Genomes and Genes
Summary: Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.
Publications231 found, 100 shown here
- Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokinesL E M Niers
Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Clin Exp Allergy 35:1481-9. 2005..Recent clinical trials suggested that probiotic bacteria may decrease and prevent allergic symptoms, but which (different) species or strains may contribute is poorly understood...
- Diminished percentage of CD4+ T-lymphocytes expressing interleukine-2 receptor alpha in chronic brucellosisPanagiotis Skendros
Clinical Immunology Unit, 2nd Department of Internal Medicine, Aristotle University, Konstantinoupoleos 49, 54642 Thessaloniki, Greece
J Infect 54:192-7. 2007..Simultaneously, CD3+, CD4+ and CD8+ T-lymphocytes subsets were measured...
- The perils and prospects of using phytohaemagglutinin in evolutionary ecologyMalcolm W Kennedy
Division of Ecology and Evolutionary Biology, Institute of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow, UK, G12 8QQ
Trends Ecol Evol 21:653-5. 2006....
- Evaluation of multitype mathematical models for CFSE-labeling experiment dataHongyu Miao
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
Bull Math Biol 74:300-26. 2012..This model was then employed to understand the proliferation pattern of CD4+ and CD8+ T cells under polyclonal stimulation...
- Nestling immune response to phytohaemagglutinin is not heritable in collared flycatchersNatalia Pitala
Bird Ecology Unit, Department of Biological and Environmental Sciences, PO Box 65, University of Helsinki, Helsinki 00014, Finland
Biol Lett 3:418-21. 2007..Our findings illustrate that full-sib comparisons of immunological measures may lead to an inflated estimate of heritability and also reveal a limited role of nestling PHA-response for sexual selection in this population...
- Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responsesY M Sjögren
Department of Immunology, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
Clin Exp Allergy 39:1842-51. 2009..Although animal and in vitro studies emphasize the role of the commensal gut microbiota in the development of the immune system, the influence of the gut microbiota on immune development in infants is unclear...
- Immunosenescence and age-related susceptibility to influenza virus in Japanese quailEmma T Lavoie
Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
Dev Comp Immunol 31:407-14. 2007..Our data demonstrate an age-related difference in immune function in Japanese quail that has similarities to age-related immunity in humans; younger and older animals had weaker immune responses compared to young adults...
- Differential gene expression profiles are dependent upon method of peripheral blood collection and RNA isolationAdam L Asare
University of California, San Francisco, Immune Tolerance Network, 3 Bethesda Metro Suite 400, Bethesda, MD 20814, USA
BMC Genomics 9:474. 2008..Because the RNA purification steps could influence the total RNA pool, we examined the impact of RNA isolation, using the PAXgene or Tempus method, on gene expression profiles...
- Differential activation of macrophages in vitro by lectin Concanavalin A, Phytohemagglutinin and Wheat germ agglutinin: production and regulation of nitric oxideVarun Kesherwani
School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
Nitric Oxide 16:294-305. 2007..The data also provides the relative measure and importance of different key signaling molecules in the regulation of NO production by macrophages on activation...
- Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatumS N Haber
Department of Neurobiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Neurosci 20:2369-82. 2000..This anatomical arrangement creates a hierarchy of information flow and provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain...
- Do dietary antioxidants alleviate the cost of immune activation? An experiment with greenfinchesPeeter Hõrak
Institute of Zoology and Hydrobiology, Tartu University, Vanemuise 46, 51014 Tartu, Estonia
Am Nat 170:625-35. 2007....
- Cell-mediated immunosenescence in birdsMark F Haussmann
Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa 50011, USA
Oecologia 145:270-5. 2005..This link between declining immune function and survival may reflect differences in resource partitioning between species, and suggests that selection may act on investment in immune function to influence maximum life span...
- Validation of immunotoxicology techniques in passerine chicks exposed to Oil Sands tailings waterJ E Smits
Western College of Veterinary Medicine, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan, S7N 5B3, Canada
Ecotoxicol Environ Saf 44:105-12. 1999....
- Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cellsI Monleon
Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
J Immunol 167:6736-44. 2001....
- Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratoryD Fulcher
Department of Immunopathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
Immunol Cell Biol 77:559-64. 1999....
- Sialoglycoconjugate expression in primary colorectal cancer and metastatic lymph node tissuesYoshinori Inagaki
Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Hepatogastroenterology 54:53-7. 2007..To investigate the clinicopathological significance of sialylation in colorectal cancer, we performed histochemical analyses using sialic acid-binding lectins...
- Mitogen stimulation activates different signaling pathways in early- and late-divided T cells as revealed by cDNA microarray analysisYufeng Li
Graduate School of Biomedical Science, UT Health Science Center at Houston, Houston, TX 77030, USA
Int J Mol Med 18:1127-39. 2006..Because most tumors are infiltrated by lymphocytes, our studies indicate a novel approach to identify 'systemic biological responses' of T cells, which could determine the design, and optimization of effective tumor vaccines...
