uronic acids

Summary

Summary: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)

Top Publications

  1. ncbi Effect of enzyme treatment during mechanical extraction of olive oil on phenolic compounds and polysaccharides
    E Vierhuis
    Department of Agrotechnology and Food Sciences, Laboratory of Food Chemistry, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    J Agric Food Chem 49:1218-23. 2001
  2. pmc Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth
    Mireia Lopez-Siles
    Grup de Microbiologia Clínica i Malalties Infeccioses, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Girona, Spain
    Appl Environ Microbiol 78:420-8. 2012
  3. ncbi Quantification of uronic acids in tea polysaccharide conjugates and their antioxidant properties
    Haixia Chen
    Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Agric Food Chem 52:3333-6. 2004
  4. ncbi Distribution of uronic acids in xylans from various species of soft- and hardwood as determined by MALDI mass spectrometry
    A Jacobs
    Swedish Pulp and Paper Research Institute (STFI, P.O. Box 5604, SE-11486 Stockholm, Sweden
    Biomacromolecules 2:979-90. 2001
  5. doi Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes
    Mamoru Igarashi
    Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Int J Mol Med 27:821-7. 2011
  6. ncbi Two mathematical models for the correction of carbohydrate and protein interference in the determination of uronic acids by the m-hydroxydiphenyl method
    Miguel Anxo Murado
    Instituto de Investigacions Marinas CSIC, r Eduardo Cabello 6, Vigo 36208, Galicia, Spain
    Biotechnol Appl Biochem 41:209-16. 2005
  7. ncbi [Comparison of Echinops species on the basis of the monosaccharide composition of polysaccharides]
    Gyongyi Gyemant
    Debreceni Egyetem, Biokémiai Tanszék, Debrecen, Egyetem tér 1 Hungary 4032
    Acta Pharm Hung 73:77-9. 2003
  8. ncbi An arabinogalactan from the skin of Opuntia ficus-indica prickly pear fruits
    Youssef Habibi
    Centre de Recherches sur les Macromolecules Vegetales, CNRS, and Universite Joseph Fourier, Grenoble, France
    Carbohydr Res 339:1201-5. 2004
  9. ncbi A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates
    Maria Fuller
    Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, North Adelaide, SA 5006, Australia
    Glycobiology 16:318-25. 2006
  10. ncbi Structural features of pectic polysaccharides from the skin of Opuntia ficus-indica prickly pear fruits
    Y Habibi
    Centre de Recherches sur les Macromolecules Vegetales, C N R S, and Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
    Carbohydr Res 339:1119-27. 2004

Research Grants

  1. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
  2. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
  3. Post-biosynthetic remodeling of heparan sulfate
    Joseph Zaia; Fiscal Year: 2010
  4. An in-situ gelling nasal vaccine delivery platform
    YAWEI NI; Fiscal Year: 2005
  5. An Inactivated Influenza Nasal Powder Vaccine
    YAWEI NI; Fiscal Year: 2004

Detail Information

Publications201 found, 100 shown here

  1. ncbi Effect of enzyme treatment during mechanical extraction of olive oil on phenolic compounds and polysaccharides
    E Vierhuis
    Department of Agrotechnology and Food Sciences, Laboratory of Food Chemistry, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    J Agric Food Chem 49:1218-23. 2001
    ..Also, the content of uronic acids in the buffer soluble extract increased considerably due to the use of the enzyme preparations...
  2. pmc Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth
    Mireia Lopez-Siles
    Grup de Microbiologia Clínica i Malalties Infeccioses, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Girona, Spain
    Appl Environ Microbiol 78:420-8. 2012
    ..Many F. prausnitzii isolates were able to utilize uronic acids for growth, an ability previously thought to be confined to Bacteroides spp. among human colonic anaerobes...
  3. ncbi Quantification of uronic acids in tea polysaccharide conjugates and their antioxidant properties
    Haixia Chen
    Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Agric Food Chem 52:3333-6. 2004
    A technique of high-performance liquid chromatography (HPLC) was described for the measurement of total uronic acids in tea polysaccharide conjugates...
  4. ncbi Distribution of uronic acids in xylans from various species of soft- and hardwood as determined by MALDI mass spectrometry
    A Jacobs
    Swedish Pulp and Paper Research Institute (STFI, P.O. Box 5604, SE-11486 Stockholm, Sweden
    Biomacromolecules 2:979-90. 2001
    ....
  5. doi Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes
    Mamoru Igarashi
    Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Int J Mol Med 27:821-7. 2011
    ..action of GlcN, we examined the effects of GlcN-derivatives (GlcN and N-acetyl-D-glucosamine) and uronic acids (D-glucuronic acid and D-galacturonic acid) (0...
  6. ncbi Two mathematical models for the correction of carbohydrate and protein interference in the determination of uronic acids by the m-hydroxydiphenyl method
    Miguel Anxo Murado
    Instituto de Investigacions Marinas CSIC, r Eduardo Cabello 6, Vigo 36208, Galicia, Spain
    Biotechnol Appl Biochem 41:209-16. 2005
    The most common method in the routine determination of uronic acids, the m-hydroxydiphenyl reaction, recently adapted to rapid microplate analysis, has as a main inconvenience, in any one of their modalities, interferences due to the ..
  7. ncbi [Comparison of Echinops species on the basis of the monosaccharide composition of polysaccharides]
    Gyongyi Gyemant
    Debreceni Egyetem, Biokémiai Tanszék, Debrecen, Egyetem tér 1 Hungary 4032
    Acta Pharm Hung 73:77-9. 2003
    ..The main monosaccharides are glucose in E. orientalis and glucose and mannose in E. commutatus. Glucuronic acid is the uronic acid component in both species...
