blood glucose

Summary

Summary: Glucose in blood.

Top Publications

  1. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
  2. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  3. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
  4. doi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
  5. pmc Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
    N Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:2215-22. 2010
  6. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
  7. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
  8. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003
  9. ncbi Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    Daniela M L Tsukumo
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Diabetes 56:1986-98. 2007
  10. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000

Detail Information

Publications326 found, 100 shown here

  1. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  2. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  3. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
    ..Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics...
  4. doi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
    ..It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes...
  5. pmc Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
    N Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:2215-22. 2010
    ..We aimed to quantify these associations for a wide range of circumstances...
  6. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  7. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
    ..NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance...
  8. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003
  9. ncbi Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    Daniela M L Tsukumo
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Diabetes 56:1986-98. 2007
    ..Thus, TLR4 appears to be an important mediator of obesity and insulin resistance and a potential target for the therapy of these highly prevalent medical conditions...
  10. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
    ..Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year...
  11. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  12. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  13. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  14. pmc FGF-21 as a novel metabolic regulator
    Alexei Kharitonenkov
    Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Invest 115:1627-35. 2005
    ..Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes...
  15. ncbi Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    R C Turner
    Radcliffe Infirmary, Oxford, England
    JAMA 281:2005-12. 1999
    ..8 mmol/L (140 mg/dL) or glycosylated hemoglobin A1c (HbA1c) below 7% is unknown...
  16. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  17. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy...
  18. pmc Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    D Russell-Jones
    Department of Diabetes and Endocrinology, Royal Guildford Hospital, UK
    Diabetologia 52:2046-55. 2009
    ..The aim of the study was to compare the efficacy and safety of liraglutide in type 2 diabetes mellitus vs placebo and insulin glargine (A21Gly,B31Arg,B32Arg human insulin), all in combination with metformin and glimepiride...
  19. ncbi Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Science 313:1137-40. 2006
    ..Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes...
  20. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  21. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  22. doi DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    Thomas Blevins
    Texas Diabetes and Endocrinology, 6500 North Mopac Expressway, Building 3, Suite 200, Austin, Texas 78731, USA
    J Clin Endocrinol Metab 96:1301-10. 2011
    ..We wanted to understand the effects of once-weekly vs. twice-daily glucagon-like peptide-1 receptor agonism for treatment of patients with type 2 diabetes...
  23. ncbi Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    H Cho
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 292:1728-31. 2001
    ..We show that mice deficient in Akt2 are impaired in the ability of insulin to lower blood glucose because of defects in the action of the hormone on liver and skeletal muscle...
  24. doi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
    ..We analyzed data from a large study of intensive glucose lowering to explore the relationship between severe hypoglycemia and adverse clinical outcomes...
  25. ncbi Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control
    Susan L Norris
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 25:1159-71. 2002
    ..To evaluate the efficacy of self-management education on GHb in adults with type 2 diabetes...
  26. ncbi Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    M Elchebly
    Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6
    Science 283:1544-8. 1999
    ..Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of ..
  27. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabak
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  28. ncbi Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies
    Alan W Barclay
    Human Nutrition Unit, University of Sydney, Sydney, Australia
    Am J Clin Nutr 87:627-37. 2008
    ..Inconsistent findings from observational studies have prolonged the controversy over the effects of dietary glycemic index (GI) and glycemic load (GL) on the risk of certain chronic diseases...
  29. ncbi Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  30. ncbi Effect of treatment of gestational diabetes mellitus on pregnancy outcomes
    Caroline A Crowther
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    N Engl J Med 352:2477-86. 2005
    ..We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications...
  31. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
    ..We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol)...
  32. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005
    ..S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP)...
  33. ncbi Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    G Xu
    Elliott P Joslin Research Laboratories, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 48:2270-6. 1999
    ..Thus, GLP-I and analogs thereof hold promise as a novel therapy to stimulate beta-cell growth and differentiation when administered to diabetic individuals with reduced beta-cell mass...
  34. doi Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    Michaela Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, Netherlands
    Lancet 375:2234-43. 2010
    ..We aimed to test the hypothesis that improvement in haemoglobin A(1c) (HbA(1c)) achieved with once weekly exenatide was superior to that achieved with insulin glargine titrated to glucose targets...
  35. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  36. ncbi Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
  37. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  38. ncbi Objectively measured light-intensity physical activity is independently associated with 2-h plasma glucose
    Genevieve N Healy
    Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, Australia
    Diabetes Care 30:1384-9. 2007
    ..We examined the associations of objectively measured sedentary time, light-intensity physical activity, and moderate- to vigorous-intensity activity with fasting and 2-h postchallenge plasma glucose in Australian adults...
  39. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
    b>Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus...
  40. ncbi Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study
    Bruce B Duncan
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 52:1799-805. 2003
    ..7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans...
  41. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
    ..Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction...
  42. pmc Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
    ..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels...
  43. ncbi International table of glycemic index and glycemic load values: 2002
    Kaye Foster-Powell
    Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
    Am J Clin Nutr 76:5-56. 2002
    ..The revised table also lists the glycemic load associated with the consumption of specified serving sizes of different foods...
