inositol

Summary

Summary: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.

Top Publications

  1. pmc Lithium induces autophagy by inhibiting inositol monophosphatase
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, England, UK
    J Cell Biol 170:1101-11. 2005
  2. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
  3. ncbi Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism
    Barry P Young
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Science 329:1085-8. 2010
  4. ncbi Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704)
    Deepak Singh
    Department of Biological Science, Institute of Bioscience and Biotechnology, Myongji University, Yongin, 449 728, Republic of Korea
    Gene 376:13-23. 2006
  5. ncbi Myo-inositol and beyond--emerging networks under stress
    Ravi Valluru
    Ecophysiology of Plants Under Environmental Stress, INRA SUPAGRO, Institute of Integrative Plant Biology, 2 place Viala, Montpellier, France
    Plant Sci 181:387-400. 2011
  6. ncbi High-affinity myo-inositol transport in Candida albicans: substrate specificity and pharmacology
    Jean Huaqian Jin
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2100, USA
    Microbiology 149:3371-81. 2003
  7. pmc Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases
    Thai Leong Yap
    Laboratory of Molecular Biophysics, National Heart Lung and Blood Institute, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:28080-8. 2011
  8. ncbi Inositol derivatives: evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Mol Cell Biol 9:151-61. 2008
  9. pmc Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice
    Shuang Qing Chen
    Department of Radiology, Tongji Hospital, Tongji University, Shanghai, China
    Dement Geriatr Cogn Disord 28:558-66. 2009
  10. pmc Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling
    E B Rodriguez de Turco
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 98:4740-5. 2001

Research Grants

  1. PTEN TUMOR SUPPRESSOR AND SIGNAL TRANSDUCTION
    RAMON E PARSONS; Fiscal Year: 2012
  2. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
  3. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
  4. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
  5. GILZ Regulation of ENaC
    David Pearce; Fiscal Year: 2012
  6. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
  7. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
  8. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
  9. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
  10. ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTOR
    J Kevin Foskett; Fiscal Year: 2013

Detail Information

Publications303 found, 100 shown here

  1. pmc Lithium induces autophagy by inhibiting inositol monophosphatase
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, England, UK
    J Cell Biol 170:1101-11. 2005
    ..The autophagy-enhancing properties of lithium were mediated by inhibition of inositol monophosphatase and led to free inositol depletion...
  2. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
    The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular activities...
  3. ncbi Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism
    Barry P Young
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Science 329:1085-8. 2010
    ..This enabled coupling of membrane biogenesis to nutrient availability...
  4. ncbi Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704)
    Deepak Singh
    Department of Biological Science, Institute of Bioscience and Biotechnology, Myongji University, Yongin, 449 728, Republic of Korea
    Gene 376:13-23. 2006
    ..This promises excellent opportunities to elucidate biosynthetic route(s) to the validamycin complex and to engineer the pathway for industrial application...
  5. ncbi Myo-inositol and beyond--emerging networks under stress
    Ravi Valluru
    Ecophysiology of Plants Under Environmental Stress, INRA SUPAGRO, Institute of Integrative Plant Biology, 2 place Viala, Montpellier, France
    Plant Sci 181:387-400. 2011
    Myo-inositol is a versatile compound that generates diversified derivatives upon phosphorylation by lipid-dependent and -independent pathways...
  6. ncbi High-affinity myo-inositol transport in Candida albicans: substrate specificity and pharmacology
    Jean Huaqian Jin
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2100, USA
    Microbiology 149:3371-81. 2003
    b>Inositol is considered a growth factor in yeast cells and it plays an important role in Candida as an essential precursor for phospholipomannan, a glycophosphatidylinositol (GPI)-anchored glycolipid on the cell surface of Candida which is ..
  7. pmc Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases
    Thai Leong Yap
    Laboratory of Molecular Biophysics, National Heart Lung and Blood Institute, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:28080-8. 2011
    ....
  8. ncbi Inositol derivatives: evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Mol Cell Biol 9:151-61. 2008
    Current research on inositols mainly focuses on myo-inositol (Ins) derivatives in eukaryotic cells, and in particular on the many roles of Ins phospholipids and polyphosphorylated Ins derivatives...
  9. pmc Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice
    Shuang Qing Chen
    Department of Radiology, Tongji Hospital, Tongji University, Shanghai, China
    Dement Geriatr Cogn Disord 28:558-66. 2009
    To explore the potential value of myo-inositol (mIns), which is regarded as a biomarker for early diagnosis of Alzheimer's disease, in APP/PS1 transgenic (tg) mice detected by (1)H-MRS.
  10. pmc Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling
    E B Rodriguez de Turco
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 98:4740-5. 2001
    ..We propose that DGKepsilon contributes to modulate neuronal signaling pathways linked to synaptic activity, neuronal plasticity, and epileptogenesis...
  11. ncbi How do inositol and glucose modulate feeding in Manduca sexta caterpillars?
    J I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
    J Exp Biol 203:1299-315. 2000
    Many species of caterpillar possess taste cells that respond exceptionally vigorously to the sugar alcohol myo-inositol. We examined the functional significance of these inositol-sensitive taste cells in Manduca sexta caterpillars through ..
  12. pmc Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01
    Sharmistha Sinha
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    ACS Chem Neurosci 3:451-8. 2012
    ..Two such compounds, the natural inositol derivative scyllo-inositol and the green-tea-derived flavonoid epigallocatechin gallate (EGCG), currently are in ..
  13. pmc In Silico identification of pathogenic strains of Cronobacter from Biochemical data reveals association of inositol fermentation with pathogenicity
    Stephen E Hamby
    School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK
    BMC Microbiol 11:204. 2011
    ..Therefore to be able to differentiate between the pathogenic and non-pathogenic strains is of interest to the food industry and regulators...
  14. ncbi Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, M5S 3H2, Canada
    J Biol Chem 275:18495-502. 2000
    b>Inositol has 8 stereoisomers, four of which are physiologically active. myo-Inositol is the most abundant isomer in the brain and more recently shown that epi- and scyllo-inositol are also present...
  15. pmc VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants
    Javad Torabinejad
    Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
    Plant Physiol 150:951-61. 2009
    ..Analysis of metabolite levels in vtc4 mutants showed that less myoinositol and ascorbate accumulate in these mutants. Therefore, VTC4 is a bifunctional enzyme that impacts both myoinositol and ascorbate synthesis pathways...
  16. ncbi Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Nat Med 9:1513-9. 2003
    ..Spina bifida in ct/ct mice is folate resistant, but its incidence can be markedly reduced by maternal inositol supplementation periconceptually...
  17. ncbi Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism
    Amy B Manning-Bog
    The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085, USA
    Neurotoxicology 30:1127-32. 2009
    ....
