clindamycin

Summary

Summary: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.

Top Publications

  1. pmc Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
    Charlie G Buffie
    Infectious Diseases Service, Department of Medicine, Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 80:62-73. 2012
  2. ncbi A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503
    Corinna Kehrenberg
    Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, Höltystrasse 10, 31535 Neustadt Mariensee, Germany
    Mol Microbiol 57:1064-73. 2005
  3. ncbi Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection
    Jane Freeman
    Department of Microbiology, University of Leeds and The General Infirmary, Old Medical School, Leeds, LS1 3EX, UK
    J Antimicrob Chemother 56:717-25. 2005
  4. pmc Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites
    Neekesh V Dharia
    Department of Cell Biology, ICND 202, The Scripps Research Institute, La Jolla, California 92037, USA
    Genome Res 20:1534-44. 2010
  5. pmc Efficacy of oral metronidazole with vaginal clindamycin or vaginal probiotic for bacterial vaginosis: randomised placebo-controlled double-blind trial
    Catriona S Bradshaw
    Melbourne School of Population Health, University of Melbourne, Melbourne, Australia
    PLoS ONE 7:e34540. 2012
  6. pmc Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis
    Charles O Obonyo
    Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
    Malar J 11:2. 2012
  7. pmc Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vi
    Kerry L LaPlante
    Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 52:2156-62. 2008
  8. ncbi Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis
    Masoud Soheilian
    Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran
    Ophthalmology 118:134-41. 2011
  9. pmc Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses
    Per Goran Larsson
    Department of Obstetrics and Gynaecology Kärnsjukhuset, Skaraborg hospital and University of Skövde, Sweden
    BMC Infect Dis 11:223. 2011
  10. pmc Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria
    Sunny Oyakhirome
    Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, Tubingen, Germany
    Antimicrob Agents Chemother 51:1869-71. 2007

Detail Information

Publications295 found, 100 shown here

  1. pmc Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
    Charlie G Buffie
    Infectious Diseases Service, Department of Medicine, Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 80:62-73. 2012
    ..b>Clindamycin predisposes patients to C. difficile colitis...
  2. ncbi A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503
    Corinna Kehrenberg
    Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, Höltystrasse 10, 31535 Neustadt Mariensee, Germany
    Mol Microbiol 57:1064-73. 2005
    The gene product of cfr from Staphylococcus sciuri confers resistance to chloramphenicol, florfenicol and clindamycin in Staphylococcus spp. and Escherichia coli...
  3. ncbi Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection
    Jane Freeman
    Department of Microbiology, University of Leeds and The General Infirmary, Old Medical School, Leeds, LS1 3EX, UK
    J Antimicrob Chemother 56:717-25. 2005
    ..We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.
  4. pmc Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites
    Neekesh V Dharia
    Department of Cell Biology, ICND 202, The Scripps Research Institute, La Jolla, California 92037, USA
    Genome Res 20:1534-44. 2010
    ..isolates we discovered point mutations in the apicoplast genome that are close to known mutations that confer clindamycin resistance in other species, but which were hitherto unknown in malaria parasites...
  5. pmc Efficacy of oral metronidazole with vaginal clindamycin or vaginal probiotic for bacterial vaginosis: randomised placebo-controlled double-blind trial
    Catriona S Bradshaw
    Melbourne School of Population Health, University of Melbourne, Melbourne, Australia
    PLoS ONE 7:e34540. 2012
    To determine if oral metronidazole (MTZ-400 mg bid) with 2% vaginal clindamycin-cream (Clind) or a Lactobacillus acidophilus vaginal-probiotic containing oestriol (Prob) reduces 6-month bacterial vaginosis (BV) recurrence.
  6. pmc Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis
    Charles O Obonyo
    Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
    Malar J 11:2. 2012
    ..b>Clindamycin plus quinine is an alternative non-artemisinin-based combination recommended by World Health Organization...
  7. pmc Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vi
    Kerry L LaPlante
    Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 52:2156-62. 2008
    ..Staphylococcus aureus (CA-MRSA) and about the ability of these strains to develop inducible resistance to clindamycin during therapy...
  8. ncbi Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis
    Masoud Soheilian
    Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran
    Ophthalmology 118:134-41. 2011
    To compare the efficacy of intravitreal injection of clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis.
  9. pmc Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses
    Per Goran Larsson
    Department of Obstetrics and Gynaecology Kärnsjukhuset, Skaraborg hospital and University of Skövde, Sweden
    BMC Infect Dis 11:223. 2011
    ....
  10. pmc Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria
    Sunny Oyakhirome
    Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, Tubingen, Germany
    Antimicrob Agents Chemother 51:1869-71. 2007
    Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine...
  11. ncbi Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes
    Sonja Lofmark
    Department of Laboratory Medicine, Karolinska Institute, SE 141 86 Stockholm, Sweden
    J Antimicrob Chemother 58:1160-7. 2006
    The aim was to study the long-term consequences of 1 week clindamycin administration regarding selection and persistence of resistance, resistance determinants and diversity of the Bacteroides spp. in the intestinal microflora.
  12. ncbi Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial
    Michael Ramharter
    Albert Schweitzer Hospital, Lambarene, Gabon, Germany
    Clin Infect Dis 40:1777-84. 2005
    ..We tested the potential value of artemisinin-based combination therapy with a short elimination half-life for the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa...
  13. ncbi Antimicrobial resistance associated with the treatment of bacterial vaginosis
    Richard H Beigi
    MetroHealth Medical Center and Dept of Obstetrics and Gynecology, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Am J Obstet Gynecol 191:1124-9. 2004
    ..This study was undertaken to evaluate antimicrobial susceptibility of vaginal anaerobic bacteria before and after treatment of bacterial vaginosis...
  14. pmc Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system
    Luisa Cochella
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:3786-91. 2004
    ..This mutant was highly resistant to clindamycin in in vitro translation reactions and yet was not viable in Escherichia coli...
  15. ncbi Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model
    Simon D Baines
    Department of Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 62:1078-85. 2008
    ..To compare the efficacy of oritavancin and vancomycin in the treatment of Clostridium difficile infection (CDI) using an in vitro human gut model...
