xylitol

Summary

Summary: A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.

Top Publications

  1. ncbi Production of 2,3-butanediol from corncob molasses, a waste by-product in xylitol production
    Ailong Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 87:965-70. 2010
  2. ncbi Cariogenic traits in xylitol-resistant and xylitol-sensitive mutans streptococci
    S Assev
    Department of Oral Biology, The Faculty of Dentistry, University of Oslo, Oslo, Norway
    Oral Microbiol Immunol 17:95-9. 2002
  3. pmc Streptococcus mutans: fructose transport, xylitol resistance, and virulence
    J M Tanzer
    University of Connecticut, School of Dental Medicine, Farmington, CT 06030 1605, USA
    J Dent Res 85:369-73. 2006
  4. pmc Analysis and prediction of the physiological effects of altered coenzyme specificity in xylose reductase and xylitol dehydrogenase during xylose fermentation by Saccharomyces cerevisiae
    Stefan Krahulec
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12 I, A 8010 Graz, Austria
    J Biotechnol 158:192-202. 2012
  5. doi Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study
    Joshua D Weissman
    Department of Otolaryngology Head and Neck Surgery, Stanford Hospital and Clinics, Stanford, California, USA
    Laryngoscope 121:2468-72. 2011
  6. doi Improved NADPH supply for xylitol production by engineered Escherichia coli with glycolytic mutations
    Jonathan W Chin
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Biotechnol Prog 27:333-41. 2011
  7. ncbi Influence of maternal xylitol consumption on mother-child transmission of mutans streptococci: 6-year follow-up
    E Soderling
    Institute of Dentistry, University of Turku, Finland
    Caries Res 35:173-7. 2001
  8. doi Inhibitory action of toxic compounds present in lignocellulosic hydrolysates on xylose to xylitol bioconversion by Candida guilliermondii
    Rogério S Pereira
    Department of Biotechnology, Engineering College of Lorena, University of Sao Paulo, Estrada Municipal do Campinho s n, 12602 810, Lorena, SP, Brazil
    J Ind Microbiol Biotechnol 38:71-8. 2011
  9. doi Adherence of Streptococcus pneumoniae to polystyrene plates and epithelial cells and the antiadhesive potential of albumin and xylitol
    Vicente Ruiz
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, 28040 Madrid, Spain
    Pediatr Res 69:23-7. 2011
  10. ncbi Xylitol production by a Pichia stipitis D-xylulokinase mutant
    Yong Su Jin
    Department of Food Science, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Appl Microbiol Biotechnol 68:42-5. 2005

Detail Information

Publications253 found, 100 shown here

  1. ncbi Production of 2,3-butanediol from corncob molasses, a waste by-product in xylitol production
    Ailong Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 87:965-70. 2010
    Corncob molasses, a waste by-product in xylitol production, contains high concentrations of mixed sugars. In the present study, corncob molasses was used to produce 2,3-butanediol (BD) using Klebsiella pneumoniae SDM...
  2. ncbi Cariogenic traits in xylitol-resistant and xylitol-sensitive mutans streptococci
    S Assev
    Department of Oral Biology, The Faculty of Dentistry, University of Oslo, Oslo, Norway
    Oral Microbiol Immunol 17:95-9. 2002
    Long-term xylitol consumption leads to the emergence of xylitol-resistant (X-R) mutans streptococci. The aim of the present study was to compare cariogenic traits in X-R and xylitol-sensitive (X-S) strains...
  3. pmc Streptococcus mutans: fructose transport, xylitol resistance, and virulence
    J M Tanzer
    University of Connecticut, School of Dental Medicine, Farmington, CT 06030 1605, USA
    J Dent Res 85:369-73. 2006
    ..fruI is also responsible for xylitol transport. We hypothesized that fructose and xylitol transport systems do not affect virulence...
  4. pmc Analysis and prediction of the physiological effects of altered coenzyme specificity in xylose reductase and xylitol dehydrogenase during xylose fermentation by Saccharomyces cerevisiae
    Stefan Krahulec
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12 I, A 8010 Graz, Austria
    J Biotechnol 158:192-202. 2012
    ..The coenzyme specificities of the NADPH-preferring xylose reductase (XR) and the NAD⁺-dependent xylitol dehydrogenase (XDH) have been targeted in previous studies by protein design or evolution with the aim of ..
  5. doi Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study
    Joshua D Weissman
    Department of Otolaryngology Head and Neck Surgery, Stanford Hospital and Clinics, Stanford, California, USA
    Laryngoscope 121:2468-72. 2011
    To determine the tolerability of xylitol mixed with water as a nasal irrigant and to evaluate whether xylitol nasal irrigation results in symptomatic improvement of subjects with chronic rhinosinusitis.
  6. doi Improved NADPH supply for xylitol production by engineered Escherichia coli with glycolytic mutations
    Jonathan W Chin
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Biotechnol Prog 27:333-41. 2011
    ..coli engineered to uptake xylose while metabolizing glucose was previously shown to produce high levels of xylitol from a mixture of glucose and xylose when expressing NADPH-dependent xylose reductase from Candida boidinii (CbXR)..
  7. ncbi Influence of maternal xylitol consumption on mother-child transmission of mutans streptococci: 6-year follow-up
    E Soderling
    Institute of Dentistry, University of Turku, Finland
    Caries Res 35:173-7. 2001
    b>Xylitol is effective as a noncariogenic or even cariostatic sugar substitute. Habitual xylitol consumption appears to select for mutans streptococci (MS) which shed easily into saliva from plaque...
  8. doi Inhibitory action of toxic compounds present in lignocellulosic hydrolysates on xylose to xylitol bioconversion by Candida guilliermondii
    Rogério S Pereira
    Department of Biotechnology, Engineering College of Lorena, University of Sao Paulo, Estrada Municipal do Campinho s n, 12602 810, Lorena, SP, Brazil
    J Ind Microbiol Biotechnol 38:71-8. 2011
    ..of acetic acid, ferulic acid, and syringaldehyde on metabolism of Candida guilliermondii yeast during xylose to xylitol bioconversion was evaluated...
  9. doi Adherence of Streptococcus pneumoniae to polystyrene plates and epithelial cells and the antiadhesive potential of albumin and xylitol
    Vicente Ruiz
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, 28040 Madrid, Spain
    Pediatr Res 69:23-7. 2011
    ..pneumococcal strains to polystyrene plates and on epithelial cells and the antiadhesive effect of albumin and xylitol. The adherence was variable among strains, but there was a good correlation between their adherent ability and ..
  10. ncbi Xylitol production by a Pichia stipitis D-xylulokinase mutant
    Yong Su Jin
    Department of Food Science, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Appl Microbiol Biotechnol 68:42-5. 2005
    b>Xylitol production by Pichia stipitis FPL-YS30, a xyl3-delta1 mutant that metabolizes xylose using an alternative metabolic pathway, was investigated under aerobic and oxygen-limited culture conditions...
  11. ncbi Increase of xylitol production rate by controlling redox potential in Candida parapsilosis
    D K Oh
    Department of Food Science and Technology, Woosuk University, Cheonju 565 800, Korea
    Biotechnol Bioeng 58:440-4. 1998
    The effect of redox potential on xylitol production by Candida parapsilosis was investigated...
