sucrose

Summary

Summary: A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.

Top Publications

  1. doi Sucrose efflux mediated by SWEET proteins as a key step for phloem transport
    Li Qing Chen
    Carnegie Institution for Science, 260 Panama Street, Stanford, CA 94305, USA
    Science 335:207-11. 2012
  2. doi Membrane-transport systems for sucrose in relation to whole-plant carbon partitioning
    Brian G Ayre
    University of North Texas, Department of Biological Sciences, Denton, Texas, USA
    Mol Plant 4:377-94. 2011
  3. pmc Impaired function of the tonoplast-localized sucrose transporter in rice, OsSUT2, limits the transport of vacuolar reserve sucrose and affects plant growth
    Joon Seob Eom
    Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Yongin 446 701, Korea
    Plant Physiol 157:109-19. 2011
  4. ncbi Sucrose transporters of higher plants
    Christina Kuhn
    Humboldt University of Berlin, Institute of Biology, Department of Plant Physiology, Philippstrasse 13, Building 12, 10115 Berlin, Germany
    Curr Opin Plant Biol 13:288-98. 2010
  5. pmc Sucrose utilization in budding yeast as a model for the origin of undifferentiated multicellularity
    John H Koschwanez
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 9:e1001122. 2011
  6. pmc Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
    Jemma K Richards
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 199:109-17. 2008
  7. doi Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2
    Alexander Schulz
    University of Wuerzburg, Institute for Molecular Plant Physiology and Biophysics, Julius von Sachs Platz 2, D 97082 Wuerzburg, Germany
    Plant J 68:129-36. 2011
  8. doi The sucrose transporter family in Populus: the importance of a tonoplast PtaSUT4 to biomass and carbon partitioning
    Raja S Payyavula
    School of Forest Resources and Environmental Sciences, Michigan Technological University, Houghton, MI 49931, USA
    Plant J 65:757-70. 2011
  9. doi The effects of long-term honey, sucrose or sugar-free diets on memory and anxiety in rats
    Lynne M Chepulis
    Department of Biological Sciences, Waikato University, Hamilton, New Zealand
    Physiol Behav 97:359-68. 2009
  10. pmc The Arabidopsis plastid-signalling mutant gun1 (genomes uncoupled1) shows altered sensitivity to sucrose and abscisic acid and alterations in early seedling development
    Amanda Cottage
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    J Exp Bot 61:3773-86. 2010

Detail Information

Publications285 found, 100 shown here

  1. doi Sucrose efflux mediated by SWEET proteins as a key step for phloem transport
    Li Qing Chen
    Carnegie Institution for Science, 260 Panama Street, Stanford, CA 94305, USA
    Science 335:207-11. 2012
    Plants transport fixed carbon predominantly as sucrose, which is produced in mesophyll cells and imported into phloem cells for translocation throughout the plant...
  2. doi Membrane-transport systems for sucrose in relation to whole-plant carbon partitioning
    Brian G Ayre
    University of North Texas, Department of Biological Sciences, Denton, Texas, USA
    Mol Plant 4:377-94. 2011
    b>Sucrose is the principal product of photosynthesis used for the distribution of assimilated carbon in plants...
  3. pmc Impaired function of the tonoplast-localized sucrose transporter in rice, OsSUT2, limits the transport of vacuolar reserve sucrose and affects plant growth
    Joon Seob Eom
    Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Yongin 446 701, Korea
    Plant Physiol 157:109-19. 2011
    Physiological functions of sucrose (Suc) transporters (SUTs) localized to the tonoplast in higher plants are poorly understood. We here report the isolation and characterization of a mutation in the rice (Oryza sativa) OsSUT2 gene...
  4. ncbi Sucrose transporters of higher plants
    Christina Kuhn
    Humboldt University of Berlin, Institute of Biology, Department of Plant Physiology, Philippstrasse 13, Building 12, 10115 Berlin, Germany
    Curr Opin Plant Biol 13:288-98. 2010
    Recent advances have provided new insights into how sucrose is moved from sites of synthesis to sites of utilisation or storage in sink organs...
  5. pmc Sucrose utilization in budding yeast as a model for the origin of undifferentiated multicellularity
    John H Koschwanez
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 9:e1001122. 2011
    ..Yeast cells can cooperate by secreting invertase, an enzyme that digests sucrose into monosaccharides, and many wild isolates are multicellular because cell walls remain attached to each other ..
  6. pmc Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
    Jemma K Richards
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 199:109-17. 2008
    ..In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking.
  7. doi Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2
    Alexander Schulz
    University of Wuerzburg, Institute for Molecular Plant Physiology and Biophysics, Julius von Sachs Platz 2, D 97082 Wuerzburg, Germany
    Plant J 68:129-36. 2011
    ..Some members of the SUC family are plasma membrane proton/sucrose symporters...
  8. doi The sucrose transporter family in Populus: the importance of a tonoplast PtaSUT4 to biomass and carbon partitioning
    Raja S Payyavula
    School of Forest Resources and Environmental Sciences, Michigan Technological University, Houghton, MI 49931, USA
    Plant J 65:757-70. 2011
    Plasma membrane, proton-coupled Group II sucrose symporters (SUT) mediate apoplastic phloem loading and sucrose efflux from source leaves in Arabidopsis and agricultural crop species that have been studied to date...
  9. doi The effects of long-term honey, sucrose or sugar-free diets on memory and anxiety in rats
    Lynne M Chepulis
    Department of Biological Sciences, Waikato University, Hamilton, New Zealand
    Physiol Behav 97:359-68. 2009
    b>Sucrose is considered by many to be detrimental to health, giving rise to deterioration of the body associated with ageing...
  10. pmc The Arabidopsis plastid-signalling mutant gun1 (genomes uncoupled1) shows altered sensitivity to sucrose and abscisic acid and alterations in early seedling development
    Amanda Cottage
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    J Exp Bot 61:3773-86. 2010
    ..gun1 seedlings accumulated less anthocyanin than wild-type seedlings when grown in the presence of 2% (w/v) sucrose, due to lower amounts of transcripts of early anthocyanin biosynthesis genes in gun1...
  11. doi The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats
    Bianca Jupp
    Florey Neuroscience Institutes, Parkville, Victoria 3010, Australia
    Brain Res 1391:54-9. 2011
    ..schedules of reinforcement, and whether this differs from the motivation to administer a natural food reward, sucrose (0.2-0.7% w/v) in alcohol preferring (iP) rats...
  12. ncbi Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
    Zhenyuan Song
    Dept of Medicine, Univ of Louisville Medical Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 293:G894-902. 2007
    ..In this study, we examined the effects of betaine on fat accumulation in the liver induced by high-sucrose diet and evaluated mechanisms by which betaine could attenuate or prevent hepatic steatosis in this model...
