dimyristoylphosphatidylcholine

Summary

Summary: A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.

Top Publications

  1. pmc Structure of lipid bilayers
    J F Nagle
    Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biochim Biophys Acta 1469:159-95. 2000
  2. pmc Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis
    Yuji Komizu
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan
    Int J Nanomedicine 6:1913-20. 2011
  3. pmc Automated builder and database of protein/membrane complexes for molecular dynamics simulations
    Sunhwan Jo
    Department of Chemistry, The University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 2:e880. 2007
  4. ncbi Histological bioanalysis for therapeutic effects of hybrid liposomes on the hepatic metastasis of colon carcinoma in vivo
    Hideaki Ichihara
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4 22 1, Ikeda, Kumamoto 860 0082, Japan
    Int J Pharm 394:174-8. 2010
  5. ncbi A molecular dynamics simulation study of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayer
    Liwei Li
    Department of Materials Science and Engineering, University of Utah, Salt Lake City, Utah 84112, USA
    J Phys Chem B 111:4067-72. 2007
  6. pmc Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I
    John B Massey
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochim Biophys Acta 1781:245-53. 2008
  7. ncbi An improved united atom force field for simulation of mixed lipid bilayers
    See Wing Chiu
    Department of Molecular and Integrative Physiology, National Center for Supercomputing Applications, University of Illinois, Urbana, Illinois 61801, USA
    J Phys Chem B 113:2748-63. 2009
  8. ncbi Interaction of linear mono- and diamines with dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol multilamellar liposomes
    F Momo
    Department of Physical Chemistry, University of Venice, Italy
    Arch Biochem Biophys 382:224-31. 2000
  9. ncbi NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein
    Henrik Biverståhl
    Department of Biochemistry and Biophysics, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden
    Biochemistry 43:14940-7. 2004
  10. ncbi [Chemotherapy with hybrid liposomes without any drug in vivo]
    Hideaki Ichihara
    Graduate Course of Applied Chemistry, Sojo University, 4 22 1, Ikeda, Kumamoto 860 0082, Japan
    Yakugaku Zasshi 123:25-34. 2003

Research Grants

  1. Development of Biomedical EPR Instrumentation
    James S Hyde; Fiscal Year: 2013
  2. A Structural/Functional Study on Cholesterol's Regulation of Alzheimer's Disease
    Paul J Barrett; Fiscal Year: 2013
  3. CYTOCHROME P450 SUBSTRATE SITING AND MOTION
    Ann McDermott; Fiscal Year: 2002
  4. CHAIN DYNAMICS IN LIPID BILAYERS AND MICELLES
    MICHAEL FUSON; Fiscal Year: 1991
  5. APOLIPOPROTEIN E AND A 1 LIPID COMPLEX STRUCTURES
    Karl Weisgraber; Fiscal Year: 2003
  6. IMMUNE RESPONSES TO MEMBRANES: PHYSICOCHEMICAL STUDIES
    GILLIAN HUMPHRIES; Fiscal Year: 1980
  7. Purchase of a 500 MHz Solid State NMR Spectrometer
    Ayyalusamy Ramamoorthy; Fiscal Year: 2007
  8. Structure and function of antimicrobial peptides
    Ayyalusamy Ramamoorthy; Fiscal Year: 2008
  9. Controlled Drug Delivery to Colon Tumors Via Ultrasound
    WILLIAM PITT; Fiscal Year: 2006
  10. NMR of basic-aromatic clusters
    Steven Smith; Fiscal Year: 2007

Detail Information

Publications240 found, 100 shown here

  1. pmc Structure of lipid bilayers
    J F Nagle
    Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biochim Biophys Acta 1469:159-95. 2000
    ..The uncertainty in structural results for lipid bilayers is being reduced and best current values are provided for bilayers of five lipids...
  2. pmc Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis
    Yuji Komizu
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan
    Int J Nanomedicine 6:1913-20. 2011
    ..Hybrid liposomes can be prepared by simply sonicating a mixture of vesicular and micellar molecules in buffer solutions. In this study, we investigated the effects of hybrid liposomes on the growth of human colon cancer cells in vitro...
  3. pmc Automated builder and database of protein/membrane complexes for molecular dynamics simulations
    Sunhwan Jo
    Department of Chemistry, The University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 2:e880. 2007
    ..Therefore, Membrane Builder provides the intuitive and easy way to build and simulate the biologically important membrane system...
  4. ncbi Histological bioanalysis for therapeutic effects of hybrid liposomes on the hepatic metastasis of colon carcinoma in vivo
    Hideaki Ichihara
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4 22 1, Ikeda, Kumamoto 860 0082, Japan
    Int J Pharm 394:174-8. 2010
    Therapeutic effects of hybrid liposomes (HL) composed of l-alpha-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (23) dodecylether (C(12)(EO)(23)) on the metastasis of colon carcinoma (Colon26) cells were examined in vivo...
  5. ncbi A molecular dynamics simulation study of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayer
    Liwei Li
    Department of Materials Science and Engineering, University of Utah, Salt Lake City, Utah 84112, USA
    J Phys Chem B 111:4067-72. 2007
    We have carried out atomistic molecular dynamics simulations of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayer and an alkane melt...
  6. pmc Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I
    John B Massey
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochim Biophys Acta 1781:245-53. 2008
    ..The size speciation of rHDL and probably nascent HDL formed via the activity of the ABCA1 lipid transporter is mechanistically linked to the cholesterol content of the membranes from which they were formed...
  7. ncbi An improved united atom force field for simulation of mixed lipid bilayers
    See Wing Chiu
    Department of Molecular and Integrative Physiology, National Center for Supercomputing Applications, University of Illinois, Urbana, Illinois 61801, USA
    J Phys Chem B 113:2748-63. 2009
    ..43-A1-S3 compares favorably with other force fields used in conjunction with the Gromacs simulation package with respect to the breadth of phenomena that it accurately reproduces...
  8. ncbi Interaction of linear mono- and diamines with dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol multilamellar liposomes
    F Momo
    Department of Physical Chemistry, University of Venice, Italy
    Arch Biochem Biophys 382:224-31. 2000
    The effect of linear monoamines on dimyristoylphosphatidylglycerol and dimyristoylphosphatidylcholine multilamellar liposomes was studied as a function of their length and compared with the behavior of linear carboxylic acids...
  9. ncbi NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein
    Henrik Biverståhl
    Department of Biochemistry and Biophysics, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden
    Biochemistry 43:14940-7. 2004
    ..These findings may lead to a better understanding of how the prion protein accumulates at the membrane surface and also how the conversion into the scrapie form is carried out...