  12. ncbi Xylitol production from corn fiber and sugarcane bagasse hydrolysates by Candida tropicalis
    R Sreenivas Rao
    Department of Microbiology, Osmania University, Hyderabad, India
    Bioresour Technol 97:1974-8. 2006
    A natural isolate, Candida tropicalis was tested for xylitol production from corn fiber and sugarcane bagasse hydrolysates...
  13. doi Engineering of a matched pair of xylose reductase and xylitol dehydrogenase for xylose fermentation by Saccharomyces cerevisiae
    Stefan Krahulec
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Austria
    Biotechnol J 4:684-94. 2009
    ..of nicotinamide adenine dinucleotide (phosphate) NAD(P)H-dependent xylose reductase (XR) and NAD(+)-dependent xylitol dehydrogenase (XDH)...
  14. ncbi Effect of xylitol and fluoride on enamel erosion in vitro
    Siriwan Chunmuang
    Department of Prosthetic Dentistry, Faculty of Dentistry, Prince of Songkla University, Songkla, Thailand
    J Oral Sci 49:293-7. 2007
    This study aimed to determine the anti-erosive effects of xylitol, fluoride and a xylitol/fluoride combination used as an additive in an acidic drink or as mouthrinse after enamel was exposed to an acidic drink, in vitro...
  15. ncbi Thirty-nine-month xylitol chewing-gum programme in initially 8-year-old school children: a feasibility study focusing on mutans streptococci and lactobacilli
    Kauko K Mäkinen
    Institute of Dentistry, University of Turku, Finland
    Int Dent J 58:41-50. 2008
    To investigate the use of xylitol-containing chewing-gums in public elementary schools as a means to affect the growth of salivary and plaque mutans streptococci and salivary lactobacilli.
  16. doi Analysis of NADPH supply during xylitol production by engineered Escherichia coli
    Jonathan W Chin
    Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biotechnol Bioeng 102:209-20. 2009
    ..expressing an NADPH-dependent xylose reductase from Candida boidinii (CbXR) was previously reported to produce xylitol from xylose while metabolizing glucose [Cirino et al. (2006) Biotechnol Bioeng 95(6): 1167-1176]...
  17. doi Microbial production of xylitol from D-xylose and sugarcane bagasse hemicellulose using newly isolated thermotolerant yeast Debaryomyces hansenii
    Gyan Prakash
    Biochemical Sciences Division, National Chemical Laboratory, Pune, India
    Bioresour Technol 102:3304-8. 2011
    A thermotolerant yeast capable of fermenting xylose to xylitol at 40°C was isolated and identified as a strain of Debaryomyces hansenii by ITS sequencing...
  18. pmc Raman spectroscopy of xylitol uptake and metabolism in Gram-positive and Gram-negative bacteria
    SUNIL PALCHAUDHURI
    School of Medicine, Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA
    Appl Environ Microbiol 77:131-7. 2011
    ..Raman spectroscopy was used to investigate the uptake and metabolism of the five-carbon sugar alcohol xylitol by Gram-positive viridans group streptococcus and the two extensively used strains of Gram-negative Escherichia ..
  19. ncbi A novel model to study bacterial adherence to the transplanted airway: inhibition of Burkholderia cepacia adherence to human airway by dextran and xylitol
    Umadevi Sajjan
    Division of Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:1382-91. 2004
    ..Because adherence to mucosal surfaces is an important initial step in infection, we investigated the use of non-toxic neutral polysaccharides and a sugar alcohol to prevent adherence of B cepacia complex to allograft airway epithelium...
  20. ncbi The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator
    H S Mäkeläinen
    Enteromix Research, Danisco Finland, Sokeritehtaantie 20, FIN 02460 Kantvik, Finland
    J Food Sci 72:M153-9. 2007
    This study focused on the effects of candidate prebiotics polydextrose (PDX) and xylitol on the microbial community and its metabolic activity in a colon simulator...
  21. ncbi Integrated production of xylitol and ethanol using corncob
    Ke Ke Cheng
    Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing, 100084, People s Republic of China
    Appl Microbiol Biotechnol 87:411-7. 2010
    b>Xylitol production from corncob hemicellulose is a popular process in China. Microbial conversion of xylose to xylitol, as a biological process with many advantages, has drawn increasing attention...
  22. pmc Safety assessment of inhaled xylitol in mice and healthy volunteers
    Lakshmi Durairaj
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Respir Res 5:13. 2004
    b>Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers.
  23. ncbi Salivary mutans streptococci and dental caries in three-year-old children after maternal exposure to chewing gums containing combinations of xylitol, sorbitol, chlorhexidine, and fluoride
    Ingrid Thorild
    Public Dental Clinic, Varberg, Sweden
    Acta Odontol Scand 62:245-50. 2004
    The aim of this study was to evaluate the effect of maternal use of chewing gums containing combinations of xylitol, sorbitol, chlorhexidine, and fluoride on salivary mutans streptococci (MS) counts and caries prevalence in the mothers' ..
  24. ncbi Xylitol-resistant mutans streptococci strains and the frequency of xylitol consumption in young children
    Pia Meurman
    Institute of Dentistry, University of Turku, Finland
    Acta Odontol Scand 63:314-6. 2005
  25. ncbi A rare sugar xylitol. Part II: biotechnological production and future applications of xylitol
    Tom Birger Granström
    Rare Sugar Research Center, Kagawa University, Miki cho, Kagawa, 761 0795, Japan
    Appl Microbiol Biotechnol 74:273-6. 2007
    b>Xylitol is the first rare sugar that has global markets. It has beneficial health properties and represents an alternative to current conventional sweeteners...
  26. doi Semi-continuous xylose-to-xylitol bioconversion by Ca-alginate entrapped yeast cells in a stirred tank reactor
    Walter Carvalho
    Departamento de Biotecnologia, Escola de Engenharia de Lorena, Estrada Municipal do Campinho s n, Lorena, SP, Brazil
    Bioprocess Biosyst Eng 31:493-8. 2008
    Candida guilliermondii FTI 20037 cells were entrapped in Ca-alginate beads and used for xylose-to-xylitol bioconversions during five successive batches in a stirred tank reactor...
  27. doi Ethanol and xylitol production from glucose and xylose at high temperature by Kluyveromyces sp. IIPE453
    Sachin Kumar
    Biotechnology Area, Indian Institute of Petroleum, Dehradun, India
    J Ind Microbiol Biotechnol 36:1483-9. 2009
    ..The strain also showed xylitol production from xylose. In batch fermentation, the strain showed maximum ethanol concentration of 82 +/- 0...
  28. ncbi Production of xylitol from Candida tropicalis by using an oxidation-reduction potential-stat controlled fermentation
    Dey Chyi Sheu
    Department of Bioengineering, Tatung University, Taipei 104, Taiwan
    Biotechnol Lett 25:2065-9. 2003
    An on-line device, ORP (oxidation-reduction potential)-stat, was used to control glucose-feeding for enhancing xylitol conversion from D-xylose during an oxygen-limited fermentation by Candida tropicalis...
