lysophospholipids

Summary

Summary: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.

Top Publications

  1. ncbi Principles of bioactive lipid signalling: lessons from sphingolipids
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Mol Cell Biol 9:139-50. 2008
  2. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
  3. ncbi Sensing of lysophospholipids by TRPC5 calcium channel
    Philippa K Flemming
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:4977-82. 2006
  4. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
  5. ncbi An update on sphingosine-1-phosphate and other sphingolipid mediators
    Henrik Fyrst
    Center for Cancer Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Nat Chem Biol 6:489-97. 2010
  6. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
  7. ncbi The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
  8. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
  9. ncbi Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
  10. ncbi Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
    Maria L Allende
    Genetics of Development and Disease Branch, NIDDK and NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:52487-92. 2004

Research Grants

  1. Novel Roles for Lysophospholippids in Eukaryotic Membrane Biogenesis and Turnover
    Dennis R Voelker; Fiscal Year: 2010
  2. Group V sPla2 in Inflammation and Innate Immunity
    Barbara Balestrieri; Fiscal Year: 2007
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Suzanne Scarlata; Fiscal Year: 2007
  4. Newborn Screening for Adrenoleukodystrophy
    Gerald Raymond; Fiscal Year: 2009
  5. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2010
  6. Newborn Screening for Adrenoleukodystrophy
    Gerald V Raymond; Fiscal Year: 2010
  7. Immortalization of Pregnant Human Myometrial Cells
    MELVYN SOLOFF; Fiscal Year: 2004
  8. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
  9. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2010
  10. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009

Detail Information

Publications238 found, 100 shown here

  1. ncbi Principles of bioactive lipid signalling: lessons from sphingolipids
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Mol Cell Biol 9:139-50. 2008
    ..Deciphering the mechanisms of these varied cell functions necessitates an understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action...
  2. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  3. ncbi Sensing of lysophospholipids by TRPC5 calcium channel
    Philippa K Flemming
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:4977-82. 2006
    ..We have revealed that one of the TRPC channels, TRPC5, is strongly activated by common endogenous lysophospholipids including lysophosphatidylcholine (LPC) but, by contrast, not arachidonic acid...
  4. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
    ..These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement...
  5. ncbi An update on sphingosine-1-phosphate and other sphingolipid mediators
    Henrik Fyrst
    Center for Cancer Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Nat Chem Biol 6:489-97. 2010
    ....
  6. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
    ..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
  7. ncbi The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
    ..Our studies establish an S1P(1)-mTOR axis that controls T cell lineage specification...
  8. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  9. ncbi Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
    ..Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development...
  10. ncbi Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
    Maria L Allende
    Genetics of Development and Disease Branch, NIDDK and NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:52487-92. 2004
    ..The results with these Sphk1 null mice reveal that some key physiologic processes that require S1P receptor signaling, such as vascular development and proper lymphocyte distribution, can occur in the absence of SPHK1...
  11. ncbi Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
    Michael Maceyka
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Lipid Res 50:S272-6. 2009
    ....
  12. ncbi Regulation and biological activities of the autotaxin-LPA axis
    Laurens A van Meeteren
    Division of Cellular Biochemistry, Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
    Prog Lipid Res 46:145-60. 2007
    ....
  13. ncbi Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    Makiko Umezu-Goto
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 158:227-33. 2002
    ..It also provides potential novel targets for therapy of pathophysiological states including cancer...
  14. ncbi GPR55 ligands promote receptor coupling to multiple signalling pathways
    Christopher M Henstridge
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Pharmacol 160:604-14. 2010
    ....
  15. ncbi Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    R Jasinska
    Department of Biochemistry Signal Transduction Laboratories, Lipid and Lipoprotein Research Group, University of Alberta, 357 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada
    Biochem J 340:677-86. 1999
    ..The product of LPP-1 cDNA is concluded to act partly to degrade exogenous lysophosphatidate and thereby regulate its effects on cell signalling...
  16. ncbi Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
    Nitai C Hait
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St, Richmond, VA 23298-0614, USA
    Biochim Biophys Acta 1758:2016-26. 2006
    ..Here we review the growing recent literature on the regulation and the roles of SphKs and S1P in apoptosis and diseases...
  17. ncbi The ins and outs of lysophosphatidic acid signaling
    Wouter H Moolenaar
    Division of Cellular Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    Bioessays 26:870-81. 2004
    ..Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis...
