phytohemagglutinins

Summary

Summary: Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.

Top Publications

  1. ncbi Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratory
    D Fulcher
    Department of Immunopathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    Immunol Cell Biol 77:559-64. 1999
  2. doi Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
    Y M Sjögren
    Department of Immunology, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    Clin Exp Allergy 39:1842-51. 2009
  3. pmc The PHA test reflects acquired T-cell mediated immunocompetence in birds
    Jose L Tella
    Department of Conservation Biology, Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain
    PLoS ONE 3:e3295. 2008
  4. pmc Evaluation of multitype mathematical models for CFSE-labeling experiment data
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
    Bull Math Biol 74:300-26. 2012
  5. ncbi Differential activation of macrophages in vitro by lectin Concanavalin A, Phytohemagglutinin and Wheat germ agglutinin: production and regulation of nitric oxide
    Varun Kesherwani
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Nitric Oxide 16:294-305. 2007
  6. ncbi Temporal dynamics of a T-cell mediated immune response in desert rodents
    Joëlle Goüy de Bellocq
    Mitrani Department of Desert Ecology, Jacob Blaustein Institutes for Desert Research, Ben Gurion University of the Negev, Sede Boqer Campus, 84990 Midreshet Ben Gurion, Israel
    Comp Biochem Physiol A Mol Integr Physiol 145:554-9. 2006
  7. ncbi Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
    S N Haber
    Department of Neurobiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 20:2369-82. 2000
  8. ncbi The perils and prospects of using phytohaemagglutinin in evolutionary ecology
    Malcolm W Kennedy
    Division of Ecology and Evolutionary Biology, Institute of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow, UK, G12 8QQ
    Trends Ecol Evol 21:653-5. 2006
  9. pmc Nestling immune response to phytohaemagglutinin is not heritable in collared flycatchers
    Natalia Pitala
    Bird Ecology Unit, Department of Biological and Environmental Sciences, PO Box 65, University of Helsinki, Helsinki 00014, Finland
    Biol Lett 3:418-21. 2007
  10. ncbi Immunosenescence and age-related susceptibility to influenza virus in Japanese quail
    Emma T Lavoie
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Dev Comp Immunol 31:407-14. 2007

Research Grants

  1. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
  2. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
  3. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
  4. Oral Transmission of HIV through Breastfeeding
    LOUISE contact KUHN; Fiscal Year: 2010
  5. Pathogenesis Of Essential Tremor: Cerebellar Metabolism
    Elan D Louis; Fiscal Year: 2010
  6. Treatment Options for Protease Inhibitor Exposed Children
    Louise Kuhn; Fiscal Year: 2010
  7. Safer Weaning Practices for HIV-infected women
    Louise Kuhn; Fiscal Year: 2010
  8. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan D Louis; Fiscal Year: 2010
  9. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2010
  10. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan Louis; Fiscal Year: 2009