  29. ncbi Influence of a low xylitol-dose on mutans streptococci colonisation and caries development in preschool children
    P Oscarson
    Lycksele Public Dental Clinic, Umea, Sweden
    Eur Arch Paediatr Dent 7:142-7. 2006
    To evaluate the effect of xylitol-containing tablets on mutans streptococci colonisation and caries development in preschool children.
  30. doi Xylitol does not inhibit xylose fermentation by engineered Saccharomyces cerevisiae expressing xylA as severely as it inhibits xylose isomerase reaction in vitro
    Suk Jin Ha
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, 61801, USA
    Appl Microbiol Biotechnol 92:77-84. 2011
    ..31 g/g) under anaerobic conditions. Interestingly, significant amounts of xylitol (0...
  31. pmc Production of xylitol from D-xylose by a xylitol dehydrogenase gene-disrupted mutant of Candida tropicalis
    Byoung Sam Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Appl Environ Microbiol 72:4207-13. 2006
    b>Xylitol dehydrogenase (XDH) is one of the key enzymes in d-xylose metabolism, catalyzing the oxidation of xylitol to d-xylulose...
  32. pmc Decreased xylitol formation during xylose fermentation in Saccharomyces cerevisiae due to overexpression of water-forming NADH oxidase
    Guo Chang Zhang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
    Appl Environ Microbiol 78:1081-6. 2012
    The recombinant xylose-fermenting Saccharomyces cerevisiae strain harboring xylose reductase (XR) and xylitol dehydrogenase (XDH) from Scheffersomyces stipitis requires NADPH and NAD(+), creates cofactor imbalance, and causes xylitol ..
  33. doi Effect of nutrient supplementation of crude or detoxified concentrated distilled grape marc hemicellulosic hydrolysates on the xylitol production by Debaryomyces hansenii
    José Manuel Salgado
    Department of Chemical Engineering, University of Vigo Campus Ourense, Spain
    Prep Biochem Biotechnol 42:1-14. 2012
    Biosynthesis of xylitol using the yeast Debaryomyces hansenii NRRL Y-7426 was carried out using distilled grape marc (DGM) hemicellulosic hydrolysates directly concentrated by vacuum evaporation or after detoxification with activated ..
  34. doi Improved ethanol and reduced xylitol production from glucose and xylose mixtures by the mutant strain of Candida shehatae ATCC 22984
    Yuan Li
    National Food Research Institute, National Agriculture and Food Research Organization, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Appl Biochem Biotechnol 166:1781-90. 2012
    ..4 g/l of ethanol from 121.3 g/l of xylose, which was 13% higher than that by ATCC 22984. At the same time, xylitol production was reduced by 38% to 10.2 g/l from 16.3 g/l by ATCC 22984...
  35. ncbi High expression of XYL2 coding for xylitol dehydrogenase is necessary for efficient xylose fermentation by engineered Saccharomyces cerevisiae
    Soo Rin Kim
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Metab Eng 14:336-43. 2012
    ..cerevisiae. However, the resulting engineered strains have been reported to exhibit large variations in xylitol accumulation and ethanol yields, generating many hypotheses and arguments for elucidating these phenomena...
  36. ncbi The effect of chlorhexidine acetate/xylitol chewing gum on the plaque and gingival indices of elderly occupants in residential homes
    D Simons
    Dental Caries Research Group, Guy's, King's and St Thomas's Dental Institute, London, UK
    J Clin Periodontol 28:1010-5. 2001
    ..controlled, double-blind, clinical trial was conducted to investigate the effect of a chlorhexidine acetate/xylitol gum (ACHX) on the plaque and gingival indices of 111 elderly occupants in residential homes...
  37. pmc Anaerobic obligatory xylitol production in Escherichia coli strains devoid of native fermentation pathways
    Olubolaji Akinterinwa
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Appl Environ Microbiol 77:706-9. 2011
    ..b>Xylitol production serves as the primary means of NAD(P)(+) regeneration, as glucose is converted primarily to acetate ..
  38. doi Development of a yeast strain for xylitol production without hydrolysate detoxification as part of the integration of co-product generation within the lignocellulosic ethanol process
    Chiung Fang Huang
    Cellulosic ethanol project, Institute of Nuclear Energy Research, Taoyuan County, Taiwan, ROC
    Bioresour Technol 102:3322-9. 2011
    The present study verified an applicable technology of xylitol bioconversion as part of the integration of co-product generation within second-generation bioethanol processes...
  39. ncbi Xylitol, sweeteners, and dental caries
    Kiet A Ly
    Department of Dental Public Health Sciences, the Northwest Alaska Center to Reduce Oral Health Disparities, USA
    Pediatr Dent 28:154-63; discussion 192-8. 2006
    The purpose of this report was to provide an overview of xylitol and other polyol sweeteners and dental caries for clinicians and to discuss current applications for dental practice and potential community-based public health ..
  40. doi Xylitol production from DEO hydrolysate of corn stover by Pichia stipitis YS-30
    Rita C L B Rodrigues
    Departamento de Biotecnologia, DEBIQ, Escola de Engenharia de Lorena, EEL, USP, Universidade de Sao Paulo, P O Box 116, Lorena, SP 12600 970, Brazil
    J Ind Microbiol Biotechnol 38:1649-55. 2011
    ..a D-xylulokinase mutant of Pichia stipitis, FPL-YS30 (xyl3-∆1), converted the stover hydrolysate into xylitol. This research examined the effects of phosphoric or gluconic acids used for neutralization and urea or ammonium ..
  41. doi Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars
    Nikhil U Nair
    Department of Chemical and Biomolecular Engineering, Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Metab Eng 12:462-8. 2010
    The biocatalytic reduction of D-xylose to xylitol requires separation of the substrate from L-arabinose, another major component of hemicellulosic hydrolysate...
  42. doi Role of xylose transporters in xylitol production from engineered Escherichia coli
    Reza Khankal
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    J Biotechnol 134:246-52. 2008
    ..2006 [Cirino, P.C., Chin, J.W., Ingram, L.O., 2006. Engineering Escherichia coli for xylitol production from glucose-xylose mixtures. Biotechnol. Bioeng. 95, 1167-1176.])...
  43. ncbi In vitro testing of xylitol as an anticariogenic agent
    Paul S Sahni
    Indiana University, Indianapolis, USA
    Gen Dent 50:340-3. 2002
    A number of studies involving xylitol chewing gum have demonstrated that xylitol is both noncariogenic and anticariogenic...
  44. ncbi Effect of xylitol-containing chewing gums on interdental plaque-pH in habitual xylitol consumers
    Pernilla Lif Holgerson
    Department of Odontology, Pediatric Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
    Acta Odontol Scand 63:233-8. 2005
    The aim was to investigate the effect of high and low amounts of xylitol on the interdental plaque-pH, directly and after sucrose challenge, in schoolchildren with habitual consumption.
  45. doi Tyr-51 is the proton donor-acceptor for NAD(H)-dependent interconversion of xylose and xylitol by Candida tenuis xylose reductase (AKR2B5)
    Simone L Pival
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, A 8010 Graz, Austria
    FEBS Lett 582:4095-9. 2008
    ..bromide brought about unidirectional rate enhancement ( approximately 2x10(3)-fold at 300mM) for NAD(+)-dependent xylitol oxidation by Y51A...
