Summary: A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.

Top Publications

  1. pmc Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene
    Sheng Teng
    Department of Molecular Plant Physiology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Plant Physiol 139:1840-52. 2005
  2. doi Sucrose efflux mediated by SWEET proteins as a key step for phloem transport
    Li Qing Chen
    Carnegie Institution for Science, 260 Panama Street, Stanford, CA 94305, USA
    Science 335:207-11. 2012
  3. pmc The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 108:5104-9. 2011
  4. pmc Protection of SH-SY5Y neuronal cells from glutamate-induced apoptosis by 3,6'-disinapoyl sucrose, a bioactive compound isolated from Radix Polygala
    Yuan Hu
    Department of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China
    J Biomed Biotechnol 2012:1-5. 2012
  5. pmc Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
    Oliver J Mace
    Department of Biology Area 3, University of York, York YO10 5YW, UK
    J Physiol 582:379-92. 2007
  6. ncbi Effect of sucrose on inflammatory markers in overweight humans
    Lone B Sørensen
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 82:421-7. 2005
  7. pmc Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
    Jemma K Richards
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 199:109-17. 2008
  8. doi Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2
    Alexander Schulz
    University of Wuerzburg, Institute for Molecular Plant Physiology and Biophysics, Julius von Sachs Platz 2, D 97082 Wuerzburg, Germany
    Plant J 68:129-36. 2011
  9. pmc Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake
    Nicole M Avena
    Department of Psychology, Princeton University, Princeton, NJ 08540, USA
    Neurosci Biobehav Rev 32:20-39. 2008
  10. pmc The Arabidopsis plastid-signalling mutant gun1 (genomes uncoupled1) shows altered sensitivity to sucrose and abscisic acid and alterations in early seedling development
    Amanda Cottage
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    J Exp Bot 61:3773-86. 2010

Detail Information

Publications370 found, 100 shown here

  1. pmc Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene
    Sheng Teng
    Department of Molecular Plant Physiology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Plant Physiol 139:1840-52. 2005
    Sugar-induced anthocyanin accumulation has been observed in many plant species. We observed that sucrose (Suc) is the most effective inducer of anthocyanin biosynthesis in Arabidopsis (Arabidopsis thaliana) seedlings...
  2. doi Sucrose efflux mediated by SWEET proteins as a key step for phloem transport
    Li Qing Chen
    Carnegie Institution for Science, 260 Panama Street, Stanford, CA 94305, USA
    Science 335:207-11. 2012
    Plants transport fixed carbon predominantly as sucrose, which is produced in mesophyll cells and imported into phloem cells for translocation throughout the plant...
  3. pmc The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 108:5104-9. 2011
    ..Here we report sensitivity of the Arabidopsis thaliana circadian oscillator to sucrose, providing evidence that plant metabolism can regulate circadian function...
  4. pmc Protection of SH-SY5Y neuronal cells from glutamate-induced apoptosis by 3,6'-disinapoyl sucrose, a bioactive compound isolated from Radix Polygala
    Yuan Hu
    Department of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China
    J Biomed Biotechnol 2012:1-5. 2012
    The neuroprotective effects of 3,6'-disinapoyl sucrose (DISS) from Radix Polygala against glutamate-induced SH-SY5Y neuronal cells injury were evaluated in the present study...
  5. pmc Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
    Oliver J Mace
    Department of Biology Area 3, University of York, York YO10 5YW, UK
    J Physiol 582:379-92. 2007
  6. ncbi Effect of sucrose on inflammatory markers in overweight humans
    Lone B Sørensen
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 82:421-7. 2005
    ..Observational studies have found that dietary glycemic load is positively associated with C-reactive protein (CRP) concentrations in healthy humans, which suggests that the type of carbohydrate ingested influences inflammatory activity...
  7. pmc Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
    Jemma K Richards
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 199:109-17. 2008
    ..In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking.
  8. doi Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2
    Alexander Schulz
    University of Wuerzburg, Institute for Molecular Plant Physiology and Biophysics, Julius von Sachs Platz 2, D 97082 Wuerzburg, Germany
    Plant J 68:129-36. 2011
    ..Some members of the SUC family are plasma membrane proton/sucrose symporters...
  9. pmc Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake
    Nicole M Avena
    Department of Psychology, Princeton University, Princeton, NJ 08540, USA
    Neurosci Biobehav Rev 32:20-39. 2008
    ..The evidence supports the hypothesis that under certain circumstances rats can become sugar dependent. This may translate to some human conditions as suggested by the literature on eating disorders and obesity...
  10. pmc The Arabidopsis plastid-signalling mutant gun1 (genomes uncoupled1) shows altered sensitivity to sucrose and abscisic acid and alterations in early seedling development
    Amanda Cottage
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    J Exp Bot 61:3773-86. 2010
    ..gun1 seedlings accumulated less anthocyanin than wild-type seedlings when grown in the presence of 2% (w/v) sucrose, due to lower amounts of transcripts of early anthocyanin biosynthesis genes in gun1...
  11. doi The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats
    Bianca Jupp
    Florey Neuroscience Institutes, Parkville, Victoria 3010, Australia
    Brain Res 1391:54-9. 2011
    ..schedules of reinforcement, and whether this differs from the motivation to administer a natural food reward, sucrose (0.2-0.7% w/v) in alcohol preferring (iP) rats...
  12. pmc Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression
    Karolina P Skibicka
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden
    Addict Biol 17:95-107. 2012
    ..for natural sugar reward by examining the role of ghrelin receptor (GHS-R1A) stimulation and blockade for sucrose progressive ratio operant conditioning, a procedure used to measure motivational drive to obtain a reward...
  13. doi The sucrose transporter family in Populus: the importance of a tonoplast PtaSUT4 to biomass and carbon partitioning
    Raja S Payyavula
    School of Forest Resources and Environmental Sciences, Michigan Technological University, Houghton, MI 49931, USA
    Plant J 65:757-70. 2011
    Plasma membrane, proton-coupled Group II sucrose symporters (SUT) mediate apoplastic phloem loading and sucrose efflux from source leaves in Arabidopsis and agricultural crop species that have been studied to date...
  14. ncbi MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes
    Oliver Thimm
    Max Planck Institute for Molecular Plant Physiology, Golm, Germany
    Plant J 37:914-39. 2004
  15. pmc Sucrose utilization in budding yeast as a model for the origin of undifferentiated multicellularity
    John H Koschwanez
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 9:e1001122. 2011
    ..Yeast cells can cooperate by secreting invertase, an enzyme that digests sucrose into monosaccharides, and many wild isolates are multicellular because cell walls remain attached to each other ..
  16. pmc Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects
    Jing Ma
    University of Adelaide, Discipline of Medicine, Royal Adelaide Hospital, North Terr, Adelaide SA 5000, Australia
    Am J Physiol Gastrointest Liver Physiol 296:G735-9. 2009
    ..and GIP, and gastric emptying (by a breath test) in 7 healthy humans after intragastric infusions of 1) 50 g sucrose in water to a total volume of 500 ml (approximately 290 mosmol/l), 2) 80 mg sucralose in 500 ml normal saline (..