  8. ncbi An arabinogalactan from the skin of Opuntia ficus-indica prickly pear fruits
    Youssef Habibi
    Centre de Recherches sur les Macromolecules Vegetales, CNRS, and Universite Joseph Fourier, Grenoble, France
    Carbohydr Res 339:1201-5. 2004
    ..This polysaccharide is thus an arabinogalactan that can be classified in the type I of the arabinogalactan family...
  9. ncbi A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates
    Maria Fuller
    Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, North Adelaide, SA 5006, Australia
    Glycobiology 16:318-25. 2006
    ....
  10. ncbi Structural features of pectic polysaccharides from the skin of Opuntia ficus-indica prickly pear fruits
    Y Habibi
    Centre de Recherches sur les Macromolecules Vegetales, C N R S, and Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
    Carbohydr Res 339:1119-27. 2004
    ..The side chains contained highly branched alpha-(1-->5)-linked arabinan and short linear beta-(1-->4)-linked galactan...
  11. ncbi Changes in cell wall pectins accompanying tomato (Lycopersicon esculentum Mill.) paste manufacture
    Montaña Cámara Hurtado
    Morning Star Packing Company, Williams and Los Banos, California, USA
    J Agric Food Chem 50:273-8. 2002
    ..Juice content of polymeric uronic acids (i.e., pectin) also rose with concentration, but to a lesser degree than the increase in soluble solids...
  12. doi Compositional analysis and rheological properties of gum kondagogu (Cochlospermum gossypium): a tree gum from India
    V T P Vinod
    Jonaki, Board of Radiation and Isotope Technology, CCMB Campus, Uppal Road, Hyderabad 500 007, Andhra Pradesh, India
    J Agric Food Chem 56:2199-207. 2008
    ..Compositional analysis of the gum by HPLC and LC-MS revealed uronic acids to be the major component of the polymer ( approximately 26 mol %)...
  13. ncbi Soybean (Glycine max) cell wall composition and availability to feed enzymes
    Imed Ouhida
    Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Bellaterra E 08193, Barcelona, Spain
    J Agric Food Chem 50:1933-8. 2002
    ..1%), glucose (27.8%), arabinose (13.3%), and uronic acids (17.6%), which accounted for 76% of the water insoluble polysaccharides in soybean cotyledons (WUc)...
  14. ncbi The structural motif in chondroitin sulfate for adhesion of Plasmodium falciparum-infected erythrocytes comprises disaccharide units of 4-O-sulfated and non-sulfated N-acetylgalactosamine linked to glucuronic acid
    Wengang Chai
    Medical Research Council Glycosciences Laboratory, Imperial College School of Medicine, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 277:22438-46. 2002
    ....
  15. ncbi Water-soluble polysaccharides from Angelica sinensis (Oliv.) Diels: Preparation, characterization and bioactivity
    Yuanlin Sun
    School of Food Science and Technology, Southern Yangtze University, Wuxi 214036, China
    Int J Biol Macromol 36:283-9. 2005
    ..The results showed that ASP3 can protect leucocytes and lymphocytes of mice against radiation induced damage, which has potential radioprotective effect on acute radiation injured mice...
  16. ncbi Primary cell wall composition of bryophytes and charophytes
    Zoë A Popper
    The Edinburgh Cell Wall Group, Institute of Cell and Molecular Biology, The University of Edinburgh, David Rutherford Building, Mayfield Road, Edinburgh EH9 3JH, UK
    Ann Bot 91:1-12. 2003
    ..2) Uronic acids: acid hydrolysis of PCW-rich material from the charophytes, the hornwort, thalloid and leafy liverworts and a ..
  17. ncbi QUASIMODO1 is expressed in vascular tissue of Arabidopsis thaliana inflorescence stems, and affects homogalacturonan and xylan biosynthesis
    Caroline Orfila
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark
    Planta 222:613-22. 2005
    ....
  18. ncbi Effects of boron deficiency in cell suspension cultures of Populus alba L
    Koichi Kakegawa
    Department of Forest Chemistry, Forestry and Forest Products Research Institute, Matsunosato 1, Tukuba, Ibaraki, 305 8687, Japan
    Plant Cell Rep 23:573-8. 2005
    ..Our results suggest that boron deficiency causes a weakening of the interaction among pectic polysaccharides due to a decrease in boron-rhamnogalacturonanII cross-linkage...
  19. pmc Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms
    Daniel J Wozniak
    Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 100:7907-12. 2003
    ....
  20. ncbi Structure of a highly substituted beta-xylan of the gum exudate of the palm Livistona chinensis (Chinese fan)
    Juliana Maurer-Menestrina
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, Caixa Postal 19046, 81531 990 Curitiba, PR, Brazil
    Carbohydr Res 338:1843-50. 2003
    ..acid hydrolysis gave 4-Me-alpha-GlcpA-(1-->2)-[beta-Xylp-(1-->4)](0-2)-Xyl, identified by showing that the uronic acids were single-unit side-chain substituents on O-2...
  21. ncbi Tandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides
    Joseph Zaia
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Am Soc Mass Spectrom 14:1270-81. 2003
    ..The capability of tandem MS to differentiate uronic acid epimers is also shown, providing evidence that complete or nearly complete information on CS covalent structure may be obtained using tandem MS...
  22. ncbi Structural analysis of the extracellular polysaccharide produced by Sphaerotilus natans
    Minoru Takeda
    Division of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National University, Kanagawa, Japan
    Biosci Biotechnol Biochem 66:1546-51. 2002
    ..natans is a new gellan-like polysaccharide constructed from a tetrasaccharide repeating unit, as shown below. -->4)-alpha-D-Glcp-(1-->2)-beta-D-GlcA p-(1-->2)-alpha-L-Rha p-(1-->3)-beta-L-Rha p-(1-->...
