lysophospholipids

Summary

Summary: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.

Top Publications

  1. doi Principles of bioactive lipid signalling: lessons from sphingolipids
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Mol Cell Biol 9:139-50. 2008
  2. doi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
  3. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
  4. doi LPA receptors: subtypes and biological actions
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 50:157-86. 2010
  5. pmc Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    Nitai C Hait
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Science 325:1254-7. 2009
  6. pmc Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    J G Garcia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Invest 108:689-701. 2001
  7. ncbi Sensing of lysophospholipids by TRPC5 calcium channel
    Philippa K Flemming
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:4977-82. 2006
  8. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
  9. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
  10. pmc The outs and the ins of sphingosine-1-phosphate in immunity
    Sarah Spiegel
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Nat Rev Immunol 11:403-15. 2011

Detail Information

Publications283 found, 100 shown here

  1. doi Principles of bioactive lipid signalling: lessons from sphingolipids
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Mol Cell Biol 9:139-50. 2008
    ..Deciphering the mechanisms of these varied cell functions necessitates an understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action...
  2. doi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
    ..This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer...
  3. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
    ..These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement...
  4. doi LPA receptors: subtypes and biological actions
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 50:157-86. 2010
    ....
  5. pmc Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    Nitai C Hait
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Science 325:1254-7. 2009
    ..Thus, HDACs are direct intracellular targets of S1P and link nuclear S1P to epigenetic regulation of gene expression...
  6. pmc Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    J G Garcia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Invest 108:689-701. 2001
    ..Platelet-released Sph-1-P, linked to Rac- and Rho-dependent cytoskeletal rearrangement, may act late in angiogenesis to stabilize newly formed vessels, which often display abnormally increased vascular permeability...
  7. ncbi Sensing of lysophospholipids by TRPC5 calcium channel
    Philippa K Flemming
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:4977-82. 2006
    ..We have revealed that one of the TRPC channels, TRPC5, is strongly activated by common endogenous lysophospholipids including lysophosphatidylcholine (LPC) but, by contrast, not arachidonic acid...
  8. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
    ..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
  9. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  10. pmc The outs and the ins of sphingosine-1-phosphate in immunity
    Sarah Spiegel
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Nat Rev Immunol 11:403-15. 2011
    ..Finally, we discuss the therapeutic potential of new drugs that target S1P signalling and functions...
  11. pmc "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
    Kazuaki Takabe
    Department of Surgery, Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Pharmacol Rev 60:181-95. 2008
    ....
  12. pmc An update on sphingosine-1-phosphate and other sphingolipid mediators
    Henrik Fyrst
    Center for Cancer Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Nat Chem Biol 6:489-97. 2010
    ....
  13. pmc Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
    Mu En Lin
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Prostaglandins Other Lipid Mediat 91:130-8. 2010
    ..Modulation of LPA signaling may thus provide therapeutic inroads for the treatment of human disease...
  14. ncbi Regulation and biological activities of the autotaxin-LPA axis
    Laurens A van Meeteren
    Division of Cellular Biochemistry, Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
    Prog Lipid Res 46:145-60. 2007
    ....
  15. pmc Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
    Michael Maceyka
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Lipid Res 50:S272-6. 2009
    ....
  16. pmc Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    Makiko Umezu-Goto
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 158:227-33. 2002
    ..It also provides potential novel targets for therapy of pathophysiological states including cancer...
  17. pmc Circulating sphingolipid biomarkers in models of type 1 diabetes
    Todd E Fox
    Department of Pharmacology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
    J Lipid Res 52:509-17. 2011
    ....
  18. doi Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease
    Katherine J E Sattler
    Institute for Pathophysiology, University Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    Basic Res Cardiol 105:821-32. 2010
    ..The HDL-C-normalized plasma level of S1P is increased in sCAD and even further in MI. This may be caused by an uptake defect of HDL for plasma S1P in CAD, and may represent a novel marker of HDL dysfunction...