  18. ncbi Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
    Y Morita
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 6:1109-14. 2000
    ..Thus, the sphingomyelin pathway regulates developmental death of oocytes, and sphingosine-1-phosphate provides a new approach to preserve ovarian function in vivo...
  19. ncbi Essential role for sphingosine kinases in neural and vascular development
    Kiyomi Mizugishi
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Mol Cell Biol 25:11113-21. 2005
    ..Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases...
  20. ncbi LPA receptors: subtypes and biological actions
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 50:157-86. 2010
    ....
  21. ncbi Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P...
  22. ncbi The vascular S1P gradient-cellular sources and biological significance
    Timothy Hla
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06001, USA
    Biochim Biophys Acta 1781:477-82. 2008
    ..From an evolutionary perspective, S1P receptors may have co-evolved with the advent of a closed vascular system and the trafficking paradigms for hematopoietic cells to navigate in and out of the vascular system...
  23. ncbi Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    Nitai C Hait
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Science 325:1254-7. 2009
    ..Thus, HDACs are direct intracellular targets of S1P and link nuclear S1P to epigenetic regulation of gene expression...
  24. ncbi Sphingosine-1-phosphate in cell growth and cell death
    S Spiegel
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 845:11-8. 1998
    ....
  25. ncbi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
    ..This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer...
  26. ncbi A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility
    Shang-Zhong Xu
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Circ Res 98:1381-9. 2006
    ..The extracellular effect appears to have a primary role in S1P-evoked cell motility. The data suggest S1P sensing by TRPC5 calcium channel is a mechanism contributing to vascular smooth muscle adaptation...
  27. ncbi The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
    Christopher M Henstridge
    Centre for Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    FASEB J 23:183-93. 2009
    ..Thus, LPI is a potent and efficacious ligand at GPR55, which is likely to be a key plasma membrane mediator of LPI-mediated signaling events and changes in gene expression...
  28. ncbi Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
    Kazuaki Takabe
    From the Division of Surgical Oncology, Massey Cancer Center, Virginia Commonwealth University School ofMedicine, Richmond, Virginia 23298, USA
    J Biol Chem 285:10477-86. 2010
    ....
  29. ncbi Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression
    Eunok Im
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Mol Cell Biol 30:2401-10. 2010
    ..These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors...
  30. ncbi Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters
    Ryunosuke Ohkawa
    Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan
    Ann Clin Biochem 45:356-63. 2008
    ..Thus, we attempted to develop a method of measuring the plasma Sph-1-P concentration for use in the clinical laboratory setting...
  31. ncbi Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298, USA
    Nature 465:1084-8. 2010
    ..These results also highlight the key role of SphK1 and its product S1P in TNF-alpha signalling and the canonical NF-kappaB activation pathway important in inflammatory, antiapoptotic and immune processes...
  32. ncbi Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
    Nicole Gellings Lowe
    Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4614, USA
    Cardiovasc Res 82:303-12. 2009
    ..Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, regulates the function of numerous cell types. In this study, we determined the role of S1P in promoting pro-fibrotic actions of cardiac fibroblasts (CFs)...
  33. ncbi Regulation and functional roles of sphingosine kinases
    Regina Alemany
    Institut fur Pharmakologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:413-28. 2007
    ..In this review, our understanding of structure, regulation, and functional roles of SphKs is updated and discussed with regard to their implication in pathophysiological and disease states...
  34. ncbi Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate
    Constantin Bode
    Institute for Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    J Cell Biochem 109:1232-43. 2010
    ....
  35. ncbi Two pathways for lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aobayama, Aoba ku, Sendai, 980 8578, Japan
    Biochim Biophys Acta 1781:513-8. 2008
    ..One PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a novel LPA receptor called P2Y5...
  36. ncbi Erythrocytes store and release sphingosine 1-phosphate in blood
    Petra Hänel
    Institute for Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    FASEB J 21:1202-9. 2007
    ..Adoptively transferred S1P-loaded and unloaded mouse erythrocytes displayed a normal life span and similar S1P levels 24 h after recovery, indicating that S1P incorporation and release are dynamically regulated in vivo...
  37. ncbi Point-counterpoint of sphingosine 1-phosphate metabolism
    Julie D Saba
    Children s Hospital of Oakland Research Institute, Oakland, Calif, USA
    Circ Res 94:724-34. 2004
    ....
