monosaccharides

Summary

Summary: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)

Top Publications

  1. ncbi Glycol-cleavage oxidation
    Arthur S Perlin
    Department of Chemistry, McGill University, Montreal, Canada, PQ H3A 2K6
    Adv Carbohydr Chem Biochem 60:183-250. 2006
  2. ncbi Structural basis for substrate binding and regioselective oxidation of monosaccharides at C3 by pyranose 2-oxidase
    Magdalena Kujawa
    School of Biotechnology, Royal Institute of Technology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    J Biol Chem 281:35104-15. 2006
  3. ncbi Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation
    Jeffrey A Smith
    Center for Cell Signaling, Department of Pathology, University of Virginia Health Science Center, 7041 Multistory Building, Charlottesville, VA 22908 0577, USA
    Cancer Res 65:1027-34. 2005
  4. ncbi Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers
    Anna L Stratford
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    Stem Cells 30:1338-48. 2012
  5. ncbi Arsenic metabolites in human urine after ingestion of an arsenosugar
    Kevin A Francesconi
    Institute of Biology, University of Southern Denmark, 5230 Odense M, Denmark
    Clin Chem 48:92-101. 2002
  6. pmc Additive empirical force field for hexopyranose monosaccharides
    Olgun Guvench
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 20 Penn St, HSF II 629, Baltimore, Maryland 21201, USA
    J Comput Chem 29:2543-64. 2008
  7. ncbi GlycoMod--a software tool for determining glycosylation compositions from mass spectrometric data
    C A Cooper
    Proteome Systems Ltd, Locked Bag 2073, North Ryde, Sydney, NSW 1670, Australia
    Proteomics 1:340-9. 2001
  8. ncbi Free energy landscapes of iduronic acid and related monosaccharides
    Benedict M Sattelle
    Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    J Am Chem Soc 132:13132-4. 2010
  9. ncbi Conformational analysis of furanose rings with PSEUROT: parametrization for rings possessing the arabino, lyxo, ribo, and xylo stereochemistry and application to arabinofuranosides
    Justin B Houseknecht
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    J Org Chem 67:4647-51. 2002
  10. ncbi Contribution of simple saccharides to the stabilization of amyloid structure
    Justin Fung
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ont, M5S 3H2, Canada
    Biochem Biophys Res Commun 328:1067-72. 2005

Detail Information

Publications258 found, 100 shown here

  1. ncbi Glycol-cleavage oxidation
    Arthur S Perlin
    Department of Chemistry, McGill University, Montreal, Canada, PQ H3A 2K6
    Adv Carbohydr Chem Biochem 60:183-250. 2006
  2. ncbi Structural basis for substrate binding and regioselective oxidation of monosaccharides at C3 by pyranose 2-oxidase
    Magdalena Kujawa
    School of Biotechnology, Royal Institute of Technology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    J Biol Chem 281:35104-15. 2006
    ..We also substantiate our hypothesis with steady-state kinetics data for the alanine replacements of Asp452 and Arg472 as well as the double alanine 452/472 mutant...
  3. ncbi Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation
    Jeffrey A Smith
    Center for Cell Signaling, Department of Pathology, University of Virginia Health Science Center, 7041 Multistory Building, Charlottesville, VA 22908 0577, USA
    Cancer Res 65:1027-34. 2005
    ..SL0101 will provide a powerful new tool to dissect the molecular functions of RSK in cancer cells...
  4. ncbi Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers
    Anna L Stratford
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    Stem Cells 30:1338-48. 2012
    ..In conclusion, RSK2 inhibition provides a novel therapeutic avenue for TNBC and holds the promise of eliminating TICs...
  5. ncbi Arsenic metabolites in human urine after ingestion of an arsenosugar
    Kevin A Francesconi
    Institute of Biology, University of Southern Denmark, 5230 Odense M, Denmark
    Clin Chem 48:92-101. 2002
    ..Arsenic-containing carbohydrates (arsenosugars) are common constituents of marine algae, including those species used as human food. The toxicology of these compounds has not been fully evaluated...
  6. pmc Additive empirical force field for hexopyranose monosaccharides
    Olgun Guvench
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 20 Penn St, HSF II 629, Baltimore, Maryland 21201, USA
    J Comput Chem 29:2543-64. 2008
    ..and condensed-phase properties of small-molecule model compounds corresponding to fragments of pyranose monosaccharides. The resultant parameters are transferred to the full pyranose monosaccharides, and additional parameter ..
  7. ncbi GlycoMod--a software tool for determining glycosylation compositions from mass spectrometric data
    C A Cooper
    Proteome Systems Ltd, Locked Bag 2073, North Ryde, Sydney, NSW 1670, Australia
    Proteomics 1:340-9. 2001
    ..of any glycoprotein-derived oligosaccharide comprised of either underivatised, methylated or acetylated monosaccharides, or with a derivatised reducing terminus...
  8. ncbi Free energy landscapes of iduronic acid and related monosaccharides
    Benedict M Sattelle
    Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    J Am Chem Soc 132:13132-4. 2010
    ..In order to resolve this enigma, we have calculated the free energy landscape of IdoA and two related monosaccharides from extensive microsecond simulations...
  9. ncbi Conformational analysis of furanose rings with PSEUROT: parametrization for rings possessing the arabino, lyxo, ribo, and xylo stereochemistry and application to arabinofuranosides
    Justin B Houseknecht
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    J Org Chem 67:4647-51. 2002
    ..for the arabinofuranose ring were used in PSEUROT calculations to determine the conformers populated by monosaccharides 1 and 2 as well as the furanose rings in oligosaccharides 9-15...
  10. ncbi Contribution of simple saccharides to the stabilization of amyloid structure
    Justin Fung
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ont, M5S 3H2, Canada
    Biochem Biophys Res Commun 328:1067-72. 2005
    ..Our studies suggest that utilization of a combinatorial strategy to alter H-bonding capacity across a simple carbohydrate molecule may represent a novel drug design strategy...
  11. ncbi Recognition of selected monosaccharides by Pseudomonas aeruginosa Lectin II analyzed by molecular dynamics and free energy calculations
    Navnit Kumar Mishra
    National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Carbohydr Res 345:1432-41. 2010
    In this study, interactions of selected monosaccharides with the Pseudomonas aeruginosa Lectin II (PA-IIL) are analyzed in detail...
  12. ncbi Kinsenoside isolated from Anoectochilus formosanus suppresses LPS-stimulated inflammatory reactions in macrophages and endotoxin shock in mice
    Hung Bo Hsiao
    Department of Life Science, National Chung Hsing University, Taichung, Taiwan
    Shock 35:184-90. 2011
    ..In conclusion, kinsenoside inhibited the production of inflammatory mediators and enhanced anti-inflammatory cytokine generation. Therefore, kinsenoside can alleviate acute inflammatory hazards...
  13. ncbi Arsinothioyl-sugars produced by in vitro incubation of seaweed extract with liver cytosol analysed by HPLC coupled simultaneously to ES-MS and ICP-MS
    Helle R Hansen
    Department of Chemistry, College of Physical Science, University of Aberdeen, AB24 3UE, UK
    Analyst 129:1058-64. 2004
    ..Here, arsinothioyl sugars are detected for the first time. The in vitro formation of arsinothioyl-sugars in liver cytosol suggests that arsinothioyls may be of large biochemical and toxicological importance...