  44. ncbi Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials
    N G Boulé
    Clinical Epidemiology Unit, Ottawa Health Research Institute, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 286:1218-27. 2001
    ..However, clinical trials on the effects of exercise in patients with type 2 diabetes have had small sample sizes and conflicting results...
  45. ncbi The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease
    David S Ludwig
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2414-23. 2002
    ..The purpose of this review is to examine the physiological effects of the glycemic index and the relevance of these effects in preventing and treating obesity, diabetes, and cardiovascular disease...
  46. doi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    ..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
  47. pmc Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    Marleen Kars
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:1899-905. 2010
    ..The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women...
  48. ncbi Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    Anoja S Attele
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 51:1851-8. 2002
    ..01) compared with vehicle-treated ob/ob mice. The improvement in blood glucose levels in the extract-treated ob/ ob mice was associated with a significant reduction in serum insulin levels ..
  49. ncbi Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 279:42351-4. 2004
  50. ncbi Intensive glucose control and macrovascular outcomes in type 2 diabetes
    F M Turnbull
    The George Institute for International Health, University of Sydney, Sydney, NSW 2050, Australia
    Diabetologia 52:2288-98. 2009
    ..The aim of these analyses was to generate more precise estimates of the effects of more-intensive, compared with less-intensive, glucose control on the risk of major cardiovascular events amongst patients with type 2 diabetes...
  51. ncbi Exercise, glucose transport, and insulin sensitivity
    L J Goodyear
    Research Division, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Med 49:235-61. 1998
    ..However, there is now extensive epidemiological evidence demonstrating that long-term regular physical exercise can significantly reduce the risk of developing non-insulin-dependent diabetes mellitus...
  52. ncbi Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
    W S Yang
    Department of Internal Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan
    J Clin Endocrinol Metab 86:3815-9. 2001
    ..In addition, the increase in plasma adiponectin despite the reduction of the only tissue of its own synthesis suggests that the expression of adiponectin is under feedback inhibition in obesity...
  53. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  54. ncbi Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
    David B Sacks
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Thorn 530, 75 Francis St, Boston, MA 02115, USA
    Clin Chem 48:436-72. 2002
    ..Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially...
  55. pmc Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
    Rémy Boussageon
    Department of General Medicine, Universite Claude Bernard Lyon 1, Lyon, France
    BMJ 343:d4169. 2011
    ..To determine all cause mortality and deaths from cardiovascular events related to intensive glucose lowering treatment in people with type 2 diabetes...
  56. ncbi Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity
    Utpal B Pajvani
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 278:9073-85. 2003
    ..Combined, these results shed new light on the regulation of this complex protein and suggest a new model for in vivo activation of the protein, implicating a serum reductase activity...
  57. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  58. pmc Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:17438-43. 2006
    ..The hMSCs lowered blood glucose levels in the diabetic mice on day 32 relative to untreated controls (18.34 mM +/- 1.12 SE vs. 27.78 mM +/- 2...
  59. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  60. pmc The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
    ..We sought to distinguish between these two mechanisms...
  61. ncbi A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    M Yoshioka
    Department of Hygiene, Akita University School of Medicine, Japan
    Diabetes 46:887-94. 1997
    ..At 7 weeks of age, the mean morning blood glucose levels (mmol/l) under ad libitum feeding conditions were significantly higher (P < 0...
  62. ncbi Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
    Nicola M McKeown
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:390-8. 2002
    The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control.
  63. ncbi Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    Lazaros A Nikolaidis
    Cardiovascular Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 109:962-5. 2004
    ..Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties that stimulate glucose uptake without the requirements for concomitant glucose infusion...
  64. ncbi Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    C Tourrel
    Laboratory of Physiopathology of Nutrition, Centre National de la Recherche Scientifique ESA 7059, Université Paris7 Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France
    Diabetes 50:1562-70. 2001
    ..Further studies are needed to understand the dissociation between beta-cell regeneration and the lack of improvement in beta-cell function...
  65. ncbi Disruption of IRS-2 causes type 2 diabetes in mice
    D J Withers
    Howard Hughes Medical Institute, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 391:900-4. 1998
    ..Our results indicate that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes...
  66. doi Glycemic control and complications in type 2 diabetes mellitus
    Mark Stolar
    Department of Clinical Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Med 123:S3-11. 2010
    ..Ongoing research into the mechanisms responsible for diabetic complications may provide new markers to help identify patients with type 2 diabetes who can benefit from earlier antidiabetes treatments...
  67. ncbi Association of health literacy with diabetes outcomes
    Dean Schillinger
    University of California, San Francisco, Primary Care Research Center, Department of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    JAMA 288:475-82. 2002
    ..Little is known about the extent to which health literacy affects clinical health outcomes...
  68. doi A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    Nabila Bouatia-Naji
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Nat Genet 41:89-94. 2009
    ..Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway...