  10. ncbi [Chemotherapy with hybrid liposomes without any drug in vivo]
    Hideaki Ichihara
    Graduate Course of Applied Chemistry, Sojo University, 4 22 1, Ikeda, Kumamoto 860 0082, Japan
    Yakugaku Zasshi 123:25-34. 2003
    ..with B-16 melanoma cells after the intraperitoneal treatment with hybrid liposomes composed of L-alpha-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylenedodecyl ether (C12(EO)n, n = 10 and 23 respectivery) which had a uniform and ..
  11. ncbi Force field dependence of phospholipid headgroup and acyl chain properties: comparative molecular dynamics simulations of DMPC bilayers
    Priyanka Prakash
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India
    J Comput Chem 31:266-77. 2010
    ..The headgroup properties are likely to play a significant role in lipid-lipid, protein-lipid, and ligand-lipid interactions and hence headgroup parameters in phospholipids require refinement for both Berger and CHARMM force fields...
  12. ncbi Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes
    Yuji Komizu
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4 22 1 Ikeda, Kumamoto 860 0082, Japan
    Biochem Biophys Res Commun 418:81-6. 2012
    Hybrid liposomes (HLs), composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether, have selectively inhibited the growth of human hepatocellular carcinoma (HCC) cells without affecting normal hepatocytes ..
  13. ncbi Inhibitory effect of drug-free hybrid liposomes on metastasis of human neuroblastoma
    Jyoji Yoshizawa
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Surg Int 27:379-84. 2011
    ..The present study was designed to determine whether a drug-free hybrid liposome composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylenealkyl ether (EO) [90 mol% DMPC/10% C(12)(EO)(21) (HL21), 90 mol% DMPC/10% C(..
  14. ncbi Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis
    Yuji Komizu
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, Japan
    Bioorg Med Chem Lett 21:3962-5. 2011
    Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first ..
  15. ncbi Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis
    Hideki Kitajima
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan
    Bioorg Med Chem Lett 22:1784-7. 2012
    Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and ..
  16. ncbi Effect of the β-propiolactone treatment on the adsorption and fusion of influenza A/Brisbane/59/2007 and A/New Caledonia/20/1999 virus H1N1 on a dimyristoylphosphatidylcholine/ganglioside GM3 mixed phospholipids monolayer at the air-water interface
    Bernard Desbat
    CBMN, UMR CNRS 5248, Universite Bordeaux, IPB, Allée Geoffroy Saint Hilaire 33600 Pessac, France
    Langmuir 27:13675-83. 2011
    ..Our data also indicate that BPL chemically modifies hemagglutinin, which mediates the interaction with GM3...
  17. pmc Structural evaluation of phospholipid bicelles for solution-state studies of membrane-associated biomolecules
    K J Glover
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0359, USA
    Biophys J 81:2163-71. 2001
    ..techniques have been used to characterize the aggregate structures formed in solutions containing dimyristoylphosphatidylcholine (DMPC)/dihexanoylphosphatidylcholine (DHPC) at ratios of < or =0...
  18. ncbi Aggregate properties of sodium deoxycholate and dimyristoylphosphatidylcholine mixed micelles
    Jasmeet Singh
    Department of Physics and Center for Supramolecular Studies, California State University, Northridge, California 91330 8268, USA
    J Phys Chem B 112:3997-4008. 2008
    Mixed micelles of the phospholipid dimyristoylphosphatidylcholine (DMPC) and bile salts of sodium deoxycholate (NaDC) were investigated by a combination of techniques, including time-resolved fluorescence quenching (TRFQ), electron spin ..
  19. pmc Determination of the orientation and dynamics of ergosterol in model membranes using uniform 13C labeling and dynamically averaged 13C chemical shift anisotropies as experimental restraints
    O Soubias
    Institut de Pharmacologie et de Biologie Structurale, UMR 5089, Toulouse, France
    Biophys J 89:1120-31. 2005
    A new strategy was established to determine the average orientation and dynamics of ergosterol in dimyristoylphosphatidylcholine model membranes...
  20. pmc Phosphorus-31 two-dimensional solid-state exchange NMR. Application to model membrane and biological systems
    D B Fenske
    Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Biophys J 59:55-69. 1991
    ..e., any local surface perturbations are either present in small number or have little effect on the mean orientation of the phospholipids with respect to the membrane normal...
  21. ncbi Long-term-stable ether-lipid vs conventional ester-lipid bicelles in oriented solid-state NMR: altered structural information in studies of antimicrobial peptides
    Kresten Bertelsen
    Center for Insoluble Protein Structures inSPIN, Interdisciplinary Nanoscience Center iNANO, Aarhus University, DK 8000 Aarhus C, Denmark
    J Phys Chem B 115:1767-74. 2011
    ..In more general terms, the results underscore the necessity in structural biology to address both the protein and its environments in studies relating structure to function...
  22. ncbi Synthetic dimyristoylphosphatidylcholine liposomes assimilating into high-density lipoprotein promote regression of atherosclerotic lesions in cholesterol-fed rabbits
    Byung H Simon Cho
    Harlan E Moore Heart Research Foundation, Champaign, IL 61820, USA
    Exp Biol Med (Maywood) 235:1194-203. 2010
    ..g/mL) plasma fraction from cholesterol-fed rabbits to assimilate multilamellar liposomes of synthetic dimyristoylphosphatidylcholine (DMPC)...
  23. ncbi Molecular simulation of the DMPC-cholesterol phase diagram
    Frédérick J M de Meyer
    Department of Chemical Engineering, University of California, Berkeley, 101B Gilman Hall, Berkeley, California 94720 1462, USA
    J Phys Chem B 114:10451-61. 2010
    In this paper, we present a coarse-grained model of a hydrated saturated phospholipid bilayer (dimyristoylphosphatidylcholine, DMPC) containing cholesterol that we study using a hybrid dissipative particle dynamics-Monte Carlo method...
  24. ncbi Interpretation of small angle X-ray measurements guided by molecular dynamics simulations of lipid bilayers
    Jonathan N Sachs
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chem Phys Lipids 126:211-23. 2003
    ..In this way we are able to remove some of the restrictions imposed by limited scattering data in constructing reliable electron density profiles...
  25. ncbi Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy
    Daniel Huster
    Junior Research Group Solid State NMR Studies of Membrane Associated Proteins, University of Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    J Am Chem Soc 125:4070-9. 2003
    ....
