carrageenan

Summary

Summary: A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.

Top Publications

  1. pmc Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity
    Stuart G Turville
    Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America
    PLoS ONE 3:e3162. 2008
  2. pmc Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression
    Inmaculada Posadas
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano 49, Naples 80131, Italy
    Br J Pharmacol 142:331-8. 2004
  3. doi Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice
    Takahiro Kataoka
    Graduate School of Health Sciences, Okayama University, 5 1 Shikata cho 2 chome, Kita ku, Okayama Shi, Okayama 700 8558, Japan
    Inflammation 35:713-22. 2012
  4. ncbi Excitatory amino acid receptor antagonists and electroacupuncture synergetically inhibit carrageenan-induced behavioral hyperalgesia and spinal fos expression in rats
    Yu Qiu Zhang
    Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
    Pain 99:525-35. 2002
  5. ncbi Carrageenan-induced paw edema in the rat and mouse
    Christopher J Morris
    University of Bath, UK
    Methods Mol Biol 225:115-21. 2003
  6. ncbi Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
    Joel A Black
    Department of Neurology and Paralyzes Veterans of America, Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven CT 06510, USA
    Pain 108:237-47. 2004
  7. ncbi Interference in dengue virus adsorption and uncoating by carrageenans
    Laura B Talarico
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina
    Virology 363:473-85. 2007
  8. ncbi Acceptability of Carraguard vaginal gel use among Thai couples
    Sara J Whitehead
    National Center for HIV, Viral Hepatitis, STDs, and Tuberculosis Prevention proposed, Centers for Disease Control and Prevention, Atlanta, USA
    AIDS 20:2141-8. 2006
  9. pmc Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
    Qinghao Xu
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:2113-24. 2011
  10. ncbi Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan
    M Ombrellino
    Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Shock 15:181-5. 2001

Research Grants

  1. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2006
  2. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2007
  3. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2006
  4. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2005
  5. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2004
  6. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1990
  7. RAS SIGNALING AND NEUTROPHIL ACTIVATION IN SLE
    Mark Philips; Fiscal Year: 1993
  8. EXPERIMENTAL MODEL FOR ULCERATIVE COLITIS
    Andrew Onderdonk; Fiscal Year: 1980
  9. The Regulation of Inflammatory Responses by CD73
    Linda Thompson; Fiscal Year: 2007
  10. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    THOMAS PAUL DAVIS; Fiscal Year: 2010

Detail Information

Publications306 found, 100 shown here

  1. pmc Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity
    Stuart G Turville
    Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America
    PLoS ONE 3:e3162. 2008
    ..This work also underscores the potential of Carraguard-based formulations for the delivery of anti-viral drugs to prevent vaginal HIV infection...
  2. pmc Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression
    Inmaculada Posadas
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano 49, Naples 80131, Italy
    Br J Pharmacol 142:331-8. 2004
    Injection of carrageenan 1% (50 microl) in the mouse paw causes a biphasic response: an early inflammatory response that lasts 6 h and a second late response that peaks at 72 h, declining at 96 h...
  3. doi Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice
    Takahiro Kataoka
    Graduate School of Health Sciences, Okayama University, 5 1 Shikata cho 2 chome, Kita ku, Okayama Shi, Okayama 700 8558, Japan
    Inflammation 35:713-22. 2012
    We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m(3) of radon for 24 h...
  4. ncbi Excitatory amino acid receptor antagonists and electroacupuncture synergetically inhibit carrageenan-induced behavioral hyperalgesia and spinal fos expression in rats
    Yu Qiu Zhang
    Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
    Pain 99:525-35. 2002
    ..AMPA/KA) receptor antagonist, (6,7-dinitroquinoxaline-2,3 (1H,4H); DNQX) administered intrathecally on carrageenan-induced thermal hyperalgesia and spinal c-Fos expression was investigated...
  5. ncbi Carrageenan-induced paw edema in the rat and mouse
    Christopher J Morris
    University of Bath, UK
    Methods Mol Biol 225:115-21. 2003
  6. ncbi Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
    Joel A Black
    Department of Neurology and Paralyzes Veterans of America, Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven CT 06510, USA
    Pain 108:237-47. 2004
    ..In addition, 4 days following injection of carrageenan into the hind paw, an established model of inflammatory pain, Na(v)1...
  7. ncbi Interference in dengue virus adsorption and uncoating by carrageenans
    Laura B Talarico
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina
    Virology 363:473-85. 2007
    ..001-1. The inhibitory action of the lambda-carrageenan, an heparan sulfate (HS)-imitative compound, was exerted by a dual interference with virus adsorption and ..
  8. ncbi Acceptability of Carraguard vaginal gel use among Thai couples
    Sara J Whitehead
    National Center for HIV, Viral Hepatitis, STDs, and Tuberculosis Prevention proposed, Centers for Disease Control and Prevention, Atlanta, USA
    AIDS 20:2141-8. 2006
    ..To evaluate the acceptability of candidate microbicide Carraguard among couples participating in a safety trial...
  9. pmc Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
    Qinghao Xu
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:2113-24. 2011
    ..with inhibitors to PI3K or Akt attenuated Formalin-induced second-phase flinching behavior, as well as carrageenan-induced thermal hyperalgesia and tactile allodynia...
  10. ncbi Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan
    M Ombrellino
    Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Shock 15:181-5. 2001
    ..of fetuin were studied in vivo in an LPS-independent model of acute inflammation caused by administration of carrageenan. Administration of fetuin (5-500 mg/kg intraperitoneally) dose-dependently attenuated the development of paw ..
  11. pmc Sinularin from indigenous soft coral attenuates nociceptive responses and spinal neuroinflammation in carrageenan-induced inflammatory rat model
    Shi Ying Huang
    Department of Marine Biotechnology and Resources, Asia Pacific Ocean Research Center, National Sun Yat Sen University, Kaohsiung 80424, Taiwan
    Mar Drugs 10:1899-919. 2012
    ..ago, the marine-derived compound sinularin was shown to have anti-edematous effects on paw edema induced by carrageenan or adjuvant...
  12. doi Low-frequency electroacupuncture suppresses carrageenan-induced paw inflammation in mice via sympathetic post-ganglionic neurons, while high-frequency EA suppression is mediated by the sympathoadrenal medullary axis
    Hyun Woo Kim
    Department of Veterinary Physiology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
    Brain Res Bull 75:698-705. 2008
    ..of low (1Hz, LF EA) versus high (120Hz, HF EA) frequency EA stimulation on SNS activation and ultimately on carrageenan-induced inflammation...
  13. doi CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria, Gazzi, 98100 Messina, Italy
    Eur J Pharmacol 668:305-16. 2011
    ..1mg/kgi.p.), an agonist of the adenosine (A(2A)) receptor, in a mouse model of carrageenan-induced pleurisy...
