum regimen by preschool children and teachers in a Head Start program: a pilot study
    J T Autio
    Department of Operative Dentistry, University of Florida, Gainesville, Florida, USA
    Pediatr Dent 23:71-4. 2001
    This pilot study evaluated the acceptance and compliance of a xylitol chewing gum regimen by both children and classroom teachers in a Head Start program.
  37. ncbi Improved NADPH supply for xylitol production by engineered Escherichia coli with glycolytic mutations
    Jonathan W Chin
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Biotechnol Prog 27:333-41. 2011
    ..coli engineered to uptake xylose while metabolizing glucose was previously shown to produce high levels of xylitol from a mixture of glucose and xylose when expressing NADPH-dependent xylose reductase from Candida boidinii (CbXR)..
  38. ncbi Cariogenic traits in xylitol-resistant and xylitol-sensitive mutans streptococci
    S Assev
    Department of Oral Biology, The Faculty of Dentistry, University of Oslo, Oslo, Norway
    Oral Microbiol Immunol 17:95-9. 2002
    Long-term xylitol consumption leads to the emergence of xylitol-resistant (X-R) mutans streptococci. The aim of the present study was to compare cariogenic traits in X-R and xylitol-sensitive (X-S) strains...
  39. ncbi The effects of oral xylitol administration on bone density in rat femur
    Hirokazu Sato
    Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo, 102 8159, Japan
    Odontology 99:28-33. 2011
    To examine the effects of oral xylitol administration on rat femur bone density, 36 four-week-old male Wistar rats divided into three groups were fed CE-2 diet (control, n = 12) alone or supplemented with 10% (n = 12) or 20% (n = 12) ..
  40. ncbi Dynamic sieving capillary electrophoresis analysis of xylitol selenite-induced apoptosis in SMMC-7221 cells
    Ming Lei
    Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, No 152, Luoyu Road of Wuhan, Wuhan, Hubei Province, People s Republic of China
    Biotechnol Lett 34:1617-21. 2012
    ..Inter-nucleosomal DNA fragmentations induced by xylitol selenite were determined for the first time, while hydroxypropylmethylcellulose (HPMC) was served as the sieving ..
  41. ncbi Effect of xylitol and other carbon sources on Streptococcus pneumoniae biofilm formation and gene expression in vitro
    Paula Kurola
    National Institute for Health and Welfare, Oulu, Finland
    APMIS 119:135-42. 2011
    b>Xylitol inhibits the growth of Streptococcus pneumoniae. In clinical trials, xylitol decreased the occurrence of acute otitis media in day-care children, but did not decrease nasopharyngeal carriage of pneumococci...
  42. pmc Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol-xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum
    Sandra Scheele
    Institut für Bio und Geowissenschaften 1, Biotechnologie, Forschungszentrum Julich GmbH, Julich, Germany
    Microb Biotechnol 6:202-6. 2013
    ..glutamicum as the expression host, successful secretion of a normally cytosolic FAD cofactor-containing sorbitol-xylitol oxidase from Streptomyces coelicolor was achieved by using the twin-arginine translocation (Tat) protein export ..
  43. ncbi Xylitol production from a mutant strain of Candida tropicalis
    Y J Jeon
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Kensington, NSW, Australia
    Lett Appl Microbiol 53:106-13. 2011
    To characterize the kinetics of growth, sugar uptake and xylitol production in batch and fed-batch cultures for a xylitol assimilation-deficient strain of Candida tropicalis isolated via chemical mutagenesis.
  44. ncbi Kinetic modelling of the sequential production of lactic acid and xylitol from vine trimming wastes
    Carlos García-Diéguez
    Department of Chemical Engineering School of Engineering, USC, University of Santiago de Compostela, Rua Lope Gomez de Marzoa s n, 15782, Santiago de Compostela, Spain
    Bioprocess Biosyst Eng 34:869-78. 2011
    A mathematical model describing the kinetics of the sequential production of lactic acid and xylitol from detoxified-concentrated vine trimming hemicellulosic hydrolysates by Lactobacillus rhamnosus and Debaryomyces hansenii, ..