  26. pmc Structure of gel phase DMPC determined by X-ray diffraction
    Stephanie Tristram-Nagle
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213 USA
    Biophys J 83:3324-35. 2002
    The structure of fully hydrated gel phase dimyristoylphosphatidylcholine lipid bilayers was obtained at 10 degrees C. Oriented lipid multilayers were used to obtain high signal-to-noise intensity data...
  27. ncbi Pore formation coupled to ion transport through lipid membranes as induced by transmembrane ionic charge imbalance: atomistic molecular dynamics study
    Andrey A Gurtovenko
    Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, P O Box 1100, FI 02015 HUT, Finland
    J Am Chem Soc 127:17570-1. 2005
    ..The findings highlight the importance of ionic charge fluctuations in spontaneous pore formation and their role in ion leakage through protein-free lipid membranes...
  28. ncbi Cholesterol in bilayers with PUFA chains: doping with DMPC or POPC results in sterol reorientation and membrane-domain formation
    Norbert Kucerka
    Canadian Neutron Beam Centre, National Research Council, Chalk River, Ontario K0J 1J0, Canada
    Biochemistry 49:7485-93. 2010
    ..e., flat orientation). These results lend credence to DMPC's aversion for PUFAs, supporting the notion that domain formation is primarily driven by lipids...
  29. ncbi Specific accumulation and growth inhibitory effects of hybrid liposomes to hepatoma cells in vitro
    Koji Nakano
    Graduate School of Applied Chemistry, Sojo University, Kumamoto, Japan
    Bioorg Med Chem Lett 12:3251-4. 2002
    Specific accumulation and growth inhibitory effects of hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine and 10 mol% polyoxyethylene(23)dodecyl ether were obtained in human hepatoma cells without affecting normal liver ..
  30. ncbi Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer
    Alemayehu A Gorfe
    Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093 0365, USA
    J Med Chem 50:674-84. 2007
    ..The implications of the results to membrane lateral segregation and other aspects of Ras signaling are discussed...
  31. ncbi 31P NMR and AFM studies on the destabilization of cell and model membranes by the major bovine seminal plasma protein, PDC-109
    Rajani S Damai
    School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
    IUBMB Life 62:841-51. 2010
    The effect of PDC-109 binding to dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) and supported membranes was investigated by (31)P NMR spectroscopy and atomic force microscopy...
  32. pmc Correlation of membrane binding and hydrophobicity to the chaperone-like activity of PDC-109, the major protein of bovine seminal plasma
    Rajeshwer S Sankhala
    School of Chemistry, University of Hyderabad, Hyderabad, Andhra Pradesh, India
    PLoS ONE 6:e17330. 2011
    ..These results underscore the relevance of phospholipid binding and hydrophobicity to the chaperone-like activity of PDC-109...
  33. ncbi Characterization of phospholipid mixed micelles by translational diffusion
    James J Chou
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    J Biomol NMR 29:299-308. 2004
    ....
  34. ncbi Induction of apoptosis by hybrid liposomes for human breast tumor cells along with activation of caspases
    Hideaki Nagami
    Graduate Course of Applied Chemistry, Sojo University, 4 22 1 Ikeda, Kumamoto 860 0082, Japan
    Biol Pharm Bull 29:380-1. 2006
    ..Highly inhibitory effects of hybrid liposomes on the growth of human breast tumor cells in vitro were obtained. It is worthy to note that induction of apoptosis through activation of caspases by hybrid liposomes was clearly observed...
  35. ncbi Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells
    Yoko Matsumoto
    Graduate Course of Applied Chemistry, Sojo University, Ikeda, Kumamoto, Japan
    Int J Cancer 115:377-82. 2005
    ..Hybrid liposomes composed of dimyristoylphosphatidylcholine and polyoxyethylene (10) dodecyl ether were found to inhibit the growth of human promyelocytic ..
  36. ncbi Modification of the CHARMM force field for DMPC lipid bilayer
    Carl Johan Högberg
    Division of Physical Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SE 10691, Sweden
    J Comput Chem 29:2359-69. 2008
    ....
  37. ncbi Induction of apoptosis of human lung carcinoma cells by hybrid liposomes containing polyoxyethylenedodecyl ether
    Yasunori Iwamoto
    Graduate Course of Applied Chemistry, Sojo University, 4 22 1 Ikeda, Kumamoto 860 0082, Japan
    Int J Pharm 292:231-9. 2005
    ..A clear solution of hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(23)dodecyl ether (C12(EO)23) having a hydrodynamic diameter of 100-..
  38. ncbi A molecular dynamics investigation of the influence of hydration and temperature on structural and dynamical properties of a dimyristoylphosphatidylcholine bilayer
    Carl Johan Högberg
    Division of Physical Chemistry, Arrhenius Laboratory, Stockholm University, S 106 91 Stockholm, Sweden
    J Phys Chem B 110:14326-36. 2006
    A series of molecular dynamics simulations of dimyristoylphosphatidylcholine bilayers, with different levels of hydration and temperature, were performed to examine the influence of hydration on properties of lipid membranes...
  39. ncbi Peptide insertion, positioning, and stabilization in a membrane: insight from an all-atom molecular dynamics simulation
    Arneh Babakhani
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093 0365, USA
    Biopolymers 85:490-7. 2007
    ..Finally, the diffusion rate of the peptides in the membrane plane is calculated (based on experimental peptide concentrations) to be approximately 6 A(2)/ns, thus suggesting a 500 ns time scale for intermolecular interactions...
  40. ncbi Spin-label electron spin resonance studies on the mode of anchoring and vertical location of the N-acyl chain in N-acylphosphatidylethanolamines
    M J Swamy
    School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
    Biochemistry 39:12476-84. 2000
    ..Further, similar conclusions are reached when the ESR spectra of the N-acyl PE spin-labels in dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylethanolamine (DMPE) host matrixes are compared with those of ..
  41. ncbi Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo
    Tomomi Towata
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan
    Leuk Res 34:906-11. 2010
    ..Hybrid liposomes (HL), composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene dodecyl ether, inhibited PEL cell proliferation and induced apoptosis in ..
  42. ncbi Hybrid liposomes inhibit the growth of cholangiocarcinoma by induction of cell cycle arrest in G1 phase
    Tomomi Towata
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan
    Bioorg Med Chem Lett 20:3680-2. 2010
    ..arrest were observed in human cholangiocarcinoma cells by hybrid liposomes composed of 90 mol% L-alpha-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(21)dodecyl ether (C(12)(EO)(21)) without affecting normal ..