  14. ncbi Morphological and biochemical characterization of macrophages activated by carrageenan and lipopolysaccharide in vivo
    Valéria Pereira Nacife
    Laboratorio de Ultra estrutura Celular, Departamento de Ultra estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Av Brasil 4365, Manguinhos, 21045 900, Rio de Janeiro, RJ, Brazil
    Cell Struct Funct 29:27-34. 2004
    ..In this work our aim was to analyze the surface charge of cells activated by carrageenan (CAR) and lipopolysaccharide (LPS) through light and electron microscopy approaches as well as the release of ..
  15. pmc Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia
    Gwen McCaffrey
    Department of Medical Pharmacology, University of Arizona College of Medicine, Tucson, Arizona 85745, USA
    J Neurochem 106:2395-409. 2008
    ..In this study, we investigated the effect of lambda-carrageenan-induced peripheral inflammatory pain (i.e...
  16. ncbi Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the rat
    Letícia Bignotto
    Departamentos de Farmacologia, Universidade Estadual de Campinas, Sao Paulo, SP, Brazil
    Br J Nutr 102:126-33. 2009
    ..In order to study the effects of lycopene in local inflammation, a carrageenan-induced paw oedema model in rats was performed...
  17. pmc Iota-carrageenan is a potent inhibitor of influenza A virus infection
    Andreas Leibbrandt
    Marinomed Biotechnologie GmbH, Vienna, Austria
    PLoS ONE 5:e14320. 2010
    ..In vitro tests demonstrated that iota-carrageenan is a potent inhibitor of influenza A virus infection, most importantly also of pandemic H1N1/2009 in vitro...
  18. doi Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation
    Fernando Spiller
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Pharm Pharmacol 60:473-8. 2008
    ..baccatum juice in animal models of acute inflammation induced by carrageenan and immune inflammation induced by methylated bovine serum albumin...
  19. doi Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice
    Sofia Mariotto
    Biochemistry Division, Department of Neuroscience and Vision, University of Verona, Verona, Italy
    Pharmacol Res 57:110-24. 2008
    ..whether AuE administration attenuates inflammatory response of murine induced by intrapleural injection of carrageenan. For this purpose we studied: (1) STAT1/3 activation, (2) TNF-alpha, IL-1beta and IL-6 production in pleural ..
  20. ncbi The protective role of endogenous glutathione in carrageenan-induced pleurisy in the rat
    S Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Eur J Pharmacol 372:187-97. 1999
    ..the protective role of endogenous glutathione, a known free radical scavenger, in rats subjected to carrageenan-induced pleurisy...
  21. ncbi Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1
    Jocelyne Guay
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 279:24866-72. 2004
    ..levels and in expression of terminal prostanoid synthases in both the CNS and inflamed peripheral tissue during carrageenan-induced paw inflammation in the rat...
  22. ncbi Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain
    Iain T Strickland
    Division of Neuroscience, University of Edinburgh, Medical College, 1 George Sq, Edinburgh EH8 9JZ, UK
    Eur J Pain 12:564-72. 2008
    ..work has revealed acute administration of inflammatory mediators, such as Freund's complete adjuvant (FCA) or carrageenan caused an upregulation in the levels of Na(V)1.7 and Na(V)1...
  23. ncbi Peripheral nitric oxide in carrageenan-induced inflammation
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, 060 8543, Sapporo, Japan
    Brain Res 912:171-5. 2001
    ..The present study was designed to examine the effects of NOS isoforms on NO release in carrageenan-induced inflammation at various time points...
  24. ncbi Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw
    M Gentilli
    , , , France
    Life Sci 68:1317-21. 2001
    ..inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat...
  25. doi Crucial role of neutrophils in the development of mechanical inflammatory hypernociception
    Thiago M Cunha
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Leukoc Biol 83:824-32. 2008
    ..In the present study, we addressed these mechanisms in the carrageenan-induced mechanical hypernociception, which was determined using a modification of the Randall-Sellito test in ..
  26. ncbi Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice
    Marta Menegazzi
    Biochemistry Division, Department of Neuroscience and Vision, University of Verona, Verona, Italy
    Pharmacol Res 58:22-31. 2008
    ..this study we evaluated the anti-inflammatory activities of glycyrrhizin in mice model of acute inflammation, carrageenan-induced pleurisy. We report here that glycyrrhizin (given at 10 mg/kg i.p...
  27. doi Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia
    Giuseppe D'Agostino
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Eur J Pharmacol 613:54-9. 2009
    ..Using the carrageenan-induced paw model of hyperalgesia in mice, we report here that intracerebroventricular administration of PEA (0...
  28. ncbi Protective effect of melatonin in carrageenan-induced acute local inflammation
    D Bilici
    Department of Pharmacology, Medical School, Ataturk University, 25240 Erzurum, Turkey
    Pharmacol Res 46:133-9. 2002
    ..to investigate the protective effect of the pineal hormone melatonin in a model of acute local inflammation (carrageenan-induced paw oedema)...
  29. ncbi An electronic pressure-meter nociception paw test for rats
    G G Vivancos
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 37:391-9. 2004
    ....
  30. pmc Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat
    N K Boughton Smith
    Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 110:896-902. 1993
    ..Furthermore, the results suggest that the anti-inflammatory actions of BW755C can be dissociated from its effects on arachidonic acid metabolism and are attributed to its anti-oxidant activity...
  31. pmc Compartmental relaxation and diffusion tensor imaging measurements in vivo in lambda-carrageenan-induced edema in rat skeletal muscle
    Reuben H Fan
    Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232 2310, USA
    NMR Biomed 21:566-73. 2008
    ....
  32. ncbi Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model
    P Pratheesh Kumar
    Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Immunopharmacol Immunotoxicol 31:94-102. 2009
    ..It was also found that Vernonia cinerea extract significantly inhibited carrageenan induced inflammation, compared with control models...
  33. doi Exposure to the common food additive carrageenan leads to glucose intolerance, insulin resistance and inhibition of insulin signalling in HepG2 cells and C57BL/6J mice
    S Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, 840 South Wood Street, CSN 440, M C 718, Chicago, IL 60612, USA
    Diabetologia 55:194-203. 2012
    The aim of this study was to determine the impact of the common food additive carrageenan (E407) on glucose tolerance, insulin sensitivity and insulin signalling in a mouse model and human hepatic cells, since carrageenan is known to ..
  34. doi Diclofenac attenuates the regional effect of lambda-carrageenan on blood-brain barrier function and cytoarchitecture
    Tracy A Brooks
    Departments of Pharmacology and Toxicology, University of Arizona Colleges of Pharmacy, Tucson, Arizona, USA
    J Pharmacol Exp Ther 325:665-73. 2008
    ..Edema and hyperalgesia were induced by lambda-carrageenan and attenuated by the additional administration of diclofenac...
  35. doi Electroacupuncture inhibits phosphorylation of spinal phosphatidylinositol 3-kinase/Akt in a carrageenan-induced inflammatory rat model
    Ha Neui Kim
    Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan 626 870, Republic of Korea
    Brain Res Bull 87:199-204. 2012
    ..the changes of pain-related spinal signaling pathway after electroacupuncture (EA) stimulation in a carrageenan-induced rat model...