  16. ncbi Prevention of fatal Clostridium difficile-associated disease during continuous administration of clindamycin in hamsters
    Michelle M Merrigan
    Infectious Disease Section, Department of Medicine, Veterans Affairs Chicago Health Care System, Lakeside Division, Chicago, Illinois, USA
    J Infect Dis 188:1922-7. 2003
    ..difficile after administration of clindamycin (Cm). To prevent CDAD during treatment with antibiotics, we gave a Cm-resistant nontoxigenic C...
  17. ncbi Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals
    S Johnson
    Department of Medicine, Veterans Affairs Chicago Health Care System, Lakeside Division, and Northwestern University Medical School, IL 60611, USA
    N Engl J Med 341:1645-51. 1999
    ..Since frequent use of clindamycin was associated with the outbreak in one of the hospitals, we examined the resistance genes of the epidemic-..
  18. ncbi Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem
    Dale N Gerding
    Clin Infect Dis 38:646-8. 2004
  19. ncbi Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro
    A R Shahverdi
    Dept of Pharmaceutical Biotechnology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran Univ of Medical Sciences, 14174 Tehran, Iran
    J Food Sci 72:S055-8. 2007
    Therapy with antimicrobial drugs, such as clindamycin, that perturb the intestinal flora but fail to inhibit growth of other microorganisms can permit the proliferation of Clostridium difficile and the elaboration of exotoxin...
  20. ncbi Clindamycin-resistance in methicillin-resistant Staphylococcus aureus isolated from animals
    M Rich
    Microbiology Department, IDEXX Laboratories, Sandbeck Way, Wetherby, West Yorkshire LS22 7DN, UK
    Vet Microbiol 111:237-40. 2005
    b>Clindamycin is widely used in veterinary medicine to treat a variety of bacterial infections. Resistance to clindamycin amongst staphylococci may be due to modification of the ribosomal target site...
  21. ncbi Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium
    Paul A Sloan
    University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Anesth Analg 94:123-4, table of contents. 2002
    ..report a prolonged neuromuscular block with the nondepolarizing muscle relaxant rapacuronium in the presence of clindamycin. Even when using "short-acting" muscle relaxants, the anesthesiologist must routinely monitor the neuromuscular ..
  22. ncbi Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin
    Lijuan Wang
    Key Laboratory of Major Disease in Children and National Key Discipline of Pediatrics, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children s Hospital, Capital Medical University, Beijing, PR China
    J Med Microbiol 61:1240-7. 2012
    ..CA) meticillin-resistant Staphylococcus aureus (MRSA) to identify the genes responsible for clindamycin and mupirocin resistance in S. aureus isolates from paediatric hospitals in mainland China. A total of 435 S...
  23. ncbi High rates of erythromycin and clindamycin resistance among OBGYN isolates of group B Streptococcus
    Linda P DiPersio
    Falor Division of Surgical Research, Summa Health System, Akron, OH 44304, USA
    Diagn Microbiol Infect Dis 54:79-82. 2006
    ..period from vaginal/rectal specimens demonstrated a very high resistance rate for both erythromycin (54%) and clindamycin (33%). Methylase genes erm(B) and erm(TR) and efflux genes mef(E) and mef(A) were detected...
  24. pmc Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis
    Ronald F Lamont
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 205:177-90. 2011
    The purpose of this study was to determine whether the administration of clindamycin to women with abnormal vaginal flora at <22 weeks of gestation reduces the risk of preterm birth and late miscarriage...
  25. pmc Comparative efficacies of amoxicillin, clindamycin, and moxifloxacin in prevention of bacteremia following dental extractions
    P Diz Dios
    Department of Special Needs, School of Medicine and Dentistry, Santiago de Compostela University, Santiago de Compostela 15872, Spain
    Antimicrob Agents Chemother 50:2996-3002. 2006
    We evaluated the efficacies of oral prophylactic treatment with amoxicillin (AMX), clindamycin (CLI), and moxifloxacin (MXF) in the prevention of bacteremia following dental extractions (BDE)...
  26. pmc Detection of Treponema pallidum subsp. pallidum from skin lesions, serum, and cerebrospinal fluid in an infant with congenital syphilis after clindamycin treatment of the mother during pregnancy
    Vladana Woznicová
    Department of Medical Microbiology, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic
    J Clin Microbiol 45:659-61. 2007
    We report here a case of congenital syphilis in a newborn after clindamycin treatment in pregnancy...
  27. ncbi Macrolides and clindamycin suppress the release of Shiga-like toxins from Escherichia coli O157:H7 in vitro
    J Murakami
    The Second Department of Internal Medicine, Oita Medical University, 1 1, Hasama, 879 5593, Oita, Japan
    Int J Antimicrob Agents 15:103-9. 2000
    ..agents fosfomycin (FOS), cefdinir (CDIN), levofloxacin (LEVX), rokitamycin (ROK), roxithromycin (ROX), and clindamycin (CLI) on the release of Shiga-like toxins (SLTs) by enterohaemorrhagic Escherichia coli (EHEC)...
  28. ncbi Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro
    Dominik Burkhardt
    Department of Parasitology, Institute of Tropical Medicine, University of Tubingen, Germany
    Int J Parasitol 37:777-85. 2007
    b>Clindamycin is safe and effective for the treatment of Plasmodium falciparum malaria, but its use as monotherapy is limited by unacceptably slow initial clinical response rates...
  29. pmc Clindamycin as an antimalarial drug: review of clinical trials
    Bertrand Lell
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Antimicrob Agents Chemother 46:2315-20. 2002
  30. ncbi Inducible clindamycin resistance among clinical isolates of Staphylococci
    A M Ciraj
    Department of Microbiology, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka 576 104, India
    Indian J Pathol Microbiol 52:49-51. 2009
    Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics...
  31. ncbi Intravaginal clindamycin to reduce preterm birth in women with abnormal genital tract flora
    Ronald F Lamont
    Department of Obstetrics and Gynaecology, Northwick Park and St Mark s Hospital, Watford Road, Harrow, Middlesex, London HA1 3UJ, United Kingdom
    Obstet Gynecol 101:516-22. 2003
    To assess the ability of clindamycin vaginal cream to reduce the incidence of preterm birth in women with abnormal genital tract flora in the second trimester of pregnancy.