- The PHA test reflects acquired T-cell mediated immunocompetence in birdsJose L Tella
Department of Conservation Biology, Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain
PLoS ONE 3:e3295. 2008..However, mechanisms involved in local immunological and inflammatory processes provoked by PHA are poorly known, and its use and interpretation as an acquired immune response is currently debated...
- An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrowCamille Bonneaud
Laboratoire de Parasitologie Evolutive CNRS UMR 7103, Universite Pierre et Marie Curie Paris 6, 7 quai St Bernard, bât A 7e étage, Case 237, Paris Cedex 05 75252, France
Immunogenetics 57:782-9. 2005..Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species...
- Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cellsA N Akbar
Department of Immunology, Royal Free Hospital School of Medicine, London, United Kingdom
J Immunol 140:2171-8. 1988..The recovery of virtually all alloantigen induced secondary proliferative response in the UCHL1+,CD45R- T cell population suggests that UCHL1 identifies a primed population of T cells which may include memory cells...
- Kidney bean lectin-induced Escherichia coli overgrowth in the small intestine is blocked by GNA, a mannose-specific lectinA Pusztai
Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
J Appl Bacteriol 75:360-8. 1993..Thus, GNA and perhaps other mannose-specific lectins, especially when used in a preventive mode, can be used to specifically block the proliferation of Type 1 E. coli in the small intestine...
- High interleukin-13 production by phytohaemagglutinin- and Der p 1-stimulated cord blood mononuclear cells is associated with the subsequent development of atopic dermatitis at the age of 3 yearsJ Lange
University Children s Hospital, Freiburg, Germany
Clin Exp Allergy 33:1537-43. 2003....
- Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cellsWilco de Jager
Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children s Hospital, 3584 EA Utrecht, The Netherlands
Clin Diagn Lab Immunol 10:133-9. 2003..It will provide a more complete picture in differences between activated lymphocyte cytokine profiles from healthy individuals and those from patients with chronic inflammatory diseases...
- Antibody microarray analysis of inflammatory mediator release by human leukemia T-cells and human non small cell lung cancer cellsBradley H Garcia
Thermo Fisher Scientific, 3747 N Meridian Road, Rockford, IL 61105, USA
J Biomol Tech 18:245-51. 2007..Our experiments clearly demonstrate the utility of antibody microarray analysis of cell-culture supernatants for the profiling of cellular inflammatory mediator release...
- Direct targeting of cancer cells: a multiparameter approachEileen L Heinrich
Department of Biology and Center for Cancer and Developmental Biology, California State University Northridge, 18111 Nordhoff St, Northridge, CA 91330 8303, USA
Acta Histochem 107:335-44. 2005....
- Genetic diversity predicts pathogen resistance and cell-mediated immunocompetence in house finchesDana M Hawley
Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
Biol Lett 1:326-9. 2005..Overall, our results underscore the importance of multilocus heterozygosity for individual pathogen resistance and immunity...
- Synaptic convergence of motor and somatosensory cortical afferents onto GABAergic interneurons in the rat striatumSankari Ramanathan
Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, OX1 3TH, United Kingdom
J Neurosci 22:8158-69. 2002..Furthermore, our findings suggest that the pattern of innervation of GABAergic interneurons by cortical afferents is different from the cortical innervation of spiny projection neurons...
- Where are the parasites in the PHA response?Jeb P Owen
Trends Ecol Evol 22:228-9. 2007
- Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated populationRabia Hussain
Department of Microbiology, The Aga Khan University, P O Box 3500, Stadium Road, Karachi, Pakistan
J Immunol Methods 264:95-108. 2002..015; CFP, p=0.05) and IL5 (PPD, p=0.05; CFP, p=0.015). Cytokine analysis in WB cultures is, therefore, able to discriminate between active tuberculosis infection and nondiseased healthy controls...
- Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune functionManjula Reddy
Department of Clinical Pharmacology, Centocor, 145 King of Prussia Road, Radnor, PA 19087 4517, USA
J Immunol Methods 293:127-42. 2004..This study defines the kinetics for both measures of T cell activation and provides a comprehensive review with various polyclonal activators that can serve as a reference for monitoring lymphocyte function in clinical study samples...
- Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cellsChristiana Winkler
Biocenter, Division of Biological Chemistry, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
Food Chem Toxicol 44:2003-7. 2006..01 at 1 mM sodium sulfite and 50 mM sorbic acid). Data demonstrate a suppressive influence of sodium sulfite and sorbic acid on the activated Th1-type immune response...
- Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitroBarbara Wirleitner
Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
Immunol Lett 100:159-63. 2005....
- Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seedsX Y Ye
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT
J Protein Chem 20:367-75. 2001..It exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani. The lectin had low ribonuclease and negligible translation-inhibitory activities...
- Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent hostsR K Katial
Department of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC 20307, USA
Clin Diagn Lab Immunol 5:78-81. 1998..The mitogens used were concanavalin A, phytohemagglutinin, pokeweed mitogen, and Staphylococcus aureus Cowen. The results obtained provide a normal range for the production of these cytokines under specified conditions in vitro...