  69. pmc Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
    Nils Halberg
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell Biol 29:4467-83. 2009
    ..Collectively, our observations are consistent with a model in which adipose tissue hypoxia serves as an early upstream initiator for adipose tissue dysfunction by inducing a local state of fibrosis...
  70. ncbi Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study
    Fereidoun Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, P O Box 4763, Tehran 19395, Iran
    Diabetes Res Clin Pract 61:29-37. 2003
    ..This report on the metabolic syndrome from Iran shows a high prevalence of this disorder. Efforts on promoting healthy diets, physical activity, and blood pressure control must be undertaken...
  71. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ....
  72. pmc Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    Jing Xu
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California, USA
    Diabetes 58:250-9. 2009
    ..The aims of the current study are to evaluate the role of FGF21 in energy metabolism and to provide mechanistic insights into its glucose and lipid-lowering effects in a high-fat diet-induced obesity (DIO) model...
  73. pmc Sleep restriction for 1 week reduces insulin sensitivity in healthy men
    Orfeu M Buxton
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes 59:2126-33. 2010
    ..This study tests the hypothesis that decreasing nighttime sleep duration reduces insulin sensitivity and assesses the effects of a drug, modafinil, that increases alertness during wakefulness...
  74. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  75. pmc Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
    Faramarz Ismail-Beigi
    Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
    Lancet 376:419-30. 2010
    ..We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes.
  76. ncbi Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, England
    Arch Intern Med 165:2644-50. 2005
    ..We sought to compare metabolic syndrome (MetS) with the Framingham Risk Score (FRS) as predictors of coronary heart disease (CHD), stroke, and type 2 diabetes mellitus (DM2) in middle-aged men...
  77. pmc Variants in MTNR1B influence fasting glucose levels
    Inga Prokopenko
    1 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK 2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK 3 These authors contributed equally to this work
    Nat Genet 41:77-81. 2009
    ..Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci...
  78. doi Insulin-sensitive obesity
    Nora Kloting
    Department of Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Germany
    Am J Physiol Endocrinol Metab 299:E506-15. 2010
    ..This suggests that mechanisms beyond a positive caloric balance such as inflammation and adipokine release determine the pathological metabolic consequences in patients with obesity...
  79. ncbi Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice
    Hayato Maeda
    Faculty of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate, Hokkaido 041 8611, Japan
    J Agric Food Chem 55:7701-6. 2007
    ..and antidiabetic effects of fucoxanthin and fish oil, we investigated the effect on the WAT weight, blood glucose, and insulin levels of KK- A(y) mice...
  80. ncbi Systematic review: glucose control and cardiovascular disease in type 2 diabetes
    Tanika N Kelly
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA
    Ann Intern Med 151:394-403. 2009
    ..Results from clinical trials examining the effect of intensive glucose control on cardiovascular disease have been conflicting...
  81. ncbi Effect of glycemic carbohydrates on short-term satiety and food intake
    G Harvey Anderson
    Department of Nutritional Sciences, University of Toronto, Fitzgerald Building, 150 College Street, Toronto, Ontario, Canada M5S 3E2
    Nutr Rev 61:S17-26. 2003
    ..g., 2 to 3 hours). There is no consistent evidence that an increase in blood glucose, either acute or sustained, is the primary determinant of their effects on food intake and satiety...
  82. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
    ..Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation of oxidative stress...
  83. ncbi Nocturnal hypertension in mice consuming a high fructose diet
    Vera Farah
    Boonshoft School of Medicine of Wright State University, Department of Pharmacology and Toxicology, Dayton, OH 45401, USA
    Auton Neurosci 130:41-50. 2006
    ..To investigate the effect of fructose consumption on the light/dark pattern of blood pressure, heart rate and autonomic neural function in mice...
  84. pmc The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
    Nicola L Beer
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Hum Mol Genet 18:4081-8. 2009
    ....
  85. ncbi Normal fasting plasma glucose levels and type 2 diabetes in young men
    Amir Tirosh
    Medical Corps Headquarters, Tel Hashomer, Israel
    N Engl J Med 353:1454-62. 2005
    ..55 mmol per liter). Whether higher fasting plasma glucose levels within this range independently predict type 2 diabetes in young adults is unclear...
  86. ncbi The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    Alexei Kharitonenkov
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocrinology 148:774-81. 2007
    ..These data support the development of FGF-21 for the treatment of diabetes and other metabolic diseases...
  87. pmc Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, U K
    Diabetes 58:2703-8. 2009
    ..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
  88. ncbi Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 110:955-61. 2004
    ....
  89. ncbi Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    Janin Berndt
    University of Leipzig, D 04103 Leipzig, Germany
    Diabetes 54:2911-6. 2005
    ..In addition, we did not find differences in visfatin mRNA expression between visceral and subcutaneous adipose tissue in humans...
  90. ncbi Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis
    Paola Brun
    Department of Histology, Univ of Padua, Via Gabelli 63, Padova, Italy
    Am J Physiol Gastrointest Liver Physiol 292:G518-25. 2007
    ..We suggest that in metabolic syndrome, patients may likewise have a greater intestinal mucosa permeability and increased lipopolysaccharide levels in portal blood that can contribute to the liver inflammatory damage...
