blood glucose

Summary

Summary: Glucose in blood.

Top Publications

  1. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
  2. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  3. pmc Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    Benjamin F Voight
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Nat Genet 42:579-89. 2010
  4. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josée Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
  5. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
  6. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
  7. pmc Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
    N Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:2215-22. 2010
  8. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
  9. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
  10. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008

Detail Information

Publications353 found, 100 shown here

  1. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
    ....
  2. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  3. pmc Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    Benjamin F Voight
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Nat Genet 42:579-89. 2010
    ..We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits...
  4. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josée Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  5. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
    ..It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes...
  6. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  7. pmc Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
    N Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:2215-22. 2010
    ..We aimed to quantify these associations for a wide range of circumstances...
  8. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
    ..NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance...
  9. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
    ..Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year...
  10. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  11. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  12. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy...
  13. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  14. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  15. ncbi The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)
    Rachel P Wildman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Room 1309, Bronx, NY 10461, USA
    Arch Intern Med 168:1617-24. 2008
    ....
  16. pmc FGF-21 as a novel metabolic regulator
    Alexei Kharitonenkov
    Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Invest 115:1627-35. 2005
    ..Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes...
  17. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  18. ncbi 10-year follow-up of intensive glucose control in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    N Engl J Med 359:1577-89. 2008
    ..We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes...
  19. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003
  20. pmc Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas, USA
    Diabetes Care 35:1232-8. 2012
    ..To evaluate the effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, in type 2 diabetes mellitus inadequately controlled with metformin monotherapy...
  21. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  22. pmc Prediabetes: a high-risk state for diabetes development
    Adam G Tabák
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 379:2279-90. 2012
    ..For prediabetic individuals, lifestyle modification is the cornerstone of diabetes prevention, with evidence of a 40-70% relative-risk reduction. Accumulating data also show potential benefits from pharmacotherapy...
  23. ncbi Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
    ..Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied...
  24. ncbi Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    R C Turner
    Radcliffe Infirmary, Oxford, England
    JAMA 281:2005-12. 1999
    ..8 mmol/L (140 mg/dL) or glycosylated hemoglobin A1c (HbA1c) below 7% is unknown...
  25. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
    ..Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation of oxidative stress...
  26. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  27. ncbi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  28. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000
    ..To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans...
  29. ncbi Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis
    Daniel Umpierre
    Exercise Pathophysiology Research Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    JAMA 305:1790-9. 2011
    ..Regular exercise improves glucose control in diabetes, but the association of different exercise training interventions on glucose control is unclear...
  30. ncbi Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
    Ranganath Muniyappa
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9 Memorial Drive, Bldg 9, Rm 1N 105 MSC 0920, Bethesda, MD 20892, USA
    Am J Physiol Endocrinol Metab 294:E15-26. 2008
    ..In this Frontiers article, we highlight merits, limitations, and appropriate use of current in vivo measures of insulin sensitivity/resistance...
  31. pmc Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    Robert A Scott
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 44:991-1005. 2012
    ..Functional analysis of these newly discovered loci will further improve our understanding of glycemic control...
  32. pmc Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans
    Mikkel Christensen
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, Copenhagen, Denmark
    Diabetes 60:3103-9. 2011
    ..To evaluate the glucose dependency of glucose-dependent insulinotropic polypeptide (GIP) effects on insulin and glucagon release in 10 healthy male subjects ([means ± SEM] aged 23 ± 1 years, BMI 23 ± 1 kg/m(2), and HbA(1c) 5.5 ± 0.1%)...
  33. pmc Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study
    M Peyrot
    Department of Sociology, Loyola University of Maryland, Baltimore, MD 21210 2699, USA
    Diabet Med 29:682-9. 2012
    ..To examine patient and physician beliefs regarding insulin therapy and the degree to which patients adhere to their insulin regimens...
  34. pmc Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    D Russell-Jones
    Department of Diabetes and Endocrinology, Royal Guildford Hospital, UK
    Diabetologia 52:2046-55. 2009
    ..The aim of the study was to compare the efficacy and safety of liraglutide in type 2 diabetes mellitus vs placebo and insulin glargine (A21Gly,B31Arg,B32Arg human insulin), all in combination with metformin and glimepiride...
