inositol

Summary

Summary: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.

Top Publications

  1. doi Myo-inositol and beyond--emerging networks under stress
    Ravi Valluru
    Ecophysiology of Plants Under Environmental Stress, INRA SUPAGRO, Institute of Integrative Plant Biology, 2 place Viala, Montpellier, France
    Plant Sci 181:387-400. 2011
  2. ncbi Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704)
    Deepak Singh
    Department of Biological Science, Institute of Bioscience and Biotechnology, Myongji University, Yongin, 449 728, Republic of Korea
    Gene 376:13-23. 2006
  3. pmc Two major inositol transporters and their role in cryptococcal virulence
    Yina Wang
    Public Health Research Institute, University of Medicine and Dentistry of New Jersey, ICPH Building, Room W250H, 225 Warren Street, Newark, NJ 07103, USA
    Eukaryot Cell 10:618-28. 2011
  4. pmc In Silico identification of pathogenic strains of Cronobacter from Biochemical data reveals association of inositol fermentation with pathogenicity
    Stephen E Hamby
    School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK
    BMC Microbiol 11:204. 2011
  5. ncbi Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, M5S 3H2, Canada
    J Biol Chem 275:18495-502. 2000
  6. ncbi Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Nat Med 9:1513-9. 2003
  7. ncbi Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism
    Amy B Manning-Bog
    The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085, USA
    Neurotoxicology 30:1127-32. 2009
  8. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
  9. pmc D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis
    Yu Luo
    State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, People s Republic of China
    Plant Cell 23:1352-72. 2011
  10. ncbi Inositol induces a profound alteration in the pattern and rate of synthesis and turnover of membrane lipids in Saccharomyces cerevisiae
    Maria L Gaspar
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, NY 14853, USA
    J Biol Chem 281:22773-85. 2006

Detail Information

Publications257 found, 100 shown here

  1. doi Myo-inositol and beyond--emerging networks under stress
    Ravi Valluru
    Ecophysiology of Plants Under Environmental Stress, INRA SUPAGRO, Institute of Integrative Plant Biology, 2 place Viala, Montpellier, France
    Plant Sci 181:387-400. 2011
    Myo-inositol is a versatile compound that generates diversified derivatives upon phosphorylation by lipid-dependent and -independent pathways...
  2. ncbi Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704)
    Deepak Singh
    Department of Biological Science, Institute of Bioscience and Biotechnology, Myongji University, Yongin, 449 728, Republic of Korea
    Gene 376:13-23. 2006
    ..This promises excellent opportunities to elucidate biosynthetic route(s) to the validamycin complex and to engineer the pathway for industrial application...
  3. pmc Two major inositol transporters and their role in cryptococcal virulence
    Yina Wang
    Public Health Research Institute, University of Medicine and Dentistry of New Jersey, ICPH Building, Room W250H, 225 Warren Street, Newark, NJ 07103, USA
    Eukaryot Cell 10:618-28. 2011
    ..The existence of high inositol concentrations in brain and our earlier discovery of a large inositol transporter (ITR) gene family in C...
  4. pmc In Silico identification of pathogenic strains of Cronobacter from Biochemical data reveals association of inositol fermentation with pathogenicity
    Stephen E Hamby
    School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK
    BMC Microbiol 11:204. 2011
    ..Therefore to be able to differentiate between the pathogenic and non-pathogenic strains is of interest to the food industry and regulators...
  5. ncbi Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, M5S 3H2, Canada
    J Biol Chem 275:18495-502. 2000
    b>Inositol has 8 stereoisomers, four of which are physiologically active. myo-Inositol is the most abundant isomer in the brain and more recently shown that epi- and scyllo-inositol are also present...
  6. ncbi Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Nat Med 9:1513-9. 2003
    ..Spina bifida in ct/ct mice is folate resistant, but its incidence can be markedly reduced by maternal inositol supplementation periconceptually...
  7. ncbi Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism
    Amy B Manning-Bog
    The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085, USA
    Neurotoxicology 30:1127-32. 2009
    ....
  8. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
    The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular activities...
  9. pmc D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis
    Yu Luo
    State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, People s Republic of China
    Plant Cell 23:1352-72. 2011
    In animal cells, myo-inositol is an important regulatory molecule in several physiological and biochemical processes, including signal transduction and membrane biogenesis...
  10. ncbi Inositol induces a profound alteration in the pattern and rate of synthesis and turnover of membrane lipids in Saccharomyces cerevisiae
    Maria L Gaspar
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, NY 14853, USA
    J Biol Chem 281:22773-85. 2006
    The addition of inositol to actively growing yeast cultures causes a rapid increase in the rate of synthesis of phosphatidylinositol and, simultaneously, triggers changes in the expression of hundreds of genes...
  11. ncbi IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity
    Kim Cryns
    Research and Early Development Europe, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Neuropsychopharmacology 33:674-84. 2008
    ..Intriguingly, the embryonic lethality could be reversed by myo-inositol supplementation via the pregnant mothers...
  12. pmc Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    J Affect Disord 119:186-9. 2009
    ..Frontal Glx levels appear to be normalised after recovery from depression, but it is not known if this composite measure masks ongoing differences in glutamate or glutamine alone...
  13. doi 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders
    Lidia Gabis
    Weinberg Child Development Center, Safra Children s Hospital, Tel Hashomer, Israel
    J Child Neurol 23:766-74. 2008
    ..lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions...
  14. pmc In vivo mapping of brain myo-inositol
    Mohammad Haris
    Center for Magnetic Resonance and Optical Imaging CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6100, USA
    Neuroimage 54:2079-85. 2011
    Myo-Inositol (MI) is one of the most abundant metabolites in the human brain located mainly in glial cells and functions as an osmolyte...
  15. pmc Down-regulation of the myo-inositol oxygenase gene family has no effect on cell wall composition in Arabidopsis
    Stefanie Endres
    Department of Cell Biology, Plant Physiology, University of Salzburg, Hellbrunnerstr 34, 5020 Salzburg, Austria
    Planta 234:157-69. 2011
    The enzyme myo-inositol oxygenase (MIOX; E.C. 1.13.99...
  16. pmc The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium
    Pishan Chang
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK
    Dis Model Mech 5:115-24. 2012
    ..and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis...