  32. ncbi Inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples
    V Deotale
    Department of Microbiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram Dist Wardha, M S 442 102, India
    Indian J Med Microbiol 28:124-6. 2010
    b>Clindamycin is commonly used in the treatment of erythromycin resistant Staphylococcus aureus causing skin and soft tissue infections...
  33. ncbi Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris
    J J Leyden
    Department of Dermatology, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Am J Clin Dermatol 2:33-9. 2001
    BACKGROUND: Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris...
  34. ncbi Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne
    Elizabeth M Seidler
    Clinical Unit for Research Trials in Skin, Massachusetts General Hospital, Boston, Massachusetts 02139, USA
    J Am Acad Dermatol 63:52-62. 2010
    Comparative efficacy of the multiple treatments containing benzoyl peroxide (BPO) and clindamycin (CL) is not established.
  35. pmc Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study
    Per Goran Larsson
    Department of Obstetrics and Gynaecology, Karnsjukhuset, SE 541 85 Skövde, Sweden
    BMC Womens Health 8:3. 2008
    ..was to investigate if supplementary lactobacilli treatment could improve the initial cure rate after vaginal clindamycin therapy, and secondly, if lactobacilli as repeated adjunct treatment during 3 menstrual cycles could lengthen ..
  36. pmc Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in Staphylococcus aureus
    S Herbert
    Program in Molecular Pathogenesis, Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 69:2996-3003. 2001
    ..In this report, we show that subinhibitory clindamycin (SBCL) eliminates production of nearly all exoproteins by Staphylococcus aureus but has virtually no effect on ..
  37. ncbi An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii
    Manel Camps
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305 5124, USA
    Mol Microbiol 43:1309-18. 2002
    Toxoplasma gondii is a protozoan sensitive to several inhibitors of prokaryotic translation (e.g. clindamycin, macrolides and tetracyclines)...
  38. pmc Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae
    Annie Canu
    UFR des Sciences Pharmaceutiques, Caen, France
    Antimicrob Agents Chemother 46:125-31. 2002
    ..In six remaining mutants, no mutations in L22, L4, or 23S rRNA could be detected...
  39. ncbi Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations
    Soo Il Lee
    Department of Anesthesiology and Pain Medicine, Dong A University Medical Center and Medicine College, 1, 3 Ka, Dongdaeshin Dong, Seo Gu, Busan, 602 715, Korea
    J Anesth 22:385-90. 2008
    ..and calcium may enhance the use-dependent ion channel block of the nicotinic acetylcholine receptor caused by clindamycin. The purpose of this study was to determine whether calcium and neostigmine antagonize the neuromuscular ..
  40. pmc In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin
    Jochen Wiesner
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Giessen, Germany
    Antimicrob Agents Chemother 46:2889-94. 2002
    ..Synergy was observed between fosmidomycin and the lincosamides, lincomycin and clindamycin. The efficacy of a combination of fosmidomycin and clindamycin was subsequently demonstrated in the Plasmodium ..
  41. ncbi Effect of sub-MIC concentrations of metronidazole, vancomycin, clindamycin and linezolid on toxin gene transcription and production in Clostridium difficile
    Michael Gerber
    Institute of Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstrasse 24, 04103 Leipzig, Germany
    J Med Microbiol 57:776-83. 2008
    ..difficile-associated diarrhoea (CDAD). The impact of metronidazole (MTR), vancomycin (VAN), clindamycin (CLI) and linezolid (LZD) on growth, toxin gene transcription and toxin production in C...
  42. pmc In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?
    Giuseppe Togni
    Unilabs SA, Laboratoire Central de Suisse Romande, Ch des Perrières 2, C P 100, CH 1296 Coppet, Switzerland
    Antimicrob Agents Chemother 55:2490-2. 2011
    ..vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G...
  43. ncbi Lincomycin, clindamycin and their applications
    J Spizek
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Appl Microbiol Biotechnol 64:455-64. 2004
    Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria...
  44. ncbi In-vitro activities of tetracyclines, macrolides, fluoroquinolones and clindamycin against Mycoplasma hominis and Ureaplasma ssp. isolated in Germany over 20 years
    R Krausse
    Institute for Infection Medicine, University Medical Center Schleswig Holstein, Christian Albrecht University of Kiel, Germany
    Clin Microbiol Infect 16:1649-55. 2010
    ..Erythromycin had the lowest activity (MIC₉₀ of 8 mg/L) against ureaplasmas like clindamycin which was the most potent agent against M. hominis...
  45. ncbi Clindamycin phosphate scavenges hydroxyl radical
    Emiko Sato
    New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan
    Int J Dermatol 46:1185-7. 2007
    b>Clindamycin phosphate (CLDMP) is effective against Gram-positive and anaerobic bacteria, and is known to have anti-inflammatory properties.
  46. pmc In vitro activity and interaction of clindamycin combined with dihydroartemisinin against Plasmodium falciparum
    M Ramharter
    Department of Parasitology, Institute for Tropical Medicine, University of Tuebingen, Germany ramhartergmx at
    Antimicrob Agents Chemother 47:3494-9. 2003
    ..This study was conducted to evaluate the antimalarial potential of clindamycin in combination with dihydroartemisinin in continuously cultured and in freshly isolated Plasmodium falciparum ..
  47. ncbi Detection and prevalence of inducible clindamycin resistance in staphylococci
    Gurdal Yilmaz
    Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University School of Medicine, 61080 Trabzon, Turkey
    J Med Microbiol 56:342-5. 2007
    ..The resistance to antimicrobial agents among staphylococci is an increasing problem. Clindamycin (CL) is considered to be one of the alternative agents in these infections...
  48. pmc Incidence of constitutive and inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci in a community and a tertiary care hospital
    Paul C Schreckenberger
    University of Illinois Medical Center at Chicago, Rm 238 CSB, M C 750, 840 S Wood St, Chicago, IL 60612, USA
    J Clin Microbiol 42:2777-9. 2004
    The incidences of inducible clindamycin resistance at two hospitals (an inner-city hospital and a suburban community hospital) were 7 and 12% for methicillin-resistant Staphylococcus aureus, 20 and 19% for methicillin-susceptible S...