  13. pmc Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression
    Karolina P Skibicka
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden
    Addict Biol 17:95-107. 2012
    ..for natural sugar reward by examining the role of ghrelin receptor (GHS-R1A) stimulation and blockade for sucrose progressive ratio operant conditioning, a procedure used to measure motivational drive to obtain a reward...
  14. ncbi MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes
    Oliver Thimm
    Max Planck Institute for Molecular Plant Physiology, Golm, Germany
    Plant J 37:914-39. 2004
    ....
  15. doi Sucrose synthase is an integral component of the cellulose synthesis machinery
    Satoshi Fujii
    Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, 560 0043 Japan f
    Plant Cell Physiol 51:294-301. 2010
    ..to as the catalytic unit of cellulose synthesis, was enriched with a 78 kDa polypeptide which was verified as sucrose synthase like by mass spectrometry and immunoblotting...
  16. ncbi Temporal analysis of sucrose-induced phosphorylation changes in plasma membrane proteins of Arabidopsis
    Totte Niittyla
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Mol Cell Proteomics 6:1711-26. 2007
    b>Sucrose is the main product of photosynthesis and the most common transport form of carbon in plants. In addition, sucrose is a compound that serves as a signal affecting metabolic flux and development...
  17. doi Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases
    Diana V Dugas
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
    Plant Mol Biol 67:403-17. 2008
    ..Here we show that miR398 is positively regulated by sucrose, resulting in decreased CSD1 and CSD2 mRNA and protein accumulation...
  18. ncbi Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
    Dongfeng Cao
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 282:36275-82. 2007
    ..In the present study, we provided 10% sucrose-sweetened water to a transgenic mouse model of AD with a normal rodent diet...
  19. doi Hexoses as phloem transport sugars: the end of a dogma?
    Aart J E van Bel
    Plant Cell Biology Research Group, Institute of General Botany, Justus Liebig University, Senckenbergstrasse 17, D 35390 Giessen, Germany
    J Exp Bot 59:261-72. 2008
    According to most textbooks, only non-reducing carbohydrate species such as sucrose, sugar alcohols, and raffinose-family sugars function as phloem translocates...
  20. doi Sugarcane for bioenergy production: an assessment of yield and regulation of sucrose content
    Alessandro J Waclawovsky
    Departamento de Bioquimica, Instituto de Quimica, Av Prof Lineu Prestes, Sao Paulo, Brazil
    Plant Biotechnol J 8:263-76. 2010
    ..The most important biofuel to date is bioethanol produced from sugars (sucrose and starch)...
  21. doi Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood-brain barrier in vitro and their influence on barrier integrity
    Ralf Rempe
    Department of Biochemistry, University of Muenster, Wilhelm Klemm Strasse 2, D 48149 Muenster, Germany
    Biochem Biophys Res Commun 406:64-9. 2011
    ..the integrity of the BBB in vitro was verified by measuring the passage of the reference substances (14)C-sucrose and FITC-BSA after addition of PBCA-NP...
  22. pmc A new subfamily of sucrose transporters, SUT4, with low affinity/high capacity localized in enucleate sieve elements of plants
    A Weise
    Plant Physiology, Zentrum für Molekularbiologie der Pflanzen, University of Tubingen, D 72076 Tubingen, Germany
    Plant Cell 12:1345-55. 2000
    A new subfamily of sucrose transporters from Arabidopsis (AtSUT4), tomato (LeSUT4), and potato (StSUT4) was isolated, demonstrating only 47% similarity to the previously characterized SUT1...
  23. ncbi Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress
    Stéphanie Pothion
    Key Obs SA, Parc Technologique, 3 allée du Titane, 16 rue Leonard de Vinci, 45100 Orleans, France
    Behav Brain Res 155:135-46. 2004
    ..These strains were chosen among 11 strains that were tested in a first experiment for their sucrose consumption and preference for sucrose solutions of different concentrations...
  24. ncbi Sucrose-mediated priming of plant defense responses and broad-spectrum disease resistance by overexpression of the maize pathogenesis-related PRms protein in rice plants
    Jorge Gómez-Ariza
    Departamento de Genetica Molecular, Laboratório de Genética Molecular Vegetal, Consorcio CSIC IRTA, Jordi Girona 18, 08034 Barcelona, Spain
    Mol Plant Microbe Interact 20:832-42. 2007
    ..We also have found that sucrose accumulates at higher levels in leaves of PRms plants...
  25. ncbi The potato sucrose transporter StSUT1 interacts with a DRM-associated protein disulfide isomerase
    Undine Krügel
    Institute of Biology, Department of Plant Physiology, Humboldt University, 10115 Berlin, Germany
    Mol Plant 5:43-62. 2012
    ..We used the yeast two-hybrid split ubiquitin system (SUS) to systematically screen for interaction between the sucrose transporter StSUT1 and other membrane-associated or soluble proteins in vivo...
  26. pmc Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mechanism linking starch synthesis to the sucrose supply
    Axel Tiessen
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Cell 14:2191-213. 2002
    ..Furthermore, activation of AGPase resulted in a stimulation of starch synthesis and decreased levels of glycolytic intermediates...
  27. doi Functional analysis of sucrose phosphate synthase (SPS) and sucrose synthase (SS) in sugarcane (Saccharum) cultivars
    A K Verma
    U P Council of Sugarcane Research, Shahjahanpur, India
    Plant Biol (Stuttg) 13:325-32. 2011
    b>Sucrose phosphate synthase (SPS; EC 2.4.1.14) and sucrose synthase (SS; EC 2.4.1.13) are key enzymes in the synthesis and breakdown of sucrose in sugarcane...
  28. pmc Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets
    Fanny Ramel
    Centre National de la Recherche Scientifique, Universite de Rennes I, UMR 6553 Ecobio, Campus de Beaulieu, Bâtiment 14A, F 35042, Rennes Cedex, France
    BMC Plant Biol 9:28. 2009
    ..b>Sucrose has been shown to confer to Arabidopsis seedlings a high level of tolerance to the herbicide atrazine, which ..
  29. pmc Daylength and circadian effects on starch degradation and maltose metabolism
    Yan Lu
    Department of Botany, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Physiol 138:2280-91. 2005
    ..Light is necessary for the cycling of transcript levels and maltose levels. Under continuous darkness, these genes were barely expressed, and no cycling of maltose levels was observed...
  30. pmc Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila
    Yuchen Jiao
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 18:1797-801. 2008
    ..Disruption of Gr5a prevents the detection of trehalose [1-3], whereas mutation of Gr64a impairs the responses to sucrose, maltose, and glucose [4, 5]...
  31. pmc Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking
    Pia Steensland
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 104:12518-23. 2007
    ..administration of varenicline, in doses reported to reduce nicotine reward, selectively reduced ethanol but not sucrose seeking using an operant self-administration drinking paradigm and also decreased voluntary ethanol but not water ..
