lysophospholipids

Summary

Summary: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.

Top Publications

  1. ncbi Principles of bioactive lipid signalling: lessons from sphingolipids
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Mol Cell Biol 9:139-50. 2008
  2. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
  3. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
  4. ncbi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
  5. pmc Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    Nitai C Hait
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Science 325:1254-7. 2009
  6. ncbi LPA receptors: subtypes and biological actions
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 50:157-86. 2010
  7. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
  8. pmc GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood
    Tal I Arnon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 333:1898-903. 2011
  9. ncbi Sensing of lysophospholipids by TRPC5 calcium channel
    Philippa K Flemming
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:4977-82. 2006
  10. pmc Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298, USA
    Nature 465:1084-8. 2010

Detail Information

Publications312 found, 100 shown here

  1. ncbi Principles of bioactive lipid signalling: lessons from sphingolipids
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Mol Cell Biol 9:139-50. 2008
    ..Deciphering the mechanisms of these varied cell functions necessitates an understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action...
  2. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
    ..These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement...
  3. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  4. ncbi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
    ..This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer...
  5. pmc Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    Nitai C Hait
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Science 325:1254-7. 2009
    ..Thus, HDACs are direct intracellular targets of S1P and link nuclear S1P to epigenetic regulation of gene expression...
  6. ncbi LPA receptors: subtypes and biological actions
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 50:157-86. 2010
    ....
  7. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
    ..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
  8. pmc GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood
    Tal I Arnon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 333:1898-903. 2011
    ..Moreover, delivery of systemic antigen into follicles is impaired. Thus, GRK2-dependent S1PR1 desensitization allows lymphocytes to escape circulatory fluids and migrate into lymphoid tissues...
  9. ncbi Sensing of lysophospholipids by TRPC5 calcium channel
    Philippa K Flemming
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:4977-82. 2006
    ..We have revealed that one of the TRPC channels, TRPC5, is strongly activated by common endogenous lysophospholipids including lysophosphatidylcholine (LPC) but, by contrast, not arachidonic acid...
  10. pmc Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298, USA
    Nature 465:1084-8. 2010
    ..These results also highlight the key role of SphK1 and its product S1P in TNF-alpha signalling and the canonical NF-kappaB activation pathway important in inflammatory, antiapoptotic and immune processes...
  11. pmc The outs and the ins of sphingosine-1-phosphate in immunity
    Sarah Spiegel
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Nat Rev Immunol 11:403-15. 2011
    ..Finally, we discuss the therapeutic potential of new drugs that target S1P signalling and functions...
  12. ncbi The emerging role of lysophosphatidic acid in cancer
    Gordon B Mills
    MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Cancer 3:582-91. 2003
    ....
  13. pmc Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    J G Garcia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Invest 108:689-701. 2001
    ..Platelet-released Sph-1-P, linked to Rac- and Rho-dependent cytoskeletal rearrangement, may act late in angiogenesis to stabilize newly formed vessels, which often display abnormally increased vascular permeability...
  14. ncbi Endothelial functions of sphingosine-1-phosphate
    Susann Lucke
    Institute of Pathophysiology, Universitatsklinikum Essen, Essen, Germany
    Cell Physiol Biochem 26:87-96. 2010
    ..We will also discuss the potential of interfering with S1P-S1P receptor interactions for the treatment of endothelial disorders and vascular pathologies...
  15. pmc Lysophospholipids and their receptors in the central nervous system
    Ji Woong Choi
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1831:20-32. 2013
    Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied lysophospholipids, are known to influence diverse biological events, including organismal development as well as function and pathogenesis within ..
  16. ncbi Autotaxin and LPA receptor signaling in cancer
    Anna J S Houben
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Metastasis Rev 30:557-65. 2011
    ..In this review, we summarize our present understanding of ATX and LPA receptor signaling in cancer...
  17. pmc An update on sphingosine-1-phosphate and other sphingolipid mediators
    Henrik Fyrst
    Center for Cancer Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Nat Chem Biol 6:489-97. 2010
    ....
  18. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  19. pmc Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
    ..Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development...
  20. ncbi Two pathways for lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aobayama, Aoba ku, Sendai, 980 8578, Japan
    Biochim Biophys Acta 1781:513-8. 2008
    ..One PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a novel LPA receptor called P2Y5...
  21. pmc Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
    Michael Maceyka
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Lipid Res 50:S272-6. 2009
    ....
  22. pmc Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    Makiko Umezu-Goto
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 158:227-33. 2002
    ..It also provides potential novel targets for therapy of pathophysiological states including cancer...