Detail Information

Publications211 found, 100 shown here

  1. ncbi Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratory
    D Fulcher
    Department of Immunopathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    Immunol Cell Biol 77:559-64. 1999
    ....
  2. doi Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
    Y M Sjögren
    Department of Immunology, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    Clin Exp Allergy 39:1842-51. 2009
    ..Although animal and in vitro studies emphasize the role of the commensal gut microbiota in the development of the immune system, the influence of the gut microbiota on immune development in infants is unclear...
  3. pmc The PHA test reflects acquired T-cell mediated immunocompetence in birds
    Jose L Tella
    Department of Conservation Biology, Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain
    PLoS ONE 3:e3295. 2008
    ..However, mechanisms involved in local immunological and inflammatory processes provoked by PHA are poorly known, and its use and interpretation as an acquired immune response is currently debated...
  4. pmc Evaluation of multitype mathematical models for CFSE-labeling experiment data
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
    Bull Math Biol 74:300-26. 2012
    ..This model was then employed to understand the proliferation pattern of CD4+ and CD8+ T cells under polyclonal stimulation...
  5. ncbi Differential activation of macrophages in vitro by lectin Concanavalin A, Phytohemagglutinin and Wheat germ agglutinin: production and regulation of nitric oxide
    Varun Kesherwani
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Nitric Oxide 16:294-305. 2007
    ..The data also provides the relative measure and importance of different key signaling molecules in the regulation of NO production by macrophages on activation...
  6. ncbi Temporal dynamics of a T-cell mediated immune response in desert rodents
    Joëlle Goüy de Bellocq
    Mitrani Department of Desert Ecology, Jacob Blaustein Institutes for Desert Research, Ben Gurion University of the Negev, Sede Boqer Campus, 84990 Midreshet Ben Gurion, Israel
    Comp Biochem Physiol A Mol Integr Physiol 145:554-9. 2006
    ....
  7. ncbi Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
    S N Haber
    Department of Neurobiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 20:2369-82. 2000
    ..This anatomical arrangement creates a hierarchy of information flow and provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain...
  8. ncbi The perils and prospects of using phytohaemagglutinin in evolutionary ecology
    Malcolm W Kennedy
    Division of Ecology and Evolutionary Biology, Institute of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow, UK, G12 8QQ
    Trends Ecol Evol 21:653-5. 2006
    ....
  9. pmc Nestling immune response to phytohaemagglutinin is not heritable in collared flycatchers
    Natalia Pitala
    Bird Ecology Unit, Department of Biological and Environmental Sciences, PO Box 65, University of Helsinki, Helsinki 00014, Finland
    Biol Lett 3:418-21. 2007
    ..Our findings illustrate that full-sib comparisons of immunological measures may lead to an inflated estimate of heritability and also reveal a limited role of nestling PHA-response for sexual selection in this population...
  10. ncbi Immunosenescence and age-related susceptibility to influenza virus in Japanese quail
    Emma T Lavoie
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Dev Comp Immunol 31:407-14. 2007
    ..Our data demonstrate an age-related difference in immune function in Japanese quail that has similarities to age-related immunity in humans; younger and older animals had weaker immune responses compared to young adults...
  11. ncbi High interleukin-13 production by phytohaemagglutinin- and Der p 1-stimulated cord blood mononuclear cells is associated with the subsequent development of atopic dermatitis at the age of 3 years
    J Lange
    University Children s Hospital, Freiburg, Germany
    Clin Exp Allergy 33:1537-43. 2003
    ....
  12. ncbi Kidney bean lectin-induced Escherichia coli overgrowth in the small intestine is blocked by GNA, a mannose-specific lectin
    A Pusztai
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    J Appl Bacteriol 75:360-8. 1993
    ..Thus, GNA and perhaps other mannose-specific lectins, especially when used in a preventive mode, can be used to specifically block the proliferation of Type 1 E. coli in the small intestine...
  13. ncbi Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
    A N Akbar
    Department of Immunology, Royal Free Hospital School of Medicine, London, United Kingdom
    J Immunol 140:2171-8. 1988
    ..The recovery of virtually all alloantigen induced secondary proliferative response in the UCHL1+,CD45R- T cell population suggests that UCHL1 identifies a primed population of T cells which may include memory cells...
  14. ncbi An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow
    Camille Bonneaud
    Laboratoire de Parasitologie Evolutive CNRS UMR 7103, Universite Pierre et Marie Curie Paris 6, 7 quai St Bernard, bât A 7e étage, Case 237, Paris Cedex 05 75252, France
    Immunogenetics 57:782-9. 2005
    ..Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species...
  15. doi Epstein-Barr virus and cytomegalovirus are differentially associated with numbers of cytokine-producing cells and early atopy
    C Nilsson
    Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden
    Clin Exp Allergy 39:509-17. 2009
    ..We hypothesize that early exposure to EBV or CMV will affect the cytokine balance in the individual...
  16. doi High expression of alpha 2, 3-linked sialic acid residues is associated with the metastatic potential of human gastric cancer
    Feng Ling Wang
    Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China
    Cancer Detect Prev 32:437-43. 2009
    ..Herein, we measured the expression of alpha 2, 3-linked sialic acid residues by using a specific lectin as well as the potential of invasion and metastasis of gastric cancer was analyzed...