  32. doi Sucrose transporter NtSUT4 from tobacco BY-2 involved in plant cell shape during miniprotoplast culture
    Emiko Okubo-Kurihara
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha 5 1 5, Kashiwa, Chiba, 277 8562, Japan
    J Plant Res 124:395-403. 2011
    b>Sucrose plays an important role in several cellular processes since it is a general source of metabolic energy, serves as a precursor for starch and cellulose synthesis, and is a metabolic starting point for carboxylate- and amino acid ..
  33. pmc Downregulation of pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase activity in sugarcane culms enhances sucrose accumulation due to elevated hexose-phosphate levels
    Margaretha J van der Merwe
    Institute of Plant Biotechnology, University of Stellenbosch, Merriman Avenue, Stellenbosch 7602, South Africa
    Planta 231:595-608. 2010
    ..In three independent transgenic lines, sucrose concentrations increased between three- and sixfold in immature internodes, compared to the levels in the ..
  34. ncbi Restricted access to food, but not sucrose, saccharine, or salt, synchronizes the expression of Period2 protein in the limbic forebrain
    E Waddington Lamont
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, Quebec, Canada
    Neuroscience 144:402-11. 2007
    ..Daily limited access to sucrose or saccharine in freely fed rats or scheduled access to saline in sodium-deprived rats had no effect on these ..
  35. ncbi Sucrose metabolism: regulatory mechanisms and pivotal roles in sugar sensing and plant development
    Karen Koch
    Plant Molecular and Cellular Biology Program, Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, USA
    Curr Opin Plant Biol 7:235-46. 2004
    b>Sucrose cleavage is vital to multicellular plants, not only for the allocation of crucial carbon resources but also for the initiation of hexose-based sugar signals in importing structures...
  36. doi Alterations of sucrose preference after Roux-en-Y gastric bypass
    M Bueter
    Department of Investigative Medicine, Imperial Weight Centre, Imperial College London, London, UK
    Physiol Behav 104:709-21. 2011
    ..This study aimed to further investigate alterations in sweet food intake in rats and sucrose detection in humans after gastric bypass...
  37. pmc Protection of SH-SY5Y neuronal cells from glutamate-induced apoptosis by 3,6'-disinapoyl sucrose, a bioactive compound isolated from Radix Polygala
    Yuan Hu
    Department of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China
    J Biomed Biotechnol 2012:1-5. 2012
    The neuroprotective effects of 3,6'-disinapoyl sucrose (DISS) from Radix Polygala against glutamate-induced SH-SY5Y neuronal cells injury were evaluated in the present study...
  38. pmc The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 108:5104-9. 2011
    ..Here we report sensitivity of the Arabidopsis thaliana circadian oscillator to sucrose, providing evidence that plant metabolism can regulate circadian function...
  39. pmc Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression
    Marcus A Lawson
    Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:1569-75. 2011
    ..Furthermore, adult C57BL/6J mice injected with Tat and tested in a two-bottle 1% sucrose preference test displayed reduced preference for sucrose during the 24 h post-injection period...
  40. pmc Sucrose metabolism contributes to in vivo fitness of Streptococcus pneumoniae
    Ramkumar Iyer
    Howard Hughes Medical Institute, Tufts University, Boston, MA 02110, USA
    Mol Microbiol 66:1-13. 2007
    We characterized two sucrose-metabolizing systems -sus and scr- and describe their roles in the physiology and virulence of Streptococcus pneumoniae in murine models of carriage and pneumonia...
  41. doi Sensing embolism in xylem vessels: the role of sucrose as a trigger for refilling
    Francesca Secchi
    Arnold Arboretum of Harvard University, BioLabs 3114, 16 Dinivity Ave, Cambridge, MA 02138, USA
    Plant Cell Environ 34:514-24. 2011
    ..Analysis of Populus trichocarpa's response to infiltration of sucrose, monosaccharides, polyethylene glycol and potassium chloride into the xylem revealed that only presence of ..
  42. doi Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum
    Xiongzhao Zhu
    Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Behav Brain Res 223:329-35. 2011
    ..This process is associated with down-regulated Par-4 and DRD2 gene expression in the striatum through a non-methylation mechanism...
  43. doi Identification of an animal sucrose transporter
    Heiko Meyer
    Department of Biology and Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Cell Sci 124:1984-91. 2011
    ..Here, we present the first report of an animal sucrose transporter, SCRT, which we detected in Drosophila melanogaster at each developmental stage...
  44. doi Screening of valid reference genes for real-time RT-PCR data normalization in Hevea brasiliensis and expression validation of a sucrose transporter gene HbSUT3
    Heping Li
    Key Lab of Rubber Biology, Ministry of Agriculture and Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan 571737, China
    Plant Sci 181:132-9. 2011
    ..In addition, examination of relative expression of a sucrose transporter HbSUT3 in different RNA samples demonstrated the importance of additional reference genes to ensure ..
  45. ncbi Doubled sugar content in sugarcane plants modified to produce a sucrose isomer
    Luguang Wu
    Botany Department SIB, The University of Queensland, Brisbane, QLD 4072, Australia
    Plant Biotechnol J 5:109-17. 2007
    b>Sucrose is the feedstock for more than half of the world's fuel ethanol production and a major human food. It is harvested primarily from sugarcane and beet...
  46. doi Metabolism of soluble sugars in developing melon fruit: a global transcriptional view of the metabolic transition to sucrose accumulation
    Nir Dai
    Institute of Plant Science, Agricultural Research Organization, Bet Dagan, Israel
    Plant Mol Biol 76:1-18. 2011
    ..by a metabolic transition during its development that leads to extensive accumulation of the disaccharide sucrose in the mature fruit...
  47. pmc Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues
    James E McCutcheon
    Department of Psychology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Synapse 66:346-51. 2012
    ..sweetener (saccharin) would evoke similar dopamine release as cues paired with a nutritive sweetener (sucrose). We trained food-restricted rats to associate distinct cues with sucrose or saccharin pellets...
  48. pmc Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats
    Suzie Hong
    Department of Anesthesiology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, United States
    Physiol Behav 105:269-75. 2012
    ..Dawley rats on behavior in the forced swim test at the end of adolescence and in adulthood and on behavior in the sucrose preference test in adulthood...
  49. pmc Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
    Mitchell F Roitman
    Department of Psychology, University of Illinois, Chicago, Illinois 60607, USA
    Nat Neurosci 11:1376-7. 2008
    ..This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry...