  14. ncbi In vitro biotransformation of an arsenosugar by mouse anaerobic cecal microflora and cecal tissue as examined using IC-ICP-MS and LC-ESI-MS/MS
    Sean D Conklin
    US EPA, ORD, NERL, Microbiological and Chemical Exposure Assessment Research Division, Cincinnati, OH 45268, USA
    Analyst 131:648-55. 2006
    ..This biotransformation may affect the subsequent absorption, metabolism, and disposition of arsenic present in arsenosugars...
  15. ncbi Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats
    Yonghui Zhang
    Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China
    J Ethnopharmacol 114:141-5. 2007
    ..The OGTT evidenced that this compound could promote the glucose tolerance of acute glucose increase in both diabetic and normal healthy rats...
  16. ncbi Individual variability in the human metabolism of an arsenic-containing carbohydrate, 2',3'-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-beta-D-riboside, a naturally occurring arsenical in seafood
    Reingard Raml
    Institute of Chemistry, Analytical Chemistry, Karl Franzens University Graz, Universitaetsplatz 1, 8010 Graz, Austria
    Chem Res Toxicol 22:1534-40. 2009
    ..The large variability in the way individuals metabolize arsenosugars has implications for risk assessment of arsenic intake from seafood...
  17. ncbi Effects of cellulose crystallinity, hemicellulose, and lignin on the enzymatic hydrolysis of Miscanthus sinensis to monosaccharides
    Makoto Yoshida
    Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Biosci Biotechnol Biochem 72:805-10. 2008
    ..of cellulose crystallinity, hemicellulose, and lignin on the enzymatic hydrolysis of Miscanthus sinensis to monosaccharides were investigated...
  18. ncbi Beta-propeller crystal structure of Psathyrella velutina lectin: an integrin-like fungal protein interacting with monosaccharides and calcium
    Gianluca Cioci
    Centre de Recherches sur les Macromolécules Végétales affiliated with Université Joseph Fourier, CNRS, F 38041 Grenoble, France
    J Mol Biol 357:1575-91. 2006
    ..In the complex with N-acetylglucosamine, six monosaccharides are bound in pockets located between two consecutive propeller blades...
  19. ncbi Structural basis of high-affinity glycan recognition by bacterial and fungal lectins
    Anne Imberty
    CERMAV CNRS affiliated with Université Joseph Fourier, Grenoble BP53, F 38041 Grenoble Cedex 09, France
    Curr Opin Struct Biol 15:525-34. 2005
    ..sites, with some bacterial lectins displaying unusually high affinity for oligosaccharides and even monosaccharides. Analysis of the thermodynamic contributions to the energy of binding gives clues to the strategies used by ..
  20. ncbi A catalytic one-step process for the chemo- and regioselective acylation of monosaccharides
    Takeo Kawabata
    Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan
    J Am Chem Soc 129:12890-5. 2007
    An organocatalytic method for the chemo- and regioselective acylation of monosaccharides has been developed...
  21. ncbi Kinetic and chemical studies on the isomerization of monosaccharides in N-methylmorpholine-N-oxide (NMMO) under Lyocell conditions
    Immanuel Adorjan
    Christian Doppler Laboratory, Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Muthgasse 18, A 1190 Vienna, Austria
    Carbohydr Res 339:1899-906. 2004
    ..In the present work, the reactions of monosaccharides under Lyocell conditions were investigated in detail, using capillary zone electrophoresis as the analytical ..
  22. ncbi Development of a mass fingerprinting tool for automated interpretation of oligosaccharide fragmentation data
    Hiren J Joshi
    Proteome Systems, Sydney, NSW, Australia
    Proteomics 4:1650-64. 2004
    ....
  23. ncbi Minimization of carbon addition during derivatization of monosaccharides for compound-specific delta13C analysis in environmental research
    Simone Gross
    Institute of Soil Science and Soil Geography, University of Bayreuth, D 95440 Bayreuth, Germany
    Rapid Commun Mass Spectrom 18:2753-64. 2004
    Little is known about the delta13C composition of monosaccharides representing the largest carbon reservoir in the biosphere...
  24. ncbi Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy
    Desiree A Thayer
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Chem Asian J 1:445-52. 2006
    ....
  25. ncbi Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugar
    Paul Andrewes
    U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 38:4140-8. 2004
    ....
  26. ncbi Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures
    Charles Sabin
    CERMAV CNRS affiliated with Université Joseph Fourier, 601 rue de la Chimie, Grenoble BP53, F 38041 Grenoble Cedex 09, France
    FEBS Lett 580:982-7. 2006
    ..A combination of the structures and thermodynamics provided clues for the role of the hydrophobic group in affinity...
  27. ncbi Adsorption behavior of selected monosaccharides onto an alumina interface
    Kaman Singh
    Physical Chemistry Department, National Sugar Institute, Ministry of Food and Consumer Affairs, Kanpur 208 017, India
    J Colloid Interface Sci 270:21-8. 2004
    ..This is found to be consistent with the chelation behaviour of monosaccharides as found in the OMC of monosaccharides...
  28. ncbi Localization of specific monosaccharides in cells of the brown alga Padina gymnospora and the relation to heavy-metal accumulation
    Leonardo T Salgado
    Laboratório de Biomineralização, Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    Protoplasma 225:123-8. 2005
    ..The main purpose of this work was to determine the localization of specific monosaccharides in P. gymnospora cells...
  29. ncbi Arsenosugars in raw and cooked edible seaweed: characterization and bioaccessibility
    Concepción Almela
    Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Apartado 73, 46100 Burjassot, Spain
    J Agric Food Chem 53:7344-51. 2005
    ..In all of the seaweeds analyzed, arsenosugar bioaccessibility was high (>80%) and did not vary as a result of cooking. Arsenosugar degradation as a result of in vitro digestion was not observed...
  30. ncbi Analytical methods for the determination of arsenosugars--a review of recent trends and developments
    Claudia Niegel
    Universitat Regensburg, Institut für Analytische Chemie, Chemo und Biosensorik, 93053 Regensburg, Germany
    Anal Chim Acta 657:83-99. 2010
    ..The typical experimental approaches for sample pre-treatment, extraction, separation and detection are discussed. Current possibilities and limitations of modern instrumental techniques are pointed out...
  31. ncbi Critical review or scientific opinion paper: arsenosugars--a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?
    Jorg Feldmann
    TESLA Trace Element Speciation Laboratory, University of Aberdeen, Aberdeen, AB24 3UE, Scotland, UK
    Anal Bioanal Chem 399:1735-41. 2011
    ....
  32. ncbi Arsenosugar induced blood and brain oxidative stress, DNA damage and neurobehavioral impairments
    Muhammad Shahdaat Bin Sayeed
    Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh
    Neurochem Res 38:405-12. 2013
    ..This might be responsible for the dysfunction of cognitive and motor functions. However, further investigation is suggested for deciphering the biomolecular mechanism...
