sorbitol

Summary

Summary: A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

Top Publications

  1. pmc TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor
    Colleen M Dewey
    Department of Neuroscience, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Mol Cell Biol 31:1098-108. 2011
  2. ncbi Plasmolysis effects and osmotic potential of two phylogenetically distinct alpine strains of Klebsormidium (Streptophyta)
    Franziska Kaplan
    Institute of Botany, Functional Plant Biology, University of Innsbruck, Sternwartestrasse 15, 6020, Innsbruck, Austria
    Protoplasma 249:789-804. 2012
  3. ncbi Cryoprotective role of polyols independent of the increase in supercooling capacity in diapausing adults of Pyrrhocoris apterus (Heteroptera: Insecta)
    V Kost'ál
    Institute of Entomology, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic
    Comp Biochem Physiol B Biochem Mol Biol 130:365-74. 2001
  4. pmc Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
    G Bhanuprakash Reddy
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India
    Mol Vis 14:593-601. 2008
  5. pmc OSM1/SYP61: a syntaxin protein in Arabidopsis controls abscisic acid-mediated and non-abscisic acid-mediated responses to abiotic stress
    Jianhua Zhu
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 1165, USA
    Plant Cell 14:3009-28. 2002
  6. ncbi Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris
    Ramon Ramon
    Departament d Enginyeria Quimica, ETSE, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Biotechnol 130:39-46. 2007
  7. ncbi Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive D-galactose pathway and essential for D-sorbitol catabolism
    Outi M Koivistoinen
    VTT Technical Research Centre of Finland, Finland
    FEBS Lett 586:378-83. 2012
  8. ncbi In vitro screening of potato against water-stress mediated through sorbitol and polyethylene glycol
    Jai Gopal
    Crop Science Laboratory, Research Faculty of Agriculture, Hokkaido University, Sapporo, 060 8589 Japan
    Plant Cell Rep 26:693-700. 2007
  9. ncbi Testing polyols' compatibility with Gibbs energy of stabilization of proteins under conditions in which they behave as compatible osmolytes
    Inamul Haque
    Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India
    FEBS Lett 579:3891-8. 2005
  10. ncbi Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea
    Eleni Mavrogonatou
    Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research Demokritos, Athens, Greece
    J Cell Physiol 227:1179-87. 2012

Detail Information

Publications282 found, 100 shown here

  1. pmc TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor
    Colleen M Dewey
    Department of Neuroscience, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Mol Cell Biol 31:1098-108. 2011
    ..In this study, we establish sorbitol as a novel physiological stressor that directs TDP-43 to stress granules in Hek293T cells and primary cultured ..
  2. ncbi Plasmolysis effects and osmotic potential of two phylogenetically distinct alpine strains of Klebsormidium (Streptophyta)
    Franziska Kaplan
    Institute of Botany, Functional Plant Biology, University of Innsbruck, Sternwartestrasse 15, 6020, Innsbruck, Austria
    Protoplasma 249:789-804. 2012
    ..investigated in two different Klebsormidium strains from alpine habitats by incubation in 300-2,000 (3,000) mM sorbitol. Several members of this genus were previously found to tolerate desiccation in the vegetative state yet ..
  3. ncbi Cryoprotective role of polyols independent of the increase in supercooling capacity in diapausing adults of Pyrrhocoris apterus (Heteroptera: Insecta)
    V Kost'ál
    Institute of Entomology, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic
    Comp Biochem Physiol B Biochem Mol Biol 130:365-74. 2001
    Diapausing cold-acclimated adults of the bug Pyrrhocoris apterus accumulate four 'winter' polyols, ribitol, sorbitol, mannitol and arabinitol, in total concentrations of up to 100 mM...
  4. pmc Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
    G Bhanuprakash Reddy
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India
    Mol Vis 14:593-601. 2008
    ..We investigated the relationship between ALR2 levels and human DR by measuring ALR2 activity and its product, sorbitol, in erythrocytes.
  5. pmc OSM1/SYP61: a syntaxin protein in Arabidopsis controls abscisic acid-mediated and non-abscisic acid-mediated responses to abiotic stress
    Jianhua Zhu
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 1165, USA
    Plant Cell 14:3009-28. 2002
    ..Together, our results demonstrate important roles of OSM1/SYP61 in osmotic stress tolerance and in the ABA regulation of stomatal responses...
  6. ncbi Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris
    Ramon Ramon
    Departament d Enginyeria Quimica, ETSE, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Biotechnol 130:39-46. 2007
    ..pastoris, the effect of sorbitol/methanol mixed substrates was tested in batch and fed-batch cultures...
  7. ncbi Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive D-galactose pathway and essential for D-sorbitol catabolism
    Outi M Koivistoinen
    VTT Technical Research Centre of Finland, Finland
    FEBS Lett 586:378-83. 2012
    ..pathway D-galactose is converted to d-fructose in a series of steps where the last step is the oxidation of d-sorbitol by an NAD-dependent dehydrogenase...
  8. ncbi In vitro screening of potato against water-stress mediated through sorbitol and polyethylene glycol
    Jai Gopal
    Crop Science Laboratory, Research Faculty of Agriculture, Hokkaido University, Sapporo, 060 8589 Japan
    Plant Cell Rep 26:693-700. 2007
    ..Different levels of water-stress were induced using five concentrations of either sorbitol or polyethylene glycol (PEG) in MS medium. Water potential of various media ranged from -0.80 MPa to -2.05 MPa...
  9. ncbi Testing polyols' compatibility with Gibbs energy of stabilization of proteins under conditions in which they behave as compatible osmolytes
    Inamul Haque
    Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India
    FEBS Lett 579:3891-8. 2005
    ..of the activity parameters (K(m) and k(cat)) and guanidinium chloride-induced denaturations of lysozyme and ribonuclease-A in the presence of five polyols (sorbitol, glycerol, mannitol, xylitol and adonitol) at pH 7.0 and 25 degrees C.
  10. ncbi Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea
    Eleni Mavrogonatou
    Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research Demokritos, Athens, Greece
    J Cell Physiol 227:1179-87. 2012
    ..the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea...
  11. pmc Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats
    Paduru Yadagiri Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    Mol Vis 18:495-503. 2012
    ....
  12. ncbi Detection of sorbitol-negative and sorbitol-positive Shiga toxin-producing Escherichia coli, Listeria monocytogenes, Campylobacter jejuni, and Salmonella spp. in dairy farm environmental samples
    S E Murinda
    Food Safety Center of Excellence, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Foodborne Pathog Dis 1:97-104. 2004
    ..Campylobacter jejuni, Salmonella spp., L. monocytogenes, Sorbitol-negative (SN)-STEC O157:H7, and sorbitol-positive (SP)-STEC, respectively, were isolated from 5.06%, 3.76%, 6...
  13. ncbi Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children
    K Alpers
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Epidemiol Infect 137:389-95. 2009
    An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002...