  49. ncbi Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: a series of 116 consecutive patients
    G Gener
    Service de Dermatologie, Groupe Henri Mondor Albert Chenevier, AP HP, Creteil, France
    Dermatology 219:148-54. 2009
    ..Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available...
  50. ncbi Indications for therapy and treatment recommendations for bacterial vaginosis in nonpregnant and pregnant women: a synthesis of data
    Emilia H Koumans
    Division of STD Prevention, Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 35:S152-72. 2002
    ..The use of intravaginal clindamycin therapy, especially during the latter half of the second trimester and thereafter, appears to increase ..
  51. ncbi Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate
    Jong Oh Kim
    Dong A Pharm Co, Ltd, Yongin si, Kyunggi Do 449 905, South Korea
    Biol Pharm Bull 31:2277-82. 2008
    To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freeze-thawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA)...
  52. ncbi Clindamycin for intraincisional antibiotic prophylaxis in dermatologic surgery
    Michael J Huether
    Arch Dermatol 138:1145-8. 2002
    To assess the efficacy of intraincisional clindamycin therapy as an alternative to nafcillin treatment in decreasing the risk of postoperative wound infections in dermatologic surgery.
  53. ncbi A randomized prospective controlled trial of antibiotic prophylaxis in intraoral bone-grafting procedures: preoperative single-dose penicillin versus preoperative single-dose clindamycin
    J A Lindeboom
    Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Oral Maxillofac Surg 35:433-6. 2006
    ..patients undergoing local intraoral bone grafting randomly received either an oral single dose of 600 mg clindamycin or 2 g of the penicillin phenethicillin 1 h before incision...
  54. ncbi Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial
    Austin Ugwumadu
    Department of Obstetrics and Gynaecology, St George s Hospital, Blackshaw Road, SW17 0QT, London, UK
    Lancet 361:983-8. 2003
    ..We aimed to establish whether antibiotic treatment early in the second trimester might reduce these risks in a general obstetric population...
  55. pmc Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole
    M N Austin
    Magee Womens Research Institute, Pittsburgh, PA 15213 3180, USA
    J Clin Microbiol 43:4492-7. 2005
    ..women aged 18 to 45 with clinical and Gram stain evidence of BV were randomized to receive intravaginal clindamycin or metronidazole...
  56. pmc Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release
    Elizabeth A Coyle
    Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 47:1752-5. 2003
    An in vitro model was used to compare the effects of linezolid, clindamycin, and penicillin, alone and in combination, on streptococcal pyrogenic exotoxin A (SPE A) release against virulent group A streptococci (GAS)...
  57. ncbi No decrease in clindamycin susceptibility despite increased use of clindamycin for pediatric community-associated methicillin-resistant Staphylococcus aureus skin infections
    Jillian M Szczesiul
    Department of Pharmacy, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD, USA
    Pediatr Infect Dis J 26:852-4. 2007
    ..our institution revealed 98% of methicillin-resistant Staphylococcus aureus (MRSA) isolates were susceptible to clindamycin; however, beta-lactams were then the predominant empiric treatment...
  58. ncbi Lymphocyte subsets and specific IgG antibody levels in clindamycin-treated and untreated dogs experimentally infected with Babesia gibsoni
    Retno Wulansari
    Department of Veterinary Science, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan
    J Vet Med Sci 65:579-84. 2003
    ..carried out to clarify the role of lymphocyte subpopulations and Babesia-specific antibody on the treatment of clindamycin in dogs infected with B. gibsoni...
  59. ncbi Activity of fusidic acid against extracellular and intracellular Staphylococcus aureus: influence of pH and comparison with linezolid and clindamycin
    Sandrine Lemaire
    Cellular and Molecular Pharmacology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Clin Infect Dis 52:S493-503. 2011
    ..Emergence of multidrug-resistant Staphylococcus aureus has triggered a reassessment of fusidic acid (CEM-102, sodium fusidate)...
  60. ncbi Murine goblet cell hypoplasia during Eimeria pragensis infection is ameliorated by clindamycin treatment
    Muchammad Yunus
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Gakuen Kibamadai Nishi 1 1 Miyazaki 889 2192, Japan
    J Vet Med Sci 67:311-5. 2005
    ..The jejunal GC numbers were not affected by E. pragensis infection. Clindamycin treatment in the infected mice reduced numbers of intracellular parasites and significantly increased the ..
  61. pmc Differences in the Enterococcus faecalis lsa locus that influence susceptibility to quinupristin-dalfopristin and clindamycin
    Kavindra V Singh
    Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School Houston, 6431 Fannin, Houston, TX 77030, USA
    Antimicrob Agents Chemother 49:32-9. 2005
    ..lsa gene, encoding the putative ABC protein Lsa, influences resistance to quinupristin-dalfopristin (Q-D) and clindamycin (CLI). We have now found that, while cloned lsa from E...
  62. ncbi Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:11-7. 2004
    ..double-blind, vehicle-controlled, 12-week study that assessed the efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea...
  63. ncbi Clindamycin-primaquine versus pentamidine for the second-line treatment of pneumocystis pneumonia
    Tark Kim
    Department of Infectious Diseases, Asan Medical Center, 388 1 Pungnap 2dong, Songpa Gu, Seoul 138 736, Korea
    J Infect Chemother 15:343-6. 2009
    ..We compared the efficacy of clindamycin-primaquine (C-P) with that of pentamidine as a second line treatment for PCP...
  64. pmc The effect of calcium hydroxide on the steroid component of Ledermix and Odontopaste
    M Athanassiadis
    Australian Dental Manufacturing, Brisbane, QLD, Australia
    Int Endod J 44:1162-9. 2011
    ..To investigate the chemical interaction of calcium hydroxide with the corticosteroid triamcinolone acetonide in Ledermix Paste and in Odontopaste, a new steroid/antibiotic paste...
  65. ncbi Interaction of dihydrofolate reductase and aminoglycoside adenyltransferase enzyme from Klebsiella pneumoniae multidrug resistant strain DF12SA with clindamycin: a molecular modelling and docking study
    Shailesh K Shahi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    J Mol Model 19:973-83. 2013
    ..augmentin, co-trimoxazole, carbapenems, penicillins and cefoperazone, and was sensitive to clindamycin. Molecular characterization of the multidrug-resistance phenotype revealed the presence of a class 1 integron ..