  19. pmc Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    R Jasinska
    Department of Biochemistry Signal Transduction Laboratories, Lipid and Lipoprotein Research Group, University of Alberta, 357 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada
    Biochem J 340:677-86. 1999
    ..The product of LPP-1 cDNA is concluded to act partly to degrade exogenous lysophosphatidate and thereby regulate its effects on cell signalling...
  20. pmc The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
    ..Our studies establish an S1P(1)-mTOR axis that controls T cell lineage specification...
  21. pmc Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298, USA
    Nature 465:1084-8. 2010
    ..These results also highlight the key role of SphK1 and its product S1P in TNF-alpha signalling and the canonical NF-kappaB activation pathway important in inflammatory, antiapoptotic and immune processes...
  22. pmc Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
    Thomas M McIntyre
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Proc Natl Acad Sci U S A 100:131-6. 2003
    ..Moreover, LPA produced by stimulated plasma platelets activates PPARgamma in nucleated cells...
  23. ncbi Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
    Kyoko Noguchi
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Core Research for Evolutional Science and Technology CREST of Japan Science and Technology Corporation, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:25600-6. 2003
    ..These facts suggest that p2y9/GPR23 has evolved from different ancestor sequences from the Edg family...
  24. ncbi Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
    Nitai C Hait
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E Marshall St, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1758:2016-26. 2006
    ..Here we review the growing recent literature on the regulation and the roles of SphKs and S1P in apoptosis and diseases...
  25. ncbi The ins and outs of lysophosphatidic acid signaling
    Wouter H Moolenaar
    Division of Cellular Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    Bioessays 26:870-81. 2004
    ..Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis...
  26. pmc Essential role for sphingosine kinases in neural and vascular development
    Kiyomi Mizugishi
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Mol Cell Biol 25:11113-21. 2005
    ..Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases...
  27. ncbi Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
    Y Morita
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 6:1109-14. 2000
    ..Thus, the sphingomyelin pathway regulates developmental death of oocytes, and sphingosine-1-phosphate provides a new approach to preserve ovarian function in vivo...
  28. ncbi Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
    M J Lee
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington 06030 3501, USA
    Cell 99:301-12. 1999
    ..Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neovessels in vivo. These data define SPP as a novel regulator of angiogenesis...
  29. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P...
  30. doi Endothelial functions of sphingosine-1-phosphate
    Susann Lucke
    Institute of Pathophysiology, Universitatsklinikum Essen, Essen, Germany
    Cell Physiol Biochem 26:87-96. 2010
    ..We will also discuss the potential of interfering with S1P-S1P receptor interactions for the treatment of endothelial disorders and vascular pathologies...
  31. ncbi Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
    Fumikazu Okajima
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Japan
    Biochim Biophys Acta 1582:132-7. 2002
    ..Furthermore, S1P content in LDL was markedly decreased during its oxidation. This paper will discuss whether S1P is an atherogenic mediator or an anti-atherogenic mediator...
  32. doi Two pathways for lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aobayama, Aoba ku, Sendai, 980 8578, Japan
    Biochim Biophys Acta 1781:513-8. 2008
    ..One PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a novel LPA receptor called P2Y5...
  33. pmc Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking
    Maria L Allende
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:7348-58. 2011
    ..Thus, a genetic block in S1P degradation elicits a pro-inflammatory response but impairs neutrophil migration from blood into tissues...
  34. pmc Role for sphingosine kinase 1 in colon carcinogenesis
    Toshihiko Kawamori
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Ave, Ste 309, Charleston, SC 29425, USA
    FASEB J 23:405-14. 2009
    ..These results are the first in vivo evidence that the SphK1/S1P pathway contributes to colon carcinogenesis and that inhibition of this pathway is a potential target for chemoprevention...
  35. ncbi Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, and Centre National de la Recherche Scientifique, UMR6102, Marseille, France
    Nat Immunol 8:1337-44. 2007
    ..Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P5...