  14. ncbi Osmoregulation of aldose reductase and sorbitol dehydrogenase in cultivated interstitial cells of rat renal inner medulla
    Jurgen Steffgen
    Abteilung Nephrologie und Rheumatologie, Georg August Universitat Gottingen, Gottingen, Germany
    Nephrol Dial Transplant 18:2255-61. 2003
    Little is known about sorbitol metabolism in renal papillary interstitial cells...
  15. ncbi Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes
    Shinjiro Amano
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 830 0011, Kurume, Japan
    Biochem Biophys Res Commun 299:183-8. 2002
    The polyol pathway consists of two enzymes, aldose reductase (AR) and sorbitol dehydrogenase (SDH)...
  16. pmc Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase
    Mario Klimacek
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12 I, A 8010 Graz, Austria
    Biochem J 404:421-9. 2007
    Co-ordination of catalytic Zn2+ in sorbitol/xylitol dehydrogenases of the medium-chain dehydrogenase/reductase superfamily involves direct or water-mediated interactions from a glutamic acid residue, which substitutes a homologous ..
  17. ncbi Sorbitol-fermenting, β-glucuronidase-positive, Shiga toxin-negative Escherichia coli O157:H7 in free-ranging red deer in South-Central Spain
    Sandra Diaz
    Instituto de Investigacion en Recursos Cinegeticos, CSIC UCLM JCCM, Ciudad Real, Spain
    Foodborne Pathog Dis 8:1313-5. 2011
    ..coli O157:H7 in free-ranging red deer in south-central Spain, to assess their potential as reservoir hosts of sorbitol-fermenting (SF) E. coli O157:H7 strains, which are emerging causes of hemolytic uremic syndrome in Europe...
  18. pmc Chromosomal dynamism in progeny of outbreak-related sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM
    Martina Bielaszewska
    Institut fur Hygiene, Universitat Munster, Robert Koch Str 41, 48149 Munster, Germany
    Appl Environ Microbiol 72:1900-9. 2006
    b>Sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:NM (nonmotile) is a unique clone that causes outbreaks of hemorrhagic colitis and hemolytic-uremic syndrome...
  19. ncbi Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
    ..Both low and high doses of fidarestat (i.e., the doses that partially and completely inhibited sorbitol pathway hyperactivity) arrested diabetes-induced retinal lipid peroxidation...
  20. ncbi Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    Zeina Dagher
    Harvard Medical School, Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 53:2404-11. 2004
    The polyol (sorbitol) pathway of glucose metabolism is activated in many cell types when intracellular glucose concentrations are high, and it can generate cellular stress through several mechanisms...
  21. pmc Identification of common subpopulations of non-sorbitol-fermenting, beta-glucuronidase-negative Escherichia coli O157:H7 from bovine production environments and human clinical samples
    Zhijie Yang
    Department of Food Science and Technology, University of Nebraska, Lincoln, Nebraska 68583 0919, USA
    Appl Environ Microbiol 70:6846-54. 2004
    Non-sorbitol-fermenting, beta-glucuronidase-negative Escherichia coli O157:H7 strains are regarded as a clone complex, and populations from different geographical locations are believed to share a recent common ancestor...
  22. pmc Recycling of Shiga toxin 2 genes in sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM
    Alexander Mellmann
    Institute of Hygiene, University of Munster, Robert Koch Str 41, 48149 Munster, Germany
    Appl Environ Microbiol 74:67-72. 2008
    ..eae probes and agglutination in anti-O157 lipopolysaccharide serum, we isolated stx(2)-positive and eae-positive sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:NM (nonmotile) strains from initial stool ..
  23. ncbi Novel differential and confirmation plating media for Shiga toxin-producing Escherichia coli serotypes O26, O103, O111, O145 and sorbitol-positive and -negative O157
    Björn Possé
    Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium
    FEMS Microbiol Lett 282:124-31. 2008
    ..A second differential medium was designed for both sorbitol-positive and -negative O157 STEC strains...
  24. ncbi Gene expression profiles and intracellular contents of stress protectants in Saccharomyces cerevisiae under ethanol and sorbitol stresses
    Tomohiro Kaino
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Appl Microbiol Biotechnol 79:273-83. 2008
    ..When yeast cells were exposed to 1 M sorbitol stress, the expression of GPD1 encoding glycerol-3-phosphate dehydrogenase is induced, leading to glycerol ..
  25. pmc Isolation and characterization of Schizosaccharomyces pombe mutants defective in cell wall (1-3)beta-D-glucan
    J C Ribas
    Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Cientificas, Facultad de Biologia, Universidad de Salamanca, Spain
    J Bacteriol 173:3456-62. 1991
    ..It is concluded that the cwg1+ and cwg2+ genes are related to (1,3)beta-D-glucan biosynthesis...
  26. ncbi A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris
    Carmen Jungo
    Ecole Polytechnique Federale de Lausanne, Laboratoire de Génie Chimique et Biologique, Station 6, Lausanne, Switzerland
    J Biotechnol 131:57-66. 2007
    The advantages of mixed feeds of sorbitol and methanol for the production of recombinant proteins with Pichia pastoris were analyzed quantitatively...
  27. ncbi Effect of glucose on assimilatory sulphate reduction in Arabidopsis thaliana roots
    Holger Hesse
    Max Planck Institute for Molecular Plant Physiology, Department of Molecular Physiology, Am Muehlenberg 1, D 14476 Golm, Germany
    J Exp Bot 54:1701-9. 2003
    ..Treatment of roots with d-sorbitol or d-mannitol did not increase APR activity, indicating that osmotic stress was not involved in APR regulation...
  28. ncbi Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth
    G Nucera
    Internal Medicine Department, Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy
    Aliment Pharmacol Ther 21:1391-5. 2005
    Small intestinal bacterial overgrowth and sugar malabsorption (lactose, fructose, sorbitol) may play a role in irritable bowel syndrome...
  29. ncbi Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol
    Anita S Galvez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago 6640750, Chile
    J Biol Chem 278:38484-94. 2003
    Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death...
  30. ncbi A model system for increasing the intensity of whole-cell biocatalysis: investigation of the rate of oxidation of D-sorbitol to L-sorbose by thin bi-layer latex coatings of non-growing Gluconobacter oxydans
    M Fidaleo
    Biotechnology Institute, University of Minnesota, 140 Gortner Laboratories, 1479 Gortner Avenue, St Paul, 55108, USA
    Biotechnol Bioeng 95:446-58. 2006
    ..The oxidation of D-sorbitol to L-sorbose was used to investigate the coating catalytic properties...
  31. ncbi Turgor pressure regulation and the orientation of cortical microtubules in Spirogyra cells
    K Iwata
    Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, 573-0101 Japan
    Plant Cell Physiol 42:594-8. 2001
    ..5 h, 0.25 M. Similar changes in MT orientation and recovery of the turgor pressure were also observed in 0.30 M sorbitol solution. These results suggest that the MT orientation may be correlated with the turgor pressure...