  50. doi AKINbeta1 is involved in the regulation of nitrogen metabolism and sugar signaling in Arabidopsis
    Xiao Fang Li
    School of Life Sciences, East China Normal University, Shanghai 200062, China
    J Integr Plant Biol 51:513-20. 2009
    b>Sucrose non-fermenting-1-related protein kinase 1 (SnRK1) has been located at the heart of the control of metabolism and development in plants. The active SnRK1 form is usually a heterotrimeric complex...
  51. ncbi Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 7:100-7. 2004
    ..g of dextrose or 90 g of honey on PGL in seven patients with type 2 diabetes mellitus; and (7) effects of 30 g of sucrose or 30 g of honey on PGL, plasma insulin, and plasma C-peptide in five diabetic patients...
  52. ncbi Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Pediatrics 116:921-6. 2005
    ..We chose to examine sucrose, cola drink, honey, human milk, cow milk, and water because some of these have been associated with development ..
  53. pmc Mrt, a gene unique to fungi, encodes an oligosaccharide transporter and facilitates rhizosphere competency in Metarhizium robertsii
    Weiguo Fang
    Department of Entomology, University of Maryland, College Park, Maryland 20742, USA
    Plant Physiol 154:1549-57. 2010
    ..Here, we demonstrate that sucrose and raffinose family oligosaccharides in root exudates are important for rhizosphere competence in the insect ..
  54. ncbi A flux model of glycolysis and the oxidative pentosephosphate pathway in developing Brassica napus embryos
    Jorg Schwender
    Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:29442-53. 2003
    Developing oilseeds synthesize large quantities of triacylglycerol from sucrose and hexose...
  55. doi Prospects for increasing starch and sucrose yields for bioethanol production
    Alison M Smith
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 54:546-58. 2008
    ..b>Sucrose accumulation is much less well understood than starch synthesis, but recent results from research on sugar cane ..
  56. pmc ADP-glucose pyrophosphorylase is activated by posttranslational redox-modification in response to light and to sugars in leaves of Arabidopsis and other plant species
    Janneke H M Hendriks
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:838-49. 2003
    ..AGPB is converted from a dimer to monomer when sucrose is supplied to leaves via the petiole in the dark...
  57. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
    The combination of sucrose and starch in the presence of surface-adsorbed salivary α-amylase and bacterial glucosyltransferases increase the formation of a structurally and metabolically distinctive biofilm by Streptococcus mutans...
  58. pmc Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis
    Mingguang Lei
    Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Plant Physiol 156:1116-30. 2011
    ..Molecular and genetic analyses indicated that the mutant phenotype is caused by overexpression of the SUCROSE TRANSPORTER2 (SUC2) gene...
  59. ncbi Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system
    D Hoheisel
    Institut fur Biochemie, Westfalische Wilhelms Universitat, Munster, Germany
    Biochem Biophys Res Commun 247:312-5. 1998
    ..In correspondence to the TER increase hydrocortisone decreased cell monolayer permeability for sucrose down to 5x10(-7) cm/s, which is close to the in vivo value of 1...
  60. pmc Three Drosophila mutations that block associative learning also affect habituation and sensitization
    J S Duerr
    Proc Natl Acad Sci U S A 79:3646-50. 1982
    ..Fruit flies have taste receptors on their feet. When a starved, water-satiated fly has sucrose applied to one foot, it usually responds by extending its proboscis...
  61. ncbi Clinical outcome of oocyte cryopreservation after slow cooling with a protocol utilizing a high sucrose concentration
    A Borini
    Tecnobios Procreazione, Via Dante 15 University of Bologna, 40125 Bologna, Italy
    Hum Reprod 21:512-7. 2006
    ..However, the clinical efficiency of these protocols has not been exhaustively explored and therefore remains controversial...
  62. doi Resistance to the two-spotted spider mite (Tetranychus urticae) by acylsucroses of wild tomato (Solanum pimpinellifolium) trichomes studied in a recombinant inbred line population
    Juan Manuel Alba
    Estacion Experimental La Mayora CSIC, Algarrobo Costa, 29760, Malaga, Spain
    Exp Appl Acarol 47:35-47. 2009
    ..Altogether, these results indicate that S. pimpinellifolium may be a suitable genetic source of resistance to spider mites to be used in cultivated tomato...
  63. ncbi Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism
    Helen Pinfield-Wells
    CNAP, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Plant J 43:861-72. 2005
    ..In acx1-1 and acx2-1, seedling growth and establishment in the absence of an exogenous supply of sucrose was unaffected...
  64. doi The sucrose transporter HbSUT3 plays an active role in sucrose loading to laticifer and rubber productivity in exploited trees of Hevea brasiliensis (para rubber tree)
    Chaorong Tang
    Key Lab of Rubber Biology, Ministry of Agriculture and Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, College of Agronomy, Hainan University, Danzhou, Hainan 571737, China
    Plant Cell Environ 33:1708-20. 2010
    Efficient sucrose loading in rubber-producing cells (laticifer cells) is essential for retaining rubber productivity in Hevea brasiliensis, but the molecular mechanisms underlying the regulation of this process remain unknown...
  65. ncbi Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose
    D Forst
    Institut fur Biophysik und Strahlenbiologie, Albert Ludwigs Universitat, Freiburg im Breisgau, Germany
    Nat Struct Biol 5:37-46. 1998
    The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose...
  66. ncbi Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs
    Luca Cucullo
    Center for Cerebrovascular Research, Cleveland, Ohio, USA
    Epilepsia 48:505-16. 2007
    ....
  67. pmc Beneficial effects of exercise and its molecular mechanisms on depression in rats
    Hang Zheng
    West China Medical Center, Sichuan University, Chengdu, Sichuan 610041, PR China
    Behav Brain Res 168:47-55. 2006
    ..Stressed rats consumed significantly less of a 1% sucrose solution during CNS and exhibited a significant decrease in open field behavior...
  68. ncbi Temporal responses of transcripts, enzyme activities and metabolites after adding sucrose to carbon-deprived Arabidopsis seedlings
    Daniel Osuna
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant J 49:463-91. 2007
    Arabidopsis seedlings were subjected to 2 days of carbon starvation, and then resupplied with 15 mm sucrose. The transcriptional and metabolic response was analyzed using ATH1 arrays, real-time quantitative (q)RT-PCR analysis of >2000 ..
  69. ncbi Sucrose to starch: a transition in molecular plant physiology
    Alisdair R Fernie
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Trends Plant Sci 7:35-41. 2002
    The major flux in potato tuber carbon metabolism is the conversion of sucrose through hexose phosphates to starch...
  70. pmc Differential effects of sucrose and auxin on localized phosphate deficiency-induced modulation of different traits of root system architecture in Arabidopsis
    Ajay Jain
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 1165, USA
    Plant Physiol 144:232-47. 2007
    ..Here, we present the differential effects of sucrose (Suc) and auxin on the Pi deficiency responses of the primary and lateral roots of Arabidopsis (Arabidopsis ..