  66. ncbi Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump
    Xuan Qin
    Microbiology Laboratory, A9601, Seattle Children s Hospital, 4800 Sand Point Way, NE, Seattle, WA 98105, USA
    Int J Antimicrob Agents 38:81-3. 2011
    ..e. erythromycin-susceptible but clindamycin-resistant...
  67. ncbi Frequent resistance of clinical group B streptococci isolates to clindamycin and erythromycin
    M D Pearlman
    Department of Obstetrics and Gynecology, The University of Michigan Health System, Ann Arbor 48109 0276, USA
    Obstet Gynecol 92:258-61. 1998
    To determine both the frequency of reported penicillin allergy in parturients and the frequency of resistance in vitro of clinical isolates of group B streptococci to clindamycin and erythromycin.
  68. ncbi Serum pharmacokinetics of clindamycin hydrochloride in normal dogs when administered at two dosage regimens
    Manolis N Saridomichelakis
    Clinic of Medicine and Laboratory of Pharmacology and Toxicology, School of Veterinary Medicine, University of Thessaly, Karditsa, Greece
    Vet Dermatol 22:429-35. 2011
    The aim of this cross-over study was to compare clindamycin pharmacokinetics in the serum of clinically normal dogs when administered orally at two dosage regimens (5...
  69. ncbi Efficacy of once-daily clindamycin hydrochloride in the treatment of superficial bacterial pyoderma in dogs
    P B Bloom
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, Michigan State University, East Lansing 48824-1314, USA
    J Am Anim Hosp Assoc 37:537-42. 2001
    Twenty-one dogs with canine superficial bacterial pyoderma were treated with clindamycin at a dosage of approximately 11 mg/kg body weight, q 24 hours, given orally for 14 to 42 days...
  70. pmc An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin
    Kavindra V Singh
    Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical School at Houston, 77030, USA
    Antimicrob Agents Chemother 46:1845-50. 2002
    Enterococcus faecalis isolates are resistant to clindamycin (CLI) and quinupristin-dalfopristin (Q-D), and this is thought to be a species characteristic...
  71. pmc Staphylococcus aureus ocular infection: methicillin-resistance, clinical features, and antibiotic susceptibilities
    Chih Chun Chuang
    Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan
    PLoS ONE 8:e42437. 2012
    ..aureus (MSSA) infections...
  72. ncbi Group B streptococci exposed to rifampin or clindamycin (versus ampicillin or cefotaxime) stimulate reduced production of inflammatory mediators by murine macrophages
    Kevin C Brinkmann
    Department of Pediatrics, University of Tennessee Health Science Center, Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, 38103, USA
    Pediatr Res 57:419-23. 2005
    ..7 murine macrophages with a type-Ia GBS isolate in the presence of ampicillin, cefotaxime, rifampin, clindamycin, or gentamicin, singly or in combination...
  73. ncbi Recovery of clindamycin from fermentation wastewater with nanofiltration membranes
    Anna Zhu
    Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China
    Water Res 37:3718-32. 2003
    Experiments were carried out on clindamycin's separation and recovery from clindamycin fermentation wastewater with nanofiltration (NF) membranes...
  74. pmc Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA
    J I Ross
    The Skin Research Centre, Department of Microbiology, University of Leeds, United Kingdom
    Antimicrob Agents Chemother 41:1162-5. 1997
    ..These mutations correspond to three of four phenotypic classes previously identified by using MIC determinations...
  75. ncbi Nodular cutaneous microsporidiosis in a patient with AIDS and successful treatment with long-term oral clindamycin therapy
    K E Kester
    Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC 20307 5100, USA
    Ann Intern Med 128:911-4. 1998
    ..In AIDS, nodular skin disease can result from various causes...
  76. pmc Molecular mechanisms by which rRNA mutations confer resistance to clindamycin
    Jacob Poehlsgaard
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Antimicrob Agents Chemother 49:1553-5. 2005
    The mechanisms by which rRNA mutations confer clindamycin resistance were examined in Mycobacterium smegmatis strains containing homogeneous populations of ribosomes with base substitutions at nucleotides A2058 and A2059...
  77. ncbi Intravitreal clindamycin and dexamethasone for zone 1 toxoplasmic retinochoroiditis at twenty-four months
    Andres F Lasave
    Retina and Vitreous Service, Clinica Oftalmologica Centro Caracas, Caracas, Venezuela
    Ophthalmology 117:1831-8. 2010
    To report the anatomic and functional outcomes of intravitreal clindamycin and dexamethasone for the treatment of zone 1 toxoplasmic retinochoroiditis (TRC)...
  78. pmc Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins
    Jason Yamaki
    University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Antimicrob Agents Chemother 55:4432-5. 2011
    ..TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and ..
  79. ncbi Empiric outpatient therapy with trimethoprim-sulfamethoxazole, cephalexin, or clindamycin for cellulitis
    Thana Khawcharoenporn
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Am J Med 123:942-50. 2010
    ..Limited data exist on optimal empiric oral antibiotic treatment for outpatients with cellulitis in areas with a high prevalence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections...
  80. pmc Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria
    Ronnatrai Ruangweerayut
    Mae Sot Hospital, Tak Province, Thailand
    Malar J 7:225. 2008
    This study investigated the pharmacokinetics of fosmidomycin when given in combination with clindamycin at two dosage regimens in patients with acute uncomplicated falciparum malaria.
  81. ncbi Successful pregnancy in a patient suffering from recurrent mid-trimester miscarriage with C9 deficiency after receiving cervical cerclage followed by clindamycin and progesterone: a case report
    Noriyoshi Watanabe
    Department of Maternal Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan
    J Obstet Gynaecol Res 38:562-6. 2012
    ..Her fifth pregnancy was successfully managed by cervical cerclage at 13 weeks' gestation, followed by clindamycin administration (600 mg/day for 7 days) and progesterone injections (250 mg/week)...
  82. ncbi Susceptibility of Zimbabwean Streptococcus agalactiae (group B Streptococcus; GBS) isolates to four different antibiotics
    S R Moyo
    Department of Medical Microbiology, University of Zimbabwe, Harare, Zimbabwe
    Cent Afr J Med 47:226-9. 2001
    ..To establish the susceptibility of Zimbabwean GBS strains isolated from hospitalised patients to four antibiotics...