  33. ncbi Quantification of monosaccharides through multiple-reaction monitoring liquid chromatography/mass spectrometry using an aminopropyl column
    Loubna A Hammad
    METACyt Biochemical Analysis Center, Department of Chemistry, Indiana University, Bloomington, IN 47405, USA
    Rapid Commun Mass Spectrom 24:1565-74. 2010
    ..chromatography/tandem mass spectrometry (LC/MS/MS) method was designed for the simultaneous quantification of monosaccharides derived from glycoprotein and blood serum using a multiple-reaction monitoring (MRM) approach...
  34. ncbi Stereoelectronic and solvation effects determine hydroxymethyl conformational preferences in monosaccharides
    Christopher B Barnett
    Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
    J Phys Chem B 112:15450-9. 2008
    ..A preference for gauche conformations is observed in monosaccharides, but the reasons for this are not understood...
  35. ncbi Pharmacologically active compounds in the Anoectochilus and Goodyera species
    Xiao Ming Du
    Seiwa Pharmaceuticals Ltd, 1 12 15 Shiba Daimon, Minato ku, Tokyo, 105 8585, Japan
    J Nat Med 62:132-48. 2008
    ..In contrast, these levels were suppressed in 9- and 10-treated groups. Goodyerin (11), a new typical flavone glycoside, exhibited a significant and dose-dependent sedative and anticonvulsant effect...
  36. ncbi Examination of the effect of structural variation on the N-glycosidic torsion (PhiN) among N-(beta-D-glycopyranosyl)acetamido and propionamido derivatives of monosaccharides based on crystallography and quantum chemical calculations
    Mohamed Mohamed Naseer Ali
    CERMAV CNRS, Domaine Universitaire de Grenoble, BP 53, F 38041 Grenoble, France
    Carbohydr Res 344:355-61. 2009
    ..X-ray crystallographic study of several beta-1-N-acetamido- and propionamido derivatives of monosaccharides has earlier shown that the N-glycosidic torsion, Phi(N), is influenced to a larger extent by the structural ..
  37. ncbi Chemical composition and structural features of the macromolecular components of plantation Acacia mangium wood
    Paula C Pinto
    CICECO and Department of Chemistry, University of Aveiro, 3810 193 Aveiro, Portugal
    J Agric Food Chem 53:7856-62. 2005
    ..X-ray diffraction analysis of cellulose (46% wood weight), isolated according to the Kürschner-Hoffer method, showed a degree of crystallinity of 67.6%...
  38. ncbi The hepatoprotective activity of kinsenoside from Anoectochilus formosanus
    Jin Bin Wu
    Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taiwan, ROC
    Phytother Res 21:58-61. 2007
    ....
  39. ncbi Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation
    Henry N Yu
    Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Org Lett 6:723-6. 2004
    ..An improved approach to synthesizing azido-glucose thioglycoside donor to render azido-sugar from mannose via nucleophilic substitution is described. [reaction: see text]..
  40. ncbi Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography
    Xingbin Yang
    Department of Pharmacology, The Fourth Military Medical University, Xi an 710032, P R China
    Anal Sci 21:1177-80. 2005
    ..In this method, APF were hydrolyzed into component monosaccharides and subsequently labeled with 1-phenyl-3-methyl-5-pyrazolone (PMP), and then the labeled monosaccharide ..
  41. ncbi Inhibition of the bacterial lectins of Pseudomonas aeruginosa with monosaccharides and peptides
    H Gustke
    Department of Anatomy II Experimental Morphology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Eur J Clin Microbiol Infect Dis 31:207-15. 2012
    ..The aim of this study was to determine by ciliary beat frequency (CBF) analysis whether monosaccharides or peptides mimicking glycostructures represent blockers of PA lectin binding to human airway cilia...
  42. ncbi Cell wall carbohydrates from fruit pulp of Argania spinosa: structural analysis of pectin and xyloglucan polysaccharides
    Sophie Aboughe-Angone
    UMR CNRS 6037, IFRMP23, Universite de Rouen, Mont Saint Aignan 76821, France
    Carbohydr Res 343:67-72. 2008
    ..Finally, the isolation and analysis of arabinogalactan-proteins showed that Argania fruit pulp is rich in these proteoglycans...
  43. ncbi Genome of an endosymbiont coupling N2 fixation to cellulolysis within protist cells in termite gut
    Yuichi Hongoh
    Ecomolecular Biorecycling Science Research Team, RIKEN Advanced Science Institute, Saitama 351 0198, Japan
    Science 322:1108-9. 2008
    ..Thus, nitrogen fixation and cellulolysis are coupled within the protist's cells. This highly evolved symbiotic system probably underlies the ability of the worldwide pest termites Coptotermes to use wood as their sole food...
  44. ncbi Metabolism of arsenic by sheep chronically exposed to arsenosugars as a normal part of their diet. 1. Quantitative intake, uptake, and excretion
    H R Hansen
    Environmental Analytical Chemistry, Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen AB24 3UE, U K
    Environ Sci Technol 37:845-51. 2003
    ....
  45. ncbi Molecular dynamics study of Pseudomonas aeruginosa lectin-II complexed with monosaccharides
    Navnit Kumar Mishra
    National Centre for Biomolecular Research, Faculty of Science, Kotlarska 2, Masaryk University, 611 37 Brno, Czech Republic
    Proteins 72:382-92. 2008
    ..dynamics simulations on Pseudomonas aeruginosa lectin-II (PA-IIL) and its complexes with four different monosaccharides. We compare the saccharide-free, saccharide-occupied, and saccharide- and ion-free forms of the lectin...
  46. ncbi Determination of monosaccharides and disaccharides in mucopolysaccharidoses patients by electrospray ionisation mass spectrometry
    Steven L Ramsay
    Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Women s and Children s Hospital, North Adelaide, SA 5006, Australia
    Mol Genet Metab 78:193-204. 2003
    ..This paper reports a sensitive and simple method for the measurement of sulfated N-acetylhexosamines and sulfated disaccharides shown to be elevated in some mucopolysaccharidosis and multiple sulfatase deficient patients...
  47. pmc Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
    Anna L Stratford
    Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Breast Cancer Res 10:R99. 2008
    ..Using Motifscan we identified p90 ribosomal S6 kinase (RSK) as a potential candidate for activating YB-1...
  48. ncbi Novel thioarsenic metabolites in human urine after ingestion of an arsenosugar, 2',3'-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-beta-D-riboside
    Reingard Raml
    Institute of Chemistry Analytical Chemistry, Karl Franzens University Graz, Austria
    Chem Res Toxicol 18:1444-50. 2005
    ..Cytotoxicity testing of the major metabolites DMA, oxo-DMAE, thio-DMAE, oxo-DMAA, and thio-DMAA showed that they were nontoxic even at 10 mM, except for DMA, which showed some toxic effects at 1 mM...
  49. ncbi Tailor-made fructooligosaccharides by a combination of substrate and genetic engineering
    Alga Zuccaro
    Department of Microbiology, Technical University of Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
    Chembiochem 9:143-9. 2008
    ..synthesis of tailor-made saccharides of the important 1-kestose and 1-nystose type headed with different monosaccharides of interest. These novel compounds have been isolated...