  32. ncbi Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells
    Kanchanamala Withanage
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Biochem 152:111-9. 2012
    ..We demonstrated that RASSF6 as well as the Hippo pathway are involved in the sorbitol-induced apoptosis in immortalized human proximal renal tubular epithelial HK-2 cells.
  33. ncbi Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications
    Megha Saraswat
    National Institute of Nutrition, Hyderabad, India
    Asia Pac J Clin Nutr 17:558-65. 2008
    ..in high glucose containing medium was used to underscore the significance in terms of prevention of intracellular sorbitol accumulation...
  34. ncbi Spray-drying of proteins: effects of sorbitol and trehalose on aggregation and FT-IR amide I spectrum of an immunoglobulin G
    Michael Maury
    Department of Pharmaceutics, Friedrich Alexander University, Erlangen, Germany
    Eur J Pharm Biopharm 59:251-61. 2005
    ..The IgG solution contains initially 115 mg/ml IgG plus 50 mg/ml sorbitol. After dialysis, at least 80% of low molecular weight component was removed...
  35. ncbi Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol
    Paduru Yadagiri Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    IUBMB Life 65:472-8. 2013
    ..Previously we had demonstrated accumulation of sorbitol in the lens of obese rats (WNIN/Ob) and more so in a related strain with impaired glucose tolerance (WNIN/GR-Ob)...
  36. ncbi Identification of the anti-terminator qO111:H)- gene in Norwegian sorbitol-fermenting Escherichia coli O157:NM
    Kjersti Haugum
    Department of Foodborne Infections, The Norwegian Institute of Public Health, Oslo, Norway
    FEMS Microbiol Lett 329:102-10. 2012
    b>Sorbitol-fermenting Escherichia coli O157:NM (SF O157) is an emerging pathogen suggested to be more virulent than nonsorbitol-fermenting Escherichia coli O157:H7 (NSF O157)...
  37. ncbi Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues
    Yeon Sil Lee
    Seokwon Life Science Research Institute, World Sea Green Co Ltd, Paju 413 832, Korea
    Biol Pharm Bull 28:916-8. 2005
    ..inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated...
  38. ncbi Sorbitol production from lactose by engineered Lactobacillus casei deficient in sorbitol transport system and mannitol-1-phosphate dehydrogenase
    Reinout De Boeck
    Laboratorio de Bacterias Lacticas y Probioticos, IATA CSIC, P O Box 73, 46100 Burjassot Valencia, Spain
    Appl Microbiol Biotechnol 85:1915-22. 2010
    b>Sorbitol is a sugar alcohol largely used in the food industry as a low-calorie sweetener...
  39. ncbi Quantitative determination of endogenous sorbitol and fructose in human erythrocytes by atmospheric-pressure chemical ionization LC tandem mass spectrometry
    H R Liang
    Tandem Labs, A Division of NWT Inc, Salt Lake City, UT, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 824:36-44. 2005
    Evaluation of different extraction methods for quantification of endogenous sorbitol and fructose in human red blood cells (RBCs) and matrix effects in ESI and APCI showed that protein-precipitation followed by mixed-mode solid-phase ..
  40. ncbi Effectiveness of the sorbitol H2 breath test in detecting histological damage among relatives of coeliacs
    A Tursi
    Dept of Emergency, L Bonomo Hospital, Andria BA, Italy
    Scand J Gastroenterol 38:727-31. 2003
    ..The aim of this study was to compare the effectiveness of the sorbitol H2 breath test (H2-BT) and serological tests (antigliadin (AGA), antiendomysium (EMA) and anti-tissue ..
  41. ncbi Enhancement of cell viability and alkaline polygalacturonate lyase production by sorbitol co-feeding with methanol in Pichia pastoris fermentation
    Zhihao Wang
    Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122 Jiangsu, China
    Bioresour Technol 101:1318-23. 2010
    ..In order to enhance cell viability and volumetric recombinant protein productivity, sorbitol, which had been confirmed to be a non-repressive carbon source, was added together with methanol during the ..
  42. ncbi Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress
    Rujun Kang
    Department of Microbiology and Immunology, University of British Columbia, 300 6174 University Blvd, Vancouver, BC V6T 1Z3, Canada
    J Cell Sci 115:3675-82. 2002
    ..The accumulation of cGMP in response to 0.4 M sorbitol was reduced after rapA antisense RNA induction and was enhanced in cells expressing the constitutively activated ..
  43. ncbi Cryopreservation of boar semen by egg yolk-based extenders containing lactose or fructose is better than sorbitol
    Panida Chanapiwat
    Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Vet Med Sci 74:351-4. 2012
    The present study determined the effect of different types of sugars (lactose, fructose, glucose and sorbitol) used in egg yolk-based extender on the post-thawed boar semen quality...
  44. ncbi Herpes simplex virus type 2 US3 blocks apoptosis induced by sorbitol treatment
    Takayuki Murata
    Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Microbes Infect 4:707-12. 2002
    ..cells, we examined whether expression of US3 is sufficient to protect cells from apoptotic cell death induced by sorbitol. Cells expressing US3 showed significantly reduced nuclear fragmentation in the degree that DNA fragmentation and ..
  45. ncbi Evaluation of a multiplex-PCR detection in combination with an isolation method for STEC O26, O103, O111, O145 and sorbitol fermenting O157 in food
    K Verstraete
    Institute for Agricultural and Fisheries Research ILVO, Technology and Food Science Unit, Brusselsesteenweg 370, 9090 Melle, Belgium
    Food Microbiol 29:49-55. 2012
    ..non-stressed, cold-stressed or freeze-stressed clinical STEC strains, including serogroups O26, O103, O111, O145, sorbitol fermenting (SF) O157 and non-sorbitol fermenting (NSF) O157...
  46. ncbi Purification and characterization of mannitol dehydrogenase and identification of the corresponding cDNA from the head blight fungus, Gibberella zeae (Fusarium graminearum)
    Frances Trail
    Department of Plant Biology, Michigan State University, East Lansing, MI 48824 1312, USA
    Phytochemistry 61:791-6. 2002
    ..0, and 7.0, respectively. Activity with sorbitol as the substrate was 21% of activity with mannitol...
  47. ncbi An alternative Candida spp. cell wall disruption method using a basic sorbitol lysis buffer and glass beads
    Crystale Siew Ying Lim
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia
    J Microbiol Methods 75:576-8. 2008
    ..which employs the use of glass beads in a simple sorbitol lysis buffer...
  48. ncbi Sugar levels modulate sorbitol dehydrogenase expression in maize
    Sylvia Morais de Sousa
    Centro de Biologia Molecular e Engenharia Genetica, Universidade Estadual de Campinas, Cidade Universitaria Zeferino Vaz, CP 6010, 13083 875 Campinas, SP, Brazil
    Plant Mol Biol 68:203-13. 2008
    ..This fructose can enter subsequent metabolism via hexokinase, or in maize kernels, by a sorbitol dehydrogenase that reversibly converts fructose + NADH to sorbitol + NAD...