  83. ncbi A randomised controlled trial of vaginal clindamycin for early pregnancy bacterial vaginosis
    M Kurkinen-Räty
    Department of Obstetrics and Gynaecology, Oulu University, Finland
    BJOG 107:1427-32. 2000
    To determine whether treatment of bacterial vaginosis (BV) with vaginal clindamycin affects pregnancy outcome.
  84. doi Clindamycin and metronidazole as independent risk factors for nosocomial acquisition of multidrug-resistant Pseudomonas aeruginosa
    R Cipriano Souza
    J Hosp Infect 69:402-3. 2008
  85. pmc The inhibitory effect of clindamycin on Lactobacillus in vitro
    A Aroutcheva
    Department of Obstetrics and Gynecology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA
    Infect Dis Obstet Gynecol 9:239-44. 2001
    OBJECTIVE: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp. METHODS: Concentrations of clindamycin ranging from 1...
  86. pmc Clindamycin-induced acute cholestatic hepatitis
    Cem Aygun
    Department of Gastroenterology, Kocaeli University Medical Faculty, Kocaeli 41380, Turkey
    World J Gastroenterol 13:5408-10. 2007
    We report a case of acute hepatotoxicity in a 42-year-old woman after administration of clindamycin for a dental infection. After 6 d of treatment, she had fatigue, nausea, vomiting, anorexia, pruritus and jaundice...
  87. ncbi Osteomyelitis of the jaw: resistance to clindamycin in patients with prior antibiotics exposure
    C Pigrau
    Hospital Universitari Vall d Hebron, Universitat Autonoma, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 28:317-23. 2009
    ..5% to clindamycin. Overall, 35/38 (92.1%) had at least one clindamycin-resistant isolate...
  88. ncbi Clindamycin vs. first-generation cephalosporins for acute osteoarticular infections of childhood--a prospective quasi-randomized controlled trial
    H Peltola
    Children s Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Clin Microbiol Infect 18:582-9. 2012
    ..We conducted a prospective, multicentre, quasi-randomized trial in Finland, comparing clindamycin with first-generation cephalosporins...
  89. pmc Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas
    Susana Chavez-Bueno
    University of Texas Southwestern Medical Center of Dallas, and Children s Medical Center of Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Antimicrob Agents Chemother 49:2283-8. 2005
    Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection occurs commonly in children. Clindamycin resistance may be inducible or constitutive, and the rates of inducible resistance in CA-MRSA that could produce ..
  90. ncbi Vaginal clindamycin and oral metronidazole for bacterial vaginosis: a randomized trial
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Obstet Gynecol 96:256-60. 2000
    To compare the efficacy and safety of clindamycin vaginal ovules with oral metronidazole for treatment of bacterial vaginosis.
  91. pmc Use of clindamycin disks To detect macrolide resistance mediated by ermB and mefE in Streptococcus pneumoniae isolates from adults and children
    K Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Clin Microbiol 38:1731-4. 2000
    ..pneumoniae isolates obtained from adults and children to evaluate whether 2-microgram clindamycin disks can distinguish between isolates manifesting ermB- versus mefE-mediated resistance to clarithromycin and ..
  92. ncbi High prevalence of erythromycin-resistant, clindamycin/miocamycin-susceptible (M phenotype) Streptococcus pyogenes: results of a Spanish multicentre study in 1998. Spanish Group for the Study of Infection in the Primary Health Care Setting
    J I Alos
    Servicio de Microbiologia, Hospital de Mostoles, 28935 Móstoles, Madrid Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logrono, Spain
    J Antimicrob Chemother 45:605-9. 2000
    ..dilution method we studied the prevalence of susceptibility to 14-, 15- and 16-membered ring macrolides and clindamycin in Streptococcus pyogenes isolated in 1998 from 21 laboratories in Spain...
  93. ncbi In vitro post-antibiotic effect of fluoroquinolones, macrolides, beta-lactams, tetracyclines, vancomycin, clindamycin, linezolid, chloramphenicol, quinupristin/dalfopristin and rifampicin on Bacillus anthracis
    A Athamna
    The Triangle Research and Development Center, Kfar Qaraa, Israel
    J Antimicrob Chemother 53:609-15. 2004
    ..The aim of this study was to investigate in vitro the post-antibiotic effect (PAE) of 19 antibacterial agents against two strains of Bacillus anthracis (ST-1 and Sterne strains)...
  94. pmc Clindamycin and taste disorders
    Mark C H De Groot
    Netherlands Pharmacovigilance Centre Lareb, s Hertogenbosch, The Netherlands
    Br J Clin Pharmacol 64:542-5. 2007
    Topical use of clindamycin has been associated with taste disorders in the literature, but little is known about the nature of this adverse drug reaction...
  95. pmc Fusidic acid and clindamycin resistance in community-associated, methicillin-resistant Staphylococcus aureus infections in children of Central Greece
    George D Katopodis
    Department of Pediatrics, University of Thessaly, Medical School, Biopolis, 411 10 Larissa, Greece
    BMC Infect Dis 10:351. 2010
    In Greece, fusidic acid and clindamycin are commonly used for the empiric therapy of suspected staphylococcal infections.
  96. pmc Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages
    Tetsuji Nakano
    Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879 5593, Japan
    Antimicrob Agents Chemother 47:363-7. 2003
    We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation...
  97. ncbi Hypersensitivity reaction to intravitreal clindamycin therapy
    Peter Kim
    Department of Ophthalmology, Prince of Wales Hospital, University of New South Wales, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 30:147-8. 2002
    A Caucasian woman presenting with recurrence of intra-ocular toxoplasmosis was given intravitreal clindamycin. She subsequently developed a hypersensitivity reaction in the form of a generalized erythematous rash...
  98. ncbi Treatment of contaminated bone defects with clindamycin-reconstituted bone xenograft-composites
    Long Bi
    Institute of Orthopaedics and Traumatology, Xijing Hospital, The Fourth Military Medical University, Xi an, People s Republic of China
    J Biomed Mater Res B Appl Biomater 82:418-27. 2007
    ..To find a better method to resolve this dilemma, we prepared a novel clindamycin-reconstituted bone xenograft-composite (C-RBX-C) that comprised of crude bBMP (bovine bone morphogenetic ..