  71. ncbi Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance
    Michael J Pagliassotti
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Endocrinol Metab 282:E170-6. 2002
    b>Sucrose feeding reduces the ability of insulin to suppress glucose production and hepatic gluconeogenesis. The present study examined the effect of a high-sucrose diet on early insulin-signaling steps in the liver...
  72. doi Sucrose transport in the phloem: integrating root responses to phosphorus starvation
    John P Hammond
    Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, UK
    J Exp Bot 59:93-109. 2008
    ..Photosynthate is primarily transported to sink tissues as sucrose via the phloem. Under phosphorus (P) starvation, plants accumulate sugars and starch in their leaves...
  73. ncbi Expression of biofilm-associated genes of Streptococcus mutans in response to glucose and sucrose
    Moshe Shemesh
    Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University Hadassah, POB 12272, Jerusalem 91120, Israel
    J Med Microbiol 56:1528-35. 2007
    ..In spite of a significant upregulation in biofilm-associated gene expression in the presence of sucrose, the presence of glucose with sucrose reduced expression of most tested genes...
  74. ncbi Oral sucrose stimulation increases accumbens dopamine in the rat
    Andras Hajnal
    Department of Neural and Behavioral Sciences H181, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 286:R31-7. 2004
    ..from possible postingestive consequences, we investigated the quantitative relationship between sham feeding of sucrose and extracellular dopamine in the nucleus accumbens with microdialysis in rats...
  75. doi Analgesic properties of oral sucrose during routine immunizations at 2 and 4 months of age
    Linda A Hatfield
    Pennsylvania State University School of Nursing, College of Health and Human Development, 307B HHD East, University Park, PA 16802, USA
    Pediatrics 121:e327-34. 2008
    The purpose of this work was to evaluate the analgesic properties of oral sucrose during routine immunizations in infants at 2 and 4 months of age.
  76. ncbi Long-term dietary compensation for added sugar: effects of supplementary sucrose drinks over a 4-week period
    Marie Reid
    Psychology Department, Queen Margaret University College, Edinburgh, UK
    Br J Nutr 97:193-203. 2007
    ..Subjects were categorised as 'watchers' or 'non-watchers' of what they ate then received sucrose or artificially sweetened drinks (4 x 250 ml per d)...
  77. pmc Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism
    Renate Müller
    Plant Biochemistry Laboratory, Department of Plant Biology, Royal Veterinary and Agricultural University, DK 1871 Frederiksberg C, Denmark
    Plant Physiol 143:156-71. 2007
    ..Leaf segments derived from phosphorus (P)-starved and P-replenished plants were incubated with or without sucrose (Suc) to obtain tissues with contrasting combinations of P and carbohydrate levels...
  78. ncbi Breastfeeding or oral sucrose solution in term neonates receiving heel lance: a randomized, controlled trial
    Luigi Codipietro
    ASL 10 Agnelli Hospital, Stradale Fenestrelle 72, Pinerolo 10064, Italy
    Pediatrics 122:e716-21. 2008
    The purpose of this work was to compare the efficacy of breastfeeding versus orally administered sucrose solution in reducing pain response during blood sampling through heel lance...
  79. ncbi Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze-dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling
    B van Eerdenbrugh
    Laboratory for Pharmacotechnology and Biopharmacy, K U Leuven, Gasthuisberg O and N2, Herestraat 49, box 921, 3000 Leuven, Belgium
    Int J Pharm 338:198-206. 2007
    In order to improve the dissolution and absorption properties of loviride, a poorly soluble antiviral agent, sucrose co-freeze-dried nanopowders were prepared, characterized and evaluated...
  80. ncbi Evidence-based review of oral sucrose administration to decrease the pain response in newborn infants
    Kathleen H Leef
    Neonatal Intensive Care Unit, Christiana Care Health Services, Newark, Delaware, USA
    Neonatal Netw 25:275-84. 2006
    ..This article reviews the evidence regarding the safety and efficacy of oral sucrose administration, to help answer the clinical question of how to manage an infant's pain response to minor invasive ..
  81. pmc Effects of sucrose on the extracellular matrix of plaque-like biofilm formed in vivo, studied by proteomic analysis
    A F Paes Leme
    Piracicaba Dental School, UNICAMP, Piracicaba, Brazil
    Caries Res 42:435-43. 2008
    Previous studies have shown that sucrose promotes changes in the composition of the extracellular matrix (ECM) of plaque-like biofilm (PLB), but its effect on protein expression has not been studied in vivo...
  82. ncbi Increased sucrose level and altered nitrogen metabolism in Arabidopsis thaliana transgenic plants expressing antisense chloroplastic fructose-1,6-bisphosphatase
    Mariam Sahrawy
    Department of Biochemistry, Cell and Molecular Biology of Plants, Estacion Experimental del Zaidin, Prof Albareda 1, 18008 Granada, Spain
    J Exp Bot 55:2495-503. 2004
    ..Decreased FBPase activity boosted the foliar carbohydrate contents, with a shift in the sucrose:starch ratio, which reached a maximum of 0.99 when the activity loss was 41%...
  83. pmc Distribution of callose synthase, cellulose synthase, and sucrose synthase in tobacco pollen tube is controlled in dissimilar ways by actin filaments and microtubules
    Giampiero Cai
    Dipartimento Scienze Ambientali G Sarfatti, Universita di Siena, 53100 Siena, Italy
    Plant Physiol 155:1169-90. 2011
    ..Callose synthase also comigrates with tubulin by Blue Native-polyacrylamide gel electrophoresis. Membrane sucrose synthase, which expectedly provides UDP-glucose to callose synthase and cellulose synthase, binds to actin ..
  84. ncbi High sucrose intake in rats is associated with increased ACE2 and angiotensin-(1-7) levels in the adipose tissue
    Michella Soares Coelho
    Department of Internal Medicine, Laboratory of Experimental Hypertension of the University of São Paulo School of Medicine, Brazil
    Regul Pept 162:61-7. 2010
    b>Sucrose-fed rats, a model of metabolic syndrome, are characterized by insulin resistance, obesity, hypertension, and high plasma levels of triacylglycerols and angiotensin II (Ang II)...
  85. pmc Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial
    Rebeccah Slater
    Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK
    Lancet 376:1225-32. 2010
    Many infants admitted to hospital undergo repeated invasive procedures. Oral sucrose is frequently given to relieve procedural pain in neonates on the basis of its effect on behavioural and physiological pain scores...
  86. pmc Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis
    Almudena Lomba
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Lipids Health Dis 9:60. 2010
    ..regulation of gene expression and with obesity development, we investigated the effects on methylation and expression patterns of two pair-fed isocaloric diets in rats: control (rich in starch) and HFS (rich in fat and sucrose).