  36. ncbi Preparation and application of poly(N,N-dimethylacrylamide-co-acrylamide) and poly(N-isopropylacrylamide-co-acrylamide)/kappa-Carrageenan hydrogels for immobilization of lipase
    H Tumturk
    Gazi University, Faculty of Art and Science, Department of Chemistry, Biotechnology Research Laboratory, 06500 Besevler, Ankara, Turkey
    Int J Biol Macromol 40:281-5. 2007
    ..that are poly(N,N-dimethylacrylamide-co-acrylamide) and poly(N-isopropylacrylamide-co-acrylamide)/kappa-Carrageenan was synthesized and applied for immobilization of lipase...
  37. doi Chondrogenic phenotype of different cells encapsulated in κ-carrageenan hydrogels for cartilage regeneration strategies
    Elena Popa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Taipas, Guimaraes, Portugal
    Biotechnol Appl Biochem 59:132-41. 2012
    ..Hydrogels based on κ-carrageenan (κC), a thermoreversible natural-origin polymer, have been recently proposed as new cell/growth factor ..
  38. pmc Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat
    E Ekundi-Valentim
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Br J Pharmacol 159:1463-74. 2010
    ..This study was undertaken to evaluate the ability of endogenous and exogenous H(2)S to modulate carrageenan-induced synovitis in the rat knee.
  39. doi Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats
    D De Filippis
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Pharmacol Res 61:321-8. 2010
    ..These findings suggest that chronic inflammation might develop also because of endocannabinoid and palmitoylethanolamide tissue concentration impairment, the correction of which might be exploited to develop new anti-inflammatory drugs...
  40. pmc Central nervous system mast cells in peripheral inflammatory nociception
    Dimitris N Xanthos
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
    Mol Pain 7:42. 2011
    ..Changes of lower spinal cord dura mast cells and their contribution to hyperalgesia are examined in animal models of peripheral neurogenic and non-neurogenic inflammation...
  41. ncbi Anti-inflammatory activity of Albizia lebbeck Benth., an ethnomedicinal plant, in acute and chronic animal models of inflammation
    N Prakash Babu
    Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai 600 034, Tamil Nadu, India
    J Ethnopharmacol 125:356-60. 2009
    ..The aim of the present study was to evaluate the scientific basis of anti-inflammatory activity of different organic solvent extracts of Albizia lebbeck...
  42. doi The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine, School of Medicine, University of Messina, Via C Valeria, Gazzi 98100 Messina, Italy
    Clin Nutr 30:533-40. 2011
    ..The aim of this study was to investigate the effects of oleuropein aglycone, a hydrolysis product of oleuropein, in a mouse model of carrageenan-induced pleurisy.
  43. doi Esenbeckia leiocarpa Engl. inhibits inflammation in a carrageenan-induced murine model of pleurisy
    Patricia Pozzatti
    Department of Clinical Analysis, Centre for Health Sciences, Federal University of Santa Catarina, Campus Universitario, Trindade, Florianopolis, SC, Brazil
    J Pharm Pharmacol 63:1091-102. 2011
    ..The aim of this study was to investigate the anti-inflammatory effects of the crude hydroalcoholic extract (CHE) isolated from Esenbeckia leiocarpa Engl., and fractions and subfractions derived from it...
  44. ncbi Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin
    S Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    J Pineal Res 27:9-14. 1999
    ..of melatonin on the production of the inflammatory mediator prostaglandins in a model of acute inflammation, carrageenan-induced pleurisy, where prostaglandins are known to play a crucial role. The results show that melatonin (12...
  45. ncbi Sequence determination of sulfated carrageenan-derived oligosaccharides by high-sensitivity negative-ion electrospray tandem mass spectrometry
    Guangli Yu
    Institute of Marine Drug and Food, Ocean University of China, Qingdao, Shandong 266003, China
    Anal Chem 78:8499-505. 2006
    ..dissociation is assessed for sequence determination of multiply sulfated oligosaccharide fragments of carrageenan obtained from partial depolymerization of the polysaccharides by either enzymatic digestion or mild acid ..
  46. doi Carraguard acceptability among men and women in a couples study in Thailand
    Sarah Martin
    Ibis Reproductive Health, Cambridge, Massachusetts 02138, USA
    J Womens Health (Larchmt) 19:1561-7. 2010
    ..The aim of this study is to evaluate the use and acceptability of Carraguard among men and women enrolled as couples in a microbicide trial...
  47. doi Anti-inflammatory activities of 6β-acetoxy-7α-hydroxyroyleanone from Taiwania cryptomerioides Hayata ex vivo and in vivo
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:11211-8. 2011
    ..7) ex vivo and carrageenan (Carr)-induced mouse paw edema model in vivo. When RAW 264...
  48. doi A randomized, placebo-controlled trial to assess the safety and acceptability of use of carraguard vaginal gel by heterosexual couples in Thailand
    Peter H Kilmarx
    National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Sex Transm Dis 35:226-32. 2008
    To determine the safety and acceptability of use of Carraguard, a carrageenan-derived candidate microbicide gel, during sexual intercourse in women and men.
  49. pmc The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat
    S Cuzzocrea
    Institute of Pharmacology, University of Messina, Italy
    Mol Med 7:478-87. 2001
    ..Here we investigate the effects of endogenous estrogens in rats subjected to carrageenan-induced pleurisy.
  50. doi In vitro inhibitory effect of carrageenan oligosaccharide on influenza A H1N1 virus
    Wei Wang
    Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, PR China
    Antiviral Res 92:237-46. 2011
    b>Carrageenan polysaccharide has been reported to be able to inhibit the infection and replication of many different kinds of viruses...
  51. ncbi Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema
    Zekai Halici
    Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240, Erzurum, Turkey
    Eur J Pharmacol 566:215-21. 2007
    ..as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema...
  52. ncbi Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B
    Won Hwan Park
    National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, Korea
    Immunopharmacol Immunotoxicol 26:103-12. 2004
    ..Effects of the GBH extracts on carrageenan-induced edema inflammation using female (C57BL/6XC3H) F1 (B6C3F1) mice and tumorigenesis were examined...
  53. doi Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice
    Tien Ning Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 59:9112-9. 2011
    ..acid-induced writhing response and the formalin test, and its anti-inflammatory effects using the model of λ-carrageenan (Carr)-induced paw edema...
  54. doi Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo
    Chi Luan Wen
    Taiwan Seed Improvement and propagation Station, Council of Agriculture, Propagation Technology Section, Taichung, Taiwan
    J Ethnopharmacol 137:575-84. 2011
    ..This study aimed to explore the folk use of Antrodia cinnamomea on pharmacological grounds to characterize the scientific basis of anti-inflammatory activity...
  55. ncbi Effects of dopaminergic agents on carrageenan hyperalgesia after intrathecal administration to rats
    X Gao
    Department of Neurobiology, State Key Laboratory of Medical Neurobiology, Medical Center of Fudan University, 200032, Shanghai, China
    Eur J Pharmacol 418:73-7. 2001
    The present study explored the role of dopaminergic transmission in spinal cord in a model of carrageenan-induced inflammatory pain by examining the effects of selective agonists and antagonists of dopamine receptors...