  49. ncbi Glassy dynamics of sorbitol solutions at terahertz frequencies
    Juraj Sibik
    Department of Chemical Engineering and Biotechnology, University of Cambridge, New Museums Site, Pembroke Street, Cambridge, CB2 3RA, UK
    Phys Chem Chem Phys 15:11931-42. 2013
    The absorption spectra of D-sorbitol and a range of its concentrated aqueous solutions were studied by terahertz spectroscopy over the temperature interval of 80 K < T < 310 K...
  50. pmc Identification of the operon for the sorbitol (Glucitol) Phosphoenolpyruvate:Sugar phosphotransferase system in Streptococcus mutans
    D A Boyd
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W2
    Infect Immun 68:925-30. 2000
    ..5-kb contiguous region containing six open reading frames constituting the operon for the sorbitol P-enolpyruvate phosphotransferase transport system (PTS) of Streptococcus mutans LT11...
  51. ncbi Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice
    T F Ng
    Institute of Molecular Biology, The University of Hong Kong, China
    Diabetes 47:961-6. 1998
    In this report, we made use of sorbitol dehydrogenase (SDH)-deficient mutant mice (C57BL/LiA) to test whether there is a close correlation between the level of polyol accumulation and the degree of reduction in motor nerve conduction ..
  52. pmc Ileocolic perforation secondary to sodium polystyrene sulfonate in sorbitol use: a case report
    Vincent Trottier
    Department of General Surgery, Centre Hospitalier Affilie Universitaire De Quebec, Quebec City, Quebec
    Can J Gastroenterol 23:689-90. 2009
    ..It can lead to various complications including cardiac arrhythmias. Sodium polystyrene sulfonate (SPS) in sorbitol is an ion-exchange resin that can be used to treat hyperkalemia. It can be used in enema or in oral form...
  53. ncbi Interference of bovine herpesvirus 1 (BHV-1) in sorbitol-Induced apoptosis
    L De Martino
    Department of Pathology and Animal Health, School of Veterinary Medicine, University of Naples Federico II, 80137 Naples, Italy
    J Cell Biochem 89:373-80. 2003
    ..ability of bovine herpesvirus type 1 (BHV-1) to suppress apoptosis, we examined the effects of BHV-1 infection on sorbitol-induced apoptosis on Madin-Darby bovine kidney (MDBK) cells...
  54. ncbi Effects of trehalose and sorbitol on the activity and structure of Pseudomonas cepacia lipase: spectroscopic insight
    Azadeh Azizi
    Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
    Int J Biol Macromol 49:652-6. 2011
    ..In this study we have investigated the effects of sorbitol and trehalose on the structural stability and activity of Pseudomonas cepacia lipase (PCL), using UV-visible, ..
  55. ncbi Salivary mutans streptococci and dental caries in three-year-old children after maternal exposure to chewing gums containing combinations of xylitol, sorbitol, chlorhexidine, and fluoride
    Ingrid Thorild
    Public Dental Clinic, Varberg, Sweden
    Acta Odontol Scand 62:245-50. 2004
    ..aim of this study was to evaluate the effect of maternal use of chewing gums containing combinations of xylitol, sorbitol, chlorhexidine, and fluoride on salivary mutans streptococci (MS) counts and caries prevalence in the mothers' 3-..
  56. ncbi Successful treatment of a colonic ulcer penetrating the urinary bladder caused by the administration of calcium polystyrene sulfonate and sorbitol
    Takeshi Shioya
    Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Japan
    J Nippon Med Sch 74:359-63. 2007
    ..After admission, she received oral calcium polystyrene sulfonate and sorbitol to treat hyperkalemia. Nine days later, severe abdominal pain developed...
  57. ncbi Molecular properties of membrane-bound FAD-containing D-sorbitol dehydrogenase from thermotolerant Gluconobacter frateurii isolated from Thailand
    Hirohide Toyama
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Japan
    Biosci Biotechnol Biochem 69:1120-9. 2005
    There are two types of membrane-bound D-sorbitol dehydrogenase (SLDH) reported: PQQ-SLDH, having pyrroloquinoline quinone (PQQ), and FAD-SLDH, containing FAD and heme c as the prosthetic groups...
  58. pmc Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157: indications for an animal reservoir
    D Orth
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Laboratory for EHEC STEC VTEC, Innsbruck, Austria
    Epidemiol Infect 134:719-23. 2006
    This study investigates a sorbitol-fermenting enterohaemorrhagic Escherichia coli (SF EHEC) O157 infection in a farmer's family in the Austrian province of Salzburg...
  59. ncbi Parallel activation of Ca(2+)-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
    M Chiong
    Centro FONDAP Estudios Moleculares de la Celula, Universidad de Chile, Santiago, Chile
    Apoptosis 15:887-903. 2010
    ..Here, we investigated if Ca(2+) signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] elicited large and oscillatory intracellular Ca(2+) concentration increases...
  60. ncbi Attenuated total reflectance Fourier transform mid-infrared spectroscopic quantification of sorbitol and sorbose during a Gluconobacter biotransformation process
    Sue Macauley-Patrick
    Strathclyde Fermentation Centre, Department of Bioscience, University of Strathclyde, 204 George St, Glasgow G1 1XW, UK
    Biotechnol Lett 25:257-60. 2003
    Mid-infrared spectroscopy (MIRS) was used to simultaneously detect and predict concentrations of D-sorbitol and L-sorbose during a Gluconobacter suboxydans biotransformation...
  61. ncbi Transcranial doppler monitoring of intracranial pressure therapy with mannitol, sorbitol and glycerol in patients with acute stroke
    J Treib
    Department of Neurology, University of the Saarland, Homburg, Germany
    Eur Neurol 40:212-9. 1998
    ..Using transcranial Doppler (TCD), a continuous monitoring of ICP is now possible, because the TCD pulsatility index (PI) intraindividually closely correlates with the level of ICP...
  62. ncbi The biotechnological production of sorbitol
    M M Silveira
    Universidade de Caxias do Sul Instituto de Biotecnologia CP 1352, 95001 970 Caxias do Sul, RS, Brazil
    Appl Microbiol Biotechnol 59:400-8. 2002
    b>Sorbitol, a polyol found in many fruits, is of increasing industrial interest as a sweetener, humectant, texturizer and softener. At present, it is produced chemically...
  63. ncbi Influence of NaCl and sorbitol on the stability of conformations of cytochrome c
    J Bágel'ová
    Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, Kosice, Slovak Republic
    Biophys Chem 135:110-5. 2008
    Influence of ionic (NaCl) and non-ionic (sorbitol) additives on structural transitions of cytochrome c was investigated by circular dichroism, optical and EPR spectroscopy...