  46. ncbi Optimization of acid hydrolysis of sugarcane bagasse and investigations on its fermentability for the production of xylitol by Candida guilliermondii
    Rafael Fogel
    Departamento de Engenharia Bioquímica, Escola de Química CT, Universidade Federal do Rio de Janeiro, RJ, CEP 21949 900, Brazil
    Appl Biochem Biotechnol 121:741-52. 2005
    ..conversion (tC) to 75 h (without nitrogen source addition tC > 127 h), and, consequently, improving the rates of xylitol bioproduction...
  47. doi Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats
    Govindasamy Chandramohan
    Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, P O Box 10219, Riyadh 11433, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 24:95-101. 2010
    ..An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented...
  48. ncbi Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants
    E Soderling
    Institute of Dentistry, University of Turku, Finland
    J Dent Res 79:882-7. 2000
    b>Xylitol is effective as a non-cariogenic sugar substitute. Habitual xylitol consumption appears to select for mutans streptococci (MS) with impaired adhesion properties, i.e., they shed easily to saliva from plaque...
  49. ncbi Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli
    E Caglar
    Department of Paediatric Dentistry, School of Dentistry, Yeditepe University, Bagdat cad 238, Goztepe, 34728 Istanbul, Turkey
    Clin Oral Investig 11:425-9. 2007
    The aim was to evaluate the effect of xylitol and probiotic chewing gums on salivary mutans streptococci (MS) and lactobacilli (LB). The material consisted of 80 healthy young adults (21-24 years) who volunteered after informed consent...
  50. ncbi Xylitol for messrooms--a method worth trying to prevent caries among seafarers
    U Saarni
    Finnish Student Health Service, Turku, Finland
    Bull Inst Marit Trop Med Gdynia 48:91-7. 1997
    ..A newer method to prevent caries is systematic use of xylitol. Scientific evidence shows that the addition of small quantities of xylitol, a natural carbohydrate sweetener, to ..
  51. ncbi A model of xylitol production by the yeast Candida mogii
    Worasit Tochampa
    Department of Biotechnology, Kasetsart University, Bangkok, 10900 Thailand
    Bioprocess Biosyst Eng 28:175-83. 2005
    Production of xylitol from xylose in batch fermentations of Candida mogii ATCC 18364 is discussed in the presence of glucose as the cosubstrate...
  52. ncbi Effect of xylitol on mutans streptococci and lactic acid formation in saliva and plaque from adolescents and young adults with fixed orthodontic appliances
    Christina Stecksén-Blicks
    Department of Odontology, Pediatric Dentistry, Umea University, Umea, Sweden
    Eur J Oral Sci 112:244-8. 2004
    This study aimed to investigate two dose regimens of xylitol-containing tablets on the ecology of dental plaque and saliva during treatment with fixed orthodontic appliances. The study group comprised 56 healthy patients (mean age 15...
  53. ncbi Difference in the xylitol sensitivity of acid production among Streptococcus mutans strains and the biochemical mechanism
    H Miyasawa-Hori
    Division of Oral Ecology and Biochemistry, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Oral Microbiol Immunol 21:201-5. 2006
    b>Xylitol inhibits the glycolysis and growth of Streptococcus mutans, but to different degrees among strains. Thus, we studied the biochemical mechanism through which the inhibition varies, using S...
  54. ncbi Enhancement of xylitol productivity and yield using a xylitol dehydrogenase gene-disrupted mutant of Candida tropicalis under fully aerobic conditions
    Byoung Sam Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon, 305 701, Republic of Korea
    Biotechnol Lett 28:1159-62. 2006
    The effects of glycerol and the oxygen transfer rate on the xylitol production rate by a xylitol dehydrogenase gene (XYL2)-disrupted mutant of Candida tropicalis were investigated...
  55. ncbi Evaluation of the dental plaque pH recovery effect of a xylitol lozenge on patients with fixed orthodontic appliances
    Abdulkadir Sengun
    Department of Conservative Dentistry, Faculty of Dentistry, Selcuk University, Campus Konya, Turkey
    Angle Orthod 74:240-4. 2004
    The purpose of this study was to evaluate the influence of a xylitol lozenge on the dental plaque pH profile of fixed orthodontic patients. Twelve volunteers participated in this study...
  56. pmc Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis
    Jung Kul Lee
    BioNgene Co, Ltd, Jongro Ku, Seoul 110 521, Korea
    Appl Environ Microbiol 69:6179-88. 2003
    Xylose reductase (XR) is a key enzyme in D-xylose metabolism, catalyzing the reduction of D-xylose to xylitol. An NADH-preferring XR was purified to homogeneity from Candida parapsilosis KFCC-10875, and the xyl1 gene encoding a 324-amino-..
  57. pmc Cloning and expression of a xylitol-4-dehydrogenase gene from Pantoea ananatis
    J S Aarnikunnas
    Division of Microbiology and Epidemiology, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Appl Environ Microbiol 72:368-77. 2006
    The Pantoea ananatis ATCC 43072 mutant strain is capable of growing with xylitol as the sole carbon source...
  58. pmc Xylitol production from xylose mother liquor: a novel strategy that combines the use of recombinant Bacillus subtilis and Candida maltosa
    Hairong Cheng
    Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China
    Microb Cell Fact 10:5. 2011
    ..In China, more than 50,000 metric tons of xylose mother liquor was produced in 2009, and the management of sugars like xylose that present in the low-cost liquor is a problem...
  59. ncbi Xylitol enhances bacterial killing in the rabbit maxillary sinus
    Christopher L Brown
    Department of Otolaryngology Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242 1093, USA
    Laryngoscope 114:2021-4. 2004
    Factors that alter airway surface liquid (ASL) ionic concentrations may influence the course of sinusitis. Xylitol has been shown to effect ASL ionic composition in vitro and to reduce nasal bacterial carriage, otitis media, and dental ..
  60. ncbi Optimization of fed-batch fermentation for xylitol production by Candida tropicalis
    J H Kim
    Department of Food Science and Technology, Research Center for New Bio Materials in Agriculture, Seoul National University, Suwon 441 744, South Korea
    J Ind Microbiol Biotechnol 29:16-9. 2002
    b>Xylitol, a functional sweetener, was produced from xylose by biological conversion using Candida tropicalis ATCC 13803...
  61. ncbi Microbiological purification of L-arabitol from xylitol mother liquor
    Mingguo Jiang
    College of Chemical Engineering and Ecology, Guangxi University for Nationality, Nanning, 530007, China
    J Microbiol Biotechnol 21:43-9. 2011
    ..Therefore, this study describes a novel L-arabitol production method based on biological purification from the xylitol mother liquor, a cheap and readily available raw material that contains a high concentration of Larabitol...
  62. ncbi Improvement of xylitol production by Candida guilliermondii FTI 20037 previously adapted to rice straw hemicellulosic hydrolysate
    C J Silva
    Department of Biotechnology/FAENQUIL, , Lorena-SP, Brazil
    Lett Appl Microbiol 32:248-52. 2001
    AIMS: To evaluate a simple and economical technique to improve xylitol production using concentrated xylose solutions prepared from rice straw hemicellulosic hydrolysate...