  18. ncbi Mycothiol: a target for potentiation of rifampin and other antibiotics against Mycobacterium tuberculosis
    Marcy Hernick
    Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Expert Rev Anti Infect Ther 11:49-67. 2013
    ....
  19. ncbi Importance and regulation of inositol biosynthesis during growth and differentiation of Streptomyces
    Guohua Zhang
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Mol Microbiol 83:1178-94. 2012
    Unusually among bacteria, actinobacteria possess myo-inositol 1-phosphate synthase (mIPS). In the developmentally complex Streptomyces coelicolor, the mIPS-encoding gene (inoA) is cotranscribed with a putative regulatory gene (inoR)...
  20. pmc N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI)
    Jerzy Walecki
    Department of Radiology, Medical Centre of Postgraduate Education, Warsaw, Poland
    Med Sci Monit 17:MT105-11. 2011
    ..Purpose of study was evaluation of regional metabolic disorders using 1H MRS in patients with MCI, as a predictor of clinical conversion to dementia based on clinical follow-up...
  21. ncbi Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
    Alessandro D Genazzani
    Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Italy
    Gynecol Endocrinol 24:139-44. 2008
    To evaluate the effects the administration of myo-inositol (MYO) on hormonal parameters in a group of PCOS patients.
  22. ncbi THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover
    Andrew Pierce
    Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Br J Haematol 141:641-50. 2008
    ..Thus, THOC5 is a novel target for modulation of signal transduction with a potential role in leukaemogenesis...
  23. pmc Characterization of myo-inositol utilization by Corynebacterium glutamicum: the stimulon, identification of transporters, and influence on L-lysine formation
    Eva Krings
    Institute of Biotechnology, Research Centre Juelich, D 52425 Juelich, Germany
    J Bacteriol 188:8054-61. 2006
    ..possess genes annotated iol in their genomes, there have been very few studies on the possibly associated myo-inositol metabolism and its significance for the cell...
  24. ncbi Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
    Stephen K Fisher
    Mental Health Research Institute, and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurochem 82:736-54. 2002
    b>Inositol phospholipids and inositol phosphates mediate well-established functions in signal transduction and in Ca2+ homeostasis in the CNS and non-neural tissues...
  25. ncbi Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombe
    C Niederberger
    Institute of General Microbiology, University of Bern, Switzerland
    Curr Genet 33:255-61. 1998
    Fission yeast, Schizosaccharomyces pombe, is a natural inositol auxotroph. We show here that the amount of exogenous inositol added to the medium is critical for the control of its life cycle...
  26. pmc Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla
    Lana G Kaiser
    Department of Radiology, University of California San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA
    NMR Biomed 18:51-5. 2005
    The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T...
  27. ncbi High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism
    A Viola
    Centre de Résonance Magnétique, Biologique et Médicale UMR CNRS 6612, Faculte de Medecine, 27 Bd J Moulin, 13005 Marseille, France
    MAGMA 17:47-61. 2004
    ..tested the hypothesis that chronic alcoholics exhibit profound alterations in the cerebral metabolism of scyllo-inositol. Brain metabolism was explored in nine actively drinking and 11 recently detoxified chronic alcoholics by in vivo ..
  28. ncbi Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial
    P Rizzo
    Department of Obstetrics and Gynecology, University of Messina, Messina, Italy
    Eur Rev Med Pharmacol Sci 14:555-61. 2010
    The aim of the study was to evaluate the efficacy of a treatment with myo-inositol plus folic acid plus melatonin compared with myo-inositol plus folic acid alone on oocyte quality in women underwent in vitro fertilization (IVF) cycles.
  29. ncbi Inositol induces a profound alteration in the pattern and rate of synthesis and turnover of membrane lipids in Saccharomyces cerevisiae
    Maria L Gaspar
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, NY 14853, USA
    J Biol Chem 281:22773-85. 2006
    The addition of inositol to actively growing yeast cultures causes a rapid increase in the rate of synthesis of phosphatidylinositol and, simultaneously, triggers changes in the expression of hundreds of genes...
  30. pmc D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis
    Yu Luo
    State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, People s Republic of China
    Plant Cell 23:1352-72. 2011
    In animal cells, myo-inositol is an important regulatory molecule in several physiological and biochemical processes, including signal transduction and membrane biogenesis...
  31. ncbi 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders
    Lidia Gabis
    Weinberg Child Development Center, Safra Children s Hospital, Tel Hashomer, Israel
    J Child Neurol 23:766-74. 2008
    ..lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions...
  32. ncbi IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity
    Kim Cryns
    Research and Early Development Europe, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Neuropsychopharmacology 33:674-84. 2008
    ..Intriguingly, the embryonic lethality could be reversed by myo-inositol supplementation via the pregnant mothers...
  33. pmc Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    J Affect Disord 119:186-9. 2009
    ..Frontal Glx levels appear to be normalised after recovery from depression, but it is not known if this composite measure masks ongoing differences in glutamate or glutamine alone...
  34. pmc Down-regulation of the myo-inositol oxygenase gene family has no effect on cell wall composition in Arabidopsis
    Stefanie Endres
    Department of Cell Biology, Plant Physiology, University of Salzburg, Hellbrunnerstr 34, 5020 Salzburg, Austria
    Planta 234:157-69. 2011
    The enzyme myo-inositol oxygenase (MIOX; E.C. 1.13.99...
  35. pmc Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
    Thanyarat Promlek
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Biol Cell 22:3520-32. 2011
    ..In contrast, this mutant was activated like wild-type Ire1 by depletion of the membrane lipid component inositol or by deletion of genes involved in lipid homeostasis...
  36. pmc Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis
    Shumpei Asamizu
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Am Chem Soc 133:12124-35. 2011
    ..The enzyme operates in sequence with a phosphatase, which dephosphorylates validoxylamine A 7'-phosphate to validoxylamine A...
  37. ncbi Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge, UK
    Autophagy 2:132-4. 2006
    We recently showed that lithium induces autophagy via inositol monophosphatase (IMPase) inhibition, leading to free inositol depletion and reduced myo-inositol-1,4, 5-triphosphate (IP3) levels...
  38. pmc Two major inositol transporters and their role in cryptococcal virulence
    Yina Wang
    Public Health Research Institute, University of Medicine and Dentistry of New Jersey, ICPH Building, Room W250H, 225 Warren Street, Newark, NJ 07103, USA
    Eukaryot Cell 10:618-28. 2011
    ..The existence of high inositol concentrations in brain and our earlier discovery of a large inositol transporter (ITR) gene family in C...
  39. pmc Topological and functional characterization of an insect gustatory receptor
    Hui jie Zhang
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing, China
    PLoS ONE 6:e24111. 2011
    ..functions independently in Sf9 cells and responds in a concentration-dependent manner to the polyalcohols myo-inositol and epi-inositol but not to a range of mono- and di-saccharides...