  64. ncbi Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes
    Y Sugiyama
    Basic Research Laboratory, Kanebo Ltd, 5-3-28 Kotobuki-cho, 250-0002, Odawara, Japan
    Biochim Biophys Acta 1522:82-8. 2001
    ..Incubation of keratinocytes in sorbitol-added hypertonic medium increased AQP3 mRNA expression...
  65. pmc Cattle can be a reservoir of sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H(-) strains and a source of human diseases
    M Bielaszewska
    Institute for Medical Microbiology, The 2nd Medical Faculty, Charles University, 150 06 Prague, Czech Republic
    J Clin Microbiol 38:3470-3. 2000
    Using the immunomagnetic separation procedure, we isolated sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157:H(-) strains from two patients, one with hemolytic-uremic syndrome and the other with diarrhea, and ..
  66. ncbi Sorbitol-induced apoptosis of human leukemia is mediated by caspase activation and cytochrome c release
    Gabriella Marfe
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Arch Toxicol 82:371-7. 2008
    It has been reported that sorbitol induces apoptosis in several cancer cell lines. However, the molecular mechanism underlying the sorbitol-induced apoptotic process is not yet clearly understood...
  67. ncbi Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance
    P Muthenna
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 604, India
    FEBS Lett 583:3637-42. 2009
    Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes...
  68. ncbi Noninvasive functional liver blood flow measurement: comparison between bolus dose and steady-state clearance of sorbitol in a small-rodent model
    Ben van der Hoven
    Department of Intensive Care, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 298:G177-81. 2010
    Plasma clearance of D-sorbitol, a nontoxic polyol, occurs predominantly in the liver and has been used to measure functional liver blood flow after bolus and steady- state intravenous administration...
  69. ncbi Physicochemical characterization of solid dispersions of indomethacin with PEG 6000, Myrj 52, lactose, sorbitol, dextrin, and Eudragit E100
    Hadi Valizadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    Drug Dev Ind Pharm 30:303-17. 2004
    ..polyethylene glycol (PEG) 6000, Myrj 52, Eudragit E100, and different carbohydrates such as lactose, mannitol, sorbitol, and dextrin. Indomethacin is a class II substance according to the Biopharmaceutics Classification System...
  70. ncbi Distinct physiological roles of two membrane-bound dehydrogenases responsible for D-sorbitol oxidation in Gluconobacter frateurii
    Wichai Soemphol
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Biosci Biotechnol Biochem 72:842-50. 2008
    Two different membrane-bound enzymes oxidizing D-sorbitol are found in Gluconobacter frateurii THD32: pyroloquinoline quinone-dependent glycerol dehydrogenase (PQQ-GLDH) and FAD-dependent D-sorbitol dehydrogenase (FAD-SLDH)...
  71. ncbi Lidocaine/monoethylglycinexylidide test, galactose elimination test, and sorbitol elimination test for metabolic assessment of liver cell bioreactors
    Jörg C Gerlach
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Artif Organs 34:462-72. 2010
    ..Measurements of monoethylglycinexylidide synthesis and elimination of lidocaine, galactose elimination, and sorbitol elimination proved to be useful for routine QA of primary liver cell cultures...
  72. ncbi Desperately seeking diarrhoea: outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009
    S Nielsen
    European Programme for Intervention Epidemiology Training EPIET, European Centre for Disease Prevention and Control ECDC, Stockholm, Sweden
    Zoonoses Public Health 58:567-72. 2011
    Infection with sorbitol-fermenting Shiga toxin-producing Escherichia coli O157:H- (sf STEC O157:H-) is rare, but emerging in Europe...
  73. ncbi Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules
    Jie Song
    Department of Medicinal amd Pharmaceutical Chemistry, University of Kiel, Gutenbergstrasse 76, 24118, Kiel, Germany
    Biochim Biophys Acta 1818:1218-24. 2012
    ..e. sucrose, sorbitol, PEG300, and glycerol...
  74. ncbi Association of prescription of oral sodium polystyrene sulfonate with sorbitol in an inpatient setting with colonic necrosis: a retrospective cohort study
    Maura A Watson
    Nephrology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA
    Am J Kidney Dis 60:409-16. 2012
    Colonic necrosis has been reported after sodium polystyrene sulfonate (SPS)/sorbitol use, but the incidence and relative risk (RR) are not established.
  75. ncbi Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance
    G Sundkvist
    Department of Endocrinology, University of Lund, Malmo University Hospital, Sweden
    Diabet Med 17:259-68. 2000
    b>Sorbitol and myo-inositol levels and morphology of sural nerve were compared with nerve function and clinical neuropathy in men with diabetic, impaired (IGT), and normal glucose tolerance.
  76. ncbi Fibre-optic biosensor based on luminescence and immobilized enzymes: microdetermination of sorbitol, ethanol and oxaloacetate
    S M Gautier
    Laboratoire de Génie Enzymatique Atelier de Biotechnologie, CNRS Université Claude Bernard Lyon, Villeurbanne, France
    J Biolumin Chemilumin 5:57-63. 1990
    ..Various NAD(P)-dependent enzymes, sorbitol dehydrogenase, alcohol dehydrogenase and malate dehydrogenase, were co-immobilized on preactivated polyamide ..
  77. ncbi Guanidine-containing molecular transporters: sorbitol-based transporters show high intracellular selectivity toward mitochondria
    Kaustabh K Maiti
    Department of Chemistry, Pohang University of Science and Technology, Pohang 790 784, Korea
    Angew Chem Int Ed Engl 46:5880-4. 2007
  78. ncbi Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state
    Liuquan Lucy Chang
    Department of Pharmaceutics, School of Pharmacy, University of Connecticut, Storrs, CN 06269, USA
    J Pharm Sci 94:1445-55. 2005
    ..To investigate the effect of plasticizers on the stability of protein formulations in the solid state and to apply these results to a study of mechanisms of protein stabilization by sugars in the solid sate...
  79. ncbi Colonic necrosis in a young patient receiving oral kayexalate in sorbitol: case report and literature review
    Yueh Hung Chou
    Department of Anatomical Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Kaohsiung J Med Sci 27:155-8. 2011
    ..Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal...
  80. pmc A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol
    Lucy Rutten
    Department of Crystal and Structural Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    BMC Microbiol 9:166. 2009
    ..only differ in the activity on their biological substrate, but also that only XDH has significant activity on D-sorbitol and may therefore be more closely related to D-sorbitol dehydrogenases (SDH)...
  81. pmc ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells
    Miguel A Lanaspa
    Department of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 284:19974-81. 2009
    ..Because ZAC1 has been described to be a potential negative regulator of sorbitol dehydrogenase (SDH) in hippocampal cells, we examined whether this relationship also occurs in kidney cells under ..