  43. pmc Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles
    Norbert Kucerka
    Physics Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Biophys J 88:2626-37. 2005
    Quantitative structures of the fully hydrated fluid phases of dimyristoylphosphatidylcholine (DMPC) and dilauroylphosphatidylcholine (DLPC) were obtained at 30 degrees C...
  44. pmc Mechanisms of passive ion permeation through lipid bilayers: insights from simulations
    Harald L Tepper
    FOM Institute for Atomic and Molecular Physics, AMOLF, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands
    J Phys Chem B 110:21327-37. 2006
    ..Permeability differences between anions and cations through phosphatidylcholine bilayers are correlated with suppression of favorable membrane breathing modes by cations...
  45. ncbi Molecular packing in 1-hexanol-DMPC bilayers studied by molecular dynamics simulation
    Ulf R Pedersen
    Department of Life Sciences and Chemistry and MEMPHYS, Center for Biomembrane Physics, Roskilde University, 1 Universitetsvej, PO Box 260, DK 4000 Roskilde, Denmark
    Biophys Chem 125:104-11. 2007
    ..The net effect in the core is a 2-3% decrease in density corresponding to a total volume increase of approximately 14 cm(3) mol(-1) hexanol partitioned...
  46. pmc Membrane insertion and lipid-protein interactions of bovine seminal plasma protein PDC-109 investigated by spin-label electron spin resonance spectroscopy
    M Ramakrishnan
    School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
    Biophys J 81:2215-25. 2001
    The interaction of the major acidic bovine seminal plasma protein, PDC-109, with dimyristoylphosphatidylcholine (DMPC) membranes has been investigated by spin-label electron spin resonance spectroscopy...
  47. ncbi Ions and counterions in a biological channel: a molecular dynamics simulation of OmpF porin from Escherichia coli in an explicit membrane with 1 M KCl aqueous salt solution
    Wonpil Im
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 319:1177-97. 2002
    ..The presence of K+ in the pore screens the negative electrostatic potential arising from OmpF to help the translocation of Cl- by formation of ion pairs...
  48. ncbi Calorimetric and spectroscopic studies of the phase behavior and organization of lipid bilayer model membranes composed of binary mixtures of dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol
    Ruthven N A H Lewis
    Department of Biochemistry, University of Alberta, Edmonton, AB, Canada T6G 2H7
    Biochim Biophys Acta 1668:203-14. 2005
    The thermotropic phase behavior of hydrated bilayers derived from binary mixtures of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) was investigated by differential scanning calorimetry, Fourier-transform ..
  49. ncbi Assembly of single bacteriorhodopsin trimers in bilayer nanodiscs
    Timothy H Bayburt
    Department of Biochemistry, University of Illinois, 116 Morrill Hall, 505 S Goodwin, Urbana, IL 61801, USA
    Arch Biochem Biophys 450:215-22. 2006
    ..These nanoscale bilayers offer the opportunity to understand and control the assembly of oligomeric integral membrane proteins critical to macromolecular recognition and cellular signaling...
  50. ncbi Physical properties of phosphatidylcholine vesicles containing small amount of sodium cholate and consideration on the initial stage of vesicle solubilization
    Changqi Sun
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 50:1145-50. 2002
    ..ESR spectra of 12-doxylstearic acid (12-DS) in phosphatidylcholine from egg yolk (EPC) or dimyristoylphosphatidylcholine (DMPC) SUV at low concentrations (insufficient to destroy the vesicles) of Na-chol were composed of ..
  51. ncbi Effect of cholesterol on the interaction of seminal plasma protein, PDC-109 with phosphatidylcholine membranes
    Musti J Swamy
    School of Chemistry, University of Hyderabad, India
    FEBS Lett 528:230-4. 2002
    ..The selectivity of PDC-109 for different spin-labelled phospholipids and sterol probes in dimyristoylphosphatidylcholine (DMPC) host matrix has been characterized earlier by EPR spectroscopy [Ramakrishnan, M., Anbazhagan, V...
  52. ncbi Membrane localization and flexibility of a lipidated ras peptide studied by molecular dynamics simulations
    Alemayehu A Gorfe
    Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Am Chem Soc 126:15277-86. 2004
    ..The peptide in the membrane is rather rigid over the simulation time scale of about 10 ns, but different partially extended conformations devoid of backbone hydrogen bonds are observed in different trajectories...
  53. ncbi Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization
    Mark L Segall
    Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Lipid Res 43:1688-700. 2002
    ..They suggest that flexibility in an apolipoprotein molecule increases the time-averaged exposure of hydrophobic surface area, thereby increasing the rate of phospholipid solubilization...
  54. ncbi Orientation and conformational preference of leucine-enkephalin at the surface of a hydrated dimyristoylphosphatidylcholine bilayer: NMR and MD simulation
    Indira Chandrasekhar
    Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    J Am Chem Soc 128:159-70. 2006
    The morphogenic opiate pentapeptide leucine-enkephalin (lenk) in a hydrated dimyristoylphosphatidylcholine (DMPC) bilayer is studied using NMR spectroscopy and molecular dynamics simulation...
  55. pmc Simulation-based methods for interpreting x-ray data from lipid bilayers
    Jeffery B Klauda
    Laboratory of Computational Biology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 90:2796-807. 2006
    ..This approach is independent of structural models and could be used to determine structural properties of bilayers with different lipids, cholesterol, and peptides...
  56. ncbi Determination of the oligomeric number and intermolecular distances of membrane protein assemblies by anisotropic 1H-driven spin diffusion NMR spectroscopy
    Wenbin Luo
    Department of Chemistry, Iowa State University, Gilman 0108, Ames, Iowa 50011, USA
    J Am Chem Soc 128:7242-51. 2006
    ..Thus, the CODEX technique presents a general method for determining the oligomeric number and intermolecular distances in the approximately 10 angstroms range in membrane proteins and other complex biological assemblies...
  57. pmc H-ras protein in a bilayer: interaction and structure perturbation
    Alemayehu A Gorfe
    Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, and Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0365, USA
    J Am Chem Soc 129:12280-6. 2007
    ..The results provide structural arguments in support of the proposed participation of ras in the organization of membrane nanoclusters...
  58. ncbi Incorporation of antimicrobial peptides into membranes: a combined liquid-state NMR and molecular dynamics study of alamethicin in DMPC/DHPC bicelles
    Jens Dittmer
    Center for Insoluble Protein Structures inSPIN, Department of Chemistry, University of Aarhus, Denmark
    J Phys Chem B 113:6928-37. 2009
    ..The MD simulations provide a statistical base that reflects our NMR data and even can explain some initially surprising NMR results concerning specific interactions between alamethicin and the lipids...