  40. pmc The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium
    Pishan Chang
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK
    Dis Model Mech 5:115-24. 2012
    ..and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis...
  41. pmc Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis
    Catherine Vilcheze
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Microbiol 69:1316-29. 2008
    ..Mutations in mshA demonstrate the non-essentiality of mycothiol for growth in vitro and in vivo, and provide a novel mechanism of ethionamide resistance in M. tuberculosis...
  42. pmc The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death
    Janet L Donahue
    Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
    Plant Cell 22:888-903. 2010
    l-myo-inositol 1-phosphate synthase (MIPS; EC 5.5.1.4) catalyzes the rate-limiting step in the synthesis of myo-inositol, a critical compound in the cell. Plants contain multiple MIPS genes, which encode highly similar enzymes...
  43. ncbi Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
    Ivana Vucenik
    Department of Medical and Research Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nutr 133:3778S-3784S. 2003
    b>Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells. It was recently recognized to possess multiple biological functions...
  44. ncbi 1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia
    Randall S Jones
    Department of Imaging, Charing Cross Hospital, London, UK
    Neurol Res 26:488-95. 2004
    ..Characteristic and consistent abnormalities in AD are decreased N-acetyl aspartate (NAA) and elevated myo-inositol (mI) in the mesial temporal and parieto-occipital cortex...
  45. pmc Crosstalks between myo-inositol metabolism, programmed cell death and basal immunity in Arabidopsis
    Ping Hong Meng
    Institut de Biotechnologie des Plantes, UMR CNRS 8618, Universite Paris Sud XI, Bat 630, Plateau de Moulon, Orsay, France
    PLoS ONE 4:e7364. 2009
    ..yeast two-hybrid screen using ATXR5 as bait captured AtIPS1, an enzyme which catalyses the committed step of myo-inositol (MI) biosynthesis...
  46. ncbi The role of inositol acylation and inositol deacylation in the Toxoplasma gondii glycosylphosphatidylinositol biosynthetic pathway
    Terry K Smith
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 282:32032-42. 2007
    ..gondii GPI biosynthetic pathway, leading to the observation and characterization of novel inositol-acylated mannosylated GPI intermediates...
  47. ncbi Elevated cerebral glutamate and myo-inositol levels in cognitively normal middle-aged adults with metabolic syndrome
    Andreana P Haley
    Department of Psychology, The University of Texas at Austin, 1 University Station, A8000, Austin, TX 78712, USA
    Metab Brain Dis 25:397-405. 2010
    ..health screen and proton magnetic resonance spectroscopy ((1)H MRS) examining N-acetyl-aspartate (NAA), myo-inositol (mI), creatine (Cr), choline (Cho), and glutamate (Glu) concentrations in occipitoparietal grey matter...
  48. ncbi Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae
    H Shen
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77225, USA
    J Biol Chem 271:29043-8. 1996
    A yeast mutant, cdg1, was isolated on the basis of an inositol excretion phenotype...
  49. pmc Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis
    E F Summers
    Department of Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461
    Genetics 120:909-22. 1988
    ..reduced levels of methylated phospholipids are unable to properly repress synthesis of the cytoplasmic enzyme inositol-1-phosphate synthase...
  50. pmc Organization and transcription of the myo-inositol operon, iol, of Bacillus subtilis
    K I Yoshida
    Department of Biotechnology, Faculty of Engineering, Fukuyama University, Hiroshima, Japan
    J Bacteriol 179:4591-8. 1997
    ..of the iol region of the Bacillus subtilis genome allowed us to predict the structure of the iol operon for myo-inositol catabolism, consisting of 10 iol genes (iolA to iouJ); iolG corresponds to idh, encoding myo-inositol 2-..
  51. ncbi Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48301 Muenster, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:361-4. 2007
    ..To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly measured in ..
  52. ncbi Role of myo-inositol phosphate synthase and sucrose synthase genes in plant seed development
    Ghassen Abid
    Unit of Tropical Crop Husbandry and Horticulture, Gembloux Agricultural University, Passage des Déportés 2, B 5030 Gembloux, Belgium
    Gene 439:1-10. 2009
    The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal ..
  53. ncbi The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum
    Jie Feng
    State Key Laboratory of Microbial Resources at Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    J Biol Chem 281:10778-85. 2006
    ..glutamicum with gentisate or 3-hydroxybenzoate as carbon sources and the first characterization of a mycothiol-dependent maleylpyruvate isomerase...
  54. ncbi Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study
    Vittorio Unfer
    AGUNCO Obstetrics and Gynecology Centre, via G Cassiani, Rome, 15 00155, Italy
    Gynecol Endocrinol 27:857-61. 2011
    ..Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin).
  55. ncbi Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae
    J Nikawa
    Department of Biochemistry, Gunma University School of Medicine, Maebashi, Japan
    J Biol Chem 266:11184-91. 1991
    By the complementation of a yeast mutant defective in myo-inositol transport (Nikawa, J., Nagumo, T., and Yamashita, S. (1982) J. Bacteriol...
  56. ncbi Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial
    L Ciotta
    Microbiological and Gynecological Science Department, Gynecology Section Santo Bambino Hospital Catania, University of Catania, Italy
    Eur Rev Med Pharmacol Sci 15:509-14. 2011
    ..The administration of myo-inositol, a B complex vitamin, was associated with a decreased of serum testosterone and simultaneously, due to its ..
  57. pmc Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast
    Stephen A Jesch
    Department of Molecular Biology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:9106-18. 2005
    ..enzymes of phospholipid biosynthesis are repressed in cells grown in the presence of the phospholipid precursors inositol and choline...
  58. ncbi Myo-inositol prevents copper-induced oxidative damage and changes in antioxidant capacity in various organs and the enterocytes of juvenile Jian carp (Cyprinus carpio var. Jian)
    Wei Dan Jiang
    Animal Nutrition Institute, Sichuan Agricultural University, Ya an, 625014, Sichuan, China
    Aquat Toxicol 105:543-51. 2011
    ..This study assessed the possible protective effects of myo-inositol (MI) against subsequent Cu exposure in juvenile Jian carp (Cyprinus carpio var...
  59. ncbi Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma
    L Schroterova
    Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 500 38 Hradec Kralove, Czech Republic
    Oncol Rep 23:787-93. 2010
    We characterized the effect of phytic acid (inositol hexaphosphate, IP6) as a potential adjuvant in treatment of colorectal carcinoma and evaluated the optimal concentration and treatment time to produe the maximal therapeutic effect...