  23. ncbi Induction of necrosis factor-alpha and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids
    T Monodane
    Department of Microbiology and Immunology, Kagoshima University Dental School, Japan
    J Med Microbiol 50:4-12. 2001
    ..These findings suggest that induction of cytokines by teichuronic acids is mainly TLR4-dependent...
  24. pmc Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides
    Tulay Polat
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Am Chem Soc 129:12795-800. 2007
    ..L-Idopyranosyl and D-glucopyranosyl thioglycosides 5 and 10 were used as donors due to low reactivity of uronic acids as the glycosyl donors in the one-pot synthesis...
  25. ncbi Two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody WF6
    Peraphan Pothacharoen
    Thailand Excellence Center for Tissue Engineering, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Biol Chem 282:35232-46. 2007
    ....
  26. ncbi The antitumor and antioxidative activities of polysaccharides isolated from Isaria farinosa B05
    Yan Hua Jiang
    Institute of Food Science and Engineering, Division of Life Science and Technology, Ocean University of China, Qingdao, PR China
    Microbiol Res 163:424-30. 2008
    ..6:4.7:1.0. WIPS1 and WEPS1 had a molecular weight of 42 and 208kDa, respectively. The in vivo tests in mice indicate that WIPS1 and WEPS1 had significant antitumor and antioxidative activities to some extent...
  27. ncbi Structural differentiation of uronosyl substitution patterns in acidic heteroxylans by electrospray tandem mass spectrometry
    Ana Reis
    Department of Chemistry, University of Aveiro, Aveiro, Portugal
    J Am Soc Mass Spectrom 15:43-7. 2004
    ....
  28. ncbi Changes in cell wall composition associated with maturation in the gymnosperm Araucaria angustifolia
    Renato Bochicchio
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, C P 19046, CEP 81531 990, Curitiba, PR, Brazil
    Int J Biol Macromol 38:180-90. 2006
    ..The changes in cell wall composition suggest that the development in gymnosperm cell walls follow the same key events as found in dicotyledon walls (type I)...
  29. ncbi Electrospray ionization ion-trap multistage mass spectrometric study of sodium cationized aldobiuronic and pseudoaldobiuronic acid derivatives
    Vladimír Kovácik
    Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 84258 Bratislava, Slovakia
    J Mass Spectrom 39:1554-61. 2004
    ..In most cases they take place on the acidic part of the dimer and at the interglycosidic oxygen atom. As a result, the criteria for the differentiation of aldobiouronic and pseudoaldobiouronic acids derivatives were elucidated...
  30. ncbi Structure of aldobiouronic acid and glucuronic acid from Agathis australis degraded gum polysaccharide
    R B Singh
    Department of Zoology, School of Life Sciences, Dr B R Ambedkar University, Khandari Campus, Agra 282 002, India
    J Environ Biol 28:163-6. 2007
    ..The components of aldobiouronic acid and glucuronic acid were obtained by graded hydrolysis of degraded gum polysaccharide. The derivatives of aldobiouronic acid was obtained as methyl ester methyl glycoside...
  31. ncbi [Anionic polymers of the cell wall of Streptomyces sp. VKM An-2534]
    E M Tul'skaia
    Bioorg Khim 33:269-76. 2007
    ..The structures were proved by chemical and NMR spectroscopic methods. It is likely that the presence of acidic polysaccharides on the surface of the phytopathogenic streptomycete is necessary for its attachment to the host plant...
  32. ncbi The dual roles of AlgG in C-5-epimerization and secretion of alginate polymers in Pseudomonas aeruginosa
    Sumita Jain
    Department of Microbiology, Medical College of Virginia Campus of Virginia Commonwealth University, 1101 E Marshall St, Rm 5 051, Richmond, VA 23298 0678, USA
    Mol Microbiol 47:1123-33. 2003
    ..Instead of producing poly mannuronate, the algG deletion mutant secreted dialysable uronic acids, as does a mutant lacking the periplasmic protein AlgK...
  33. pmc Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues
    Takayoshi Yamada
    Department of Chemistry, Aichi University of Education, Igaya cho, Kariya, Aichi 448 8542, Japan
    Biochem J 384:567-75. 2004
    ..These results indicate that C4ST-1 and C6ST-1 differ from each other in the recognition of uronic acid residues adjacent to the targeted GalNAc residue...
  34. ncbi Effect of storage on wall-bound phenolics in green asparagus
    Rocio C Rodriguez-Arcos
    Institute of Food Research, Norwich Laboratory, Colney, Norwich NR4 7UA, United Kingdom
    J Agric Food Chem 50:3197-203. 2002
    ..The possible roles phenolic esters might have in relation to the mechanical, textural, and wound-response properties of asparagus spears are discussed...
  35. ncbi Isolation and characterization of structural components of Aloe vera L. leaf pulp
    Y Ni
    DelSite Biotechnologies lab c o Department of Veterinary Pathobiology, Texas A and M University, College Station, Texas 77843, USA
    Int Immunopharmacol 4:1745-55. 2004
    ..These findings may help lay a basis for further studies and development of better controlled processing methods and applications for this well-accepted medicinal plant...
  36. ncbi Effect of bitter gourd and spent turmeric on constituents of glycosaminoglycans in different tissues in streptozotocin induced diabetic rats
    G Suresh Kumar
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570 020, India
    Mol Cell Biochem 286:53-8. 2006
    ....