  63. ncbi Increase of xylitol productivity by cell-recycle fermentation of Candida tropicalis using submerged membrane bioreactor
    Soun Gyu Kwon
    Department of Bioscience and Biotechnology, Sejong University, 98 Gunja Dong, Gwangin gu, Seoul 143 747, Korea
    J Biosci Bioeng 101:13-8. 2006
    Candida tropicalis, an osmophilic strain isolated from honeycomb, produced xylitol at a maximal volumetric productivity of 3.5 g l(-1) h(-1) from an initial xylose concentration of 200 g l(-1). Even at a very high xylose concentration, e...
  64. ncbi Novel enzymatic method for the production of xylitol from D-arabitol by Gluconobacter oxydans
    Shun ichi Suzuki
    AminoScience Laboratories, Ajinomoto Co, Inc, Suzuki cho, Kawasaki ku, Kawasaki shi 210 8681, Japan
    Biosci Biotechnol Biochem 66:2614-20. 2002
    Microorganisms capable of producing xylitol from D-arabitol were screened for...
  65. doi Xylitol gum and maternal transmission of mutans streptococci
    Y Nakai
    Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama Shi, Okayama 700 8525, Japan
    J Dent Res 89:56-60. 2010
    ..This study confirmed the effectiveness of maternal early exposure to xylitol chewing gum on mother-child transmission of MS...
  66. ncbi Lipase-catalyzed synthesis of xylitol monoesters: solvent engineering approach
    E Castillo
    Departamento de Bioingeniería, Instituto de Biotecnologia, UNAM, Apartado Postal 510 3, Cuernavaca, Morelos 62271, Mexico
    J Biotechnol 102:251-9. 2003
    A solvent engineering strategy was applied to the lipase-catalyzed synthesis of xylitol-oleic acid monoesters. The different esterification degrees for this polyhydroxylated molecule were examined in different organic solvent mixtures...
  67. ncbi Cloning of the xylitol dehydrogenase gene from Gluconobacter oxydans and improved production of xylitol from D-arabitol
    Masakazu Sugiyama
    AminoScience Laboratories, Ajinomoto Co, Inc, Suzuki cho, Kawasaki ku, Kawasaki shi 210 8681, Japan
    Biosci Biotechnol Biochem 67:584-91. 2003
    b>Xylitol dehydrogenase (XDH) was purified from the cytoplasmic fraction of Gluconobacter oxydans ATCC 621. The purified enzyme reduced D-xylulose to xylitol in the presence of NADH with an optimum pH of around 5.0...
  68. pmc D-xylose metabolism in Hypocrea jecorina: loss of the xylitol dehydrogenase step can be partially compensated for by lad1-encoded L-arabinitol-4-dehydrogenase
    Bernhard Seiboth
    Abteilung für Angewandte Biochemie und Gentechnologie, Institut fur Verfahrenstechnik, Umwelttechnik, und Technische Biowissenschaften, A 1060 Wien, Austria
    Eukaryot Cell 2:867-75. 2003
    ..the D-xylose pathway in Hypocrea jecorina (anamorph: Trichoderma reesei), we cloned the xdh1 gene, encoding NAD-xylitol dehydrogenase, which catalyzes the second step of fungal D-xylose catabolism...
  69. ncbi Synergistic inhibition by combination of fluoride and xylitol on glycolysis by mutans streptococci and its biochemical mechanism
    H Maehara
    Department of Lifelong Oral Health Sciences, Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Caries Res 39:521-8. 2005
    The purpose of this study was to evaluate the combined inhibitory effect of fluoride and xylitol on acid production by mutans streptococci, Streptococcus mutans NCTC10449 and Streptococcus sobrinus 6715, from glucose under strictly ..
  70. ncbi Utilization of xylitol dehydrogenase in a combined microbial/enzymatic process for production of xylitol from D-glucose
    Gerhard Mayer
    Division of Biochemical Engineering, Institute of Food Technology, University of Agricultural Sciences Vienna, Austria
    Appl Biochem Biotechnol 98:577-89. 2002
    The production of xylitol from D-glucose occurs through a three-step process in which D-arabitol and D-xylulose are formed as the first and second intermediate product, respectively, and both are obtained via microbial bioconversion ..
  71. doi Six months of daily high-dose xylitol in high-risk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci
    G Campus
    Dental Institute, University of Sassari, Sassari, Italy
    Caries Res 43:455-61. 2009
    A randomized clinical trial was designed to evaluate the effect of daily high-dose xylitol chewing gum on plaque pH and salivary mutans streptococci (MS) in a sample of schoolchildren at high risk of caries...
  72. ncbi Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children
    Jaana T Autio
    Department of Operative Dentistry, University of Florida, Gainesville, Florida, USA
    ASDC J Dent Child 69:81-6, 13. 2002
    ..The purpose of this study was to evaluate the effect of xylitol gum in salivary S. mutans levels in preschool children...
  73. pmc Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa
    Ryan Woodyer
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 S Mathews Ave, Urbana, IL 61801, USA
    Appl Environ Microbiol 71:1642-7. 2005
    ..This enzyme is one of the most active XRs thus far characterized and may be used for the in vitro production of xylitol.
  74. ncbi Field trial on caries prevention with xylitol candies among disabled school students
    E Honkala
    Faculty of Dentistry, Kuwait University, Safat, Kuwait
    Caries Res 40:508-13. 2006
    ..In a 1999 survey high caries levels were found among physically disabled school students in Kuwait...
  75. ncbi Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults
    Tsuneyuki Oku
    Graduate School of Human Health Science, Siebold University of Nagasaki, Nagayo, Nagasaki 851 2195, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:13-20. 2007
    ..The objective is to estimate the non-effective dosage that does not cause transitory diarrhea for xylitol, lactitol, and erythritol in healthy subjects...
  76. ncbi Effect of maternal use of chewing gums containing xylitol, chlorhexidine or fluoride on mutans streptococci colonization in the mothers' infant children
    Ingrid Thorild
    Public Dental Clinic, Varberg, Sweden
    Oral Health Prev Dent 1:53-7. 2003
    The aim was to evaluate the effect of maternal use of chewing gums containing xylitol, chlorhexidine/xylitol or fluoride on the prevalence of mutans streptococci (MS) in the mothers' 18-month-old offsprings.
  77. ncbi Influence of cultivation conditions on xylose-to-xylitol bioconversion by a new isolate of Debaryomyces hansenii
    Fabio C Sampaio
    Department of Microbiology, Instituto de Biotecnologia Aplicada à Agropecuária, Federal University of Vicosa, Av P H Rolfs s n, 36571 000 Vicosa, Minas Gerais, Brazil
    Bioresour Technol 99:502-8. 2008
    About 270 yeast isolates were screened for xylitol production using xylose as the sole carbon source. The best isolate, Debaryomyces hansenii UFV-170, released 5...
  78. ncbi Ion-molecule reactions for the characterization of polyols and polyol mixtures by ESI/FT-ICR mass spectrometry
    Michael A Watkins
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, and Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Anal Chem 77:1385-92. 2005
    ..The utility of this method for the analysis of polyols as single-component solutions, as mixtures, or in HPLC effluent (LC-MS analysis) is demonstrated...