  45. ncbi Increased bone volume and bone mineral content in xylitol-fed aged rats
    P T Mattila
    Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland
    Gerontology 47:300-5. 2001
    Our previous studies have shown that dietary xylitol supplementation protects against the loss of bone mineral after ovariectomy. The ovariectomy-induced decrease in trabecular bone volume is significantly retarded by dietary xylitol.
  46. ncbi Improved bone biomechanical properties in xylitol-fed aged rats
    P T Mattila
    Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland
    Metabolism 51:92-6. 2002
    Our previous studies have shown that dietary xylitol protects against weakening of bone biomechanical properties in experimental postmenopausal osteoporosis...
  47. ncbi Effects of xylitol as a sugar substitute on diabetes-related parameters in nondiabetic rats
    Md Shahidul Islam
    Department of Biochemistry, School of Biochemistry, Genetics and Microbiology, University of KwaZulu Natal, Westville Campus, Durban, South Africa
    J Med Food 14:505-11. 2011
    Abstract The present study was examined the effects of xylitol feeding on diabetes-associated parameters in nondiabetic rats...
  48. ncbi Role of glycerol addition on xylose-to-xylitol bioconversion by Candida guilliermondii
    Priscila V Arruda
    Departamento de Biotecnologia, Escola de Engenharia de Lorena, Universidade de Sao Paulo, Estrada Municipal do Campinho s n, P O Box 116, Lorena, SP 12602 810, Brazil
    Curr Microbiol 58:274-8. 2009
    The effect of glycerol on xylose-to-xylitol bioconversion by Candida guilliermondii was evaluated by its addition (0.7 and 6.5 g/l) to semidefined media (xylose as a substrate)...
  49. ncbi Enhancement of xylitol production by attenuation of intracellular xylitol dehydrogenase activity in Candida tropicalis
    Byoung Sam Ko
    Higher Education Center for Bioregulator Research, Chonnam National University, Gwangju, 500 757, Korea
    Biotechnol Lett 33:1209-13. 2011
    To construct Candida tropicalis strains that produce a high yield of xylitol with no requirement for co-substrates, we engineered the yeast with an attenuated xylitol dehydrogenase (XDH) and then assessed the efficiency of xylitol ..
  50. ncbi Enhancement of xylitol production in Candida tropicalis by co-expression of two genes involved in pentose phosphate pathway
    Irshad Ahmad
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1, Guseong Dong, Yuseong Gu, Daejeon, 305 701, Korea
    Bioprocess Biosyst Eng 35:199-204. 2012
    The yeast Candida tropicalis produces xylitol, a natural, low-calorie sweetener whose metabolism does not require insulin, by catalytic activity of NADPH-dependent xylose reductase...
  51. pmc Safety assessment of inhaled xylitol in mice and healthy volunteers
    Lakshmi Durairaj
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Respir Res 5:13. 2004
    b>Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers.
  52. ncbi Xylitol, sweeteners, and dental caries
    Kiet A Ly
    Department of Dental Public Health Sciences, the Northwest Alaska Center to Reduce Oral Health Disparities, USA
    Pediatr Dent 28:154-63; discussion 192-8. 2006
    The purpose of this report was to provide an overview of xylitol and other polyol sweeteners and dental caries for clinicians and to discuss current applications for dental practice and potential community-based public health ..
  53. ncbi Production of xylitol from Candida tropicalis by using an oxidation-reduction potential-stat controlled fermentation
    Dey Chyi Sheu
    Department of Bioengineering, Tatung University, Taipei 104, Taiwan
    Biotechnol Lett 25:2065-9. 2003
    An on-line device, ORP (oxidation-reduction potential)-stat, was used to control glucose-feeding for enhancing xylitol conversion from D-xylose during an oxygen-limited fermentation by Candida tropicalis...
  54. ncbi Influence of a low xylitol-dose on mutans streptococci colonisation and caries development in preschool children
    P Oscarson
    Lycksele Public Dental Clinic, Umea, Sweden
    Eur Arch Paediatr Dent 7:142-7. 2006
    To evaluate the effect of xylitol-containing tablets on mutans streptococci colonisation and caries development in preschool children.