  37. ncbi Methyl esterification divergently affects the degradability of pectic uronosyls in nonlignified and lignified maize cell walls
    John H Grabber
    U S Dairy Forage Research Center, Agricultural Research Service, U S Department of Agriculture, 1925 Linden Drive West, Madison, Wisconsin 53706, USA
    J Agric Food Chem 53:1546-9. 2005
    ..Variations in uronosyl methylation had little effect on the overall release of total sugars from cell walls...
  38. ncbi Isolation and characterization of pectin from peel of Citrus tankan
    Yukihiro Tamaki
    The United Graduate School of Agricultural Science, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Biosci Biotechnol Biochem 72:896-9. 2008
    ..2%. The pectin was composed of D-GalA, D-Gal, L-Ara and L-Rha in the molar ratio of 100:11.3:3.6:2.6. The molecular weight was estimated to be approximately 9.2 x 10(4). The pectin formed a gel by conventional procedures...
  39. pmc Analysis of tomato polygalacturonase expression in transgenic tobacco
    K W Osteryoung
    Mann Laboratory, Department of Vegetable Crops, University of California, Davis 95616
    Plant Cell 2:1239-48. 1990
    ..However, accumulation of the two polygalacturonase isozymes expressed in this heterologous host was insufficient to promote polyuronide degradation in tobacco leaf tissue...
  40. ncbi A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy
    Jeroen D C Codée
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Am Chem Soc 127:3767-73. 2005
    ..The key 1-thio uronic acids were obtained in an efficient manner from diacetone glucose employing a chemo- and regioselective oxidation of ..
  41. ncbi Effects of stage of maturity and cooking on the chemical composition of select mushroom varieties
    Cheryl L Dikeman
    Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Agric Food Chem 53:1130-8. 2005
    ..Cooking increased starch, TDF, and AHF but decreased CP and chitin concentrations. The chitin concentration increased with mushroom maturity. These results detail the complete carbohydrate profile of several important mushroom varieties...
  42. ncbi Pectic methyl and nonmethyl esters in potato cell walls
    Iain M MacKinnon
    Chemistry Department, Glasgow University, Glasgow G12 8QQ, Scotland, UK
    J Agric Food Chem 50:342-6. 2002
    ....
  43. ncbi Acidic glycosaminoglycans in developing sterno-costal cartilage of the hydrocephalic (ch+-ch+) mouse
    M Breen
    Biochim Biophys Acta 304:828-36. 1973
  44. ncbi A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase
    Shiori Ohtake
    Department of Chemistry, Aichi University of Education, Igaya cho, Kariya, Aichi 448 8542, Japan
    J Biol Chem 278:38443-52. 2003
    ..Oligo III behaved identically with the sulfated Oligos I and II. These results suggest that GalNAc4S-6ST may be involved in the terminal modification of CS-A, through which a highly sulfated nonreducing terminal sequence is generated...
  45. ncbi Glycosaminoglycan content in skin of the tight-skin mouse
    S C Ross
    Arthritis Rheum 26:653-7. 1983
    ..Biochemical studies included determinations of hexosamines, uronic acids, and total GAGs by cetylpyridinium chloride precipitation...
  46. ncbi A facile preparation of uronates via selective oxidation with TEMPO/KBr/Ca(OCl)(2) under aqueous conditions
    Feng Lin
    State Key Laboratory of Bio organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
    Carbohydr Res 339:1219-23. 2004
    ..The beneficial effect of Aliquat 336 was also disclosed in the oxidation of certain substrates...
  47. ncbi Variability in the carbazole assay for N-desulfonated/N-acylated heparin derivatives
    Christopher M Hattan
    Division of Medicinal and Natural Products Chemistry, University of Iowa, Iowa City, IA 52242, United States
    Carbohydr Res 342:2664-9. 2007
    ....
  48. ncbi Molecular dynamics and atomic charge calculations in the study of heparin conformation in aqueous solution
    Camila F Becker
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Carbohydr Res 340:1499-507. 2005
    ..This information can be potentially of great relevance in the design of heparin-derived antithrombotic compounds...
  49. ncbi An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase
    Carl S Rye
    Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada
    Chembiochem 7:631-7. 2006
    ..In addition a structural and mechanistic rationale is provided for different active-site acid/base configurations in syn and anti lyases...
  50. ncbi Possible role of the polyuronic components in accumulation and mobilization of iron and phosphate at the soil--root interface
    Salvatore Deiana
    Dipartimento di Scienze Ambientali Agrarie e Biotecnologie Agroalimentari, Universita di Sassari, V le Italia 39, 07100 Sassari, Italy
    Plant Physiol Biochem 45:341-9. 2007
    ..Citric and malic acids showed to be active in the mobilization of both Fe and P whereas pyruvic acid appeared inactive...
  51. ncbi Purification and characterization of a beta-glucuronidase from Aspergillus niger
    H Kuroyama
    Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University, 255 Shimo-Okubo, Urawa 338-8570, Japan
    Carbohydr Res 333:27-39. 2001
    ..It released uronic acids not only from p-nitrophenyl beta-glucosiduronic acid (PNP-GlcA) but also from acidic galactooligosaccharides ..
  52. ncbi Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus
    Pilar Rupérez
    Departamento de Metabolismo y Nutricion, Instituto del Frio, Consejo Superior de Investigaciones Cientificas CSIC, Ciudad Universitaria s n, E 28040 Madrid, Spain
    J Agric Food Chem 50:840-5. 2002
    ..Soluble fractions (42.3% yield) were composed of neutral sugars (18.9-48 g/100 g), uronic acids (8.8-52.8 g/100 g), sulfate (2.4-11.5 g/100 g), small amounts of protein (< 1-6...