  50. ncbi Thermodynamics of the interaction of RbCl with some monosaccharides (D-glucose, D-galactose, D-xylose, and D-arabinose) in aqueous solutions at 298.15K
    Yucheng Jiang
    College of Chemistry and Materials Science, Shaanxi Normal University, Xi an, Shaanxi 710062, PR China
    Carbohydr Res 341:262-9. 2006
    The Gibbs energy interaction parameters of RbCl with some monosaccharides (D-glucose, D-galactose, D-xylose, and D-arabinose) in water, g(ES), were obtained from electromotive force (emf) measurements of the electrochemical cell without ..
  51. pmc Statistical analysis of the Bacterial Carbohydrate Structure Data Base (BCSDB): characteristics and diversity of bacterial carbohydrates in comparison with mammalian glycans
    Stephan Herget
    Core Facility Molecular Structure Analysis W160, German Cancer Research Center, Heidelberg, Germany
    BMC Struct Biol 8:35. 2008
    ..Since bacterial glycans are typically displayed at the cell surface, they can interact with the environment and, therefore, have significant biomedical importance...
  52. ncbi Determination of 3-O- and 4-O-methylated monosaccharide constituents in snail glycans
    Herwig Stepan
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Carbohydr Res 345:1504-7. 2010
    ..Furthermore, three different methylated sugars were detected: 3-O-methyl-mannose and 3-O-methyl-galactose were confirmed to be a common snail feature; 4-O-methyl-galactose was detected for the first time in snails...
  53. ncbi Experimental and theoretical studies of sodium cation interactions with D-arabinose, xylose, glucose, and galactose
    A L Heaton
    Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Phys Chem A 112:10156-67. 2008
    ..contributions of individual structural characteristics as well as the energetic trends in binding among the monosaccharides is developed...
  54. ncbi Spectral signatures and structural motifs in isolated and hydrated monosaccharides: phenyl alpha- and beta-l-fucopyranoside
    Pierre Çarçabal
    Department of Chemistry, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, UK
    Phys Chem Chem Phys 8:129-36. 2006
    ....
  55. ncbi Monosaccharides as internal probes for the determination of the absolute configuration of 2-butanol
    Patrycja Seroka
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 80 952 Gdansk, Poland
    Magn Reson Chem 44:132-8. 2006
    ....
  56. ncbi "Click" grafting of high loading of polymers and monosaccharides on surface of ordered mesoporous silica
    Liang Huang
    Center for Engineered Polymeric Materials, Department of Chemistry, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, New York 10314, USA
    Langmuir 26:2688-93. 2010
    The azide-alkyne cycloaddition "click" reaction was used to covalently bond high loadings of polymers and monosaccharides to the surface of an ordered mesoporous silica...
  57. ncbi The stereochemical dependence of unimolecular dissociation of monosaccharide-glycolaldehyde anions in the gas phase: a basis for assignment of the stereochemistry and anomeric configuration of monosaccharides in oligosaccharides by mass spectrometry via a
    Tammy T Fang
    Department of Cellular and Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    J Am Chem Soc 129:9721-36. 2007
    ..linked to a 2-carbon aglycon derived from the reducing sugar, irrespective of the linkage position between monosaccharides. This enabled the location of the intact sugar to be assigned to the nonreducing side of a glycosidic linkage...
  58. ncbi Application of capillary zone electrophoresis and reversed-phase high-performance liquid chromatography in the biopharmaceutical industry for the quantitative analysis of the monosaccharides released from a highly glycosylated therapeutic protein
    K Racaityte
    Unit Analytics, Solvias AG, CH 4002 Basel, Switzerland
    J Chromatogr A 1079:354-65. 2005
    Two assays for the quantitative determination of the neutral and amino-monosaccharides attached to a therapeutic glycoprotein were developed using capillary zone electrophoresis (CZE) and RP-HPLC...
  59. ncbi Inhibition of Pseudomonas aeruginosa adhesion to fibronectin by PA-IL and monosaccharides: involvement of a lectin-like process
    Julie Rebiere-Huët
    Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules, Universite de Cergy Pontoise, Unité de Formation et de Recherche Sciences et Techniques, Cergy Pontoise, France
    Can J Microbiol 50:303-12. 2004
    ..7%, 100%, and 60% of inhibition, respectively. We have demonstrated here the involvement of a lectin-like process in the interaction of P. aeruginosa NK 125 502 with immobilized fibronectin...
  60. ncbi A new Ralstonia solanacearum high-affinity mannose-binding lectin RS-IIL structurally resembling the Pseudomonas aeruginosa fucose-specific lectin PA-IIL
    Dvora Sudakevitz
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel
    Mol Microbiol 52:691-700. 2004
    ..The binding loop of the cations is fully conserved in RS-IIL and PA-IIL, whereas the preference for mannose versus fucose can be attributed to the change of a three-amino-acid sequence in the 'specificity loop'...
  61. ncbi Effect of neuraminidase on adherence of Pseudomonas aeruginosa to human buccal epithelial cells. Inhibition of adhesion by monosaccharides
    Katarzyna Wolska
    Department of Microbiology, Agricultural Faculty, University Podlasie, 08 110 Siedlce
    Pol J Microbiol 55:43-8. 2006
    ..aeruginosa strains. Monosaccharides inhibition studies showed an inhibition of adhesion of P...
  62. ncbi Synthesis of a potent and selective inhibitor of p90 Rsk
    David J Maloney
    Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA
    Org Lett 7:1097-9. 2005
    ..The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation...
  63. ncbi Chiral resolution of monosaccharides as 1-phenyl-3-methyl-5-pyrazolone derivatives by ligand-exchange CE using borate anion as a central ion of the chiral selector
    Shuji Kodama
    Toyama Institute of Health, Toyama, Japan
    Electrophoresis 27:4730-4. 2006
    Six reducing monosaccharides (mannose, galactose, fucose, glucose, xylose, and arabinose) were derivatized with 1-phenyl-3-methyl-5-pyrazolone (PMP) and chiral resolution of these racemic PMP-monosaccharides was studied by ligand-..
  64. ncbi Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development
    P E Fraser
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 276:6412-9. 2001
    ..spectroscopy, and competitive inhibition ELISAs, we have evaluated the ability of chondroitin sulfate-derived monosaccharides and disaccharides to induce the structural changes in A beta that are associated with GAG interactions...
  65. ncbi Monosaccharides modulate HCV E2 protein-derived peptide biological properties
    Javier E Garcia
    Fundación Instituto de Immunología de Colombia, Carrera 50 26 00, Bogota, Colombia
    Biochem Biophys Res Commun 355:409-18. 2007
    ..N-Glycopeptides derived from this sequence contained monosaccharides in Asn(532)...
  66. ncbi A gram distribution kernel applied to glycan classification and motif extraction
    Tetsuji Kuboyama
    Center for Collaborative Research, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo, 153 8505, Japan
    Genome Inform 17:25-34. 2006
    ..In addition, we extract specific features from various types of glycan data using our trained SVM. The results show that our kernel is more flexible and capable of finding a wider variety of substructures from glycan data...
  67. ncbi "Glyco-peakfinder"--de novo composition analysis of glycoconjugates
    Kai Maass
    Institute of Biochemistry, Faculty of Medicine, University of Giessen, Germany
    Proteomics 7:4435-44. 2007
    ..To provide access to known carbohydrate structures a "composition search" in the open access database GLYCOSCIENCES.de can be performed. The service is available at the URL: www.eurocarbdb.org/applications/ms-tools...