  17. pmc Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis
    Shumpei Asamizu
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Am Chem Soc 133:12124-35. 2011
    ..The enzyme operates in sequence with a phosphatase, which dephosphorylates validoxylamine A 7'-phosphate to validoxylamine A...
  18. pmc Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
    Thanyarat Promlek
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Biol Cell 22:3520-32. 2011
    ..In contrast, this mutant was activated like wild-type Ire1 by depletion of the membrane lipid component inositol or by deletion of genes involved in lipid homeostasis...
  19. doi Structure-function studies for the panacea, valproic acid
    Nicole Terbach
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK
    Biochem Soc Trans 37:1126-32. 2009
    ..This short review will describe potential therapeutic pathways targeted by VPA, and highlight studies showing structural constraints necessary for these effects...
  20. ncbi Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae
    Andrew M Seeds
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27654-61. 2005
    The production of inositol polyphosphate (IPs) and pyrophosphates (PP-IPs) from inositol 1,4,5-trisphosphate (I(1,4,5)P3) requires the 6-/3-/5-kinase activity of Ipk2 (also known as Arg82 and inositol polyphosphate multikinase)...
  21. pmc Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice
    Shuang Qing Chen
    Department of Radiology, Tongji Hospital, Tongji University, Shanghai, China
    Dement Geriatr Cogn Disord 28:558-66. 2009
    To explore the potential value of myo-inositol (mIns), which is regarded as a biomarker for early diagnosis of Alzheimer's disease, in APP/PS1 transgenic (tg) mice detected by (1)H-MRS.
  22. pmc Regulation of phospholipid synthesis in yeast
    George M Carman
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 50:S69-73. 2009
    ..Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression...
  23. pmc Myoinositol oxygenase controls the level of myoinositol in Arabidopsis, but does not increase ascorbic acid
    Stefanie Endres
    University of Salzburg, 5020 Salzburg, Austria
    Plant Physiol 149:1042-9. 2009
    ..We conclude that D-GlcUA derived from the Miox reaction plays a negligible role for AsA biosynthesis. However, Miox controls the metabolite level of myoinositol in plants...
  24. doi Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial
    Enrico Papaleo
    IVF Unit, Gynecologic Obstetric Department, Istituto di Ricovera e Cura a Carattere Scientifico, San Raffaele Hospital, Vita Salute University, Milan, Italy
    Fertil Steril 91:1750-4. 2009
    To determine the effects of myo-inositol on oocyte quality in polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI) cycles.
  25. ncbi Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis
    K T M Fernando
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 127:1361-9. 2004
    ..total creatine and phosphocreatine (Cr), choline-containing compounds, glutamate plus glutamine, and myo-inositol (Ins) were estimated automatically using the LCModel...
  26. ncbi The biosynthesis of acarbose and validamycin
    T Mahmud
    Department of Chemistry, University of Washington, Seattle, 98195-1700, USA
    Chem Rec 1:300-10. 2001
    ..The stage is now set for unraveling the mechanism or mechanisms by which the two components of the pseudodisaccharide moieties of acarbose and validamycin are uniquely coupled to each other via a nitrogen bridge...
  27. doi A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity
    Dario Panzeri
    Istituto di Biologia e Biotecnologia Agraria, CNR, Milano, Italy
    New Phytol 191:70-83. 2011
    ..expression level of several genes of the InsP(6) pathway are reduced in the lpa1(280-10) mutant as well as the inositol and raffinosaccharide content. PvMrp2, a very similar paralogue of PvMrp1 was also mapped and sequenced...
  28. pmc Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla
    Lana G Kaiser
    Department of Radiology, University of California San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA
    NMR Biomed 18:51-5. 2005
    The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T...
  29. doi Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging
    Finian M O'Brien
    Department of Psychological Medicine, Kings College London, UK
    Psychiatry Res 184:77-85. 2010
    ..1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)...
  30. pmc Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol
    D W Heinz
    Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
    EMBO J 14:3855-63. 1995
    ..site of the enzyme has been identified by determining the structure of PI-PLC in complex with its inhibitor, myo-inositol, at 2.6 A resolution (R factor = 19.5%)...
  31. pmc Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins
    D Hamburger
    Biozentrum of the University of Basel, Switzerland
    J Cell Biol 129:629-39. 1995
    ..Therefore, Gaa1p is required for a terminal step of GPI anchor attachment and could be part of the putative GPI:protein transamidase...
  32. ncbi How do inositol and glucose modulate feeding in Manduca sexta caterpillars?
    J I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
    J Exp Biol 203:1299-315. 2000
    Many species of caterpillar possess taste cells that respond exceptionally vigorously to the sugar alcohol myo-inositol. We examined the functional significance of these inositol-sensitive taste cells in Manduca sexta caterpillars through ..
  33. pmc ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A
    Kazuyuki Minagawa
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331 3507, USA
    Chembiochem 8:632-41. 2007
    ..The results provide new insights into the activity of this enzyme and also confirm the existence of two different pathways leading to the same end-product: the valienamine moiety common to acarbose and validamycin A...
  34. ncbi Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway
    Chang Sheng Zhang
    Institute of Chemical Microbiology Bergische University, Gauss Strasse 20, D 42097 Wuppertal, Germany
    J Biol Chem 277:22853-62. 2002
    ..A biosynthetic pathway for the pseudodisaccharidic acarviosyl moiety of acarbose is proposed on the basis of these data...
  35. ncbi Untreated glioblastoma multiforme: increased myo-inositol and glutamine levels in the contralateral cerebral hemisphere at proton MR spectroscopy
    Kai Kallenberg
    MR Research in Neurology and Psychiatry, Department of Neuroradiology, Universitymedicine, Georg August Universitat Gottingen, Robert Koch Strasse 40, 37099 Gottingen, Germany
    Radiology 253:805-12. 2009
    ....
  36. pmc Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    J Autism Dev Disord 39:1079-86. 2009
    ..This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD...
  37. pmc Alternative epimerization in C(7)N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of the vicinal oxygen chelate superfamily
    Hui Xu
    Shanghai Jiao Tong University, China
    Chem Biol 16:567-76. 2009
    ..Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis...