  55. ncbi Semi-continuous xylose-to-xylitol bioconversion by Ca-alginate entrapped yeast cells in a stirred tank reactor
    Walter Carvalho
    Departamento de Biotecnologia, Escola de Engenharia de Lorena, Estrada Municipal do Campinho s n, Lorena, SP, Brazil
    Bioprocess Biosyst Eng 31:493-8. 2008
    Candida guilliermondii FTI 20037 cells were entrapped in Ca-alginate beads and used for xylose-to-xylitol bioconversions during five successive batches in a stirred tank reactor...
  56. ncbi High expression of XYL2 coding for xylitol dehydrogenase is necessary for efficient xylose fermentation by engineered Saccharomyces cerevisiae
    Soo Rin Kim
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Metab Eng 14:336-43. 2012
    ..cerevisiae. However, the resulting engineered strains have been reported to exhibit large variations in xylitol accumulation and ethanol yields, generating many hypotheses and arguments for elucidating these phenomena...
  57. ncbi A rare sugar xylitol. Part II: biotechnological production and future applications of xylitol
    Tom Birger Granström
    Rare Sugar Research Center, Kagawa University, Miki cho, Kagawa, 761 0795, Japan
    Appl Microbiol Biotechnol 74:273-6. 2007
    b>Xylitol is the first rare sugar that has global markets. It has beneficial health properties and represents an alternative to current conventional sweeteners...
  58. ncbi Xylitol-resistant mutans streptococci strains and the frequency of xylitol consumption in young children
    Pia Meurman
    Institute of Dentistry, University of Turku, Finland
    Acta Odontol Scand 63:314-6. 2005
  59. pmc Production of xylitol from D-xylose by a xylitol dehydrogenase gene-disrupted mutant of Candida tropicalis
    Byoung Sam Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Appl Environ Microbiol 72:4207-13. 2006
    b>Xylitol dehydrogenase (XDH) is one of the key enzymes in d-xylose metabolism, catalyzing the oxidation of xylitol to d-xylulose...
  60. ncbi Improved ethanol and reduced xylitol production from glucose and xylose mixtures by the mutant strain of Candida shehatae ATCC 22984
    Yuan Li
    National Food Research Institute, National Agriculture and Food Research Organization, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Appl Biochem Biotechnol 166:1781-90. 2012
    ..4 g/l of ethanol from 121.3 g/l of xylose, which was 13% higher than that by ATCC 22984. At the same time, xylitol production was reduced by 38% to 10.2 g/l from 16.3 g/l by ATCC 22984...
  61. ncbi Effect of nutrient supplementation of crude or detoxified concentrated distilled grape marc hemicellulosic hydrolysates on the xylitol production by Debaryomyces hansenii
    José Manuel Salgado
    Department of Chemical Engineering, University of Vigo Campus Ourense, Spain
    Prep Biochem Biotechnol 42:1-14. 2012
    Biosynthesis of xylitol using the yeast Debaryomyces hansenii NRRL Y-7426 was carried out using distilled grape marc (DGM) hemicellulosic hydrolysates directly concentrated by vacuum evaporation or after detoxification with activated ..
  62. ncbi The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator
    H S Mäkeläinen
    Enteromix Research, Danisco Finland, Sokeritehtaantie 20, FIN 02460 Kantvik, Finland
    J Food Sci 72:M153-9. 2007
    This study focused on the effects of candidate prebiotics polydextrose (PDX) and xylitol on the microbial community and its metabolic activity in a colon simulator...
  63. ncbi A novel model to study bacterial adherence to the transplanted airway: inhibition of Burkholderia cepacia adherence to human airway by dextran and xylitol
    Umadevi Sajjan
    Division of Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:1382-91. 2004
    ..Because adherence to mucosal surfaces is an important initial step in infection, we investigated the use of non-toxic neutral polysaccharides and a sugar alcohol to prevent adherence of B cepacia complex to allograft airway epithelium...
  64. ncbi Salivary mutans streptococci and dental caries in three-year-old children after maternal exposure to chewing gums containing combinations of xylitol, sorbitol, chlorhexidine, and fluoride
    Ingrid Thorild
    Public Dental Clinic, Varberg, Sweden
    Acta Odontol Scand 62:245-50. 2004
    The aim of this study was to evaluate the effect of maternal use of chewing gums containing combinations of xylitol, sorbitol, chlorhexidine, and fluoride on salivary mutans streptococci (MS) counts and caries prevalence in the mothers' ..