  17. ncbi Immobilized invertase
    S M Kotwal
    Division of Biochemical Sciences, National Chemical Laboratory, Pune 411008, India
    Biotechnol Adv 27:311-22. 2009
    Invertase is a commercially important enzyme used for the hydrolysis of sucrose. The hydrolysis of sucrose yields an equimolar mixture of glucose and fructose, known as invert syrup, is widely used in food and beverage industries...
  18. ncbi Temporal analysis of sucrose-induced phosphorylation changes in plasma membrane proteins of Arabidopsis
    Totte Niittyla
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Mol Cell Proteomics 6:1711-26. 2007
    b>Sucrose is the main product of photosynthesis and the most common transport form of carbon in plants. In addition, sucrose is a compound that serves as a signal affecting metabolic flux and development...
  19. pmc Sugar-induced increases in trehalose 6-phosphate are correlated with redox activation of ADPglucose pyrophosphorylase and higher rates of starch synthesis in Arabidopsis thaliana
    John E Lunn
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14424 Potsdam, Germany
    Biochem J 397:139-48. 2006
    ..The Tre6P content of sucrose-starved Arabidopsis thaliana seedlings in axenic culture increased from 18 to 482 pmol x g(-1) FW (fresh weight) ..
  20. pmc Sucrose synthase affects carbon partitioning to increase cellulose production and altered cell wall ultrastructure
    Heather D Coleman
    Department of Wood Science, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Proc Natl Acad Sci U S A 106:13118-23. 2009
    Overexpression of the Gossypium hirsutum sucrose synthase (SuSy) gene under the control of 2 promoters was examined in hybrid poplar (Populus alba x grandidentata)...
  21. ncbi Sucrose activates human taste pathways differently from artificial sweetener
    Guido K W Frank
    University of Colorado at Denver and Health Sciences Center, Department of Psychiatry, The Children s Hospital, Aurora, CO 80045, USA
    Neuroimage 39:1559-69. 2008
    Animal models suggest that sucrose activates taste afferents differently than non-caloric sweeteners. Little information exists how artificial sweeteners engage central taste pathways in the human brain...
  22. ncbi Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
    Dongfeng Cao
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 282:36275-82. 2007
    ..In the present study, we provided 10% sucrose-sweetened water to a transgenic mouse model of AD with a normal rodent diet...
  23. pmc Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice
    Tao Ma
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e21647. 2011
    ..Here we aimed to investigate if the amount of sucrose in the background diet influences the ability of n-3 PUFAs to protect against diet-induced obesity, adipose ..
  24. doi A nicotinic acetylcholine receptor agonist affects honey bee sucrose responsiveness and decreases waggle dancing
    Daren M Eiri
    Division of Biological Sciences, Section of Ecology, Behavior, and Evolution, University of California, San Diego, Mail Code 0116, 9500 Gilman Drive, La Jolla, CA 92093 0166, USA
    J Exp Biol 215:2022-9. 2012
    ..However, little is known about how this agonist affects two specific aspects of foraging: sucrose responsiveness (SR) and waggle dancing (which recruits nestmates)...
  25. ncbi Sucrose and starch catabolism in the anther of Lilium during its development: a comparative study among the anther wall, locular fluid and microspore/pollen fractions
    Antonio J Castro
    Laboratoire de Stress, Défenses et Reproduction des Plantes, Universite de Reims Champagne Ardenne, UFR Sciences, BP 1039, Moulin de la Housse, 51687, Reims Cedex 2, France
    Planta 225:1573-82. 2007
    In order to better understand the various pathways of sucrose and starch catabolism in the anther of lily (Lilium hybrida var. "Enchantment"), invertase (EC and amylase (EC, EC 3.2.1...
  26. pmc Expression of the Bacillus subtilis sacB gene confers sucrose sensitivity on mycobacteria
    V Pelicic
    Unite de Genetique Mycobacterienne, Centre National de la Recherche Scientifique URA 1300, Institut Pasteur, Paris, France
    J Bacteriol 178:1197-9. 1996
    ..sacB expression is lethal to Mycobacterium smegmatis and Mycobacterium bovis BCG in the presence of 10% sucrose. sacB could thus be used as a counterselectable marker in mycobacteria.
  27. doi Membrane-transport systems for sucrose in relation to whole-plant carbon partitioning
    Brian G Ayre
    University of North Texas, Department of Biological Sciences, Denton, Texas, USA
    Mol Plant 4:377-94. 2011
    b>Sucrose is the principal product of photosynthesis used for the distribution of assimilated carbon in plants...
  28. pmc Trehalose mediated growth inhibition of Arabidopsis seedlings is due to trehalose-6-phosphate accumulation
    Henriette Schluepmann
    Molecular Plant Physiology, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Plant Physiol 135:879-90. 2004
    ..Interestingly, Suc addition represses 15 of these genes, one of which is AtKIN11, encoding a Sucrose Non Fermenting 1 (SNF1)-related kinase known to play a role in Suc utilization.
  29. ncbi Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
    Janne Grønli
    Department of Biomedicine, Section of Physiology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Physiol Behav 84:571-7. 2005
    ..We have examined behavior (sexual activity and open field activity) together with hedonic measures (sucrose and saccharine intake) after exposure to CMS. CMS decreased male sexual activity (e.g...
  30. ncbi Trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization
    Stephanie Ravaud
    Laboratoire de BioCristallographie, Institut de Biologie et Chimie des Proteines, CNRS et Université de Lyon, UMR 5086, IFR 128 Biosciences Gerland Lyon Sud, F 69367 Lyon Cedex 07, France
    J Biol Chem 282:28126-36. 2007
    Various diseases related to the overconsumption of sugar make a growing need for sugar substitutes. Because sucrose is an inexpensive and readily available d-glucose donor, the industrial potential for enzymatic synthesis of the sucrose ..
  31. doi Food reward in the absence of taste receptor signaling
    Ivan E de Araujo
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 57:930-41. 2008
    ..which lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content...
  32. doi Dynamic protein composition of Arabidopsis thaliana cytosolic ribosomes in response to sucrose feeding as revealed by label free MSE proteomics
    Maureen Hummel
    Molecular Plant Physiology, Utrecht University, Utrecht, The Netherlands
    Proteomics 12:1024-38. 2012
    ..Immunopurified ribosomes were isolated from A. thaliana rosette leaves fed with sucrose. Trypsin digested samples were analyzed by qTOF-LC-MS using both MS(E) and classical MS/MS...
  33. pmc Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats
    Suzie Hong
    Department of Anesthesiology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, United States
    Physiol Behav 105:269-75. 2012
    ..Dawley rats on behavior in the forced swim test at the end of adolescence and in adulthood and on behavior in the sucrose preference test in adulthood...