  53. ncbi Synthesis and evaluation of potential inhibitors of chondroitin AC lyase from Flavobacterium heparinum
    Carl S Rye
    Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada, V6T 1Z1
    J Org Chem 67:4505-12. 2002
    ..The anion of compound 2 was found to be a competitive inhibitor with a K(i) value of 5 mM, whereas the conjugate acid had a K(i) value of 35 mM...
  54. ncbi Galactosaminoglycan composition in chicken eggshell
    T Nakano
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada
    Poult Sci 81:709-14. 2002
    ..Results of chondroitinase-ABC digestion demonstrated 4-sulfated disaccharides to be the major repeating units in the chicken eggshell galactosaminoglycans...
  55. ncbi [Interaction of nucleic acids and glycans]
    A N Zimnitskiĭ
    Biofizika 52:443-51. 2007
    ..The data obtained suggest the existence of template synthesis of GAG polysaccharide fragments with the participation of NA...
  56. ncbi Fractional and structural characterization of hemicelluloses from perennial ryegrass (Lolium perenne) and cocksfoot grass (Dactylis glomerata)
    F Xu
    College of Material Science and Technology, Beijing Forestry University, Beijing 100083, China
    Carbohydr Res 341:2073-82. 2006
    ..4-38.2%), uronic acids (9.3-15.3%) and rhamnose (3.0-3.9%), but were lower in glucose (25.1-28.3%), galactose (13.3-15...
  57. ncbi Acacia senegal gum: continuum of molecular species differing by their protein to sugar ratio, molecular weight, and charges
    Denis Renard
    Unité de recherches Biopolymères, Interactions, Assemblages, INRA, rue de la Geraudiere, BP 71627 44316 Nantes Cedex 3, France
    Biomacromolecules 7:2637-49. 2006
    ..In addition, both sugars content (neutral and uronic acids) and UV profiles revealed that FIII was composed of a continuum of molecular species differing both by their ..
  58. ncbi Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis
    Simon Ballance
    School of Biological Sciences, University of Manchester, Manchester M13 9PL, UK
    Comp Biochem Physiol B Biochem Mol Biol 137:475-86. 2004
    ..of the glycopeptides is consistent with mucin-like molecules, there being no significant amounts of xylose or uronic acids. The residual 20% of the preparation, which apparently resisted reduction and protease digestion, had a similar ..
  59. ncbi Carbohydrate metabolism of eggs of the whitefish, Coregonus spp. during embryogenesis and its relationship with egg quality
    Franz Lahnsteiner
    Department for Organismic Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria
    Comp Biochem Physiol B Biochem Mol Biol 142:46-55. 2005
    ..Coregonus spp. eggs contained hexoses, ketoses, 6-deoxyhexoses, heptoses and uronic acids with hexoses, ketoses, and 6-deoxysugars occurring free and in bound form...
  60. ncbi Determination of saccharide content in pneumococcal polysaccharides and conjugate vaccines by GC-MSD
    John S Kim
    Wyeth Vaccine, Research and Development, 4300 Oak Park, Sanford, NC 27330, USA
    Anal Biochem 347:262-74. 2005
    ..Monosaccharides released during methanolysis included hexoses, uronic acids, 6-deoxy-hexoses, amino sugars, and alditols...
  61. ncbi Effect of procyanidolic oligomers of Vitis vinifera on the biosynthesis and excretion of corneal glycosaminoglycans
    A M Robert
    Laboratoire de Recherche Ophtalmologique, Hopital Hotel Dieu, Universite Paris 5, France
    Pathol Biol (Paris) 53:411-5. 2005
    ..This was accomplished by the determination of their chemical components, hexoses, hexosamines and uronic acids as well as the incorporation of (35)S-sulfate in the presence and without PCO in the culture medium...
  62. ncbi Ion chromatography characterization of polysaccharides in ancient wall paintings
    Maria Perla Colombin
    Dipartimento di Scienze dell Ambiente e del Territorio, University of Milano Bicocca, Milan, Italy
    J Chromatogr A 968:79-88. 2002
    ..separation of seven monosaccharides (fucose, rhamnose, arabinose, galactose, glucose, mannose, xylose) and two uronic acids (galacturonic and glucuronic) was achieved in 40 min...
  63. pmc Convergent evolution sheds light on the anti-beta -elimination mechanism common to family 1 and 10 polysaccharide lyases
    Simon J Charnock
    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, United Kingdom
    Proc Natl Acad Sci U S A 99:12067-72. 2002
    Enzyme-catalyzed beta-elimination of sugar uronic acids, exemplified by the degradation of plant cell wall pectins, plays an important role in a wide spectrum of biological processes ranging from the recycling of plant biomass through to ..
  64. ncbi Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability
    John Dowdle
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK
    Plant J 52:673-89. 2007
    Plants synthesize ascorbate from guanosine diphosphate (GDP)-mannose via L-galactose/L-gulose, although uronic acids have also been proposed as precursors...
  65. ncbi Characteristics of bioemulsifier V2-7 synthesized in culture media added of hydrocarbons: chemical composition, emulsifying activity and rheological properties
    F Martínez-Checa
    Microbial Exopolysaccharide Research Group, Department of Microbiology, Faculty of Pharmacy, University of Granada, Spain
    Bioresour Technol 98:3130-5. 2007
    ..Respect to chemical composition, percentage of uronic acids found in exopolymers produced in hydrocarbon media was always higher than that described for V2-7 EPS (1...
  66. ncbi Structural modification induced in heparin by a Fenton-type depolymerization process
    Elena Vismara
    G Natta Chemistry Department, Polytechnic of Milan, V Mancinelli 7, 20131 Milan, Italy
    Semin Thromb Hemost 33:466-77. 2007
    ..Natural uronic acids, especially the 2- O-sulfate iduronic acid (I (2S)), are also present as reducing residues...