  59. pmc Molecular dynamics simulations of a DMPC bilayer using nonadditive interaction models
    Joseph E Davis
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA
    Biophys J 96:385-402. 2009
    ..We present results of molecular dynamics simulations of a solvated dimyristoylphosphatidylcholine bilayer using this polarizable force field as well as the nonpolarizable, fixed-charge CHARMM27 and ..
  60. ncbi Enhanced delivery of adenovirus, using proteoliposomes containing wildtype or V156K apolipoprotein A-I and dimyristoylphosphatidylcholine
    Ki Hoon Park
    School of Biotechnology, Aging Associated Vascular Disease Research Center, Yeungnam University, Gyeongsan 712 749, South Korea
    Hum Gene Ther 21:579-87. 2010
    ..to enhance delivery efficiency, proteoliposomes (PLs) containing adenovirus (Ad) were synthesized with dimyristoylphosphatidylcholine (DMPC), cholesterol, and apolipoprotein A-I (apoA-I)...
  61. ncbi Effects of the nonimmobilizer hexafluroethane on the model membrane dimyristoylphosphatidylcholine
    Laure Koubi
    Center for Molecular Modeling, Department of Chemistry, University of Pennsylvania, Philadelphia, 19104 6323, USA
    Anesthesiology 97:848-55. 2002
    ..Such modification may play a role in the mechanism of anesthesia, and may therefore be related to the differences in their clinical behavior...
  62. ncbi Thermodynamic and real-space structural evidence of a 2D critical point in phospholipid monolayers
    Lars K Nielsen
    Radiometer Medical, Akandevej 21, DK 2700 Brønshøj, Denmark
    Langmuir 23:11684-92. 2007
    ..Additional results are presented demonstrating the presence of striped phases and coexisting domains in binary mixtures...
  63. pmc Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers
    Conggang Li
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32310, USA
    Biophys J 94:1295-302. 2008
    ..The lipid headgroup orientation changes on drug binding as characterized by the anisotropy of (31)P chemical shielding and (14)N quadrupolar interactions and by the MD simulation...
  64. ncbi Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis
    Tomomi Towata
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4 22 1 Ikeda, Kumamoto 860 0082, Japan
    Biochem Biophys Res Commun 393:445-8. 2010
    ..Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C12(EO)21) (HL-21), were rapidly accumulated in the ..
  65. pmc Undulation contributions to the area compressibility in lipid bilayer simulations
    Qaiser Waheed
    Theoretical Biological Physics, Department of Theoretical Physics, Royal Institute of Technology KTH, AlbaNova University Center, Stockholm, Sweden
    Biophys J 97:2754-60. 2009
    ..As a byproduct, the bending modulus can be calculated from the slope of the compressibility modulus versus system-size. The values obtained in this way for the bending modulus are then in good agreement with experiment...
  66. pmc Large disk intermediate precedes formation of apolipoprotein A-I-dimyristoylphosphatidylcholine small disks
    Keng Zhu
    Department of Cell Biology, Cleveland Clinic, Ohio 44195, USA
    Biochemistry 46:6299-307. 2007
    Small approximately 8.5 nm disks formed spontaneously when dimyristoylphosphatidylcholine (DMPC) large unilamellar vesicles (LUVs) were incubated with apolipoprotein A-I (apoA-I) (100:1 molar ratio)...
  67. ncbi Hydration and temperature dependence of 13C and 1H NMR spectra of the DMPC phospholipid membrane and complete resonance assignment of its crystalline state
    Kaoru Nomura
    Suntory Foundation for Life Sciences, Bioorganic Research Institute, Mishima gun, Osaka, Japan
    J Phys Chem B 115:14991-5001. 2011
    ....
  68. ncbi Subgel studies of dimyristoylphosphatidylcholine bilayers
    Henry H Chang
    Department of Chemistry, Occidental College, Los Angeles, California 90041, USA
    J Phys Chem B 110:22192-6. 2006
    ..However, the subgel (Lc) phase and the corresponding subtransition (Lc--> Lbeta') for dimyristoylphosphatidylcholine (DMPC) has not been clearly characterized...
  69. pmc Lateral diffusion of cholesterol and dimyristoylphosphatidylcholine in a lipid bilayer measured by pulsed field gradient NMR spectroscopy
    Greger Orädd
    Department of Biophysical Chemistry, Umea University, SE 901 87 Umea, Sweden
    Biophys J 83:2702-4. 2002
    ..cholesterol, fluorine labeled at the 6-position, for an oriented lamellar liquid-crystalline phase of dimyristoylphosphatidylcholine (DMPC)/cholesterol/water...
  70. ncbi Conformations, orientations and time scales characterising dimyristoylphosphatidylcholine bilayer membrane. Molecular dynamics simulation studies
    M Pasenkiewicz-Gierula
    Department of Biophysics, Institute of Molecular Biology, Jagiellonian University, Cracow, Poland
    Acta Biochim Pol 44:607-24. 1997
    The results of molecular dynamics simulation of fully hydrated dimyristoylphosphatidylcholine (DMPC) bilayer membrane in the liquid-crystalline phase are presented...
  71. pmc Molecular dynamics simulation of the structure of dimyristoylphosphatidylcholine bilayers with cholesterol, ergosterol, and lanosterol
    A M Smondyrev
    Department of Chemistry, University of North Carolina at Chapel Hill, 27599 USA
    Biophys J 80:1649-58. 2001
    ..The observed differences in simulations with cholesterol and lanosterol may have their implication on the form of the phospholipid/sterol phase diagram...
  72. ncbi Temperature and cholesterol composition-dependent behavior of 1-myristoyl-2-[12-[(5-dimethylamino-1-naphthalenesulfonyl)amino]dodecanoyl]-sn-glycero-3-phosphocholine in 1,2-dimyristoyl-sn-glycero-3-phosphocholine membranes
    Gregory M Troup
    Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    Chem Phys Lipids 131:167-82. 2004
    ..30 and 0.60 at 30 degrees C in DMPC MLV...
  73. pmc Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths
    Michelle E Weber
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Am Chem Soc 127:636-42. 2005
    ..Peak activity was clearly shifted to longer channel lengths upon addition of 20 or 40 mol % cholesterol or n-decane to the liposome preparation...