  35. ncbi Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Science 313:1137-40. 2006
    ..Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes...
  36. ncbi Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    Daniela M L Tsukumo
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Diabetes 56:1986-98. 2007
    ..Thus, TLR4 appears to be an important mediator of obesity and insulin resistance and a potential target for the therapy of these highly prevalent medical conditions...
  37. ncbi Effect of treatment of gestational diabetes mellitus on pregnancy outcomes
    Caroline A Crowther
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    N Engl J Med 352:2477-86. 2005
    ..We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications...
  38. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
    ..Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics...
  39. ncbi Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  40. pmc Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    K Stenlof
    Clinical Trial Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Diabetes Obes Metab 15:372-82. 2013
    ..Canagliflozin is a sodium glucose co-transporter 2 inhibitor in development for type 2 diabetes mellitus (T2DM). The efficacy and safety of canagliflozin were evaluated in subjects with T2DM inadequately controlled with diet and exercise...
  41. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    ..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
  42. pmc Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:2464-71. 2012
    ..To compare ultra-long-acting insulin degludec with glargine for efficacy and safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral antidiabetic drugs (OADs)...
  43. pmc miR-375 maintains normal pancreatic alpha- and beta-cell mass
    Matthew N Poy
    Institute of Molecular Systems Biology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:5813-8. 2009
    ..These data provide evidence that miR-375 is essential for normal glucose homeostasis, alpha- and beta-cell turnover, and adaptive beta-cell expansion in response to increasing insulin demand in insulin resistance...
  44. pmc Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    E L Lim
    Magnetic Resonance Centre, Institute of Cellular Medicine, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Diabetologia 54:2506-14. 2011
    ..Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake...
  45. ncbi Type 2 diabetes across generations: from pathophysiology to prevention and management
    Christopher J Nolan
    Department of Endocrinology, Canberra Hospital and Australian National University Medical School, Canberra, ACT, Australia
    Lancet 378:169-81. 2011
    ..Reversal of overnutrition, healing of the β cells, and lessening of adipose tissue defects should be treatment priorities...
  46. pmc Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
    Rémy Boussageon
    Department of General Medicine, Universite Claude Bernard Lyon 1, Lyon, France
    BMJ 343:d4169. 2011
    ..To determine all cause mortality and deaths from cardiovascular events related to intensive glucose lowering treatment in people with type 2 diabetes...
  47. ncbi DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    Thomas Blevins
    Texas Diabetes and Endocrinology, 6500 North Mopac Expressway, Building 3, Suite 200, Austin, Texas 78731, USA
    J Clin Endocrinol Metab 96:1301-10. 2011
    ..We wanted to understand the effects of once-weekly vs. twice-daily glucagon-like peptide-1 receptor agonism for treatment of patients with type 2 diabetes...
  48. ncbi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
    ..We analyzed data from a large study of intensive glucose lowering to explore the relationship between severe hypoglycemia and adverse clinical outcomes...
  49. ncbi Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    H Cho
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 292:1728-31. 2001
    ..We show that mice deficient in Akt2 are impaired in the ability of insulin to lower blood glucose because of defects in the action of the hormone on liver and skeletal muscle...
  50. ncbi Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control
    Susan L Norris
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 25:1159-71. 2002
    ..To evaluate the efficacy of self-management education on GHb in adults with type 2 diabetes...
  51. ncbi Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    D Devineni
    Janssen Research and Development, LLC, Raritan, NJ 08869, USA
    Diabetes Obes Metab 14:539-45. 2012
    ..Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that is being investigated for the treatment of type 2 diabetes mellitus (T2DM)...
  52. ncbi Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening
    K Srinivasan
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, Phase X, S A S Nagar, Mohali 160 062, Punjab, India
    Pharmacol Res 52:313-20. 2005
    ....
  53. ncbi Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
    N Unwin
    Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
    Diabet Med 19:708-23. 2002
    ..4. Life style interventions are highly effective in delaying or preventing the onset of diabetes in people with IGT and may reduce CVD and total mortality, but the latter requires formal testing...
