Summary: Glycoproteins which have a very high polysaccharide content.

Top Publications

  1. pmc Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans
    Renato V Iozzo
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    FEBS J 277:3864-75. 2010
  2. ncbi Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Methods 30:256-68. 2003
  3. ncbi Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
    Achilleas D Theocharis
    Department of Chemistry, University of Patras, Patras, Greece
    FEBS J 277:3904-23. 2010
  4. pmc Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
    Renato V Iozzo
    Department of Pathology, Anatomy and Cell Biology, and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Mol Med 15:1013-31. 2011
  5. ncbi Matrigel: basement membrane matrix with biological activity
    Hynda K Kleinman
    NIH, NIDCR, 30 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892 4370, USA
    Semin Cancer Biol 15:378-86. 2005
  6. ncbi Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
    Akiko Nishiyama
    Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Storrs, Connecticut 06269 3156, USA
    Nat Rev Neurosci 10:9-22. 2009
  7. ncbi NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS
    Mary R L Dawson
    Department of Neuroinflammation, Imperial College London, Charing Cross Hospital Campus, UK
    Mol Cell Neurosci 24:476-88. 2003
  8. pmc PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
    Leanne E Rivers
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:1392-401. 2008
  9. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
  10. pmc Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta
    A Hildebrand
    Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037
    Biochem J 302:527-34. 1994

Detail Information

Publications308 found, 100 shown here

  1. pmc Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans
    Renato V Iozzo
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    FEBS J 277:3864-75. 2010
    The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease...
  2. ncbi Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Methods 30:256-68. 2003
  3. ncbi Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
    Achilleas D Theocharis
    Department of Chemistry, University of Patras, Patras, Greece
    FEBS J 277:3904-23. 2010
    The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment, is markedly altered during malignant transformation and tumor progression...
  4. pmc Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
    Renato V Iozzo
    Department of Pathology, Anatomy and Cell Biology, and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Mol Med 15:1013-31. 2011
    b>Proteoglycans, key molecular effectors of cell surface and pericellular microenvironments, perform multiple functions in cancer and angiogenesis by virtue of their polyhedric nature and their ability to interact with both ligands and ..
  5. ncbi Matrigel: basement membrane matrix with biological activity
    Hynda K Kleinman
    NIH, NIDCR, 30 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892 4370, USA
    Semin Cancer Biol 15:378-86. 2005
    ..In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth...
  6. ncbi Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
    Akiko Nishiyama
    Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Storrs, Connecticut 06269 3156, USA
    Nat Rev Neurosci 10:9-22. 2009
    ..This Review highlights recent findings and unresolved questions related to the lineage and function of polydendrocytes in the CNS...
  7. ncbi NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS
    Mary R L Dawson
    Department of Neuroinflammation, Imperial College London, Charing Cross Hospital Campus, UK
    Mol Cell Neurosci 24:476-88. 2003
  8. pmc PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
    Leanne E Rivers
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:1392-401. 2008
    ..We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb...
  9. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
    Decorin is a member of the expanding group of widely distributed small leucine-rich proteoglycans that are expected to play important functions in tissue assembly...
  10. pmc Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta
    A Hildebrand
    Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037
    Biochem J 302:527-34. 1994
    We have analysed the interactions of three proteoglycans of the decorin family, decorin, biglycan and fibromodulin, with transforming growth factor beta (TGF-beta)...
  11. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
    ..Additional insight into these and other aspects of vascular morphogenesis should be possible through use of NG2 as a mural cell marker...
  12. ncbi Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via alphavbeta5 integrin
    Stefan R Braam
    Leiden University Medical Centre, Postal Zone S 1 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Stem Cells 26:2257-65. 2008
    ..Recombinant vitronectin was the only defined functional alternative to Matrigel, supporting sustained self-renewal and pluripotency in three independent hESC lines...
  13. pmc Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans
    Joan C Marini
    Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    Hum Mutat 28:209-21. 2007
    ..Our data on genotype-phenotype relationships indicate that the two collagen chains play very different roles in matrix integrity and that phenotype depends on intracellular and extracellular events...
  14. pmc Vesicular release of glutamate from unmyelinated axons in white matter
    Jennifer L Ziskin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe St, WBSB 813, Baltimore, Maryland 21205, USA
    Nat Neurosci 10:321-30. 2007
    ..This activity-dependent secretion of glutamate was prevalent in the developing and mature mouse corpus callosum, indicating that axons within white matter both conduct action potentials and engage in rapid neuron-glia communication...
  15. ncbi Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory
    Marko Kaksonen
    Laboratory of Molecular Neurobiology, Institute of Biotechnology, Department of Biosciences, University of Helsinki, Finland
    Mol Cell Neurosci 21:158-72. 2002
    ..We suggest that syndecan-3 acts as an important modulator of synaptic plasticity that influences hippocampus-dependent memory...
  16. ncbi The NG2 proteoglycan: past insights and future prospects
    William B Stallcup
    The Burnham Institute, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurocytol 31:423-35. 2002
    ..This research suggests that interaction of NG2 with extracellular and intracellular ligands regulates signaling events that are important for both cell proliferation and cell migration...
  17. ncbi Proteoglycans in health and disease: the multiple roles of syndecan shedding
    Tina Manon-Jensen
    Deparment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    FEBS J 277:3876-89. 2010
    ..The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other ..
  18. pmc Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
    Weihong Yin
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 284:31972-81. 2009
  19. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
    ..These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis...