  91. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  92. ncbi Glucose variability; does it matter?
    Sarah E Siegelaar
    Academic Medical Center, Department of Internal Medicine, Meibergdreef 9, Room F4 255, 1105 AZ Amsterdam, The Netherlands
    Endocr Rev 31:171-82. 2010
    ....
  93. ncbi Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    Claus M Larsen
    Steno Diabetes Center, Gentofte, Denmark
    N Engl J Med 356:1517-26. 2007
    ....
  94. ncbi Evaluating the glucose tolerance test in mice
    Sofianos Andrikopoulos
    Univ of Melbourne, Dept of Medicine, Heidelberg Heights, Victoria, Australia
    Am J Physiol Endocrinol Metab 295:E1323-32. 2008
    ..We conclude that 2 g/kg glucose administered orally following 6 h of fasting is best to assess glucose tolerance in mice under these conditions...
  95. pmc Relationship between blood glucose and carotid intima media thickness: A meta-analysis
    Thomas R Einarson
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:37. 2010
    ..The link has not been established between glucose and CIMT; therefore, we sought to assess the relationship between glucose and CIMT...
  96. ncbi The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:113-21. 2005
    ..The natural history of nonalcoholic fatty liver disease (NAFLD) in the community remains unknown. We sought to determine survival and liver-related morbidity among community-based NAFLD patients...
  97. ncbi Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    Doris A Stoffers
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Clinical Research Building 611B, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Diabetes 52:734-40. 2003
    ..These results indicate that exposure to Ex-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of diabetes in adulthood...
  98. doi Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006
    Bernard M Y Cheung
    Department of Clinical Pharmacology, School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom
    Am J Med 122:443-53. 2009
    ..Changes in the prevalence, treatment, and management of diabetes in the United States from 1999 to 2006 were studied using data from the National Health and Nutrition Examination Survey...
  99. ncbi Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle
    Michale Bouskila
    Am J Physiol Endocrinol Metab 294:E28-35. 2008
    ..This suggests that allosteric regulation of GS by G-6-P may play a key role in insulin-stimulated muscle glycogen synthesis in vivo...
  100. doi Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    Masahito Takikawa
    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487 8501, Japan
    J Nutr 140:527-33. 2010
    ..Dietary BBE significantly reduced the blood glucose concentration and enhanced insulin sensitivity...
  101. pmc Endosperm and whole grain rye breads are characterized by low post-prandial insulin response and a beneficial blood glucose profile
    Liza A H Rosén
    Division of Applied Nutrition and Food Chemistry, Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    Nutr J 8:42. 2009
    ..The objective of this study was to explore the mechanism for a reduced post-prandial insulin demand with rye products...

Research Grants91

  1. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..Diabetes mellitus is a chronic disease that requires daily management to prevent large fluctuations in blood glucose levels and Diabetes disease management as well as biomedical sensor development is prime targets of the NIDDK ..
  2. The effects of glucose on central vagal brainstem circuits
    KIRSTEEN NAIRN BROWNING; Fiscal Year: 2010
    ..b>Blood glucose levels oscillate throughout the day and increase dramatically following food intake;adaptive autonomic sensory ..
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  4. EFFICACY OF MOTIVATIONAL INTERVIEW TO LOWER DIABETES RISK IN AFRICAN AMERICANS
    LEWIS BLUE; Fiscal Year: 2011
    ..S. adults has been increasing and is now about 30.5% (Ford et al., 2004). Pre-diabetics have blood glucose levels that are higher than normal but have not yet risen to the level at which they would indicate a ..
  5. Testosterone stimulation of insulin signalingin adipocytes
    Wayne E Taylor; Fiscal Year: 2010
    ..with a metabolic syndrome of disturbances in lipid and carbohydrate metabolism including obesity, high blood glucose, and insulin resistance...
  6. Testosterone stimulation of insulin signalingin adipocytes
    Wayne Taylor; Fiscal Year: 2009
    ..with a metabolic syndrome of disturbances in lipid and carbohydrate metabolism including obesity, high blood glucose, and insulin resistance...
  7. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert Harris; Fiscal Year: 2009
    ..down regulation of the expression of PDKs is a critical component of the mechanism by which insulin controls blood glucose. Second, PDK knock out mice maintained on a high-fat, diabetogenic diet accumulate less fat in their livers, ..
  8. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2003
    Inadequate control of blood glucose contributes to the complications of diabetes (renal, retinal, neural)...
  9. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2004
    Inadequate control of blood glucose contributes to the complications of diabetes (renal, retinal, neural)...
  10. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2002
    Inadequate control of blood glucose contributes to the complications of diabetes (renal, retinal, neural)...
  11. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..design in which the primary aim will be evaluated by a within-subject comparison of HbA1C, a marker of blood glucose control and demonstrated predictor of diabetes complications and mortality, between baseline and 2 follow-up ..