  38. ncbi Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    Laurens A van Meeteren
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 26:5015-22. 2006
    ....
  39. ncbi The alliance of sphingosine-1-phosphate and its receptors in immunity
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:753-63. 2008
    ....
  40. ncbi The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  41. ncbi Sphingosine 1-phosphate analogs as receptor antagonists
    Michael D Davis
    Biochemistry and Molecular Genetics, Pharmacology, and Chemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:9833-41. 2005
    ..These new chemical entities will enable further understanding of S1P signaling and provide leads for further S1P receptor antagonist development...
  42. ncbi International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    Jerold Chun
    Merck Research Laboratories, La Jolla, California 92037, USA
    Pharmacol Rev 54:265-9. 2002
    The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules...
  43. ncbi Sphingosine 1-phosphate signalling in mammalian cells
    S Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK
    Biochem J 349:385-402. 2000
    ..This article describes where the research field is in relation to achieving this aim...
  44. ncbi Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
    Poulami Mitra
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 103:16394-9. 2006
    ..Transport of S1P by ABCC1 influenced migration of mast cells toward antigen but not degranulation. These findings have important implications for S1P functions in mast cell-mediated immune responses...
  45. ncbi Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
    M J Lee
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington 06030 3501, USA
    Cell 99:301-12. 1999
    ..Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neovessels in vivo. These data define SPP as a novel regulator of angiogenesis...
  46. ncbi Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay
    Hong Yin
    GPCR Platform, Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    J Biol Chem 284:12328-38. 2009
    ..The anti-inflammatory effect of 3,3'-diindolylmethane in RAW264.7 cells was shown to be partially mediated by CB(2)...
  47. ncbi Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    J G Garcia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Invest 108:689-701. 2001
    ..Platelet-released Sph-1-P, linked to Rac- and Rho-dependent cytoskeletal rearrangement, may act late in angiogenesis to stabilize newly formed vessels, which often display abnormally increased vascular permeability...
  48. ncbi A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid
    Hirofumi Sonoda
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:34254-63. 2002
    ..In the latter condition, an increased level of LPA, but not other lysophospholipids, was confirmed by mass spectrometry analyses...
  49. ncbi The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    Atsuo Kawahara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Science 323:524-7. 2009
    ..Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration...
  50. ncbi Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    Trung H M Pham
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:17-27. 2010
    ..Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P required for lymphocyte egress from LNs and Peyer's patches, and suggest a role for S1P in lymphatic vessel maturation...
  51. ncbi Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
    Yutong Zhao
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 282:14165-77. 2007
    ..This involves the conversion of extracellular S1P to Sph by LPP-1, which facilitates Sph uptake, followed by the intracellular conversion of Sph to S1P by SphK1...
  52. ncbi Physiological and pathological actions of sphingosine 1-phosphate
    Timothy Hla
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Semin Cell Dev Biol 15:513-20. 2004
    ....
  53. ncbi Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist
    Makoto Osada
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
    Biochem Biophys Res Commun 299:483-7. 2002
    ....
  54. ncbi "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
    Kazuaki Takabe
    Department of Surgery, Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Pharmacol Rev 60:181-95. 2008
    ....
  55. ncbi S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart
    Padmavathi Bandhuvula
    Children s Hospital Oakland Research Institute, Oakland, CA 94609 1673, USA
    Am J Physiol Heart Circ Physiol 300:H1753-61. 2011
    ..These results reveal, for the first time, that SPL is an ischemia-induced enzyme that can be targeted as a novel strategy for preventing cardiac I/R injury...
  56. ncbi Differential changes in GPR55 during microglial cell activation
    Maciej Pietr
    Neurobiology Department, Weizmann Institute of Science, Rehovot 76100, Israel
    FEBS Lett 583:2071-6. 2009
    ....
  57. ncbi Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival
    C Jaillard
    Biologie des Interactions Neurones Glie, Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie, Unité Mixte de Recherche 711, Hopital de la Salpetriere, F 75651 Paris, France
    J Neurosci 25:1459-69. 2005
    ....
  58. ncbi Role for sphingosine kinase 1 in colon carcinogenesis
    Toshihiko Kawamori
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Ave, Ste 309, Charleston, SC 29425, USA
    FASEB J 23:405-14. 2009
    ..These results are the first in vivo evidence that the SphK1/S1P pathway contributes to colon carcinogenesis and that inhibition of this pathway is a potential target for chemoprevention...