  54. ncbi Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2906-12. 2006
    ..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
  55. ncbi Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 292:1440-6. 2004
    ..The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is poorly understood...
  56. ncbi Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1349-54. 2008
    ..To explore the possibility that oscillating glucose may outweigh A1C levels in determining the risk for cardiovascular diabetes complications...
  57. ncbi Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    M Elchebly
    Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6
    Science 283:1544-8. 1999
    ..Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of ..
  58. ncbi Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
    ..Conversely, even in obesity, a metabolically benign fat distribution phenotype may exist...
  59. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  60. ncbi Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study
    Craig J Currie
    Department of Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Lancet 375:481-9. 2010
    Results of intervention studies in patients with type 2 diabetes have led to concerns about the safety of aiming for normal blood glucose concentrations. We assessed survival as a function of HbA(1c) in people with type 2 diabetes.
  61. ncbi Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial
    Alan J Garber
    Baylor College of Medicine, Houston, TX, USA
    Lancet 379:1498-507. 2012
    ..Insulin degludec is a new, ultra-longacting basal insulin. We aimed to assess efficacy and safety of insulin degludec compared with insulin glargine in patients with type 2 diabetes mellitus...
  62. ncbi Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies
    Alan W Barclay
    Human Nutrition Unit, University of Sydney, Sydney, Australia
    Am J Clin Nutr 87:627-37. 2008
    ..Inconsistent findings from observational studies have prolonged the controversy over the effects of dietary glycemic index (GI) and glycemic load (GL) on the risk of certain chronic diseases...
  63. ncbi Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    Lazaros A Nikolaidis
    Cardiovascular Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 109:962-5. 2004
    ..Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties that stimulate glucose uptake without the requirements for concomitant glucose infusion...
  64. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
    ..We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol)...
  65. ncbi Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    Michaela Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, Netherlands
    Lancet 375:2234-43. 2010
    ..We aimed to test the hypothesis that improvement in haemoglobin A(1c) (HbA(1c)) achieved with once weekly exenatide was superior to that achieved with insulin glargine titrated to glucose targets...
  66. ncbi Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    G Xu
    Elliott P Joslin Research Laboratories, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 48:2270-6. 1999
    ..Thus, GLP-I and analogs thereof hold promise as a novel therapy to stimulate beta-cell growth and differentiation when administered to diabetic individuals with reduced beta-cell mass...
  67. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005
    ..S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP)...
  68. ncbi Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
  69. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabák
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  70. pmc Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
    Faramarz Ismail-Beigi
    Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
    Lancet 376:419-30. 2010
    ..We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes.
  71. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
    b>Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus...
  72. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  73. ncbi Objectively measured light-intensity physical activity is independently associated with 2-h plasma glucose
    Genevieve N Healy
    Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, Australia
    Diabetes Care 30:1384-9. 2007
    ..We examined the associations of objectively measured sedentary time, light-intensity physical activity, and moderate- to vigorous-intensity activity with fasting and 2-h postchallenge plasma glucose in Australian adults...
  74. ncbi Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials
    N G Boulé
    Clinical Epidemiology Unit, Ottawa Health Research Institute, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 286:1218-27. 2001
    ..However, clinical trials on the effects of exercise in patients with type 2 diabetes have had small sample sizes and conflicting results...
  75. ncbi Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study
    Bruce B Duncan
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 52:1799-805. 2003
    ..7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans...
  76. pmc Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
    ..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels...
  77. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
    ..Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction...
  78. ncbi International table of glycemic index and glycemic load values: 2002
    Kaye Foster-Powell
    Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
    Am J Clin Nutr 76:5-56. 2002
    ..The revised table also lists the glycemic load associated with the consumption of specified serving sizes of different foods...
  79. ncbi The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease
    David S Ludwig
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2414-23. 2002
    ..The purpose of this review is to examine the physiological effects of the glycemic index and the relevance of these effects in preventing and treating obesity, diabetes, and cardiovascular disease...
  80. pmc Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    Marleen Kars
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:1899-905. 2010
    ..The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women...
  81. ncbi Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    Anoja S Attele
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 51:1851-8. 2002
    ..01) compared with vehicle-treated ob/ob mice. The improvement in blood glucose levels in the extract-treated ob/ ob mice was associated with a significant reduction in serum insulin levels ..