  34. pmc High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO
    Hepatology 58:1632-43. 2013
    ..Wild-type or fructokinase knockout mice were fed a low-fat (11%), high-fat (36%), or high-fat (36%) and high-sucrose (30%) diet for 15 weeks...
  35. doi Hexoses as phloem transport sugars: the end of a dogma?
    Aart J E van Bel
    Plant Cell Biology Research Group, Institute of General Botany, Justus Liebig University, Senckenbergstrasse 17, D 35390 Giessen, Germany
    J Exp Bot 59:261-72. 2008
    According to most textbooks, only non-reducing carbohydrate species such as sucrose, sugar alcohols, and raffinose-family sugars function as phloem translocates...
  36. pmc A new subfamily of sucrose transporters, SUT4, with low affinity/high capacity localized in enucleate sieve elements of plants
    A Weise
    Plant Physiology, Zentrum für Molekularbiologie der Pflanzen, University of Tubingen, D 72076 Tubingen, Germany
    Plant Cell 12:1345-55. 2000
    A new subfamily of sucrose transporters from Arabidopsis (AtSUT4), tomato (LeSUT4), and potato (StSUT4) was isolated, demonstrating only 47% similarity to the previously characterized SUT1...
  37. doi Sugarcane for bioenergy production: an assessment of yield and regulation of sucrose content
    Alessandro J Waclawovsky
    Departamento de Bioquimica, Instituto de Quimica, Av Prof Lineu Prestes, Sao Paulo, Brazil
    Plant Biotechnol J 8:263-76. 2010
    ..The most important biofuel to date is bioethanol produced from sugars (sucrose and starch)...
  38. doi Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood-brain barrier in vitro and their influence on barrier integrity
    Ralf Rempe
    Department of Biochemistry, University of Muenster, Wilhelm Klemm Strasse 2, D 48149 Muenster, Germany
    Biochem Biophys Res Commun 406:64-9. 2011
    ..the integrity of the BBB in vitro was verified by measuring the passage of the reference substances (14)C-sucrose and FITC-BSA after addition of PBCA-NP...
  39. doi The potato sucrose transporter StSUT1 interacts with a DRM-associated protein disulfide isomerase
    Undine Krügel
    Institute of Biology, Department of Plant Physiology, Humboldt University, 10115 Berlin, Germany
    Mol Plant 5:43-62. 2012
    ..We used the yeast two-hybrid split ubiquitin system (SUS) to systematically screen for interaction between the sucrose transporter StSUT1 and other membrane-associated or soluble proteins in vivo...
  40. ncbi Sucrose-mediated priming of plant defense responses and broad-spectrum disease resistance by overexpression of the maize pathogenesis-related PRms protein in rice plants
    Jorge Gómez-Ariza
    Departamento de Genetica Molecular, Laboratório de Genética Molecular Vegetal, Consorcio CSIC IRTA, Jordi Girona 18, 08034 Barcelona, Spain
    Mol Plant Microbe Interact 20:832-42. 2007
    ..We also have found that sucrose accumulates at higher levels in leaves of PRms plants...
  41. doi Functional analysis of sucrose phosphate synthase (SPS) and sucrose synthase (SS) in sugarcane (Saccharum) cultivars
    A K Verma
    U P Council of Sugarcane Research, Shahjahanpur, India
    Plant Biol (Stuttg) 13:325-32. 2011
    b>Sucrose phosphate synthase (SPS; EC and sucrose synthase (SS; EC are key enzymes in the synthesis and breakdown of sucrose in sugarcane...
  42. pmc Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mechanism linking starch synthesis to the sucrose supply
    Axel Tiessen
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Cell 14:2191-213. 2002
    ..Furthermore, activation of AGPase resulted in a stimulation of starch synthesis and decreased levels of glycolytic intermediates...
  43. pmc Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets
    Fanny Ramel
    Centre National de la Recherche Scientifique, Universite de Rennes I, UMR 6553 Ecobio, Campus de Beaulieu, Bâtiment 14A, F 35042, Rennes Cedex, France
    BMC Plant Biol 9:28. 2009
    ..b>Sucrose has been shown to confer to Arabidopsis seedlings a high level of tolerance to the herbicide atrazine, which ..
  44. pmc Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial
    Rebeccah Slater
    Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK
    Lancet 376:1225-32. 2010
    Many infants admitted to hospital undergo repeated invasive procedures. Oral sucrose is frequently given to relieve procedural pain in neonates on the basis of its effect on behavioural and physiological pain scores...
  45. doi Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases
    Diana V Dugas
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
    Plant Mol Biol 67:403-17. 2008
    ..Here we show that miR398 is positively regulated by sucrose, resulting in decreased CSD1 and CSD2 mRNA and protein accumulation...
  46. doi Sucrose synthase is an integral component of the cellulose synthesis machinery
    Satoshi Fujii
    Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, 560 0043 Japan f
    Plant Cell Physiol 51:294-301. 2010 as the catalytic unit of cellulose synthesis, was enriched with a 78 kDa polypeptide which was verified as sucrose synthase like by mass spectrometry and immunoblotting...
  47. pmc Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:2184-6. 2009
    ..The goal of this study was to determine the effect of artificial sweeteners on glucose, insulin, and glucagon-like peptide (GLP)-1 in humans...
  48. ncbi Sucrose is involved in the diazotrophic metabolism of the heterocyst-forming cyanobacterium Anabaena sp
    Leonardo Curatti
    Centro de Investigaciones Biologicas, FIBA, Mar del Plata, Argentina
    FEBS Lett 513:175-8. 2002
    b>Sucrose synthase (SuS) expression was studied in the filamentous, nitrogen-fixing cyanobacterium Anabaena sp. PCC 7119...
  49. ncbi The sugar-insensitive1 (sis1) mutant of Arabidopsis is allelic to ctr1
    S I Gibson
    Department of Biochemistry and Cell Biology, MS140, Rice University, 6100 Main Street, Houston, Texas 77005 1892, USA
    Biochem Biophys Res Commun 280:196-203. 2001
    ..For example, exposure to high levels of glucose or sucrose inhibits early seedling development of Arabidopsis thaliana (L.) Heynh...
  50. pmc Dopaminergic modulation of sucrose acceptance behavior in Drosophila
    Sunanda Marella
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, 16 Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 73:941-50. 2012
    ..Here, we show that dopamine modulates a simple taste behavior, proboscis extension to sucrose. Conditional silencing of dopaminergic neurons reduces proboscis extension probability, and increased activation ..
  51. ncbi Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women
    Kathleen J Melanson
    Department of Nutrition and Food Sciences, University of Rhode Island, Kingston, Rhode Island, USA
    Nutrition 23:103-12. 2007
    ..This study examined effects of beverages sweetened with HFCS or sucrose (Suc), when consumed with mixed meals, on blood glucose, insulin, leptin, ghrelin, and appetite.
  52. ncbi No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads
    Stijn Soenen
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 86:1586-94. 2007
    ..It is unclear whether energy-containing drinks, especially those sweetened with high-fructose corn syrup (HFCS), promote positive energy balance and thereby play a role in the development of obesity...