  68. pmc Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases
    Jared C Lewis
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:16550-5. 2009
    ..efficient means to access valuable intermediates, which can be converted to a wide range of substituted monosaccharides and polysaccharides...
  69. ncbi Separation of monosaccharides by hydrophilic interaction chromatography with evaporative light scattering detection
    Goran Karlsson
    Octapharma AB, SE 11275 Stockholm, Sweden
    J Chromatogr A 1092:246-9. 2005
    Hydrophilic interaction liquid chromatography (HILIC) was used to separate monosaccharides that are common in N-linked oligosaccharides in glycoproteins and other compounds...
  70. pmc Anaerobic consumers of monosaccharides in a moderately acidic fen
    Alexandra Hamberger
    Department of Ecological Microbiology, University of Bayreuth, 95445 Bayreuth, Germany
    Appl Environ Microbiol 74:3112-20. 2008
    ....
  71. ncbi Simultaneous determination of monosaccharides in glycoproteins by capillary electrophoresis
    T Soga
    Yokogawa Analytical Systems, Inc, 2 11 13 Nakacho, Musashino shi, Tokyo 180 0006, Japan
    Anal Biochem 261:73-8. 1998
    ..This method was applied to the composition analysis of monosaccharides in glycoprotein...
  72. pmc Thermochemistry of microhydration of sodiated and potassiated monosaccharides
    Henryk Wincel
    Institute of Physical Chemistry, Polish Academy of Sciences, 01 224, Warsaw, Poland
    J Am Soc Mass Spectrom 22:1570-6. 2011
    ..The thermochemical properties ΔH(o)(n), ΔS(o)(n), and ΔG(o)(n) for the hydration of sodiated and potassiated monosaccharides (Ara = arabinose, Xyl = xylose, Rib = ribose, Glc = glucose, and Gal = galactose) have ..
  73. ncbi Concentrations of monosaccharides and their amino and alcohol derivatives in human preovulatory follicular fluid
    Maciej Jozwik
    Department of Gynecology, Medical University of Bialystok, Sklodowskiej 24 A, 15 276 Bialystok, Poland
    Mol Hum Reprod 13:791-6. 2007
    ..These plasma-FF differences may reflect both utilization of these carbohydrates by the cells of the preovulatory ovarian follicle and/or transport characteristics of these cells...
  74. ncbi Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU)
    Jonathan K Watts
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 2K6
    J Org Chem 71:921-5. 2006
    ..The sharp conformational switch attained by replacing the ring heteroatom is attributed to a decrease in relevant steric and stereoelectronic effects...
  75. ncbi Structural basis for the activity of the RSK-specific inhibitor, SL0101
    Jeffrey A Smith
    Center for Cell Signaling, Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Bioorg Med Chem 15:5018-34. 2007
    ..These studies should facilitate the development of a RSK inhibitor, based on the SL0101 pharmacophore, as an anti-cancer chemotherapeutic agent...
  76. ncbi Effects of dietary monosaccharides on sympathetic nervous system activity in adipose tissues of male rats
    James B Young
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago Ward 4 161, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
    Diabetes 53:1271-8. 2004
    ..These studies are consistent with activation of a neural pathway by oral glucose or fructose, leading to SNS activation in IBAT and retroperitoneal fat and enhanced GLUT4 expression...
  77. pmc Automated interpretation of MS/MS spectra of oligosaccharides
    Haixu Tang
    School of Informatics, Indiana University Bloomington, IN, USA
    Bioinformatics 21:i431-9. 2005
    ..internal cleavages provide additional information that is important to reveal the type of linkage between monosaccharides. This information, however, is not incorporated into the current programs for analyzing glycan mass spectra...
  78. ncbi The distinction of underivatized monosaccharides using electrospray ionization ion trap mass spectrometry
    Xingyu Zhu
    Department of Biosciences and Informatics, Keio University, 3 14 1 Hiyoshi, Yokohama 223 8522, Japan
    Rapid Commun Mass Spectrom 21:191-8. 2007
    A convenient method for distinguishing underivatized isomeric monosaccharides has been established using electrospray ionization ion trap mass spectrometry (ESI-ITMS)...
  79. ncbi Oxime-based receptors for mono- and disaccharides
    Monika Mazik
    Institut für Organische Chemie der Technischen Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany
    J Org Chem 72:8319-26. 2007
    ..Molecular modeling calculations, synthesis, and binding studies are described...
  80. ncbi The N-linked oligosaccharides of aminopeptidase N from Manduca sexta: site localization and identification of novel N-glycan structures
    Elaine Stephens
    Department of Chemistry, University of Cambridge, UK
    Eur J Biochem 271:4241-58. 2004
    ..The paucimannosidic N-glycan (Man(3)GlcNAc(2)), commonly found on other insect glycoproteins, is the predominant oligosaccharide found at the remaining N-glycosylation site (Asn609)...
  81. ncbi Versatile acetylation of carbohydrate substrates with bench-top sulfonic acids and application to one-pot syntheses of peracetylated thioglycosides
    Chin Sheng Chao
    Department of Applied Chemistry, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu 300, Taiwan, ROC
    Carbohydr Res 343:957-64. 2008
    ..Simple one-pot two step acetylation-thioglycosidation methods for the expeditious synthesis of p-tolyl per-O-acetyl thioglycosides were also delineated...
  82. ncbi Identification and quantitative determination of carbohydrates in ethanolic extracts of two conifers using 13C NMR spectroscopy
    Emilie Duquesnoy
    Université de Corse, Equipe Chimie et Biomasse, UMR CNRS 6134, Route des Iles Sanguinaires, 20000 Ajaccio, France
    Carbohydr Res 343:893-902. 2008
    ..We determined that carbohydrates represented from 15% to 35% of the crude extracts in which pinitol was the principal constituent accompanied by arabinitol, mannitol, glucose and fructose...
  83. ncbi Hydrogen bonded oligohydrazide foldamers and their recognition for saccharides
    Jun Li Hou
    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Am Chem Soc 126:12386-94. 2004
    ..The hydrazide-based folding structures described here represent novel examples of hydrogen bonding-driven foldamers that act as artificial receptors for selective molecular recognition...
  84. ncbi Conformational effects on glycoside reactivity: study of the high reactive conformer of glucose
    Ciaran McDonnell
    Department of Chemistry, University College Dublin, Ireland
    J Am Chem Soc 126:12374-85. 2004
    ..The finding that (1)C(4) conformers of glucosides are highly reactive species is in accordance with and supports previous results showing that axial OH groups are less electron withdrawing than equatorial OH groups...
  85. ncbi Regiospecific alkaline protease-catalyzed divinyl acyl transesterifications of primary hydroxyl groups of mono- and di-saccharides in pyridine
    Qi Wu
    Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China
    Carbohydr Res 339:2059-67. 2004
    ..The influences of the enzymes, solvents, temperature, and acyl donor chain length on the reaction were studied. Vinyl sugar esters offer a new family of functional water-soluble monomers for preparation of sugar-containing polymers...