  20. ncbi Extracellular matrix proteoglycans control the fate of bone marrow stromal cells
    Yanming Bi
    Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Biol Chem 280:30481-9. 2005
    Extracellular matrix glycoproteins and proteoglycans bind a variety of growth factors and cytokines thereby regulating matrix assembly as well as bone formation...
  21. pmc The type III TGF-beta receptor suppresses breast cancer progression
    Mei Dong
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 117:206-17. 2007
    ..Our results indicate that loss of TbetaRIII through allelic imbalance is a frequent genetic event during human breast cancer development that increases metastatic potential...
  22. ncbi Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers
    Gillian M Beattie
    Department of Pediatrics, Whittier Institute, 9894 Genesee Ave, La Jolla, CA 92037, USA
    Stem Cells 23:489-95. 2005
    ..hESCs retained both normal karyotype and markers of undifferentiated cells, including Oct-4, nanog, and TRA-1-60 and remained pluripotent, as shown by the in vivo formation of teratomas...
  23. pmc The molecular basis of corneal transparency
    John R Hassell
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612 4799, USA
    Exp Eye Res 91:326-35. 2010
    ..of the corneal stroma consists primarily of collagen type I with lesser amounts of collagen type V and four proteoglycans: three with keratan sulfate chains; lumican, keratocan, osteoglycin and one with a chondroitin sulfate chain; ..
  24. ncbi Matrix proteoglycans: from molecular design to cellular function
    R V Iozzo
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
    Annu Rev Biochem 67:609-52. 1998
    ..b>Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as ..
  25. ncbi High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis
    Mattia Barbareschi
    Department of Pathology, Santa Chiara Hospital, Trento, Italy
    Cancer 98:474-83. 2003
    ..Syndecan-1 is a transmembrane heparan sulphate proteoglycan that is involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling...
  26. ncbi Feeder-free growth of undifferentiated human embryonic stem cells
    C Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA
    Nat Biotechnol 19:971-4. 2001
    ..Thus, the cells retain fundamental characteristics of hES cells in this culture system and are suitable for scaleup production...
  27. ncbi Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
    T Xu
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:78-82. 1998
    ..These mice may serve as an animal model to study the role of ECM proteins in osteoporosis...
  28. pmc NG2 cells are distinct from neurogenic cells in the postnatal mouse subventricular zone
    Mila Komitova
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269 3156, USA
    J Comp Neurol 512:702-16. 2009
    ..Our findings indicate that NG2 cells do not represent neuronal progenitor cells in the postnatal SVZ but are likely to be oligodendrocyte precursor cells...
  29. ncbi Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Nat Cell Biol 5:711-9. 2003
    ..Combined blockade of extracellular proteases and ROCK negates the ability of tumour cells to switch between modes of motility and synergises to prevent tumour cell invasion...
  30. pmc Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking
    Yuntao Zhang
    Division of Biology, Kansas State University, Manhattan, Kansas 66506 4901, USA
    J Biol Chem 286:13011-22. 2011
    ..The stroma contains keratocan, lumican, mimecan, and decorin, core proteins of major proteoglycans (PGs) that bind collagen fibrils, playing important roles in stromal transparency...
  31. pmc Perlecan maintains the integrity of cartilage and some basement membranes
    M Costell
    Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
    J Cell Biol 147:1109-22. 1999
  32. ncbi Defective proteoglycan sulfation of the growth plate zones causes reduced chondrocyte proliferation via an altered Indian hedgehog signalling
    Benedetta Gualeni
    Department of Biochemistry Alessandro Castellani, University of Pavia, Pavia, Italy
    Matrix Biol 29:453-60. 2010
    ..These data suggest that in dtd mice proteoglycan undersulfation causes reduced chondrocyte proliferation in the proliferative zone via the Indian hedgehog pathway, therefore contributing to reduced long bone growth...
  33. ncbi The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes
    Justin R Siebert
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, USA
    J Neurochem 119:176-88. 2011
    ..It is primarily composed of chondroitin sulfate proteoglycans (CSPGs) that can inhibit axonal sprouting and regeneration...
  34. ncbi A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice
    Karl J Jepsen
    Department of Orthopedics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:35532-40. 2002
    ..Here, we show that mice deficient in both of these proteoglycans manifest several clinical features of Ehlers-Danlos syndrome...
  35. ncbi Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging
    Miika T Nieminen
    Department of Anatomy, University of Kuopio, Finland
    Magn Reson Med 48:640-8. 2002
    ..understood to accumulate in tissue inversely to the negative charge of cartilage glycosaminoglycans (GAGs) of proteoglycans (PGs), and this leads to a decrease in the T(1) relaxation time of tissue relative to the charge in tissue...
  36. ncbi Negative regulation of transforming growth factor-beta by the proteoglycan decorin
    Y Yamaguchi
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037
    Nature 346:281-4. 1990
    ..Similar repeats have been found in two other proteoglycans, biglycan and fibromodulin, and in several other proteins including Drosophila morphogenetic proteins...
  37. pmc NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease
    Richa B Tripathi
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    J Neurosci 30:16383-90. 2010
    ..PDGFRA/NG2 cells generated very few GFAP(+)-reactive astrocytes (1-2% of all YFP(+) cells) or NeuN(+) neurons (<0.02%). Thus, PDGFRA/NG2 cells act predominantly as a reservoir of new oligodendrocytes in the demyelinated spinal cord...
  38. pmc The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly
    Shoujun Chen
    Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33612 4799, USA
    FEBS J 280:2120-37. 2013
    Small leucine-rich proteoglycans (SLRPs) are involved in a variety of biological and pathological processes. This review focuses on their regulatory roles in matrix assembly...