  53. pmc Distribution of callose synthase, cellulose synthase, and sucrose synthase in tobacco pollen tube is controlled in dissimilar ways by actin filaments and microtubules
    Giampiero Cai
    Dipartimento Scienze Ambientali G Sarfatti, Universita di Siena, 53100 Siena, Italy
    Plant Physiol 155:1169-90. 2011
    ..Callose synthase also comigrates with tubulin by Blue Native-polyacrylamide gel electrophoresis. Membrane sucrose synthase, which expectedly provides UDP-glucose to callose synthase and cellulose synthase, binds to actin ..
  54. ncbi Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism
    Helen Pinfield-Wells
    CNAP, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Plant J 43:861-72. 2005
    ..In acx1-1 and acx2-1, seedling growth and establishment in the absence of an exogenous supply of sucrose was unaffected...
  55. ncbi Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress
    Stéphanie Pothion
    Key Obs SA, Parc Technologique, 3 allée du Titane, 16 rue Leonard de Vinci, 45100 Orleans, France
    Behav Brain Res 155:135-46. 2004
    ..These strains were chosen among 11 strains that were tested in a first experiment for their sucrose consumption and preference for sucrose solutions of different concentrations...
  56. pmc Impaired function of the tonoplast-localized sucrose transporter in rice, OsSUT2, limits the transport of vacuolar reserve sucrose and affects plant growth
    Joon Seob Eom
    Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Yongin 446 701, Korea
    Plant Physiol 157:109-19. 2011
    Physiological functions of sucrose (Suc) transporters (SUTs) localized to the tonoplast in higher plants are poorly understood. We here report the isolation and characterization of a mutation in the rice (Oryza sativa) OsSUT2 gene...
  57. pmc Daylength and circadian effects on starch degradation and maltose metabolism
    Yan Lu
    Department of Botany, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Physiol 138:2280-91. 2005
    ..Light is necessary for the cycling of transcript levels and maltose levels. Under continuous darkness, these genes were barely expressed, and no cycling of maltose levels was observed...
  58. doi The effects of long-term honey, sucrose or sugar-free diets on memory and anxiety in rats
    Lynne M Chepulis
    Department of Biological Sciences, Waikato University, Hamilton, New Zealand
    Physiol Behav 97:359-68. 2009
    b>Sucrose is considered by many to be detrimental to health, giving rise to deterioration of the body associated with ageing...
  59. doi Sucrose transporters of higher plants
    Christina Kuhn
    Humboldt University of Berlin, Institute of Biology, Department of Plant Physiology, Philippstrasse 13, Building 12, 10115 Berlin, Germany
    Curr Opin Plant Biol 13:288-98. 2010
    Recent advances have provided new insights into how sucrose is moved from sites of synthesis to sites of utilisation or storage in sink organs...
  60. pmc Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
    Zhenyuan Song
    Dept of Medicine, Univ of Louisville Medical Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 293:G894-902. 2007
    ..In this study, we examined the effects of betaine on fat accumulation in the liver induced by high-sucrose diet and evaluated mechanisms by which betaine could attenuate or prevent hepatic steatosis in this model...
  61. ncbi Impaired sucrose-induction mutants reveal the modulation of sugar-induced starch biosynthetic gene expression by abscisic acid signalling
    F Rook
    Department of Molecular Genetics, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant J 26:421-33. 2001
    ..Of the four impaired sucrose induction (isi) mutants described here, two (isi1 and isi2) were specific to this screen...
  62. pmc Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila
    Yuchen Jiao
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 18:1797-801. 2008
    ..Disruption of Gr5a prevents the detection of trehalose [1-3], whereas mutation of Gr64a impairs the responses to sucrose, maltose, and glucose [4, 5]...
  63. doi Sucrose: metabolite and signaling molecule
    Julia Wind
    Molecular Plant Physiology, Utrecht University, Utrecht, The Netherlands
    Phytochemistry 71:1610-4. 2010
    b>Sucrose is a molecule that is synthesized only by oxygenic photosynthetic organisms. In plants, sucrose is synthesized in source tissues and then can be transported to sink tissues, where it is utilized or stored...
  64. ncbi The relationship between lumenal and limiting membranes in swollen late endocytic compartments formed after wortmannin treatment or sucrose accumulation
    N A Bright
    Department of Clinical Biochemistry and Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Traffic 2:631-42. 2001
    ..were used to evaluate the formation of swollen endosomes in NRK cells after treatment with wortmannin or sucrose and to study the relationship between lumenal and limiting membrane...
  65. doi Sucrose for analgesia in newborn infants undergoing painful procedures
    Bonnie Stevens
    Associate Chief of Nursing Research, The Hospital for Sick Children, Toronto, Canada
    Cochrane Database Syst Rev 1:CD001069. 2013
    Administration of oral sucrose with and without non-nutritive sucking is the most frequently studied non-pharmacological intervention for procedural pain relief in neonates.
  66. pmc High invertase activity in tomato reproductive organs correlates with enhanced sucrose import into, and heat tolerance of, young fruit
    Zhimiao Li
    Institute of Vegetables, Zhejiang Academy of Agricultural Sciences, 198 Shiqiao Road, Hangzhou 310021, China
    J Exp Bot 63:1155-66. 2012
    ..We examined patterns of carbon allocation and activities of sucrose cleavage enzymes in heat-tolerant (HT) and -sensitive (HS) tomato (Solanum lycopersicum L...
  67. pmc Sucrose importation into laticifers of Hevea brasiliensis, in relation to ethylene stimulation of latex production
    Anaïs Dusotoit-Coucaud
    UMR 547 PIAF, INRA, Universite Blaise Pascal, 24 avenue des Landais, 63177 Aubiere Cedex, France
    Ann Bot 104:635-47. 2009
    ..The latex yield is stimulated by ethylene. Sucrose, the unique precursor of rubber synthesis, must cross the plasma membrane through specific sucrose transporters ..
  68. ncbi Human taste thresholds are modulated by serotonin and noradrenaline
    Tom P Heath
    Department of Physiology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:12664-71. 2006
    ..a 5-HT reuptake inhibitor, NA reuptake inhibitor, or placebo showed that enhancing 5-HT significantly reduced the sucrose taste threshold by 27% and the quinine taste threshold by 53%...
  69. ncbi Responses of primary and secondary metabolism to sugar accumulation revealed by microarray expression analysis of the Arabidopsis mutant, pho3
    Julie C Lloyd
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    J Exp Bot 55:1221-30. 2004
    The Arabidopsis mutant pho3 accumulates sucrose and other carbohydrates to high levels, providing a means of investigating the genomic response to sucrose accumulation using microarray analysis...
  70. doi Evolutionary differences in food preference rely on Gr64e, a receptor for glycerol
    Zev Wisotsky
    Interdepartmental Neuroscience Program, University of California, Riverside, California, USA
    Nat Neurosci 14:1534-41. 2011
    ..Our results provide insight into the molecular mechanisms of feeding acceptance of yeast products and raise the possibility that Gr64e contributes to specific evolutionary variations in appetitive selectivity across Drosophila species...