  86. ncbi Indium-promoted Barbier-type allylations in aqueous media: a convenient approach to 4-C-branched monosaccharides and (1-->4)-C-disaccharides
    Eric Levoirier
    Laboratoire de Chimie Organique Multifonctionnelle, associé au CNRS UMR 8614, Institut de Chimie Moléculaire et des Matériaux d Orsay ICMMO, Universite Paris Sud, Bat 420, F 91405 Orsay, France
    Carbohydr Res 339:2737-47. 2004
    ..The intermediate unsaturated monosaccharides were shown to rearrange in acidic media to give 4-C-acetyl-5-C-alkyl pyranose compounds...
  87. ncbi Primary structure and configuration of tea polysaccharide
    Peng Zhou
    Key Laboratory of Food Science of Ministry of Education, Nanchang University, Nanchang 330047, China
    Sci China C Life Sci 47:416-24. 2004
    ..The results indicate that TGC consists of 6 monosaccharides: Rha, Ara, Xyl, Glu, Man and Gal...
  88. pmc Characterization of N-linked oligosaccharides in chorion peroxidase of Aedes aegypti mosquito
    Junsuo S Li
    Department of Pathobiology, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Protein Sci 14:2370-86. 2005
    ..Comparison of CPO activity and Stokes radius between native and deglycosylated CPO suggests that the N-linked oligosaccharides influence the enzyme activity by stabilizing its folded state...
  89. ncbi Conformational domino effect in saccharides: a prediction from alkyl beta-(1-->6)-diglucopyranosides
    Alfredo Roën
    Instituto Universitario de Bio Organica Antonio Gonzalez, Department de Quimica Organica, Universidad de La Laguna, Tenerife, Spain
    J Org Chem 73:3351-63. 2008
    ..The population of the gauche- gauche (gg) rotamer decreased, and that of gt increased as the Taft's steric parameters of the remote aglycon increased, independently of the disaccharide series and of the solvent...
  90. ncbi Agrobacterium rubi(T) DSM 6772 produces a lipophilic polysaccharide capsule whose degree of acetylation is growth modulated
    Cristina De Castro
    Department of Organic Chemistry and Biochemistry, University of Naples, Complesso Universitario Monte Sant Angelo, Via Cintia 4, 80126 Napoli, Italy
    Biomacromolecules 8:1047-51. 2007
    ..This decoration is not stoichiometric and it depends on the growth stadium of the bacterium, leading to an almost regular acetylation pattern only at the stationary phase, where all the potential positions are substituted...
  91. ncbi Synthesis of benzylidenated hexopyranosides in ionic liquids
    Jianguo Zhang
    Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Carbohydr Res 340:2812-5. 2005
    The synthesis of 4,6-O-benzylidenated monosaccharides and disaccharides has been studied using ionic liquids as a unique solvent alternative...
  92. ncbi The fine structure of Caenorhabditis elegans N-glycans
    John F Cipollo
    Department of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University, 715 Albany Street, Boston, MA 02118 2526, USA
    J Biol Chem 277:49143-57. 2002
    ..Therefore, elucidation of its N-glycome, as shown in this report, may place it among the useful systems used to investigate human disorders of glycoconjugate synthesis such as the congenital disorders of glycosylation syndromes...
  93. ncbi NMR and MALDI-TOFMS analysis of a heteroglycan isolated from hot water extract of edible mushroom, Volvariella bombycina
    Debsankar Das
    Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721102, West Bengal, India
    Carbohydr Res 343:2258-65. 2008
    ....
  94. ncbi A novel beta-galactosidase capable of glycosyl transfer from Enterobacter agglomerans B1
    Lili Lu
    State Key Lab of Microbial Technology, Shandong University, Jinan 250100, China
    Biochem Biophys Res Commun 356:78-84. 2007
    ..It revealed an ORF of 3090 nucleotides encoding a 1029 amino-acid protein, which had been expressed in Escherichia coli. Transferase activities in both recombinant and natural enzymes were similar...
  95. ncbi A global representation of the carbohydrate structures: a tool for the analysis of glycan
    Kosuke Hashimoto
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Genome Inform 16:214-22. 2005
    ..These resources are available at http://www.genome.jp/kegg/glycan/...
  96. ncbi Preparation of partially benzylated mono-, di-, and trisaccharides by selective cleavage of the beta-fructofuranosidic linkage in fully benzylated sucrose and sucrose-related oligosaccharides under acidic conditions
    Takashi Yamanoi
    The Noguchi Institute, Tokyo, Japan
    Carbohydr Res 343:1366-72. 2008
    ....
  97. ncbi Studies directed to understanding the structure of chitosan-metal complexes: investigations of mono- and disaccharide models with platinum(II) group metals
    Sine A Johannesen
    Department of Chemistry and Interdisciplinary Nanoscience Center, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark
    Inorg Chem 46:4326-35. 2007
    X-ray and NMR experiments were performed with simple chitosan models based on glucosamine monosaccharides and disaccharides to understand the binding properties and structures of the complexes formed between this polysaccharide and ..
  98. ncbi A synthetic lectin analog for biomimetic disaccharide recognition
    Yann Ferrand
    School of Chemistry, University of Bristol, Cantock s Close, Bristol BS8 1TS, UK
    Science 318:619-22. 2007
    ..Selectivity for the target substrates was exceptional; minor changes to disaccharide structure (for instance, cellobiose to lactose) caused almost complete suppression of complex formation...
  99. ncbi Oligosaccharide analyses of glycopeptides of horseradish peroxidase by thermal-assisted partial acid hydrolysis and mass spectrometry
    Bao Shiang Lee
    Protein Research Laboratory, Research Resources Center, 835 S Wolcott Avenue, University of Illinois, Chicago, IL 60612, USA
    Carbohydr Res 340:1859-65. 2005
    ..However, the glycosylation site of the 2612Da peptide at Asn286 is partially occupied. This method is particularly useful in identifying glycopeptides and obtaining monosaccharide compositions of glycopeptides...
  100. ncbi Highly effective receptors showing di- vs. monosaccharide preference
    Monika Mazik
    Institut für Organische Chemie der Technischen Universität Braunschweig, Hagenring 30, 38106, Braunschweig, Germany
    Org Biomol Chem 6:1558-68. 2008
    ..Both hydrogen-bonding and interactions of the sugar CH's with the phenyl rings of the receptor contribute to the stabilisation of the receptor-sugar complexes. Molecular modeling calculations, synthesis and binding studies are described...
  101. ncbi MUC5B glycosylation in human saliva reflects blood group and secretor status
    Kristina A Thomsson
    Department of Medical Biochemistry, Goteborg University, Box 440, 405 30 Goteborg, Sweden
    Glycobiology 15:791-804. 2005
    ..Our results highlight that salivary MUC5B consists of glycoforms with distinct glycosylation that vary extensively between individuals and that some of this variation is owing to blood group and secretor status...

Research Grants63

  1. Investigation on Oligosaccharides as Antimicrobial and Prebiotics
    Peng George Wang; Fiscal Year: 2013
    ..These building blocks are themselves biosynthesized and recycled from individual monosaccharides through a series of biosynthetic enzymes...
  2. Photocrosslinking characterization of heat-labile toxin glycoreceptors
    Amberlyn M Wands; Fiscal Year: 2013
    ..be used to covalently capture cell-surface binding partners by inserting a crosslinker at specific types of monosaccharides within glycan structures and (2) to use this technology to answer the ongoing problem of which glycoprotein ..