  60. ncbi Structure-function studies for the panacea, valproic acid
    Nicole Terbach
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK
    Biochem Soc Trans 37:1126-32. 2009
    ..This short review will describe potential therapeutic pathways targeted by VPA, and highlight studies showing structural constraints necessary for these effects...
  61. ncbi Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy
    Antonio Metastasio
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Via Brunamonti 51, 06122 Perugia, Italy
    Neurobiol Aging 27:926-32. 2006
    ..and instrumental assessment, a cerebral 1H MRS scan to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) in the paratrigonal white matter, bilaterally...
  62. pmc In vivo mapping of brain myo-inositol
    Mohammad Haris
    Center for Magnetic Resonance and Optical Imaging CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6100, USA
    Neuroimage 54:2079-85. 2011
    Myo-Inositol (MI) is one of the most abundant metabolites in the human brain located mainly in glial cells and functions as an osmolyte...
  63. ncbi A role for inositol monophosphatase 1 (IMPA1) in salinity adaptation in the euryhaline eel (Anguilla anguilla)
    Svetlana Kalujnaia
    School of Medicine, University of St Andrews, St Andrews, Fife, KY16 9TF, UK
    FASEB J 24:3981-91. 2010
    This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its role in salinity adaptation in the eel...
  64. ncbi Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds
    Jie Liao
    Department of Pathology, Northwestern University, Feinberg School of Medicine 303 East Chicago Avenue, Chicago, IL 60611, USA
    Carcinogenesis 28:446-54. 2007
    ..In order to prevent UC associated carcinogenesis, we tested the effects of inositol compounds (including inositol and hexaphosphate inositol) on UC-associated carcinogenesis in our novel mouse ..
  65. ncbi The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    J Exp Biol 210:3054-67. 2007
    ..Despite eliciting a strong peripheral gustatory response, high concentrations of carbohydrates (e.g. glucose or inositol) stimulate the same intensity of biting as water during 2-min tests...
  66. ncbi Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
    Thomas Tang
    Obstetrics and Gynaecology, Bradford Teaching Hospitals NHS Trust, Bradford, UK
    Cochrane Database Syst Rev 5:CD003053. 2012
    ..Hyperinsulinaemia is associated with an increase in cardiovascular risk and the development of diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating the features of PCOS, including anovulation...
  67. ncbi Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study
    Domenico Giordano
    Policlinico Hospital, Reggio di Calabria, Italy
    Menopause 18:102-4. 2011
    The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women.
  68. ncbi Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 27:21-9. 2011
    ..To compare the efficacy and safety of alogliptin and placebo as add-on therapy in Japanese patients with type 2 diabetes who experienced inadequate glycemic control on voglibose plus diet/exercise therapy...
  69. ncbi Binding of inositol stereoisomers to model amyloidogenic peptides
    Grace Li
    Department of Biochemistry, University of Toronto, 27 King s College Circle, Toronto, Ontario, Canada M5S 1A1
    J Phys Chem B 116:1111-9. 2012
    ..scyllo-Inositol is a stereochemistry-dependent in vitro inhibitor of amyloid formation...
  70. pmc myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol
    R J Arner
    Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, 115 Henning Building, The Pennsylvania State University, University Park, PA 16802, USA
    Biochem J 360:313-20. 2001
    myo-Inositol oxygenase (MIOX) catalyses the first committed step in the only pathway of myo-inositol catabolism, which occurs predominantly in the kidney...
  71. ncbi Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms
    Yasu S Morita
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Biochim Biophys Acta 1810:630-41. 2011
    ..The cell walls of these bacteria have many unique features, including the abundance of various inositol lipids, such as phosphatidylinositol mannosides (PIMs), lipomannan (LM), and lipoarabinomannan (LAM)...
  72. ncbi Inositol and its derivatives: their evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Adv Enzyme Regul 51:84-90. 2011
    ..So are PtdIns3P and PtdIns(3,5)P2, which have ubiquitous roles in the regulation of membrane trafficking events. However, synthesis of and signalling by PtdIns(3,4,5) P 3 appears to be confined to a later-evolved group of eukaryotes...
  73. ncbi Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial
    Enrico Papaleo
    IVF Unit, Gynecologic Obstetric Department, Istituto di Ricovera e Cura a Carattere Scientifico, San Raffaele Hospital, Vita Salute University, Milan, Italy
    Fertil Steril 91:1750-4. 2009
    To determine the effects of myo-inositol on oocyte quality in polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI) cycles.
  74. ncbi Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging
    Finian M O'Brien
    Department of Psychological Medicine, Kings College London, UK
    Psychiatry Res 184:77-85. 2010
    ..1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)...
  75. pmc Myoinositol oxygenase controls the level of myoinositol in Arabidopsis, but does not increase ascorbic acid
    Stefanie Endres
    University of Salzburg, 5020 Salzburg, Austria
    Plant Physiol 149:1042-9. 2009
    ..We conclude that D-GlcUA derived from the Miox reaction plays a negligible role for AsA biosynthesis. However, Miox controls the metabolite level of myoinositol in plants...
  76. ncbi Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis
    K T M Fernando
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 127:1361-9. 2004
    ..total creatine and phosphocreatine (Cr), choline-containing compounds, glutamate plus glutamine, and myo-inositol (Ins) were estimated automatically using the LCModel...
  77. pmc Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins
    D Hamburger
    Biozentrum of the University of Basel, Switzerland
    J Cell Biol 129:629-39. 1995
    ..Therefore, Gaa1p is required for a terminal step of GPI anchor attachment and could be part of the putative GPI:protein transamidase...
  78. ncbi A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity
    Dario Panzeri
    Istituto di Biologia e Biotecnologia Agraria, CNR, Milano, Italy
    New Phytol 191:70-83. 2011
    ..expression level of several genes of the InsP(6) pathway are reduced in the lpa1(280-10) mutant as well as the inositol and raffinosaccharide content. PvMrp2, a very similar paralogue of PvMrp1 was also mapped and sequenced...
  79. ncbi Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae
    Andrew M Seeds
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27654-61. 2005
    The production of inositol polyphosphate (IPs) and pyrophosphates (PP-IPs) from inositol 1,4,5-trisphosphate (I(1,4,5)P3) requires the 6-/3-/5-kinase activity of Ipk2 (also known as Arg82 and inositol polyphosphate multikinase)...
  80. ncbi The biosynthesis of acarbose and validamycin
    T Mahmud
    Department of Chemistry, University of Washington, Seattle, 98195-1700, USA
    Chem Rec 1:300-10. 2001
    ..The stage is now set for unraveling the mechanism or mechanisms by which the two components of the pseudodisaccharide moieties of acarbose and validamycin are uniquely coupled to each other via a nitrogen bridge...
  81. pmc Regulation of phospholipid synthesis in yeast
    George M Carman
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 50:S69-73. 2009
    ..Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression...