  82. ncbi Sorbitol accumulation and transmembrane efflux in osmotically stressed JS1 schwannoma cells
    A P Mizisin
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
    Neurosci Lett 229:53-6. 1997
    b>Sorbitol accumulation and transmembrane efflux in JS1 schwannoma cells were examined during osmotic stress in the presence of a sorbitol dehydrogenase (SD) inhibitor and following return to iso-osmotic conditions...
  83. pmc Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation
    Yasuo Ido
    Boston Medical Center, EBRC 820, Diabetes and Metabolism Unit, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Antioxid Redox Signal 12:39-51. 2010
    These experiments were undertaken to assess the importance of cytoplasmic (c) sorbitol oxidation versus mitochondrial (m) pyruvate oxidation in mediating neural and vascular dysfunction attributable to hyperglycemia in diabetic rats...
  84. ncbi Fructose- and sorbitol-reduced diet improves mood and gastrointestinal disturbances in fructose malabsorbers
    M Ledochowski
    Dept of Clinical Nutrition, Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Scand J Gastroenterol 35:1048-52. 2000
    ..It was therefore of interest whether a fructose-reduced diet could not only improve gastrointestinal complaints but also depressive signs seen in fructose malabsorbers...
  85. ncbi Molecular and phenotypic profiling of sorbitol-fermenting Escherichia coli O157:H- human isolates from Finland
    M Eklund
    Enteric Bacteria Laboratory, Department of Bacterial and Inflammatory Diseases, National Public Health Institute KTL, Helsinki, Finland
    Clin Microbiol Infect 12:634-41. 2006
    ..enterohaemorrhagic Escherichia coli (EHEC)-hlyA, katP, espP, etpD, sfpA and the flagellar fliC gene, in nine sorbitol-fermenting (SF), beta-glucuronidase-positive E...
  86. ncbi Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157 in Austria
    Dorothea Orth
    Austrian Reference Center for Enterohemorrhagic Escherichia coli, Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Wien Klin Wochenschr 121:108-12. 2009
    ..Shiga toxins are considered to be the most important virulence factor of EHEC strains. Non-sorbitol-fermenting EHEC O157:H7 is still the most prevalent serotype isolated worldwide; however, sorbitol-fermenting (SF)..
  87. ncbi A cerebroprotective dose of intravenous citrate/sorbitol-stabilized dehydroascorbic acid is correlated with increased cerebral ascorbic acid and inhibited lipid peroxidation after murine reperfused stroke
    William J Mack
    Department of Neurological Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:383-8; discussion 383-8. 2006
    ..We previously demonstrated that exogenously supplied dehydroascorbic acid (DHA), an oxidized, blood-brain barrier transportable form of the antioxidant ascorbic acid (AA), improves outcome after experimental stroke...
  88. ncbi Biosensor for the determination of sorbitol based on molecularly imprinted electrosynthesized polymers
    Liang Feng
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
    Biosens Bioelectron 19:1513-9. 2004
    ..biosensor based on molecularly imprinted electrosynthesized polymers is reported as the first case of imprinting sorbitol. A relevant molecularly imprinted film is prepared by o-phenylenediamine (o-PD) using the electrochemical method...
  89. ncbi Intragastric infusion of glucose enhances the rewarding effect of sorbitol fatty acid ester ingestion as measured by conditioned place preference in mice
    Shigenobu Matsumura
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Oiwakecho, Kitashirakawa, Sakyo ku, Kyoto City, 606 8502, Japan
    Physiol Behav 99:509-14. 2010
    ..Although mice showed high affinity for a low-energy fat substitute--sorbitol fatty acid esters and low-concentration linoleic acid solution--they did not exhibit a place preference toward a ..
  90. pmc Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase
    Wenlei Cao
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Biol Reprod 80:124-33. 2009
    ..Two major monosaccharides, sorbitol and fructose, are present in semen...
  91. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
    ..kg(-1) . day(-1)) for 6 weeks starting from induction of diabetes. Sorbitol pathway intermediate, but not glucose, accumulation in sciatic nerve and retina was completely prevented in ..
  92. ncbi Occurrence of non-sorbitol fermenting, verocytotoxin-lacking Escherichia coli O157 on cattle farms
    Katrijn Cobbaut
    Faculty of Veterinary Medicine, Department of Veterinary Public Health and Food Safety, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Microbiol 138:174-8. 2009
    ..8% (8/68) of the positive farms. From these eight farms, a total of 43 sorbitol-negative E. coli O157:H7 were collected...
  93. ncbi Effect of xylitol and sorbitol on plaque acidogenesis
    Christian H Splieth
    Department for Preventive and Pediatric Dentistry, Ernst Moritz Arndt University, Greifswald, Germany
    Quintessence Int 40:279-85. 2009
    To evaluate the in vivo potential of xylitol to reduce plaque acidogenicity in comparison to sorbitol.
  94. pmc Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway
    Slavena Vylkova
    Department of Oral Biology, SUNY at Buffalo Main Street Campus, Buffalo, NY 14214, USA
    Eukaryot Cell 6:1876-88. 2007
    ..C. albicans cells prestressed with sorbitol were less sensitive to subsequent Hst 5 treatment; however, cells treated concurrently with osmotic stress and ..
  95. pmc Presence and characterization of a mosaic genomic island which distinguishes sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H- from E. coli O157:H7
    Andreas Janka
    Institut fur Hygiene, Universitatsklinikum Munster, Robert Koch Strasse 41, D 48149 Munster, Germany
    Appl Environ Microbiol 71:4875-8. 2005
    ..flanked by segments of Escherichia coli O157:H7 strain EDL933 O islands 43, 81, and 82 was identified in sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H(-) strain 493/89...
  96. ncbi Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes
    Deepak Chandra
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA
    Diabetes 51:3095-101. 2002
    ..Herein we report that several nitric oxide (NO) donors prevent ex vivo synthesis of sorbitol in erythrocytes obtained from diabetic or nondiabetic rats...
  97. ncbi Another feature of TURP syndrome: hyperglycaemia and lactic acidosis caused by massive absorption of sorbitol
    C A Trépanier
    Department of Anesthesia, Centre Hospitalier Affilie Universitaire De Quebec, hôpital Enfant Jésus, Laval University, 1401, 18 Rue, Quebec, PQ, G1J 1Z4 Canada
    Br J Anaesth 87:316-9. 2001
    ..and lactic acidosis complicated the TURP syndrome caused by the massive absorption (approximately 15 litres) of a sorbitol- mannitol irrigation solution...
  98. pmc Ancestral divergence, genome diversification, and phylogeographic variation in subpopulations of sorbitol-negative, beta-glucuronidase-negative enterohemorrhagic Escherichia coli O157
    J Kim
    Department of Food Science and Technology, University of Nebraska, Lincoln, NE 68583 0919, USA
    J Bacteriol 183:6885-97. 2001
    ..including markers for acquisition of virulence genes and loss of physiological characteristics, such as sorbitol fermentation ability and beta-glucuronidase production...