  59. ncbi Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes
    Naoki Kobayashi
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    J Biol Chem 284:21192-200. 2009
    ..These results suggest that S1P is exported from the erythrocytes by a novel ATP-dependent transporter...
  60. ncbi Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to
    M Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 24:976-85. 2010
    ..We conclude and propose a new paradigm that S1P is a crucial chemoattractant for BM-residing HSPCs and that CC through MAC induces the release of S1P from erythrocytes for optimal egress/mobilization of HSPCs...
  61. ncbi Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells
    Alayna Rodgers
    Cell Biology Group, SIPBS, University of Strathclyde, Glasgow G4 0NR, United Kingdom
    Stem Cells Dev 18:1319-30. 2009
    ....
  62. ncbi Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine
    Denise G Hemmings
    Department Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, 227 Heritage Medical Research Center, T6G 2S2, Edmonton, Alberta, Canada
    Naunyn Schmiedebergs Arch Pharmacol 373:18-29. 2006
    ..Given this background, recent studies examining a potential role for S1P and SPC in hypertension and vascular dysfunction in aging are discussed...
  63. ncbi Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
    Michael Maceyka
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 E. Marshall St, Richmond, VA 23298-0614, USA
    Biochim Biophys Acta 1585:193-201. 2002
    ..Med. 6 (2000) 1109]. Here we review the growing literature on the regulation of SphK and the role of SphK and its product, S1P, in apoptosis...
  64. ncbi Lysophospholipids and the cardiovascular system
    Joel S Karliner
    VA Medical Center 111C, University of California, 4150 Clement St, San Francisco, CA 94121, USA
    Biochim Biophys Acta 1582:216-21. 2002
    The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis...
  65. ncbi Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway
    Q Zhang
    Departments of Medicine and Biomolecular Chemistry, University of Wisconsin Madison, Madison, WI, USA
    Blood 93:2984-90. 1999
    ..These results indicate a common signal pathway leading to control of cellular fibronectin matrix assembly by bioactive lipids generated during blood coagulation...
  66. ncbi Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype
    Brian R Wamhoff
    Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22901, USA
    Arterioscler Thromb Vasc Biol 28:1454-61. 2008
    ..The role of sphingosine-1-phosphate (S1P) receptors in acute vascular injury and smooth muscle cell (SMC) phenotypic modulation is not completely resolved...
  67. ncbi Deafness and stria vascularis defects in S1P2 receptor-null mice
    Mari Kono
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1821, USA
    J Biol Chem 282:10690-6. 2007
    ..Vascular disturbance within the stria vascularis is a potential mechanism that leads to deafness in the S1P(2) receptor-null mice...
  68. ncbi Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation
    Harald M H G Albers
    Division of Cell Biology, Netherlands Proteomics Centre, Centre of Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 107:7257-62. 2010
    ..Thus, boronic acid-based small molecules hold promise as candidate drugs to target ATX...
  69. ncbi Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation
    Stephanie Langlois
    Laboratoire de Médecine Moléculaire Ste Justine Université du Québec à Montréal, Centre de cancérologie Charles Bruneau, Hôpital Ste Justine et Université du Québec à Montréal, Montreal, QC, Canada
    Blood 103:3020-8. 2004
    ..Given the important contribution of platelets to tumor angiogenesis, the stimulation of endothelial MT1-MMP function by S1P may thus constitute an important molecular event linking hemostasis to angiogenesis...
  70. ncbi GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells
    Alexander Bondarenko
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    Br J Pharmacol 161:308-20. 2010
    ..To estimate the contribution of GPR55 to the physiological effects of LPI, the GPR55-dependent and -independent electrical responses in this cell type were investigated...
  71. ncbi Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses
    Cuiyan Xin
    Pharmazentrum Frankfurt, , Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
    J Biol Chem 279:35255-62. 2004
    ....
  72. ncbi Regulation of vascular permeability by sphingosine 1-phosphate
    Lichun Wang
    Section of Pulmonary and Critical Care Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Microvasc Res 77:39-45. 2009
    ....
  73. ncbi Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology
    Thomas Kirkegaard
    Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 463:549-53. 2010
    ..Taken together, these data open exciting possibilities for the development of new treatments for lysosomal storage disorders and cancer with compounds that enter the lysosomal lumen by the endocytic delivery pathway...