  99. ncbi Invasive neonatal GBS infections from an area-based surveillance study in Italy
    M Imperi
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    Clin Microbiol Infect 17:1834-9. 2011
    ..Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible ..
  100. ncbi Clindamycin in the treatment of obstetric and gynecologic infections: a review
    D Zambrano
    Upjohn Company, Kalamazoo, Michigan
    Clin Ther 13:58-80. 1991
    The spectrum of clindamycin's activity includes anaerobes and gram-positive aerobes other than enterococci. No inactivation or incompatibility of clindamycin phosphate has been shown in intravenous solutions usually used clinically...
  101. pmc Pretreatment of mice with clindamycin improves survival of endotoxic shock by modulating the release of inflammatory cytokines
    N Hirata
    Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan
    Antimicrob Agents Chemother 45:2638-42. 2001
    ..We investigated the effect of clindamycin (CLI) on endotoxic shock induced in mice by Escherichia coli lipopolysaccharide (LPS)...

Research Grants58

  1. Candida-endothelial interactions under conditions of flow
    Martin Thornhill; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. International Congress on Microsporidiosis
    Louis Weiss; Fiscal Year: 2004
    ..Overall, the goal of this congress is to foster the exchange of information between these diverse groups of scientists leading to advances in research on these emergent pathogens. ..
  3. Second International Workshop on Microsporidia from Vertebrate and Invertebrate H
    Louis Weiss; Fiscal Year: 2007
    ..Overall, the goal of this[unreadable] congress is to foster the exchange of information between these diverse groups of[unreadable] scientists leading to advances in research on these emergent pathogens. ..
  4. TOXOPLASMA ENCEPHALITIS IN AIDS: BRADYZOITE REGULATION
    Louis Weiss; Fiscal Year: 2009
    ....
  5. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..ceftriaxone, will be used to cover Gram-negative and Gram-positive aerobic bacteria in combination with clindamycin to cover anaerobic bacteria...
  6. Maternal genitourinary infections and adverse perinatal outcomes
    Abdullah Hel Baqui; Fiscal Year: 2013
    ..infections between 12-16 weeks;those with abnormal vaginal flora (Nugent score >4) will be treated with oral clindamycin for 5 days, rescreened after 3 weeks, and those with persistent abnormal flora will be retreated with a second ..
  7. The Role of Uncultivated Bacteria in Bacterial Vaginosis
    DAVID NEAL FREDRICKS; Fiscal Year: 2013
    ..Although antibiotics such as metronidazole and clindamycin can be used to treat BV, recurrence is common, with recurrence rates of up to 30% at 3 months and >50% at ..
  8. Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) Trial
    Alan Thevenet N Tita; Fiscal Year: 2013
    ..prior to surgery;concurrently, both groups will also receive standard single-dose cefazolin prophylaxis (or clindamycin if allergic to cephalosporin)...
  9. Vaginal Ring for Preventing Bacterial Vaginosis
    THOMAS RAY MOENCH; Fiscal Year: 2010
    ..Episodes of BV can be treated transiently with antibiotics (metronidazole, clindamycin) but relapse occurs frequently. Women with BV typically have ~2 episodes per menstrual cycle...
  10. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    Robert S Daum; Fiscal Year: 2013
    ..We are proposing studies utilizing the patients enrolled in the DMID-funded "Randomized, Double-Blind Trial of Clindamycin, Trimethoprim-Sulfamethoxazole, or Placebo for Uncomplicated Skin and Soft Tissue Infections Caused by ..
  11. Innate Immune Defense against Clostridium Difficile Infection
    Eric G Pamer; Fiscal Year: 2013
    ..difficile infection. We have also demonstrated that a single dose of clindamycin results in prolonged susceptibility to C. difficile infection...
  12. Clinical Trial for CA-MRSA Infections
    DENISE TRITT; Fiscal Year: 2011
    ..objectives [unreadable] Efficacy determined at a Test of Cure Visit: [unreadable] To compare the efficacy of clindamycin and trimethoprim-sulfmethoxazole in conjunction with surgical drainage for suppurative uncomplicated skin and ..
  13. CLOSTRIDIUM DIFFICILE INFECTION
    JERGANG CHANG; Fiscal Year: 1991
    ..11 experimental groups to examine the susceptibility of aged hamsters to varied doses of inciting antibiotic - clindamycin - and simultaneous ingestion of C. difficile...
  14. DETECTION OF BIOMOLECULES BY CHEMILUMINESCENCE
    NEIL DANIELSON; Fiscal Year: 1990
    ..04 pmoles. Pharmaceuticals difficult to detect in the UV such as erythromycin and clindamycin-2-phosphate have been assayed easily at the ppb level...
  15. Oral Immunotherapy for C. difficile Disease via Bacteria
    Thomas Parks; Fiscal Year: 2005
    ..secreting scFv against toxins A and B will then be tested in a well-established animal model of CDAD, the clindamycin-treated hamster...
  16. Therapy and Prevention for Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2006
    ..The current therapy for BV consists of seven days of oral or topical metronidazole or clindamycin. However, there is a growing concern that eradication of organisms from the lower genital tract may be ..
  17. Primaquine-binding proteins identified in Pneumocystis
    SHERRY QUEENER; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Primaquine, an 8-aminoquinoline, with clindamycin is the most effective clinical alternative to standard therapy for patients with pneumonia caused by Pneumocystis, but the mechanism of ..
  18. ANTIBIOTIC RESISTANCE IN ORAL & COLONIC ANAEROBES
    FRANCIS MACRINA; Fiscal Year: 1992
    ..The emergence of resistance to the drug of choice, clindamycin (Ccr), and to other antibiotics threatens to compromise the treatment of Bacteroides infections...
  19. Tinidazole for the Treatment of Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2007
    ..Current treatments for BV with metronidazole or clindamycin are suboptimal with cure rates at approximately 70% and high recurrence rates...