  74. pmc Reinvestigation by phosphorus NMR of lipid distribution in bicelles
    Mohamed N Triba
    Unité Mixte de Recherche No 7099, Centre National de la Recherche Scientifique, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France
    Biophys J 88:1887-901. 2005
    ....
  75. ncbi Visualization and analysis of apolipoprotein A-I interaction with binary phospholipid bilayers
    M Alejandra Tricerri
    Instituto de Investigaciones Bioquimicas, Consejo Nacional de Investigaciones Cientificas y Technológicas Universidad Nacional de La Plata, La Plata, Argentina, 1900
    J Lipid Res 46:669-78. 2005
    ..We analyzed here apoA-I interaction with dimyristoylphosphatidylcholine/distearoylphosphatidylcholine (DMPC/DSPC) bilayers at a temperature showing phase coexistence...
  76. ncbi Phospholipid morphologies on photochemically patterned silane monolayers
    Michael C Howland
    Department of Applied Science, University of California, Davis, CA 95616, USA
    J Am Chem Soc 127:6752-65. 2005
    ..We also envisage the use of this construct where two-dimensionally fluid, low-defect lipid layers serve as sacrificial resists for the deposition of protein and other material patterns...
  77. pmc Cooperativity and kinetics of phase transitions in nanopore-confined bilayers studied by differential scanning calorimetry
    Ali M Alaouie
    Biophys J 88:L11-3. 2005
    ....
  78. pmc The effect of ergosterol on dipalmitoylphosphatidylcholine bilayers: a deuterium NMR and calorimetric study
    Ya Wei Hsueh
    Department of Physics, Simon Fraser University, Burnaby, British Columbia, Canada, V5A 1S6
    Biophys J 88:1799-808. 2005
    ..The DPPC-ergosterol phase diagram is similar to that of the DPPC-cholesterol multibilayer system except that the so+lo and ld+lo phase coexistence regions are considerably broader...
  79. ncbi Effects of small neutral molecules on phospholipid bicelle ordering
    Xiaoxia Li
    Langmuir 20:8437-41. 2004
    ..Other model dopants (e.g., tetrahydrofuran and benzene) yielded smaller effects. Additionally, the variable bicelle alignment permitted the characterization of the ordering of chloroform molecules within the lipid phase...
  80. ncbi Collective dynamics of lipid membranes studied by inelastic neutron scattering
    M C Rheinstädter
    Institut Laue Langevin, 6 rue Jules Horowitz, BP 156, 38042 Grenoble Cedex 9, France
    Phys Rev Lett 93:108107. 2004
    ..Finally, we can clearly identify an additional nondispersive (optical) mode predicted by molecular dynamics simulations [Phys. Rev. Lett. 87, 238101 (2001)]]...
  81. ncbi Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers
    Almut Mecke
    Department of Physics, University of Michigan, 500 E University Avenue, Ann Arbor, MI 48109, USA
    Chem Phys Lipids 132:3-14. 2004
    ..The fact that tectodendrimers behave differently suggests that their cluster-like architecture plays an important role in their interaction with the lipid bilayer...
  82. pmc Lipid-protein interactions of integral membrane proteins: a comparative simulation study
    Sundeep S Deol
    Department of Biochemistry, and Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, United Kingdom
    Biophys J 87:3737-49. 2004
    ..Overall, these simulations present a dynamic picture of lipid-protein interactions: there are a number of more specific interactions but even these fluctuate on an approximately 1- to 5-ns timescale...
  83. pmc Structural calorimetry of main transition of supported DMPC bilayers by temperature-controlled AFM
    O Enders
    Institute of Biophysics, University Hannover, Hannover, Germany
    Biophys J 87:2522-31. 2004
    ..calorimetry of the transition from the fluid (Lalpha)- to the gel (Pbeta')-phase of supported dimyristoylphosphatidylcholine bilayers...
  84. pmc Anomalous diffusion in a gel-fluid lipid environment: a combined solid-state NMR and obstructed random-walk perspective
    Alexandre Arnold
    Departement de Chimie, Centre de Recherche en Sciences et Ingénierie des Macromolécules, Universite Laval, Quebec, Canada
    Biophys J 87:2456-69. 2004
    ..The method could also be applied to the study of membrane protein lateral diffusion in model membranes...
  85. ncbi Solid-supported lipid multilayers: structure factor and fluctuations
    D Constantin
    Institut fur Rontgenphysik, Geiststrasse 11, 37073 Gottingen, Germany
    Eur Phys J E Soft Matter 12:283-90. 2003
    ..We compare our model to previously existing theories...
  86. ncbi Finite-size effects in biomimetic smectic films
    T A Harroun
    Steacie Institute for Molecular Sciences, National Research Council, Chalk River, Ontario, Canada K0J 1J0
    Phys Rev E Stat Nonlin Soft Matter Phys 70:062902. 2004
    ..Various scenarios that may be responsible for this counterintuitive observation are discussed...
  87. ncbi Surface planar bilayers of phospholipids used in protein membrane reconstitution: an atomic force microscopy study
    Oscar Domenech
    Departament de Quimica Fisica, UB E 08028 Barcelona, Spain
    Colloids Surf B Biointerfaces 47:102-6. 2006
    ..Separated domains were observed in the SPBs of the POPE:POPG mixture and the E. coli lipid extract. The implication of those domains for the correct insertion of membrane proteins into proteoliposomes is discussed...
  88. ncbi Characterization of lipophilic gemcitabine prodrug-liposomal membrane interaction by differential scanning calorimetry
    Francesco Castelli
    Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, V le Andrea Doria, 6, 95125 Catania, Italy
    Mol Pharm 3:737-44. 2006
    ..scanning calorimetry technique, and compared the interaction of pure gemcitabine and its prodrugs with dimyristoylphosphatidylcholine and distearoylphosphatidylcholine vesicles with the aim of demonstrating if the gemcitabine prodrug is ..
  89. ncbi Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis
    Elvis K Tiburu
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Biochim Biophys Acta 1768:2049-59. 2007
    ..The unusual effect of CP-55,940 was present only in bicelles composed of DMPC. These studies strongly suggest that cannabinoid action on the membrane depends upon membrane composition as well as the structure of the cannabinoid ligands...
  90. ncbi Membrane topology of a 14-mer model amphipathic peptide: a solid-state NMR spectroscopy study
    Marise Ouellet
    Departement de Chimie, Centre de Recherche sur la Fonction, la Structure et l Ingénierie des Protéines, Centre de Recherche en Sciences et Ingénierie des Macromolécules, Universite Laval, Quebec, Quebec, Canada G1K 7P4
    Biochemistry 46:6597-606. 2007
    ..peptide in interaction with mechanically oriented bilayers of dilauroylphosphatidylcholine (DLPC), dimyristoylphosphatidylcholine (DMPC), and dipalmitoylphosphatidylcholine (DPPC)...