  17. pmc Direct targeting of cancer cells: a multiparameter approach
    Eileen L Heinrich
    Department of Biology and Center for Cancer and Developmental Biology, California State University Northridge, 18111 Nordhoff St, Northridge, CA 91330 8303, USA
    Acta Histochem 107:335-44. 2005
    ....
  18. ncbi Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population
    Rabia Hussain
    Department of Microbiology, The Aga Khan University, P O Box 3500, Stadium Road, Karachi, Pakistan
    J Immunol Methods 264:95-108. 2002
    ..015; CFP, p=0.05) and IL5 (PPD, p=0.05; CFP, p=0.015). Cytokine analysis in WB cultures is, therefore, able to discriminate between active tuberculosis infection and nondiseased healthy controls...
  19. pmc CD80/CD28 co-stimulation in human brucellosis
    P Skendros
    Clinical Immunology Unit, 2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Clin Exp Immunol 146:400-8. 2006
    ..We speculate that differential frequency of CD80(+) monocytes after PHA stimulation could serve as a qualitative parameter of disease status, related to the different clinical forms of chronic brucellosis...
  20. ncbi Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro
    Barbara Wirleitner
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Immunol Lett 100:159-63. 2005
    ....
  21. pmc Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children s Hospital, 3584 EA Utrecht, The Netherlands
    Clin Diagn Lab Immunol 10:133-9. 2003
    ..It will provide a more complete picture in differences between activated lymphocyte cytokine profiles from healthy individuals and those from patients with chronic inflammatory diseases...
  22. ncbi Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds
    X Y Ye
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT
    J Protein Chem 20:367-75. 2001
    ..It exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani. The lectin had low ribonuclease and negligible translation-inhibitory activities...
  23. ncbi Synaptic convergence of motor and somatosensory cortical afferents onto GABAergic interneurons in the rat striatum
    Sankari Ramanathan
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, OX1 3TH, United Kingdom
    J Neurosci 22:8158-69. 2002
    ..Furthermore, our findings suggest that the pattern of innervation of GABAergic interneurons by cortical afferents is different from the cortical innervation of spiny projection neurons...
  24. ncbi Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cells
    Christiana Winkler
    Biocenter, Division of Biological Chemistry, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Food Chem Toxicol 44:2003-7. 2006
    ..01 at 1 mM sodium sulfite and 50 mM sorbic acid). Data demonstrate a suppressive influence of sodium sulfite and sorbic acid on the activated Th1-type immune response...
  25. ncbi Diminished percentage of CD4+ T-lymphocytes expressing interleukine-2 receptor alpha in chronic brucellosis
    Panagiotis Skendros
    Clinical Immunology Unit, 2nd Department of Internal Medicine, Aristotle University, Konstantinoupoleos 49, 54642 Thessaloniki, Greece
    J Infect 54:192-7. 2007
    ..Simultaneously, CD3+, CD4+ and CD8+ T-lymphocytes subsets were measured...
  26. ncbi Isolation, cryopreservation, and mitogenesis of peripheral blood lymphocytes from chickens (Gallus domesticus) and wild herring gulls (Larus argentatus)
    E T Lavoie
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, 20742, USA
    Arch Environ Contam Toxicol 48:552-8. 2005
    ..The magnitudes of proliferation responses were similar to that for chicken lymphocytes. These methods have subsequently proven useful in ecotoxicology studies that involve species in remote locations...
  27. pmc Genetic diversity predicts pathogen resistance and cell-mediated immunocompetence in house finches
    Dana M Hawley
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Biol Lett 1:326-9. 2005
    ..Overall, our results underscore the importance of multilocus heterozygosity for individual pathogen resistance and immunity...
  28. pmc Antibody microarray analysis of inflammatory mediator release by human leukemia T-cells and human non small cell lung cancer cells
    Bradley H Garcia
    Thermo Fisher Scientific, 3747 N Meridian Road, Rockford, IL 61105, USA
    J Biomol Tech 18:245-51. 2007
    ..Our experiments clearly demonstrate the utility of antibody microarray analysis of cell-culture supernatants for the profiling of cellular inflammatory mediator release...
  29. ncbi Where are the parasites in the PHA response?
    Jeb P Owen
    Trends Ecol Evol 22:228-9. 2007
  30. ncbi Activation and up-regulation of phospholipase D expression by lipopolysaccharide in human peripheral T cells
    Eileen Jea Chien
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
    Chin J Physiol 47:203-9. 2004
    ..This indicated that LPS might enhance T cell adaptive immunity to resist Gram-negative bacterial infection...
  31. ncbi Involvement of P-gp in the process of apoptosis in peripheral blood mononuclear cells
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, Al Powstancow Wlkp 72, Poland
    Int Immunopharmacol 5:821-8. 2005
    ..Moreover these agents significantly increased the apoptosis induced by MTX, DEX, MP and COR. The results of this study suggest that P-gp is involved in the process of apoptosis in peripheral blood mononuclear cells...
  32. pmc Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent hosts
    R K Katial
    Department of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Clin Diagn Lab Immunol 5:78-81. 1998
    ..The mitogens used were concanavalin A, phytohemagglutinin, pokeweed mitogen, and Staphylococcus aureus Cowen. The results obtained provide a normal range for the production of these cytokines under specified conditions in vitro...
  33. ncbi Differential resource allocation in deer mice exposed to sin nombre virus
    Erin M Lehmer