  38. pmc Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008
    Yi Yu
    Bio X Life Science Research Center, Shanghai Jiaotong University, Shanghai 200030, China
    Appl Environ Microbiol 71:5066-76. 2005
    ..coli. The information obtained should pave the way for further detailed analysis of the complete biosynthetic pathway, which would lead to a complete understanding of validamycin biosynthesis...
  39. pmc Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis
    C Sutterlin
    Biozentrum of the University of Basel, Switzerland
    EMBO J 16:6374-83. 1997
    ..Consistent with the block in GPI synthesis, YW3548 prevents the incorporation of [3H]myo-inositol into proteins, transport of GPI-anchored proteins to the Golgi and is toxic...
  40. doi The cellular language of myo-inositol signaling
    Glenda E Gillaspy
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    New Phytol 192:823-39. 2011
    The simple polyol, myo-inositol, is used as a building block of a cellular language that plays various roles in signal transduction...
  41. pmc Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling
    Manuel J Villa-García
    Department of Molecular Biology and Genetics, Cornell University, 249 Biotechnology Building, Ithaca, NY 14853, USA
    Mol Genet Genomics 285:125-49. 2011
    b>Inositol auxotrophy (Ino(-) phenotype) in budding yeast has classically been associated with misregulation of INO1 and other genes involved in lipid metabolism...
  42. ncbi A novel salt-tolerant L-myo-inositol-1-phosphate synthase from Porteresia coarctata (Roxb.) Tateoka, a halophytic wild rice: molecular cloning, bacterial overexpression, characterization, and functional introgression into tobacco-conferring salt tolerance
    Manoj Majee
    Plant Molecular and Cellular Genetics, Bose Institute Centenary Building, P 1 12, CIT Scheme VII M, Kolkata 700054, India
    J Biol Chem 279:28539-52. 2004
    l-myo-Inositol-1-phosphate synthase (EC 5.5.1.4, MIPS), an evolutionarily conserved enzyme protein, catalyzes the synthesis of inositol, which is implicated in a number of metabolic reactions in the biological kingdom...
  43. ncbi High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression
    Huirong Zheng
    Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
    Prog Neuropsychopharmacol Biol Psychiatry 34:1189-95. 2010
    ..In this study metabolic changes within PFC of severely depressed patients before and after rTMS were evaluated by proton magnetic resonance spectroscopy (1H-MRS)...
  44. ncbi The C7N aminocyclitol family of natural products
    Taifo Mahmud
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Nat Prod Rep 20:137-66. 2003
    ..The literature from 1970 to July 2002 is reviewed, with 269 references cited...
  45. pmc Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A
    Linquan Bai
    Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030, China
    Chem Biol 13:387-97. 2006
    ..The role of valG in the glycosylation of validoxylamine to VAL-A was demonstrated in vitro by enzymatic assay...
  46. doi Enhanced salt tolerance of transgenic tobacco plants by co-expression of PcINO1 and McIMT1 is accompanied by increased level of myo-inositol and methylated inositol
    Barunava Patra
    Plant Molecular and Cellular Genetics, Bose Institute Centenary Building, P1 12, C I T Scheme VIIM, Kolkata, 700054, India
    Protoplasma 245:143-52. 2010
    Introgression and functional expression of either the PcINO1 (L: -myo-inositol 1-phosphate synthase or MIPS coding gene from the wild halophytic rice, Porteresia coarctata) or McIMTI (inositol methyl transferase, IMTI coding gene from ..
  47. ncbi Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
    Stephen K Fisher
    Mental Health Research Institute, and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurochem 82:736-54. 2002
    b>Inositol phospholipids and inositol phosphates mediate well-established functions in signal transduction and in Ca2+ homeostasis in the CNS and non-neural tissues...
  48. pmc Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis
    Lina Zheng
    Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 7:e32033. 2012
    ..Furthermore, the modeling of V7P in the active site of ValL suggests that ValL might have a similar SNi-like mechanism as OtsA...
  49. doi Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p
    Niketa M Jani
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mol Microbiol 70:1529-39. 2008
    ..g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence...
  50. pmc Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it
    Todd B Reynolds
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Microbiology 155:1386-96. 2009
    myo-Inositol (inositol) is an essential nutrient that is used for building phosphatidylinositol and its derivatives in eukaryotes and even in some eubacteria such as the mycobacteria...
  51. ncbi Gray and white matter brain chemistry in young children with autism
    Seth D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
    Arch Gen Psychiatry 63:786-94. 2006
    ..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
  52. doi Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice
    Kristin McLarty
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 38:953-9. 2011
    The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice...
  53. pmc Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve
    Lawrence J Coppey
    Veterans Affairs Medical Center, Department of Internal Medicine, University of Iowa, Iowa City 52246, USA
    Int J Exp Diabetes Res 3:21-36. 2002
    ..Treatment of diabetic rats with aldose reductase inhibitors, aminoguanidine or myo-inositol supplementation have been shown to improve motor nerve conduction velocity and/or decreased endoneurial blood ..
  54. pmc Determination of transport stoichiometry for two cation-coupled myo-inositol cotransporters: SMIT2 and HMIT
    Francis Bourgeois
    Groupe d étude des protéines membranaires GÉPROM, Universite de Montreal, CP 6128, Succ Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Physiol 563:333-43. 2005
    Three different mammalian myo-inositol cotransporters are currently known; two are Na+-coupled (SMIT1 and SMIT2) and one is proton-coupled (HMIT)...
  55. doi D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-Ay mice
    Yang Yao
    Institute of Crop Science, Chinese Academy of Agricultural Sciences, No 80 South Xueyuan Road, Haidian District, Beijing, People s Republic of China 100081
    J Agric Food Chem 56:10027-31. 2008
    D-chiro-inositol (DCI) is an active compound in tartary buckwheat [Fagopyrum tataricum (L.) Gaench] with an insulin-like bioactivity...
  56. pmc The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death
    Janet L Donahue
    Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
    Plant Cell 22:888-903. 2010
    l-myo-inositol 1-phosphate synthase (MIPS; EC 5.5.1.4) catalyzes the rate-limiting step in the synthesis of myo-inositol, a critical compound in the cell. Plants contain multiple MIPS genes, which encode highly similar enzymes...
  57. pmc Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis
    Farahnaz Movahedzadeh
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    BMC Microbiol 10:50. 2010
    Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan (LAM), lipomannan (LM) and phosphatidylinosotol mannosides (PIMs) in the cell envelope, and for the production of mycothiol, which maintains the redox ..