  79. ncbi Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase
    Federico Forneris
    Department of Genetics and Microbiology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Biochemistry 47:978-85. 2008
    ..in its native state and in complex with both six-carbon (mannitol and sorbitol) and five-carbon substrates (xylitol)...
  80. ncbi Effect of a xylitol and fluoride containing toothpaste on the remineralization of human enamel in vitro
    Hiroshi Sano
    Product Development Department, International Division, Lion Corporation, Tokyo, Japan
    J Oral Sci 49:67-73. 2007
    The aim of this study was to examine the effect of a fluoride and xylitol containing toothpaste on the remineralization of human enamel using Quantitative Light-induced Fluorescence (QLF)...
  81. ncbi Xylitol concentration in saliva and dental plaque after use of various xylitol-containing products
    P Lif Holgerson
    Department of Odontology, Pediatric Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
    Caries Res 40:393-7. 2006
    The study consisted of two sets of experiments, one in saliva and one in dental plaque. The xylitol concentration in saliva was determined enzymatically in 12 children (mean age 11...
  82. pmc Xylitol inhibits inflammatory cytokine expression induced by lipopolysaccharide from Porphyromonas gingivalis
    Su Ji Han
    Department of Oral Microbiology, School of Dentistry, Pusan National University, Pusan, Korea 602 739
    Clin Diagn Lab Immunol 12:1285-91. 2005
    ..b>Xylitol stands out and is widely believed to possess anticaries properties...
  83. ncbi Electrochemical reduction of xylose to xylitol by whole cells or crude enzyme of Candida peltata
    Sun Mi Park
    Department of Biological Engineering, Seokyeong University, Seoul 136 704, Republic of Korea
    J Microbiol 43:451-5. 2005
    ..were applied to an electrochemical bioreactor, in order to induce an increment of the reduction of xylose to xylitol. Neutral red was utilized as an electron mediator in the whole cell reactor, and a graphite-Mn(IV) electrode was ..
  84. ncbi Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin
    Alex C McLaren
    Department of Orthopaedic Surgery, University of Arkansas Medical Sciences, Little Rock, AR, USA
    Clin Orthop Relat Res 451:25-8. 2006
    ..We propose xylitol, a naturally occurring sweetener with direct antibiofilm properties, as a filler material...
  85. pmc Metabolic engineering of Saccharomyces cerevisiae for conversion of D-glucose to xylitol and other five-carbon sugars and sugar alcohols
    Mervi H Toivari
    VTT Technical Research Centre of Finland, P O Box 1000, FI 02044 VTT, Espoo, Finland
    Appl Environ Microbiol 73:5471-6. 2007
    Recombinant Saccharomyces cerevisiae strains that produce the sugar alcohols xylitol and ribitol and the pentose sugar D-ribose from D-glucose in a single fermentation step are described. A transketolase-deficient S...
  86. ncbi Effect of xylitol and sorbitol on plaque acidogenesis
    Christian H Splieth
    Department for Preventive and Pediatric Dentistry, Ernst Moritz Arndt University, Greifswald, Germany
    Quintessence Int 40:279-85. 2009
    To evaluate the in vivo potential of xylitol to reduce plaque acidogenicity in comparison to sorbitol.
  87. ncbi Xylitol: effects on the acquisition of cariogenic species in infants
    Margherita Fontana
    Microbial Caries Facility, School of Dentistry and Medicine, Indiana University, Indianapolis, USA
    Pediatr Dent 31:257-66. 2009
    The purpose of this study was to examine the effects of xylitol gum (XG) on the acquisition pattern of 39 bacterial species, including mutans streptococci (MS), in infants.
  88. pmc Xylitol pediatric topical oral syrup to prevent dental caries: a double-blind randomized clinical trial of efficacy
    Peter Milgrom
    Northwest Center to Reduce Oral Health Disparities, Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, WA 98195 7475, USA
    Arch Pediatr Adolesc Med 163:601-7. 2009
    To evaluate the effectiveness of a xylitol pediatric topical oral syrup to reduce the incidence of dental caries among very young children and to evaluate the effect of xylitol in reducing acute otitis media in a subsequent study.
  89. ncbi Xylitol for caries prevention
    John Peldyak
    Institute of Dentistry, University of Turku, Turku, Finland
    J Dent Hyg 76:276-85. 2002
    ..When tested as a sucrose replacer, or even as a small dietary addition, systematic xylitol use leads to impressive reductions in caries incidence...
  90. ncbi Anticaries efficacy of a sodium monofluorophosphate dentifrice containing xylitol in a dicalcium phosphate dihydrate base. A 30-month caries clinical study in Costa Rica
    Jorge L Sintes
    International Relations and Convention Management, GBD Oral Care, Colgate Palmolive Technology Center, Piscataway, NJ, USA
    Am J Dent 15:215-9. 2002
    ..836% sodium monofluorophosphate (1100 ppm F) in a dicalcium phosphate dihydrate base plus 10% xylitol; and (2) a positive control dentifrice containing 0...
  91. pmc Xylitol and D-arabitol toxicities due to derepressed fructose, galactitol, and sorbitol phosphotransferases of Escherichia coli
    A M Reiner
    J Bacteriol 132:166-73. 1977
    d-Arabitol was observed to be toxic to many laboratory strains of Escherichia coli K-12, and xylitol was found to be toxic to an existing E. coli C mutant strain...
  92. ncbi Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients
    M A Valero
    Clinical Nutrition, Hospital Doce de Octubre, Madrid, Spain
    Eur J Clin Nutr 55:1111-6. 2001
    ..patients were randomly divided into two groups receiving either glucose (G), n=71, or glucose-fructose-xylitol 2:1:1 (GFX), n=67...
  93. ncbi Chemostat study of xylitol production by Candida guilliermondii
    T Granström
    Helsinki University of Technology, Laboratory of Bioprocess Engineering, Finland
    Appl Microbiol Biotechnol 55:36-42. 2001
    The mechanism of production of xylitol from xylose by Candida guilliermondii was studied using chemostat cultures and enzymatic assays. The maximum dilution rate in aerobic conditions was 0.34 1/h. No xylitol was produced...
  94. ncbi Production of ethanol and xylitol from corn cobs by yeasts
    F Latif
    National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    Bioresour Technol 77:57-63. 2001
    ..Maximal xylitol concentration of 21, 20 and 15 g/l from 200 g/l (w/v) dry corn cobs was obtained by C...
  95. pmc Effect of xylitol on growth of Streptococcus pneumoniae in the presence of fructose and sorbitol
    T Tapiainen
    Department of Pediatrics, University of Oulu, Oulu, Finland
    Antimicrob Agents Chemother 45:166-9. 2001
    b>Xylitol is effective in preventing acute otitis media by inhibiting the growth of Streptococcus pneumoniae. To clarify this inhibition we used fructose, which is known to block similar growth inhibition observed in Streptococcus mutans...
  96. ncbi Maintaining mutans streptococci suppression with xylitol chewing gum
    G H Hildebrandt
    School of Dentistry, University of Minnesota, Minneapolis 55455 0348, USA
    J Am Dent Assoc 131:909-16. 2000
    ..Oral MS levels, however, tend to quickly return to baseline values without further intervention. In this clinical study, the authors evaluated the effect of xylitol chewing gum on MS regrowth.