  12. North Lawndale Diabetes Community Action Project
    Steven Whitman; Fiscal Year: 2009
    ..design in which the primary aim will be evaluated by a within-subject comparison of HbA1C, a marker of blood glucose control and demonstrated predictor of diabetes complications and mortality, between baseline and 2 follow-up ..
  13. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
    ..The specific aims include: (a) examine the effects of 2-chloropropionate on blood glucose, lactate, pyruvate, and alanine of the fasted rat; (b) to determine the effects of 2-chloropropionate on blood ..
  14. NIDDM PRIMARY PREVENTION TRIAL (DPT 2)
    George Bray; Fiscal Year: 2000
    ..These individuals often make normal or increased amounts of insulin but are unable to maintain physiologic blood glucose concentrations because of this defect...
  15. NIDDM PRIMARY PREVENTION TRIAL (DPT 2)
    George Bray; Fiscal Year: 2002
    ..These individuals often make normal or increased amounts of insulin but are unable to maintain physiologic blood glucose concentrations because of this defect...
  16. Glucose monitoring using polarized light
    GERARD COTE; Fiscal Year: 2009
    ..Diabetes mellitus is a chronic disease that requires daily management to prevent large fluctuations in blood glucose levels and Diabetes disease management as well as biomedical sensor development is prime targets of the NIDDK ..
  17. Glucose monitoring using polarized light
    GERARD COTE; Fiscal Year: 2007
    Diabetes mellitus is a chronic disease that requires daily management to prevent large fluctuations in blood glucose levels and Diabetes disease management as well as biomedical sensor development is prime targets of the NIDDK and ..
  18. Effect of exendin-(9-39) on glucose metabolism in subjects with hyperinsulinism
    DIVA DE LEON; Fiscal Year: 2007
    ..Our overall hypothesis is that antagonism of the GLP-1 receptor by exendin-(9-39) will increase fasting blood glucose levels and decrease glucose requirement to maintain euglycemia in subjects with KATP HI as a result of ..
  19. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 1999
    ..retinopathy is a disease of the retinal microvessels that is apparently a consequence of protracted high blood glucose levels...
  20. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 2001
    ..retinopathy is a disease of the retinal microvessels that is apparently a consequence of protracted high blood glucose levels...
  21. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 2000
    ..retinopathy is a disease of the retinal microvessels that is apparently a consequence of protracted high blood glucose levels...
  22. INSULIN-LIKE GF AXIS, INSULIN SECRETION/CARBOHYDRATE USE
    LORRAINE KATZ; Fiscal Year: 2000
    ..The majority of these children had known defects in the beta cell sulfonylurea receptor. All had suboptimal blood glucose levels, and patients served as their own controls...
  23. STRESS MANAGEMENT, INDIVIDUAL DIFFERENCES AND NIDDM
    Richard Surwit; Fiscal Year: 2001
    ..Anxiety patients with NIDDM, determine the relationship between changes in perceived anxiety and changes in blood glucose control in these patients and, in addition, we will perform exploratory analyses to determine if patients with ..
  24. Momentary Biobehavioral Effects on Physical Activity in Adults with T2 Diabetes
    CYNTHIA J FRITSCHI; Fiscal Year: 2010
    ..technology continuously over 6 days to measure physical activity (wrist actigraphy), fatigue (self-report), blood glucose levels (CGM), and related self-care behaviors (nightly diary), alongside retrospective measures of other ..
  25. STRESS MANAGEMENT, INDIVIDUAL DIFFERENCES AND NIDDM
    Richard Surwit; Fiscal Year: 1999
    ..Anxiety patients with NIDDM, determine the relationship between changes in perceived anxiety and changes in blood glucose control in these patients and, in addition, we will perform exploratory analyses to determine if patients with ..
  26. Liver Glycogen in Control of Plasma Glucose
    Katarina Borer; Fiscal Year: 2009
    ..We have recently found that a 20% lowering of blood glucose and altered pancreatic hormone response depend on exercise being performed in fasted/postabsorptive state, as ..
  27. VANADIUM FOR TREATMENT OF NIDDM
    Jean Louis Chiasson; Fiscal Year: 1993
    ..It has only been shown to normalise blood glucose in STZ-diabetic rats...
  28. MAP Kinase Phosphatase 3 (MKP-3) and Obesity-related Gluconeogenesis
    Haiyan Xu; Fiscal Year: 2010
    ..In the insulin resistant diabetic state, blood glucose levels are elevated due to increased glucose production from the liver (mainly through de novo glucose ..
  29. MAP Kinase Phosphatase 3 (MKP-3) and Obesity-related Gluconeogenesis
    Haiyan Xu; Fiscal Year: 2009
    ..In the insulin resistant diabetic state, blood glucose levels are elevated due to increased glucose production from the liver (mainly through de novo glucose ..
  30. MAP Kinase Phosphatase 3 (MKP-3) and Obesity-related Gluconeogenesis
    Haiyan Xu; Fiscal Year: 2010
    ..In the insulin resistant diabetic state, blood glucose levels are elevated due to increased glucose production from the liver (mainly through de novo glucose ..