  39. ncbi Ultrastructure of proteoglycans in tissue-engineered cardiovascular structures
    Markus Rothenburger
    Department of Thoracic and Cardiovascular Surgery, University of Muenster, Muenster, Germany
    Tissue Eng 8:1049-56. 2002
    b>Proteoglycans such as versican, decorin, and perlecan are important components of the extracellular matrix in various tissues...
  40. pmc Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells
    Hailing Lu
    Tumor Vaccine Group, Center for Translational Medicine in Women s Health, University of Washington, Seattle, Washington 98109, USA
    Clin Cancer Res 17:67-76. 2011
    ..The current study was undertaken to investigate the mechanism of the antitumor actions of PSK...
  41. ncbi Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice
    Mai A Sarraj
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Biol Reprod 82:153-62. 2010
  42. ncbi Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon
    L Svensson
    Department of Cell and Molecular Biology, University of Lund, P O Box 94, S 221 00 Lund, Sweden
    J Biol Chem 274:9636-47. 1999
    Fibromodulin is a member of a family of connective tissue glycoproteins/proteoglycans containing leucine-rich repeat motifs...
  43. ncbi Expression cloning and characterization of the TGF-beta type III receptor
    X F Wang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 67:797-805. 1991
    ..This indicates that the type III receptor may regulate the ligand-binding ability or surface expression of the type II receptor...
  44. pmc Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis
    Uri Barash
    Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Haifa, Israel
    FEBS J 277:3890-903. 2010
  45. pmc Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse
    Feng Ju Huang
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA
    Dev Biol 344:1035-46. 2010
    ..These findings demonstrate the importance of NG2-dependent pericyte/endothelial cell interaction in the development and maturation of tumor blood vessels, identifying NG2 as a potential target for anti-angiogenic cancer therapy...
  46. ncbi Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development
    Barbara S Mallon
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44120, USA
    J Neurosci 22:876-85. 2002
    ..On the other hand, it is possible that oligodendrocyte progenitor cells remain undifferentiated in cortex until an essential signal is produced in situ to induce differentiation...
  47. ncbi The role of small leucine-rich proteoglycans in collagen fibrillogenesis
    Sebastian Kalamajski
    Lund University, Department of Experimental Medical Science, BMC B12, Lund, Sweden
    Matrix Biol 29:248-53. 2010
    Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices...
  48. ncbi Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness
    N T Bech-Hansen
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Nat Genet 26:319-23. 2000
    ..The role of other SLRP proteins suggests that mutant nyctalopin disrupts developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB...
  49. pmc NG2 cells: Properties, progeny and origin
    Jacqueline Trotter
    Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany
    Brain Res Rev 63:72-82. 2010
    ..The origin, heterogeneity and function of NG2 cells as modulators of the neuronal network are important incompletely resolved questions...
  50. ncbi Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development
    Miriam Ford-Perriss
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Dev Dyn 227:170-84. 2003
    ..The expression of these specific HSPGs within the proliferative zone of the brain suggests that they may be involved in regulation of early brain development, such as FGF-stimulated proliferation...
  51. ncbi Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    Leda Dimou
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Neurosci 28:10434-42. 2008
    ..Thus, our results demonstrate the continuous generation of mature, myelinating oligodendrocytes in the WM, whereas cells in the GM generated mostly postmitotic NG2(+) glia...
  52. ncbi The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteoglycans
    A Jacquet
    Department of Applied Genetics, Institut de Biologie et de Médicine Moléculaires, Universite Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, B 6041 Gosselies, Belgium
    Mol Biochem Parasitol 116:35-44. 2001
    The attachment of Toxoplasma gondii to target cells is mediated by recognition of cellular heparan sulfate proteoglycans (HSPGs)...
  53. ncbi Tissue engineering of stratified articular cartilage from chondrocyte subpopulations
    T J Klein
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Osteoarthritis Cartilage 11:595-602. 2003
    ..Constructs were cultured for 1 or 2 weeks and were assessed for growth, compressive properties, and deposition, and localization of matrix molecules and superficial zone protein (SZP)...
  54. ncbi The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
    M Tsuda
    Department of Biology, Tokyo Metropolitan University, Japan
    Nature 400:276-80. 1999
    ..have shown that responses to Wg require cell-surface heparan sulphate, a glycosaminoglycan component of proteoglycans. These findings suggest that a cell-surface proteoglycan is a component of a Wg/Wnt receptor complex...
  55. ncbi Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A
    Jose R Conejo-Garcia
    Center for Research in Reproduction and Women s Health, University of Pennsylvania Medical Center, BRBII III, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Med 10:950-8. 2004
  56. ncbi Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function
    H Watanabe
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda MD 20892, USA
    J Biochem 124:687-93. 1998
    ..Nanomelia is a useful model to elucidate intracellular trafficking of proteoglycans. Further studies on aggrecan will lead to prophylaxis and treatment of joint destructive diseases such as ..
  57. ncbi Transmembrane signaling proteoglycans
    John R Couchman
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200 Denmark
    Annu Rev Cell Dev Biol 26:89-114. 2010
    Virtually all metazoan cells contain at least one and usually several types of transmembrane proteoglycans. These are varied in protein structure and type of polysaccharide, but the total number of vertebrate genes encoding transmembrane ..