  36. doi Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice
    Hui Li
    Indiana University Purdue University Indianapolis, 975 West Walnut Street, Indianapolis, IN 46202, USA
    Mol Cancer Ther 8:1692-701. 2009
    ..Because ID8 cells respond to LPA similar to human EOC cells, this model is very valuable in developing and testing therapeutic reagents targeting LPA in EOC...
  37. ncbi Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Thromb Haemost 101:665-73. 2009
    ....
  38. pmc Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6
    Keisuke Yanagida
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Univerfsity of Tokyo, Tokyo, Japan
    J Biol Chem 284:17731-41. 2009
    ..A recent study has suggested that p2y5 is an LPA receptor essential for human hair growth. We confirmed that p2y5 is a functional LPA receptor and propose to designate this receptor LPA6...
  39. doi LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4
    Yao Bin Liu
    Tissue Repair, Pfizer, Inc, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 109:794-800. 2010
    ..Consistent with the ability of LPA4 to inhibit osteoblastic differentiation of stem cells, LPA4-deficient mice have increased trabecular bone volume, number, and thickness...
  40. ncbi Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 275:28398-405. 2000
    ..These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action...
  41. ncbi Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum
    Y Yatomi
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma gun
    J Biochem 121:969-73. 1997
    ....
  42. pmc Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
    Kazuaki Takabe
    From the Division of Surgical Oncology, Massey Cancer Center, Virginia Commonwealth University School ofMedicine, Richmond, Virginia 23298, USA
    J Biol Chem 285:10477-86. 2010
    ....
  43. ncbi Sphingosine-1-phosphate in cell growth and cell death
    S Spiegel
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 845:11-8. 1998
    ....
  44. pmc The vascular S1P gradient-cellular sources and biological significance
    Timothy Hla
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06001, USA
    Biochim Biophys Acta 1781:477-82. 2008
    ..From an evolutionary perspective, S1P receptors may have co-evolved with the advent of a closed vascular system and the trafficking paradigms for hematopoietic cells to navigate in and out of the vascular system...
  45. doi The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
    Christopher M Henstridge
    Centre for Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    FASEB J 23:183-93. 2009
    ..Thus, LPI is a potent and efficacious ligand at GPR55, which is likely to be a key plasma membrane mediator of LPI-mediated signaling events and changes in gene expression...
  46. doi Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters
    Ryunosuke Ohkawa
    Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan
    Ann Clin Biochem 45:356-63. 2008
    ..Thus, we attempted to develop a method of measuring the plasma Sph-1-P concentration for use in the clinical laboratory setting...
  47. pmc Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression
    Eunok Im
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Mol Cell Biol 30:2401-10. 2010
    ..These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors...
  48. pmc A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility
    Shang Zhong Xu
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Circ Res 98:1381-9. 2006
    ..The extracellular effect appears to have a primary role in S1P-evoked cell motility. The data suggest S1P sensing by TRPC5 calcium channel is a mechanism contributing to vascular smooth muscle adaptation...
  49. doi Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate
    Constantin Bode
    Institute for Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    J Cell Biochem 109:1232-43. 2010
    ....
  50. ncbi Regulation and functional roles of sphingosine kinases
    Regina Alemany
    Institut fur Pharmakologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:413-28. 2007
    ..In this review, our understanding of structure, regulation, and functional roles of SphKs is updated and discussed with regard to their implication in pathophysiological and disease states...
  51. pmc Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
    Nicole Gellings Lowe
    Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4614, USA
    Cardiovasc Res 82:303-12. 2009
    ..Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, regulates the function of numerous cell types. In this study, we determined the role of S1P in promoting pro-fibrotic actions of cardiac fibroblasts (CFs)...
  52. pmc TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells
    Andreas Gschwind
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 22:2411-21. 2003
    ..Thus, TACE can function as an effector of GPCR-mediated signalling and represents a key element of the cellular receptor cross-talk network...
  53. pmc The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
    Lauren S Whyte
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom
    Proc Natl Acad Sci U S A 106:16511-6. 2009
    ..In addition, this study also brings to light an effect of both the endogenous ligand, LPI, on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover in vivo...