  74. ncbi Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2
    Tsukasa Ohmori
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Japan
    Cardiovasc Res 58:170-7. 2003
    ..CONCLUSIONS: Sph-1-P, derived from platelets and dephosphorylated on the cell surface, may induce the contraction of coronary artery smooth muscle cells through the S1P(2)/Rho signaling...
  75. ncbi Biological roles of lysophospholipid receptors revealed by genetic null mice: an update
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Rd, ICND 118, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1781:531-9. 2008
    Two lysophospholipids (LPs), lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are known to affect various cellular events...
  76. ncbi Deregulation of sphingolipid metabolism in Alzheimer's disease
    Xingxuan He
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 31:398-408. 2010
    ..The reduced levels of S1P in the AD brain, together with elevated ceramide, likely contribute to the disease pathogenesis...
  77. ncbi Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
    Dai Shida
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0614, USA
    Cancer Res 68:6569-77. 2008
    ....
  78. ncbi Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid
    Yasuhiro Kishi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033
    J Biol Chem 281:17492-500. 2006
    ....
  79. ncbi Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    Suzanne Mandala
    Department of Immunology and Rheumatology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA
    Science 296:346-9. 2002
    ..Inhibition of lymphocyte recirculation by activation of S1P receptors may result in therapeutically useful immunosuppression...
  80. ncbi Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways
    S Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, U S A
    Biochem Soc Trans 31:1216-9. 2003
    ..However, S1P also may have intracellular functions. In this review, we discuss two examples that clearly indicate that intracellularly generated and exogenous S1P can regulate biological processes by divergent pathways...
  81. ncbi G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn 53111, Germany
    Nat Genet 40:329-34. 2008
    ..This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans...
  82. ncbi Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    Barbara Visentin
    Department of Biology, San Diego State University, San Diego, California 92182, USA
    Cancer Cell 9:225-38. 2006
    ..The anti-S1P mAb also neutralized S1P-induced proliferation, release of proangiogenic cytokines, and the ability of S1P to protect tumor cells from apoptosis in several tumor cell lines, validating S1P as a target for therapy...
  83. ncbi Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages
    Samar M Hammad
    Medical University of South Carolina, Department of Cell Biology and Anatomy, Charleston, SC 29403, United States
    Prostaglandins Other Lipid Mediat 85:107-14. 2008
    ..Moreover, knockdown of SK1 enhances both TNF- and LPS-induced apoptosis. These data indicate that there is a dual and distinct role for SK1 and S1P in the TNF and the LPS inflammatory pathways...
  84. ncbi Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors
    Terumasa Hashimoto
    Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Pharmacol Sci 100:82-7. 2006
    ..Moreover, these findings point to a role of LPA in the pathomechanisms of various allergic disorders...
  85. ncbi The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+ -activated large-conductance K+ channels in endothelial cells
    Alexander I Bondarenko
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 III, Graz, Austria
    Pflugers Arch 461:177-89. 2011
    b>Lysophospholipids are known to serve as intra- and extracellular messengers affecting many physiological processes...
  86. ncbi Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
    Andreas Weigert
    Institute of Biochemistry I Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit ZAFES, Goethe University Frankfurt, Frankfurt, Germany
    Blood 115:3531-40. 2010
    ..Our data link signaling events during apoptosis to the extracellular production of a lipid mediator that affects immune cell attraction and activation...
  87. ncbi Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response
    George Boguslawski
    Experimental Cell Research Laboratory, Methodist Research Institute, Indianapolis, Indiana 46202, USA
    Exp Cell Res 274:264-74. 2002
    ..SPP and related lipids may play a key role in angiogenesis by coordinating the migration of both endothelial cells and vascular smooth muscle cells in response to the changing gradients of these bioactive lipid messengers...
  88. ncbi Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3
    I Ishii
    Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 276:33697-704. 2001
    ..These results indicate a nonessential role for LP(B3) in normal development of mouse but show nonredundant cellular signaling mediated by a single type of S1P receptor...
  89. ncbi Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
    Norbert F Voelkel
    Department of Biochemistry and Molecular Biology, Victorial Johnson Center for Obstructive Pulmonary Disease Research, Virginia Commonwealth University, Richmond, 23298, USA
    Immunol Cell Biol 87:601-5. 2009
    ....