  23. ncbi Regulation and biological activities of the autotaxin-LPA axis
    Laurens A van Meeteren
    Division of Cellular Biochemistry, Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
    Prog Lipid Res 46:145-60. 2007
    ....
  24. ncbi Role of LBPA and Alix in multivesicular liposome formation and endosome organization
    Hirotami Matsuo
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Science 303:531-4. 2004
    ..This process depended on the same pH gradient that exists across endosome membranes in vivo and was selectively controlled by Alix. In turn, Alix regulated the organization of LBPA-containing endosomes in vivo...
  25. ncbi Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells
    Y Yatomi
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Japan
    Blood 96:3431-8. 2000
    ..under alkaline and acidic conditions), capable of detecting Sph-1-P, LPA, and possibly structurally similar lysophospholipids, whereby a marked formation of [(32)P]Sph-1-P, but not [(32)P]LPA, was observed in [(32)P]orthophosphate-..
  26. ncbi Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 112:41-52. 2008
    ..Targeting of the sphingolipid rheostat may thus open new treatment options...
  27. pmc Essential role for sphingosine kinases in neural and vascular development
    Kiyomi Mizugishi
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Mol Cell Biol 25:11113-21. 2005
    ..Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases...
  28. pmc Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    Laurens A van Meeteren
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 26:5015-22. 2006
    ....
  29. ncbi Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
    M J Lee
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington 06030 3501, USA
    Cell 99:301-12. 1999
    ..Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neovessels in vivo. These data define SPP as a novel regulator of angiogenesis...
  30. ncbi Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease
    Katherine J E Sattler
    Institute for Pathophysiology, University Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    Basic Res Cardiol 105:821-32. 2010
    ..The HDL-C-normalized plasma level of S1P is increased in sCAD and even further in MI. This may be caused by an uptake defect of HDL for plasma S1P in CAD, and may represent a novel marker of HDL dysfunction...
  31. pmc Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    R Jasinska
    Department of Biochemistry Signal Transduction Laboratories, Lipid and Lipoprotein Research Group, University of Alberta, 357 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada
    Biochem J 340:677-86. 1999
    ..The product of LPP-1 cDNA is concluded to act partly to degrade exogenous lysophosphatidate and thereby regulate its effects on cell signalling...
  32. ncbi The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  33. ncbi LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells
    Min Chen
    Department of Surgery, University of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77555 0525, USA
    Am J Physiol Cell Physiol 292:C1927-33. 2007
    ..In summary, our results suggest that the expression of both LPA1 and LPA2 may contribute to chemotaxis and may permit cells to respond optimally to a wider range of LPA concentrations, thus revealing a new aspect of LPA signaling...
  34. ncbi Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
    Michael Maceyka
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 E Marshall St, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1585:193-201. 2002
    ..Med. 6 (2000) 1109]. Here we review the growing literature on the regulation of SphK and the role of SphK and its product, S1P, in apoptosis...
  35. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P...
  36. pmc "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
    Kazuaki Takabe
    Department of Surgery, Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Pharmacol Rev 60:181-95. 2008
    ....
  37. ncbi Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
    Kyoko Noguchi
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Core Research for Evolutional Science and Technology CREST of Japan Science and Technology Corporation, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:25600-6. 2003
    ..These facts suggest that p2y9/GPR23 has evolved from different ancestor sequences from the Edg family...
  38. pmc Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
    Thomas M McIntyre
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Proc Natl Acad Sci U S A 100:131-6. 2003
    ..Moreover, LPA produced by stimulated plasma platelets activates PPARgamma in nucleated cells...
  39. ncbi The ins and outs of lysophosphatidic acid signaling
    Wouter H Moolenaar
    Division of Cellular Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    Bioessays 26:870-81. 2004
    ..Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis...
  40. ncbi Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
    Nitai C Hait
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E Marshall St, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1758:2016-26. 2006
    ..Here we review the growing recent literature on the regulation and the roles of SphKs and S1P in apoptosis and diseases...
  41. ncbi Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
    Y Morita
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 6:1109-14. 2000
    ..Thus, the sphingomyelin pathway regulates developmental death of oocytes, and sphingosine-1-phosphate provides a new approach to preserve ovarian function in vivo...
  42. pmc The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
    ..Our studies establish an S1P(1)-mTOR axis that controls T cell lineage specification...