  82. ncbi Exercise, glucose transport, and insulin sensitivity
    L J Goodyear
    Research Division, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Med 49:235-61. 1998
    ..However, there is now extensive epidemiological evidence demonstrating that long-term regular physical exercise can significantly reduce the risk of developing non-insulin-dependent diabetes mellitus...
  83. ncbi Intensive glucose control and macrovascular outcomes in type 2 diabetes
    F M Turnbull
    The George Institute for International Health, University of Sydney, Sydney, NSW 2050, Australia
    Diabetologia 52:2288-98. 2009
    ..The aim of these analyses was to generate more precise estimates of the effects of more-intensive, compared with less-intensive, glucose control on the risk of major cardiovascular events amongst patients with type 2 diabetes...
  84. ncbi Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 279:42351-4. 2004
  85. ncbi Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
    W S Yang
    Department of Internal Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan
    J Clin Endocrinol Metab 86:3815-9. 2001
    ..In addition, the increase in plasma adiponectin despite the reduction of the only tissue of its own synthesis suggests that the expression of adiponectin is under feedback inhibition in obesity...
  86. ncbi Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
    David B Sacks
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Thorn 530, 75 Francis St, Boston, MA 02115, USA
    Clin Chem 48:436-72. 2002
    ..Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially...
  87. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  88. ncbi Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity
    Utpal B Pajvani
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 278:9073-85. 2003
    ..Combined, these results shed new light on the regulation of this complex protein and suggest a new model for in vivo activation of the protein, implicating a serum reductase activity...
  89. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  90. pmc Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:17438-43. 2006
    ..The hMSCs lowered blood glucose levels in the diabetic mice on day 32 relative to untreated controls (18.34 mM +/- 1.12 SE vs. 27.78 mM +/- 2...
  91. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  92. pmc The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
    ..We sought to distinguish between these two mechanisms...
  93. ncbi A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    M Yoshioka
    Department of Hygiene, Akita University School of Medicine, Japan
    Diabetes 46:887-94. 1997
    ..At 7 weeks of age, the mean morning blood glucose levels (mmol/l) under ad libitum feeding conditions were significantly higher (P < 0...
  94. ncbi Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
    Nicola M McKeown
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:390-8. 2002
    The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control.
  95. ncbi Association of health literacy with diabetes outcomes
    Dean Schillinger
    University of California, San Francisco, Primary Care Research Center, Department of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    JAMA 288:475-82. 2002
    ..Little is known about the extent to which health literacy affects clinical health outcomes...
  96. ncbi Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    C Tourrel
    Laboratory of Physiopathology of Nutrition, Centre National de la Recherche Scientifique ESA 7059, Université Paris7 Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France
    Diabetes 50:1562-70. 2001
    ..Further studies are needed to understand the dissociation between beta-cell regeneration and the lack of improvement in beta-cell function...
  97. ncbi Disruption of IRS-2 causes type 2 diabetes in mice
    D J Withers
    Howard Hughes Medical Institute, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 391:900-4. 1998
    ..Our results indicate that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes...
  98. ncbi Glycemic control and complications in type 2 diabetes mellitus
    Mark Stolar
    Department of Clinical Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Med 123:S3-11. 2010
    ..Ongoing research into the mechanisms responsible for diabetic complications may provide new markers to help identify patients with type 2 diabetes who can benefit from earlier antidiabetes treatments...
  99. ncbi A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    Nabila Bouatia-Naji
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Nat Genet 41:89-94. 2009
    ..Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway...
  100. ncbi Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study
    Fereidoun Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, P O Box 4763, Tehran 19395, Iran
    Diabetes Res Clin Pract 61:29-37. 2003
    ..This report on the metabolic syndrome from Iran shows a high prevalence of this disorder. Efforts on promoting healthy diets, physical activity, and blood pressure control must be undertaken...
  101. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ....

Research Grants79

  1. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..Diabetes mellitus is a chronic disease that requires daily management to prevent large fluctuations in blood glucose levels and Diabetes disease management as well as biomedical sensor development is prime targets of the NIDDK ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..down regulation of the expression of PDKs is a critical component of the mechanism by which insulin controls blood glucose. Second, PDK knock out mice maintained on a high-fat, diabetogenic diet accumulate less fat in their livers, ..