  71. ncbi Involvement of soluble sugars in reactive oxygen species balance and responses to oxidative stress in plants
    Ivan Couée
    Centre National de la Recherche Scientifique, Universite de Rennes 1, UMR 6553 Ecobio, Campus de Beaulieu, Bâtiment 14A, F 35042 Rennes Cedex, France
    J Exp Bot 57:449-59. 2006
    Soluble sugars, especially sucrose, glucose, and fructose, play an obviously central role in plant structure and metabolism at the cellular and whole-organism levels...
  72. doi The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism
    Jingkun Ma
    Centre for Signal Transduction and Metabolomics, Institute of Botany, The Chinese Academy of Sciences, Naxincun 20, Beijing 100093, China
    New Phytol 191:733-45. 2011
    The Arabidopsis basic region-leucine zipper transcription factor 11 (bZIP11) is known to be repressed by sucrose through a translational inhibition mechanism that requires the conserved sucrose control peptide encoded by the mRNA ..
  73. pmc Photosynthetic sucrose acts as cotyledon-derived long-distance signal to control root growth during early seedling development in Arabidopsis
    Stefan Kircher
    Department of Plant Physiology, Faculty of Biology, Albert Ludwigs University, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 109:11217-21. 2012
  74. ncbi De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women
    R M McDevitt
    Department of Biochemistry and Nutrition, Scottish Agricultural College, Ayr, United Kingdom
    Am J Clin Nutr 74:737-46. 2001
    ..The results of previous studies suggest that de novo lipogenesis may play an important role in the etiology of obesity, particularly during overconsumption of different carbohydrates...
  75. doi Vacuoles release sucrose via tonoplast-localised SUC4-type transporters
    S Schneider
    Molekulare Pflanzenphysiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Plant Biol (Stuttg) 14:325-36. 2012
    Arabidopsis thaliana has seven genes for functionally active sucrose transporters. Together with sucrose transporters from other dicot and monocot plants, these proteins form four separate phylogenetic groups...
  76. pmc Downregulation of pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase activity in sugarcane culms enhances sucrose accumulation due to elevated hexose-phosphate levels
    Margaretha J van der Merwe
    Institute of Plant Biotechnology, University of Stellenbosch, Merriman Avenue, Stellenbosch 7602, South Africa
    Planta 231:595-608. 2010
    ..In three independent transgenic lines, sucrose concentrations increased between three- and sixfold in immature internodes, compared to the levels in the ..
  77. pmc Sucrose metabolism contributes to in vivo fitness of Streptococcus pneumoniae
    Ramkumar Iyer
    Howard Hughes Medical Institute, Tufts University, Boston, MA 02110, USA
    Mol Microbiol 66:1-13. 2007
    We characterized two sucrose-metabolizing systems -sus and scr- and describe their roles in the physiology and virulence of Streptococcus pneumoniae in murine models of carriage and pneumonia...
  78. doi Sensing embolism in xylem vessels: the role of sucrose as a trigger for refilling
    Francesca Secchi
    Arnold Arboretum of Harvard University, BioLabs 3114, 16 Dinivity Ave, Cambridge, MA 02138, USA
    Plant Cell Environ 34:514-24. 2011
    ..Analysis of Populus trichocarpa's response to infiltration of sucrose, monosaccharides, polyethylene glycol and potassium chloride into the xylem revealed that only presence of ..
  79. pmc Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression
    Marcus A Lawson
    Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:1569-75. 2011
    ..Furthermore, adult C57BL/6J mice injected with Tat and tested in a two-bottle 1% sucrose preference test displayed reduced preference for sucrose during the 24 h post-injection period...
  80. ncbi Restricted access to food, but not sucrose, saccharine, or salt, synchronizes the expression of Period2 protein in the limbic forebrain
    E Waddington Lamont
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, Quebec, Canada
    Neuroscience 144:402-11. 2007
    ..Daily limited access to sucrose or saccharine in freely fed rats or scheduled access to saline in sodium-deprived rats had no effect on these ..
  81. doi Sucrose transporter NtSUT4 from tobacco BY-2 involved in plant cell shape during miniprotoplast culture
    Emiko Okubo-Kurihara
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha 5 1 5, Kashiwa, Chiba, 277 8562, Japan
    J Plant Res 124:395-403. 2011
    b>Sucrose plays an important role in several cellular processes since it is a general source of metabolic energy, serves as a precursor for starch and cellulose synthesis, and is a metabolic starting point for carboxylate- and amino acid ..
  82. doi Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum
    Xiongzhao Zhu
    Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Behav Brain Res 223:329-35. 2011
    ..This process is associated with down-regulated Par-4 and DRD2 gene expression in the striatum through a non-methylation mechanism...
  83. doi Identification of an animal sucrose transporter
    Heiko Meyer
    Department of Biology and Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Cell Sci 124:1984-91. 2011
    ..Here, we present the first report of an animal sucrose transporter, SCRT, which we detected in Drosophila melanogaster at each developmental stage...
  84. doi AKINbeta1 is involved in the regulation of nitrogen metabolism and sugar signaling in Arabidopsis
    Xiao Fang Li
    School of Life Sciences, East China Normal University, Shanghai 200062, China
    J Integr Plant Biol 51:513-20. 2009
    b>Sucrose non-fermenting-1-related protein kinase 1 (SnRK1) has been located at the heart of the control of metabolism and development in plants. The active SnRK1 form is usually a heterotrimeric complex...
  85. doi Metabolism of soluble sugars in developing melon fruit: a global transcriptional view of the metabolic transition to sucrose accumulation
    Nir Dai
    Institute of Plant Science, Agricultural Research Organization, Bet Dagan, Israel
    Plant Mol Biol 76:1-18. 2011 a metabolic transition during its development that leads to extensive accumulation of the disaccharide sucrose in the mature fruit...
  86. ncbi Doubled sugar content in sugarcane plants modified to produce a sucrose isomer
    Luguang Wu
    Botany Department SIB, The University of Queensland, Brisbane, QLD 4072, Australia
    Plant Biotechnol J 5:109-17. 2007
    b>Sucrose is the feedstock for more than half of the world's fuel ethanol production and a major human food. It is harvested primarily from sugarcane and beet...
  87. pmc Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues
    James E McCutcheon
    Department of Psychology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Synapse 66:346-51. 2012
    ..sweetener (saccharin) would evoke similar dopamine release as cues paired with a nutritive sweetener (sucrose). We trained food-restricted rats to associate distinct cues with sucrose or saccharin pellets...
  88. pmc Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
    Mitchell F Roitman
    Department of Psychology, University of Illinois, Chicago, Illinois 60607, USA
    Nat Neurosci 11:1376-7. 2008
    ..This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry...