  97. ncbi Xylitol candies in caries prevention: results of a field study in Estonian children
    P Alanen
    Institute of Dentistry, University of Turku, Finland
    Community Dent Oral Epidemiol 28:218-24. 2000
    ..reported significant reductions in dental caries occurrence associated with the use of chewing gum containing xylitol. No other xylitol products besides chewing gum have so far been tested in field trials...
  98. ncbi Development of a xylitol biosensor composed of xylitol dehydrogenase and diaphorase
    K Takamizawa
    Department of Bioprocessing, Faculty of Agriculture, Gifu University, Japan
    Can J Microbiol 46:350-7. 2000
    In preparation for the development of a xylitol biosensor, the xylitol dehydrogenase of Candida tropicalis IFO 0618 was partially purified and characterized. The optimal pH and temperature of the xylitol dehydrogenase were pH 8...
  99. ncbi Morphological changes in Streptococcus mutans after chewing gum containing xylitol for twelve months
    Young Eun Lee
    Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, SamDuk Dong, Daegu 700 412, Republic of Korea
    Curr Microbiol 58:332-7. 2009
    Few studies have been conducted to evaluate the effect of xylitol on the virulence and morphology of Streptococcus mutans (S. mutans). This study was conducted to evaluate changes in the morphology and virulence of S...
  100. pmc The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing
    J Zabner
    Howard Hughes Medical Institute, Departments of Internal Medicine, Pediatrics, and Physiology and Biophysics, and Nuclear Magnetic Resonance Facility, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 97:11614-9. 2000
    ..We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt ..
  101. pmc The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol
    R Bais
    Biochem J 230:53-60. 1985
    ..of the two enzymes was tested to determine the conditions that favour the formation of glycolaldehyde from xylitol. The results indicate that few of these metabolites affect the activity of ketohexokinase, but that aldolase can ..

Research Grants79

  1. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel Shugars; Fiscal Year: 2007
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  2. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2007
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  3. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2001
    ..young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the ..
  4. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2004
    ..young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the ..
  5. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2003
    ..young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the ..
  6. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2002
    ..young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the ..
  7. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2000
    ..young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the ..
  8. LSU DENTAL COBRE: PREVENTING CARIES BY INHIBITING S. MUTANS TRANSMISSION
    ANDRETTA PORTER WILLIAMS; Fiscal Year: 2004
    ..Chlorhexidine and xylitol are two antimicrobial agents that have been used primarly outside the United States as caries preventive agents...
  9. PROCESSING OF TASTE MIXTURES BY BRAINSTEM NEURONS
    David Smith; Fiscal Year: 1990
    ..NaCl, citric acid, and quinine hydrochloride (QHCl) and their mixtures (heterogeneous) and sucrose, fructose, xylitol, and Na-saccharin and their mixtures (homogeneous)...
  10. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel Shugars; Fiscal Year: 2009
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  11. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel A Shugars; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  12. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel Shugars; Fiscal Year: 2006
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  13. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Amaechi; Fiscal Year: 2007
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  14. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    GREGG GILBERT; Fiscal Year: 2007
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  15. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    GREGG GILBERT; Fiscal Year: 2006
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  16. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    John Brown; Fiscal Year: 2006
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  17. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    GREGG GILBERT; Fiscal Year: 2009
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  18. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Amaechi; Fiscal Year: 2009
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  19. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    GREGG GILBERT; Fiscal Year: 2009
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  20. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Tochukwu Amaechi; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  21. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    Gregg H Gilbert; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  22. Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo
    CHIFU HUANG; Fiscal Year: 2006
    ..g. phenylketonurics and diabetics). Moreover, altered sugar alcohol substitute sweeteners, i.e. sorbitol, xylitol, that have been marketed as noncariogenic sweeteners, and more recently as sweeteners for low carbohydrate diets, ..
  23. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    WILLIAM MARION VOLLMER; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  24. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James D Bader; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  25. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    William Vollmer; Fiscal Year: 2009
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  26. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    William Vollmer; Fiscal Year: 2007
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  27. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    WILLIAM MARION VOLLMER; Fiscal Year: 2011
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  28. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2006
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  29. CARIES PREVENTION IN ALASKAN NATIVE INFANTS
    David Grossman; Fiscal Year: 2002
    ..Chlorhexidine and xylitol are two agents that have been shown to reduce dental decay and MS counts...
  30. CARIES PREVENTION IN ALASKAN NATIVE INFANTS
    David Grossman; Fiscal Year: 2001
    ..Chlorhexidine and xylitol are two agents that have been shown to reduce dental decay and MS counts...
  31. Xylitol syrup for the prevention of acute otitis media in otitis-prone children
    Louis Vernacchio; Fiscal Year: 2009
    ..Challenge Topic 04-DC-101: Prevention of Otitis Media, we propose a clinical trial of a preparation of viscous xylitol with a mucosal adherence agent for the prevention of acute otitis media (AOM) in otitis-prone children...
  32. Xylitol syrup for the prevention of acute otitis media in otitis-prone children
    Louis Vernacchio; Fiscal Year: 2010
    ..Challenge Topic 04-DC-101: Prevention of Otitis Media, we propose a clinical trial of a preparation of viscous xylitol with a mucosal adherence agent for the prevention of acute otitis media (AOM) in otitis-prone children...
  33. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2010
    ..b>Xylitol, a 5-carbon sugar, can lower ASL salt concentration without providing a carbon-source for bacteria...
  34. XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXIS
    Louis Vernacchio; Fiscal Year: 2002
    ..b>Xylitol, a naturally occurring sugar alcohol, has been proposed as a prophylactic therapy for AOM...
  35. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2009
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  36. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    William Vollmer; Fiscal Year: 2006
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  37. Structural Basis of Selective Permeability in Aquaporin
    Dax Fu; Fiscal Year: 2003
    ..Aim (2) will determine the structures of GlpF in complex with ribitol and its stereoisomer xylitol to elucidate the structural basis for stereo-selectivity in GlpF. Aim (3) will crystallize AqpZ, an E...
  38. Structural Basis of Selective Permeability in Aquaporin
    Dax Fu; Fiscal Year: 2002
    ..Aim (2) will determine the structures of GlpF in complex with ribitol and its stereoisomer xylitol to elucidate the structural basis for stereo-selectivity in GlpF. Aim (3) will crystallize AqpZ, an E...
  39. Structural Basis of Selective Permeability in Aquaporin
    Dax Fu; Fiscal Year: 2004
    ..Aim (2) will determine the structures of GlpF in complex with ribitol and its stereoisomer xylitol to elucidate the structural basis for stereo-selectivity in GlpF. Aim (3) will crystallize AqpZ, an E...
  40. Structural Basis of Selective Permeability in Aquaporin
    Dax Fu; Fiscal Year: 2006
    ..Aim (2) will determine the structures of GlpF in complex with ribitol and its stereoisomer xylitol to elucidate the structural basis for stereo-selectivity in GlpF. Aim (3) will crystallize AqpZ, an E...