  43. ncbi High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor
    Gregor Theilmeier
    Institute for Anatomy, Department of Anesthesiology and Intensive Care, University Hospital Munster, Vesaliusweg 2 4, 48149 Munster, Germany
    Circulation 114:1403-9. 2006
    ..We hypothesized that some of the cholesterol transport-independent biological properties of high-density lipoprotein (HDL) implied in atheroprotection may also be beneficial in settings of acute myocardial reperfusion injury...
  44. ncbi Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
    Akira Tokumura
    Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770 8505, Japan
    J Biol Chem 277:39436-42. 2002
    ....
  45. ncbi Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins
    R T Windh
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:27351-8. 1999
    ..These studies represent the first characterization of S1P receptor activity through G proteins directly and establish fundamental differences in coupling...
  46. ncbi Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling
    Borhane Annabi
    Laboratoire d Oncologie Moleculaire, Departement de Chimie, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Mol Carcinog 48:910-9. 2009
    ..in response to lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two circulating bioactive lysophospholipids and potent inducers of cancer...
  47. ncbi Sphingosine 1-phosphate, a key cell signaling molecule
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    J Biol Chem 277:25851-4. 2002
  48. ncbi High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors
    Takao Kimura
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    Arterioscler Thromb Vasc Biol 23:1283-8. 2003
    ..However, the cellular mechanism by which HDL exerts antiatherogenic actions is not well understood. In this study, we focus on the lipid components of HDL as mediators of the lipoprotein-induced antiatherogenic actions...
  49. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
    ..These data identify LPA3 receptor-mediated signalling as having an influence on implantation, and further indicate linkage between LPA signalling and prostaglandin biosynthesis...
  50. ncbi Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Thromb Haemost 101:665-73. 2009
    ....
  51. pmc Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking
    Maria L Allende
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:7348-58. 2011
    ..Thus, a genetic block in S1P degradation elicits a pro-inflammatory response but impairs neutrophil migration from blood into tissues...
  52. ncbi Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice
    Hui Li
    Indiana University Purdue University Indianapolis, 975 West Walnut Street, Indianapolis, IN 46202, USA
    Mol Cancer Ther 8:1692-701. 2009
    ..Because ID8 cells respond to LPA similar to human EOC cells, this model is very valuable in developing and testing therapeutic reagents targeting LPA in EOC...
  53. pmc Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6
    Keisuke Yanagida
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Univerfsity of Tokyo, Tokyo, Japan
    J Biol Chem 284:17731-41. 2009
    ..A recent study has suggested that p2y5 is an LPA receptor essential for human hair growth. We confirmed that p2y5 is a functional LPA receptor and propose to designate this receptor LPA6...
  54. ncbi LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4
    Yao Bin Liu
    Tissue Repair, Pfizer, Inc, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 109:794-800. 2010
    ..Consistent with the ability of LPA4 to inhibit osteoblastic differentiation of stem cells, LPA4-deficient mice have increased trabecular bone volume, number, and thickness...
  55. ncbi Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, and Centre National de la Recherche Scientifique, UMR6102, Marseille, France
    Nat Immunol 8:1337-44. 2007
    ..Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P5...
  56. ncbi Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
    Fumikazu Okajima
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Japan
    Biochim Biophys Acta 1582:132-7. 2002
    ..Furthermore, S1P content in LDL was markedly decreased during its oxidation. This paper will discuss whether S1P is an atherogenic mediator or an anti-atherogenic mediator...
  57. ncbi Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 275:28398-405. 2000
    ..These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action...
  58. pmc Role for sphingosine kinase 1 in colon carcinogenesis
    Toshihiko Kawamori
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Ave, Ste 309, Charleston, SC 29425, USA
    FASEB J 23:405-14. 2009
    ..These results are the first in vivo evidence that the SphK1/S1P pathway contributes to colon carcinogenesis and that inhibition of this pathway is a potential target for chemoprevention...
  59. ncbi Sphingosine-1-phosphate in cell growth and cell death
    S Spiegel
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 845:11-8. 1998
    ....
  60. pmc The vascular S1P gradient-cellular sources and biological significance
    Timothy Hla
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06001, USA
    Biochim Biophys Acta 1781:477-82. 2008
    ..From an evolutionary perspective, S1P receptors may have co-evolved with the advent of a closed vascular system and the trafficking paradigms for hematopoietic cells to navigate in and out of the vascular system...
  61. pmc A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility
    Shang Zhong Xu
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Circ Res 98:1381-9. 2006
    ..The extracellular effect appears to have a primary role in S1P-evoked cell motility. The data suggest S1P sensing by TRPC5 calcium channel is a mechanism contributing to vascular smooth muscle adaptation...