  58. pmc Crosstalks between myo-inositol metabolism, programmed cell death and basal immunity in Arabidopsis
    Ping Hong Meng
    Institut de Biotechnologie des Plantes, UMR CNRS 8618, Universite Paris Sud XI, Bat 630, Plateau de Moulon, Orsay, France
    PLoS ONE 4:e7364. 2009
    ..yeast two-hybrid screen using ATXR5 as bait captured AtIPS1, an enzyme which catalyses the committed step of myo-inositol (MI) biosynthesis...
  59. doi Small molecule beta-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease
    Cheryl A Hawkes
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 31:203-13. 2010
    ..We have previously reported that scyllo-inositol inhibits Abeta(42) fibril formation but the mechanism(s) by which this occurs has not been investigated in detail...
  60. pmc Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes
    Jason King
    School of Biosciences, Cardiff University, Cardiff, UK
    PLoS ONE 5:e11151. 2010
    ..Further studies demonstrated that PO is a negative regulator of inositol(1,4,5)trisphosphate (IP(3)) synthesis, a Li(+) sensitive intracellular signal...
  61. ncbi Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
    S S Hecht
    University of Minnesota Cancer Center, Minneapolis 55455, USA
    Cancer Lett 137:123-30. 1999
    The potential activities of butylated hydroxyanisole (BHA), myo-inositol, curcumin, esculetin, resveratrol and lycopene-enriched tomato oleoresin (LTO) as chemopreventive agents against lung tumor induction in A/J mice by the tobacco ..
  62. pmc Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells
    Xiaobo Lin
    Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue Box 8127, St Louis, MO 63110, USA
    Arch Biochem Biophys 481:197-201. 2009
    To characterize the function of the sodium/inositol symporter SMIT2 in skeletal muscle, human SMIT2 cDNA was transfected into L6 myoblasts using pcDNA3.1 expression vector. Compared with the pcDNA3...
  63. pmc Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction
    Paul L Wood
    Phenomenome Discoveries Inc, 204 407 Downey Road, Saskatoon, SK S7N4L8, Canada
    Lipids Health Dis 10:102. 2011
    ..Further targeted metabolomics analyses were conducted to obtain a preliminary evaluation of the metabolic consequences of lipid changes and gene mutations in these cell models...
  64. ncbi Measurement of brain glutamate using TE-averaged PRESS at 3T
    Ralph Hurd
    GE Medical Systems, Menlo Park, California, USA
    Magn Reson Med 51:435-40. 2004
    ..A repeatibility error of <5%, and a coefficient of variation (CV) of <10% were observed for brain Glu levels in a study of six normal volunteers...
  65. ncbi Inositol prevents folate-resistant neural tube defects in the mouse
    N D Greene
    Neural Development Unit, Institute of Child Health, University of London, UK
    Nat Med 3:60-6. 1997
    ..Here, we show that a second vitamin, myo-inositol, is capable of significantly reducing the incidence of spinal NTDs in curly tail mice, a genetic model of folate-..
  66. ncbi Small molecule enhancers of autophagy for neurodegenerative diseases
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Mol Biosyst 4:895-901. 2008
    ..We will discuss various autophagy-inducing small molecules that have emerged in the past few years that may be leads towards the treatment of such devastating diseases...
  67. ncbi IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae
    J Nikawa
    Department of Biochemistry, Gunma University School of Medicine, Maebashi, Japan
    Mol Microbiol 6:1441-6. 1992
    ..Disruption of the IRE1 locus caused myo-inositol auxotrophy. The IRE1 product is very likely a protein kinase required for myo-inositol synthesis.
  68. ncbi Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex
    Philip E Brandish
    Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    Neuron 45:861-72. 2005
    Lithium inhibits inositol monophosphatase at therapeutically effective concentrations, and it has been hypothesized that depletion of brain inositol levels is an important chemical alteration for lithium's therapeutic efficacy in bipolar ..
  69. pmc Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection
    Ying Lien Chen
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Infect Immun 76:2793-801. 2008
    ..In order to cause infections, C. albicans must be able to synthesize the essential metabolite inositol or acquire it from the host. Based on the similarity of C...
  70. ncbi Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae
    J Nikawa
    Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka
    J Biochem 118:39-45. 1995
    Saccharomyces cerevisiae ire15 mutant has a defect in the expression of INO1, showing the inositol auxotrophic phenotype [Nikawa, J. (1994) Gene 149, 367-372]...
  71. ncbi Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
    Radhika Srinivasan
    Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
    Brain 128:1016-25. 2005
    ..Metabolite concentrations (glutamate, glutamine, N-acetyl-aspartate, myo-inositol, choline, creatine) were derived from LCmodel and corrected for T1 relaxation time...
  72. doi Myoinositol content in the human brain is modified by transcranial direct current stimulation in a matter of minutes: a 1H-MRS study
    M Rango
    Department of Neurological Sciences, University of Milan, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
    Magn Reson Med 60:782-9. 2008
    ..1)H-MRS represents a powerful tool to follow the regional effects of tDCS on brain mI and, possibly, on the related phosphoinositide system...
  73. doi Knockout mice in understanding the mechanism of action of lithium
    Galila Agam
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochem Soc Trans 37:1121-5. 2009
    Lithium inhibits IMPase (inositol monophosphatase) activity, as well as inositol transporter function...
  74. doi InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins
    Mahesh Kulharia
    Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK
    J Mol Graph Model 28:297-303. 2009
    ..In this paper we present a new method called InCa-SiteFinder for predicting non-covalent inositol and carbohydrate binding sites on the surface of protein structures...
  75. pmc Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis
    Catherine Vilcheze
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Microbiol 69:1316-29. 2008
    ..Mutations in mshA demonstrate the non-essentiality of mycothiol for growth in vitro and in vivo, and provide a novel mechanism of ethionamide resistance in M. tuberculosis...
  76. ncbi An autocrine insulin feedback loop maintains pancreatic beta-cell 3-phosphorylated inositol lipids
    Jia Yu
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institute, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Mol Endocrinol 21:2775-84. 2007
    ..Fewer data are available on the 3-phosphorylated inositol lipids (3-PIs) that are the primary products of these kinases...