- CD80/CD28 co-stimulation in human brucellosisP Skendros
Clinical Immunology Unit, 2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Clin Exp Immunol 146:400-8. 2006..We speculate that differential frequency of CD80(+) monocytes after PHA stimulation could serve as a qualitative parameter of disease status, related to the different clinical forms of chronic brucellosis...
- Involvement of P-gp in the process of apoptosis in peripheral blood mononuclear cellsA Pawlik
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, Al Powstancow Wlkp 72, Poland
Int Immunopharmacol 5:821-8. 2005..Moreover these agents significantly increased the apoptosis induced by MTX, DEX, MP and COR. The results of this study suggest that P-gp is involved in the process of apoptosis in peripheral blood mononuclear cells...
- Temporal dynamics of a T-cell mediated immune response in desert rodentsJoëlle Goüy de Bellocq
Mitrani Department of Desert Ecology, Jacob Blaustein Institutes for Desert Research, Ben Gurion University of the Negev, Sede Boqer Campus, 84990 Midreshet Ben Gurion, Israel
Comp Biochem Physiol A Mol Integr Physiol 145:554-9. 2006....
- Differential resource allocation in deer mice exposed to sin nombre virusErin M Lehmer
Department of Biology, Fort Lewis College, Durango, Colorado, USA
Physiol Biochem Zool 80:514-21. 2007..We propose that differences in resource allocation between males and females could result from inherent sex-based differences in parental investment...
- Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradationGozde Girgin
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
Immunobiology 214:129-34. 2009..The suppression of tryptophan degradation by propolis extracts may therefore be related with some of its beneficial health properties in humans...
- Isolation, cryopreservation, and mitogenesis of peripheral blood lymphocytes from chickens (Gallus domesticus) and wild herring gulls (Larus argentatus)E T Lavoie
Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, 20742, USA
Arch Environ Contam Toxicol 48:552-8. 2005..The magnitudes of proliferation responses were similar to that for chicken lymphocytes. These methods have subsequently proven useful in ecotoxicology studies that involve species in remote locations...
- Epstein-Barr virus and cytomegalovirus are differentially associated with numbers of cytokine-producing cells and early atopyC Nilsson
Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden
Clin Exp Allergy 39:509-17. 2009..We hypothesize that early exposure to EBV or CMV will affect the cytokine balance in the individual...
- High expression of alpha 2, 3-linked sialic acid residues is associated with the metastatic potential of human gastric cancerFeng Ling Wang
Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China
Cancer Detect Prev 32:437-43. 2009..Herein, we measured the expression of alpha 2, 3-linked sialic acid residues by using a specific lectin as well as the potential of invasion and metastasis of gastric cancer was analyzed...
- Activation and up-regulation of phospholipase D expression by lipopolysaccharide in human peripheral T cellsEileen Jea Chien
Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
Chin J Physiol 47:203-9. 2004..This indicated that LPS might enhance T cell adaptive immunity to resist Gram-negative bacterial infection...
- In vitro nonspecific mitogenic response of T-cell subsets in acute and chronic brucellosisSami Kinikli
Department of Clinic Microbiology and Infection Diseases, Ministry of Health Ankara Hospital, Ankara, 06100 Sihhiye, Turkey
Diagn Microbiol Infect Dis 52:229-33. 2005....
- Major histocompatibility (B) complex and sex effects on the phytohaemagglutinin wattle responseR L Taylor
Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824
Anim Genet 18:343-50. 1987..The developmental and early resolution phases of the PHA wattle response were influenced by sex while the late resolution phase was influenced by B genotype...
- Dual effects of extracellular adherence protein from Staphylococcus aureus on peripheral blood mononuclear cellsAxana Haggar
Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
J Infect Dis 192:210-7. 2005..Our results demonstrate novel immunomodulatory activities of Eap and identify potential mechanisms of action of intravenous IgG therapy in the treatment of S. aureus infections...
- Artesunate and a major metabolite, dihydroartemisinin, diminish mitogen-induced lymphocyte proliferation and activationP Veerasubramanian
Department of Immunology and Medicine, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 37:838-47. 2006..Artesunate and DHART may diminish some PBMC responses to immunologic stimuli. Further work is warranted to define the mechanisms involved, and whether this affects malaria treatment...
- Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infectionJie Yu
Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Med Virol 78:1147-57. 2006..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
- In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: a regulatory role for zincRoberto Paganelli
Department of Medicine, University, G D Annunzio, Chieti, Italy
J Trace Elem Med Biol 17:11-5. 2003..Our data are consistent with the hypothesis that Zn and Ni, as part of the heavy transition metals, may exchange roles in immune-mediated phenomena leading to expression of allergic contact dermatitis...
- Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host diseaseRosa Yañez
Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energeticas, Medioambientales y Technologicas CIEMAT Marcelino Botín Foundation, Madrid, Spain
Stem Cells 24:2582-91. 2006..These findings constitute the first experimental proof that Ad-MSCs can efficiently control the GVHD associated with allogeneic hematopoietic transplantation, opening new perspectives for the clinical use of Ad-MSCs...
- Dendritic cell culture: a simple closed culture system using ficoll, monocytes, and a table-top centrifugeChristina M Celluzzi
Blood and Cell Therapy Development Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855 2743, USA
J Hematother Stem Cell Res 12:575-85. 2003..The procedure is relatively fast (effective working time 5-6 h), does not impair monocyte function or induce substantial cell activation, and can be performed economically using equipment found in a typical blood banking environment...
- Combination of monocyte-derived dendritic cells and activated T cells which express CD40 ligand: a new approach to cancer immunotherapyTakami Sato
Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Immunol Immunother 53:53-61. 2004..ATs also migrated toward the MIP-3beta. These results suggest a combination of DCs and ATs as a potentially effective therapeutic strategy...
- Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cellsK Schroecksnadel
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Clin Exp Immunol 134:53-6. 2003..We conclude that in supernatants of stimulated peripheral blood mononuclear cells homocysteine is accumulating. T cell activation could be involved in the development of moderate hyperhomocysteinaemia...
- Inhibition of lymphocyte proliferation by prenylated flavones: artelastin as a potent inhibitorF Cerqueira
Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto, Porto, Portugal
Life Sci 73:2321-34. 2003..However, it decreased the production of IFN-gamma, IL-2, IL-4 and IL-10 in ConA-stimulated splenocytes. Furthermore, artelastin had no effect on apoptosis of splenocytes...
- Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alphaS M Dai
Department of Bioregulation, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8512, Japan
Ann Rheum Dis 63:1379-86. 2004..To determine whether IL18 has any indirect effects on osteoclastogenesis mediated by T cells in RA synovium, and compare its effects with those of IL1 beta and TNF alpha...
- Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cellYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
Immunol Lett 108:78-87. 2007..Our findings may advance our understanding of the immunobiology of stem cells and facilitate the therapeutic application of cord blood stem cells...
- Effect of lead exposure on the immune response of some occupationally exposed individualsKamla Prasad Mishra
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, 226 014, Lucknow, India
Toxicology 188:251-9. 2003..In brief, this study demonstrates that lead can affect the immune response of the occupationally exposed individuals such as three-wheeler drivers, battery reconditioning workers and silver jewelery makers...
- Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter studyWayne G Shreffler
Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
BMC Immunol 7:29. 2006....
- Specific stimulation of peripheral blood mononuclear cells from patients with acute myocarditis by peptide-bound flavin adenine dinucleotide (FAD), a naturally occurring autologous haptenG Cicek
Institute for Biochemistry and Molecular Biology, University of Freiburg, Germany
Clin Exp Immunol 132:366-70. 2003..The results are consistent with a recall response by activated T cells, specific for the normally cryptic mitochondrial flavin-hapten, which may be liberated following cardiomyocyte destruction during the inflammation of the heart...
- Effect of the chlorpropamide and fructose-1,6-bisphosphate of soluble TNF receptor II levelsFernanda B Nunes
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Pharmacol Res 49:449-53. 2004..In this way it acts as a powerful immunomodulatory agent...
- In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cellsC Winkler
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Planta Med 70:205-10. 2004..The findings imply a potential application of the extracts as immunoregulators and would be in line with observations in patients using these extracts...
- In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101M Shohat
Department of Dermatology and Cellular Immunology Unit, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
Clin Exp Dermatol 30:432-4. 2005..AS-101 inhibited the production of IL-10, IFNgamma, IL-2R and IL-5 in both PAA patients and controls, but there was a greater inhibitory effect in children with PAA...
- Cutaneous lymphocyte antigen expression on activated lymphocytes and its association with IL-12R (beta1 and beta2), IL-2Ralpha, and CXCR3Manjula Reddy
Department of Clinical Pharmacology and Experimental Medicine, Centocor Inc, 145 King of Prussia Road, Radnor, PA 19087 4517, USA
Cell Immunol 236:131-9. 2005....
- Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasoneAndrzej Pawlik
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, ul Powst Wlkp 72, Poland
Eur J Pharmacol 528:27-36. 2005..Moreover, determination of C3435T and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with methotrexate and dexamethasone...
- Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitisS L Prescott
School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
Clin Exp Allergy 35:1557-64. 2005..The purpose of this study was to determine the underlying immunological effects that are associated with these apparent clinical benefits...
- [Activation of transcriptional factors stat5 and stat3 during human T-lymphocyte proliferation induced by different mitogenic stimuli]I A Karitskaia
Tsitologiia 48:42-9. 2006..Taken together, we report that the increased STAT5 phosphorylation can serve as a marker of T-lymphocyte entrance into IL-2-dependent stage of proliferation after T-cell activation by different mitogens...
- Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cellsEileen Jea Chien
Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
J Cell Biochem 99:292-304. 2006..Progesterone might act directly through membrane specific nonclassical steroid receptors to cause immunomodulation and suppression of T-cell activation during pregnancy...
- Redirection of cytokine production by lymphocytes from women with pre-term delivery by dydrogesteroneRaj Raghupathy
Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
Am J Reprod Immunol 58:31-8. 2007..To study the ability of dydrogesterone to modulate the production of pro-inflammatory and anti-inflammatory cytokines by lymphocytes from women undergoing pre-term delivery (PTD)...
- Effects of ribavirin on cytokine production of recall antigens and phytohemaglutinin-stimulated peripheral blood mononuclear cells. (Inhibitory effects of ribavirin on cytokine production)Silvia Sookoian
Gastroenterology Section, Internal Medicine Department, Hospital JM Penna, GCBA
Ann Hepatol 3:104-7. 2004..To evaluate the effects of ribavirin on cytokine production of recall antigen and PHA-stimulated PBMC obtained from healthy individuals...
- Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: a preliminary studyMarta Kubera
Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
Neuro Endocrinol Lett 25:207-10. 2004..The biological basis of treatment resistance in depression still remains unclear. Some studies suggest that there exists a relationship between a disturbance in the immune system and depression...
- Influence of carbohydrate and age on lymphocyte function following a marathonDru A Henson
Department of Biology, Appalachian State University, Boone, NC 28608, USA
Int J Sport Nutr Exerc Metab 14:308-22. 2004..This decrease occurred in both younger and older runners and was not influenced by carbohydrate...
- Nuclear factor kappa B activation in human cord blood mononuclear cellsChristian H Schroeter
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, U S A
Pediatr Res 56:212-8. 2004..Whether differential NF-kappaB activity in cord blood is related to the subsequent development of immune diseases requires further investigation...
- Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammationDirk Reinhold
Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Int Immunopharmacol 6:1935-42. 2006....
- The extracts from Nelumbo Nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cellsChih Peng Liu
Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
Life Sci 75:699-716. 2004....
- Functional and molecular aspects of transient T cell unresponsiveness: role of selective interleukin-2 deficiencyM D Köller
Department Internal Medicine III, Division of Rheumatology, University of Vienna, Austria
Clin Exp Immunol 132:225-31. 2003..Despite the lack of proliferation, preactivated Tc phenotypically maintain an intermediate stage of activation. These data show how the same cell population can change its functional phenotype into a non-responder state...
- Immunomodulatory effects of glatiramer acetate on superantigen- and mitogen-induced T-cell stimulation in vitroS Schmidt
Department of Neurology, University of Bonn, Germany
Mult Scler 8:307-9. 2002....
- Inhibition of HIV infection by the cytokine midkineC Callebaut
, URA 1930 CNRS, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France
Virology 281:248-64. 2001..The potent and distinct anti-HIV action of MK along with its enhanced expression in lymphocytes by various physiological stimuli suggests that MK is a cytokine that could be implicated in HIV-induced pathogenesis...
- APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signalingCosimo Tortorella
Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Clinica Medica II, Policlinico, 70124, Bari, Italy
Mech Ageing Dev 123:1389-402. 2002..Taken together, the data outline the role of CD28 and IL-12/IL-15 signaling impairment in T cell proliferative deficiency during senescence...
- Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum OhwiY C Kuo
Laboratory of Biochemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
Inflamm Res 50:73-82. 2001..CONCLUSIONS: We hypothesize that the inhibitory mechanisms of emodin on activated T cells proliferation are related to the impairment of cytokine production, IL-2 mRNA level and [Ca2+]i in the cells...
- Proliferative suppression and class I insufficiency on peripheral blood cells from hepatitis C patients overcome by exogenous cytokines or high-dose mitogenPam Kimball
Department of Surgery and Hepatology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia, USA
Clin Immunol 103:317-23. 2002..01) but not HLA antigen content (P = ns). The results show a biochemical and functional abnormality in PBLs from HCV+ individuals, which may contribute to HCV chronicity...
- An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitroA M Kamal
Academic Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
Clin Exp Allergy 31:1116-25. 2001..Although it has been shown to inhibit "macroscopic" inflammatory processes in animal models, its direct effects on antigen-activated human T cells have not been studied...
- Immunomodulatory effect of concentrated lime juice extract on activated human mononuclear cellsM Gharagozloo
Immunology Department, Medical School, Shiraz University of Medical Sciences, PO Box 71345-1798, Shiraz, Iran
J Ethnopharmacol 77:85-90. 2001..Considering these data, it can be concluded that the CLJ extract possesses immunomodulatory principles, which may mainly be due to the protein components of the extract...
- Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patientsV Sanchez-Margalet
Department of Clinical Biochemistry, Internal Medicine, Virgen Macarena University Hospital, Seville, Spain
Clin Exp Immunol 129:119-24. 2002..These results are consistent with the suggested role of leptin in modulating the immune response...
- Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cellsE Zvetkova
Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Sciences, Sofia
Int Immunopharmacol 1:2143-50. 2001..Green and black tea extracts displayed similar immunomodulatory properties in our in vitro system, whereas C. latifolium (L.) extracts seemed to be more effective in reducing neopterin formation in stimulated cells...
- A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholdsJ Rachmilewitz
Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Blood 98:3727-32. 2001..These findings suggest a novel paradigm for immunoinhibition wherein negative regulators can finely tune, rather than inactivate, T-cell responses, and thereby skew the cytokine output of immunologic responses...
- Respiratory syncytial virus fusion protein mediates inhibition of mitogen-induced T-cell proliferation by contactJörg Schlender
Max von Pettenkofer Institute and Gene Center, Ludwig Maximilians University Munich, D 81377 Munich, Germany
J Virol 76:1163-70. 2002..However, a significant fraction of PBLs were delayed or defective in G0/G1 to S-phase transit...
- Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritisK Miyake
Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Rheumatology (Oxford) 41:518-24. 2002..To clarify whether the interferon-gamma (IFN-gamma) gene (IFNG) is associated with the histological phenotype of lupus nephritis...
- Cytokine release by activated T-cells in large granular lymphocytic leukemia associated with autoimmune disordersLev Shvidel
Hematology Institute, Kaplan Medical Center, Rehovot, Israel
Hematol J 3:32-7. 2002..The pathogenesis of associated T-LGLL and autoimmune abnormalities is not clear. In this study we have investigated the role of cytokines in the development of immune complications in LGLL...
- Detection of the genes induced in activated lymphocytes by modified differential displayHideo Kaneko
Department of Pediatrics, Gifu University School of Medicine, Japan
J Investig Allergol Clin Immunol 12:86-90. 2002..Differential display is a useful method for detection of inducible genes from a small amount of material and at various time points, although the homology of PCR primer influences the displayed genes...
- ELISpot and ELISA analysis of spontaneous, mitogen-induced and antigen-specific cytokine production in cynomolgus and rhesus macaquesBarbro Mäkitalo
Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
J Immunol Methods 270:85-97. 2002..The establishment of reliable immunoassays for detection of macaque cytokines is of importance for future progress of research utilizing macaques as experimental animals...
- Analysis of leukemia inhibitory factor, type 1 and type 2 cytokine production in patients with eosinophilic fasciitisJ F Viallard
, , Pessac, France
J Rheumatol 28:75-80. 2001..In this context, the simultaneous elevations of type 1 cytokines (IL-2 and IFN-gamma) and LIF production by the same cells may be an attempt by the immune system to limit the exacerbation of a type 2 dominant response...
- Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulationT Hernandez-Caselles
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
J Immunol 151:3999-4012. 1993..Our studies show that TNF might have unique and complex regulatory effects on growth and death of thymocyte populations in adult mice quite different from its effects on T cells in periphery...
- Upregulation of cyclin T1/CDK9 complexes during T cell activationJ Garriga
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Oncogene 17:3093-102. 1998....
- Regulatory effects of cytokines and cyclosporine A on peripheral blood mononuclear cells from stable multiple sclerosis patientsC Guillen
Departamento de Medicina,
Immunopharmacol Immunotoxicol 21:527-49. 1999..Cyclosporine A (CsA) inhibited the PR and the expression of activation antigens induced by PHA in PBMC from the three groups of subjects. This inhibitory effect of CsA have was enhanced by the addition of IFN-alpha...
- [The effect of mycophenolic acid on activation antigen expression and in vitro T lymphocytes proliferation in peripheral blood]Weiyan Zheng
The Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China
Zhonghua Nei Ke Za Zhi 41:329-32. 2002..To explore the effect of mycophenolic acid (MPA) on activation and proliferation of T lymphocytes in vitro...
- Simian immunodeficiency viruses with defective nef genes show increased susceptibility to the noncytotoxic antiviral activity of CD8+ lymphocytesDoris Binninger-Schinzel
Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany
Virology 294:209-21. 2002....
- Gingipains in the culture supernatant of Porphyromonas gingivalis cleave CD4 and CD8 on human T cellsY Kitamura
Department of Periodontology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
J Periodontal Res 37:464-8. 2002..These results suggest that cysteine proteinases like gingipains released from P. gingivalis cleave T cell surface proteins and impede T cell function...
- Molecular characterization of a new member of the immunoglobulin superfamily that potentially functions in T-cell activation and developmentD M Ruble
Department of Animal Science, University of Minnesota, St Paul 55108, USA
Immunogenetics 51:347-57. 2000..Sequence similarities and expression patterns suggest that cTADS could be involved in cell recognition and adhesion, and/or peptide ligand binding...
- Altered glucocorticoid immunoregulation in treatment resistant depressionMoisés E Bauer
Department of Microbiological Sciences, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, 90619 900 Porto Alegre, RS, Brazil
Psychoneuroendocrinology 28:49-65. 2003..Our data indicate that alterations in immune function and steroid regulation associated with depression are not related to elevated basal levels of cortisol and suggest that lymphocyte steroid resistance may be associated with TRP...