  20. POTENTIATORS OF BACTERIOSTATIC ANTIBIOTICS IN GRAM +
    PENELOPE MARKHAM; Fiscal Year: 2000
    ..the lead of which, in combination with bacteriostatic concentrations of either erythromycin, chloramphenicol, clindamycin or tetracycline, is synergistically and rapidly bactericidal to S. aureus...
  21. BACTERIOPHAGE THERAPY IN C DIFFICILE INTESTINAL DISEASE
    Rial Rolfe; Fiscal Year: 2001
    ..Preliminary experiments demonstrate that administration of bacteriophage to hamsters, treated with clindamycin and a toxigenic strain of C. difficile, prevents development of a fatal ileocecitis...
  22. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
  23. Rural Trial of Clinic Order Entry with Decision Support
    Matthew Samore; Fiscal Year: 2006
    ..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. [unreadable] [unreadable]..
  24. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Modulation of Dendritic Cell Function by Cytomegalovirus
    JATIN VYAS; Fiscal Year: 2008
    ..The proposed program will allow the candidate to obtain the skills, knowledge and experience to become an independent investigator. ..
  26. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  27. Molecular Epidemiology, Virulence, and Genomic Characterization of Ureaplasmas
    Ken B Waites; Fiscal Year: 2010
    ....
  28. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ....
  29. Identification of Uncultivated and Unrecognized Pathogens of Periodontitis
    ANNE DENISE HAFFAJEE; Fiscal Year: 2010
    ..The identification of such pathogens should, over time, lead to better diagnosis of disease, optimal treatment strategies for the individual patient, new therapeutic approaches and carefully targeted approaches to prevention. ..
  30. TRANSMISSION OF PNEUMOCYSTIS INFECTION
    Melanie Cushion; Fiscal Year: 2001
    ..These studies will result in a clearer understanding of the biology leading to infection with Pc and will provide a rational basis for clinical management and therapeutic intervention. ..
  31. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
  32. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  33. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  34. EFFECT OF ANTIBIOTICS ON ORAL BIOFILMS IN VIVO
    Anne Haffajee; Fiscal Year: 2001
    ..abstract_text> ..
  35. GROUP A STREPTOCOCCAL INFECTIONS IN CHILDREN
    Judith Martin; Fiscal Year: 2004
    ....
  36. PNEUMOCYSTIS GENOME PROJECT
    Melanie Cushion; Fiscal Year: 2004
    ..Thus, there is but a single aim to this proposal: 1. To finish sequencing the genome of pneumocystis carinii and provide a completed assembly. ..
  37. Enteropathogenic and Toxigenic E.coli Interactions
    JOHN CRANE; Fiscal Year: 2004
    ..abstract_text> ..
  38. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
    ..coli (RDEC-1) and rabbit EPEC (REPEC). ..
  39. MATERNAL IMMUNIZATION TO PREVENT INFANT OTITIS MEDIA
    Patricia Ferrieri; Fiscal Year: 2005
    ..Results of this trial will have a profound impact on the broad field of maternal immunization to prevent early infant disease caused by a variety of infant bacterial and viral pathogens. ..
  40. Eighth International Workshops on Opportunistic Protists
    Melanie Cushion; Fiscal Year: 2003
    ..Mead's and Cushion's ancestors include native Americans; Marciano-Cabral is Hispanic; Kaneshiro has Pacific-Asian ancestry; Lindsay, Weiss are white. Lindsay is a physically handicapped individual. ..
  41. A Therapeutic Target for Microsporidiosis
    Louis Weiss; Fiscal Year: 2007
    ..In addition, the approaches and methods developed in this R21 should also prove useful for studies on methionine aminopeptidases as therapeutic targets in other pathogenic protists. [unreadable] [unreadable] [unreadable]..
  42. MICROBIAL ASSOCIATIONS IN PERIODONTAL HEALTH AND DISEASE
    Anne Haffajee; Fiscal Year: 2006
    ..These data will provide a basis for understanding microbial community structure, ecological relationships and define desired microbiological end-point of therapy. ..
  43. Efficient Mechanism of Gene Transfer in B. fragilis
    David Hecht; Fiscal Year: 2006
    ..abstract_text> ..
  44. ANTIBIOTIC RESISTANCE IN A SUBGINGIVAL BIOFILM MODEL
    Clay Walker; Fiscal Year: 2006
    ..We believe the information derived from the experiments described will provide a better understanding of the subgingival flora and the effects that antibiotics may have on this flora. ..
  45. Effect of Zinc in Enteropathogenic E. coli Infection
    JOHN CRANE; Fiscal Year: 2006
    ..abstract_text> ..
  46. ANTIBIOTIC INHIBITION OF BACTERIAL RIBOSOME FORMATION
    WILLIAM CHAMPNEY; Fiscal Year: 2002
    ..The findings from this work will help in assessing the effectiveness of existing antibiotics and in developing new compounds as antimicrobial agents. ..
  47. The Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne Marrazzo; Fiscal Year: 2006
    ..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
  48. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  49. New Approaches for Development of PcP Therapy
    Melanie Cushion; Fiscal Year: 2006
    ..Finally, they will select the most efficacious combinations of agents and evaluate their effects on gene expression again using the macroarray approach. ..
  50. Microsporidiosis:A Therapeutic Target
    Louis Weiss; Fiscal Year: 2003
    ....
  51. Infection, Inflammation and Preeclampsia
    Catherine Haggerty; Fiscal Year: 2009
    ..Finally, cytokine and CRP testing may prove to be effective tools for identifying women at risk for developing preeclampsia. ..
  52. Three Periodontal Therapies in Current & Non-Smokers
    Anne Haffajee; Fiscal Year: 2007
    ..The proposed investigation should provide a model to examine methods that could be useful in treating compromised patients whether compromised by harmful habits such as smoking, systemic disease, or genetic background. ..
  53. Mycoplasma Genitalium and Pelvic Inflammatory Disease
    Catherine Haggerty; Fiscal Year: 2007
    ..Exploring the role of M. genitalium in PID is imperative to optimize diagnosis and treatment and prevent reproductive morbidity among women with nongonococcal/nonchlamydial PID. ..
  54. Mechanisms of Tandem Repeat Deletion in Group B Strep
    KAREN PUOPOLO; Fiscal Year: 2006
    ..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..