  89. doi Screening of valid reference genes for real-time RT-PCR data normalization in Hevea brasiliensis and expression validation of a sucrose transporter gene HbSUT3
    Heping Li
    Key Lab of Rubber Biology, Ministry of Agriculture and Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan 571737, China
    Plant Sci 181:132-9. 2011
    ..In addition, examination of relative expression of a sucrose transporter HbSUT3 in different RNA samples demonstrated the importance of additional reference genes to ensure ..
  90. ncbi Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Pediatrics 116:921-6. 2005
    ..We chose to examine sucrose, cola drink, honey, human milk, cow milk, and water because some of these have been associated with development ..
  91. ncbi A flux model of glycolysis and the oxidative pentosephosphate pathway in developing Brassica napus embryos
    Jorg Schwender
    Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:29442-53. 2003
    Developing oilseeds synthesize large quantities of triacylglycerol from sucrose and hexose...
  92. doi Prospects for increasing starch and sucrose yields for bioethanol production
    Alison M Smith
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 54:546-58. 2008
    ..b>Sucrose accumulation is much less well understood than starch synthesis, but recent results from research on sugar cane ..
  93. pmc Mrt, a gene unique to fungi, encodes an oligosaccharide transporter and facilitates rhizosphere competency in Metarhizium robertsii
    Weiguo Fang
    Department of Entomology, University of Maryland, College Park, Maryland 20742, USA
    Plant Physiol 154:1549-57. 2010
    ..Here, we demonstrate that sucrose and raffinose family oligosaccharides in root exudates are important for rhizosphere competence in the insect ..
  94. pmc Sucrose phosphate synthase activity rises in correlation with high-rate cellulose synthesis in three heterotrophic systems
    V M Babb
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
    Plant Physiol 127:1234-42. 2001
    Based on work with cotton fibers, a particulate form of sucrose (Suc) synthase was proposed to support secondary wall cellulose synthesis by degrading Suc to fructose and UDP-glucose...
  95. pmc A cytosolic acyltransferase contributes to triacylglycerol synthesis in sucrose-rescued Arabidopsis seed oil catabolism mutants
    M Luisa Hernandez
    Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, United Kingdom
    Plant Physiol 160:215-25. 2012
    Triacylglycerol (TAG) levels and oil bodies persist in sucrose (Suc)-rescued Arabidopsis (Arabidopsis thaliana) seedlings disrupted in seed oil catabolism...
  96. pmc Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects
    Myphuong T Le
    Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    Metabolism 61:641-51. 2012 immediate source of free fructose, induces greater systemic concentrations of fructose as compared with sucrose. It is also unclear whether exposure to higher levels of fructose leads to increased fructose-induced adverse ..
  97. pmc Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking
    Pia Steensland
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 104:12518-23. 2007
    ..administration of varenicline, in doses reported to reduce nicotine reward, selectively reduced ethanol but not sucrose seeking using an operant self-administration drinking paradigm and also decreased voluntary ethanol but not water ..
  98. pmc Rice SPK, a calmodulin-like domain protein kinase, is required for storage product accumulation during seed development: phosphorylation of sucrose synthase is a possible factor
    Takayuki Asano
    Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda 278 8510, Japan
    Plant Cell 14:619-28. 2002
    ..This finding suggests that SPK is involved in the activation of Suc synthase. It appears that SPK is a Suc synthase kinase that may be important for supplying substrates for the biosynthesis of storage products...
  99. ncbi Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 7:100-7. 2004
    ..g of dextrose or 90 g of honey on PGL in seven patients with type 2 diabetes mellitus; and (7) effects of 30 g of sucrose or 30 g of honey on PGL, plasma insulin, and plasma C-peptide in five diabetic patients...
  100. pmc ADP-glucose pyrophosphorylase is activated by posttranslational redox-modification in response to light and to sugars in leaves of Arabidopsis and other plant species
    Janneke H M Hendriks
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:838-49. 2003
    ..AGPB is converted from a dimer to monomer when sucrose is supplied to leaves via the petiole in the dark...
  101. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
    The combination of sucrose and starch in the presence of surface-adsorbed salivary α-amylase and bacterial glucosyltransferases increase the formation of a structurally and metabolically distinctive biofilm by Streptococcus mutans...

Research Grants69

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..and C57BL/6 mice treated with ANG II that produces a slow pressor response and/or a high fat (60%) and high sucrose (20%) diet. A cohort of animals will be treated with an AT1R blocker (olmesartan) at a dose of 0...
  3. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..A western diet (WD), especially characterized by excess intake of high fat, high sucrose and carbohydrates, is a major factor in the increased prevalence of hypertension and diabetes...
  4. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..Premature infants experiencing heel lance will be randomized into either a placebo or sucrose intervention group...
  5. Mechanisms of diet-induced leptin resistance in ARC and VTA
    Philip J Scarpace; Fiscal Year: 2013
    ..Diets high in fat and sucrose lead to leptin resistance and obesity, yet the causative dietary ingredient(s) remain elusive...
  6. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..Projects 3 and 1) and atherogenic changes in the aorta (Project 2) in control mice and mice fed a high-fat/high sucrose diet...
  7. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..Our data suggest the BOLD response of this network to tastes of sucrose is diminished in REC AN and is negatively associated with ventral putamen [11C]raclopride BP...
  8. Mineralocorticoid Receptor-Mediated Vascular Insulin Resistance
    SHAWN BRADY BENDER; Fiscal Year: 2013
    ..IR will be induced in wild-type and VSMC MR KO mice with a high-fat, high-sucrose diet and will be assessed by glucose tolerance testing.
  9. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..riboflavin, vitamin B6, vitamin B12, zinc;and 3) glycemic control - dietary glycemic load;intake of glucose, sucrose, fructose, fiber. For our second Aim, we will consider the HPA axis pathway...
  10. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..determine whether the ability of regular exercise to diminish atherosclerosis in LDLR-/- mice fed a high fat-high sucrose diet is attenuated in mice genetically lacking SIRT1 or one of the other signals. In addition, Dr...
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..sub-cellular fraction of tracheal epithelial cells and do indeed form a complex in vivo that sediments on sucrose gradients at around 50 Svedbergs...
  12. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..Sleep outcomes include arousal state, latencies to state and sleep-state specific EEG spectral profiles. Sucrose 1% versus plain water preference is monitored daily from 1 week prior to social defeat / novel cage exposure ..
  13. Nutrition and Physical Activity Assessment Study (NPAAS)
    Ross L Prentice; Fiscal Year: 2013
    ..We will obtain 24-h urine-derived nutritional measures, including nitrogen (protein), fructose, sucrose (sugars), alkylresorcinols (whole grains) and 1- and 3- methylhistidine (meat);and blood-derived nutritional ..
  14. PLCgamma regulates HNE3 activity through direct binding and dynamic complexes
    ..Biochemical studies, including sucrose density gradient centrifugation, will be performed to analyze the contribution of PLCg on formation of NHE3 ..
  15. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012 then challenged with OVA antigen and evaluated in the open field, elevated plus maze, social interaction and sucrose preference tests...