  90. ncbi Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
    Eric Camerer
    Cardiovascular Research Institute, UCSF, San Francisco, California 94158 2517, USA
    J Clin Invest 119:1871-9. 2009
    ..Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak. This pathway prevents lethal responses to leak-inducing mediators in mouse models...
  91. ncbi Autocrine and paracrine roles of sphingosine-1-phosphate
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Trends Endocrinol Metab 18:300-7. 2007
    ..This review summarizes recent findings on the roles of S1P as a mediator of the actions of cytokines, growth factors and hormones...
  92. ncbi Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator
    Junsuke Igarashi
    Dept of Cardiovascular Physiology, Kagawa Univ Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793 Japan
    Am J Physiol Cell Physiol 292:C740-8. 2007
    ..These results may identify potentially important points of cross-talk between reactive oxygen species and sphingolipid pathways in vascular responses...
  93. ncbi High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function
    Kelley M Argraves
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:25074-81. 2008
    ..Together, the findings indicate that HDL has endothelial barrier promoting activities, which are attributable to its S1P component and signaling through the S1P1/Akt pathway...
  94. ncbi TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells
    Mehmet A Eskan
    Center for Oral Health and Systemic Disease, University of Louisville School of Dentistry, University of Louisville, Louisville, KY 40202, USA
    Eur J Immunol 38:1138-47. 2008
    ..This cooperation between TLR4 and S1P1 or S1P3 demonstrates that TLR4 and GPCR can interact to enhance cytokine production in epithelial cells...
  95. ncbi S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells
    Kyoung Sun Park
    Department of Biochemistry, College of Medicine, Dong A University, Busan 602 714, Republic of Korea
    Biochem Biophys Res Commun 356:239-44. 2007
    ..Taken together, this study suggests that S1P stimulate chemotactic migration and cellular invasion, and VPC 23019-sensitive S1P receptor(s) might be involved in the processes...
  96. ncbi Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness
    Nicholas Young
    Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Exp Cell Res 313:1615-27. 2007
    ..Thus, while S1P(2) decreases glioma cell motility, it may enhance invasion through induction of proteins that modulate glioma cell interaction with the extracellular matrix...
  97. ncbi Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype
    Melanie Schüppel
    Institute of Pharmacy, Pharmacology and Toxicology, Freie Universitat Berlin, Berlin, Germany
    J Invest Dermatol 128:1747-56. 2008
    ..This is of great clinical interest, as the immunomodulator FTY720, after being phosphorylated by sphingosine kinase, activates all of the five S1P receptors except S1P(2) and therefore fails to inhibit keratinocyte proliferation...
  98. ncbi G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase
    Shin Ichiro Takashima
    Department of Physiology, Graduate School of Medical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Cardiovasc Res 79:689-97. 2008
    ..We explored the heterotrimeric G protein and the downstream mechanism that mediated S1P inhibition of Rac and cell migration in VSMCs...
  99. ncbi Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    Arterioscler Thromb Vasc Biol 27:1312-8. 2007
    ..However, cellular consequences of S1P2R signaling in the vascular cells are not well understood...
  100. ncbi Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids
    Guijun Yan
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, MGB G 653, Newark, NJ 07103, USA
    Cardiovasc Res 78:308-14. 2008
    ..Because sphingosine kinase (SK) and its product S1P play essential roles in cell growth, survival and migration, we hypothesized that SK activation by EETs may mediate some of its angiogenic effects...
  101. ncbi Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation
    Eliza Roztocil
    Vascular Biology and Therapeutics Program, Department of Surgery, University of Rochester, Rochester, NY 14642, USA
    J Vasc Surg 46:1253-1259. 2007
    ..The role of phospholipase C (PLC) in oxygen free radical generation, and the regulation of VSMC migration in response to S-1-P, are poorly understood...

Research Grants80

  1. Novel Roles for Lysophospholippids in Eukaryotic Membrane Biogenesis and Turnover
    Dennis R Voelker; Fiscal Year: 2010
    b>Lysophospholipids constitute a class of membrane glycerophospholipids that are rapidly transported and metabolized by many eukaryotic cells ranging from yeast to humans...
  2. Group V sPla2 in Inflammation and Innate Immunity
    Barbara Balestrieri; Fiscal Year: 2007
    ..A2 are a family of enzymes that hydrolyze membrane phospholipids to generate free fatty acids and lysophospholipids. They are involved in a wide range of processes such as inflammation, phospholipid remodeling, cell ..