  62. ncbi The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
    Christopher M Henstridge
    Centre for Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    FASEB J 23:183-93. 2009
    ..Thus, LPI is a potent and efficacious ligand at GPR55, which is likely to be a key plasma membrane mediator of LPI-mediated signaling events and changes in gene expression...
  63. ncbi Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters
    Ryunosuke Ohkawa
    Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan
    Ann Clin Biochem 45:356-63. 2008
    ..Thus, we attempted to develop a method of measuring the plasma Sph-1-P concentration for use in the clinical laboratory setting...
  64. pmc Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
    Kazuaki Takabe
    From the Division of Surgical Oncology, Massey Cancer Center, Virginia Commonwealth University School ofMedicine, Richmond, Virginia 23298, USA
    J Biol Chem 285:10477-86. 2010
    ....
  65. pmc Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression
    Eunok Im
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Mol Cell Biol 30:2401-10. 2010
    ..These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors...
  66. ncbi Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate
    Constantin Bode
    Institute for Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    J Cell Biochem 109:1232-43. 2010
    ....
  67. ncbi Regulation and functional roles of sphingosine kinases
    Regina Alemany
    Institut fur Pharmakologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:413-28. 2007
    ..In this review, our understanding of structure, regulation, and functional roles of SphKs is updated and discussed with regard to their implication in pathophysiological and disease states...
  68. pmc Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
    Nicole Gellings Lowe
    Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4614, USA
    Cardiovasc Res 82:303-12. 2009
    ..Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, regulates the function of numerous cell types. In this study, we determined the role of S1P in promoting pro-fibrotic actions of cardiac fibroblasts (CFs)...
  69. ncbi The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    Atsuo Kawahara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Science 323:524-7. 2009
    ..Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration...
  70. ncbi Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection
    Katherine Sattler
    Institute of Pathophysiology, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Cardiovasc Res 82:201-11. 2009
    ..Finally, we will elucidate the potential benefits and limitations of S1P analogues as a new class of functional HDL mimetics for cardiovascular therapy...
  71. ncbi Lysophosphatidic acid is a bioactive mediator in ovarian cancer
    Xianjun Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Box 317, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochim Biophys Acta 1582:257-64. 2002
    ..Thus, LPA could be a potential target for cancer therapy. This review summarizes evidence that implicates LPA in the pathophysiology of human ovarian cancer and likely other types of human malignancies...
  72. ncbi Lysophosphatidic acid (LPA) and its receptors
    Kyoko Noguchi
    The Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States
    Curr Opin Pharmacol 9:15-23. 2009
    ..In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors...
  73. pmc TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells
    Andreas Gschwind
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 22:2411-21. 2003
    ..Thus, TACE can function as an effector of GPCR-mediated signalling and represents a key element of the cellular receptor cross-talk network...
  74. ncbi G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
    Julie Radeff-Huang
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA
    J Cell Biochem 92:949-66. 2004
    ....
  75. pmc The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
    Lauren S Whyte
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom
    Proc Natl Acad Sci U S A 106:16511-6. 2009
    ..In addition, this study also brings to light an effect of both the endogenous ligand, LPI, on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover in vivo...
  76. pmc The alliance of sphingosine-1-phosphate and its receptors in immunity
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:753-63. 2008
    ....
  77. ncbi Erythrocytes store and release sphingosine 1-phosphate in blood
    Petra Hänel
    Institute for Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    FASEB J 21:1202-9. 2007
    ..Adoptively transferred S1P-loaded and unloaded mouse erythrocytes displayed a normal life span and similar S1P levels 24 h after recovery, indicating that S1P incorporation and release are dynamically regulated in vivo...
  78. ncbi Point-counterpoint of sphingosine 1-phosphate metabolism
    Julie D Saba
    Children s Hospital of Oakland Research Institute, Oakland, Calif, USA
    Circ Res 94:724-34. 2004
    ....
  79. ncbi International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    Jerold Chun
    Merck Research Laboratories, La Jolla, California 92037, USA
    Pharmacol Rev 54:265-9. 2002
    The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules...
  80. ncbi Sphingosine 1-phosphate analogs as receptor antagonists
    Michael D Davis
    Biochemistry and Molecular Genetics, Pharmacology, and Chemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:9833-41. 2005
    ..These new chemical entities will enable further understanding of S1P signaling and provide leads for further S1P receptor antagonist development...
  81. ncbi Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate
    Miguel A Frias
    Division of Endocrinology, Diabetology and Nutrition, University Hospital, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Cardiovasc Res 82:313-23. 2009
    ..We have investigated modulating the composition of rHDL as a means of expanding its function and potential cardioprotective effects...