  58. ncbi Proteoglycans: from structural compounds to signaling molecules
    Liliana Schaefer
    Pharmazentrum frankfurt ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Germany
    Cell Tissue Res 339:237-46. 2010 leading to their present classification into three major categories: (1) small leucine-rich proteoglycans, 2) modular proteoglycans, and 3) cell-surface proteoglycans...
  59. ncbi Decorin prevents metastatic spreading of breast cancer
    Charles C Reed
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 24:1104-10. 2005
    ..These results demonstrate a novel role for decorin in reduction or prevention of tumor metastases in this breast cancer model and could eventually lead to improved therapeutics for metastatic breast cancer...
  60. pmc Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury
    Drew L Sellers
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 29:6722-33. 2009
    ..We conclude that NG2 progeny are diverse lineages that obey progressive cues after trauma to replenish the injured niche...
  61. pmc Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan
    Paul G Scott
    Department of Biochemistry and Alberta Synchrotron Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Proc Natl Acad Sci U S A 101:15633-8. 2004
    ..Decorin is the prototype of the family of small leucine-rich repeat proteoglycans and proteins (SLRPs), characterized by a protein core composed of leucine-rich repeats (LRRs), flanked by two ..
  62. ncbi Decorin interacts with fibrillar collagen of embryonic and adult human skin
    R Fleischmajer
    Department of Dermatology, Mount Sinai School of Medicine, New York, New York 10029
    J Struct Biol 106:82-90. 1991
    Biglycan (PG-I, BGN) and decorin (PG-II, DCN) are small proteoglycans that have been isolated in cartilage, skin, and bone...
  63. pmc Shaping morphogen gradients by proteoglycans
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Cold Spring Harb Perspect Biol 1:a002493. 2009
    ..Here, we review these data, highlighting recent findings that reveal mechanistic roles of HSPGs in controlling morphogen gradient formation...
  64. ncbi Proteoglycans in atherosclerosis and restenosis: key roles for versican
    Thomas N Wight
    Department of Vascular Biology, The Hope Heart Institute, 1124 Columbia St, No 783, Seattle, Wash 98104 2046, USA
    Circ Res 94:1158-67. 2004
    ..Collectively, these studies highlight the critical importance of this specific ECM component in atherosclerosis and restenosis...
  65. pmc Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses
    Saeed Shafti-Keramat
    Laboratory of Viral Oncology, Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases DIAID, University of Vienna Medical School, Vienna, Austria
    J Virol 77:13125-35. 2003
    ..Early events of papillomavirus infectivity are poorly understood. While heparan sulfate proteoglycans (HSPGs) mediate initial binding to the cell surface, the class of proteins carrying heparan sulfates has not ..
  66. ncbi Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
    K A Lewis
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 404:411-4. 2000
    ..The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity and function.
  67. pmc Proteoglycans and more--from molecules to biology
    Dick Heinegard
    Department of Clinical Sciences, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Lund, Sweden
    Int J Exp Pathol 90:575-86. 2009 collagen VI molecules assembled to beaded filaments in the matrix catalysed by interactions with small proteoglycans of the LRR-family, which remain bound to the filament providing for interactions via a linker of a matrilin to ..
  68. pmc Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint
    N Kiga
    Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Japan
    Eur J Histochem 55:e11. 2011
    Small leucine-rich repeat proteoglycans (SLRP) are present in the extracellular matrix of the temporomandibular joint (TMJ) disc...
  69. pmc Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neoplasia 11:1042-53. 2009
    ..Those findings highlight the effectiveness of decorin in the presence of a powerful genetic cancer risk and implicate decorin as a potential new agent for prostate cancer therapy by targeting EGFR/AR-PI3K-Akt pathways...
  70. pmc Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release
    K Imai
    Department of Molecular Immunology and Pathology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920, Japan
    Biochem J 322:809-14. 1997
  71. ncbi Proteoglycans in the central nervous system: plasticity, regeneration and their stimulation with chondroitinase ABC
    Jessica C F Kwok
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK
    Restor Neurol Neurosci 26:131-45. 2008
    ..regeneration is inhibited by the presence of the various inhibitory molecules, including chondroitin sulfate proteoglycans (CSPGs) which are upregulated around the injury site...
  72. ncbi The fate of synaptic input to NG2 glial cells: neurons specifically downregulate transmitter release onto differentiating oligodendroglial cells
    Maria Kukley
    Department of Neurosurgery, University Clinic Bonn, D 53105 Bonn, Germany
    J Neurosci 30:8320-31. 2010
  73. pmc Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
    Jian Wang
    Translational Cancer Research Group, Department of Biomedicine, University of Bergen, Bergen, Norway
    PLoS ONE 6:e23062. 2011
    ..Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy...
  74. ncbi Platelet derived growth factor BB is a ligand for dermatan sulfate chain(s) of small matrix proteoglycans from normal and fibrosis affected fascia
    Ewa M Kozma
    Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Jednosci 8, 41 200 Sosnowiec, Poland
    Biochimie 91:1394-404. 2009
    ..We examined by the solid phase assay the growth factor binding to DS chains of small proteoglycans from various fasciae as well as to standard CSs...
  75. ncbi Small leucine-rich proteoglycans, decorin and fibromodulin, are reduced in postburn hypertrophic scar
    Dariush Honardoust
    Wound Healing Research Group, Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Alberta, Edmonton, Alberta, Canada
    Wound Repair Regen 19:368-78. 2011
    Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules that regulate collagen fibrillogenesis and inhibit transforming growth factor-β activity; thus, they may play a critical role in wound healing and scar ..