  82. pmc Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol
    D W Heinz
    Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
    EMBO J 14:3855-63. 1995
    ..site of the enzyme has been identified by determining the structure of PI-PLC in complex with its inhibitor, myo-inositol, at 2.6 A resolution (R factor = 19.5%)...
  83. pmc Alternative epimerization in C(7)N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of the vicinal oxygen chelate superfamily
    Hui Xu
    Shanghai Jiao Tong University, China
    Chem Biol 16:567-76. 2009
    ..Our data have established ValD as one of the largest proteins of the VOC superfamily, catalyzing an alternative epimerization for C(7)N-aminocyclitol biosynthesis...
  84. pmc Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it
    Todd B Reynolds
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Microbiology 155:1386-96. 2009
    myo-Inositol (inositol) is an essential nutrient that is used for building phosphatidylinositol and its derivatives in eukaryotes and even in some eubacteria such as the mycobacteria...
  85. pmc ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A
    Kazuyuki Minagawa
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331 3507, USA
    Chembiochem 8:632-41. 2007
    ..The results provide new insights into the activity of this enzyme and also confirm the existence of two different pathways leading to the same end-product: the valienamine moiety common to acarbose and validamycin A...
  86. ncbi Gray and white matter brain chemistry in young children with autism
    Seth D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
    Arch Gen Psychiatry 63:786-94. 2006
    ..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
  87. ncbi Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice
    Kristin McLarty
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 38:953-9. 2011
    The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice...
  88. ncbi Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p
    Niketa M Jani
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mol Microbiol 70:1529-39. 2008
    ..g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence...
  89. pmc Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008
    Yi Yu
    Bio X Life Science Research Center, Shanghai Jiaotong University, Shanghai 200030, China
    Appl Environ Microbiol 71:5066-76. 2005
    ..coli. The information obtained should pave the way for further detailed analysis of the complete biosynthetic pathway, which would lead to a complete understanding of validamycin biosynthesis...
  90. pmc Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A
    Linquan Bai
    Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030, China
    Chem Biol 13:387-97. 2006
    ..The role of valG in the glycosylation of validoxylamine to VAL-A was demonstrated in vitro by enzymatic assay...
  91. ncbi A novel salt-tolerant L-myo-inositol-1-phosphate synthase from Porteresia coarctata (Roxb.) Tateoka, a halophytic wild rice: molecular cloning, bacterial overexpression, characterization, and functional introgression into tobacco-conferring salt tolerance
    Manoj Majee
    Plant Molecular and Cellular Genetics, Bose Institute Centenary Building, P 1 12, CIT Scheme VII M, Kolkata 700054, India
    J Biol Chem 279:28539-52. 2004
    l-myo-Inositol-1-phosphate synthase (EC 5.5.1.4, MIPS), an evolutionarily conserved enzyme protein, catalyzes the synthesis of inositol, which is implicated in a number of metabolic reactions in the biological kingdom...
  92. ncbi The cellular language of myo-inositol signaling
    Glenda E Gillaspy
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    New Phytol 192:823-39. 2011
    The simple polyol, myo-inositol, is used as a building block of a cellular language that plays various roles in signal transduction...
  93. ncbi The C7N aminocyclitol family of natural products
    Taifo Mahmud
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Nat Prod Rep 20:137-66. 2003
    ..The literature from 1970 to July 2002 is reviewed, with 269 references cited...
  94. pmc Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    J Autism Dev Disord 39:1079-86. 2009
    ..This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD...
  95. ncbi Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway
    Chang Sheng Zhang
    Institute of Chemical Microbiology Bergische University, Gauss Strasse 20, D 42097 Wuppertal, Germany
    J Biol Chem 277:22853-62. 2002
    ..A biosynthetic pathway for the pseudodisaccharidic acarviosyl moiety of acarbose is proposed on the basis of these data...
  96. pmc Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis
    Lina Zheng
    Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 7:e32033. 2012
    ..Furthermore, the modeling of V7P in the active site of ValL suggests that ValL might have a similar SNi-like mechanism as OtsA...
  97. ncbi Enhanced salt tolerance of transgenic tobacco plants by co-expression of PcINO1 and McIMT1 is accompanied by increased level of myo-inositol and methylated inositol
    Barunava Patra
    Plant Molecular and Cellular Genetics, Bose Institute Centenary Building, P1 12, C I T Scheme VIIM, Kolkata, 700054, India
    Protoplasma 245:143-52. 2010
    Introgression and functional expression of either the PcINO1 (L: -myo-inositol 1-phosphate synthase or MIPS coding gene from the wild halophytic rice, Porteresia coarctata) or McIMTI (inositol methyl transferase, IMTI coding gene from ..
  98. pmc Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling
    Manuel J Villa-García
    Department of Molecular Biology and Genetics, Cornell University, 249 Biotechnology Building, Ithaca, NY 14853, USA
    Mol Genet Genomics 285:125-49. 2011
    b>Inositol auxotrophy (Ino(-) phenotype) in budding yeast has classically been associated with misregulation of INO1 and other genes involved in lipid metabolism...
  99. ncbi Untreated glioblastoma multiforme: increased myo-inositol and glutamine levels in the contralateral cerebral hemisphere at proton MR spectroscopy
    Kai Kallenberg
    MR Research in Neurology and Psychiatry, Department of Neuroradiology, Universitymedicine, Georg August Universitat Gottingen, Robert Koch Strasse 40, 37099 Gottingen, Germany
    Radiology 253:805-12. 2009
    ....
  100. pmc Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis
    C Sutterlin
    Biozentrum of the University of Basel, Switzerland
    EMBO J 16:6374-83. 1997
    ..Consistent with the block in GPI synthesis, YW3548 prevents the incorporation of [3H]myo-inositol into proteins, transport of GPI-anchored proteins to the Golgi and is toxic...
  101. ncbi High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression
    Huirong Zheng
    Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
    Prog Neuropsychopharmacol Biol Psychiatry 34:1189-95. 2010
    ..In this study metabolic changes within PFC of severely depressed patients before and after rTMS were evaluated by proton magnetic resonance spectroscopy (1H-MRS)...

Research Grants75

  1. PTEN TUMOR SUPPRESSOR AND SIGNAL TRANSDUCTION
    RAMON E PARSONS; Fiscal Year: 2012
    ..messenger, phosphatidylinositol-3,4,5-triphosphate (Pl- 3,4,5-P), and removes the 3'-phosphate from the inositol ring. PTEN therefore antagonizes PI-3 kinase, which phosphorylates the inositol ring at the same position...
  2. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..Phospholipase C generates inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors...
  3. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..The ATM gene encodes a large (369 kDa) protein, ATM, which is a member of the phosphatidyl inositol 3 kinase family of serine/threonine protein kinases...