    Barry E Levin; Fiscal Year: 2013
    ..glucoprivic feeding but lowering it had no effect on energy homeostasis or glucose tolerance in rats fed low, low sucrose diets...
  17. NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Edward J Weinman; Fiscal Year: 2013
    ..if dopamine dissociates Npt2a/NHERF-1 complexes using quantitative immunoprecipitation, confocal microscopy, and sucrose density gradient ultracentrifugation...
  18. Regulation of Carbohydrate Metabolism and Lipogenesis
    Kosaku Uyeda; Fiscal Year: 2013
    ..We also will investigate other glucose signaling compounds in high sucrose fed rat liver extracts that may increase importin [unreadable] binding and/or destabilize 14-3-3 binding to ..
    ..or cell signaling inhibitors to modulate performance in a behavioral task that models diet recidivism, relapse to sucrose-seeking;2) the effect of high fat diet experience on sucrose self-administration in pre- and post-pubertal rats;..
  20. Sex Differences in the Roles of Oxytocin and Vasopressin in Social Withdrawal
    Michael Q Steinman; Fiscal Year: 2013
    ..Diminished reward can result in reduced consumption of sucrose and reduced time engaging in social interaction...
  21. Metabolic and Energetic Consequences of Fatherhood
    Wendy Saltzman; Fiscal Year: 2013
    ..thyroxine;2) blood triglyceride, cholesterol, and glucose levels;3) the propensity to ingest high-fat and high-sucrose substances;and 4) organ masses and distribution of fat stores, in nonbreeding males, new fathers, and experienced ..
  22. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ..will define whether the presence of La stimulates active MMP2-mRNA translation in oral SCC cells by performing sucrose-density gradients...
  23. Screening New Therapeutics for the Treatment of Post Traumatic Stress Disorder
    NEAL GORDON SIMON; Fiscal Year: 2011
    ..we have shown using fMRI that rats exposed to a natural predator, a ferret, while experiencing the taste of sucrose exhibit a hyperarousal pattern of brain activity in the limbic cortex and hippocampus in response to the taste of ..
  24. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    ..effects of caffeine on consumption of foods and beverages containing added sugar and sensitivity to and liking of sucrose will also be assessed...
  25. Macrophage, ABCA1, Inflammation, and Atherosclerosis
    John S Parks; Fiscal Year: 2012
    ..In Specific aim 3, our preliminary data demonstrated that MSKO mice fed a high fat/high sucrose (HF/HS) diet have increased body weight, increased hepatic lipid content, and systemic insulin resistance ..
  26. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..Dental caries is initiated by increased prevalence of mutans streptococci, which metabolize sucrose to lactic acid and create an acidic local environment that demineralizes tooth enamel and causes tooth decay...
  27. Regulation of Food Intake via the Glucagon-Like Peptide-1 Receptor
    Julio E Ayala; Fiscal Year: 2013
    ..This could partially explain our observation that mice fed a sucrose diet, which provides fructose and glucose, eat more compared to mice fed an isocaloric starch diet that only ..
  28. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2013
    ..of specific expectation: the first task, a go/no-go in which one tone cues the availability of a palatable taste (sucrose or NaCl) and the other a punishment (quinine) at a press of a lever, will reveal the effects of expectation of ..
  29. Redox Regulation of p21ras in Angiogenesis
    Richard A Cohen; Fiscal Year: 2013
    ..Results of these studies in EC in culture will be relevant for our studies in obese mice fed a high fat, high sucrose (HFHS) diet in which we find angiogenesis to be impaired...
  30. Role of elF2a phosphorylation and ER stress in hypoxia tolerance and tumor growth
    Constantinos Koumenis; Fiscal Year: 2013
    ..We will also identify mediators of angiogenesis downstream of GCN2 and PERK using antibody arrays and sucrose sedimentation analysis of actively translated mRNAs...
  31. Obesity, Inflammation and BPH
    Simon W Hayward; Fiscal Year: 2013
    ..receptor knockout (ob/ob) and low density lipoprotein receptor knockout (LDLR-/-) C57/BL6 mice by high fat/high sucrose or high fat/high corn starch dietary regimens...
  32. Gustatory Control of Sodium Appetite
    Ralph Norgren; Fiscal Year: 2012
    ..We use the release of dopamine (DA) in the nucleus accumbens as a forebrain index of reward. Sham licking sucrose produces a substantial efflux of accumbens DA even in experienced animals...
    M Joan Curcio; Fiscal Year: 2013
    ..Moreover, we have found that Ty1 RNA is translationally repressed in sucrose-dense ribonucleoprotein particles and that TyA is associated with cytoplasmic mRNA processing bodies (P bodies), ..
  34. A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
    KAY MAXINE TYE; Fiscal Year: 2013
    ..Specifically, the project outline will begin by identifying neural circuits mediating compulsive sucrose seeking...
  35. Mitochondrial rhomboid function in yeast
    Donna M Gordon; Fiscal Year: 2010
    ..In a biochemical approach, sucrose gradient ultracentrifugation and Blue-Native PAGE analysis will be carried out to characterize the biophysical ..
  36. Poly ADP-ribose Polymerase in Chromatin and Transcriptional Regulation
    Alexei V Tulin; Fiscal Year: 2012
    ..novel chromatin-associated PARP1 partners by use of a Tandem Affinity Purification (TAP) strategy together with sucrose gradient purification and liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
  37. Refined Fructose Promotes Pancreatic Cancer Growth
    Anthony P Heaney; Fiscal Year: 2011
    ..of increased consumption of beverages that are high in fructose and the consumption of other foods sweetened with sucrose and high-fructose corn syrup (HFCS)...
  38. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn E Carroll; Fiscal Year: 2012
    ..g., cocaine, heroin) and nondrug (e.g., wheel-running, and sucrose intake) rewards...
  39. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..based on the physical and coagulation properties of a mixture of Teleostan Gelatin type A, Polyvinylpyrrolidone, Sucrose and Fibrinogen, with a water-soluble foam inducer; the addition of thrombin and P-selectin inmunoglobin chimera, ..
  40. Increased vulnerability of BDNF deficient mice to mild stress
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ..To this end, we will measure in BDNF() mice immobility in the forced swim test (Specific Aim 2) and sucrose consumption in a two bottle choice test (Specific Aim 3)...
  41. SWI/SNF complex loss facilitates gene silencing during NSCLC development
    Bernard E Weissman; Fiscal Year: 2010
    ..In particular, the SWI/SNF (mating type switch/sucrose nonfermenting) chromatin remodeling complex appears like a strong candidate for contributing to epigenetic ..
  42. Identification of the gene and protein product responsible for Golgi casein kinas
    STEPHANIE MARIE NUNEZ; Fiscal Year: 2013
    ..use rat liver homogenates to purify Golgi fractions using an ultracentrifuge technique and solutions of variable sucrose density...
  43. Hedonic vs. Metabolic Processing by the Nucleus Accumbens
    James Edgar McCutcheon; Fiscal Year: 2013
    ..For Aims 1 and 2, sucrose will be compared to the non-caloric sweetener saccharin...