  3. Small Cell-Penetrating Glyco-Decoys Sidetrack Selectin Ligand Biosynthesis
    Khushi L Matta; Fiscal Year: 2013
    ..In another approach, we focused on synthesis of modified analogs of monosaccharides such as 4-fluoro-GlcNAc acetates and 4-fluoro-GalNAc acetates as cell-penetrating metabolic inhibitors of the ..
  4. Impact of glycosylation on PsrP function
    Anel Lizcano; Fiscal Year: 2013
    ..We will address this by focusing on two aims: 1) To determine the glycosylation patterns and quantity of monosaccharides on wild type PsrP and individual glycosyltransferase deletion mutants correlation with effects on adhesion in ..
  5. Biofilm Development by Vibrio cholerae
    Paula I Watnick; Fiscal Year: 2010
    ..These are (i) monosaccharides are strong inducers of biofilm development and transcription of genes encoding monosaccharide transporters is ..
  6. Taste receptor signaling in beta cells and role in postprandial insulin secretion
    George Kyriazis; Fiscal Year: 2012
    ..is an important sensory system that modulates insulin secretion in response to ingested nutrients, such as monosaccharides and amino acids...
  7. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
    ..member library of 3'-N-glycosyl derivatives of AMB methyl ester by the Amidori rearrangement using novel monosaccharides;3) to screen the resulting neoglycosides and 3'-N-sugar conjugates for antifungal activity in vitro (MIC ..
  8. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng Wang; Fiscal Year: 2009
    ..We will establish an in vitro reaction system based on the chemical synthesis of lipid pyrophosphate linked monosaccharides and enzymatic assembly of the corresponding CPS repeating unit...
  9. NUTRITIONAL EFFECTS OF SUGARS ON LIVER LIPIDS
    CHARLES SPARKS; Fiscal Year: 1990
    b>Monosaccharides and disaccharides are known to result in hyperlipoproteinemia in rabbit nutritional studies...
  10. Photogenerated Carbohydrate Microarrays
    Mingdi Yan; Fiscal Year: 2012
    ..These array chemistries will accommodate a wide range of carbohydrates from simple monosaccharides to more complex glycoconjugates...
  11. Fluorous Solution-Phase Synthesis of Peptides and Oligosaccharides
    Nicola Pohl; Fiscal Year: 2009
    ..4) Demonstration of a mixed peptide/carbohydrate microarray. Fluorous-tagged peptides and monosaccharides will be printed on a fluorous glass plate, and binding to the fluorescein isothiocyanate- labeled jack bean ..
  12. Stereoselective Rearrangements for the Synthesis of Bioactive Small Molecules
    UTTAM KRISHAN TAMBAR; Fiscal Year: 2013
    ..1: Stereoselective Synthesis of Amino alcohols and Selectively Protected Monosaccharides B...
  13. Studies of naturally occurring structurally modified carbohydrates
    Xi Chen; Fiscal Year: 2010
    ..Furthermore, modifications of sialic acid monosaccharides, such as sulfation, phosphorylation, methylation, acetylation, and lactylation, lead to the observation of ..
  14. CARBOHYDRATE FRACTIONATION FACILITY
    Pamela Stanley; Fiscal Year: 1990
    ..Facility that uses the latest HPLC techniques for rapidly separating and quantitating complex mixtures of monosaccharides, oligosaccharides and glycopeptides with maximal resolution and sensitivity...
  15. P SELECTIN LIGAND ON HUMAN T CELL
    Kevin Moore; Fiscal Year: 1999
    ..of the oligosaccharides derived from the ligand isolated from T cell clones metabolically labeled with [3H]monosaccharides. These studies should provide new insights into the molecular mechanisms for P-selectin interaction with ..
  16. PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATION
    Jiri Mestecky; Fiscal Year: 2006
    ..aberrancies of Ig molecules in PD patients by reactivity with lectins highly specific for component monosaccharides and by direct carbohydrate analyses...
  17. Oligosaccharides Against Enteric Infections
    Ryan Woodyer; Fiscal Year: 2010
    ..analogs in sufficient quantities for preclinical and clinical testing is using glycosyltransferases in vitro with simple starting materials such as monosaccharides or readily available polysaccharides and nucleotide activated sugars.
  18. Genetic System to Study Virulence in Bacteroides
    Michael Malamy; Fiscal Year: 2003
    ..capable of converting the complex Lewis antigen found on the surface of many human cells to individual monosaccharides. We will continue to define the operon for NANA utilization, the NanL1 operon...
  19. Mass Spectrometry Method for Carbohydrate Structure
    HERBERT HILL; Fiscal Year: 2006
    ..The critical steps in this plan are the production of monosaccharides by fragmentation in the ion trap and the separation of monosaccharides by IMS...
  20. SYNTHETIC MONOSACCHARIDES ADJUVANTS FOR HUMAN VACCINES
    David Johnson; Fiscal Year: 2000
    ..abstract_text> ..
  21. IMMUNOCHEMISTRY OF STREPTOCOCCAL MEMBRANE PROTEINS
    Ivo van de Rijn; Fiscal Year: 1990
    ..phospholipid requirements, substrate kinetics, size of product, role of primer, and location of addition of monosaccharides (reducing or nonreducing end)...
  22. ENZYME CATALYZED SYNTHESIS OF MONOSACCHARIDES
    George Whitesides; Fiscal Year: 2000
    ..aldolase, fuculose-1-phosphate aldolase, rhamnulose-1-phosphate aldolase and transketolase -- to make monosaccharides. . Synthesize the nucleoside phosphate sugars required for Leloir-pathway syntheses. ...
  23. Regulation of Intestinal Nutrient Transporters
    Martin Martin; Fiscal Year: 2002
    ..The sodium/glucose cotransporter (SGLT1) is expressed primarily by small intestinal cells and transports the monosaccharides, glucose and galactose, across the apical membrane...
  24. In Vitro Glycorandomization of Natural Products
    JON SCOTT THORSON; Fiscal Year: 2013
    ..chemoenzymatic glycorandomization (a one pot, three enzyme strategy capable of activating and attaching free monosaccharides to complex natural product scaffolds) and also provided fundamental information regarding two critical, but ..
  25. Cell based HTS for Rescue of Mutant Lysosomal Enzymes
    Don Mahuran; Fiscal Year: 2006
    ..disease the affected enzymes, Hexosaminidase and Glucocerebrosidase, are unable to cleave the terminal monosaccharides from gangliosides leading to their accumulation in the lysosome...
  26. PHLORIZIN INHIBITION OF SUGAR TRANSPORT
    DONALD DIEDRICH; Fiscal Year: 1980
    The nature of the cell membrane receptor to which glucose and other monosaccharides are bound prior to and during their penetration into the cell is being studied...
  27. CARBOHYDRATE DETERMINANTS IN MAMMALIAN FERTILIZATION
    RICHARD CARDULLO; Fiscal Year: 1999
    ..Using this new assay, defined monosaccharides, simple oligosaccharides, and complex oligosaccharides will be compared to identify potential carbohydrate ..
  28. Novel Vaccine Targeting the Sugar Coat of HIV-1
    Lai Xi Wang; Fiscal Year: 2004
    ..Man9GlcNAc2 will be chosen as the high-mannose oligosaccharide moiety and monosaccharides will be used as the scaffold (template) to present these oligosaccharides to form a clustering structure...