  31. Red Blood Cell Fatty Acid Biomarkers and Cardiovascular Disease Risk
    William Harris; Fiscal Year: 2009
    ..FA levels over several weeks and are less variable (analogous to hemoglobin A1C in the assessment of average blood glucose levels)...
  32. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2003
    ..will examine the complex relationships between race, diabetes self-management (including self-monitoring of blood glucose and diabetes drug therapy), glycemic control, and diabetes complications in a managed care setting over a nine-..
  33. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2002
    ..will examine the complex relationships between race, diabetes self-management (including self-monitoring of blood glucose and diabetes drug therapy), glycemic control, and diabetes complications in a managed care setting over a nine-..
  34. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2004
    ..will examine the complex relationships between race, diabetes self-management (including self-monitoring of blood glucose and diabetes drug therapy), glycemic control, and diabetes complications in a managed care setting over a nine-..
  35. Red Blood Cell Fatty Acid Biomarkers and Cardiovascular Disease Risk
    William S Harris; Fiscal Year: 2010
    ..FA levels over several weeks and are less variable (analogous to hemoglobin A1C in the assessment of average blood glucose levels)...
  36. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2003
    ..will examine the complex relationships between race, diabetes self-management (including self-monitoring of blood glucose and diabetes drug therapy), glycemic control, and diabetes complications in a managed care setting over a nine-..
  37. Blood Glucose Training for Women with Type 1 Diabetes Contemplating Pregnancy
    Lee M Ritterband; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ineffective management of blood glucose (BG) levels during preconception and pregnancy has been associated with severe maternal and fetal complications...
  38. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DE LEON; Fiscal Year: 2009
    ..Our overall hypothesis is that antagonism of the GLP-1 receptor by exendin-(9-39) will increase fasting blood glucose levels, prevent protein-induced hypoglycemia and decrease glucose requirement to maintain euglycemia in ..
  39. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..Our overall hypothesis is that antagonism of the GLP-1 receptor by exendin-(9-39) will increase fasting blood glucose levels, prevent protein-induced hypoglycemia and decrease glucose requirement to maintain euglycemia in ..
  40. ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION
    Show Ling Shyng; Fiscal Year: 2010
    ATP-sensitive potassium (KATP) channels in pancreatic b-cells couple blood glucose concentrations to membrane excitability thus control insulin secretion...
  41. ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION
    Show Ling Shyng; Fiscal Year: 2009
    ATP-sensitive potassium (KATP) channels in pancreatic b-cells couple blood glucose concentrations to membrane excitability thus control insulin secretion...
  42. Endothelial Function Predictors in Adolescent Diabetes
    Robert Hoffman; Fiscal Year: 2009
    ..function in adolescents with type 1 diabetes and 2) to determine the relationship of glycemic control and blood glucose variability as determined from continuous glucose monitoring to endothelial function in healthy type 1 ..
  43. DIETARY TREATMENT OF DIABETES MELITUS--META ANALYSIS
    Zung Tran; Fiscal Year: 1990
    ..modifications can affect the metabolic control and the lipid profile in NIDDM patients favorably by regulating blood glucose, by reducing total cholesterol, triglycerides, and low density lipoprotein-cholesterol and by elevating high ..
  44. Endothelial Function Predictors in Adolescent Diabetes
    ROBERT PAUL HOFFMAN; Fiscal Year: 2010
    ..function in adolescents with type 1 diabetes and 2) to determine the relationship of glycemic control and blood glucose variability as determined from continuous glucose monitoring to endothelial function in healthy type 1 ..
  45. Contracting and monitoring relationships between adolescents with type I diabetes
    Aaron Carroll; Fiscal Year: 2009
    ..patients, notably adolescents, have poor self-management practices that result in suboptimal control of their blood glucose levels...
  46. MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
    Boris Kovatchev; Fiscal Year: 2009
    DESCRIPTION: By nature, the development of a closed-loop system (known as artificial pancreas) controlling blood glucose (BG) in diabetes is an interdisciplinary project involving physiology, behavioral science, and engineering...
  47. MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
    Boris P Kovatchev; Fiscal Year: 2010
    DESCRIPTION: By nature, the development of a closed-loop system (known as artificial pancreas) controlling blood glucose (BG) in diabetes is an interdisciplinary project involving physiology, behavioral science, and engineering...
  48. Nkx2.2 in Pancreatic Development: The Role of the NK2-SD Domain
    JOSHUA ADAM LEVINE; Fiscal Year: 2012
    ..The endocrine pancreas, composed of the islets of Langerhans, is responsible for the maintenance of blood glucose homeostasis. Several cell types comprise the islets and include glucagon-producing ...
  49. Use of Continuous Glucose Sensors in Adolescents with Inadequate Diabetic Control
    Tim Wysocki; Fiscal Year: 2011
    ..quality and quantity of glucose data could be an excellent adjunct to conventional self-monitoring of blood glucose, permitting more informed diabetes decision-making...