  67. pmc Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88
    Md Motarab Hossain
    Section of Pathophysiology and Neurobiology, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Glycobiology 20:175-86. 2010
    ..The state of sulfation in glucosamines and uronic acids within the chains strongly influences their binding...
  68. ncbi Analysis of carbohydrates in wood and pulps employing enzymatic hydrolysis and subsequent capillary zone electrophoresis
    O Dahlman
    Swedish Pulp and Paper Research Institute, Stockholm
    J Chromatogr A 891:157-74. 2000
    ..All reducing sugars (i.e., neutral monosaccharides and uronic acids) which occur as structural elements in the polysaccharides of wood and pulp can be quantitated in a single such ..
  69. ncbi Inhibition of croton oil-induced oedema in mice ear skin by capsular polysaccharides from cyanobacteria
    N Garbacki
    Laboratoire de Pharmacognosie, Institut de Pharmacie, CHU, Tour 4, Universite de Liege, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 361:460-4. 2000
    ..Analysis of five of the extracts showed the presence of neutral sugars (from 34.3% to 47.1%, w/w), uronic acids (from 7.1% to 26.7%, w/w) and proteins (from 30.1% to 57.0%, w/w) in the crude polymer...
  70. ncbi Structure and chemical composition of the cell walls from the haploid yeast and mycelial forms of Ustilago maydis
    J Ruiz-Herrera
    Department of Genética y Biología Molecular, Unidad México, D F, Mexico
    Fungal Genet Biol 20:133-42. 1996
    ..No chitosan or uronic acids were detected...
  71. doi Analysis of microbial extracellular polysaccharides in biofilms by HPLC. Part I: Development of the analytical method using two complementary stationary phases
    Stefan Meisen
    Instrumental Analytical Chemistry, University of Duisburg Essen, Lotharstr 1, 47057, Duisburg, Germany
    Anal Bioanal Chem 391:993-1002. 2008
    ..A procedure for the qualitative and quantitative determination of various monosaccharides, oligosaccharides and uronic acids as important components of the carbohydrate fraction of microbial EPS by high-performance liquid chromatography ..
  72. doi Polysaccharides from the skin of the ray Raja radula. Partial characterization and anticoagulant activity
    Mohamed Ben Mansour
    Laboratoire de Pharmacologie 04 UR 01 09, Faculte de Medecine, Monastir, Tunisia
    Thromb Res 123:671-8. 2009
    ..The polysaccharide fraction from the skin of the ray Raja radula was extracted, characterized and assayed for anticoagulant activity...
  73. doi Occurrence and composition of extracellular lipids and polysaccharides in a full-scale membrane bioreactor
    Djamila Al-Halbouni
    Institute of Hygiene and Environmental Health, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Water Res 43:97-106. 2009
    ..Photometric analysis of sugars showed that uronic acids (glucuronic, mannuronic and galacturonic acid) as common units of bacterial polysaccharides accounted for 8% (w/..
  74. ncbi [Polar components of Black sea seaweed Colpomenia peregrina (Sauv.) Hamel]
    A I Usov
    Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr 47, GSP Moscow, 119991 Russia
    Bioorg Khim 30:182-9. 2004
    ..a complex heteropolysaccharide containing, in addition to fucose and sulfate, other neutral monosaccharides and uronic acids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no...
  75. ncbi Expression of UDP-glucose dehydrogenase reduces cell-wall polysaccharide concentration and increases xylose content in alfalfa stems
    Deborah A Samac
    USDA ARS Plant Science Research, 495 Borlaug Hall, 1991 Upper Buford Circle, University of Minnesota, St Paul, MN 55108, USA
    Appl Biochem Biotechnol 113:1167-82. 2004
    The primary cell-wall matrix of most higher plants is composed of large amounts of uronic acids, primarily D-galacturonic acid residues in the backbone of pectic polysaccharides...
  76. ncbi Effect of polysaccharide from Auricularia auricula on blood lipid metabolism and lipoprotein lipase activity of ICR mice fed a cholesterol-enriched diet
    G Chen
    College of Food Science and Nutritional Engineering, China Agricultural Univ, Beijing, China
    J Food Sci 73:H103-8. 2008
    ..5% total carbohydrate, 19.6% uronic acids, 15.8% sulfate groups, 1.7% N, and 20.3% ash...
  77. ncbi Enhancement of nitrifying biofilm formation using selected EPS produced by heterotrophic bacteria
    S Tsuneda
    Department of Chemical Engineering, Waseda University, 3 4 1 Ohkubo, Shinjuku ku, Tokyo 169 8555, Japan
    Water Sci Technol 43:197-204. 2001
    ..Among EPS components, the concentration of uronic acids gave a good correlation with flocculation ability, which suggests that acidic polysaccharides play a major role ..
  78. doi Differences in carbohydrate profiles in batch culture grown planktonic and biofilm cells of Amphora rostrata Wm. Sm
    Vishwas B Khodse
    National Institute of Oceanography, Dona Paula, Goa, India
    Biofouling 26:527-37. 2010
    ..two modes of growth, the concentration of total carbohydrates, carbohydrate fractions, neutral carbohydrates, uronic acids and amino sugars in planktonic and biofilm cells of Amphora rostrata were measured...
  79. ncbi Microbial signature lipid profiling and exopolysaccharides: experiences initiated with Professor David C White and transported to Tasmania, Australia
    Peter D Nichols
    CSIRO Marine and Atmospheric Research, CSIRO Food Futures Flagship, GPO Box 1538, Hobart, Tasmania 7000, Australia
    J Microbiol Methods 74:33-46. 2008
    ..pollutant halogenated hydrocarbons in groundwater and subsurface aquifers; exploiting the ubiquitous nature of uronic acids in microbial EPS to quantify these exopolymers in complex environmental samples; development of rapid and non-..