  91. ncbi The cytoplasmic domains of phospholamban and phospholemman associate with phospholipid membrane surfaces
    Jonathan C Clayton
    Faculty of Life Sciences, University of Manchester, P O Box 88, Sackville Street, Manchester M60 1QD, UK
    Biochemistry 44:17016-26. 2005
    ....
  92. ncbi Lipid-ethanol interaction studied by NMR on bicelles
    Bernd W Koenig
    Structural Biology Institute, IBI 2, Research Center Julich, D 52425 Julich, Germany
    J Phys Chem B 109:7540-7. 2005
    ..Free and bound ethanol are in rapid exchange. The lifetime of ethanol association with phosphatidylcholine membranes is of the order of a few nanoseconds...
  93. pmc Swelling of phospholipids by monovalent salt
    Horia I Petrache
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 0924, USA
    J Lipid Res 47:302-9. 2006
    ..By weakening van der Waals attractions, salt increases energy barriers to membrane contact, possibly affecting cellular communication and biological signaling...
  94. ncbi Electric field unbinding of solid-supported lipid multilayers
    D Constantin
    Institut fur Rontgenphysik, Geiststrasse 11, 37073, Gottingen, Germany
    Eur Phys J E Soft Matter 18:273-8. 2005
    ..We also performed a time-resolved analysis of the intensity of the first Bragg peak and characterized the final state of the sample...
  95. pmc Morphological behavior of lipid bilayers induced by melittin near the phase transition temperature
    Shuichi Toraya
    Graduate School of Engineering, Yokohama National University, Yokohama 240 8501, Japan
    Biophys J 89:3214-22. 2005
    ..On the other hand, additional large amplitude motion induced by melittin at a temperature near the Tc breaks down the magnetic alignment...
  96. ncbi The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I
    John B Massey
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Biochemistry 44:10423-33. 2005
    ..Compared to cholesterol, 7-ketocholesterol can differentially modulate membrane properties involved in protein-membrane association and function...
  97. ncbi Surface thermodynamic properties of monolayers versus reconstitution of a membrane protein in solid-supported bilayers
    Sandra Merino
    Departament de Fisicoquimica, Facultat de Farmacia, Universitat de Barcelona, 08028 Barcelona, Spain
    Colloids Surf B Biointerfaces 44:93-8. 2005
    ..5:0.5, mol/mol), self-assembled structures that remained firmly adsorbed onto the mica surface were observed. These sheets had an irregular shape and their upper layer was more corrugated than that obtained for the phospholipid matrix...
  98. ncbi Observation of the main phase transition of dinervonoylphosphocholine giant liposomes by fluorescence microscopy
    Antti J Metso
    Helsinki Biophysics and Biomembrane Group, Institute of Biomedicine, University of Helsinki, Finland
    Biochim Biophys Acta 1713:83-91. 2005
    ..This at least macroscopically homogenous intermediate phase would then transform into the liquid crystalline state by a second-order process, with further increase in acyl chain trans-->gauche isomerization...
  99. pmc Main phase transitions in supported lipid single-bilayer
    A Charrier
    Centre de Recherche en Matière Condensée et Nanosciences, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Marseille, France
    Biophys J 89:1094-101. 2005
    ..The experimental data can be fit with such a model using known thermodynamic parameters...
  100. ncbi Electron density mapping of triblock copolymers associated with model biomembranes: insights into conformational states and effect on bilayer structure
    Byeongdu Lee
    X ray Science Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA
    Biomacromolecules 9:1541-50. 2008
    ....
  101. ncbi Quantification of lipid bilayer effective microviscosity and fluidity effect induced by propofol
    Mohamed A Bahri
    Laboratory of Experimental Medical Imaging, Liege, Belgium Department of Physics, Institute of Physics, B5, University of Liege, Sart Tilman, B 4000, Liege, Belgium
    Biophys Chem 114:53-61. 2005
    ..8, 16.95, and 27.7 A) amounted 260.21, 123.87, and 102.27 cP, respectively. The concentration 10(-2) M was identified as the saturation limit of propofol in dimyristoyl-l-alpha phosphatidylcholine liposomes...

Research Grants34

  1. Development of Biomedical EPR Instrumentation
    James S Hyde; Fiscal Year: 2013
    ..in a significant biomedical application: the study of cholesterol-mediated lipid interactions using dimyristoylphosphatidylcholine (DMPC) membranes containing cholesterol across the phase diagram...
  2. A Structural/Functional Study on Cholesterol's Regulation of Alzheimer's Disease
    Paul J Barrett; Fiscal Year: 2013
    ..Taken in conjunction with our structural studies, this novel information will open a new avenue for potential AD therapeutics via regulation of the interaction between APP, C99, and cholesterol. ..
  3. CYTOCHROME P450 SUBSTRATE SITING AND MOTION
    Ann McDermott; Fiscal Year: 2002
    ..Studies involving microbial detoxification enzymes with similar chemical mechanisms are also planned. ..
  4. CHAIN DYNAMICS IN LIPID BILAYERS AND MICELLES
    MICHAEL FUSON; Fiscal Year: 1991
    ..3) Multiple quantum relaxation. Triple quantum filtered NOESY experiments show "forbidden" cross peaks, arising from cross-correlation effects...
  5. APOLIPOPROTEIN E AND A 1 LIPID COMPLEX STRUCTURES
    Karl Weisgraber; Fiscal Year: 2003
    ..1. The structures of apoE-dimyristoylphosphatidylcholine (DMPC) complexes will be determined to ascertain how lipid association influences apoE function. 2...
  6. IMMUNE RESPONSES TO MEMBRANES: PHYSICOCHEMICAL STUDIES
    GILLIAN HUMPHRIES; Fiscal Year: 1980
    ..of hapten is approximately l mol percent with respect to the other liposomal lipids, cholesterol and dimyristoylphosphatidylcholine (DMPC)...
  7. Purchase of a 500 MHz Solid State NMR Spectrometer
    Ayyalusamy Ramamoorthy; Fiscal Year: 2007
    ..unreadable] [unreadable] All the major users of the instrument are supported by NIH R01 grants. [unreadable] [unreadable] [unreadable]..