  50. EARLY MICROVASCULAR CHANGES IN DIABETIC NEUROPATHY
    Ananda Weerasuriya; Fiscal Year: 1992
    ....
  51. Use of Continuous Glucose Sensors in Adolescents with Inadequate Diabetic Control
    Tim Wysocki; Fiscal Year: 2010
    ..quality and quantity of glucose data could be an excellent adjunct to conventional self-monitoring of blood glucose, permitting more informed diabetes decision-making...
  52. Use of Continuous Glucose Sensors in Adolescents with Inadequate Diabetic Control
    Tim Wysocki; Fiscal Year: 2009
    ..quality and quantity of glucose data could be an excellent adjunct to conventional self-monitoring of blood glucose, permitting more informed diabetes decision-making...
  53. Novel Glucagon Modulators and the Closed Loop System
    Rubina Heptulla; Fiscal Year: 2009
    ..This method relies on the patient being engaged in blood glucose monitoring and insulin delivery, especially for meal boluses...
  54. Promoting "Stories of Success": Enhancing Diabetes Self-Care
    Sharon Utz; Fiscal Year: 2009
    ..A majority of adults with diabetes do not achieve recommended target levels of blood glucose, blood pressure and/or serum lipids, putting them at risk for complications such as cardiovascular and renal ..
  55. Recruitment of bone marrow-derived cells required for beta cell regeneration
    Kristie Aamodt; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Restoring ? cell mass in patients with diabetes would provide the blood glucose regulation necessary to greatly reduce their risk of developing long-term complications such as heart disease, ..
  56. Neuroendocrinology of Energy Balance Control
    Matthew R Hayes; Fiscal Year: 2012
    ..GLP-1 receptor (GLP-1R) agonists for the treatment of Type II Diabetes Mellitus (T2DM) produce improvements in blood glucose regulation and, in addition, produce meaningful reductions in food intake and body weight in both humans and ..
  57. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2010
    ..We have determined that our protocol appears to be an efficient means to maintain our target blood glucose levels of 80-140 mg/dL without increasing rates of hypoglycemia...
  58. GLYCEMIC INDEX/GLYCEMIC LOAD AND BLOOD LIPIDS IN THE WHI
    James Shikany; Fiscal Year: 2003
    ..Recent evidence suggest that diets abundant in high-starch carbohydrates may have an adverse effect on blood glucose and insulin concentrations, resulting in alterations of blood lipids that may increase the risk of developing ..
  59. GLYCEMIC INDEX/GLYCEMIC LOAD AND BLOOD LIPIDS IN THE WHI
    James Shikany; Fiscal Year: 2004
    ..Recent evidence suggest that diets abundant in high-starch carbohydrates may have an adverse effect on blood glucose and insulin concentrations, resulting in alterations of blood lipids that may increase the risk of developing ..
  60. Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial
    Anil Sapru; Fiscal Year: 2012
    ..Since the parent trial will not collect any blood samples other than for confirmation of blood glucose, we will approach parents or surrogates of children enrolled in the HALF PINT trial and obtain informed ..
  61. Mexican-American Trial of Community Health Workers-MATCH
    Steven Rothschild; Fiscal Year: 2005
    ..Trials show that self-management behaviors (self monitoring of blood glucose, taking medications as prescribed, and periodic scheduled clinic attendance) can make a positive difference in ..
  62. Mexican-American Trial of Community Health Workers-MATCH
    Steven Rothschild; Fiscal Year: 2004
    ..Trials show that self-management behaviors (self monitoring of blood glucose, taking medications as prescribed, and periodic scheduled clinic attendance) can make a positive difference in ..
  63. Novel Puerarin Analogs with Anti-Diabetic Activity
    NICHOLAS CAIRNS; Fiscal Year: 2007
    ..and/or promoting glucose disposal in the tissues may be beneficial for diabetic patients to control the blood glucose level in the postprandial state...
  64. VANADIUM SALTS IN TREATMENT OF DIABETES
    C Kahn; Fiscal Year: 1993
    ..When given orally, vanadate dramatically improves or normalizes blood glucose in virtually every animal model of diabetes mellitus which has been studied, including the streptozotocin ..
  65. Mexican-American Trial of Community Health Workers-MATCH
    Steven Rothschild; Fiscal Year: 2007
    ..Trials show that self-management behaviors (self monitoring of blood glucose, taking medications as prescribed, and periodic scheduled clinic attendance) can make a positive difference in ..
  66. Mexican-American Trial of Community Health Workers-MATCH
    Steven Rothschild; Fiscal Year: 2006
    ..Trials show that self-management behaviors (self monitoring of blood glucose, taking medications as prescribed, and periodic scheduled clinic attendance) can make a positive difference in ..
  67. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2007
    ..Precise control of blood glucose by cortisol is essential because this sugar is the brain's primary energy source...
  68. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2004
    ..Precise control of blood glucose by cortisol is essential because this sugar is the brain's primary energy source...
  69. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2005
    ..Precise control of blood glucose by cortisol is essential because this sugar is the brain's primary energy source...