  54. doi Lysophosphatidic acid (LPA) and its receptors
    Kyoko Noguchi
    The Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States
    Curr Opin Pharmacol 9:15-23. 2009
    ..In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors...
  55. ncbi Lysophosphatidic acid is a bioactive mediator in ovarian cancer
    Xianjun Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Box 317, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochim Biophys Acta 1582:257-64. 2002
    ..Thus, LPA could be a potential target for cancer therapy. This review summarizes evidence that implicates LPA in the pathophysiology of human ovarian cancer and likely other types of human malignancies...
  56. ncbi G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
    Julie Radeff-Huang
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA
    J Cell Biochem 92:949-66. 2004
    ....
  57. pmc The alliance of sphingosine-1-phosphate and its receptors in immunity
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:753-63. 2008
    ....
  58. pmc Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    Laurens A van Meeteren
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 26:5015-22. 2006
    ....
  59. ncbi The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  60. ncbi Erythrocytes store and release sphingosine 1-phosphate in blood
    Petra Hänel
    Institute for Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    FASEB J 21:1202-9. 2007
    ..Adoptively transferred S1P-loaded and unloaded mouse erythrocytes displayed a normal life span and similar S1P levels 24 h after recovery, indicating that S1P incorporation and release are dynamically regulated in vivo...
  61. ncbi Point-counterpoint of sphingosine 1-phosphate metabolism
    Julie D Saba
    Children s Hospital of Oakland Research Institute, Oakland, Calif, USA
    Circ Res 94:724-34. 2004
    ....
  62. ncbi International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    Jerold Chun
    Merck Research Laboratories, La Jolla, California 92037, USA
    Pharmacol Rev 54:265-9. 2002
    The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules...
  63. ncbi Sphingosine 1-phosphate analogs as receptor antagonists
    Michael D Davis
    Biochemistry and Molecular Genetics, Pharmacology, and Chemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:9833-41. 2005
    ..These new chemical entities will enable further understanding of S1P signaling and provide leads for further S1P receptor antagonist development...
  64. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
    ..Our results demonstrate that apoM, by delivering S1P to the S1P(1) receptor on endothelial cells, is a vasculoprotective constituent of HDL...
  65. pmc Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling
    Jun Du
    Department of Physiology, Nanjing Medical University, Nanjing, China
    PLoS ONE 5:e15940. 2010
    ..However, the underlying signaling mechanisms for LPA-induced motility of cancer cells remain to be elucidated...
  66. pmc Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Biochem J 397:461-71. 2006
    ..These results suggest that export of Sphk-1a occurs under physiological conditions and may contribute to the establishment of the vascular S1P gradient...
  67. ncbi Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
    Maria L Allende
    Genetics of Development and Disease Branch, NIDDK and NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:52487-92. 2004
    ..The results with these Sphk1 null mice reveal that some key physiologic processes that require S1P receptor signaling, such as vascular development and proper lymphocyte distribution, can occur in the absence of SPHK1...
  68. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
  69. ncbi Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
    E J Goetzl
    Departments of Medicine and Microbiology Immunology, University of California Medical Center, San Francisco, California 94143 0711, USA
    FASEB J 12:1589-98. 1998
    ..These ubiquitous LPL mediators of cellular growth, differentiation, and activities thus act directly through complex subfamilies of GPCRs and by regulating expression of biologically critical proteins...
  70. pmc GPR55 ligands promote receptor coupling to multiple signalling pathways
    Christopher M Henstridge
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Pharmacol 160:604-14. 2010
    ....
  71. ncbi Lysophospholipids are potential biomarkers of ovarian cancer
    Rebecca Sutphen
    Department of Interdisciplinary Oncology, College of Medicine and H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, 33612, USA
    Cancer Epidemiol Biomarkers Prev 13:1185-91. 2004
    To determine whether lysophosphatidic acid (LPA) and other lysophospholipids (LPL) are useful markers for diagnosis and/or prognosis of ovarian cancer in a controlled setting.