  80. pmc Bacterial exopolysaccharides from extreme marine habitats: production, characterization and biological activities
    Annarita Poli
    Institute of Biomolecular Chemistry, C N R, Via Campi Flegrei 34, Pozzuoli, Naples, Italy
    Mar Drugs 8:1779-802. 2010
    ..Some EPS are neutral macromolecules, but the majority of them are polyanionic for the presence of uronic acids or ketal-linked pyruvate or inorganic residues such as phosphate or sulfate...
  81. ncbi Effect of germination on the carbohydrate composition of the dietary fiber of peas (Pisum sativum L.)
    María A Martín-Cabrejas
    Departamento de Quimica Agricola, Facultad de Ciencias, Universidad Autonoma de Madrid UAM, Spain
    J Agric Food Chem 51:1254-9. 2003
    ..IDF) and soluble dietary fiber (SDF) were subjected to acid hydrolysis, and the resultant neutral sugars, uronic acids, and Klason lignin were quantified...
  82. ncbi Extracellular polymeric substances mediate bioleaching/biocorrosion via interfacial processes involving iron(III) ions and acidophilic bacteria
    Wolfgang Sand
    Universitat Duisburg Essen, Biofilm Centre, Aquatische Biotechnologie, Geibelstrasse 41, D 47057 Duisburg, Germany
    Res Microbiol 157:49-56. 2006
    ..mediate attachment to a (metal) sulfide surface, and (ii) to concentrate iron(III) ions by complexation through uronic acids or other residues at the mineral surface, thus, allowing an oxidative attack on the sulfide...
  83. doi In vitro anti-adhesive activity of green tea extract against pathogen adhesion
    Ji Hye Lee
    Department of Food Technology, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Phytother Res 23:460-6. 2009
    ..CSI-4) with the maximum yield of 4% (w/v) is composed of a major proportion of carbohydrates containing 40% uronic acids, but lack of catechins...
  84. ncbi Functional characterization of D-galacturonic acid reductase, a key enzyme of the ascorbate biosynthesis pathway, from Euglena gracilis
    Takahiro Ishikawa
    Department of Life and Environmental Sciences, Shimane University, Nishikawatsu, Matsue, Shimane, Japan
    Biosci Biotechnol Biochem 70:2720-6. 2006
    ..Apparently it utilized NADPH with a Km value of 62.5+/-4.5 microM and uronic acids, such as D-galacturonic acid (Km=3.79+/-0.5 mM) and D-glucuronic acid (Km=4.67+/-0.6 mM)...
  85. doi Bioflocculant exopolysaccharide production by Azotobacter indicus using flower extract of Madhuca latifolia L
    Satish V Patil
    School of Life Sciences, North Maharashtra University, Post Box 80, Jalgaon 425001, Maharashtra, India
    Appl Biochem Biotechnol 162:1095-108. 2010
    ..polymer was characterized by different chemical tests, FT-IR spectroscopy, and TLC which showed presence of uronic acids, O-acetyl groups, and Orcinol with suggestive indication of alginate like polymer...
  86. ncbi Glycoprotein emulsifiers from two marine Halomonas species: chemical and physical characterization
    T Gutierrez
    Microbial and Molecular Biology Department, Scottish Association for Marine Science, Dunstaffnage Marine Laboratory, Oban, Scotland, UK
    J Appl Microbiol 103:1716-27. 2007
    ..To partially purify and characterize bioemulsifiers produced by two new marine Halomonas species, TG39 and TG67, and to compare their emulsifying activities with those of commercial emulsifiers...
  87. doi Physiological and biochemical investigations on egg stickiness in common carp
    N Mansour
    Department of Organismic Biology, Faculty of Natural Sciences, University of Salzburg, Hellbrunnerstr 34, A 5020 Salzburg, Austria
    Anim Reprod Sci 114:256-68. 2009
    ..Glucose, fructose, galactose, and uronic acids were the major carbohydrates...
  88. pmc The pathway via D-galacturonate/L-galactonate is significant for ascorbate biosynthesis in Euglena gracilis: identification and functional characterization of aldonolactonase
    Takahiro Ishikawa
    Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane 690 8504, Japan
    J Biol Chem 283:31133-41. 2008
    ..The identification of aldonolactonase provides the first insight into the biosynthesis of AsA via uronic acids as the intermediate in photosynthetic algae including Euglena.
  89. pmc Overexpression of pectin methylesterase inhibitors in Arabidopsis restricts fungal infection by Botrytis cinerea
    Vincenzo Lionetti
    Dipartimento di Biologia Vegetale, Universita di Roma La Sapienza, 00185 Rome, Italy
    Plant Physiol 143:1871-80. 2007
    ..While the content of uronic acids in transformed plants was not significantly different from that of wild type, the degree of pectin ..
  90. ncbi Digestibility by dairy cows of monosaccharide constituents in total mixed rations containing citrus pulp
    J Miron
    Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
    J Dairy Sci 85:89-94. 2002
    ..Across treatments, neutral detergent fiber (NDF) glucose was more digestible than NDF xylose and uronic acids and less digestible than NDF arabinose, galactose, and mannose...
  91. doi GC/MS analytical procedure for the characterization of glycerolipids, natural waxes, terpenoid resins, proteinaceous and polysaccharide materials in the same paint microsample avoiding interferences from inorganic media
    Anna Lluveras
    Laboratory of Chemical Science for Safeguarding the Cultural Heritage, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy
    Anal Chem 82:376-86. 2010
    ..and analyzed separately by GC/MS, thus enabling a quantitative analysis to be performed on aldoses and uronic acids, amino acids, mono- and dicarboxylic aliphatic acids, to determine polysaccharide, proteinaceous, and ..