  70. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2006
    ..Precise control of blood glucose by cortisol is essential because this sugar is the brain's primary energy source...
  71. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 1999
    ..of DN and recent clinical trials have shown a reduction in the progression of DN with careful control of blood glucose an intensive insulin therapy. However even excellent glycemic control fails to prevent or reverse DN...
  72. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 2000
    ..of DN and recent clinical trials have shown a reduction in the progression of DN with careful control of blood glucose an intensive insulin therapy. However even excellent glycemic control fails to prevent or reverse DN...
  73. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 2001
    ..of DN and recent clinical trials have shown a reduction in the progression of DN with careful control of blood glucose an intensive insulin therapy. However even excellent glycemic control fails to prevent or reverse DN...
  74. Statistical Functional Data Analysis Models of Glucose and Insulin Kinetics
    Inna Chervoneva; Fiscal Year: 2010
    ..and hypoglycemia in patients now manually controlling the insulin delivery rate depending on the current blood glucose level and expected consumption of carbohydrates...
  75. Primary Prevention of Weight Gain for Women Aged 25-45
    Walter Willett; Fiscal Year: 2002
    ..Many studies have demonstrated changes in blood glucose levels due to the intake of specific carbohydrate foods, as measured by glycemic index (GI)...
  76. Statistical Functional Data Analysis Models of Glucose and Insulin Kinetics
    Inna Chervoneva; Fiscal Year: 2009
    ..and hypoglycemia in patients now manually controlling the insulin delivery rate depending on the current blood glucose level and expected consumption of carbohydrates...
  77. Primary Prevention of Weight Gain for Women Aged 25-45
    Walter Willett; Fiscal Year: 2003
    ..Many studies have demonstrated changes in blood glucose levels due to the intake of specific carbohydrate foods, as measured by glycemic index (GI)...
  78. Primary Prevention of Weight Gain for Women Aged 25-45
    Walter Willett; Fiscal Year: 2004
    ..Many studies have demonstrated changes in blood glucose levels due to the intake of specific carbohydrate foods, as measured by glycemic index (GI)...
  79. Hypo-Lipidemic Actions of Creosote Bush-Derived NDGA
    Salman Azhar; Fiscal Year: 2009
    ..LO) inhibitor, has profound effects on multiple components of the metabolic syndrome including lowering of blood glucose, free fatty acids (FFA) and triglyceride levels, attenuation of elevated blood pressure and improvement in ..
  80. Momentary Biobehavioral Effects on Physical Activity in Adults with T2 Diabetes
    CYNTHIA J FRITSCHI; Fiscal Year: 2012
    ..technology continuously over 6 days to measure physical activity (wrist actigraphy), fatigue (self-report), blood glucose levels (CGM), and related self-care behaviors (nightly diary), alongside retrospective measures of other ..
  81. Dopamine action in pancreatic islet function
    David W Piston; Fiscal Year: 2010
    ..b>Blood glucose homeostasis depends on glucose-stimulated insulin secretion (GSIS) from islet 2 cells, but we also know that ..
  82. Self-Cleaning Sensor Membranes to Improve Glucose Monitoring In Vivo
    MELISSA GRUNLAN; Fiscal Year: 2010
    ..There is an unmet need to develop a biosensor technology that is a fast and convenient way to monitor blood glucose in diabetics...
  83. Self-Cleaning Sensor Membranes to Improve Glucose Monitoring In Vivo
    MELISSA GRUNLAN; Fiscal Year: 2009
    ..There is an unmet need to develop a biosensor technology that is a fast and convenient way to monitor blood glucose in diabetics...
  84. GLUCONEOGENESIS AND MITOCHONDRIAL FUNCTION IN SHOCK
    Robert Rhodes; Fiscal Year: 1980
    ..b>Blood glucose, hepatic glycogen, ATP, ADP, lactate, inorganic phosphate, and phosphoenolypyruvate (PEP) will be determined...
  85. CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic Failure
    Dianne Lattemann; Fiscal Year: 2009
    ..It is characterized by impairment of both the sensing of symptoms of falling blood glucose and the neuroendocrine counterregulatory response (CRR), a hormonal and neural response that includes ..
  86. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2003
    Insulin lowers blood glucose by stimulating glucose uptake and storage in various target tissues, the most important being liver, skeletal muscle, and fat. The failure to respond appropriately to insulin results in a rise in blood sugar...
  87. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2004
    Insulin lowers blood glucose by stimulating glucose uptake and storage in various target tissues, the most important being liver, skeletal muscle, and fat. The failure to respond appropriately to insulin results in a rise in blood sugar...
  88. REGULATION OF GENE EXPRESSION BY INSULIN-MIMETIC AGENTS
    Susan Stapleton; Fiscal Year: 1992
    ..investigator's abstract): Insulin has been shown to regulate many cellular processes including the control of blood glucose levels...
  89. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2001
    Insulin lowers blood glucose by stimulating glucose uptake and storage in various target tissues, the most important being liver, skeletal muscle, and fat. The failure to respond appropriately to insulin results in a rise in blood sugar...