  65. pmc Raman spectroscopy of xylitol uptake and metabolism in Gram-positive and Gram-negative bacteria
    SUNIL PALCHAUDHURI
    School of Medicine, Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA
    Appl Environ Microbiol 77:131-7. 2011
    ..Raman spectroscopy was used to investigate the uptake and metabolism of the five-carbon sugar alcohol xylitol by Gram-positive viridans group streptococcus and the two extensively used strains of Gram-negative Escherichia ..
  66. pmc Anaerobic obligatory xylitol production in Escherichia coli strains devoid of native fermentation pathways
    Olubolaji Akinterinwa
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Appl Environ Microbiol 77:706-9. 2011
    ..b>Xylitol production serves as the primary means of NAD(P)(+) regeneration, as glucose is converted primarily to acetate ..
  67. ncbi The effect of chlorhexidine acetate/xylitol chewing gum on the plaque and gingival indices of elderly occupants in residential homes
    D Simons
    Dental Caries Research Group, Guy's, King's and St Thomas's Dental Institute, London, UK
    J Clin Periodontol 28:1010-5. 2001
    ..controlled, double-blind, clinical trial was conducted to investigate the effect of a chlorhexidine acetate/xylitol gum (ACHX) on the plaque and gingival indices of 111 elderly occupants in residential homes...
  68. ncbi Ethanol and xylitol production from glucose and xylose at high temperature by Kluyveromyces sp. IIPE453
    Sachin Kumar
    Biotechnology Area, Indian Institute of Petroleum, Dehradun, India
    J Ind Microbiol Biotechnol 36:1483-9. 2009
    ..The strain also showed xylitol production from xylose. In batch fermentation, the strain showed maximum ethanol concentration of 82 +/- 0...
  69. ncbi Development of a yeast strain for xylitol production without hydrolysate detoxification as part of the integration of co-product generation within the lignocellulosic ethanol process
    Chiung Fang Huang
    Cellulosic ethanol project, Institute of Nuclear Energy Research, Taoyuan County, Taiwan, ROC
    Bioresour Technol 102:3322-9. 2011
    The present study verified an applicable technology of xylitol bioconversion as part of the integration of co-product generation within second-generation bioethanol processes...
  70. ncbi Integrated production of xylitol and ethanol using corncob
    Ke Ke Cheng
    Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing, 100084, People s Republic of China
    Appl Microbiol Biotechnol 87:411-7. 2010
    b>Xylitol production from corncob hemicellulose is a popular process in China. Microbial conversion of xylose to xylitol, as a biological process with many advantages, has drawn increasing attention...
  71. ncbi Microbial production of xylitol from D-xylose and sugarcane bagasse hemicellulose using newly isolated thermotolerant yeast Debaryomyces hansenii
    Gyan Prakash
    Biochemical Sciences Division, National Chemical Laboratory, Pune, India
    Bioresour Technol 102:3304-8. 2011
    A thermotolerant yeast capable of fermenting xylose to xylitol at 40°C was isolated and identified as a strain of Debaryomyces hansenii by ITS sequencing...
  72. ncbi Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars
    Nikhil U Nair
    Department of Chemical and Biomolecular Engineering, Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Metab Eng 12:462-8. 2010
    The biocatalytic reduction of D-xylose to xylitol requires separation of the substrate from L-arabinose, another major component of hemicellulosic hydrolysate...
  73. ncbi Xylitol production from DEO hydrolysate of corn stover by Pichia stipitis YS-30
    Rita C L B Rodrigues
    Departamento de Biotecnologia, DEBIQ, Escola de Engenharia de Lorena, EEL, USP, Universidade de Sao Paulo, P O Box 116, Lorena, SP 12600 970, Brazil
    J Ind Microbiol Biotechnol 38:1649-55. 2011
    ..a D-xylulokinase mutant of Pichia stipitis, FPL-YS30 (xyl3-∆1), converted the stover hydrolysate into xylitol. This research examined the effects of phosphoric or gluconic acids used for neutralization and urea or ammonium ..
  74. ncbi Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats
    Govindasamy Chandramohan
    Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, P O Box 10219, Riyadh 11433, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 24:95-101. 2010
    ..An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented...