  29. Neutron Diffraction and MD Studies of the Studies of the Structure of Aqueous Sol
    John W Brady; Fiscal Year: 2010
    ..In addition to a systematic analysis of the biologically-important simple monosaccharides and their analogs, the technique will be extended to studies of amino acids, nucleotides, and other small ..
  30. SUPPRESSING HIV INFECTION BY SUBSTITUTED MONOSACCHARIDES
    Paul Gordon; Fiscal Year: 1990
    ..Anti-HIV effects obtained will be compared with those of azidothymidine (AZT) and dextran sulfate...
  31. GLYCAN SEQUENCING AT THE FEMTOMOLE LEVEL (SFC-NCI-MS)
    Vernon Reinhold; Fiscal Year: 1993
    ..comparable femtomole sensitivity (SFC-NCI-MS) with PFBAB-labeled, partially methylated and acetylated monosaccharides in support of monomer identification studies; and, (d) initiating high and low energy CID studies with the ..
  32. ENZYMES IN ORGANIC SYNTHESIS
    Chi Huey Wong; Fiscal Year: 1999
    ..Develop catalytic asymmetric aldol condensations based on aldolases for the synthesis of monosaccharides, carbocycles and analogs. 2...
  33. MOLECULAR MECHANISMS OF INSULIN ACTION
    ALAN SALTIEL; Fiscal Year: 1991
    ..Component monosaccharides will analyzed by mass spectroscopy...
  34. High-throughput annotation of glycan mass spectra
    David Goldberg; Fiscal Year: 2009
    ..of expert knowledge of synthetic pathways, in order to limit the huge number of theoretical combinations of monosaccharides to the much smaller number that are actually synthesized in nature...
  35. Synthesis and Glycosylation of an Angelmicin B Acceptor
    TROY RYBA; Fiscal Year: 2007
    ..When both the glycosyl acceptor and the enantiopure monosaccharides are in hand, methodology for alpha- and beta- stereoselective glycosylations of hindered substrates will be ..
  36. EUKARYOTIC HYALURONAN SYNTHASES
    PAUL DEANGELIS; Fiscal Year: 2001
    ..The essential residues identified in aim 3 will also be confirmed by mutagenesis studies. The enzymological and structural information may allow the generation of a working model describing the catalytic mechanism of these enzymes. ..
  37. Basis of Post-Fontan Protein Losing Enteropathy
    Hudson Freeze; Fiscal Year: 2006
    ..The results could provide a fundamental understanding of how PLE develops, identify Fontan patients genetically at risk for developing PLE, and provide insights to new therapeutics for this enigmatic rare disease. ..
  38. MOLECULAR BASIS OF ENTEROCYTE REGULATION DURING ONTOGENY
    Martin Martin; Fiscal Year: 2002
    ..Analysis of the FcRn and pIgR genes offers a unique model that may lead to a better understanding of the molecular mechanism of intestinal ontogeny, and specifically the intrinsic clock which controls its regulation. ..
  39. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2002
    ..Efforts have been made to attract established investigators from related disciplines who can complement the expertise of the LAM investigators. ..
  40. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
    ..These studies will elucidate the role of SP-A in the innate immune defense of the lung, and may assist in the design of optimal antimicrobial strategies. ..
  41. Kynurenic Acid Synthesis in Mouse Brain
    Jianyong Li; Fiscal Year: 2010
    ..The research described in this proposal investigates physiology and biochemistry of enzymes responsible for the production of brain KYNA using mice as model species. ..
  42. Novel Approaches to Mend Deficient Glycosylation
    Hudson Freeze; Fiscal Year: 2005
    ....
  43. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  44. MANNOSE IN MAMMALIAN GLYCOPROTEIN SYNTHESIS
    Hudson Freeze; Fiscal Year: 2001
    ..In some cases, mannose may be a therapeutic dietary supplement. A mannose supplementation trial for CDGS patients is now underway. ..
  45. Amine N-Oxygenation by FMO3 and FMO4
    John Cashman; Fiscal Year: 2005
    ..Such fundamental information will be useful in the development of safer drugs, the prevention of adverse drug reactions and the protection of humans from disease. ..
  46. Lymphangioleimyomatosis Research Conference
    Francis McCormack; Fiscal Year: 2004
    ..abstract_text> ..
  47. Biochemistry of Chorion Hardening in Mosquitoes
    Jianyong Li; Fiscal Year: 2005
    ....
  48. DEVELOPMENT GLYCOBIOLOGY OF CAENORHABDITIS ELEGANS
    Richard Cummings; Fiscal Year: 2003
    ..Since C. elegans and vertebrates express many similar glycosyltransferases, these studies may also provide important insights into glycan function in vertebrate development, differentiation and acquisition of the malignant phenotype. ..
  49. 'Immunity of Schistosome Glycoconjugates'
    Richard Cummings; Fiscal Year: 2003
    ....
  50. NUCLEOTIDE DONORS AFFECTING GLYCOSYLATION PATHWAYS
    Ajit Varki; Fiscal Year: 2003
    ....
  51. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2006
    ..The contributions of beta- amino acids produced by lysine 2,3-aminomutase and arginine 2,3-aminomutase to the functions of antibiotics are not known. The beta-aminoacids may become significant in drug development. ..
  52. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. Human Glycosylation Disorders 2003
    Hudson Freeze; Fiscal Year: 2004
    ..Since this meeting immediately precedes the annual meeting of the Society for Glycobiology, it will increase the chances of recruiting glycobiologists to explore the various types of human glycosylation disorders. ..
  54. Inhibitor of FtsZ Polymerization in M. tuberculosis
    Robert Reynolds; Fiscal Year: 2004
    ..Data from the biological screening and the EM structural studies will feed back into compound design in an interactive, iterative drug design cycle that critically focuses on antibacterial potency and selectivity. ..
  55. TEACHING BIOLOGY THROUGH IMMUNOLOGY FELLOWSHIPS
    Arthur Tzianabos; Fiscal Year: 2007
    ..Thus, we will also survey each teacher and school district previously in the program in order to determine the effect of the program on science education and student career choices. [unreadable] [unreadable]..
  56. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  57. Glucose-Sensing and Intestinal Feedback Inhibition
    Helen Raybould; Fiscal Year: 2007
    ..A greater understanding of these sensory mechanisms will help in understanding the pathophysiology of these diseases. ..
  58. Cell Fate Determination of the Intestine and Chronic Diarrhea in Children
    Martin Martin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..The results will provide important insights into the roles of the surfactant proteins in preventing oxidative lung disease and may be useful for the design of novel recombinant proteins and peptides of therapeutic value. ..
  60. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
  61. C-C & C-N Bond Formation in Unusual Sugar Biosynthesis
    Hung wen Liu; Fiscal Year: 2007
    ..Overall, our results are expected to make a significant contribution to the fundamentals of enzyme chemistry and possibly impact pharmaceutical biotechnology. ..
  62. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  63. FASEB Summer Conference on Microbial Polysaccharides
    Arthur Tzianabos; Fiscal Year: 2004
    ..This meeting will provide a unique environment for scientific exchange between a diverse group of investigators in the area of microbial polysaccharides. ..