  87. pmc NTRC links built-in thioredoxin to light and sucrose in regulating starch synthesis in chloroplasts and amyloplasts
    Justyna Michalska
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Proc Natl Acad Sci U S A 106:9908-13. 2009
    ..In leaves, AGPase was activated in planta either by light or external feeding of sucrose in the dark...
  88. ncbi Evidence that SNF1-related kinase and hexokinase are involved in separate sugar-signalling pathways modulating post-translational redox activation of ADP-glucose pyrophosphorylase in potato tubers
    Axel Tiessen
    Max Planck Institute of Molecular Plant Physiology, 14476 Golm, Germany
    Plant J 35:490-500. 2003
    ..AGPase) is a powerful new mechanism to adjust the rate of starch synthesis to the availability of sucrose in growing potato tubers...
  89. ncbi Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans
    Lin Zhu
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Microbiology 152:2395-404. 2006
    ..More interestingly, these phenotypic differences diminished as sucrose concentration in the medium was increased to 0.5 %...
  90. ncbi Biochemical composition and cariogenicity of dental plaque formed in the presence of sucrose or glucose and fructose
    J A Cury
    Faculty of Dentistry of Piracicaba, State University of Campinas, SP, Brazil
    Caries Res 34:491-7. 2000
    The composition of dental plaque formed in the presence of sucrose or glucose and fructose and its relation to cariogenicity was evaluated. Twelve adult volunteers took part in this crossover study done in three phases of 28 days each...
  91. ncbi Protection mechanisms in the resurrection plant Xerophyta viscosa (Baker): both sucrose and raffinose family oligosaccharides (RFOs) accumulate in leaves in response to water deficit
    Shaun Peters
    University of Cape Town, Department of Molecular and Cell Biology, Private Bag, Rhodes Gift, 7701, Cape Town, South Africa
    J Exp Bot 58:1947-56. 2007
    ..b>Sucrose and raffinose family oligosaccharides (RFOs), particularly raffinose, increased under these conditions, with the ..
  92. doi Role of sucrose in the fitness of Streptococcus mutans
    J Kreth
    School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Oral Microbiol Immunol 23:213-9. 2008
    Dental caries has been closely linked to fermentable carbohydrates as key environmental factors. Sucrose has been identified as the most cariogenic carbohydrate...
  93. ncbi Human oocyte cryopreservation: new perspectives regarding oocyte survival
    R Fabbri
    IVF Center, Human Reproductive Medicine Unit, Institute of Obstetrics and Gynecology, University of Bologna, 40138 Bologna, Italy
    Hum Reprod 16:411-6. 2001
    ..Therefore the effect of some factors, such as the presence or absence of the cumulus oophorus, the sucrose concentration in the freezing solution and the exposure time to cryoprotectants, on human oocyte survival after ..
  94. doi Adipose tissue, liver and pancreas structural alterations in C57BL/6 mice fed high-fat-high-sucrose diet supplemented with fish oil (n-3 fatty acid rich oil)
    Fernanda A M Nascimento
    Laboratorio de Morfometria e Morfologia Cardiovascular, Centro Biomedico, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av 28 de Setembro 87 fds 20551 030 Rio de Janeiro, RJ, Brasil
    Exp Toxicol Pathol 62:17-25. 2010
    Fish oil treatment was used in reversing the morphological and metabolic changes of C57BL/6 mice fed high-fat-high-sucrose (HFHS) diet. Two-month-old male C57BL/6 mice were fed HFHS chow or standard chow (SC)...
  95. ncbi Effect of starch on the cariogenic potential of sucrose
    Cecilia C C Ribeiro
    Faculty of Dentistry of Piracicaba, University of Campinas, Av Limeira 901, CEP 13414 903, Piracicaba, Sao Paulo, Brazil
    Br J Nutr 94:44-50. 2005
    Since in vitro and animal studies suggest that the combination of starch with sucrose may be more cariogenic than sucrose alone, the study assessed in situ the effects of this association applied in vitro on the acidogenicity, ..
  96. doi Sucrose, sucrosyl oligosaccharides, and oxidative stress: scavenging and salvaging?
    Wim Van den Ende
    Laboratory for Molecular Plant Physiology, KU Leuven, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
    J Exp Bot 60:9-18. 2009
    ..They are believed to act as important membrane protectors in planta. So far a putative role for sucrose and SOS during oxidative stress has largely been neglected, as has the contribution of the vacuolar compartment...
  97. ncbi Molecular physiology of higher plant sucrose transporters
    Norbert Sauer
    Molekulare Pflanzenphysiologie, FAU Erlangen Nürnberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    FEBS Lett 581:2309-17. 2007
    b>Sucrose is the primary product of photosynthetic CO(2) fixation that is used for the distribution of assimilated carbon within higher plants...
  98. doi Effects of sucrose, glucose and fructose on peripheral and central appetite signals
    Andreas Lindqvist
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Regul Pept 150:26-32. 2008
    ..Soft drinks, originally sweetened by sucrose, are now sweetened by other caloric sweeteners, such as fructose...
  99. pmc The protein kinase SnRK2.6 mediates the regulation of sucrose metabolism and plant growth in Arabidopsis
    Zhifu Zheng
    Dow AgroSciences LLC, Indianapolis, Indiana 46268, USA
    Plant Physiol 153:99-113. 2010
    In higher plants, three subfamilies of sucrose nonfermenting-1 (Snf1)-related protein kinases have evolved...
  100. pmc Sucrose synthase affects carbon partitioning to increase cellulose production and altered cell wall ultrastructure
    Heather D Coleman
    Department of Wood Science, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Proc Natl Acad Sci U S A 106:13118-23. 2009
    Overexpression of the Gossypium hirsutum sucrose synthase (SuSy) gene under the control of 2 promoters was examined in hybrid poplar (Populus alba x grandidentata)...
  101. ncbi Decreased expression of two key enzymes in the sucrose biosynthesis pathway, cytosolic fructose-1,6-bisphosphatase and sucrose phosphate synthase, has remarkably different consequences for photosynthetic carbon metabolism in transgenic Arabidopsis thalian
    A Strand
    Umea Plant Science Centre, Department of Plant Physiology, Umea University, S 901 87 Umea, Sweden
    Plant J 23:759-70. 2000
    Photosynthetic carbon metabolism was investigated in antisense Arabidopsis lines with decreased expression of sucrose phosphate synthase (SPS) and cytosolic fructose-1,6-bisphosphatase (cFBPase)...

Research Grants75

  1. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2009
    ..of specific expectation: the first task, a go/no-go in which one tone cues the availability of a palatable taste (sucrose or NaCl) and the other a punishment (quinine) at a press of a lever, will reveal the effects of expectation of ..
  2. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
    ..g., sucrose), intracranial self-stimulation (ICSS) and cocaine self-administration...