  75. ncbi In vitro testing of xylitol as an anticariogenic agent
    Paul S Sahni
    Indiana University, Indianapolis, USA
    Gen Dent 50:340-3. 2002
    A number of studies involving xylitol chewing gum have demonstrated that xylitol is both noncariogenic and anticariogenic...
  76. ncbi Optimization of acid hydrolysis of sugarcane bagasse and investigations on its fermentability for the production of xylitol by Candida guilliermondii
    Rafael Fogel
    Departamento de Engenharia Bioquímica, Escola de Química CT, Universidade Federal do Rio de Janeiro, RJ, CEP 21949 900, Brazil
    Appl Biochem Biotechnol 121:741-52. 2005
    ..conversion (tC) to 75 h (without nitrogen source addition tC > 127 h), and, consequently, improving the rates of xylitol bioproduction...
  77. ncbi Effect of xylitol-containing chewing gums on interdental plaque-pH in habitual xylitol consumers
    Pernilla Lif Holgerson
    Department of Odontology, Pediatric Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
    Acta Odontol Scand 63:233-8. 2005
    The aim was to investigate the effect of high and low amounts of xylitol on the interdental plaque-pH, directly and after sucrose challenge, in schoolchildren with habitual consumption.
  78. ncbi Role of xylose transporters in xylitol production from engineered Escherichia coli
    Reza Khankal
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    J Biotechnol 134:246-52. 2008
    ..2006 [Cirino, P.C., Chin, J.W., Ingram, L.O., 2006. Engineering Escherichia coli for xylitol production from glucose-xylose mixtures. Biotechnol. Bioeng. 95, 1167-1176.])...
  79. ncbi Tyr-51 is the proton donor-acceptor for NAD(H)-dependent interconversion of xylose and xylitol by Candida tenuis xylose reductase (AKR2B5)
    Simone L Pival
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, A 8010 Graz, Austria
    FEBS Lett 582:4095-9. 2008
    ..bromide brought about unidirectional rate enhancement ( approximately 2x10(3)-fold at 300mM) for NAD(+)-dependent xylitol oxidation by Y51A...
  80. ncbi Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli
    E Caglar
    Department of Paediatric Dentistry, School of Dentistry, Yeditepe University, Bagdat cad 238, Goztepe, 34728 Istanbul, Turkey
    Clin Oral Investig 11:425-9. 2007
    The aim was to evaluate the effect of xylitol and probiotic chewing gums on salivary mutans streptococci (MS) and lactobacilli (LB). The material consisted of 80 healthy young adults (21-24 years) who volunteered after informed consent...
  81. ncbi Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants
    E Soderling
    Institute of Dentistry, University of Turku, Finland
    J Dent Res 79:882-7. 2000
    b>Xylitol is effective as a non-cariogenic sugar substitute. Habitual xylitol consumption appears to select for mutans streptococci (MS) with impaired adhesion properties, i.e., they shed easily to saliva from plaque...
  82. pmc Xylitol production from xylose mother liquor: a novel strategy that combines the use of recombinant Bacillus subtilis and Candida maltosa
    Hairong Cheng
    Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China
    Microb Cell Fact 10:5. 2011
    ..In China, more than 50,000 metric tons of xylose mother liquor was produced in 2009, and the management of sugars like xylose that present in the low-cost liquor is a problem...
  83. ncbi Optimization of fed-batch fermentation for xylitol production by Candida tropicalis
    J H Kim
    Department of Food Science and Technology, Research Center for New Bio Materials in Agriculture, Seoul National University, Suwon 441 744, South Korea
    J Ind Microbiol Biotechnol 29:16-9. 2002
    b>Xylitol, a functional sweetener, was produced from xylose by biological conversion using Candida tropicalis ATCC 13803...
  84. ncbi A model of xylitol production by the yeast Candida mogii
    Worasit Tochampa
    Department of Biotechnology, Kasetsart University, Bangkok, 10900 Thailand
    Bioprocess Biosyst Eng 28:175-83. 2005
    Production of xylitol from xylose in batch fermentations of Candida mogii ATCC 18364 is discussed in the presence of glucose as the cosubstrate...