  99. ncbi Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro
    Tasneem Zahir
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Mol Vis 12:1606-14. 2006
    The replacement of glucose by sorbitol in growth medium causes selection of astroglial cells from heterogeneous primary cultures derived from the brains of newborn mice...
  100. pmc Xylitol and D-arabitol toxicities due to derepressed fructose, galactitol, and sorbitol phosphotransferases of Escherichia coli
    A M Reiner
    J Bacteriol 132:166-73. 1977
    ..d-Arabitol sensitivity also occurs in sorbitol-constitutive strains and is shown, like the previous two instances of pentitol toxicities, to result from a ..
  101. ncbi Comparison of transcriptional responses to osmotic stresses induced by NaCl and sorbitol additions in Saccharomyces cerevisiae using DNA microarray
    Takashi Hirasawa
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biosci Bioeng 102:568-71. 2006
    ..laboratory and brewing strains of Saccharomyces cerevisiae to osmotic stresses induced by adding either NaCl or sorbitol to their cultures were compared by clustering DNA microarray data...

Research Grants62

  1. A novel role for endogenous fructose in ischemic acute kidney injury
    MIGUEL ANGEL LANASPA GARCIA; Fiscal Year: 2013
    ..The polyol pathway is a metabolic route constituted by two enzymes, aldose reductase and sorbitol dehydrogenase...
  2. The functions of the US3 protein kinase of herpes simplex virus
    Bernard Roizman; Fiscal Year: 2011
    ..g. sorbitol) was followed by the findings that (a) HSV encodes two isomers of US3 designated US3 and US3...
  3. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2012
    ..These parasite lines will be used phenotypic assays, such as sorbitol lysis and whole-cell patch clamp...
  4. Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial Drugs
    Michelle M Butler; Fiscal Year: 2013
    ..In preliminary studies, Dr. Sanjay Desai, NIH, developed and applied a screen for PSAC inhibitors using a sorbitol transport assay, that resulted in the identification of several chemotypes that displayed inhibitory potencies (..
  5. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..influence of the duration of the diabetic state on vagal and sciatic nerve concentrations of glucose, fructose, sorbitol, myoinositol, and Na+-K+-ATPase activity...
  6. Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo
    CHIFU HUANG; Fiscal Year: 2006
    ..g. phenylketonurics and diabetics). Moreover, altered sugar alcohol substitute sweeteners, i.e. sorbitol, xylitol, that have been marketed as noncariogenic sweeteners, and more recently as sweeteners for low ..
  7. MECHANISMS FOR INTESTINAL BILE ACID TRANSPORT
    Frederick Wilson; Fiscal Year: 1990
    ..The photolyzed cells are subjected to subcellular fractionation, using differential centrifugation and sorbitol gradient separation, followed by SDS-PAGE...
  8. FREEZING STORAGE OF HEART AT HIGH SUBZERO TEMPERATURES
    Tingchung Wang; Fiscal Year: 1993
    ..temperatures (-8 degrees C or higher) employing modest levels of natural cryoprotectants (glucose, glycerol, sorbitol, etc.)...
  9. RETINAL MICROVESSELS BASIS FOR INJURY IN DIABETES
    Gary Goldstein; Fiscal Year: 1990
    ..exposed to high concentrations of glucose in tissue culture, retinal pericytes and endothelial cell ssynthesize sorbitol. We believe that intracellular sorbitol may interfere with receptor mediated turnover of inositol phospholipids ..
  10. XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXIS
    Louis Vernacchio; Fiscal Year: 2003
    ..Phase II consists of a six-month pilot RCT of xylitol solution versus control (sorbitol) solution administered once daily or three times a day to children six to 24 months old for six months...
  11. ACE inhibitor and prevention of diabetic retinopathy
    Jinzhong Zhang; Fiscal Year: 2004
    ..b>Sorbitol, which can be produced within cells when intracellular glucose is elevated, likewise is increased in the retina ..
  12. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2004
    ..The accumulation of organic osmolytes (sorbitol, myo-inositol, taurine) normally protects the lens against osmotic imbalance by maintaining intracellular osmotic ..
  13. Physiology of Osmotic Stress in Saccharmyces cerevisiae
    Robert Ramirez; Fiscal Year: 2010
    ..For example, mammalian renal cells are known to accumulate glycerophosphocholine (GPC), glycine betaine, sorbitol, inositol and urea during anti-diuresis...
  14. Carbon Antioxidants to Prevent Diabetic Complications
    MICHAEL DIENER; Fiscal Year: 2007
    ..g., eliminates the increases in advanced glycation end-products, protein kinase C activity, sorbitol concentration, and hexosamine pathway flux...
  15. REGULATION OF RAT RENAL INNER MEDULLARY FUNCTION
    JEFF SANDS; Fiscal Year: 1993
    ..III-Inner medullary cells osmoregulate, in part, by regulating the production of intracellular sorbitol. Sorbitol production is regulated by the enzyme aldose reductase...
  16. SUGAR CATARACTS AND RETINOPATHY
    David Harrison; Fiscal Year: 2000
    ..There is a body of evidence that both the retinopathy and the cataracts found in diabetic patients are caused by sorbitol from the aldose reductase(AR)-catalyzed reduction of glucose...
  17. Role of fibrate mechanism in diabetes and its complications
    GANESARATNAM BALENDIRAN; Fiscal Year: 2010
    ..Our findings suggest that these drugs are better inhibitors for an enzyme that converts excess glucose to sorbitol under diabetic condition and plan to study their mechanism in diabetes and its complications.
  18. DIABETIC RETINOPATHY: BASIC STUDY IN PERICYTE METABOLISM
    Weiye Li; Fiscal Year: 1993
    ..In this application we propose to study the biochemical mechanisms by which this occurs. Activated sorbitol pathway and decreased myo-inositol content induced by high glucose may alter cell signal transduction through ..
  19. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..Mice are relatively deficient in aldose reductase (AR), the enzyme that converts glucose to sorbitol. We discovered that LDL receptor knockout mice (Ldlr-/-) made diabetic with streptozotocin (STZ) treatment have ..
  20. DIABETES AND BLADDER SMOOTH MUSCLE METABOLIC DYSFUNCTION
    CHRISTOPHER HARDIN; Fiscal Year: 2002
    ..However, in microvascular smooth muscle, pathological flux through the sorbitol pathway is a primary defect...
  21. PATHOGENESIS OF DIABETIC NEUROPATHY
    David Fink; Fiscal Year: 1993
    ..The link between reduced retrograde transport and the known metabolic abnormalities of hyperglycemia, nerve sorbitol accumulation, or nerve myoinositol depletion is not known...
  22. PHOSPHOLIPID METABOLISM IN DIABETIC NEUROPATHY
    Joseph Eichberg; Fiscal Year: 2001
    ..as well as in primary neonatal rat and human fetal Schwann cells by examining the effects of aldose reductase and sorbitol dehydrogenase inhibitors as well as Vit E and N-acetylcysteine, on arachidonyl containing molecular species (ACMS)..