  72. pmc HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Clin Invest 113:569-81. 2004
    ..The vasoactive effects of HDL could be mimicked by three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF)...
  73. ncbi ATX-LPA receptor axis in inflammation and cancer
    Shuying Liu
    Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 8:3695-701. 2009
    ....
  74. doi Autotaxin--an LPA producing enzyme with diverse functions
    Keita Nakanaga
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aoba, Aramaki, Aoba ku, Sendai, Miyagi 980 8578, Japan
    J Biochem 148:13-24. 2010
    ..The presence of the ATX gene in other model organisms and recently developed ATX inhibitors, both of which will be definitely useful for further functional analysis of ATX, will also be mentioned...
  75. doi Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
    Timothy Hla
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Cornell University, New York, NY 10065, USA
    Neurology 76:S3-8. 2011
    ..This review highlights the normal physiologic processes modulated by S1P and S1PRs, and the therapeutic effects of S1PR modulation in the immune, central nervous, and cardiovascular systems...
  76. pmc Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
    Yutong Zhao
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 282:14165-77. 2007
    ..This involves the conversion of extracellular S1P to Sph by LPP-1, which facilitates Sph uptake, followed by the intracellular conversion of Sph to S1P by SphK1...
  77. doi The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    Atsuo Kawahara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Science 323:524-7. 2009
    ..Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration...
  78. pmc Sphingosine 1-phosphate signalling in mammalian cells
    S Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK
    Biochem J 349:385-402. 2000
    ..This article describes where the research field is in relation to achieving this aim...
  79. pmc Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay
    Hong Yin
    GPCR Platform, Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    J Biol Chem 284:12328-38. 2009
    ..The anti-inflammatory effect of 3,3'-diindolylmethane in RAW264.7 cells was shown to be partially mediated by CB(2)...
  80. pmc Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    Trung H M Pham
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:17-27. 2010
    ..Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P required for lymphocyte egress from LNs and Peyer's patches, and suggest a role for S1P in lymphatic vessel maturation...
  81. ncbi Physiological and pathological actions of sphingosine 1-phosphate
    Timothy Hla
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Semin Cell Dev Biol 15:513-20. 2004
    ....
  82. ncbi A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid
    Hirofumi Sonoda
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:34254-63. 2002
    ..In the latter condition, an increased level of LPA, but not other lysophospholipids, was confirmed by mass spectrometry analyses...
  83. pmc Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
    Poulami Mitra
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 103:16394-9. 2006
    ..Transport of S1P by ABCC1 influenced migration of mast cells toward antigen but not degranulation. These findings have important implications for S1P functions in mast cell-mediated immune responses...
  84. ncbi Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist
    Makoto Osada
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
    Biochem Biophys Res Commun 299:483-7. 2002
    ....
  85. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  86. ncbi Beta-catenin, cancer, and G proteins: not just for frizzleds anymore
    Craig C Malbon
    Department of Pharmacology, School of Medicine, Health Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Sci STKE 2005:pe35. 2005
    ..The ability of LPA to increase the cytoplasmic and nuclear accumulation of beta-catenin provides a new dimension of knowledge linking lipid mediators to the dysregulation of beta-catenin signaling in cancer...
  87. pmc Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium
    Jun Kunisawa
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 204:2335-48. 2007
    ..These data are the first to demonstrate that a lipid-mediated system discriminates IELs originating from conventional and unconventional thymic precursors...
  88. doi Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis
    Hong Bin Liu
    Department of Pharmacology, Tianjin Institute of Acute Abdominal Diseases, Tianjin, China
    Pancreas 36:e10-5. 2008
    ..To investigate the effects of sphingosine-1-phosphate (S1P) and its analogue FTY720 on the lung injury induced by acute necrotizing pancreatitis in rats...
  89. ncbi Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase
    Christelle Benaud
    Lombardi Cancer Center and Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Biol Chem 277:10539-46. 2002
    ..Our results demonstrate that bioactive phospholipids can function as nonprotein activators of a cell surface protease, suggesting a possible mechanistic link between S1P and normal and possibly pathologic tissue remodeling...