  85. ncbi Xylitol for messrooms--a method worth trying to prevent caries among seafarers
    U Saarni
    Finnish Student Health Service, Turku, Finland
    Bull Inst Marit Trop Med Gdynia 48:91-7. 1997
    ..A newer method to prevent caries is systematic use of xylitol. Scientific evidence shows that the addition of small quantities of xylitol, a natural carbohydrate sweetener, to ..
  86. ncbi Microbiological purification of L-arabitol from xylitol mother liquor
    Mingguo Jiang
    College of Chemical Engineering and Ecology, Guangxi University for Nationality, Nanning, 530007, China
    J Microbiol Biotechnol 21:43-9. 2011
    ..Therefore, this study describes a novel L-arabitol production method based on biological purification from the xylitol mother liquor, a cheap and readily available raw material that contains a high concentration of Larabitol...
  87. pmc Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis
    Jung Kul Lee
    BioNgene Co, Ltd, Jongro Ku, Seoul 110 521, Korea
    Appl Environ Microbiol 69:6179-88. 2003
    Xylose reductase (XR) is a key enzyme in D-xylose metabolism, catalyzing the reduction of D-xylose to xylitol. An NADH-preferring XR was purified to homogeneity from Candida parapsilosis KFCC-10875, and the xyl1 gene encoding a 324-amino-..
  88. ncbi Improvement of xylitol production by Candida guilliermondii FTI 20037 previously adapted to rice straw hemicellulosic hydrolysate
    C J Silva
    Department of Biotechnology/FAENQUIL, , Lorena-SP, Brazil
    Lett Appl Microbiol 32:248-52. 2001
    AIMS: To evaluate a simple and economical technique to improve xylitol production using concentrated xylose solutions prepared from rice straw hemicellulosic hydrolysate...
  89. ncbi Enhancement of xylitol productivity and yield using a xylitol dehydrogenase gene-disrupted mutant of Candida tropicalis under fully aerobic conditions
    Byoung Sam Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon, 305 701, Republic of Korea
    Biotechnol Lett 28:1159-62. 2006
    The effects of glycerol and the oxygen transfer rate on the xylitol production rate by a xylitol dehydrogenase gene (XYL2)-disrupted mutant of Candida tropicalis were investigated...
  90. ncbi Xylitol gum and maternal transmission of mutans streptococci
    Y Nakai
    Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama Shi, Okayama 700 8525, Japan
    J Dent Res 89:56-60. 2010
    ..This study confirmed the effectiveness of maternal early exposure to xylitol chewing gum on mother-child transmission of MS...
  91. ncbi Evaluation of the dental plaque pH recovery effect of a xylitol lozenge on patients with fixed orthodontic appliances
    Abdulkadir Sengun
    Department of Conservative Dentistry, Faculty of Dentistry, Selcuk University, Campus Konya, Turkey
    Angle Orthod 74:240-4. 2004
    The purpose of this study was to evaluate the influence of a xylitol lozenge on the dental plaque pH profile of fixed orthodontic patients. Twelve volunteers participated in this study...
  92. ncbi Difference in the xylitol sensitivity of acid production among Streptococcus mutans strains and the biochemical mechanism
    H Miyasawa-Hori
    Division of Oral Ecology and Biochemistry, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Oral Microbiol Immunol 21:201-5. 2006
    b>Xylitol inhibits the glycolysis and growth of Streptococcus mutans, but to different degrees among strains. Thus, we studied the biochemical mechanism through which the inhibition varies, using S...
  93. ncbi Increase of xylitol productivity by cell-recycle fermentation of Candida tropicalis using submerged membrane bioreactor
    Soun Gyu Kwon
    Department of Bioscience and Biotechnology, Sejong University, 98 Gunja Dong, Gwangin gu, Seoul 143 747, Korea
    J Biosci Bioeng 101:13-8. 2006
    Candida tropicalis, an osmophilic strain isolated from honeycomb, produced xylitol at a maximal volumetric productivity of 3.5 g l(-1) h(-1) from an initial xylose concentration of 200 g l(-1). Even at a very high xylose concentration, e...
  94. pmc Cloning and expression of a xylitol-4-dehydrogenase gene from Pantoea ananatis
    J S Aarnikunnas
    Division of Microbiology and Epidemiology, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Appl Environ Microbiol 72:368-77. 2006
    The Pantoea ananatis ATCC 43072 mutant strain is capable of growing with xylitol as the sole carbon source...