  56. doi Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications
    Vítor Espírito Santo
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Taipas, Guimaraes, Portugal
    Biomacromolecules 10:1392-401. 2009
    ..In this study, kappa-carrageenan, a naturally occurring polymer, was used to develop hydrogel beads with the ability to incorporate GFs with the ..
  57. doi Hyper-production and characterization of the ι-carrageenase useful for ι-carrageenan oligosaccharide production from a deep-sea bacterium, Microbulbifer thermotolerans JAMB-A94T, and insight into the unusual catalytic mechanism
    Yuji Hatada
    Marine Biodiversity Research Program, Institute of Biogeosciences, Japan Agency for Marine Earth Science and Technology JAMSTEC, 2 15 Natsushima, Yokosuka, 237 0061, Japan
    Mar Biotechnol (NY) 13:411-22. 2011
    ..It cleaved β-1,4 linkages in ι-carrageenan to produce a high ratio of ι-carrageenan tetramer, more than 75% of the total product, and did not cleave the ..
  58. doi Additive anti-hyperalgesia of electroacupuncture and intrathecal antisense oligodeoxynucleotide to interleukin-1 receptor type I on carrageenan-induced inflammatory pain in rats
    Ming Juan Song
    Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Brain Res Bull 78:335-41. 2009
    ..to evaluate the effects of EA and antisense oligodeoxynucleotide (ODN) to IL-1 receptor type I (IL-1RI) on carrageenan-induced thermal hyperalgesia and the expression of IL-1beta as well as IL-1RI...
  59. ncbi Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw
    L C Loram
    Brain Function Research Unit, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa
    J Pain 8:127-36. 2007
    ..Tissue and plasma samples were taken 3, 6, or 24 h after carrageenan or saline injection into one of the 2 sites...
  60. doi Prevention of human enterovirus 71 infection by kappa carrageenan
    Ya Huang Chiu
    Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan
    Antiviral Res 95:128-34. 2012
    ..In this study, we report kappa carrageenan also has a strong and effective anti-EV 71 activity able to reduce plaque formation, prevent viral replication ..
  61. ncbi Elevated serum leptin concentrations induced by experimental acute inflammation
    O Gualillo
    Department of Medicine, University of Santiago de Compostela, School of Medicine, Spain
    Life Sci 67:2433-41. 2000
    ..was to evaluate serum leptin levels in response to two well-established models of acute inflammation in rats: carrageenan rat paw induced oedema and carrageenan induced pleurisy...
  62. ncbi Pain behavior and spinal cell activation due to carrageenan-induced inflammation in two inbred rat strains with differential hypothalamic-pituitary-adrenal axis reactivity
    Pierre Eric Juif
    Laboratory of Neurophysiology and Psychobiology, University of Luxembourg, 162A, avenue de la Faiencerie, L 1511 Luxembourg, Luxembourg
    Physiol Behav 105:901-8. 2012
    ..and thermal pain thresholds were measured prior to and during one week after intraplantar injection of carrageenan. The activation of nociceptive neurons (FosB), astroglia (GFAP) and microglia (OX-42) in the spinal cord of ..
  63. doi Ionically cross-linked carrageenan-alginate hydrogel beads
    Z Mohamadnia
    Iran Polymer and Petrochemical Institute IPPI, P O Box 14965 115, Tehran, Iran
    J Biomater Sci Polym Ed 19:47-59. 2008
    Hydrogel beads based on the carbohydrate biopolymers kappa-carrageenan and sodium alginate were newly prepared...
  64. pmc The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques
    R Singer
    Center for Biomedical Research, Population Council, New York, New York, USA
    J Virol 85:5504-12. 2011
    ..demonstrated that a formulation of the nonnucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 in carrageenan reduced vaginal infection of macaques with simian immunodeficiency virus SIVmac239 with HIV-1(HxB2) reverse ..
  65. doi Acceptability of a carrageenan-based candidate vaginal microbicide and matching placebo: findings from a phase II safety trial among women in Chiang Rai, Thailand
    Heidi E Jones
    Population Council, New York, New York, USA
    J Womens Health (Larchmt) 18:1003-10. 2009
    To evaluate extended acceptability of vaginal use of a carrageenan-based candidate microbicide and placebo in northern Thai women.
  66. ncbi Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema
    R Albertini
    Research Group of Fluorescence, IP and D UNIVAP R, Shishima Hifumi, 2911, 12244 000 Sao Jose dos Campos, SP, Brazil
    J Photochem Photobiol B 74:101-7. 2004
    ..Male Wistar rats were used. The rat paw oedema was induced by sub-plantar injection of carrageenan, the paw volume was measured before and 1, 2, 3 and 4 h after the injection using a hydroplethysmometer...
  67. doi Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats
    Daniele De Filippis
    Universita Federico II, Napoles, Italy
    J Cell Mol Med 13:1086-95. 2009
    ..g. iNOS, chymase and metalloproteinase MMP-9), and mediators (e.g. nitric oxide and TNF-alpha). The results indicate that adelmidrol, given locally, may represent a potential therapeutic tool in controlling chronic inflammation...
  68. ncbi Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice
    Giuseppe D'Agostino
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharmacol Exp Ther 322:1137-43. 2007
    ..Using carrageenan-induced paw edema in mice, we show that i.c.v...
  69. ncbi Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial
    Stephanie Skoler-Karpoff
    Population Council, New York, NY, USA
    Lancet 372:1977-87. 2008
    Female-initiated HIV-prevention options, such as microbicides, are urgently needed. We assessed Carraguard, a carrageenan-based compound developed by the Population Council, for its efficacy and long-term safety in prevention of HIV ..
  70. ncbi Suppression of allergic reaction by lambda-carrageenan: toll-like receptor 4/MyD88-dependent and -independent modulation of immunity
    R F Tsuji
    Noda Institute for Scientific Research, Noda City, Japan
    Clin Exp Allergy 33:249-58. 2003
    ..Because PRRs recognize heterogeneous ligands, daily food intake can potentially regulate immune allergic reaction...
  71. pmc Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis
    Masahiko Ikeuchi
    Physical Therapy and Rehabilitation Science Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa, USA
    J Pain 10:336-42. 2009
    ..We examined ASIC3 expression in DRG neurons innervating the knee joint with and without carrageenan-induced arthritis by means of retrograde labeling and immunohistochemistry...
  72. ncbi Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema
    A Gepdiremen
    Department of Pharmacology, Medical Faculty, Ondokuz Mayis University, TR 55050 Kurupelit, Samsun Turkey
    Phytomedicine 12:440-4. 2005
    ..colchica was investigated in carrageenan-induced acute paw edema in rats. Saponins and indomethacin were given orally in concentrations of 0...
  73. pmc Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats
    L C Stanfa
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT
    Br J Pharmacol 129:351-9. 2000
    ..In contrast, intrathecal administration of 500 microg of suramin to animals 3 h after the induction of carrageenan inflammation produced a significant inhibition of the C-fibre evoked response of the neurones...