  76. ncbi The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer
    Ryan S Turley
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 67:1090-8. 2007
  77. ncbi Cell cycle dynamics of NG2 cells in the postnatal and ageing brain
    Konstantina Psachoulia
    Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron Glia Biol 5:57-67. 2009
    ..We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age)...
  78. ncbi Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones
    Jeong Suk Kang
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Mech Dev 121:301-12. 2004
    ..and characterization of a cDNA encoding zebrafish dermacan, a novel member of hyaluronan (HA)-binding proteoglycans, which was termed after its characteristic expression in the zebrafish dermal bones...
  79. ncbi Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia
    Alice Hadchouel
    INSERM, U955, Creteil, France
    Am J Respir Crit Care Med 184:1164-70. 2011
    ..Bronchopulmonary dysplasia is the most common chronic respiratory disease in premature infants. Genetic factors might contribute to bronchopulmonary dysplasia susceptibility...
  80. pmc Axon-glia synapses are highly vulnerable to white matter injury in the developing brain
    Yan Shen
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Neurosci Res 90:105-21. 2012
    ..More broadly, the study of white matter development and injury has general implications for a variety of neurological diseases, including PVL, stroke, spinal cord injury, and multiple sclerosis...
  81. ncbi NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain
    Sameh Geha
    Department of Neuropathology, Sainte Anne Hospital, Paris, France
    Brain Pathol 20:399-411. 2010
    ..These results provide evidence for a persistent gliogenesis in the human cortex and white matter that is enhanced in an epileptic environment...
  82. ncbi SLRP interaction can protect collagen fibrils from cleavage by collagenases
    Yeqing Geng
    Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
    Matrix Biol 25:484-91. 2006
    Decorin, fibromodulin and lumican are small leucine-rich repeat proteoglycans (SLRPs) which interact with the surface of collagen fibrils...
  83. pmc Mice lacking the syndecan-3 gene are resistant to diet-induced obesity
    April D Strader
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 114:1354-60. 2004
    ..Syndecans are a family of membrane-bound heparan sulfate proteoglycans that modulate ligand-receptor interactions...
  84. ncbi Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression
    M V Friedrich
    Max Planck Institut fur Biochemie, Germany
    Eur J Biochem 267:3149-59. 2000
    ..This indicates, as for mammalian species, a distinct role of perlecan during Drosophila development...
  85. pmc An introduction to proteoglycans and their localization
    John R Couchman
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    J Histochem Cytochem 60:885-97. 2012
    b>Proteoglycans comprise a core protein to which one or more glycosaminoglycan chains are covalently attached...
  86. ncbi Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides
    Nicholas T Seyfried
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Biol Chem 280:5435-48. 2005
    ..aggregates (potentially containing new members of the link protein family), in which other chondroitin sulfate proteoglycans (i.e...
  87. pmc Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis
    Maria V Barbolina
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA
    Semin Cell Dev Biol 19:24-33. 2008
    ..This review will utilize membrane type 1 MMP (MT1-MMP) as an example to highlight substrate diversity in pericellular proteolysis catalyzed by a membrane anchored MMP...
  88. pmc Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
    Craig A Cooney
    Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Breast Cancer Res 13:R58. 2011
  89. ncbi Interleukin-1beta selectively decreases the synthesis of versican by arterial smooth muscle cells
    Joan M Lemire
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Cell Biochem 101:753-66. 2007
    b>Proteoglycans accumulate in lesions of atherosclerosis but little is known as to which factors regulate the synthesis of these molecules...
  90. ncbi Comparison of biomaterials and extracellular matrices as a culture platform for multiple, independently derived human embryonic stem cell lines
    Heidi Hakala
    REGEA, Institute for Regenerative Medicine, University of Tampere, Tampere, Finland
    Tissue Eng Part A 15:1775-85. 2009
    ..A long-term, feeder cell-free culture system was successful on Matrigel in combination with mTeSR1 culture medium, but a xeno-free, fully defined, and reproducible feeder cell-free hESC culture method still remains to be developed...
  91. pmc Betaglycan is required for the establishment of nephron endowment in the mouse
    Kenneth A Walker
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e18723. 2011
    ..5 and e14.5. The opposing morphological and molecular phenotypes in betaglycan heterozygote and null mutants demonstrate that the levels of betaglycan must be tightly regulated for optimal kidney development...
  92. pmc Effects of oral glucosamine hydrochloride administration on plasma free amino acid concentrations in dogs
    Kazuo Azuma
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4 101 Koyama Minami, Tottori 680 8553, Japan
    Mar Drugs 9:712-8. 2011
    ..A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs...
  93. ncbi Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity
    Lorna R Fiedler
    Matrix Biology and Tissue Repair Research Unit, School of Dentistry, Cardiff University, Heath Park, Cardiff, United Kingdom CF14 4XY
    J Biol Chem 283:17406-15. 2008
  94. doi Changes in glycosaminoglycans and related proteoglycans in intrinsically aged human skin in vivo
    Jang Hee Oh
    Exp Dermatol 20:454-6. 2011
    Glycosaminoglycans (GAGs) and proteoglycans (PGs) are involved in various structural functions and physiological regulations in the skin...
  95. pmc Decorin modulates collagen matrix assembly and mineralization
    Yoshiyuki Mochida
    Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, United States
    Matrix Biol 28:44-52. 2009
    Decorin (DCN) is one of the major matrix proteoglycans in bone...
  96. pmc Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
    Allan A Young
    Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia
    Arthritis Res Ther 7:R852-61. 2005
    ..evaluate changes in chondrocyte expression of types I, II and III collagen; aggrecan; the small leucine-rich proteoglycans (SLRPs) biglycan, decorin, lumican and fibromodulin; transforming growth factor-beta; and connective tissue ..