  4. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..when challenged with glucose, insulin secretion from pancreatic 2-cells alone will not be adequate to dispose blood glucose. Therefore, CST is required to maintain euglycemia through suppression of hepatic insulin clearance...
  5. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..Lay Summary Insulin is critical for normal cardiovascular function as well as for maintaining normal blood glucose levels...
  6. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Insulin is critical for normal cardiovascular function as well as maintaining normal blood glucose levels...
  7. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..The mechanism for the control of blood glucose was linked to the suppression of hepatic nuclear content of forkhead box O1 (FoxO1), a major transcription ..
  8. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..To this end, blood glucose will be monitored and in vivo assessment of glucose tolerance and insulin sensitivity will be measured...
  9. A2b Adenosine Receptor Regulation of Metabolic Disease and Inflammation
    Anna Eisenstein; Fiscal Year: 2013
    ..morbidity and mortality in the United States T2D is defined by an inability of the body to respond to changing blood glucose levels due to reduced responsiveness of tissues to the glucose regulatory hormone, insulin, and/or an ..
  10. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..Hypothesis: That the presence of reduced renal mass or elevated blood glucose levels result in the initiation and acceleration of cystogenesis in mouse models of PKD...
  11. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..Several studies will involve varying the forearm blood glucose concentration for brief (30 min) to longer (2 hours) periods prior to APC and I/R injury...
  12. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..first generation of a low-cost, miniaturized, implantable sensor that can continuously and accurately monitor blood glucose levels over a period of one month...
  13. Hypo-Lipidemic Actions of Creosote Bush-Derived NDGA
    Salman Azhar; Fiscal Year: 2013
    ..LO) inhibitor, has profound effects on multiple components of the metabolic syndrome including lowering of blood glucose, free fatty acids (FFA) and triglyceride levels, attenuation of elevated blood pressure and improvement in ..
  14. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..Only 20 percent reported checking their blood glucose at least once a day, and 15 percent reported doing any type of exercise or physical activity...
  15. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..mass, intramyocellular lipid, bone density), cardiometabolic risk factors (Specific Aim #2: blood pressure, blood glucose, insulin, lipids, C-reactive protein, adiponectin, leptin, tumor necrosis factor-1, interleukin-6), functional ..
  16. Insulin Signaling and Metabolic Effects through CLK2 Kinase
    Pere Puigserver; Fiscal Year: 2013
    ..Notably, Clk2 controls expression of gluconeogenic genes, hepatic glucose output and blood glucose levels...
  17. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..in the United States of America;in these patients there is an inadequate number of beta cells to control blood glucose. Our proposed studies likely unravel a new pathway, the menin pathway, in controlling beta cell proliferation, ..
  18. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..Heel lance refers to the puncture of a newborn's heel for blood glucose using a specially designed lancet...
  19. Role of inflammation and cellular stress in the pathogenesis of type 2 diabetes
    Liangyou Rui; Fiscal Year: 2013
    ..Extensive studies demonstrate that inflammation induces insulin resistance, contributing to type 2 diabetes. Blood glucose levels are determined by a balance between insulin and counterregulatory hormones (e.g...
  20. Regulation of glucose metabolism by bone resorption and gamma-carboxylation
    Mathieu Ferron; Fiscal Year: 2012
    ..is to acquire a better understanding of the biological processes regulating the secretion of insulin and the control of blood glucose. This could potentially lead to new therapeutic approach for the treatment of diabetes and obesity.
  21. Novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes
    LIDIA NIEROBISZ; Fiscal Year: 2011
    ..The proof of principle compound reduces fasting blood glucose, decreases plasma free fatty acids and decreases lipid accumulation in the liver...
  22. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Complications from high blood glucose levels include cardiovascular complications, which are associated with increased morbidity and mortality...
  23. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..This paradoxically causes some GR-dependent agonist effects, thus weight gain and high blood glucose in BMPR2 mutant humans and mice, but causes inability to signal through others, leaving BMPR2 mutation ..