  77. ncbi Inositol augmentation of lithium or valproate for bipolar depression
    A Eden Evins
    Harvard Bipolar Research Program and Department of Psychiatry of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:168-74. 2006
    ..Up to half of patients do not respond adequately to currently approved treatments. This study evaluated the efficacy of adjunctive inositol for bipolar depression.
  78. ncbi Homozygote inositol transporter knockout mice show a lithium-like phenotype
    Yuly Bersudsky
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Bipolar Disord 10:453-9. 2008
    Lithium inhibits inositol monophosphatase and also reduces inositol transporter function. To determine if one or more of these mechanisms might underlie the behavioral effects of lithium, we studied inositol transporter knockout mice...
  79. doi Inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs
    Pietro Cavalli
    Birth Defects Res A Clin Mol Teratol 82:540-2. 2008
  80. ncbi Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol
    Abed N Azab
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mol Microbiol 63:1248-58. 2007
    Studies have shown that the inositol biosynthetic pathway and the enzyme glycogen synthase kinase-3 (GSK-3) are targets of the mood-stabilizing drugs lithium and valproate...
  81. pmc Structural and biophysical characterization of human myo-inositol oxygenase
    Ann Gerd Thorsell
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 283:15209-16. 2008
    Altered inositol metabolism is implicated in a number of diabetic complications...
  82. ncbi Significance of subnuclear localization of key players of inositol lipid cycle
    Lucio Cocco
    Cellular Signaling Laboratory, Department of Anatomical Sciences, University of Bologna, Via Irnerio 48, Bologna 40126, Italy
    Adv Enzyme Regul 44:51-60. 2004
  83. ncbi Quantitative proton MRS of Pelizaeus-Merzbacher disease: evidence of dys- and hypomyelination
    F A Hanefeld
    Abteilung Kinderheilkunde, Schwerpunkt Neuropadiatrie, Gottingen, Germany
    Neurology 65:701-6. 2005
    ..MRI reveals loss of T1 contrast between gray and affected white matter and T2 hyperintensities of white matter due to elevated water content...
  84. pmc Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome
    Ken ichi Yoshida
    Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, 1 1 Rokkodai, Kobe, Hyogo 657 8501, Japan
    Appl Environ Microbiol 72:1310-5. 2006
    D-chiro-inositol (DCI) is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome, since it improves the efficiency with which the body uses insulin and also promotes ovulation...
  85. ncbi Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol
    P D Carey
    MRC Research Unit for Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Metab Brain Dis 19:125-34. 2004
    b>Inositol, a glucose isomer and second messenger precursor, regulates numerous cellular functions and has demonstrated efficacy in obsessive-compulsive disorder (OCD) through mechanisms that remain unclear...
  86. ncbi myo-Inositol and sucrose concentrations affect the accumulation of raffinose family oligosaccharides in seeds
    Ute Karner
    Institute of Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    J Exp Bot 55:1981-7. 2004
    ..Galactinol synthase (GolS), which mediates the synthesis of galactinol from myo-inositol and UDP-galactose, has been proposed to be the key enzyme of the pathway...
  87. pmc Lithium treatment effects on Myo-inositol in adolescents with bipolar depression
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
    Biol Psychiatry 60:998-1004. 2006
    ..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression.
  88. ncbi Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study
    Felix Beacher
    Section of Brain Maturation, Department of Psychological Medicine, Neuroimaging Research Group, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, England, UK
    Arch Gen Psychiatry 62:1360-5. 2005
    ..However, the biological determinants of this are poorly understood. The serum sodium/myo-inositol cotransporter gene is located on chromosome 21, and myo-inositol affects neuronal survival and function...
  89. ncbi SMIT2 mediates all myo-inositol uptake in apical membranes of rat small intestine
    Rym Aouameur
    Groupe d étude des protéines membranaires GÉPROM, Departement de Physiologie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada, H3C 3J7
    Am J Physiol Gastrointest Liver Physiol 293:G1300-7. 2007
    This study presents the characterization of myo-inositol (MI) uptake in rat intestine as evaluated by use of purified membrane preparations...
  90. pmc PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor
    Yoshiko Murakami
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Mol Biol Cell 14:4285-95. 2003
    ..The inositol ring of phosphatidylinositol is acylated during biosynthesis of GPI...
  91. pmc Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
    Nicolas Fayed
    Department of Radiology, Hospital Quiron, Paseo de Mariano Renovales, Zaragoza, Spain
    Arthritis Res Ther 12:R134. 2010
    ..We also searched for correlations between neuroimaging abnormalities and neuropsychological variables...
  92. ncbi Involvement of inositol in reproduction
    Patricia Beemster
    Department of Epidemiology, University Medical Centre Nijmegen, The Netherlands
    Nutr Rev 60:80-7. 2002
    b>Inositol is involved in several aspects of reproduction. It affects overall embryogenesis, may prevent neural tube defects, and stimulates the production of lung surfactant...
  93. doi Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients
    Ebrahim Haroon
    Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 171:10-9. 2009
    ..Myo-inositol (mI), a neuronal/glial metabolite associated with multiple functions in the brain, has been shown to be increased ..
  94. pmc D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Int J Exp Diabetes Res 3:47-60. 2002
    In this review we discuss the biological significance of D-chiro-inositol, originally discovered as a component of a putative mediator of intracellular insulin action, where as a putative mediator, it accelerates the dephosphorylation of ..
  95. pmc Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1
    Abel R Alcázar-Román
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8240, USA
    J Biol Chem 285:16683-92. 2010
    ..At the cytoplasmic side of the NPC, the conserved mRNA export factors Gle1 and inositol hexakisphosphate (IP(6)) play an essential role in mRNA export by activating the ATPase activity of the DEAD-box ..
  96. ncbi Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder
    A Palatnik
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel
    J Clin Psychopharmacol 21:335-9. 2001
    ..myo-Inositol, a natural isomer of glucose and a precursor for the second-messenger phosphatidyl-inositol system, has ..
  97. pmc Evaluation of expression and function of the H+/myo-inositol transporter HMIT
    Elena Di Daniel
    Psychiatry Discovery Technology Group, GlaxoSmithKline, New Frontiers Science Park, Harlow, UK
    BMC Cell Biol 10:54. 2009
    ..been shown to inhibit key enzymes that regulate PIns production and alter neuronal growth cone morphology in an inositol-reversible manner...