  95. ncbi Lipase-catalyzed synthesis of xylitol monoesters: solvent engineering approach
    E Castillo
    Departamento de Bioingeniería, Instituto de Biotecnologia, UNAM, Apartado Postal 510 3, Cuernavaca, Morelos 62271, Mexico
    J Biotechnol 102:251-9. 2003
    A solvent engineering strategy was applied to the lipase-catalyzed synthesis of xylitol-oleic acid monoesters. The different esterification degrees for this polyhydroxylated molecule were examined in different organic solvent mixtures...
  96. ncbi Cloning of the xylitol dehydrogenase gene from Gluconobacter oxydans and improved production of xylitol from D-arabitol
    Masakazu Sugiyama
    AminoScience Laboratories, Ajinomoto Co, Inc, Suzuki cho, Kawasaki ku, Kawasaki shi 210 8681, Japan
    Biosci Biotechnol Biochem 67:584-91. 2003
    b>Xylitol dehydrogenase (XDH) was purified from the cytoplasmic fraction of Gluconobacter oxydans ATCC 621. The purified enzyme reduced D-xylulose to xylitol in the presence of NADH with an optimum pH of around 5.0...
  97. ncbi Xylitol enhances bacterial killing in the rabbit maxillary sinus
    Christopher L Brown
    Department of Otolaryngology Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242 1093, USA
    Laryngoscope 114:2021-4. 2004
    Factors that alter airway surface liquid (ASL) ionic concentrations may influence the course of sinusitis. Xylitol has been shown to effect ASL ionic composition in vitro and to reduce nasal bacterial carriage, otitis media, and dental ..
  98. ncbi Effect of xylitol on mutans streptococci and lactic acid formation in saliva and plaque from adolescents and young adults with fixed orthodontic appliances
    Christina Stecksén-Blicks
    Department of Odontology, Pediatric Dentistry, Umea University, Umea, Sweden
    Eur J Oral Sci 112:244-8. 2004
    This study aimed to investigate two dose regimens of xylitol-containing tablets on the ecology of dental plaque and saliva during treatment with fixed orthodontic appliances. The study group comprised 56 healthy patients (mean age 15...
  99. ncbi Engineering of a matched pair of xylose reductase and xylitol dehydrogenase for xylose fermentation by Saccharomyces cerevisiae
    Stefan Krahulec
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Austria
    Biotechnol J 4:684-94. 2009
    ..of nicotinamide adenine dinucleotide (phosphate) NAD(P)H-dependent xylose reductase (XR) and NAD(+)-dependent xylitol dehydrogenase (XDH)...
  100. pmc D-xylose metabolism in Hypocrea jecorina: loss of the xylitol dehydrogenase step can be partially compensated for by lad1-encoded L-arabinitol-4-dehydrogenase
    Bernhard Seiboth
    Abteilung für Angewandte Biochemie und Gentechnologie, Institut fur Verfahrenstechnik, Umwelttechnik, und Technische Biowissenschaften, A 1060 Wien, Austria
    Eukaryot Cell 2:867-75. 2003
    ..the D-xylose pathway in Hypocrea jecorina (anamorph: Trichoderma reesei), we cloned the xdh1 gene, encoding NAD-xylitol dehydrogenase, which catalyzes the second step of fungal D-xylose catabolism...
  101. ncbi Influence of maternal xylitol consumption on mother-child transmission of mutans streptococci: 6-year follow-up
    E Soderling
    Institute of Dentistry, University of Turku, Finland
    Caries Res 35:173-7. 2001
    b>Xylitol is effective as a noncariogenic or even cariostatic sugar substitute. Habitual xylitol consumption appears to select for mutans streptococci (MS) which shed easily into saliva from plaque...

Research Grants28

  1. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..b>Xylitol, a 5-carbon sugar, can lower ASL salt concentration without providing a carbon-source for bacteria...
  2. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    Gregg H Gilbert; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  3. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel A Shugars; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  4. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    WILLIAM MARION VOLLMER; Fiscal Year: 2011
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  5. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Tochukwu Amaechi; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  6. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James D Bader; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  7. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2004
    ..young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the ..