  97. ncbi Differential regulation of lubricin/superficial zone protein by transforming growth factor beta/bone morphogenetic protein superfamily members in articular chondrocytes and synoviocytes
    Takahiro Niikura
    University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    Arthritis Rheum 56:2312-21. 2007
    ..To investigate the role of transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) superfamily members on accumulation of superficial zone protein (SZP) in articular chondrocytes and synoviocytes...
  98. ncbi Increased risk of cardiovascular disease in Type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans
    R Mangat
    Alberta Institute for Human Nutrition, Alberta Diabetes Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada
    Diabet Med 28:61-72. 2011
  99. pmc YKL-40, a secreted glycoprotein, promotes tumor angiogenesis
    R Shao
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, USA
    Oncogene 28:4456-68. 2009
    ..These findings provide novel insights into angiogenic activities and molecular mechanisms of YKL-40 in cancer development...
  100. pmc B lymphocytes express and lose syndecan at specific stages of differentiation
    R D Sanderson
    Department of Pediatrics, Stanford University School of Medicine, California 94305
    Cell Regul 1:27-35. 1989
    ..These results indicate that B cells differentiating in vivo alter their matrix receptor expression and suggest a role for syndecan in B cell stage-specific adhesion...
  101. pmc The elastic modulus of Matrigel as determined by atomic force microscopy
    Shauheen S Soofi
    Department of Chemical and Biological Engineering, College of Engineering, University of Wisconsin, Madison, WI 53706, United States
    J Struct Biol 167:216-9. 2009
    ..The reason for this discrepancy is believed to result from differences in test methods and the tendency of Matrigel to soften at temperatures below 37 degrees C...

Research Grants70

  1. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
  2. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..We proposed that collagen X and heparan sulfate proteoglycans, e.g...
    Tibor T Glant; Fiscal Year: 2013
    ..We propose to reduce the size of these regions in the mouse genome, which cannot be done in human population, and select candidate genes that may be involved in arthritis susceptibility and disease severity. ..
  4. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    ..These studies should yield valuable information about the mechanism of aberrant gene expression/ differentiation in BPS/IC bladder cells, potentially leading to development of more effective therapies. ..
  5. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..Because PV neurons are ensheathed by chondroitin sulfate proteoglycans-rich perineuronal nets (PNNs), which are thought to play a crucial role in maintaining their functional ..
  6. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..This work may lead to novel therapy to inhibit the spread, morbidity, and mortality of cancer in our Veteran population. ..
  7. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..Interestingly, two proteoglycans, Lumican and Decorin were increased in the skin of ER?? -/- mice, while their decrease was observed in the ..
  8. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..The specific hypotheses to be tested are: 1) that heparan sulfate proteoglycans (HSPG) modulate the dissociation of fVIII from vWF leading to enhanced uptake of fVIII by LRP/LDLR;2) that we ..
  9. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..circulating lipoprotein levels and can facilitate lipid uptake via their associations with heparin sulphate proteoglycans (HSPG) on hepatocyte surface...
  10. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..A portion of this adhesion activity is attributable to proteoglycans, which consist of glycosaminoglycans linked to core proteins...
  11. Thrombospondin 4 A1
    JOHN W LAWLER; Fiscal Year: 2010
    ..Specific Aim 1. To identify key amino acids for the interactions of COMP with proteins and proteoglycans (PGs). We have found that COMP binds to aggrecan, as well as to integrins in chondrocytes and fibroblasts...
    Douglas M Tollefsen; Fiscal Year: 2010
    ..Heparin cofactor II (HCII) is an inhibitor of thrombin in plasma that can be activated by dermatan sulfate (DS) proteoglycans on vascular smooth muscle cells and fibroblasts...
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..Characterization of these proinflammatory pathways allows for therapeutic approaches based on targeted intervention. ..
    Gary W Conrad; Fiscal Year: 2012
    ..b>Proteoglycans of the LASIK scar interface are abnormal compared with adjacent stroma...
  15. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..This study should not only provide novel insights into the role of DDR2 in the progression of genetic forms of OA, but may shed light on aspects of disease progression in non-genetic forms as well. ..
  16. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..abstract_text> ..
  17. Extracellular Matrix Remodeling During Aging
    JANE M SOTTILE; Fiscal Year: 2010
    ..and turnover of other ECM molecules including collagen I, collagen III, thrombospondin, and heparin sulfate proteoglycans. Further, factors that regulate the polymerization of FN into the ECM regulate the stability and turnover of ..
  18. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..Chrondroitin sulfate proteoglycans (CSPG)-- neuracan, phosphacan, brevican, decorin, NG2 &versican--are important components of the ..
    Jeffrey H Miner; Fiscal Year: 2012
    ..The overall goal of this proposal is to use a mouse model system to investigate whether an abnormal GBM composition can be normalized in patients and whether this will improve and/or prolong kidney function. ..
  20. Role of NOD2 in Inflammatory Arthritis and Innate Immunity
    MICHAEL PATRICK DAVEY; Fiscal Year: 2012
    ..Understanding how NOD2 controls the development of inflammation leading to tissue injury and pathology will have broad implications for the health of veterans. ..
  21. Heparan Sulfate Proteoglycans in Human Hematopoiesis
    Pankaj Gupta; Fiscal Year: 2013
  22. Glypican-1 in gliomagenesis
    Andreas Friedl; Fiscal Year: 2013
    ..The GPC1 signaling pathway may offer opportunities for therapeutic intervention by targeting either GPC1 itself or downstream mediators. ..