  98. doi PtdIns(3,4,5)P(3) and inositol depletion as a cellular target of mood stabilizers
    Regina Teo
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK
    Biochem Soc Trans 37:1110-4. 2009
    ..In the 1980s, Berridge and colleagues proposed that Li(+) treatment acts via inhibition of IMPase (inositol monophosphatase) to deplete the cellular concentration of myo-inositol...
  99. ncbi The pssB gene product of Rhizobium leguminosarum bv. trifolii is homologous to a family of inositol monophosphatases
    M Janczarek
    Department of General Microbiology, M Curie Sklodowska University, Lublin, Poland
    FEMS Microbiol Lett 173:319-25. 1999
    ..A mutant strain was also defective in nitrogen fixation suggesting a regulatory role of pssB in symbiosis with clover...
  100. ncbi Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome
    J E Nestler
    Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0111, USA
    N Engl J Med 340:1314-20. 1999
    ..ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin...
  101. ncbi Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol
    H Jyonouchi
    Department of Pediatrics, University of Minnesota, School of Medicine, UMHC, Minneapolis 55455, USA
    Carcinogenesis 20:139-45. 1999
    ..Tumorigenesis is inhibited by dietary myo-inositol in the post-initiation phase...

Research Grants86

  1. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2010
    ..mannosyltransferase;MPI, mannosylated phosphatidylinositol;MS, mass spectrometry;myo-Ins, myo-inositol;ORF, open reading frame;investigator, phosphatidyl-myo-inositol;PIM, phosphatidyl-myo-inositol mannosides;TFA, ..
  2. GATING AND TRANSLOCATION IN THE DIPHTHERIA TOXIN CHANNEL
    Bruce Kagan; Fiscal Year: 1990
    ..1. Pharmacology of DT gating. The intracellular second messenger 1,4,5-inositol-triphosphate (IP3) bind to DT and stimulates channel formation from the trans side of the membrane...
  3. GATING AND TRANSLOCATION IN THE DIPHTHERIA TOXIN CHANNEL
    Bruce Kagan; Fiscal Year: 1992
    ..1. Pharmacology of DT gating. The intracellular second messenger 1,4,5-inositol-triphosphate (IP3) bind to DT and stimulates channel formation from the trans side of the membrane...
  4. PANCREATIC SECRETION AND PHOSPHATIDYLINOSITOL METABOLISM
    Stephen Pandol; Fiscal Year: 1990
    ..studies indicate agents cause hydrolysis of membrane phosphoinositides to 1,2 diacylglycerol (1,2 DAG) and inositol phosphates...
  5. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1990
    ..g. 3H-inositol, 14C-arachidonic acid, 32P) to label phospholipids, inositol polyphosphates, arachidonic acid metabolites, and ..
  6. Mood-Stabilizing Medications and the Inositol Signaling System
    Ranga N Parthasarathy; Fiscal Year: 2011
    ..Lithium inhibits brain inositol monophosphatase (IMPase), thereby depleting the available pool of free inositol, and resulting in the correction ..
  7. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2009
    ..We found that oral R-flurbiprofen is well tolerated and detectable in transgenic mouse brain. Scyllo-inositol, an isomer of cyclohexanahexol, inhibits A[unreadable] oligomers formation and, when orally administered to AD ..
  8. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2010
    ..We found that oral R-flurbiprofen is well tolerated and detectable in transgenic mouse brain. Scyllo-inositol, an isomer of cyclohexanahexol, inhibits A[unreadable] oligomers formation and, when orally administered to AD ..
  9. Role of Phospholipase C in Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The long-term goal of our laboratory is to elucidate the role of inositol polyphosphates (InsPs) in transcriptional regulation...
  10. STUDY OF GAMMA GLOBULIN STRUCTURE AND HYPERSENSITIVITY
    Kimishige Ishizaka; Fiscal Year: 1990
    ..IgE antibody molecules by multivalent ligand induced activation of phospholipase C (PLC) for hydrolysis of inositol phospholipids, and that this process may play a major role in the transduction of triggering signals for mediator ..
  11. Molecular T. vaginalis-host interactions in relevance to inflammatory sequelae
    Raina N Fichorova; Fiscal Year: 2010
    ..LPG is a glycosylphosphatidyl inositol-like anchored molecule, which unlike other GPI-like parasitic molecules, contains no mannose and has poly-N-..
  12. Molecular T. vaginalis-host interactions in relevance to inflammatory sequelae
    Raina Fichorova; Fiscal Year: 2009
    ..LPG is a glycosylphosphatidyl inositol-like anchored molecule, which unlike other GPI-like parasitic molecules, contains no mannose and has poly-N-..
  13. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2000
    ..neurotransmitters, growth factors, and other stimuli produce their physiological effects by stimulation of inositol lipid breakdown...
  14. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 1999
    ..neurotransmitters, growth factors, and other stimuli produce their physiological effects by stimulation of inositol lipid breakdown...
  15. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2002
    ..neurotransmitters, growth factors, and other stimuli produce their physiological effects by stimulation of inositol lipid breakdown...
  16. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 1993
    ..neurotransmitters, growth factors, and other stimuli produce their physiological effects by stimulation of inositol lipid breakdown...
  17. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2001
    ..neurotransmitters, growth factors, and other stimuli produce their physiological effects by stimulation of inositol lipid breakdown...
  18. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2001
    ..the cleavage of phosphoinositides to diacylglycerol (a second messenger activator of protein kinase C) and inositol phosphates...
  19. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2003
    ..the cleavage of phosphoinositides to diacylglycerol (a second messenger activator of protein kinase C) and inositol phosphates...
  20. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2002
    ..the cleavage of phosphoinositides to diacylglycerol (a second messenger activator of protein kinase C) and inositol phosphates...
  21. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2000
    ..the cleavage of phosphoinositides to diacylglycerol (a second messenger activator of protein kinase C) and inositol phosphates...
  22. Structure-Function Analysis of Leishmania MIT
    Andreas Seyfang; Fiscal Year: 2006
    ..In these protozoan flagellates, myo-inositol plays an especially important role as the precursor for GPI-anchored protective and/or immunomodulatory surface ..