  8. Structure and function of antimicrobial peptides
    Ayyalusamy Ramamoorthy; Fiscal Year: 2008
    ..These peptides have therapeutic potential as antibiotics and have particular importance for cystic fibrosis patients. ..
  9. Controlled Drug Delivery to Colon Tumors Via Ultrasound
    WILLIAM PITT; Fiscal Year: 2006
    ..The research outcomes will prove hypotheses, which will become the basis for understanding and exploiting this therapy in the treatment of localized cancers, hopefully paving the way for clinical application. ..
  10. NMR of basic-aromatic clusters
    Steven Smith; Fiscal Year: 2007
    ..The NMR measurements proposed will provide high resolution detail which is not available from crystallographic methods or more traditional solution NMR methods. [unreadable] [unreadable]..
  11. ATOMIC FORCE MICROSCOPE
    Steven Smith; Fiscal Year: 2005
    ..The research that will be supported by the instrument falls into three general areas: protein-DNA interactions, amyloid formation and inhibition, and membrane protein complexes and arrays. ..
  12. Combined Chemoprevention Using a Nanotechnology-based Therapeutic System
    Sunil Prabhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Computational Facility for Structural Biology
    Steven Smith; Fiscal Year: 2004
    ..abstract_text> ..
  14. ANESTHETIC SITES IN TRANSMEMBRANE PEPTIDES BY NMR
    Pei Tang; Fiscal Year: 2008
    ..The results of this investigation will lead to a new paradigm for the analysis and interpretation of general anesthetic action on neuronal proteins. ..
  15. Directed Proteomics of Alzheimer's Related Proteins
    ELIZABETH KOMIVES; Fiscal Year: 2008
    ..4) Quantitative proteomics (ICAT) will be applied to age-correlated, AD and healthy brain lysates to develop a correlation between amounts of APP and LRP 1-protein interaction complexes and Abeta production. ..
  16. Membrane Mediated Amyloidogenesis
    PAUL AXELSEN; Fiscal Year: 2008
    ..The chief technologies to be employed are a form of internal reflection infrared spectroscopy developed in and unique to this lab, quantitative mass spectrometry, and sequencing mass spectrometry. ..
  17. Structure and Function of Apolipoproteins
    JOSE SOULAGES; Fiscal Year: 2007
    ..This includes understanding of the role of apolipoproteins in the metabolism of lipids and related pathologies, such as atherosclerosis, but it could also involve other kind of pathologies, such as Alzheimer's disease. ..
  18. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  19. Membrane Mediated Amyloidogenesis
    PAUL AXELSEN; Fiscal Year: 2006
    ..In this way, the concept of membrane-mediated amyloidogenesis will be developed on a molecular and pathologically-relevant level. ..
  20. Regulation of Kv3.1 by MiRPs in Auditory Neurons
    GEOFFREY ABBOTT; Fiscal Year: 2006
    ..1 alpha subunits. 3. Examine the predicted effects in auditory neurons of MiRP modulation of Kv3.1, Kv3.3 and Kv3.1-Kv3.3 channels using a combination of heterologous coexpression experiments and computer simulations. ..
  21. Structure and Affinity: Computing FABP-Lipid Selectivity
    Thomas Woolf; Fiscal Year: 2006
    ..The achievement of this goal would have implications for rational treatment of heart disease and other, e.g. digestive system related, human diseases that involve the control of free fatty acid levels. ..
  22. Neonatal Nutrition and the Genetics of Human Lactation
    Richard Weinberg; Fiscal Year: 2003
    ..This knowledge could eventually enable the identification of women who require specific fatty acid or vitamin supplementation to assure optimal infant nutrition. ..
  23. BIOPHYSICAL STUDIES OF LRP LIGANDS INTERACTIONS
    ELIZABETH KOMIVES; Fiscal Year: 2003
    ..In particular, we will probe the role of hepara sulfate proteoglycans in the reaction. (5) Determine the structures of minimal fragments of LRP ligands bound to minimal fragments of the LRP extracellular domain. ..
  24. STRUCTURE-BASED ANTIMICROBIAL DESIGN
    PAUL AXELSEN; Fiscal Year: 2004
    ..The overall aim is to confront the emerging health threat of vancomycin-resistance by facilitating the rational design of drugs, and gain insight into the physico-chemical basis of specific molecular recognition. ..
  25. Arg199: key player in electron transfer in NOS enzyme
    Valentin Gogonea; Fiscal Year: 2004
    ..Primary focus is placed on how Arg199 modulates the electron transfer in NOS a role only revealed during the dynamics of the system. ..
  26. Processing and maturation of high-density lipoproteins
    PAUL AXELSEN; Fiscal Year: 2004
    ..abstract_text> ..
  27. Acquisition of an MALDI TOF-TOF Mass Spectrometer
    ELIZABETH KOMIVES; Fiscal Year: 2005
    ..For this project, the MALDI-TOF-TOF will enable measurements of amide deuteration down to the single amino acid level. ..
  28. CLINICAL TRIALS UNIT
    MAYER DAVIDSON; Fiscal Year: 2003
    ....
  29. Lipid-induced conformational switch of apolipophorin III
    PAUL WEERS; Fiscal Year: 2004
    ..This would allow visualization of individual helices, thereby gaining insight in the helix arrangement of the apolipoprotein on the lipid surface. ..
  30. 2D Nano-flow Mass Spectrometry System
    ELIZABETH KOMIVES; Fiscal Year: 2006
    ..Hook and D. T. O'Connor will analyze the biosynthesis of bioactive peptides. Professor R. Tsien will explore the possibilities of using ReAsH reagents to discover proteins in close proximity in the cell. [unreadable] [unreadable]..
  31. MECHANISM OF ION TRANSPORT THROUGH MEMBRANE CHANNELS
    Roger Koeppe; Fiscal Year: 2001
    ..The proposed investigations of the gramicidin family of channels are aimed at further understanding of general principles that govern structure-function relationships for ion-selective membrane channels. ..
  32. Effects of Statins on AD beyond Cholesterol and Amyloid
    Ling Li; Fiscal Year: 2006
    ..abstract_text> ..
  33. STICS: Surface-Tethered Iterative Carbohydrate Synthesis
    Keith Stine; Fiscal Year: 2007
    ..In order to study the ultimate medical significance of these carbohydrates, new approaches are needed to synthesize them and study their behavior. [unreadable] [unreadable] [unreadable]..
  34. INTERFACIAL ACTIVATION OF WATER SOLUBLE PHOSPHOLIPASES
    Mary Roberts; Fiscal Year: 2003
    ..abstract_text> ..