  90. ncbi Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation
    Nicolas Ancellin
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    J Biol Chem 277:6667-75. 2002
    ..These findings suggest that S1P is made in the extracellular milieu and that extracellular export of SK contributes to the action of S1P in the vascular system...
  91. pmc Insights into the pharmacological relevance of lysophospholipid receptors
    Tetsuji Mutoh
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA
    Br J Pharmacol 165:829-44. 2012
    ..Continued basic and translational research on LP signalling should provide novel insights into both basic biological mechanisms, as well as novel therapeutic approaches to combat a range of human diseases...
  92. ncbi Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
    Akira Tokumura
    Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770 8505, Japan
    J Biol Chem 277:39436-42. 2002
    ....
  93. doi Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta
    Yuki Iwasawa
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Am J Reprod Immunol 62:90-5. 2009
    ..However, the source of increased ATX during pregnancy is still uncertain. We hypothesized that the source of increased ATX might be placenta...
  94. ncbi Unfolding the pathophysiological role of bioactive lysophospholipids
    Yan Xu
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:23-32. 2003
    b>Lysophospholipids (LPLs), including glycerol- and sphingoid-based lipids, stimulate cell signaling and play important pathophysiological roles in humans and other animals...
  95. pmc S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism
    A Kumar
    Center for Cancer Research, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    Cell Death Dis 2:e119. 2011
    ..Our findings reveal SPL to be a regulator of ASMase, the G2 checkpoint and DNA repair and a novel target for radioprotection...
  96. doi Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia
    Yu Zeng
    Department of Urology, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    Prostate 69:283-92. 2009
    ..To elucidate gene expression profiles of lysophosphatidic acid (LPA)-related molecules in cancer, pre-cancerous lesion, and benign hyperplasia of the prostate...
  97. pmc Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
    ..Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development...
  98. doi Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA
    Carlos Ocaña-Morgner
    Faculty of Medicine Carl Gustav Carus, Institute of Physiological Chemistry, Dresden University of Technology, D 01307 Dresden, Germany
    J Immunol 186:5345-55. 2011
    ..These data demonstrate SWAP-70 as a novel regulator of S1P signaling necessary for DC motility and endocytosis...
  99. ncbi Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells
    James R Van Brocklyn
    Department of Pathology, The Ohio State University, 4164 Graves Hall, 333 W 10th Ave, Columbus, OH 43210, USA
    Cancer Lett 199:53-60. 2003
    ..S1P is present at high levels in brain tissue. Thus it is possible that autocrine or paracrine signaling by S1P through its G protein-coupled receptors enhances both glioma cell proliferation and invasiveness...
  100. pmc Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice
    Myat Lin Oo
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
    J Clin Invest 121:2290-300. 2011
    ....
  101. pmc Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids
    Y Majeed
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 162:1509-20. 2011
    ..Steroids are known to modulate fear and anxiety states, and we therefore investigated whether TRPC5 exhibited sensitivity to steroids...

Research Grants80

  1. Novel Roles for Lysophospholippids in Eukaryotic Membrane Biogenesis and Turnover
    Dennis R Voelker; Fiscal Year: 2010
    b>Lysophospholipids constitute a class of membrane glycerophospholipids that are rapidly transported and metabolized by many eukaryotic cells ranging from yeast to humans...
  2. Group V sPla2 in Inflammation and Innate Immunity
    Barbara Balestrieri; Fiscal Year: 2007
    ..A2 are a family of enzymes that hydrolyze membrane phospholipids to generate free fatty acids and lysophospholipids. They are involved in a wide range of processes such as inflammation, phospholipid remodeling, cell ..
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Suzanne Scarlata; Fiscal Year: 2007
    ..Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in ..