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Suzanne Scarlata; Fiscal Year: 2007
    ..Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in ..
  4. Newborn Screening for Adrenoleukodystrophy
    Gerald Raymond; Fiscal Year: 2009
    ..we have recently developed a tandem mass spectrometry methodology that can detect altered elevations in lysophospholipids. This methodology is adaptable to regional newborn screening of metabolic disorders offering early diagnosis ..
  5. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2010
    Phospholipids and lysophospholipids are known to act as lipid mitogens that regulate cell proliferation and survival signaling pathways...
  6. Newborn Screening for Adrenoleukodystrophy
    Gerald V Raymond; Fiscal Year: 2010
    ..we have recently developed a tandem mass spectrometry methodology that can detect altered elevations in lysophospholipids. This methodology is adaptable to regional newborn screening of metabolic disorders offering early diagnosis ..
  7. Immortalization of Pregnant Human Myometrial Cells
    MELVYN SOLOFF; Fiscal Year: 2004
    ..Akt phosphorylation in response to insulin treatment, stimulation of myometrial cell growth by lysophospholipids, quantification of oxytocin receptor ligand binding sites and upregulation by lysophosphatidic acid, ..
  8. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
    ..Contractile agonists (lysophospholipids and thrombin), TGF beta, extracellular matrix (ECM) proteins and increased intraocular pressure, all ..
  9. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2010
    ..Contractile agonists (lysophospholipids and thrombin), TGF beta, extracellular matrix (ECM) proteins and increased intraocular pressure, all ..
  10. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
    ..Contractile agonists (lysophospholipids and thrombin), TGF beta, extracellular matrix (ECM) proteins and increased intraocular pressure, all ..
  11. LPA and Edg Receptors in the Pulmonary Immune Respose
    Steve Georas; Fiscal Year: 2007
    The enzymatic metabolism of membrane glycerophospholipids generates bioactive lysophospholipids including lysophosphatidic acid (LPA)...
  12. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Andrew Morris; Fiscal Year: 2004
    ..Phospholipases A generate fatty acids and lysophospholipids. These enzymes initiate production of receptor-active lipids including lysophosphatidic acid and the ..
  13. Rho and G12 in thrombin and lysophospholipid signaling
    JOAN BROWN; Fiscal Year: 2007
    A subset of G-protein coupled receptors, including those for thrombin and the lysophospholipids S1P and LPA, have a remarkable capacity to promote DNA synthesis and actin cytoskeletal rearrangement in mammalian cells...
  14. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2007
    ..have both basic and potentially therapeutic relevance to diseases associated with peripheral myelination: lysophospholipids, small signaling lipids that include lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), ..
  15. LIPID MEDIATORS OF SIGNAL TRANSDUCTION IN SMOOTH MUSCLE
    Richard Gross; Fiscal Year: 1992
    ..g lysophospholipids, phosphatidic acid, free fatty acids and diglycerides)...
  16. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  17. Non-COX Arachidonic Acid Metabolites and Angiogenesis
    GADIPARTHI RAO; Fiscal Year: 2007
    ..Phospholipase A2s (PLA2s), a group of enzymes that breakdown phospholipids generating arachidonic acid and lysophospholipids have been implicated in inflammation...
  18. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY MUSLIN; Fiscal Year: 2009
    ..expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  19. EICOSANOIDS, ANGIOGENESIS, AND RETINOPATHY
    GADIPARTHI RAO; Fiscal Year: 2007
    ..Phospholipase A2s (PLA2s), a group of enzymes that break down phospholipids generating arachidonic acid and lysophospholipids have been implicated in inflammation...
  20. Characterization of a Novel Lysophospholipase
    Ying Huang; Fiscal Year: 2003
    Numerous studies have demonstrated that phospholipids and lysophospholipids act as lipid mitogens that affect cell proliferation and survival by altering various cell signaling pathways...
  21. EICOSANOIDS, ANGIOGENESIS, AND RETINOPATHY
    GADIPARTHI RAO; Fiscal Year: 2006
    ..Phospholipase A2s (PLA2s), a group of enzymes that break down phospholipids generating arachidonic acid and lysophospholipids have been implicated in inflammation...