  74. ncbi Desulfation of sulfated galactans with chlorotrimethylsilane. Characterization of beta-carrageenan by 1H NMR spectroscopy
    Adriana A Kolender
    Departamento de Quimica Organica, CIHIDECAR CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2 Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Carbohydr Res 339:1619-29. 2004
    ..It proved to be appropriate for desulfation of polysaccharides of both agar and carrageenan families...
  75. ncbi Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat
    Víctor Fernández-Dueñas
    Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine, University of Barcelona, Feixa Llarga s n, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Pain 12:157-63. 2008
    ..Acute inflammation was induced by the subplantar injection of carrageenan into the right hind paw, and the effects of the drugs were evaluated from 0 to 5h...
  76. ncbi Putative antinociceptive action of nitric oxide in the caudal part of the spinal trigeminal nucleus during chronic carrageenan-induced arthritis in the rat temporomandibular joint
    Silvia A Tesser-Viscaíno
    Institute of Biology, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Brain Res 1302:85-96. 2009
    In order to investigate a putative role for nitric oxide (NO) in the central nociceptive processing following carrageenan-induced arthritis in the rat temporomandibular joint (TMJ), we analyzed the immunoreactivity, gene expression and ..
  77. doi Effects of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan induced inflammation
    I Ince
    Center for Drug R and D and Pharmacokinetic Applications, Ege University, 35100 Bornova Izmir, Turkey
    Phytomedicine 16:1101-4. 2009
    ..to explore the anti-inflammatory activities of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan-induced inflammation. Firstly, the compositions of both samples were determined using HPLC...
  78. pmc Adsorption of human papillomavirus 16 to live human sperm
    Julio Pérez-Andino
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS ONE 4:e5847. 2009
    ..observed that the interaction of virus with sperm can be reduced by two HPV infection inhibitors, heparin and carrageenan. Our findings suggest that 1) sperm cells may serve as motile carriers that promote virus dispersal and mucosal ..
  79. pmc Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Nutr Biochem 21:906-13. 2010
    The common food additive carrageenan (CGN) predictably induces intestinal inflammation in animal models...
  80. doi Drug release from MCC- and carrageenan-based pellets: experiment and theory
    H Kranz
    Pharmaceutical Technology, Bayer Schering Pharma AG, Berlin D 13342, Germany
    Eur J Pharm Biopharm 73:302-9. 2009
    ..from MCC pellets by addition of a disintegrant (croscarmellose Na) or pore former (PEG 6000), (ii) to evaluate carrageenan as potential alternative pelletisation aid for manufacturing high-dose immediate release pellets, and (iii) to ..
  81. ncbi Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide
    Bárbara B Garrido-Suárez
    Laboratorio de Farmacología Clínica del Centro Nacional Coordinador de Ensayos Clínicos, Calle 200 e 19 y 21, Atabey, Playa, Apdo Postal 11600, La Habana, Cuba
    Brain Res Bull 79:339-44. 2009
    ..effect of EA (10 Hz, 3 mA) and its combination with L-NAME as nitric oxide synthase (NOS) inhibitor in carrageenan-induced hyperalgesia in rats...
  82. ncbi Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat
    S Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    FASEB J 15:1187-200. 2001
    ..of n-acetylcysteine (NAC), a free radical scavenger, was evaluated in an experimental model of lung injury (carrageenan-induced pleurisy)...
  83. doi Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat
    Ernest M Hoffman
    Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA
    Neurosci Lett 472:157-60. 2010
    ..In this study, we measured the effects of glutaminase inhibition on carrageenan-induced spinal Fos expression...
  84. ncbi Hypericum perforatum attenuates the development of carrageenan-induced lung injury in mice
    Marta Menegazzi
    Biochemistry Division, Department of Neuroscience and Vision, University of Verona, Italy
    Free Radic Biol Med 40:740-53. 2006
    ..perforatum in an animal model of acute inflammation, carrageenan-induced pleurisy. We report here that H...
  85. ncbi Physicochemical characterization of papain entrapped in ionotropically cross-linked kappa-carrageenan gel beads for stability improvement using Doehlert shell design
    Mayur G Sankalia
    Pharmacy Department, Centre of Relevance and Excellence in Novel Drug Delivery Systems, G H Patel building, Donor s Plaza, The M S University of Baroda, Vadodara 390 002, India
    J Pharm Sci 95:1994-2013. 2006
    This work examines the influence of various process parameters on papain entrapped in cross-linked kappa-carrageenan beads for improvement of its stability...
  86. pmc Increased carrageenan-induced acute lung inflammation in old rats
    Emanuela Corsini
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Immunology 115:253-61. 2005
    ..The purpose of this study was to investigate the effect of age on the onset of carrageenan-induced lung inflammation...
  87. ncbi The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats
    D J Schrier
    Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, MI 48105
    J Immunol 145:1874-9. 1990
    ..antiinflammatory agents, several compounds were evaluated for effects on the exudative and cellular phases of carrageenan-induced pleural inflammation in rats...
  88. pmc Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice
    S Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Br J Pharmacol 149:687-702. 2006
    ..Here, we have investigated the effects of TDZD-8, a potent and selective GSK-3beta inhibitor, in a mouse model of carrageenan-induced pleurisy.
  89. ncbi Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-induced pleurisy
    S Cuzzocrea
    Institute of Pharmacology, University of Messina, Italy
    Free Radic Biol Med 26:25-33. 1999
    ..a novel superoxide dismutase mimetic that possesses peroxynitrite scavenging effect, in rats subjected to carrageenan-induced pleurisy...
  90. ncbi Antiinflammatory effect of topically applied propolis extract in carrageenan-induced rat hind paw edema
    Yukiko Naito
    Laboratory of Pharmacology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Phytother Res 21:452-6. 2007
    The antiinflammatory effect of an ointment containing propolis extract (3%-7%) was examined using carrageenan-induced hind paw edema in rats...
  91. pmc Degradation of lambda-carrageenan by Pseudoalteromonas carrageenovora lambda-carrageenase: a new family of glycoside hydrolases unrelated to kappa- and iota-carrageenases
    Marion Guibet
    Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie PARIS6, Unité Mixte de Recherche 7139 Marine Plants and Biomolecules, Station Biologique, F 29682 Roscoff Cedex, Bretagne, France
    Biochem J 404:105-14. 2007
    ..They are classified according to the number and the position of sulfate ester groups. lambda-Carrageenan is the most sulfated carrageenan and carries at least three sulfates per disaccharide unit...
  92. ncbi Spontaneous nociceptive behaviour in female mice with Freund's complete adjuvant- and carrageenan-induced monoarthritis
    Umut Heilborn
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res 1143:143-9. 2007
    ..Intraarticular injection of 2% carrageenan performed for comparison, caused pain-related behaviour for less than 24 h...
  93. ncbi Intracerebroventricular injection of phospholipases A2 inhibitors modulates allodynia after facial carrageenan injection in mice
    Jin Fei Yeo
    Department of Oral and Maxillofacial Surgery, National University of Singapore, Lower Kent Ridge Road, Singapore, Singapore 119260
    Pain 112:148-55. 2004
    ..to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice...