  41. Structural Basis of Selective Permeability in Aquaporin
    Dax Fu; Fiscal Year: 2005
    ..Aim (2) will determine the structures of GlpF in complex with ribitol and its stereoisomer xylitol to elucidate the structural basis for stereo-selectivity in GlpF. Aim (3) will crystallize AqpZ, an E...
  42. Aerosolized xylitol for ventilator-associated pneumonia
    Lakshmi Durairaj; Fiscal Year: 2009
    ..The focus of this proposal is to study the effectiveness of a new intervention namely xylitol, a 5-carbon sugar, for the prevention of ventilator-associated pneumonia, a common nosocomial infection among ..
  43. Aerosolized xylitol for ventilator-associated pneumonia
    Lakshmi Durairaj; Fiscal Year: 2006
    ..The focus of this proposal is to study the effectiveness of a new intervention namely xylitol, a 5-carbon sugar, for the prevention of ventilator-associated pneumonia, a common nosocomial infection among ..
  44. Aerosolized xylitol for ventilator-associated pneumonia
    Lakshmi Durairaj; Fiscal Year: 2005
    ..The focus of this proposal is to study the effectiveness of a new intervention namely xylitol, a 5-carbon sugar, for the prevention of ventilator-associated pneumonia, a common nosocomial infection among ..
  45. XYLITOL CLINCIAL STUDIES FOR CARIES PREVENTION
    Peter Milgrom; Fiscal Year: 2001
    b>Xylitol could be effective as a preventive intervention in helping reduce oral health disparities, especially in Head Start and school-based meal programs...
  46. Airway Biology and Pathogenesis of Cystic Fibrosis
    Michael Welsh; Fiscal Year: 2003
    ..the compelling hypothesis that reducing ASL salt concentrations in vivo, by administering the non-ionic osmolyte xylitol will prevent or slow the progression of CF airway disease...
  47. SCOR in Airway Biology and Pathogenesis of Cystic Fibrosis
    Michael Welsh; Fiscal Year: 2007
    ..the compelling hypothesis that reducing ASL salt concentrations in vivo, by administering the non-ionic osmolyte xylitol will prevent or slow the progression of CF airway disease...
  48. SCOR in Airway Biology and Pathogenesis of Cystic Fibro*
    Michael Welsh; Fiscal Year: 2006
    ..the compelling hypothesis that reducing ASL salt concentrations in vivo, by administering the non-ionic osmolyte xylitol will prevent or slow the progression of CF airway disease...
  49. SCOR in Airway Biology and Pathogenesis of Cystic Fibro*
    Michael Welsh; Fiscal Year: 2005
    ..the compelling hypothesis that reducing ASL salt concentrations in vivo, by administering the non-ionic osmolyte xylitol will prevent or slow the progression of CF airway disease...
  50. SCOR in Airway Biology and Pathogenesis of Cystic Fibro*
    Michael Welsh; Fiscal Year: 2004
    ..the compelling hypothesis that reducing ASL salt concentrations in vivo, by administering the non-ionic osmolyte xylitol will prevent or slow the progression of CF airway disease...
  51. CORE--MICROBIOLOGY
    Peter Milgrom; Fiscal Year: 2001
    ..mutans from clinical oral samples. They will characterize the clinical S. mutans from clinical oral samples of xylitol susceptibility using multiple assays...
  52. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2004
    ..The intervention is the daily use of xylitol lozenges...
  53. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2005
    ..The intervention is the daily use of xylitol lozenges...
  54. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    William Vollmer; Fiscal Year: 2008
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  55. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Amaechi; Fiscal Year: 2008
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  56. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel Shugars; Fiscal Year: 2008
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  57. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    GREGG GILBERT; Fiscal Year: 2008
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  58. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2008
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study ..
  59. Biotech & Materials Research to Reduce Caries Disparity
    Peter Milgrom; Fiscal Year: 2005
    ..The conference will be co-sponsored by the Northwest/Alaska Center to Reduce Oral Health Disparities, the University of Washington UWeb Bioengineering Center, and the Salivary Diagnostics Project. ..
  60. Fluoride Varnish to Prevent Caries in Toddlers - An Expanded Immunization Program
    Peter Milgrom; Fiscal Year: 2007
    ..Keywords: fluoride varnish, dental caries, oral health, early prevention, multi-center, toddlers. [unreadable] [unreadable] [unreadable]..
  61. Fluoride Varnish to Prevent Caries in Toddlers - An Expanded Immunization Program
    Peter Milgrom; Fiscal Year: 2008
    ..Keywords: fluoride varnish, dental caries, oral health, early prevention, multi-center, toddlers. [unreadable] [unreadable] [unreadable]..
  62. Northwest/Alaska/Hawaii Center to Reduce Oral Health Disparities
    Peter Milgrom; Fiscal Year: 2008
    ....
  63. XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXIS
    Louis Vernacchio; Fiscal Year: 2003
    ..b>Xylitol, a naturally occurring sugar alcohol, has been proposed as a prophylactic therapy for AOM...
  64. Aerosolized xylitol for ventilator-associated pneumonia
    Lakshmi Durairaj; Fiscal Year: 2008
    ..The focus of this proposal is to study the effectiveness of a new intervention namely xylitol, a 5-carbon sugar, for the prevention of ventilator-associated pneumonia, a common nosocomial infection among ..
  65. Aerosolized xylitol for ventilator-associated pneumonia
    Lakshmi Durairaj; Fiscal Year: 2007
    ..The focus of this proposal is to study the effectiveness of a new intervention namely xylitol, a 5-carbon sugar, for the prevention of ventilator-associated pneumonia, a common nosocomial infection among ..
  66. Ligand-Receptor Segregation and Airway Remodeling
    Joseph Zabner; Fiscal Year: 2005
    ..We hypothesize that in the asthmatic airways, alterations in the epithelial barrier play a central role in airway epithelial remodeling. ..
  67. Practitioners Engaged in Applied Research and Learning
    Jonathan Ship; Fiscal Year: 2006
    ..In summary, the PEARL Network is uniquely positioned to establish and Maintain a PBRN that will conduct research studies designed to positively impact oral health. ..
  68. Ligand-Receptor Segregation and Airway Remodeling
    Joseph Zabner; Fiscal Year: 2007
    ..We hypothesize that in the asthmatic airways, alterations in the epithelial barrier play a central role in airway epithelial remodeling. ..
  69. Ligand-Receptor Segregation and Airway Remodeling
    Joseph Zabner; Fiscal Year: 2004
    ..We hypothesize that in the asthmatic airways, alterations in the epithelial barrier play a central role in airway epithelial remodeling. ..
  70. Practitioners Engaged in Applied Research and Learning
    Van Thompson; Fiscal Year: 2008
    ..In summary, the PEARL Network is uniquely positioned to establish and Maintain a PBRN that will conduct research studies designed to positively impact oral health. ..
  71. Xylitol Enhancement of Bacterial Killing by Airway
    Joseph Zabner; Fiscal Year: 2003
    ..This could reduce ASL NaCI concentration by substituting the osmotic effect of NaCI with a non-ionic osmolyte. Xylitol is a simple 5-carbon sugar, commonly used as a non-metabolizable sweetener...