  82. pmc Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to
    M Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 24:976-85. 2010
    ..We conclude and propose a new paradigm that S1P is a crucial chemoattractant for BM-residing HSPCs and that CC through MAC induces the release of S1P from erythrocytes for optimal egress/mobilization of HSPCs...
  83. ncbi Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
    J P Hobson
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Science 291:1800-3. 2001
    ..Our results reveal a role for receptor cross-communication in which activation of a GPCR by a receptor tyrosine kinase is critical for cell motility...
  84. ncbi Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models
    Dimitri Pchejetski
    INSERM, U466, Toulouse, France
    Cancer Res 65:11667-75. 2005
    ..SphK1-overexpressing PC-3 cells implanted in animals developed remarkably larger tumors and resistance to docetaxel treatment. These results provide the first in vivo demonstration of SphK1 as a sensor of chemotherapy...
  85. pmc Circulating sphingolipid biomarkers in models of type 1 diabetes
    Todd E Fox
    Department of Pharmacology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
    J Lipid Res 52:509-17. 2011
    ....
  86. pmc Extracellular and intracellular actions of sphingosine-1-phosphate
    GRAHAM M STRUB
    Department of Biochemistry and Molecular Biology, VCU School of Medicine, 1101 E Marshall Street, 2 011 Sanger Hall, Richmond, Virginia 23298, USA
    Adv Exp Med Biol 688:141-55. 2010
    ..This chapter is focused on the current literature on extracellular and intracellular actions of S1P...
  87. pmc Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice
    Myat Lin Oo
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
    J Clin Invest 121:2290-300. 2011
    ....
  88. ncbi Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
    Dagmar Meyer Zu Heringdorf
    Institut für Pharmakologie Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Biochim Biophys Acta 1768:923-40. 2007
    The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse groups of G-protein-coupled receptors that are widely expressed and ..
  89. pmc Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
    Mu En Lin
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Prostaglandins Other Lipid Mediat 91:130-8. 2010
    ..Modulation of LPA signaling may thus provide therapeutic inroads for the treatment of human disease...
  90. pmc Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
    Eric Camerer
    Cardiovascular Research Institute, UCSF, San Francisco, California 94158 2517, USA
    J Clin Invest 119:1871-9. 2009
    ..Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak. This pathway prevents lethal responses to leak-inducing mediators in mouse models...
  91. ncbi Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum
    Y Yatomi
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma gun
    J Biochem 121:969-73. 1997
    ....
  92. ncbi Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Cancer Res 63:1706-11. 2003
    ..Our results suggest that LPA acts as a potent stimulator of colon cancer progression, although the binding to LPA1 and LPA2 induces slightly different responses...
  93. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
    ..Our results demonstrate that apoM, by delivering S1P to the S1P(1) receptor on endothelial cells, is a vasculoprotective constituent of HDL...
  94. pmc Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling
    Jun Du
    Department of Physiology, Nanjing Medical University, Nanjing, China
    PLoS ONE 5:e15940. 2010
    ..However, the underlying signaling mechanisms for LPA-induced motility of cancer cells remain to be elucidated...
  95. ncbi Lysophospholipids are potential biomarkers of ovarian cancer
    Rebecca Sutphen
    Department of Interdisciplinary Oncology, College of Medicine and H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, 33612, USA
    Cancer Epidemiol Biomarkers Prev 13:1185-91. 2004
    To determine whether lysophosphatidic acid (LPA) and other lysophospholipids (LPL) are useful markers for diagnosis and/or prognosis of ovarian cancer in a controlled setting.
  96. ncbi Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
    Timothy Hla
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Cornell University, New York, NY 10065, USA
    Neurology 76:S3-8. 2011
    ..This review highlights the normal physiologic processes modulated by S1P and S1PRs, and the therapeutic effects of S1PR modulation in the immune, central nervous, and cardiovascular systems...
  97. pmc GPR55 ligands promote receptor coupling to multiple signalling pathways
    Christopher M Henstridge
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Pharmacol 160:604-14. 2010
    ....
  98. pmc Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Biochem J 397:461-71. 2006
    ..These results suggest that export of Sphk-1a occurs under physiological conditions and may contribute to the establishment of the vascular S1P gradient...
  99. ncbi Autotaxin--an LPA producing enzyme with diverse functions
    Keita Nakanaga
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aoba, Aramaki, Aoba ku, Sendai, Miyagi 980 8578, Japan
    J Biochem 148:13-24. 2010
    ..The presence of the ATX gene in other model organisms and recently developed ATX inhibitors, both of which will be definitely useful for further functional analysis of ATX, will also be mentioned...