  23. Disruption of Extracellular Matrix-Glial Interactions in Schizophrenia
    Sabina Berretta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chondroitin sulfate proteoglycans (CSPGs) are a main component of the brain extracellular matrix (ECM)...
  24. HDAC6: a target for regeneration following injury in the nervous system
    BRETT CAMERON LANGLEY; Fiscal Year: 2013
    ..proteins such as myelin associated-glycoprotein (MAG) and reactive astrocyte-produced chondroitin sulfate proteoglycans (CSPGs)...
  25. DNA Pro-Drug Technology in Localized Wound Healing and Tissue Regeneration
    Arthur A Decarlo; Fiscal Year: 2011
  26. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..This study will investigate the function of recently discovered sulfatase enzymes that enhance growth of liver cancers, with the goal of developing effective treatments for this devastating disease. ..
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..mucosal T lymphocytes are enmeshed in the complex and highly organized network of proteins, glycoproteins, and proteoglycans known as the extracellular matrix (ECM), we propose that the chronicity, exacerbation, and recurrence of IBD ..
  28. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..This proposal will evaluate the ability of a completely noninvasive, quantitative MR technique, performed at clinically relevant field strengths, to assess meniscal repair and function. ..
  29. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..This will be a novel application of neuroregeneration and neurorehabilitation techniques to increase our understanding of the potential for repair after SCI. ..
    Ted S Acott; Fiscal Year: 2012
    ..Our working hypothesis is that the glycosaminoglycans (GAGs) on one or more specific proteoglycans within the juxtacanalicular region of the trabecular meshwork (TM) and Schlemm's canal inner wall ..
  31. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012
    ..The molecular mechanisms that regulate this phenomenon will be identified and a potential therapeutic strategy evaluated. ..
  32. Microcephaly in an RNAi mouse with reduced sulfation
    Nancy B Schwartz; Fiscal Year: 2010
    ..Since smaller brain size is the main phenotype in the proposed transgenic animals, the investigators anticipate that these studies will lead to a better understanding of microcephaly in humans. ..
  33. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..Wharton's jelly (WJ) surrounds the cord vessels and consists of proteoglycans, collagen, hyaluronic acid and fibroblast-like cells...
    Jeffrey D Esko; Fiscal Year: 2010
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various ..
  35. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    ..developmental age of the IPM and removal of molecules inhibitory to neural regeneration (chondroitin sulfate proteoglycans) will be explored as key factors in creating an environment promoting seeded cell migration, integration into ..
  36. ApoE receptor pathways and abeta metabolism
    Guojun Bu; Fiscal Year: 2013
    ..Together, our proposed studies will likely provide insight into the mechanisms underlying A[unreadable] clearance and aggregation pathways in the brain and uncover how apoE isoforms and apoE receptors regulate these events in AD. ..
  37. Metabolic Engineering of Chinese Hamster Ovary Cells for Production of Heparin
    Susan T Sharfstein; Fiscal Year: 2011
    ..heparan sulfate glycosaminoglycan is a less sulfated version of heparin that is attached to core proteins of proteoglycans, ubiquitously found on the external cell membrane of all animal tissues...
  38. Myeloid-derived Suppressor Cells in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2012
  39. Apolipoprotein A-V: A Functional Proteomics Study
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..Evidence indicates apoA-V binds heparan sulfate proteoglycans, low-density lipoprotein receptor family members and the endothelial cell surface protein ..
  40. In utero protein transduction to interrogate inner ear sensory patch formation
    JOHN VINCENT BRIGANDE; Fiscal Year: 2013
    ..of nonconserved residues facilitates endocytosis in part by maximizing productive interactions with sulfated proteoglycans in the glycocalyx...
  41. Screens for novel compounds to correct diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2011
    ..In 1991-1992, seminal work from our laboratory implicated heparan sulfate proteoglycans (HSPGs) in remnant lipoprotein uptake...
  42. Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    Joanna Phillips; Fiscal Year: 2013
    ..including Wnts, VEGF, and FGF-1, by acting on the 6O-sulfation of glucosamine (6OS) on heparan sulfate proteoglycans (HSPGs)...
    Yvonne Kapila; Fiscal Year: 2009
    ..These studies will help explain some of the cell-matrix interactions and signaling mechanisms that regulate tumor cell biology, and may provide insights into the pathogenesis of oral SCC. ..
  44. Macrophage Infiltration of Renal Tissue via beta-3 Integrins and Agrin
    Scott D Blystone; Fiscal Year: 2013
    ..Understanding the mechanism of glomerulonephritis can provide new targets for drugs to reduce the progression of this disease. ..
    Alison Finnegan; Fiscal Year: 2013
    ..These studies aim to develop novel insights into the autoimmune disease process that will facilitate the diagnosis and treatment of RA. ..
  46. 2012 Proteoglycans Gordon Research Conference
    Robert J Linhardt; Fiscal Year: 2012
    ..provided by applicant): The proposal requests partial support for the Gordon Research Conference on Proteoglycans that will be held on July 8-13, 2012 in Proctor Academy, Andover, NH...
    Robert J Linhardt; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Proteoglycans (PGs) play an important role in a variety of diseases affecting the excretory system, respiratory system, circulatory system, skeletal system, also the multisystem diseases of aging and ..