  3. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  4. STRUCTURE, BIOSYNTHESIS AND FUNCTION OF GLYCOPROTEINS
    Stuart Kornfeld; Fiscal Year: 2007
    ..in hand, the effect of phosphorylation on the conformation of GGAs 1/3 will be studied by gel filtration, sucrose density gradients and protease sensitivity...
  5. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..based on the physical and coagulation properties of a mixture of Teleostan Gelatin type A, Polyvinylpyrrolidone, Sucrose and Fibrinogen, with a water-soluble foam inducer; the addition of thrombin and P-selectin inmunoglobin chimera, ..
  6. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..In Specific Aim 1, interaction of drugs with excipients such as sweeteners (e.g., saccharin, sucralose, sucrose) and diluents/binder (e.g., microcrystalline cellulose, dicalcium phosphate) will be examined...
  7. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..Dental caries is initiated by increased prevalence of mutans streptococci, which metabolize sucrose to lactic acid and create an acidic local environment that demineralizes tooth enamel and causes tooth decay...
  8. Nutrition and Physical Activity Assessment Study (NPAAS)
    ROSS L contact PRENTICE; Fiscal Year: 2010
    ..We will obtain 24-h urine-derived nutritional measures, including nitrogen (protein), fructose, sucrose (sugars), alkylresorcinols (whole grains) and 1- and 3- methylhistidine (meat);and blood-derived nutritional ..
  9. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry E Levin; Fiscal Year: 2010
    ..glucoprivic feeding but lowering it had no effect on energy homeostasis or glucose tolerance in rats fed low, low sucrose diets...
  10. Pain and Hypoxia in Premature Neonates
    DANILYN ANGELES; Fiscal Year: 2009
    ..Premature infants experiencing heel lance will be randomized into either a placebo or sucrose intervention group...
  11. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2010
    ..Premature infants experiencing heel lance will be randomized into either a placebo or sucrose intervention group...
  12. Gustatory Control of Sodium Appetite
    Ralph Norgren; Fiscal Year: 2010
    ..We use the release of dopamine (DA) in the nucleus accumbens as a forebrain index of reward. Sham licking sucrose produces a substantial efflux of accumbens DA even in experienced animals...
  13. Streptococcus mutans sugar transport & biofilm formation
    Dragana Ajdic; Fiscal Year: 2003
    ..transporters and fourteen PTS systems for the probable transport of sugars or sugar alcohols including glucose, sucrose, maltose, lactose and fructose...
  14. BIOSYNTHETIC STUDY OF DENTAL PLAQUE POLYSACCHARIDES
    JOHN ROBYT; Fiscal Year: 1991
    ..The study will focus on five aspects: (1) The study of the sucrose binding specificity...
  15. REGULATION OF CARBOHYDRATE DIGESTION
    Gary Gray; Fiscal Year: 1991
    ..Paired intestinal segments from animals fed a carbohydrate-free diet for 7 days will be perfused with either sucrose plus saline or saline alone and then given a 5 minute intraintestinal pulse of 35S-methionine followed by a non-..
  16. PROTEIN PHOSPHORYLATION IN SPERM FLAGELLAR MOTILITY
    JOSEPH TASH; Fiscal Year: 1991
    ..phosphatase was differentially salt-extracted from flagella and dynein and could be reversibly co-sedimented into sucrose gradients with 21S dynein. The phosphatase regulates Ca2+ -dependent swimming parameters in sperm models...
  17. ORAL STREPTOCOCCAL VIRULENCE--NEW MOLECULAR APPROACHES
    DONALD LEBLANC; Fiscal Year: 1990
    ..DNA technology and transposon mutagenesis will be used to examine, directly in oral streptococci, the pathways of sucrose metabolism by Streptococcus mutans...
  18. Gustatory Control of Sodium Appetite
    Ralph Norgren; Fiscal Year: 2009
    ..We use the release of dopamine (DA) in the nucleus accumbens as a forebrain index of reward. Sham licking sucrose produces a substantial efflux of accumbens DA even in experienced animals...
  19. Substrate Selection in Homologous Bacterial Transporters
    Manuel Varela; Fiscal Year: 2004
    ..coli (LacY) also confer sugar selection in homologous transporters for melibiose (MelY), raffinose (RafB) and sucrose (CseB)...
  20. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
    ..g., sucrose), intracranial self-stimulation (ICSS) and cocaine self-administration...
  21. PROCESSING OF TASTE MIXTURES BY BRAINSTEM NEURONS
    David Smith; Fiscal Year: 1990
    ..Stimuli will be concentration series of sucrose NaCl, citric acid, and quinine hydrochloride (QHCl) and their mixtures (heterogeneous) and sucrose, fructose, ..
  22. NUTRITIONAL EFFECTS OF SUGARS ON LIVER LIPIDS
    CHARLES SPARKS; Fiscal Year: 1990
    ..In rabbits fed semi-purified diets, sucrose as a carbohydrate source results in hyperlipoproteinemia in excess of that of dietary glucose or fructose...
  23. THE CELLULAR ORGANIZATION OF CHOLESTEROL BIOSYNTHESIS
    Yvonne Lange; Fiscal Year: 1990
    ..The proposed approach will involve subcellular fractionation of cell homogenates by equilibrium sucrose density centrifugation, rate zonal sedimentation in sucrose gradients and two phase aqueous partition...
  24. Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo
    CHIFU HUANG; Fiscal Year: 2006
    ..sweeteners that are commercially available, designed to provide zero- or low-calorie artificial alternatives to sucrose/high fructose corn syrup, there remain concerns regarding potential health concerns in the general population or ..
  25. Effects of Clopazine and haloperidol on responding
    Danielle Gulick; Fiscal Year: 2010
    ..the CPP paradigm;(3) to determine whether the hamster shows a higher motivation to consume alcohol and isocaloric sucrose, compared to saccharin, water, and food, in an OSA paradigm;and (4) to determine whether HAL, but not CLOZ, will ..
  26. Temporal Coding in the Gustatory System of the Brain
    Patricia M Di Lorenzo; Fiscal Year: 2011
    ..of electrical stimulation can mimic the perceptual properties and behavioral reactivity of either quinine or sucrose and b) construct a temporal sequence of electrical pulses which incorporates the critical features of the ..
  27. Food Reward and Stress
    YVONNE MICHELLE ULRICH-LAI; Fiscal Year: 2011
    ..in which rats with free access to food and water are given twice-daily access to a small amount of palatable sucrose solution or water as a control...
  28. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2010
    ..or cell signaling inhibitors to modulate performance in a behavioral task that models diet recidivism, relapse to sucrose-seeking;2) the effect of high fat diet experience on sucrose self-administration in pre- and post-pubertal rats;..