  24. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..elevated catecholamines), blood flow to skeletal muscle (atrial natriuretic factor, Neuropeptide Y) and blood glucose (pancreastatin)...
  25. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..ACE inhibitor and ARB treatment, this "aldosterone breakthrough" could reduce the beneficial effect on blood glucose. Drugs which inhibit aldosterone synthesis are in development and will provide a specific approach to block ..
  26. Novel Small Molecule Therapeutics to Treat Obesity
    SUSAN MEDGHALCHI; Fiscal Year: 2010
    ..fatty acid oxidation in DIO mice as measure by indirect calorimetry, (e) eliminate steatosis, normalize blood glucose, and reduce serum triglyceride levels in DIO mice, (f) increase expression of anorexigenic hypothalamic ..
  27. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..of islets with Adv-hHGF-hIL-1Ra prior to transplantation under the kidney capsules of NOD-SCID mice reduced blood glucose and increased the level of serum insulin and c-peptide levels upon glucose challenge...
  28. Cellular Mechanisms for Increased Gluconeogenesis in Type 2 Diabetes
    Varman T Samuel; Fiscal Year: 2013
    ..We will relate the expression and activity of these enzymes to the fasting blood glucose concentration, and also pre-prandial glucose, mean blood glucose concentrations (using continuous glucose ..
  29. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..design in which the primary aim will be evaluated by a within-subject comparison of HbA1C, a marker of blood glucose control and demonstrated predictor of diabetes complications and mortality, between baseline and 2 follow-up ..
  30. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ..syndrome risk factors (blood pressure, waist circumference, HDL cholesterol, triglycerides, and fasting blood glucose);(5) inflammatory markers (e.g...
  31. Development of New Therapeutics for Pancreatic Cancer Management
    RICHARD JOSEPH PIETRAS; Fiscal Year: 2013
    ..The primary systemic effect of metformin is to lower blood glucose, but it also reduces hyperinsulinemia associated with insulin resistance...
  32. Ligand Interaction of Glucagon Receptor by Structural and Functional Analyses
    FAI YIU SIU; Fiscal Year: 2012
    ..g. blood glucose regulation and bone homeostasis)...
  33. Prenatal stress biology, infant body composition and obesity risk
    Sonja Entringer; Fiscal Year: 2013
    ..labeled water (DLW) method;and metabolic function (insulin sensitivity) will be quantified from measures of blood glucose and insulin...
  34. A simple dietary message to improve dietary quality for metabolic syndrome
    Yunsheng Ma; Fiscal Year: 2012
    ..Assessments, including diet, anthropometrics, blood pressure, fasting blood glucose, glycosylated hemoglobin (HbA1c), blood lipids, insulin, inflammatory markers, medication use, depression, ..
  35. MAP Kinase Phosphatase 3 (MKP-3) and Obesity-related Gluconeogenesis
    Haiyan Xu; Fiscal Year: 2013
    ..In the insulin resistant diabetic state, blood glucose levels are elevated due to increased glucose production from the liver (mainly through de novo glucose ..
  36. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..In other words, hepatic aPKC inhibition has insulin-like effects on these hepatic enzymes that regulate blood glucose levels...
  37. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    ..called TORC2, that increases glucose production in the liver;insulin protects against abnormal elevations in blood glucose during feeding by turning off the TORC2 switch...
  38. A Mindfulness-Based Approach to the Treatment of Obesity and Diabetes
    Carla K Miller; Fiscal Year: 2010
    ..in improving weight and glycemic control in adults with diabetes, since stress can contribute to high blood glucose and poor eating habits...
  39. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2013
    ..called TORC2, that increases glucose production in the liver;insulin protects against abnormal elevations in blood glucose during feeding by turning off the TORC2 switch...
  40. Improving Outcomes for Women with GDM and Their Infants
    Alison M Stuebe; Fiscal Year: 2013
    ..Primary maternal outcomes will include fasting blood glucose and weight (BMI)...
  41. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian G Harbrecht; Fiscal Year: 2012
    ..Glucagon and insulin primarily regulate blood glucose, which has become an important facet of the care of critically ill patients, but we have found that they also ..