  8. Xylitol syrup for the prevention of acute otitis media in otitis-prone children
    Louis Vernacchio; Fiscal Year: 2010
    ..Challenge Topic 04-DC-101: Prevention of Otitis Media, we propose a clinical trial of a preparation of viscous xylitol with a mucosal adherence agent for the prevention of acute otitis media (AOM) in otitis-prone children...
  9. Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo
    CHIFU HUANG; Fiscal Year: 2006
    ..g. phenylketonurics and diabetics). Moreover, altered sugar alcohol substitute sweeteners, i.e. sorbitol, xylitol, that have been marketed as noncariogenic sweeteners, and more recently as sweeteners for low carbohydrate diets, ..
  10. Aerosolized xylitol for ventilator-associated pneumonia
    Lakshmi Durairaj; Fiscal Year: 2009
    ..The focus of this proposal is to study the effectiveness of a new intervention namely xylitol, a 5-carbon sugar, for the prevention of ventilator-associated pneumonia, a common nosocomial infection among ..
  11. SCOR in Airway Biology and Pathogenesis of Cystic Fibrosis
    Michael Welsh; Fiscal Year: 2007
    ..the compelling hypothesis that reducing ASL salt concentrations in vivo, by administering the non-ionic osmolyte xylitol will prevent or slow the progression of CF airway disease...
  12. Biotech & Materials Research to Reduce Caries Disparity
    Peter Milgrom; Fiscal Year: 2005
    ..The conference will be co-sponsored by the Northwest/Alaska Center to Reduce Oral Health Disparities, the University of Washington UWeb Bioengineering Center, and the Salivary Diagnostics Project. ..
  13. Fluoride Varnish to Prevent Caries in Toddlers - An Expanded Immunization Program
    Peter Milgrom; Fiscal Year: 2008
    ..Keywords: fluoride varnish, dental caries, oral health, early prevention, multi-center, toddlers. [unreadable] [unreadable] [unreadable]..
  14. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2005
    ..The intervention is the daily use of xylitol lozenges...
  15. XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXIS
    Louis Vernacchio; Fiscal Year: 2003
    ..b>Xylitol, a naturally occurring sugar alcohol, has been proposed as a prophylactic therapy for AOM...
  16. A STANDARD STRUCTURE AND FUNCTION FOR WD REPEAT PROTEINS
    David Wilson; Fiscal Year: 2005
    ..abstract_text> ..
  17. CHC Research Network to Address Oral Health Dispartities
    KIET LY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. STRUCTURE AND FUNCTION OF MITOTIC CHECKPOINT PROTEINS
    David Wilson; Fiscal Year: 2002
    ..This structure will provide an understanding of the effects of any cancer-causing mutations. It will later be used to analyze interactions with other human mitotic checkpoint control proteins. ..
  19. NATURAL PRODUCT SYNTHESIS THROUGH TEMPLATE DIRECTED C-H
    DUNCAN WARDROP; Fiscal Year: 2003
    ..abstract_text> ..
  20. Scientific Advances in CAM by Allied Health and Nursing
    Riva Touger Decker; Fiscal Year: 2003
    ..Intended outcomes of the annual conferences include electronically published proceedings, new and collaborative research and CAM research agendas and priorities for allied health and nursing that can be shared with the key associations. ..
  21. Predicting Caries Risk in Underserved Toddlers
    Margherita Fontana; Fiscal Year: 2005
    ....
  22. Synthesis through N-Acylnitrenium Ion Cyclization
    DUNCAN WARDROP; Fiscal Year: 2006
    ..abstract_text> ..
  23. Effectiveness of Sealing Caries: A Way to Reduce Disparities in Dental Caries
    Margherita Fontana; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. CONFOCAL MICROSCOPE
    Mark Ackermann; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Preterm birth, lung innate immunity, and RSV
    Mark Ackermann; Fiscal Year: 2009
    ..The work is significant because it discovers the underlying basis for RSV susceptibility preterm and mechanistic approaches to enhance innate immunity. ..
  26. Ligand-Receptor Segregation and Airway Remodeling
    Joseph Zabner; Fiscal Year: 2007
    ..We hypothesize that in the asthmatic airways, alterations in the epithelial barrier play a central role in airway epithelial remodeling. ..