- Evaluation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCRIn Soo Choi
Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, South Korea
FEMS Immunol Med Microbiol 34:119-26. 2002..In alveolar macrophages and PBMC, however, IL-12 p 35 showed a higher expression than IL-12 p40. These results indicate that each cytokine has its own characteristic expression profile in different immune cells...
- Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBFI Kalousek
Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Cell Mol Biol (Noisy-le-grand) 46:1163-71. 2000....
- HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITSCRAIG HENKEL; Fiscal Year: 2005....
- Clinical Relevance of Transient Nevirapine ResistanceLouise Kuhn; Fiscal Year: 2008..unreadable] [unreadable]..
- Spatial aspects of coding in piriform cortexKURT ILLIG; Fiscal Year: 2007..abstract_text> ..
- STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMSCRAIG HENKEL; Fiscal Year: 2002..Results should lead to a better understanding of the influence of experience on the development of these binaural sensory pathways. ..
- Fine Structure of Lamina I TSST Terminals in VPArthur Craig; Fiscal Year: 2004..These studies will advance our understanding of the anatomical substrates for pain sensation in the primate thalamus. ..
- Physiology of Lamina I and V STT CellsArthur Craig; Fiscal Year: 2005..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
- Lamina I and HomeostasisArthur Craig; Fiscal Year: 2005..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
- CIRCUITRY CONTROLLING THE HIPPOCAMPAL THETA RHYTHMROBERT VERTES; Fiscal Year: 2002..This work may have important implications for conditions such as Alzheimer's that involve a loss of cholinergic neurons of the MS/DBv. ..
- Brainstem-Diencephalic Modulation of the HippocampusROBERT VERTES; Fiscal Year: 2006..This work may have important implications for disorders of memory including Korsakoff's syndrome, diencephalic amnesia and Alzheimer's disease. ..
- HIV Protective Immunity and Perinatal ExposureLouise Kuhn; Fiscal Year: 2006..abstract_text> ..
- Pathogenesis of Essential Tremor: Cerebellar MetabolismElan Louis; Fiscal Year: 2008..abstract_text> ..
- Modeling, Estimation and Control in HIV DynamicsH Banks; Fiscal Year: 2005....
- Novel Targets of the Von Hippel Lindau GeneWilliam Rigby; Fiscal Year: 2006..We hypothesize that the absence of pVHL results in the activation of the p38 SAPK pathway and hnRNP A2 overexpression and propose to address this and its relevance to GLUT1 mRNA turnover. ..
- NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITIONNEAL BARMACK; Fiscal Year: 2005..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
- FUNCTIONAL NEUROANATOMY OF MOVEMENT DISORDERSLucy Brown; Fiscal Year: 2006..The studies may provide clues to the function of the gene huntingtin, and define a target for therapeutic strategies. In addition, these studies address the plastic and proliferative capacity of the adult brain. ..
- Psychoneuroimmunology and Mind-Body InterventionsJanice Kiecolt Glaser; Fiscal Year: 2006..unreadable] [unreadable]..
- Chemoanatomic bases for peripheral vestibular functionGAY HOLSTEIN; Fiscal Year: 2007..The proposed research is unique, and will have direct bearing on the development of more effective therapeutic interventions, both medicinal and device-oriented, for peripheral vestibular disorders. [unreadable] [unreadable] [unreadable]..
- REGULATION OF CD154 EXPRESSIONWILLIAM FREDERICK CARSON RIGBY; Fiscal Year: 2010..Importantly, the CD153'UTR CA repeats are polymorphic with certain alleles associated with CD154 overexpression and the development of RA and SLE. ..
- Broad-Spectrum Antagonist of Superantigen ToxinsRaymond Kaempfer; Fiscal Year: 2008..A superantigen therapeutic resulting from the proposed effort offers a special opportunity in biodefense. PERFORMANCE SITE ========================================Section End=========================================== ..
- The Neural Network of Deep Brain Stimulation in OCDSuzanne Haber; Fiscal Year: 2009..A better understanding of the underlying neural circuitry of psychiatric disorders is a key element for developing the next generation of effective treatments. ..
- AUTOIMMUNITY AND CONNECTIVE TISSUE BIOLOGY TRAININGWilliam Rigby; Fiscal Year: 2008..These forums facilitate the high level of faculty-student interaction that is traditional at Dartmouth and results in the recognition of our research efforts at both the national and international level. [unreadable] [unreadable]..
- TNF Alpha In InflammationKathleen Sullivan; Fiscal Year: 2008..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. [unreadable] [unreadable]..
- Reward, Compulsions and Habit FormationSuzanne Haber; Fiscal Year: 2007..2005; Kelley and Berridge, 2002), as well as the commonalities and differences in other compulsive disorders such as OCD and Tourette's Syndrome. [unreadable] [unreadable] [unreadable]..
- SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALAALEXANDER MCDONALD; Fiscal Year: 2007..unreadable] [unreadable]..
- Immune Complex Stimulation of TNFalphaKathleen Sullivan; Fiscal Year: 2007..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
- Regulation and Development of the Prefrontal CortexSuzanne Haber; Fiscal Year: 2005..A specific emphasis is on recruiting young scientists to the field. Therefore each workshop will engage at least one young scientist in a leadership role, (as facilitator, scribe, or presenter). ..
- Form/function of Extended Amygdala/Accumbens Shell:CRFDANIEL ZAHM; Fiscal Year: 2005....
- Dopamine system plasticity after a partial lesionSuzanne Haber; Fiscal Year: 2005....
- Regulation of CD154 gene expression in vivoWilliam Rigby; Fiscal Year: 2002..As a result, we will create a model system with which to study its unique regulation and possibly develop novel approaches to regulating its biosynthesis. ..
- BASAL GANGLIA--CHEMICAL AND FUNCTIONAL CIRCUITRYSuzanne Haber; Fiscal Year: 2002..These studies will link together how the OMPFC and thalamic inputs to the VS are related to the shell and core sub-territories, and the mu and GluR1 receptors and follow the outputs via the VP/SNr to the MD. ..
- T CELL RECONSTITUTION AFTER STEM CELL AUTOGRAFTINGJan Storek; Fiscal Year: 2003..This will give impetus for developing strategies to enable older patients to generate T cells from hemopoietic progenitors, e.g., using thymopoietic cytokines or thymus grafting. ..
- Role of Complement Proteins in E. coli MeningitisPRASADARAO NEMANI; Fiscal Year: 2003..coli invasion of BMEC, and 2. To assess the effect of anti-OmpA antibody, OmpA-peptides, and C4BP-peptides on E. coli invasion of BMEC in the newborn rat model of hematogenous meningitis. ..
- RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEMNEAL BARMACK; Fiscal Year: 2003..abstract_text> ..
- MORPHOLOGIC BASIS FOR CENTRAL VESTIBULAR INHIBITIONGAY HOLSTEIN; Fiscal Year: 2002....
- Preclinical Testing of Interleukin-7 in PrimatesJan Storek; Fiscal Year: 2003..These results will be used for the design of clinical studies. ..
- The Ventral Striatal Network in Emotional ProcessingSuzanne Haber; Fiscal Year: 2002..This unique format, which was very successful at our last meeting, encourages free exchange of ideas to address the question "what is the role of the ventral striatal network in emotional processing? ..
- Trancellular Labeling from Defined Taste Receptor CellsThomas Finger; Fiscal Year: 2005..These mice also will be informative about the kinetics of protein handling, exocytosis and uptake by various cell types within the taste bud. ..
- Psychoneuroimmunology and Mind-Body MedicineJanice Kiecolt Glaser; Fiscal Year: 2005..Accordingly, a psychoneuroimmunology focus for these mechanistic studies will provide a way to clarify mechanisms while assessing clinical efficacy. ..
- Physical Activity, Aging and Immune FunctionJeffrey Woods; Fiscal Year: 2005..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
- LPH to VTA Neurotensin: Actions and Cocaine EffectsDANIEL ZAHM; Fiscal Year: 2004..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
- Exercise & influenza immunity:Psychoneuroendocrine ModelMarian Kohut; Fiscal Year: 2004..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
- CD1D REACTIVE T CELLS IN BONE MARROW TRANSPLANTATIONMark Exley; Fiscal Year: 2002..These preclinical studies are necessary to evaluate the hypothesis that human CD1d-reactive T cells have the therapeutic potential to selectively suppress acute GvH in the context of conventional BM and PBPC transplants for cancer. ..
- IMPACT OF AEROSOL CYCLOSPORINE IN LUNG TRANSPLANTATIONAdriana Zeevi; Fiscal Year: 2002..abstract_text> ..
- Fluoroquinolone Resistance in M. TuberculosisTimothy R Sterling; Fiscal Year: 2010..tuberculosis would clarify whether fluoroquinolones are indeed a viable option for the first-line treatment of tuberculosis, and how best to preserve their usefulness against tuberculosis. ..
- IL-12 as an Adjuvant for a Melanoma Peptide VaccineJeffrey Weber; Fiscal Year: 2003..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
- CTLA-4 Inhibition and Autoimmunity in MelanomaJeffrey Weber; Fiscal Year: 2008..abstract_text> ..
- Innate-like hepatic CD1d-reative NKT cells:Liver DiseaseMark Exley; Fiscal Year: 2008..I. on acute HCV infection in chimpanzees, as well as on liver immunology and on 'NKT' cells in general. ..
- IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMAJeffrey Weber; Fiscal Year: 2003....
- HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIAJeffrey Weber; Fiscal Year: 2003..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
- Dendritic Cell Vaccination During Lymphoid ReconstitutionJeffrey Weber; Fiscal Year: 2008..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..