  42. Development of novel therapies for aging-induced skeletal muscle atrophy.
    SCOTT MATTHEW EBERT; Fiscal Year: 2013
    ..The study will also assess the effects of both compounds on fat mass, blood glucose and lipid levels, and liver and kidney function...
  43. Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I Trial
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2012
    ..blood will be analyzed for evidence of increases in parameters indicative of ketosis (serum ketones and blood glucose) as well as parameters of oxidative stress (lipid peroxidation, DNA oxidation, and protein oxidation)...
  44. ACCORD
    Faramarz Ismail Beigi; Fiscal Year: 2010
    ..type 2 diabetes at especially high risk for heart attack and stroke, the medical strategy to intensively lower blood glucose (sugar) below current recommendations increased the risk of death compared with a less-intensive standard ..
  45. ACCORD
    Richard Grimm; Fiscal Year: 2010
    ..type 2 diabetes at especially high risk for heart attack and stroke, the medical strategy to intensively lower blood glucose (sugar) below current recommendations increased the risk of death compared with a less-intensive standard ..
  46. Role of Perilipin in Hepatic Steatosis and Metabolism
    Thomas A Bowman; Fiscal Year: 2013
    ..experiments will expand our understanding of the mechanisms that regulate fat storage within the liver and blood glucose levels...
  47. Metabolic Syndrome, Fatty Acid Synthesis and Prostate Cancer
    Massimo Loda; Fiscal Year: 2012
    ..We are specifically focusing on a metabolic enzyme which is central to the control of obesity and blood glucose control in humans...
  48. Serum amyloid P and chronic noncommunicable diseases
    Weibin Shi; Fiscal Year: 2010
    ..that Apcs, which encodes SAP, is a promising candidate gene for a mouse chromosome 1 locus affecting fasting blood glucose levels and body weight...
  49. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..eye examination, including measurement of visual acuity, visual field, intraocular pressure, hemoglobin A1c, blood glucose, and serum C-reactive protein;additional tests will include optical coherence tomography of the anterior ..
  50. HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCC
    Vinay M Nadkarni; Fiscal Year: 2013
    ..Tight glycemic control (TGC) to normalize blood glucose concentrations with intravenous insulin significantly reduced mortality and morbidity in selected critically ..
  51. CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic Failure
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2012
    ..It is characterized by impairment of both the sensing of symptoms of falling blood glucose and the neuroendocrine counterregulatory response (CRR), a hormonal and neural response that includes ..
  52. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..The first is a 1968 study of human diabetics, which found that OAA treatment lowered blood glucose levels...
  53. Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial
    Anil Sapru; Fiscal Year: 2013
    ..Since the parent trial will not collect any blood samples other than for confirmation of blood glucose, we will approach parents or surrogates of children enrolled in the HALF PINT trial and obtain informed ..
  54. The role of phosphorylation in regulating the antidiabetic effects of O3FAR-1
    Nader H Moniri; Fiscal Year: 2013
    ..GLP-1), which stimulates pancreatic b-cells leading to insulin secretion and subsequently, decreases in blood glucose. In addition to this effect, it has recently been demonstrated that agonism of O3FAR1 leads to profound anti- ..
  55. Identification of Central Targets of Ghrelin
    Jeffrey M Zigman; Fiscal Year: 2010
    ..Ghrelin also affects blood glucose levels, the release of insulin and possibly the sensitivity to insulin...
  56. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    Larry W Swanson; Fiscal Year: 2012
    ..on localization either obesity or anorexia, profound effects on cardiovascular and endocrine (for example, blood glucose) measures, anxiety and mood, aggressive behavior, sexual behavior and physiology (for example, the menstrual ..
  57. Development of A Novel Anti-Hyperglycemic Agent
    Zhaoping Li; Fiscal Year: 2012
    ..The primary outcome of this study is improvement of hemoglubin A1c;secondary outcomes are fasting blood glucose, 2 hours postprandial glucose and glucose tolerance test...
  58. Functional Studies of the Incretin GIP Receptor in Adipocytes
    Timothy E McGraw; Fiscal Year: 2013
    ..To date, the best-described role GIP is to promote the amount of insulin secreted for a given rise in blood glucose. GIP itself does not stimulate insulin release. The functions of GIP are not limited to [unreadable]-cells...