  44. The Role of an Intraflagellar Transport Protein in Cell-Cycle Control
    Christopher R Wood; Fiscal Year: 2010
    ..Next, an IFT27-containing sucrose gradient fraction will be obtained from cytoplasmic protein extracts prepared during the cell cycle stage at ..
  45. Aortic Stiffness and Hypertension in Obese Mice
    Richard A Cohen; Fiscal Year: 2013
    ..Our preliminary studies in normal mice made obese by feeding a diet which is high in fat (30%) and sucrose (30%, HFHS), and is typical of that consumed by many Americans, show an association between increased aortic tone ..
  46. CNS Mechanisms that Modulate Reward
    Kenneth D Carr; Fiscal Year: 2013
    ..AMPA receptor GluA1 subunits in nucleus accumbens (NAc) postsynaptic density (PSD), (ii) psychostimulant- and sucrose-induced phosphorylation of GluA1 on Ser845, and (iii) psychostimulant- and sucrose-induced delivery of GluA1 and ..
  47. Sex Differences in Stress-Induced Genome-Wide Transcriptional Profiles
    Scott J Russo; Fiscal Year: 2013
    ..For example, females exhibit greater immobility on the forced swim test (FST), anhedonic responses on sucrose preference tests (SPT), decreased time grooming on the splash test, increased latency to feed on novelty ..
  48. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..In Specific Aim 1, interaction of drugs with excipients such as sweeteners (e.g., saccharin, sucralose, sucrose) and diluents/binder (e.g., microcrystalline cellulose, dicalcium phosphate) will be examined...
  49. Translational Regulation of Mosquito mRNAs during Plasmodium Infection
    Jinsong Zhu; Fiscal Year: 2010
    ..We will use sucrose density gradient centrifugation to separate mRNAs associated with polyribosomes from those that are ..
  50. An Advanced Biosensor for Molecular Interaction Studies.
    SCOT RANDY WEINBERGER; Fiscal Year: 2013
    ..Yet, the tools available to quantify these interactions have limitations. Traditional methods such as the sucrose gradient technique or isothermal titrimetric calorimetry are laborious and require substantial quantities of ..
  51. Food Reward and Stress
    YVONNE MICHELLE ULRICH-LAI; Fiscal Year: 2013 which rats with free access to food and water are given twice-daily access to a small amount of palatable sucrose solution or water as a control...
  52. Temporal Coding in the Gustatory System of the Brain
    Patricia M Di Lorenzo; Fiscal Year: 2013
    ..of electrical stimulation can mimic the perceptual properties and behavioral reactivity of either quinine or sucrose and b) construct a temporal sequence of electrical pulses which incorporates the critical features of the ..
  53. Neurobiology of Anorexia and Bulimia Nervosa
    Walter H Kaye; Fiscal Year: 2013
    ..We will use a sucrose gustatory challenge and will provoke homeostasis by comparing a hungry state to a satiated state...
  54. Ontogeny of Drug Exposure and Mood Dysregulation.
    Carlos A Bolanos; Fiscal Year: 2013
    ..a) behavioral reactivity to emotion-eliciting stimuli (open-field, elevated plus-maze, forced swim stress, sucrose preference), (b) natural (sucrose) and (c) drug reward (nicotine and cocaine)...
    James A Bibb; Fiscal Year: 2013
    ..its modulation during acquisition of self-administration (SA), chronic SA, and extinction after withdrawal from sucrose and cocaine SA in mice...
  56. The role of protein kinase Mzeta in hippocampal-dependent memory maintenance.
    JANINE LYNN KWAPIS; Fiscal Year: 2013
    ..the radial arm maze task, rats must use spatial cues to determine which 4 of the 8 available arms contain hidden sucrose pellets...
  57. MicroRNA regulation of addiction-related genes and drug abuse-related behavior
    RYAN BASTLE; Fiscal Year: 2013
    ..Furthermore, we plan to use the same manipulations on sucrose reinforcement to test whether our effects are specific to cocaine...
  58. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2013
    ..g., sucrose), intracranial self-stimulation (ICSS) and cocaine self-administration...
  59. Role of the SrmB Helicase in Ribosome Assembly investigated by Mass Spectrometry
    Carla F Cervantes; Fiscal Year: 2013
    ..coli strain, fractionally separated by sucrose gradient ultracentrifugation...
    Patricia Sue Grigson; Fiscal Year: 2013
    ..contrast paradigm where rats avoid intake of a similar taste cue when it predicts access to a highly rewarding sucrose solution...
  61. Development of a novel NF-kB antagonist to block cytokine-induced behavioral chan
    THADDEUS W PACE; Fiscal Year: 2010
    ..g. reduced locomotor activity) and later phase (e.g. reduced sucrose preference, decreased struggling in the forced swim test) behaviors...
  62. Biomarkers of Dietary Variables Commonly Misreported
    Megan A McCrory; Fiscal Year: 2010
    ..We will test our hypotheses by assessing a combination of novel (urinary sucrose + fructose for foods high in sugar) and established (plasma carotenoids and serum phylloquinone for fruits and ..
  63. Substrate Selection in Homologous Bacterial Transporters
    Manuel Varela; Fiscal Year: 2004
    ..coli (LacY) also confer sugar selection in homologous transporters for melibiose (MelY), raffinose (RafB) and sucrose (CseB)...
    CHARLES SPARKS; Fiscal Year: 1990
    ..In rabbits fed semi-purified diets, sucrose as a carbohydrate source results in hyperlipoproteinemia in excess of that of dietary glucose or fructose...
    Yvonne Lange; Fiscal Year: 1990
    ..The proposed approach will involve subcellular fractionation of cell homogenates by equilibrium sucrose density centrifugation, rate zonal sedimentation in sucrose gradients and two phase aqueous partition...
  66. Effects of Clopazine and haloperidol on responding
    Danielle Gulick; Fiscal Year: 2010
    ..the CPP paradigm;(3) to determine whether the hamster shows a higher motivation to consume alcohol and isocaloric sucrose, compared to saccharin, water, and food, in an OSA paradigm;and (4) to determine whether HAL, but not CLOZ, will ..
  67. Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo
    CHIFU HUANG; Fiscal Year: 2006
    ..sweeteners that are commercially available, designed to provide zero- or low-calorie artificial alternatives to sucrose/high fructose corn syrup, there remain concerns regarding potential health concerns in the general population or ..
    RONALD DOYLE; Fiscal Year: 1993
    ..These bacteria are acidogenic and aciduric. The mutans streptococci can also utilize sucrose as a source of fermentable carbohydrate and as a substrate for D-glucan synthesis...
  69. Development of Novel Therapies or Methamphetamine Abuse
    Linda Dwoskin; Fiscal Year: 2009
    ..a complete blockade of methamphetamine self-administration (SA) in rats, without any alteration in responding for sucrose, i.e., it specifically decreases methamphetamine SA...