  4. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..niches (pigeon guano, plants/trees) and in response to nutrient limitation, light/darkness, carbon dioxide, and inositol;2) elucidated same-sex genetic cascades involving the novel cell surface receptor Cpr2 and the nuclear ..
  5. GILZ Regulation of ENaC
    David Pearce; Fiscal Year: 2012
    ..These ENaC-regulating GILZ-interacting proteins (GILZIPs) include SGK1 (a phosphatidyl inositol-3-kinase-dependent kinase, which stimulates ENaC), Nedd4-2 (a ubiquitin ligase, which inhibits ENaC), and Raf-1 (..
  6. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..dephosphorylation of the receptor by phosphatases, which are inhibited by over-activation of phosphatidyl inositol 3-kinase (PI3Kg). ?AR numbers are low due to defective intracellular recycling of phosphorylated receptors...
  7. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    ..suggest that SH3BP2 stimulates a phosphatidylinositol-specific phospholipase C (PI-PLC), and the production of inositol phosphate 3 (IP3) leads to release of calcium from the endoplasmic reticulum...
  8. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Similarities include a close primary sequence homology and signaling through the Gq-protein (phospholipaseC/inositol triphosphate) pathway instead of the Gt-protein cyclic nucleotide pathway...
  9. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
    ..Lithium, used for treatment of BD, alters steady-state mRNA levels of a large number of genes;notably GSK-32, inositol monophosphatase (IMPase), MIP Synthase, Bcl-2, Akt, Protein Kinase C, MARCKS, insulin-like growth factor binding ..
  10. ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTOR
    J Kevin Foskett; Fiscal Year: 2013
    ..goal of our proposed studies is to extend our novel insights into biochemical and functional interactions of the inositol trisphosphate receptor (InsP3R) Ca2+ release ion channel and anti-apoptotic Bcl-2 family proteins, and into the ..
  11. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..Thus, while acidic PLs, specifically inositol 4, 5 bisphosphate, is believed to play an important role in vinculin regulation and function, its role remains ..
  12. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2013
    ..mannosyltransferase;MPI, mannosylated phosphatidylinositol;MS, mass spectrometry;myo-Ins, myo-inositol;ORF, open reading frame;investigator, phosphatidyl-myo-inositol;PIM, phosphatidyl-myo-inositol mannosides;TFA, ..
  13. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ..Of the three known Ca2+ mobilization second messengers, inositol 1,4,5-trisphosphate (IP3), cyclic ADP- ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP), ..
  14. Coordination of Pathophysiologic Endothelial Cell Signaling by ROS
    Madesh Muniswamy; Fiscal Year: 2012
    ..project are to examine (Specific Aim 1) how superoxide triggers upstream Ca2+ signaling and selectively activates inositol 1,4,5-trisphosphate receptors (InsP3R) both in vitro and in vivo;(Specific Aim 2) the role of extracellular ..
  15. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
    ..that SH3BP2 stimulates a form of phosphatidylinositol-specific phospholipase C (PI-PLC), and the production of inositol phosphate 3 (IP3) leads to release of calcium (Ca2+) from the endoplasmic reticulum...
  16. Exocytosis and Coupled Endocytosis in Neuroendocrine Cells
    JOHN DAVID CASTLE; Fiscal Year: 2010
    ..with three proteins that function in exocytosis - small G protein Arf6, phospolipase D1 (PLD1), and phosphatidyl inositol 4-phosphate 5-kinase (PIP5K) - and also participates in opening and dilating fusion pores in DCV exocytosis...
  17. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..ROS activation of a redox-sensitive Src, Lyn kinase, which in turn activate the SH2-containing phosphatidyl inositol phosphatase-1 (SHIP-1)...
  18. Inositol Lipid regulation of membrane fusion and fission
    Lois S Weisman; Fiscal Year: 2013
    ..Results of these studies should provide new insights into the roles and regulation of PI3,5P2 and will provide a basis for determining to roles of PI3,5P2 in the nervous system. ..
  19. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..PSDP) inhibition of phospholipase D, identified endogenous PSDP as a directly inhibitor of phosphatidyl inositol 3- kinase in the regulation of cell activation and uncovered polyisoprenyl diphosphate phosphatase 1 (PDP1) as ..
  20. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..We also hypothesize that a combination of folate/myo-inositol (FA/MI) will alleviate these functional abnormalities, and prevent FAS- related CHDs...
  21. MECHANISM OF INOSITOL TRISPHOSPHATE ACTION
    Suresh K Joseph; Fiscal Year: 2010
    ....
  22. Jouberin and Nephrocystin in Joubert Syndrome
    Joseph G Gleeson; Fiscal Year: 2013
    ..functions of these genes in kidney homeostasis, rhodopsin transport, Wnt-, small GTPase-, and phosphatidyl inositol signaling using a combination of mouse modeling, cell biology and biochemical approaches...
  23. GENETIC DISSECTION OF PHOTOTRANSDUCTION
    Baruch Minke; Fiscal Year: 2011
    ..More specifically: (a) Activation by the second messengers Inositol 1,4,5 trisphosphate (InsP3), Diacylglycerol (DAG) and subsequently Polyunsaturated Fatty Acids (PUFA) due to ..
  24. Lipid Signaling During Fertilization
    Bradley J Stith; Fiscal Year: 2010
    ..Surprisingly, only phospholipase C activation (PLC)(which leads to production of inositol 1,4,5- trisphosphate and sn 1,2-DAG, calcium release and protein kinase C activation, has been widely studied...
  25. PHOSPHOINOSITIDE SIGNALING TO AND WITHIN THE NUCLEUS
    Richard A Anderson; Fiscal Year: 2012
    ..cycle, phosphatidylinositol (PI) is sequentially phosphorylated on the fourth and fifth hydroxyl of the myo-inositol ring by PI kinases and then phosphatidylinositol-phosphate kinases (PIPKs), forming phosphatidylinositol-4,5-..
  26. Role of mitochondrial calcium in the pathogenesis of alcoholic liver disease
    Lawrence D Gaspers; Fiscal Year: 2012
    ..Moreover, cells from alcoholic animals had a larger increase in inositol-1,4,5-trisphosphate (InsP3) formation following low hormone stimulation suggesting that chronic alcohol ..
  27. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    Solomon H Snyder; Fiscal Year: 2013
    ..Akt/mTOR signaling is critical for brain function so that our elucidation of its regulation by inositol pyrophosphates may have therapeutic relevance.
  28. Cancer cell signaling through lipids complexed to proteins
    RAYMOND DANIEL BLIND; Fiscal Year: 2013
    ..hypothesize that PIP lipids bound to NR5As (and other nuclear proteins) are directly remodeled by the PI3- kinase inositol polyphosphate multikinase (IPMK) and the PTEN lipid phosphatase in cancer cells...