  100. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
  101. pmc HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Clin Invest 113:569-81. 2004
    ..The vasoactive effects of HDL could be mimicked by three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF)...

Research Grants64

  1. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..The lysophospholipids sphingosine- 1-phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive lipids generated via catabolism ..
  2. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in ..
  4. Association of a common variant of the PPAP2B gene with cardiovascular disease.
    Andrew J Morris; Fiscal Year: 2013
    ..The bioactive lysophospholipids, sphingosphine-1-phosphate (S1P) and lysophosphatidic acid (LPA), act on cell surface receptors expressed by ..
  5. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Phospholipids and lysophospholipids are known to act as lipid mitogens that regulate cell proliferation and survival signaling pathways...
  6. Role of Group 1B Phospholipase A2 on Diet-induced Metabolic Diseases
    David Y Hui; Fiscal Year: 2013
    ..Group 1B phospholipase A2 protein (PLA2G1B) that hydrolyzes phospholipids to generate free fatty acids and lysophospholipids (lysoPL) in the digestive tract...
  7. Lipid Tandem Quadrupole Mass Spectrometer
    ROBERT CARL MURPHY; Fiscal Year: 2010
    ..In addition to this, detailed biochemical studies of phospholipid and lysophospholipids can be pursued that will reveal basic biochemical mechanisms of lipid biochemistry not previously considered...
  8. 48th Annual South Eastern Regional Lipid Conference (SERLC) Funding Support
    Carole A Oskeritzian; Fiscal Year: 2013
    ..For example, phospholipases A generate fatty acids (FA) and lysophospholipids. These enzymes initiate production of lipid ligands, including the eicosanoid metabolites of arachidonic ..
  9. THERAPEUTIC APPROACHES FOR NEURODEGENERATION CAUSED BY PLA2G6 MUTATIONS
    Paul T Kotzbauer; Fiscal Year: 2012
    ..Our previous studies indicate that human Pla2g6 hydrolyzes both phospholipids and lysophospholipids to produce free fatty acids, and that disease-associated mutations dramatically impair the catalytic ..
  10. Lysophospholipids in Radiation Induced Signal Transduction in Malignant Gliomas
    Dennis E Hallahan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The goal of this research is to determine the role of Lysophospholipids in the radiation response in malignant gliomas...
  11. Store-Operated Ca entry and iPLA2 in vascular SMC
    Victoria M Bolotina; Fiscal Year: 2012
    ..displacement of inhibitory CaM from iPLA2[unreadable] which leads to its activation and production of lysophospholipids that in turn activate SOC channels...
  12. Lysophospholipid mechanisms in congenital hydrocephalus
    Jerold Chun; Fiscal Year: 2012
    ..This proposal builds upon a recently reported link between a lipid signaling system and FH: lysophospholipids (LPs) that include LPA (lysophosphatidic acid), S1P (sphingosine 1-phosphate), and other related LPs...
  13. GTP IN PHOSPHOLIPASE ACTIVATION AND INSULIN RELEASE
    STEWART METZ; Fiscal Year: 2000
    ..pancreatic islets; furthermore, the phospholipid hydrolysis products which they generate (arachidonic acid, lysophospholipids, and phosphatidic acid) are insulinotropic...
  14. LIPID METABOLISM IN STIMULATED HUMAN PLATELETS
    M Broekman; Fiscal Year: 1991
    ..activity of lysophospholipase(s) in platelets and neutrophils, and how these enzymes may regulate levels of lysophospholipids, which are lytic to cells but can be utilized as substrate for formation of new phospholipids; 3) presence ..
  15. Immortalization of Pregnant Human Myometrial Cells
    MELVYN SOLOFF; Fiscal Year: 2004
    ..Akt phosphorylation in response to insulin treatment, stimulation of myometrial cell growth by lysophospholipids, quantification of oxytocin receptor ligand binding sites and upregulation by lysophosphatidic acid, ..
  16. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Andrew Morris; Fiscal Year: 2004
    ..Phospholipases A generate fatty acids and lysophospholipids. These enzymes initiate production of receptor-active lipids including lysophosphatidic acid and the ..
  17. PLASMALOGEN-SELECTIVE PLA2 ACTIVATION IN ISCHEMIA
    Jane McHowat; Fiscal Year: 1999
    ..formation is also accompanied by accelerated phospholipid catabolism resulting in the accumulation of lysophospholipids in the sarcolemma which directly contributes to arrhythmogenesis. Dr...