  23. Structure-Function Analysis of Leishmania MIT
    Andreas Seyfang; Fiscal Year: 2005
    ..In these protozoan flagellates, myo-inositol plays an especially important role as the precursor for GPI-anchored protective and/or immunomodulatory surface ..
  24. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 1990
    ..While knowledge of the biochemical sequelae resulting from inositol-1,4,5 P3 and diacylglycerol formation has advanced markedly in recent years, the receptor-initiated trans-plasma ..
  25. BRAIN PHOSPHOINOSITIDES AND BARBITURATES
    DIWAKAR DESHMUKH; Fiscal Year: 1991
    ..Among lipophilic drugs, the barbiturates are the nearest in structure to inositol; both contain a six-membered ring with several hydrogen bonding sites (O, OH, or NH groups)...
  26. BRAIN PHOSPHOINOSITIDES AND BARBITURATES
    DIWAKAR DESHMUKH; Fiscal Year: 1993
    ..Among lipophilic drugs, the barbiturates are the nearest in structure to inositol; both contain a six-membered ring with several hydrogen bonding sites (O, OH, or NH groups)...
  27. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2005
    Many extracellular stimuli produce their physiological effects through promotion of inositol lipid hydrolysis...
  28. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2004
    Many extracellular stimuli produce their physiological effects through promotion of inositol lipid hydrolysis...
  29. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2007
    Many extracellular stimuli produce their physiological effects through promotion of inositol lipid hydrolysis...
  30. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2007
    Many extracellular stimuli produce their physiological effects through promotion of inositol lipid hydrolysis...
  31. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2006
    Many extracellular stimuli produce their physiological effects through promotion of inositol lipid hydrolysis...
  32. Coupling of D-chiro-inositol to insulin in PCOS women
    MARIA IUORNO; Fiscal Year: 2003
    ..The cellular mechanisms of insulin resistance in PCOS are still largely unknown. D-chiro-inositol phosphoglycan (DCI-IPG) is a nonclassical mediator of insulin action that has been demonstrated to increase ..
  33. CONTROL OF PHOSPHOLIPASE C IN V-SRC TRANSFORMED CELLS
    James Garrison; Fiscal Year: 2002
    ..as exemplified by growth factor receptors and expression of non-receptor kinases such as pp60v-src can stimulate inositol lipid breakdown and generate signals such as diacylglycerol (DAG) and Ca2+ within the cell...
  34. CONTROL OF PHOSPHOLIPASE C IN V-SRC TRANSFORMED CELLS
    James Garrison; Fiscal Year: 2002
    ..as exemplified by growth factor receptors and expression of non-receptor kinases such as pp60v-src can stimulate inositol lipid breakdown and generate signals such as diacylglycerol (DAG) and Ca2+ within the cell...
  35. Coupling of D-chiro-inositol to insulin in PCOS women
    MARIA IUORNO; Fiscal Year: 2004
    ..The cellular mechanisms of insulin resistance in PCOS are still largely unknown. D-chiro-inositol phosphoglycan (DCI-IPG) is a nonclassical mediator of insulin action that has been demonstrated to increase ..
  36. CONTROL OF PHOSPHOLIPASE C IN V-SRC TRANSFORMED CELLS
    James Garrison; Fiscal Year: 2001
    ..as exemplified by growth factor receptors and expression of non-receptor kinases such as pp60v-src can stimulate inositol lipid breakdown and generate signals such as diacylglycerol (DAG) and Ca2+ within the cell...
  37. CONTROL OF PHOSPHOLIPASE C IN V-SRC TRANSFORMED CELLS
    James Garrison; Fiscal Year: 2001
    ..as exemplified by growth factor receptors and expression of non-receptor kinases such as pp60v-src can stimulate inositol lipid breakdown and generate signals such as diacylglycerol (DAG) and Ca2+ within the cell...
  38. CONTROL OF PHOSPHOLIPASE C IN V-SRC TRANSFORMED CELLS
    James Garrison; Fiscal Year: 1999
    ..as exemplified by growth factor receptors and expression of non-receptor kinases such as pp60v-src can stimulate inositol lipid breakdown and generate signals such as diacylglycerol (DAG) and Ca2+ within the cell...
  39. CONTROL OF PHOSPHOLIPASE C IN V-SRC TRANSFORMED CELLS
    James Garrison; Fiscal Year: 2000
    ..as exemplified by growth factor receptors and expression of non-receptor kinases such as pp60v-src can stimulate inositol lipid breakdown and generate signals such as diacylglycerol (DAG) and Ca2+ within the cell...
  40. FUNCTIONAL CHARACTERIZATION OF LEISHMANIA TRANSPORTER
    Scott Landfear; Fiscal Year: 2000
    ..In this proposal we will study the role of three membrane transporters, those for glucose, myo-inositol and nucleosides, in the biology of Leishmania parasites...
  41. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2010
    ..receptor densities do not support aromatase expression because they also stimulate the accumulation of inositol phosphates and diacylglycerol leading to the release of epiregulin and phosphorylation of EGFR and ERK1/2...
  42. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2011
    ..receptor densities do not support aromatase expression because they also stimulate the accumulation of inositol phosphates and diacylglycerol leading to the release of epiregulin and phosphorylation of EGFR and ERK1/2...
  43. FUNCTIONAL CHARACTERIZATION OF LEISHMANIA TRANSPORTER
    Scott Landfear; Fiscal Year: 1999
    ..In this proposal we will study the role of three membrane transporters, those for glucose, myo-inositol and nucleosides, in the biology of Leishmania parasites...
  44. PATHOGENESIS OF DIABETIC NEPHROPATHY
    Yashpal S Kanwar; Fiscal Year: 2012
    ..e., myo- inositol oxygenase (MIOX), in tubulo-interstitial pathobiology in the context of diabetic nephropathy (DN)...
  45. AFFINITY LABELS FOR INOSITOL POLYPHOSPHATE RECEPTORS
    Glenn Prestwich; Fiscal Year: 1999
    ..The second messenger D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3, or IP3) binds stereospecifically to domains of membrane receptors to cause ..
  46. AFFINITY LABELS FOR INOSITOL POLYPHOSPHATE RECEPTORS
    Glenn Prestwich; Fiscal Year: 1992
    ..The second messenger D-myo-inositol 1,4,5- trisphosphate (Ins(1,4,5)P3, hereafter IP3) interacts stereospecifically with membrane receptors to ..