  92. doi Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module
    Márcia A S Correia
    CIISA, Faculdade de Medicina Veterinaria, Pólo Universitário do Alto da Ajuda, Avenida da Universidade Tecnica, 1300 477 Lisboa, Portugal
    Biochemistry 49:6193-205. 2010
    ..binding site of the CBM displays significant structural similarity with calcium-dependent CBM35s that target uronic acids, subtle differences in the conformation of conserved residues in the ligand binding site lead to the loss of ..
  93. doi Optimization of the extraction of anthocyanin from Bokbunja (Rubus coreanus Miq.) marc produced during traditional wine processing and characterization of the extracts
    C S Ku
    Department of Advanced Organic Materials Engineering, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
    Bioresour Technol 99:8325-30. 2008
    ..and pectin) in Bokbunja marc underwent significant variation toward the formation of by-products (glycerol and uronic acids) during yeast fermentation, and that the amount of anthocyanin produced was reduced 10-fold when compared to ..
  94. ncbi Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta)
    Betty Matsuhiro
    Departamento de Ciencias Quimicas, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Casilla 40, Santiago 33, Chile
    Carbohydr Res 340:2392-402. 2005
    ..0:0.89 together with uronic acids (6.8 wt%) and minor amounts of other neutral sugars...
  95. doi Changes in polysaccharide and protein composition of cell walls in grape berry skin (Cv. Shiraz) during ripening and over-ripening
    Anysia Vicens
    INRA, UMR 1083, F 34060 Montpellier, France
    J Agric Food Chem 57:2955-60. 2009
    ..content of insoluble polysaccharides was observed, as well as a significant de-esterification of methoxylated uronic acids, indicating that some modifications occur in cell wall polysaccharides...
  96. ncbi Comparison of the complexation potential of extracellular polymeric substances (EPS), extracted from activated sludges and produced by pure bacteria strains, for cadmium, lead and nickel
    Gilles Guibaud
    Laboratoire des Sciences de l Eau et de l Environnement, Faculte des Sciences et Techniques, Universite de Limoges, 123, Avenue Albert Thomas, 87060 Limoges Cedex, France
    Chemosphere 59:629-38. 2005
    ..extracted from pure bacteria cultures are mainly composed of proteins and low quantities of polysaccharides and uronic acids in comparison with EPS extracted from activated sludges...
  97. doi Characterization of the cell wall of the ubiquitous plant pathogen Botrytis cinerea
    Dario Cantu
    Department of Plant Sciences, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Mycol Res 113:1396-403. 2009
    ..Neutral sugars and proteins constituted most of the mass of the B. cinerea cell walls, although chitin and uronic acids were detected...
  98. doi Brown algae overproduce cell wall polysaccharides as a protection mechanism against the heavy metal toxicity
    Leonardo R Andrade
    Laboratório de Biomineralização, Instituto de Ciencias Biomedicas, CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, 21941 590 Rio de Janeiro, RJ, Brazil
    Mar Pollut Bull 60:1482-8. 2010
    ..We found that raw dried polysaccharides, sulfate groups, uronic acids, fucose, mannose, and galactose were significantly higher in contaminated algae compared with the control ones...
  99. doi Application and comparison of four selected procedures for the isolation of cell-wall material from the skin of grapes cv. Monastrell
    R Apolinar-Valiente
    Departamento de Tecnologia de Alimentos, Nutricion y Bromatologia, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Anal Chim Acta 660:206-10. 2010
    ..Regarding the carbohydrates composition, the four different CWM were rich in uronic acids and glucose, together with varying amounts of arabinose, xylose, mannose and galactose...
  100. pmc Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice
    Nadine Hoffmann
    Department of Clinical Microbiology, Rigshospitalet, Institute for Medical Microbiology and Immunology, Panum Institute 24 1, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Antimicrob Agents Chemother 51:3677-87. 2007
    ..alginate by the incomplete precipitation of polymerized alginate and high levels of readily dialyzable uronic acids. In addition, we find that mucoid bacteria in the stationary growth phase became sensitive to AZM, whereas ..
  101. ncbi An arabinogalactan-protein from cell culture of Malva sylvestris
    Birgit Classen
    Pharmazeutisches Institut der Christian Albrechts Universität Kiel, Abteilung Pharmazeutische Biologie, Kiel, Germany
    Planta Med 68:232-6. 2002
    ..9 : 1, some uronic acids, and a small protein moiety with the main amino acids serine, alanine and hydroxyproline...

Research Grants13

  1. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
    ..abstract_text> ..
  2. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
    ..The costs of instrument operation, supplies, and service contract will be shared by the users, as stated in their support letters. The salary for the instrument operator will be provided by the Dean of BU School of Medicine. ..
  3. Post-biosynthetic remodeling of heparan sulfate
    Joseph Zaia; Fiscal Year: 2010
    ..This research will explore the structure-function relationships of vascular heparan sulfates in order to inform efforts to develop protein binding microarrays, drugs and therapeutics. ..
  4. An in-situ gelling nasal vaccine delivery platform
    YAWEI NI; Fiscal Year: 2005
    ..These studies will form the basis for phase II development of this platform targeting demonstration of safety and efficacy against selected pathogens that have significant unmet medical and biodefense needs in humans. ..
  5. An Inactivated Influenza Nasal Powder Vaccine
    YAWEI NI; Fiscal Year: 2004
    ..Completion of these preclinical studies will form the basis for an IND submission. ..