  59. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2004
    Inadequate control of blood glucose contributes to the complications of diabetes (renal, retinal, neural)...
  60. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
    ..The specific aims include: (a) examine the effects of 2-chloropropionate on blood glucose, lactate, pyruvate, and alanine of the fasted rat; (b) to determine the effects of 2-chloropropionate on blood ..
  61. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 2001
    ..retinopathy is a disease of the retinal microvessels that is apparently a consequence of protracted high blood glucose levels...
  62. Liver Glycogen in Control of Plasma Glucose
    Katarina Borer; Fiscal Year: 2009
    ..We have recently found that a 20% lowering of blood glucose and altered pancreatic hormone response depend on exercise being performed in fasted/postabsorptive state, as ..
  63. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2004
    ..will examine the complex relationships between race, diabetes self-management (including self-monitoring of blood glucose and diabetes drug therapy), glycemic control, and diabetes complications in a managed care setting over a nine-..
  64. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..Our overall hypothesis is that antagonism of the GLP-1 receptor by exendin-(9-39) will increase fasting blood glucose levels, prevent protein-induced hypoglycemia and decrease glucose requirement to maintain euglycemia in ..
  65. DIETARY TREATMENT OF DIABETES MELITUS--META ANALYSIS
    Zung Tran; Fiscal Year: 1991
    ..modifications can affect the metabolic control and the lipid profile in NIDDM patients favorably by regulating blood glucose, by reducing total cholesterol, triglycerides, and low density lipoprotein-cholesterol and by elevating high ..
  66. Endothelial Function Predictors in Adolescent Diabetes
    ROBERT PAUL HOFFMAN; Fiscal Year: 2010
    ..function in adolescents with type 1 diabetes and 2) to determine the relationship of glycemic control and blood glucose variability as determined from continuous glucose monitoring to endothelial function in healthy type 1 ..
  67. Contracting and monitoring relationships between adolescents with type I diabetes
    Aaron Carroll; Fiscal Year: 2009
    ..patients, notably adolescents, have poor self-management practices that result in suboptimal control of their blood glucose levels...
  68. GLYCEMIC INDEX/GLYCEMIC LOAD AND BLOOD LIPIDS IN THE WHI
    James Shikany; Fiscal Year: 2004
    ..Recent evidence suggest that diets abundant in high-starch carbohydrates may have an adverse effect on blood glucose and insulin concentrations, resulting in alterations of blood lipids that may increase the risk of developing ..
  69. Novel Puerarin Analogs with Anti-Diabetic Activity
    NICHOLAS CAIRNS; Fiscal Year: 2007
    ..and/or promoting glucose disposal in the tissues may be beneficial for diabetic patients to control the blood glucose level in the postprandial state...
  70. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 2001
    ..of DN and recent clinical trials have shown a reduction in the progression of DN with careful control of blood glucose an intensive insulin therapy. However even excellent glycemic control fails to prevent or reverse DN...
  71. Primary Prevention of Weight Gain for Women Aged 25-45
    Walter Willett; Fiscal Year: 2004
    ..Many studies have demonstrated changes in blood glucose levels due to the intake of specific carbohydrate foods, as measured by glycemic index (GI)...
  72. Statistical Functional Data Analysis Models of Glucose and Insulin Kinetics
    Inna Chervoneva; Fiscal Year: 2010
    ..and hypoglycemia in patients now manually controlling the insulin delivery rate depending on the current blood glucose level and expected consumption of carbohydrates...
  73. Self-Cleaning Sensor Membranes to Improve Glucose Monitoring In Vivo
    MELISSA GRUNLAN; Fiscal Year: 2010
    ..There is an unmet need to develop a biosensor technology that is a fast and convenient way to monitor blood glucose in diabetics...
  74. REGULATION OF GENE EXPRESSION BY INSULIN-MIMETIC AGENTS
    Susan Stapleton; Fiscal Year: 1992
    ..investigator's abstract): Insulin has been shown to regulate many cellular processes including the control of blood glucose levels...