  18. MYOCARDIAL ORGANELLE LIPID STRUCTURE AND FUNCTION
    William Weglicki; Fiscal Year: 1980
    ..Chlorpromazine inhibits dramatically the production in vitro of free fatty acids and lysophospholipids by lysosomal lipases...
  19. ANTINEOPLASTIC ALKYLGLYCEROLIPIDS
    CLAUDE PIANTADOSI; Fiscal Year: 1990
    The purpose of this proposal is to synthesize various analogues of alkyl-lysophospholipids (ALPs) to support two previously funded studies on their biochemistry and pharmacology...
  20. Plasmalogen Metabolism by iPLA2 in Ischemic Myocardium
    Jane McHowat; Fiscal Year: 2005
    ..thrombin stimulation of endothelial cells results in the activation of iPLA2 and the release of choline lysophospholipids. If these metabolites gain access to the ventricular myocyte sarcolemma, they may also contribute to ..
  21. Characterization of a Novel Lysophospholipase
    Ying Huang; Fiscal Year: 2003
    Numerous studies have demonstrated that phospholipids and lysophospholipids act as lipid mitogens that affect cell proliferation and survival by altering various cell signaling pathways...
  22. Integrins and the proinflammatory phospholipase A2
    Yoshikazu Takada; Fiscal Year: 2007
    ..g., arachidonic acid) and lysophospholipids, which act as intracellular second messengers or are further metabolized into potent mediators for ..
  23. S1P, Rho and Akt signaling in cardiomyocyte survival
    JOAN BROWN; Fiscal Year: 2009
    ..The ligands for these receptors include the lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid, as well as thrombin, thromboxane A-2 and various ..
  24. Population-Based Analysis of Ovarian Cancer Biomarkers
    Rebecca Sutphen; Fiscal Year: 2009
    ..Our preliminary data suggest that plasma levels of lysophospholipids (LPL) are elevated in ovarian cancer patients, including patients with early stage disease, and thus may be ..
  25. SPLA2 AND SURFACTANT IN ASTHMA
    David Bass; Fiscal Year: 2003
    ..sPLA2-mediated surfactant dysfunction will be the result of multiple mechanisms including: generation of lysophospholipids and unsaturated fatty acids, conversion of large functional surfactant aggregates to small dysfunctional ..
  26. EFFECTS OF ALKYL-LYSOPHOSPHOLIPIDS IN LEUKEMIA
    WILLIAM VOGLER; Fiscal Year: 1993
    ....
  27. Regulation of angiogenesis by lysophospholipids
    CAROL RIVERA LOPEZ; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): The purpose of this research project is to determine the roles of lysophospholipids in the regulation of angiogenesis...
  28. MEDIATORS OF DIFFERENTIATION, GROWTH AND TRANSFORMATION
    EDWARD GOETZL; Fiscal Year: 1999
    ..will cover: 1) the biochemistry of generation and degradation of biologically active eicosanoids and lysophospholipids; 2) new knowledge of receptors, signal transduction pathways and mechanisms of regulation of cellular ..
  29. CENTRAL PROTEIN FACILITY
    M Martinez Carrion; Fiscal Year: 1991
    ..Enzyme semi-synthesis; 6. Variant forms of histones; 7. Lysophospholipids and synaptic membrane function; 8. Protein-DNA interactions in viruses; 9. GABA/benzodiazepine receptors; 10...
  30. Lysophospholipid Modulation-Apoptosis-Murine Macrophages
    Michael Davis; Fiscal Year: 2003
    ..The goal of this study is to determine the initial components involved in the mechanism used by lysophospholipids to mediate the inhibition of apoptosis...
  31. SPHINGOLIPID METABOLITE, SPHINGOSINE 1 PHOSPHATE
    Sarah Spiegel; Fiscal Year: 2002
    ..This proposal provides a new paradigm for dissecting the complex interplay between intra and extracellular actions of sphingosine-1-phosphate. ..
  32. 4000 Q TRAP LC/MS/MS shared mass spectrometer
    Sarah Spiegel; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  33. FASEB Summer Research Conference on Lysophospholipid Mediators in Health & Diseas
    Sarah Spiegel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2008
    ..have both basic and potentially therapeutic relevance to diseases associated with peripheral myelination: lysophospholipids, small signaling lipids that include lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), ..
  35. Sphingosine-1-phosophate signaling in vasculogenesis
    KELLEY ARGRAVES; Fiscal Year: 2009
    ..Characterize the involvement of integrins in S1P-induced angioblast motility, and 3. Determine the significance S1P signaling to adult vasculogenesis mediated by circulating angioblasts. ..