  94. doi Effects of a bupivacaine nerve block on the axonal transport of Tumor Necrosis Factor-alpha (TNF-alpha) in a rat model of carrageenan-induced inflammation
    Stéphane Deruddre
    Univ Paris Sud, Laboratoire d Anesthésie, UMR 788, Faculte de Medecine, F 94276 Le Kremlin Bicetre, France
    Brain Behav Immun 24:652-9. 2010
    ..We used an in vivo preparation with injection of carrageenan and fluorescent TNF-alpha in the territory of the saphenous nerve of rats to study this transport...
  95. ncbi Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats
    Philippe Richebe
    Laboratoire Homéostasie Allostasie Pathologie Rehabilitation, Universite Bordeaux 2, Universite Bordeaux 1, CNRS UMR 5227, 146 rue Leo Saignat, 33076, Bordeaux Cedex, France
    Can J Anaesth 56:126-35. 2009
    ..The aim of this study was to evaluate sevoflurane effects on fentanyl-induced hyperalgesia in opioid-naive rats and in rats with inflammatory pain...
  96. ncbi A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis
    C J LaBuda
    Department of Psychology, University of Texas at Arlington, 76019, USA
    Life Sci 69:443-54. 2001
    ..was to investigate whether chronic aspartame exposure possesses analgesic and anti-inflammatory actions in the carrageenan-induced monoarthritis model similar to those properties of aspirin...
  97. doi cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia
    Huaqing Liu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6100, USA
    J Med Chem 51:7094-8. 2008
    ..Most interesting was the high potency and efficacy of this compound in blocking pain responses, where it showed an ED(50) of 42 mumol/kg (ip) in a rat post-carrageenan thermal hyperalgesia model of inflammatory pain.
  98. doi Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch
    Silvana Virginia Gagliotti Vigil
    Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitario, Trindade, 88040 970, Florianopolis, SC, Brazil
    Transpl Immunol 19:25-9. 2008
    ..Tacrolimus (Tac) is a macrolide immunosuppressant drug isolated from Streptomyces tsukubaensis, widely used in organ transplantation...
  99. ncbi Microstructure of aggregated and nonaggregated kappa-carrageenan helices visualized by atomic force microscopy
    S Ikeda
    Department of Food and Nutrition, Osaka City University, Sumiyoshi, Osaka 558-8585, Japan. ikedalife.osaka-cu.ac.jp
    Biomacromolecules 2:1331-7. 2001
    Gelation of kappa-carrageenan is believed to involve two steps: helix formation on cooling and a further specific cation (salt) induced side-by-side aggregation of helices...
  100. ncbi Effect of low molecular lambda-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu
    Gefei Zhou
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, PR China
    Pharmacol Res 53:129-34. 2006
    Lambda-carrageenan is a kind of sulfated galactan isolated from some red algae and reported to have more biological activities than other types, such as K-type [Güven KC, özsoy Y, Ulutin ON...
  101. ncbi Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities
    Patrick Vlieghe
    Laboratoire de Chimie Biomoleculaire, Faculte des Sciences de Luminy, 163 Avenue de Luminy, Case 901, 13288 Marseille Cedex 9, France
    J Med Chem 45:1275-83. 2002
    This paper describes the first covalent synthesis of kappa-carrageenan-3'-azido-3'-deoxythymidine (AZT) conjugates. A succinate diester spacer was used to covalently couple AZT onto kappa-carrageenan, resulting in a tripartite prodrug...

Research Grants73

  1. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2006
    ..calcitonin gene-related peptide (CGRP) and corticotropin releasing factor (CRF), in the amygdala in our kaolin/carrageenan arthritis pain model...
  2. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2007
    ..calcitonin gene-related peptide (CGRP) and corticotropin releasing factor (CRF), in the amygdala in our kaolin/carrageenan arthritis pain model...
  3. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2006
    ..calcitonin gene-related peptide (CGRP) and corticotropin releasing factor (CRF), in the amygdala in our kaolin/carrageenan arthritis pain model...
  4. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2005
    ..calcitonin gene-related peptide (CGRP) and corticotropin releasing factor (CRF), in the amygdala in our kaolin/carrageenan arthritis pain model...
  5. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2004
    ..calcitonin gene-related peptide (CGRP) and corticotropin releasing factor (CRF), in the amygdala in our kaolin/carrageenan arthritis pain model...
  6. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1990
    ..will be examined in the KJ using an acute inflammatory response evoked by intrasynovial injection of kaolin and carrageenan. 3) "The antidromic evoked release of peripheral SP-LI is subject to modulation by several classes of local ..
  7. RAS SIGNALING AND NEUTROPHIL ACTIVATION IN SLE
    Mark Philips; Fiscal Year: 1993
    ..Elucidation of the mechanisms of ras-mediated neutrophil activation may reveal novel strategies for antiinflammatory therapy in SLE...
  8. EXPERIMENTAL MODEL FOR ULCERATIVE COLITIS
    Andrew Onderdonk; Fiscal Year: 1980
    Conventional guinea pigs fed a solution of 5% w/v degraded carrageenan developed ulcerations of the cecum and large intestine within 30 days...
  9. The Regulation of Inflammatory Responses by CD73
    Linda Thompson; Fiscal Year: 2007
    ..We will focus initially on two model systems where adenosine receptors are known to be important: the carrageenan-treated air pouch (Aim I) and LPS-induced septic shock (Aim II)...
  10. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    THOMAS PAUL DAVIS; Fiscal Year: 2010
    ..Studies from our laboratory show that peripheral inflammatory pain induced by ?-carrageenan, formalin or complete Freund's adjuvant, increases paracellular BBB permeability, alters multi-drug ..
  11. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    Thomas Davis; Fiscal Year: 2009
    ..Studies from our laboratory show that peripheral inflammatory pain induced by ?-carrageenan, formalin or complete Freund's adjuvant, increases paracellular BBB permeability, alters multi-drug ..
  12. The Regulation of Inflammatory Responses by CD73
    Linda Thompson; Fiscal Year: 2003
    ..We will focus initially on two model systems where adenosine receptors are known to be important: the carrageenan-treated air pouch (Aim I) and LPS-induced septic shock (Aim II)...
  13. The Regulation of Inflammatory Responses by CD73
    Linda Thompson; Fiscal Year: 2005
    ..We will focus initially on two model systems where adenosine receptors are known to be important: the carrageenan-treated air pouch (Aim I) and LPS-induced septic shock (Aim II)...
  14. The Regulation of Inflammatory Responses by CD73
    Linda Thompson; Fiscal Year: 2004
    ..We will focus initially on two model systems where adenosine receptors are known to be important: the carrageenan-treated air pouch (Aim I) and LPS-induced septic shock (Aim II)...
  15. The Regulation of Inflammatory Responses by CD73
    Linda Thompson; Fiscal Year: 2006
    ..We will focus initially on two model systems where adenosine receptors are known to be important: the carrageenan-treated air pouch (Aim I) and LPS-induced septic shock (Aim II)...