  29. Effects of short-chain fatty acids on Epstein-Barr virus in B cell lymphoma
    Kelly L Gorres; Fiscal Year: 2013
    ..The effects of SCFAs on the activation PKC signaling will be investigated by studying inositol metabolism, phospholipase C activation, intracellular calcium levels, and kinase activation...
  30. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..e., PI 4-kinase 2, inositol trisphosphate receptors, CREB, neuronal apoptotic inhibitory protein, CaM kinase II, CaM kinase IV, and ..
  31. Cystitis-Induced Plasticity of Micturitin Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2013
    ..TRPV4 and PACAP/PAC1 may represent a novel mechanism by which PACAP/PAC1 signaling activates phospholipase C and inositol triphosphate to sensitize TRPV4-mediated changes in voiding behavior and painful sensation...
  32. INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROL
    Steven S Segal; Fiscal Year: 2013
    ..1 will determine whether release of Ca2+ from internal stores is integral to SCVD by stimulating ryanodine and inositol 1,4,5- trisphosphate (IP3) receptors before and after store depletion...
  33. Determinants of Germinal Center B Cell Differentiation
    Robert C Rickert; Fiscal Year: 2013
    ..Herein we investigate the pivotal roles of SHIP and PTEN inositol phosphatases in regulating the PI3K pathway and its noted impact on late B cell maturation...
  34. PATHOGENESIS OF DIABETIC NEPHROPATHY
    Yashpal S Kanwar; Fiscal Year: 2013
    ..e., myo- inositol oxygenase (MIOX), in tubulo-interstitial pathobiology in the context of diabetic nephropathy (DN)...
  35. Spinocerebellar Ataxia Type 2 Gene and Gene Product
    Stefan M Pulst; Fiscal Year: 2013
    ..We discovered that mutant ATXN2 induced abnormal calcium release from the ER via enhanced interaction with the inositol-triphosphate receptor (ITPR1). Based on these findings, two specific aims are proposed...
  36. Characterization of Burn-Induced Hepatic Apoptosis
    Marc Gerhard Jeschke; Fiscal Year: 2013
    ..Hypothesis 2 is that burn induces hepatic damage by altering the PI3K/Akt and inositol 1, 4, 5,-triphosphate receptor (IP3R) signaling pathways, leading to calcium store depletion, cytochrome c ..
  37. Regulation of vascular inflammation by mitochondrial reactive oxygen species
    Brian J Hawkins; Fiscal Year: 2012
    ..by which endothelial cells (ECs) sense inflammatory signals is by an increase in intracellular calcium (Ca2+) via inositol 1,4,5-trisphosphate receptors (InsP3R) on the endoplasmic reticulum...
  38. Mechanisms for Stem Cell Differentiation into Cardiac Myocytes
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..The [Ca2+]n oscillations are mediated by inositol trisphosphate receptor 1 (the hMSCell nuclear envelope IP3R is IP3R1);the expression of Ca2+- signaling dependent ..
  39. Cellular Responses to DNA Replication Stress
    Marcus Smolka; Fiscal Year: 2013
    ..The phosphatidyl-inositol-3-kinase-like kinase ATR plays pivotal roles in the RC...
  40. Genetic Predisposition & Prevention of Neural Tube Defects (NTDs)
    MARGARET ELIZABETH contact ROSS; Fiscal Year: 2010
    ..Experiments will use FA and inositol supplementation to test whether these agents prevent NTD in Lrp6 null and NTD-prone mice with defined ENU-..
  41. Effects of Dietary Omega-3 Fatty Acids on Akt Signaling in Prostate Cancer
    Yong Q Chen; Fiscal Year: 2013
    ..linked to a saturated fatty acid, the second carbon (sn-2 position) to an ? 6 PUFA, and the last carbon to inositol. We found that DHA can replace the ?6 fatty acid at the sn-2 position of PIPs in cell culture, thereby generating ..
  42. Identification of a Parasite-Specific, Lipid-Metabolic Pathway Essential for Leis
    Kai Zhang; Fiscal Year: 2009
    ..The objective of this application is to determine the molecular mechanism by which the turnover of inositol phosphorylceramide (IPC) contributes to the infectivity of Leishmania parasites...
  43. The role of cAMP signaling changes in alcoholic liver disease
    VICTORIA LYELL PRINCE; Fiscal Year: 2012
    ..for increased calcium mobilization and subsequent increased mitochondrial calcium loading in response to inositol 1,4,5-trisphosphate (IPS) -dependent hormones...
  44. Structural and Signaling Roles for Cardiac Ankyrin-B
    SHANE CUNHA; Fiscal Year: 2013
    ..ANK2 splice variants that remove key exons known to encode binding sites for the sodium/calcium exchanger, inositol (1,4,5) triphosphate receptor, and the large structural and resident M-line protein obscurin...
  45. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2012
    ..receptor densities do not support aromatase expression because they also stimulate the accumulation of inositol phosphates and diacylglycerol leading to the release of epiregulin and phosphorylation of EGFR and ERK1/2...
  46. Inositol Signaling in C. elegans Senescence and Diapause
    GARY B RUVKUN; Fiscal Year: 2013
    ..Variation in both these endocrine systems may underlie human lifespan variation as well as variation in metabolism and drug sensitivities. ..
  47. Ca2+ Waves in Hepatocytes: Mechanisms and Effects
    Michael H Nathanson; Fiscal Year: 2013
    ..In the hepatocyte, Ca2+ signals are mediated entirely by inositol trisphosphate (InsP3), which acts through binding to the InsP3 receptor (InsP3R)...
  48. In Vivo Neuronal Modulation via Engineered G Protein-Coupled Receptors
    SARAH CLAIRE ROGAN; Fiscal Year: 2012
    ..aims, a variety of techniques will be used, including immunohistochemistry, in vivo microdialysis, measurement of inositol phosphate accumulation, immunoblotting, and stereotaxic viral infusion...
  49. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2012
    ..We found that two SH2-containing inositol-5-phosphatases (SHIP1 and SHIP2) regulate glioma cell sensitivity to chemotherapeutics...
  50. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2013
    ..in the Preliminary Studies section that demonstrate the role of adaptor protein 3 (AP-3) complex, phosphatidyl inositol 5 kinase, and Atg5 in intracellular trafficking and signaling by TLRs...
  51. GENETIC REGULATION OF PHOSPHOLIPID SYNTHESIS IN YEAST
    SUSAN ARMSTRONG HENRY; Fiscal Year: 2013
    ..dramatic changes that occur in the synthesis and turnover of phospholipids, sphingolipids and storage lipids when inositol, a precursor of phospholipids in eukaryotes, is added or removed from the growth medium of actively dividing ..