  36. Computational Approach to Ligand Discovery for LPA GPCR and PPAR
    Abby L Parrill; Fiscal Year: 2010
    ..This research can therefore lead to new treatments for cardiovascular disease and cancer. ..
  37. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2010
    ..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
  38. LYSOPHOSPHATIDIC ACID AND THE PROGRESSION OF PROSTATE CA
    Kevin Lynch; Fiscal Year: 2004
    ..Finally they will identify and quantify the species of LPA produced by prostate cancer cells to determine it suitability as a biomarker. ..
  39. Receptor-mediated S1P signaling in the embryonic brain
    Jerold Chun; Fiscal Year: 2010
    ..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
  40. NAVBO Workshop: Biology of Signaling in the Cardiovascular System
    Timothy Hla; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  41. MOLECULAR PHARMACOLOGY OF LYSOPHOSPHATIDIC ACID
    Kevin Lynch; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  42. RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2009
    ..It may also lead to rational approaches, based on LPA receptor modulation, for preventing or treating mental health disorders with developmental etiologies. ..
  43. S1P Receptor subtypes: Regulating lymphocyte trafficking
    Hugh Rosen; Fiscal Year: 2008
    ..These studies will yield an enhanced understanding of the basic mechanisms by which S1P receptor agonism induces clinically useful immunosuppression of potential use in autoimmunity. ..
  44. ROLES FOR LPA SIGNALING IN CEREBRAL CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2005
    ....
  45. Molecular Libraries Screening Centers Network (MLSCN)(RMI)
    Hugh Rosen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  46. EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS
    Jerold Chun; Fiscal Year: 2001
    ..Years 1-5). This information will provide new insights into the mechanisms behind developmental neurological disorders, especially those affecting the normal functions of the cerebral cortex. ..
  47. Functional studies on normal neural aneuploidy
    Jerold Chun; Fiscal Year: 2007
    ..This proposal will provide a framework for, and data towards, understanding the functional importance of neural aneuploidy in the nervous system. ..
  48. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  49. SQUALENE AND OXIDOSQUALENE CYCLASES
    Glenn Prestwich; Fiscal Year: 2002
    ....
  50. ROLE OF MEMBRANES AND MINERALIZATION OF BONES AND TEETH
    Barbara Boyan; Fiscal Year: 2001
    ..This work will have major implications for our understanding of MV and how cells that calcify their matrix are able to regulate these extracellular organelles at distant sites. ..
  51. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  52. LYMPHOCYTE RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDE
    EDWARD GOETZL; Fiscal Year: 2007
    ..abstract_text> ..
  53. Influence of Sex and Gender on Musculoskeletal Health
    Barbara Boyan; Fiscal Year: 2004
    ..Worldwide current and future clinical trials will be discussed. Short papers on the workshop topics, future directions, and scientific updates will be published via Internet and summary papers in peer-reviewed journals. ..
  54. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  55. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..
  56. LYSOLIPID PHOSPHATE REGULATION OF LYMPHOCYTE FUNCTIONS
    EDWARD GOETZL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. Crosslinkable Hydrogels for Tympanic Membrane Repair
    Glenn Prestwich; Fiscal Year: 2004
    ..Third, we will evaluate the biocompability and otocompability of each gel in vivo by evaluating recovery of auditory function and middle ear histology. ..
  58. Thiol-Reactive Crosslinkers for Biomaterials
    Glenn Prestwich; Fiscal Year: 2004
    ..Fourth, these new materials will be evaluated for cytocompatibility and cell growth in vitro with murine fibroblasts. Finally, selected materials will be seeded with fibroblasts and injected into nude mice for in vivo tissue generation. ..
  59. Angiogenesis in the Pulmonary Microvasculature
    Denis English; Fiscal Year: 2007
    ..abstract_text> ..
  60. Phosphoinositide and Inositol Polyphosphate Probes
    Glenn Prestwich; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  61. Lysophospholipid Mediators in Ovarian Cancer
    Andrew Morris; Fiscal Year: 2005
    ..Successful completion of the research will provide the framework and impetus to develop novel effective therapeutics for ovarian cancer. ..
  62. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002
    ..This novel signaling pathway may play a critical role in glucose and hormone stimulated insulin secretion and beta cell function. ..
  63. Sphingolipid modulators of vascular growth & homeostasis
    Timothy Hla; Fiscal Year: 2005
    ..These efforts will critically assess the central hypothesis that SKIEDG signaling system is a major regulator of angiogenesis. ..
  64. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..