  16. Carraguard/Levonogestrel Combination for Dual Protection
    REGINE SITRUK WARE; Fiscal Year: 2011
    ..a product, combining the microbicide Carraguard, (the main ingredient of which is the sulfated polysaccharide carrageenan) with the synthetic progestin levonorgestrel (LNg)...
  17. A topical treatment for genital papillomavirus infections
    Richard Schlegel; Fiscal Year: 2006
    ..The first compound is carrageenan, which was recently shown by Dr...
  18. A topical treatment for genital papillomavirus infections
    Richard Schlegel; Fiscal Year: 2007
    ..The first compound is carrageenan, which was recently shown by Dr...
  19. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2003
    ..to determine antihyperalgesic properties of intarplantar and intrathecal cannabinoids using the capsaicin and carrageenan models of inflammation (Aim 1); to determine whether cannabinoids reduce sensitization of cutaneous nociceptors ..
  20. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2001
    ..to determine antihyperalgesic properties of intarplantar and intrathecal cannabinoids using the capsaicin and carrageenan models of inflammation (Aim 1); to determine whether cannabinoids reduce sensitization of cutaneous nociceptors ..
  21. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2000
    ..to determine antihyperalgesic properties of intarplantar and intrathecal cannabinoids using the capsaicin and carrageenan models of inflammation (Aim 1); to determine whether cannabinoids reduce sensitization of cutaneous nociceptors ..
  22. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2002
    ..to determine antihyperalgesic properties of intarplantar and intrathecal cannabinoids using the capsaicin and carrageenan models of inflammation (Aim 1); to determine whether cannabinoids reduce sensitization of cutaneous nociceptors ..
  23. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2004
    ..to determine antihyperalgesic properties of intarplantar and intrathecal cannabinoids using the capsaicin and carrageenan models of inflammation (Aim 1); to determine whether cannabinoids reduce sensitization of cutaneous nociceptors ..
  24. MECHANISMS OF INJURY IN IMMUNE COMPLEX NEPHRITIS
    Lawrence Hunsicker; Fiscal Year: 1980
    ..We propose to deplete monocytes by intraperitoneal injection of carrageenan, a monocyte toxin, and observe the effects on glomerular hypercellularity, glomerular proliferative response ..
  25. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2009
    ..We will continue to use our well-established pain model, the kaolin/carrageenan-induced knee joint arthritis. The following specific hypotheses will be tested: 1...
  26. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2009
    ..We will continue to use our well-established pain model, the kaolin/carrageenan-induced knee joint arthritis. The following specific hypotheses will be tested: 1...
  27. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2010
    ..We will continue to use our well-established pain model, the kaolin/carrageenan-induced knee joint arthritis. The following specific hypotheses will be tested: 1...
  28. TRANSGENIC PROBES OF GLUCOCORTICOID INVOLVEMENT IN AGING
    James Nelson; Fiscal Year: 2000
    ..2) The anti-inflammatory action of DR. The time-course of carrageenan-induced foot pad edema and its resolution will be used as the index of inflammation in the aforementioned ..
  29. CARRAGUARD-LEVONORGESTREL COMBINATION -- DUAL PROTECTION
    Regine Sitruk Ware; Fiscal Year: 2002
    ..to develop such a product by combining the microbicide Carraguard, which is the sulfated polysaccharide, carrageenan, with the synthetic progestin, levonorgestrel (LNG)...
  30. TRANSGENIC PROBES OF GLUCOCORTICOID INVOLVEMENT IN AGING
    James Nelson; Fiscal Year: 1999
    ..2) The anti-inflammatory action of DR. The time-course of carrageenan-induced foot pad edema and its resolution will be used as the index of inflammation in the aforementioned ..
  31. SUPRASPINAL MODULATION OF HYPERALGESIA
    Mark Urban; Fiscal Year: 1999
    ..The model of primary hyperalgesia (noxious stimulation at the site of injury) will involve carrageenan injection into the planter surface of the hind foot, and models of secondary hyperalgesia (noxious stimulation ..
  32. SUPRASPINAL MODULATION OF HYPERALGESIA
    Mark Urban; Fiscal Year: 2000
    ..The model of primary hyperalgesia (noxious stimulation at the site of injury) will involve carrageenan injection into the planter surface of the hind foot, and models of secondary hyperalgesia (noxious stimulation ..
  33. Nociceptor Maturation and Response to Peripheral Injury
    CHARLES JEFFERY WOODBURY; Fiscal Year: 2011
    ..induced inflammation in facial skin of newborn mice;the long-term effects of neonatal adjuvant-induced and carrageenan-induced inflammation will be compared to analyze potential differences between persistent versus acute ..
  34. Nociceptor Maturation and Response to Peripheral Injury
    CHARLES JEFFERY WOODBURY; Fiscal Year: 2010
    ..induced inflammation in facial skin of newborn mice;the long-term effects of neonatal adjuvant-induced and carrageenan-induced inflammation will be compared to analyze potential differences between persistent versus acute ..
  35. Nociceptor Maturation and Response to Peripheral Injury
    CHARLES WOODBURY; Fiscal Year: 2009
    ..induced inflammation in facial skin of newborn mice;the long-term effects of neonatal adjuvant-induced and carrageenan-induced inflammation will be compared to analyze potential differences between persistent versus acute ..
  36. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2004
    ..rats on models of acute nociceptive processing (thermal escape), post tissue injury pain states (formalin and carrageenan hyperalgesia), and in post nerve injury pain states (Chung tactile allodynia Vincristine evoked tactile ..
  37. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2002
    ..rats on models of acute nociceptive processing (thermal escape), post tissue injury pain states (formalin and carrageenan hyperalgesia), and in post nerve injury pain states (Chung tactile allodynia Vincristine evoked tactile ..
  38. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2003
    ..rats on models of acute nociceptive processing (thermal escape), post tissue injury pain states (formalin and carrageenan hyperalgesia), and in post nerve injury pain states (Chung tactile allodynia Vincristine evoked tactile ..
  39. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2004
    ..rats on models of acute nociceptive processing (thermal escape), post tissue injury pain states (formalin and carrageenan hyperalgesia), and in post nerve injury pain states (Chung tactile allodynia Vincristine evoked tactile ..
  40. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..rats on models of acute nociceptive processing (thermal escape), post tissue injury pain states (formalin and carrageenan hyperalgesia), and in post nerve injury pain states (Chung tactile allodynia Vincristine evoked tactile ..
  41. KLF2 monocyte activation and vascular inflammation
    Mukesh Jain; Fiscal Year: 2007
    ..Finally, reconstitution of immunodeficient mice with KLF2 overexpressing monocytes significantly reduced carrageenan-induced acute paw inflammation and edema...
  42. KLF2 monocyte activation and vascular inflammation
    Mukesh Jain; Fiscal Year: 2009
    ..Finally, reconstitution of immunodeficient mice with KLF2 overexpressing monocytes significantly reduced carrageenan-induced acute paw inflammation and edema...