  23. STRUCTURE-BASED ALDOSE REDUCTASE INHIBITORS
    DAVID BORHANI; Fiscal Year: 1992
    ..Aldose reductase catalyzes the reduction of glucose to sorbitol. It has been implicated in the pathogenesis of the chronic complications of diabetes mellitus...
  24. Lacrimal acinar secretory vesicle biogenesis and release
    Ronald Marchelletta; Fiscal Year: 2006
    ..isolation of subcellular membrane compartments from CCH-stimulated lacrimal acinar cells by centrifugation over sorbitol density gradients and partitioning into aqueous polyethyleneglycol-dextran followed by SDS-PAGE and Western ..
  25. DIABETES MELLITUS AND THE ANTERIOR SEGMENT OF THE EYE
    Richard Schultz; Fiscal Year: 1980
    ..membrane abnormalities seen with electron microscopy, unusual HLA antigen loci, and the identification of sorbitol and other carbohydrates in the corneal epithelium...
  26. GENETICS OF NEPHROPATHY IN HUMAN TYPE 2 DIABETES
    STEVEN ELBEIN; Fiscal Year: 2002
    ..b>Sorbitol accumulation and aldose reductase expression will be examined and tested for linkage to the aldose reductase ..
  27. PATHWAYS OF ETHANOL METABOLISM
    Bernard Landau; Fiscal Year: 1980
    ..will be estimated from the fate of the R hydrogen of ethanol compared to the hydrogen bound to carbon 2 of sorbitol. Whether (2-2H) sorbitol can be used in place of (2-3H) sorbitol will be determined...
  28. DEAZA ANALOGS OF ALDOSE REDUCTASE INHIBITORS
    ISAAC DONKOR; Fiscal Year: 1992
    ..Since aldose reductase catalyzes the conversion of excess glucose to sorbitol, inhibition of this enzyme represents a clinically useful approach toward the treatment and/or prevention of ..
  29. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..arterioles, metabolic indices such as nerve cytosolic and mitochondrial NAD+/NADH redox state, energy state, sorbitol pathway intermediates, and measures of oxidative stress such as nitrotyrosine, poly(ADPribose), lipid ..
  30. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..mice and the wild-type mice with normal PARP content; and 3) to identify contribution of two enzymes of the sorbitol pathway, aldose reductase and sorbitol dehydrogenase, and individual reactive oxygen species to high glucose-..
  31. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..without inhibiting the experimentally established initiators of diabetic cataract formation -- hyperglycemia and sorbitol formation, this proposal seeks to incorporate functional groups into 1-N,N'-dimethylsulfamoyl-4-(2-pyrimidyl)..
  32. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  33. Role of Organic Osmolytes in Renal Papillary Necrosis
    Gilbert Moeckel; Fiscal Year: 2007
    ..It is necessary to understand these processes in order to design effective diagnostic procedures, therapeutic approaches and preventive measures for RPN. ..
  34. Fluoride Varnish to Prevent Caries in Toddlers - An Expanded Immunization Program
    Peter Milgrom; Fiscal Year: 2008
    ..Keywords: fluoride varnish, dental caries, oral health, early prevention, multi-center, toddlers. [unreadable] [unreadable] [unreadable]..
  35. Role of COX2 in Medullary Interstitial Cell Survival and Function
    Gilbert Moeckel; Fiscal Year: 2008
    ..It is necessary to understand how these cells function in order to design better drugs to treat high blood pressure. [unreadable] [unreadable]..
  36. Biotech & Materials Research to Reduce Caries Disparity
    Peter Milgrom; Fiscal Year: 2005
    ..The conference will be co-sponsored by the Northwest/Alaska Center to Reduce Oral Health Disparities, the University of Washington UWeb Bioengineering Center, and the Salivary Diagnostics Project. ..
  37. Protein Biomarker Profiles of Abusive Alcohol Consumption
    Frank Witzmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  40. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..Thus, we are poised to understand the pathogenesis and develop novel therapies for diabetic autonomic neuropathy. ..
  41. DYSREGULATION OF THE TAURINE TRANSPORTER IN DIABETES
    Martin Stevens; Fiscal Year: 2002
    ..AR catalyzes the conversion of glucose to sorbitol and is thought to act as an osmotic stress response protein by compensating for hypertonic stress through ..
  42. Activated Sugars for Drug Discovery
    Ryan Woodyer; Fiscal Year: 2006
    ..These sugars can be used to make derivatives of natural products with new therapeutic properties, for example, antibiotics that are effective against antibiotic-resistant bacteria. [unreadable] [unreadable] [unreadable]..
  43. Development of QLF Handpiece for Early Caries Detection
    George Stookey; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  45. Optically enhanced dental sealants to indicate placement and material condition
    George Stookey; Fiscal Year: 2006
    ..unreadable] 3) An optically doped sealant combines the efficacy advantages of a clear sealant with the visibility advantages of an opaque sealant. [unreadable] [unreadable]..
  46. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  47. POLYOL PATHWAY AND ISCHEMIC INJURY IN DIABETIC HEARTS
    Ravichandran Ramasamy; Fiscal Year: 2005
    ..In polyol pathway, glucose is reduced to sorbitol by aldose reductase (AR) and subsequently oxidized to fructose by sorbitol dehydrogenase (SDH)...
  48. Caries Risk Assessment Instrument for Young Adults
    George Stookey; Fiscal Year: 2005
    ..Future large-scale investigations will be undertaken to validate the merits of the instrument. ..
  49. Clinical Models Workshop:Remin-Demin, Precavity, Caries
    George Stookey; Fiscal Year: 2005
    ..The meeting will be held on July 3-5, 2005 in the Downtown Marriott Hotel in Indianapolis, Indiana, immediately prior to the annual ORCA (European Organization for Caries Research) meeting. ..
  50. IN VIVO IMAGING OF GROWTH PLATE DYNAMICS
    Cornelia Farnum; Fiscal Year: 2009
    ..Detailed functional knowledge of vascular routes to the growth plate, and movement of molecules within the growth plate, is essential as thought is given to targeting therapeutic agents to the growth plate. ..
  51. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Mara Lorenzi; Fiscal Year: 2002
    ..If a chain of causal relationships is established, the studies will bring to the fore targets for rational interventions. ..
  53. Macromolecular X-Ray Crystallography Instrument
    Neela Yennawar; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  55. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
  56. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 2006
    ....
  57. Mood Disorders & Diabetes: Common Disease Mechanisms
    WILLIAM REGENOLD; Fiscal Year: 2005
    ..aims to determine whether increased conversion of glucose by aldose reductase through the polyol pathway to sorbitol--a potentially neurotoxic metabolite--is a mechanism of the brain white matter disease that has been associated ..