  52. Mood-Stabilizing Medications and the Inositol Signaling System
    Ranga N Parthasarathy; Fiscal Year: 2013
    ..Lithium inhibits brain inositol monophosphatase (IMPase), thereby depleting the available pool of free inositol, and resulting in the correction ..
  53. Mechanisms of Liver Inflammation
    Harmeet Malhi; Fiscal Year: 2013
    ..Therefore, the goals of this proposal are to understand: i) how the Inositol Requiring Protein-1 alpha (IRE1[unreadable])/ X-box binding protein (XBP-1) branch of the UPR increases the ..
  54. HTS for enhancers of neutrophil function that specifically augment PIP3 signal
    Hongbo R Luo; Fiscal Year: 2012
    ..superoxide production, death/survival, and bacteria killing, can be regulated by PtdIns(3,4,5)P3, an inositol phospholipid localized on the plasma membrane...
  55. Calcium Signals Within Membrane Nanotubes
    Ian F Smith; Fiscal Year: 2013
    ..Instead, our observations of local spontaneous and inositol trisphosphate-evoked Ca2+ signals generated within the length of TNTs formed between cultured mammalian cells ..
  56. TARGETING ANTIGEN-INDUCED ER STRESS RESPONSE IN B-CELL CHRONIC LYMPHOCYTIC LEUKEM
    Chih Chi Hu; Fiscal Year: 2013
    ..We have shown that the inositol-requiring enzyme-1 (IRE-1)/X-box- binding protein-1 (XBP-1) pathway of the ER stress response is critical for the ..
  57. Role of p120-catenin in oral squamous cell carcinoma
    Zhongjian Xie; Fiscal Year: 2010
    ..PIP3 in the plasma membrane then recruits and activates PLC-?1, which by hydrolyzing PIP2 to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) causes an increase in intracellular calcium leading to ..
  58. Mechanism of ITAM Signal Regulation in Osteoclasts
    Mary Beth Humphrey; Fiscal Year: 2012
    ..We have found a novel association of activated DAP12 with SH2-containing inositol-5'-phosphatase 1 (SHIP1)...
  59. Acyl-CoA synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
    Paul A Watkins; Fiscal Year: 2013
    ..a relationship between ACSVL3 expression and oncogenic second messenger signaling via the phosphatidyl inositol-3 kinase (PI3K)/Akt and phospholipase c-[unreadable] (PLC-[unreadable])/diacylglycerol (DAG) pathways...
  60. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2012
    ..Patient genotype for the functional polymorphism in inositol 1,4,5-triphosphate 3-kinase C (ITPKC) that affects T-cell activation and for the TNFa -308A allele that affects ..
  61. Role of prostaglandin F2a receptor (FP receptor) in hemorrhagic stroke.
    Shekher Mohan; Fiscal Year: 2013
    ..PGF2[unreadable] when bound to its FP receptors, initiates a signaling cascade that results in the release of inositol-1,4,5-triphosphate and diacylglycerol and in turn activation of the calcium pathway, which has been associated ..
  62. Endoplasmic reticulum stress and intestinal inflammation
    Richard S Blumberg; Fiscal Year: 2013
    ..The most highly conserved pathway is that related to inositol requiring enzyme 1 (IRE1) which, through its endoribonuclease and kinase activities, regulates the ..
  63. GATING AND TRANSLOCATION IN THE DIPHTHERIA TOXIN CHANNEL
    Bruce Kagan; Fiscal Year: 1992
    ..1. Pharmacology of DT gating. The intracellular second messenger 1,4,5-inositol-triphosphate (IP3) bind to DT and stimulates channel formation from the trans side of the membrane...
  64. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..g. 3H-inositol, 14C-arachidonic acid, 32P) to label phospholipids, inositol polyphosphates, arachidonic acid metabolites, and ..
  65. Role of Phospholipase C in Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The long-term goal of our laboratory is to elucidate the role of inositol polyphosphates (InsPs) in transcriptional regulation...
  66. GAMMA GLOBULIN STRUCTURE AND HYPERSENSITIVITY
    Kimishige Ishizaka; Fiscal Year: 1992
    ..IgE antibody molecules by multivalent ligand induced activation of phospholipase C (PLC) for hydrolysis of inositol phospholipids, and that this process may play a major role in the transduction of triggering signals for mediator ..
  67. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2002
    ..neurotransmitters, growth factors, and other stimuli produce their physiological effects by stimulation of inositol lipid breakdown...
  68. Structure-Function Analysis of Leishmania MIT
    Andreas Seyfang; Fiscal Year: 2006
    ..In these protozoan flagellates, myo-inositol plays an especially important role as the precursor for GPI-anchored protective and/or immunomodulatory surface ..
  69. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 1992
    ..While knowledge of the biochemical sequelae resulting from inositol-1,4,5 P3 and diacylglycerol formation has advanced markedly in recent years, the receptor-initiated trans-plasma ..
  70. BRAIN PHOSPHOINOSITIDES AND BARBITURATES
    DIWAKAR DESHMUKH; Fiscal Year: 1993
    ..Among lipophilic drugs, the barbiturates are the nearest in structure to inositol; both contain a six-membered ring with several hydrogen bonding sites (O, OH, or NH groups)...
  71. Coupling of D-chiro-inositol to insulin in PCOS women
    MARIA IUORNO; Fiscal Year: 2004
    ..The cellular mechanisms of insulin resistance in PCOS are still largely unknown. D-chiro-inositol phosphoglycan (DCI-IPG) is a nonclassical mediator of insulin action that has been demonstrated to increase ..
  72. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..volume, cells release Kv, CI-, and "non-perturbing" organic osmolytes, a major component of which is myo-inositol. Efflux of the osmolytes occurs via a volume-sensitive organic anion channel (VSOAC), which primarily gates CI&..
  73. RETINAL MICROVESSELS BASIS FOR INJURY IN DIABETES
    Gary Goldstein; Fiscal Year: 1990
    ..We believe that intracellular sorbitol may interfere with receptor mediated turnover of inositol phospholipids and subsequent activation of protein kinase C and this may, in part, underlie the microangiopathy...
  74. EFFECT OF TSH ON THYROID METABOLISM
    WILLIAM DEERY; Fiscal Year: 1991
    ..Hydrolysis of phosphatidylinositol 4,5 bisphosphate (PIP2) with formation of inositol trisphosphate (IP3) and diacylglycerol is another intracellular signalling system in many tissues...
  75. AGE RELATED CHANGES IN PITUITARY LACTOTROPHS
    Phyllis Callahan; Fiscal Year: 1993
    ..will be on the cell signal transduction mechanism of the lactotroph, specifically the hydrolysis of phosphatidyl-inositol-4,5- bisphosphate (PIP2)...