  43. KLF2 monocyte activation and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2010
    ..Finally, reconstitution of immunodeficient mice with KLF2 overexpressing monocytes significantly reduced carrageenan-induced acute paw inflammation and edema...
  44. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    Thomas Davis; Fiscal Year: 2006
    ..increase in the permeability of the rat blood-brain barrier during three models of peripheral pain (Formalin, A-carrageenan, Complete Freunds Adjuvant) to [S14C] Sucrose which will only cross the blood-brain barrier if the tight ..
  45. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    Thomas Davis; Fiscal Year: 2005
    ..increase in the permeability of the rat blood-brain barrier during three models of peripheral pain (Formalin, A-carrageenan, Complete Freunds Adjuvant) to [S14C] Sucrose which will only cross the blood-brain barrier if the tight ..
  46. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    Thomas Davis; Fiscal Year: 2002
    ..increase in the permeability of the rat blood-brain barrier during three models of peripheral pain (Formalin, A-carrageenan, Complete Freunds Adjuvant) to [S14C] Sucrose which will only cross the blood-brain barrier if the tight ..
  47. BLOCKING DENDRITIC HIV/SIV BY CARRAGEENAN MICROBICIDES
    Melissa Robbiani; Fiscal Year: 2001
    ..This proposal will focus on defining how carrageenan-derived compounds impact DC-virus interactions and their ability to drive virus spread between cells in vitro ..
  48. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    Thomas Davis; Fiscal Year: 2004
    ..increase in the permeability of the rat blood-brain barrier during three models of peripheral pain (Formalin, A-carrageenan, Complete Freunds Adjuvant) to [S14C] Sucrose which will only cross the blood-brain barrier if the tight ..
  49. BLOOD BRAIN BARRIER CHANGES INDUCED BY PAIN
    Thomas Davis; Fiscal Year: 2003
    ..increase in the permeability of the rat blood-brain barrier during three models of peripheral pain (Formalin, A-carrageenan, Complete Freunds Adjuvant) to [S14C] Sucrose which will only cross the blood-brain barrier if the tight ..
  50. CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR
    JOHN O DALY; Fiscal Year: 1990
    Enzymes immobilized on colloidal gold and coated with carrageenan offer an important new route to amperometric biosensor electrodes...
  51. PAIN, NOCICEPTION, AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 1999
    ..The effects of persistent pain on the activity of CeA neurons will be studied using the kaolin/carrageenan inflamed knee joint model in the rat...
  52. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2001
    ..The effects of persistent pain on the activity of CeA neurons will be studied using the kaolin/carrageenan inflamed knee joint model in the rat...
  53. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2000
    ..The effects of persistent pain on the activity of CeA neurons will be studied using the kaolin/carrageenan inflamed knee joint model in the rat...
  54. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2002
    ..The effects of persistent pain on the activity of CeA neurons will be studied using the kaolin/carrageenan inflamed knee joint model in the rat...
  55. Ontogenic changes in injury-induced gene expression
    Gordon Barr; Fiscal Year: 2005
    ..In the putative critical period, during the first two weeks of life, pups are injected with carrageenan. Older pups are tested because they are outside the critical period...
  56. NEW EXPERIMENTAL MODEL FOR DORMANCY IN BREAST CANCER
    JEANNE SZALAY; Fiscal Year: 1990
    ..studies we will examine the effects of irradiated and formalinized tumor cells, cyclosporin, cyclophosphamide, carrageenan and anti-asialo GM1 serum on the tumor dormant state...
  57. ROLE OF VENULAR ENDOTHELIUM IN DIABETES
    JOHN MORDES; Fiscal Year: 1990
    ..2 is to determine which factor or factors are responsible for the macrophage toxins silica and carrageenan completely block Monastral blue induced leakage in the BB rat...
  58. Ontogenic changes in injury-induced gene expression
    Gordon Barr; Fiscal Year: 2006
    ..In the putative critical period, during the first two weeks of life, pups are injected with carrageenan. Older pups are tested because they are outside the critical period...
  59. Ontogenic changes in injury-induced gene expression
    Gordon Barr; Fiscal Year: 2004
    ..In the putative critical period, during the first two weeks of life, pups are injected with carrageenan. Older pups are tested because they are outside the critical period...
  60. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2005
    ..functions; (2) if selective neural blockade by RTX prevents and reverses pain behavior and hyperalgesia in carrageenan-induced inflammation and incisional injury; and (3) if the inactivation phase of the local effect of RTX on ..
  61. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2006
    ..functions; (2) if selective neural blockade by RTX prevents and reverses pain behavior and hyperalgesia in carrageenan-induced inflammation and incisional injury; and (3) if the inactivation phase of the local effect of RTX on ..
  62. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2004
    ..functions; (2) if selective neural blockade by RTX prevents and reverses pain behavior and hyperalgesia in carrageenan-induced inflammation and incisional injury; and (3) if the inactivation phase of the local effect of RTX on ..
  63. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..functions; (2) if selective neural blockade by RTX prevents and reverses pain behavior and hyperalgesia in carrageenan-induced inflammation and incisional injury; and (3) if the inactivation phase of the local effect of RTX on ..
  64. EVALUATION OF CARRAGEENAN-BASED MICROBICIDES
    David Katz; Fiscal Year: 2001
    ..intravaginal optical sensing device, developed by the applicant?s laboratory, will be employed to quantitate carrageenan formulation coating thickness distributions in women...
  65. PHARMACOKINETICS/TOXICOLOGY OF CARRAGEENAN MICROBICIDES
    MICHAEL ANAZODO; Fiscal Year: 2001
    ..This proposal seeks to characterize the stability, toxicology and the pharmacokinetics (PK) of PDR 98-15 carrageenan, and it derivatives Zinc- and Lignosulfonic acid (LSA)-carrageenan with the ultimate goal of establishing their ..
  66. Feasibility Study of Three NCEs for Rheumatoid Arthritis
    Jiajiu Shaw; Fiscal Year: 2004
    ..and our proprietary compound (compound A) and performed in vivo inhibition studies for inflammation induced by carrageenan. Based on the anti-inflammation results, we have selected three most promising compounds (UTL-5b, UTL-5d, and ..
  67. ZCM: A novel broad-spectrum microbicide for STIs
    Melissa Robbiani; Fiscal Year: 2009
    ..ZCM comprises Zn bound to carrageenan and the non-nucleotide reverse transcriptase inhibitor MIV-150...
  68. STRUCTURE AND FUNCTION OF PEYER'S PATCH EPITHELIUM
    Robert Owen; Fiscal Year: 1980
    ..in initiating this M cell independent immune response will be studied in vivo by destroying macrophages with carrageenan. Attachment of sensitized and unsensitized macrophages to Giardia will be studied in vitro...
  69. ZCM: A novel broad-spectrum microbicide for STIs
    Melissa Robbiani; Fiscal Year: 2007
    ..ZCM comprises Zn bound to carrageenan and the non-nucleotide reverse transcriptase inhibitor MIV-150...