  48. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
    Kendal Broadie; Fiscal Year: 2013
    ..applicant): This research program investigates interactive roles of secreted signals and extracellular matrix proteoglycans in the development of neuromuscular junction (NMJ) synapses...
  50. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    ..We propose to investigate the effectiveness of two small peptides for their anti-viral and anti-inflammatory properties for the treatment of HSK. ..
  51. Extracellular anomalies in Schizophrenia: from molecules to symptoms
    Sabina Berretta; Fiscal Year: 2013
    ..Our data points to anomalous expression of chondroitin sulfate proteoglycans (CSPGs), a main component of the ECM, in glial cells and ECM...
  52. The Role of Biglycan in Reproduction
    ..of the extracellular matrix and which have been implicated in the pathogenesis of PPROM, interact with proteoglycans including biglycan...
  53. Hematopoietic Stem Cell Differentiation to Macrophages
    E Richard Stanley; Fiscal Year: 2013
    ..2. To define and compare the activities, expression patterns and regulation of IL-34 and CSF-1. 3. To establish the biological relationships between IL-34, CSF-1 and the CSF-1 receptor ..
  54. The Endothelial Glycocalyx: Its Structure and Function and as a Mechanotransducer
    John M Tarbell; Fiscal Year: 2013
    ..that line our vasculature are coated with a glycocalyx of membrane-bound macromolecules comprised of sulfated proteoglycans, hyaluronic acid, sialic acids, glycocproteins and plasma proteins that adhere to this surface matrix...
  55. Fibulin-1 Regulation of the DiGeorge Syndrome Pathogenesis Pathway
    WILLIAM SCOTT ARGRAVES; Fiscal Year: 2012
    ..A novel direction for the research stems from our discovery that fibulin-1 regulates the activity of Fgf8, a growth factor implicated as a key component of the pathway that is dysfunctional in DGS. ..
  56. Bioengineered scaffolds for peripheral nerve repair
    Ravi V Bellamkonda; Fiscal Year: 2010 availability, collateral damage at the donor site, and the presence of inhibitory chondroitin sulfate proteoglycans within the grafts...
  57. Functional characterization of a novel gene for non-alcoholic fatty liver disease
    ALEXIS L GORDEN; Fiscal Year: 2011
    ..This research may lead to novel targets and strategies for prevention and treatment of NAFLD. ..
  58. Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 Entry
    Vaibhav Tiwari; Fiscal Year: 2011
    ..HSV envelope glycoproteins, gB and gC, initiate contact with host cells by binding to heparan sulfate (HS) proteoglycans. Subsequently, a third glycoprotein D, (gD), binds to one of its receptors...
  59. Structure-Function Studies &Molecular Interactions of Chemokines
    Tracy M Handel; Fiscal Year: 2013
    ..are structurally diverse linear carbohydrates that are often attached to membrane bound protein anchors as proteoglycans. These interactions are involved in locally sequestering chemokines on cell surfaces, preventing diffusion so ..
  60. New probes for matrix metalloproteinase 13
    Gregg B Fields; Fiscal Year: 2013
    ..The main constituents of articular or joint cartilage are type II collagen and various proteoglycans, such as aggrecan, chondroitin sulfate, and hyaluronan...
  61. Novel Gene Targets for CNS Axonal Regeneration
    Vance P Lemmon; Fiscal Year: 2012
    ..2 candidate genes will be tested using a well-established in vitro assay where neurons are grown on myelin or proteoglycans and the lengths of their neurites measured...
  62. A collagen wound dressing augmented with a proteoglycan mimic to enhance chronic
    Kate Stuart; Fiscal Year: 2013
    ..GMP synthesis, biocompatibility testing, and a small clinical safety study will be the milestones for a Phase II award. ..
    STEVEN KINCAID; Fiscal Year: 1991
    ..The results wil determine the ability of the HA/TGF-B composite to stimulate the synthesis of proteoglycans, and potentially decrease catabolism, by chondrocytes capable of responding to stimuli in vivo...
    LENNART RODEN; Fiscal Year: 1993
    The long-term objective of this project is to elucidate the enzymatic reactions by which xylose-linked proteoglycans are assembled...
  65. Perlecan modulates VEGF Bio-Availability in Human Osteoarthritic Cartilage
    RONALD GOMES; Fiscal Year: 2009
    ..applicant): There is a fundamental gap in understanding how human articular cartilage derived heparan sulfate proteoglycans bind to and modulate the activity of heparin binding growth factors important for regulating cartilage ..
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..the functional roles of neurocan and phosphacan, two major nervous tissue-specific chondroitin sulfate proteoglycans whose biochemical properties and primary structures have previously been described by this laboratory...
    Arnold Caplan; Fiscal Year: 1999
    ..The two Specific Aims focus on our hypothesis that the glycosaminoglycan chains of proteoglycans contain chemical and structural information which affects/controls cartilage extracellular matrix structure ..
    RICHARD MARGOLIS; Fiscal Year: 2001
    We have isolated and biochemically characterized several chondroitin sulfate proteoglycans of brain identified with monoclonal antibodies, and will now extend this work using other available antibodies...
    John Hassell; Fiscal Year: 2003
    ..This matrix consists primarily of collagens I, V, & VI and of proteoglycans bearing keratan sulfate (KS) and chondroitin/dermatan sulfate side chains...
    JOHN COUCHMAN; Fiscal Year: 2001
    ..Basement membrane composition includes collagens, glycoproteins and proteoglycans. Bamacan is a chondroitin sulfate proteoglycan that may regulate basement membrane stability since its ..