  47. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2004
    ..is to elucidate how diverse extracellular stimuli elicit selective cellular responses through the activation of inositol polyphosphate (IP) signaling pathways...
  48. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2004
    ..is to elucidate how diverse extracellular stimuli elicit selective cellular responses through the activation of inositol polyphosphate (IP) signaling pathways...
  49. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2005
    ..is to elucidate how diverse extracellular stimuli elicit selective cellular responses through the activation of inositol polyphosphate (IP) signaling pathways...
  50. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2003
    ..is to elucidate how diverse extracellular stimuli elicit selective cellular responses through the activation of inositol polyphosphate (IP) signaling pathways...
  51. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2002
    ..is to elucidate how diverse extracellular stimuli elicit selective cellular responses through the activation of inositol polyphosphate (IP) signaling pathways...
  52. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2001
    ..is to elucidate how diverse extracellular stimuli elicit selective cellular responses through the activation of inositol polyphosphate (IP) signaling pathways...
  53. OCRL and the pathogenesis of Lowe Syndrome and Dent Disease
    Pietro De Camilli; Fiscal Year: 2009
    ..syndrome of Lowe (Lowe syndrome) and Dent disease, which result from mutations in the gene encoding the inositol 5-phosphatase OCRL...
  54. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2005
    ..volume, cells release Kv, CI-, and "non-perturbing" organic osmolytes, a major component of which is myo-inositol. Efflux of the osmolytes occurs via a volume-sensitive organic anion channel (VSOAC), which primarily gates CI'...
  55. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..volume, cells release Kv, CI-, and "non-perturbing" organic osmolytes, a major component of which is myo-inositol. Efflux of the osmolytes occurs via a volume-sensitive organic anion channel (VSOAC), which primarily gates CI&..
  56. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2003
    ..volume, cells release Kv, CI-, and "non-perturbing" organic osmolytes, a major component of which is myo-inositol. Efflux of the osmolytes occurs via a volume-sensitive organic anion channel (VSOAC), which primarily gates CI'...
  57. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2004
    ..volume, cells release Kv, CI-, and "non-perturbing" organic osmolytes, a major component of which is myo-inositol. Efflux of the osmolytes occurs via a volume-sensitive organic anion channel (VSOAC), which primarily gates CI'...
  58. RETINAL MICROVESSELS BASIS FOR INJURY IN DIABETES
    Gary Goldstein; Fiscal Year: 1990
    ..We believe that intracellular sorbitol may interfere with receptor mediated turnover of inositol phospholipids and subsequent activation of protein kinase C and this may, in part, underlie the microangiopathy...
  59. INTERACTIONS AND ACTIVATION OF THE FSH RECEPTOR
    TAE JI; Fiscal Year: 2001
    ..study of interaction between FSHR and FSH and subsequent generation of signals for second messengers, cAMP and inositol phosphates...
  60. INTERACTIONS AND ACTIVATION OF THE FSH RECEPTOR
    TAE JI; Fiscal Year: 2002
    ..study of interaction between FSHR and FSH and subsequent generation of signals for second messengers, cAMP and inositol phosphates...
  61. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2003
    ..by putative inositolphosphoglycan (IPG) mediators of insulin action and a deficiency in a specific D-chiro-inositol-containing IPG may contribute to insulin resistance in individuals with impaired glucose tolerance or type 2 ..
  62. Structural study of enzymes of inositol biosynthesis
    Boguslaw Stec; Fiscal Year: 2002
    ..More specifically, we are interested in enzymes involved in the synthesis of myo-inositol. Myo-inositol is generated by the conversion of D-glucose-6- in enzymes involved in the synthesis of myo-inositol ..
  63. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2002
    ..by putative inositolphosphoglycan (IPG) mediators of insulin action and a deficiency in a specific D-chiro-inositol-containing IPG may contribute to insulin resistance in individuals with impaired glucose tolerance or type 2 ..
  64. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2001
    ..by putative inositolphosphoglycan (IPG) mediators of insulin action and a deficiency in a specific D-chiro-inositol-containing IPG may contribute to insulin resistance in individuals with impaired glucose tolerance or type 2 ..
  65. CONTROL OF METABOLISM IN NORMAL AND DISEASE STATES
    John Williamson; Fiscal Year: 1990
    ..polyphosphates in the plasma membrane with a simultaneous production of the Ca2+ -mobilizing second messenger, inositol 1, 4,5-trisphosphate, and the protein kinase C activator, 1,2-diacylglycerol...
  66. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2004
    ..by putative inositolphosphoglycan (IPG) mediators of insulin action and a deficiency in a specific D-chiro-inositol-containing IPG may contribute to insulin resistance in individuals with impaired glucose tolerance or type 2 ..
  67. IONIC REGULATION IN THE ACTIVATION OF DEVELOPMENT
    Richard Nuccitelli; Fiscal Year: 1990
    ..This comes under two main headings: 1) studies of the inositol lipid cascade and its role in Ca2+ release; 2) studies of the pHi and (Ca2+)i changes and interactions following ..
  68. EFFECT OF TSH ON THYROID METABOLISM
    WILLIAM DEERY; Fiscal Year: 1990
    ..Hydrolysis of phosphatidylinositol 4,5 bisphosphate (PIP2) with formation of inositol trisphosphate (IP3) and diacylglycerol is another intracellular signalling system in many tissues...
  69. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2007
    ..the cleavage of phosphoinositides to diacylglycerol (a second messenger activator of protein kinase C), and inositol phosphates (cyclic 1,2-inositol phosphate in the case of bacterial PI-PLC and both cIP and inositol-1-phosphate ..
  70. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2005
    ..the cleavage of phosphoinositides to diacylglycerol (a second messenger activator of protein kinase C), and inositol phosphates (cyclic 1,2-inositol phosphate in the case of bacterial PI-PLC and both cIP and inositol-1-phosphate ..
  71. AGE RELATED CHANGES IN PITUITARY LACTOTROPHS
    Phyllis Callahan; Fiscal Year: 1991
    ..will be on the cell signal transduction mechanism of the lactotroph, specifically the hydrolysis of phosphatidyl-inositol-4,5- bisphosphate (PIP2)...