  4. Newborn Screening for Adrenoleukodystrophy
    Gerald Raymond; Fiscal Year: 2009
    ..we have recently developed a tandem mass spectrometry methodology that can detect altered elevations in lysophospholipids. This methodology is adaptable to regional newborn screening of metabolic disorders offering early diagnosis ..
  5. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2010
    Phospholipids and lysophospholipids are known to act as lipid mitogens that regulate cell proliferation and survival signaling pathways...
  6. Newborn Screening for Adrenoleukodystrophy
    Gerald V Raymond; Fiscal Year: 2010
    ..we have recently developed a tandem mass spectrometry methodology that can detect altered elevations in lysophospholipids. This methodology is adaptable to regional newborn screening of metabolic disorders offering early diagnosis ..
  7. Immortalization of Pregnant Human Myometrial Cells
    MELVYN SOLOFF; Fiscal Year: 2004
    ..Akt phosphorylation in response to insulin treatment, stimulation of myometrial cell growth by lysophospholipids, quantification of oxytocin receptor ligand binding sites and upregulation by lysophosphatidic acid, ..
  8. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
    ..Contractile agonists (lysophospholipids and thrombin), TGF beta, extracellular matrix (ECM) proteins and increased intraocular pressure, all ..
  9. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2010
    ..Contractile agonists (lysophospholipids and thrombin), TGF beta, extracellular matrix (ECM) proteins and increased intraocular pressure, all ..
  10. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
    ..Contractile agonists (lysophospholipids and thrombin), TGF beta, extracellular matrix (ECM) proteins and increased intraocular pressure, all ..
  11. LPA and Edg Receptors in the Pulmonary Immune Respose
    Steve Georas; Fiscal Year: 2007
    The enzymatic metabolism of membrane glycerophospholipids generates bioactive lysophospholipids including lysophosphatidic acid (LPA)...
  12. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Andrew Morris; Fiscal Year: 2004
    ..Phospholipases A generate fatty acids and lysophospholipids. These enzymes initiate production of receptor-active lipids including lysophosphatidic acid and the ..
  13. Rho and G12 in thrombin and lysophospholipid signaling
    JOAN BROWN; Fiscal Year: 2007
    A subset of G-protein coupled receptors, including those for thrombin and the lysophospholipids S1P and LPA, have a remarkable capacity to promote DNA synthesis and actin cytoskeletal rearrangement in mammalian cells...
  14. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2007
    ..have both basic and potentially therapeutic relevance to diseases associated with peripheral myelination: lysophospholipids, small signaling lipids that include lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), ..
  15. LIPID MEDIATORS OF SIGNAL TRANSDUCTION IN SMOOTH MUSCLE
    Richard Gross; Fiscal Year: 1992
    ..g lysophospholipids, phosphatidic acid, free fatty acids and diglycerides)...
  16. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  17. Non-COX Arachidonic Acid Metabolites and Angiogenesis
    GADIPARTHI RAO; Fiscal Year: 2007
    ..Phospholipase A2s (PLA2s), a group of enzymes that breakdown phospholipids generating arachidonic acid and lysophospholipids have been implicated in inflammation...
  18. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY MUSLIN; Fiscal Year: 2009
    ..expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  19. EICOSANOIDS, ANGIOGENESIS, AND RETINOPATHY
    GADIPARTHI RAO; Fiscal Year: 2007
    ..Phospholipase A2s (PLA2s), a group of enzymes that break down phospholipids generating arachidonic acid and lysophospholipids have been implicated in inflammation...
  20. Characterization of a Novel Lysophospholipase
    Ying Huang; Fiscal Year: 2003
    Numerous studies have demonstrated that phospholipids and lysophospholipids act as lipid mitogens that affect cell proliferation and survival by altering various cell signaling pathways...
  21. EICOSANOIDS, ANGIOGENESIS, AND RETINOPATHY
    GADIPARTHI RAO; Fiscal Year: 2006
    ..Phospholipase A2s (PLA2s), a group of enzymes that break down phospholipids generating arachidonic acid and lysophospholipids have been implicated in inflammation...