  29. Mechanisms of Virulence Gene Regulation in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2007
    ..S. mutans synthesizes glucans from sucrose by three glucosyltransferases (Gtf), and adheres firmly to tooth surfaces with their cooperation...
  30. GOLGI APPARATUS & GERL IN NORMAL AND PATHOLOGIC LIVER
    Phyllis Novikoff; Fiscal Year: 1980
    ..to the OA diet; and (3) that a fatty liver can be induced quickly by feeding a semisynthetic diet rich in sucrose to the homozygous mutant ("fatty") Zucker rat...
  31. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    ARNOLD BLEIWEIS; Fiscal Year: 2000
    ..by a number of virulence factors including an adhesin (P1), which promotes colonization in the absence of dietary sucrose and the ability of this species to withstand the effects of low pH caused by the homofermentation of sugars...
  32. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    ARNOLD BLEIWEIS; Fiscal Year: 2001
    ..by a number of virulence factors including an adhesin (P1), which promotes colonization in the absence of dietary sucrose and the ability of this species to withstand the effects of low pH caused by the homofermentation of sugars...
  33. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    ARNOLD BLEIWEIS; Fiscal Year: 1999
    ..by a number of virulence factors including an adhesin (P1), which promotes colonization in the absence of dietary sucrose and the ability of this species to withstand the effects of low pH caused by the homofermentation of sugars...
  34. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2002
    ..by a number of virulence factors including an adhesin (P1), which promotes colonization in the absence of dietary sucrose and the ability of this species to withstand the effects of low pH caused by the homofermentation of sugars...
  35. Role of the SrmB Helicase in Ribosome Assembly investigated by Mass Spectrometry
    Carla F Cervantes; Fiscal Year: 2012
    ..coli strain, fractionally separated by sucrose gradient ultracentrifugation...
  36. SENSORY CODING IN TASTE
    David Smith; Fiscal Year: 1999
    ..sodium channel projects into NaCl-best afferent fibers in the chorda tympani nerve and into both NaCl- and sucrose-best neurons in the nucleus of the solitary tract (NST) of the hamster...
  37. SENSORY CODING IN TASTE
    David Smith; Fiscal Year: 2000
    ..sodium channel projects into NaCl-best afferent fibers in the chorda tympani nerve and into both NaCl- and sucrose-best neurons in the nucleus of the solitary tract (NST) of the hamster...
  38. ADHERENCE FACTORS OF ORAL STREPTOCOCCI
    RONALD DOYLE; Fiscal Year: 1990
    ..These bacteria are acidogenic and aciduric. The mutans streptococci can also utilize sucrose as a source of fermentable carbohydrate and as a substrate for D-glucan synthesis...
  39. ADHERENCE FACTORS OF ORAL STREPTOCOCCI
    RONALD DOYLE; Fiscal Year: 1993
    ..These bacteria are acidogenic and aciduric. The mutans streptococci can also utilize sucrose as a source of fermentable carbohydrate and as a substrate for D-glucan synthesis...
  40. Role of Lipoprotein Receptors in Diet-induced Obesity and Diabetes
    David Hui; Fiscal Year: 2007
    ..results showed that VLDLR'/~ mice were resistant to obesity and diabetes after feeding a high fat-high sucrose diabetogenic diet...
  41. Role of Lipoprotein Receptors in Diet-induced Obesity and Diabetes
    David Hui; Fiscal Year: 2009
    ..results showed that VLDLR'/~ mice were resistant to obesity and diabetes after feeding a high fat-high sucrose diabetogenic diet...
  42. STUDIES ON THE GENETICS OF ORAL MICROFLORA
    FRANCIS MACRINA; Fiscal Year: 1991
    ..is the principal etiologic agent of this disease and the unique ability of this organism to metabolize dietary sucrose is known to be crucial to virulence...
  43. ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 1992
    ..system (PTS) transports and phosphorylates a variety of sugars such as glucose, fructose, mannitol, lactose and sucrose. Glucose and other sugar substrates of the PTS (PTS sugars) repress synthesis of carbohydrate catabolic enzymes, ..
  44. ATP DEPENDENT PROTEIN KINASES IN GRAM POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 2000
    ..system (PTS) transports and phosphorylates a variety of sugars such as glucose, fructose, mannitol, lactose and sucrose. Glucose and other sugar substrates of the PTS (PTS sugars) repress synthesis of carbohydrate catabolic enzymes, ..
  45. ATP DEPENDENT PROTEIN KINASES IN GRAM POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 1999
    ..system (PTS) transports and phosphorylates a variety of sugars such as glucose, fructose, mannitol, lactose and sucrose. Glucose and other sugar substrates of the PTS (PTS sugars) repress synthesis of carbohydrate catabolic enzymes, ..
  46. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2001
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  47. Development of Novel Therapies or Methamphetamine Abuse
    Linda Dwoskin; Fiscal Year: 2009
    ..a complete blockade of methamphetamine self-administration (SA) in rats, without any alteration in responding for sucrose, i.e., it specifically decreases methamphetamine SA...
  48. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2002
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  49. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2003
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  50. ANTIBODY MEDIATED GLOMERULAR INJURY
    David Salant; Fiscal Year: 2004
    ..High molecular weight complexes of nephrin will be isolated by co-immunoprecipitation or sucrose density ultracentrifugation and analyzed for interacting proteins using tandem mass spectroscopy...
  51. ANTIBODY MEDIATED GLOMERULAR INJURY
    David Salant; Fiscal Year: 2003
    ..High molecular weight complexes of nephrin will be isolated by co-immunoprecipitation or sucrose density ultracentrifugation and analyzed for interacting proteins using tandem mass spectroscopy...
  52. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2003
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  53. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2002
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  54. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2002
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  55. ANTIBODY MEDIATED GLOMERULAR INJURY
    David Salant; Fiscal Year: 2002
    ..High molecular weight complexes of nephrin will be isolated by co-immunoprecipitation or sucrose density ultracentrifugation and analyzed for interacting proteins using tandem mass spectroscopy...
  56. ANTIBODY MEDIATED GLOMERULAR INJURY
    David Salant; Fiscal Year: 2001
    ..High molecular weight complexes of nephrin will be isolated by co-immunoprecipitation or sucrose density ultracentrifugation and analyzed for interacting proteins using tandem mass spectroscopy...
  57. REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTS
    Gloria Coruzzi; Fiscal Year: 2000
    ..For example, transcriptional induction of GS by light, can be mimicked by sucrose in the absence of light...
  58. SUCROSE AND/OR FAT INGESTION EFFECT ON OPIOIDS
    Allen Levine; Fiscal Year: 2002
    ..Opioid antagonists are particularly effective at decreasing intake of preferred foods including high sucrose and/or high fat foods. For example, we found that extremely low doses of the opioid antagonist naloxone (0...