    Department of Biology, Fort Lewis College, Durango, Colorado, USA
    Physiol Biochem Zool 80:514-21. 2007
    ..We propose that differences in resource allocation between males and females could result from inherent sex-based differences in parental investment...
  34. doi Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation
    Gozde Girgin
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Immunobiology 214:129-34. 2009
    ..The suppression of tryptophan degradation by propolis extracts may therefore be related with some of its beneficial health properties in humans...
  35. ncbi Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune function
    Manjula Reddy
    Department of Clinical Pharmacology, Centocor, 145 King of Prussia Road, Radnor, PA 19087 4517, USA
    J Immunol Methods 293:127-42. 2004
    ..This study defines the kinetics for both measures of T cell activation and provides a comprehensive review with various polyclonal activators that can serve as a reference for monitoring lymphocyte function in clinical study samples...
  36. ncbi In vitro nonspecific mitogenic response of T-cell subsets in acute and chronic brucellosis
    Sami Kinikli
    Department of Clinic Microbiology and Infection Diseases, Ministry of Health Ankara Hospital, Ankara, 06100 Sihhiye, Turkey
    Diagn Microbiol Infect Dis 52:229-33. 2005
    ....
  37. ncbi Major histocompatibility (B) complex and sex effects on the phytohaemagglutinin wattle response
    R L Taylor
    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824
    Anim Genet 18:343-50. 1987
    ..The developmental and early resolution phases of the PHA wattle response were influenced by sex while the late resolution phase was influenced by B genotype...
  38. ncbi Sialoglycoconjugate expression in primary colorectal cancer and metastatic lymph node tissues
    Yoshinori Inagaki
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 54:53-7. 2007
    ..To investigate the clinicopathological significance of sialylation in colorectal cancer, we performed histochemical analyses using sialic acid-binding lectins...
  39. ncbi Do dietary antioxidants alleviate the cost of immune activation? An experiment with greenfinches
    Peeter Hõrak
    Institute of Zoology and Hydrobiology, Tartu University, Vanemuise 46, 51014 Tartu, Estonia
    Am Nat 170:625-35. 2007
    ....
  40. ncbi Mitogen stimulation activates different signaling pathways in early- and late-divided T cells as revealed by cDNA microarray analysis
    Yufeng Li
    Graduate School of Biomedical Science, UT Health Science Center at Houston, Houston, TX 77030, USA
    Int J Mol Med 18:1127-39. 2006
    ..Because most tumors are infiltrated by lymphocytes, our studies indicate a novel approach to identify 'systemic biological responses' of T cells, which could determine the design, and optimization of effective tumor vaccines...
  41. pmc Differential gene expression profiles are dependent upon method of peripheral blood collection and RNA isolation
    Adam L Asare
    University of California, San Francisco, Immune Tolerance Network, 3 Bethesda Metro Suite 400, Bethesda, MD 20814, USA
    BMC Genomics 9:474. 2008
    ..Because the RNA purification steps could influence the total RNA pool, we examined the impact of RNA isolation, using the PAXgene or Tempus method, on gene expression profiles...
  42. ncbi Cell-mediated immunosenescence in birds
    Mark F Haussmann
    Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa 50011, USA
    Oecologia 145:270-5. 2005
    ..This link between declining immune function and survival may reflect differences in resource partitioning between species, and suggests that selection may act on investment in immune function to influence maximum life span...
  43. ncbi Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitis
    S L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
    Clin Exp Allergy 35:1557-64. 2005
    ..The purpose of this study was to determine the underlying immunological effects that are associated with these apparent clinical benefits...
  44. ncbi Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cells
    Eileen Jea Chien
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
    J Cell Biochem 99:292-304. 2006
    ..Progesterone might act directly through membrane specific nonclassical steroid receptors to cause immunomodulation and suppression of T-cell activation during pregnancy...
  45. ncbi [Activation of transcriptional factors stat5 and stat3 during human T-lymphocyte proliferation induced by different mitogenic stimuli]
    I A Karitskaia
    Tsitologiia 48:42-9. 2006
    ..Taken together, we report that the increased STAT5 phosphorylation can serve as a marker of T-lymphocyte entrance into IL-2-dependent stage of proliferation after T-cell activation by different mitogens...
  46. pmc Functional and molecular aspects of transient T cell unresponsiveness: role of selective interleukin-2 deficiency
    M D Köller
    Department Internal Medicine III, Division of Rheumatology, University of Vienna, Austria
    Clin Exp Immunol 132:225-31. 2003
    ..Despite the lack of proliferation, preactivated Tc phenotypically maintain an intermediate stage of activation. These data show how the same cell population can change its functional phenotype into a non-responder state...
  47. ncbi Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, ul Powst Wlkp 72, Poland
    Eur J Pharmacol 528:27-36. 2005
    ..Moreover, determination of C3435T and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with methotrexate and dexamethasone...
  48. pmc Specific stimulation of peripheral blood mononuclear cells from patients with acute myocarditis by peptide-bound flavin adenine dinucleotide (FAD), a naturally occurring autologous hapten
    G Cicek
    Institute for Biochemistry and Molecular Biology, University of Freiburg, Germany
    Clin Exp Immunol 132:366-70. 2003
    ..The results are consistent with a recall response by activated T cells, specific for the normally cryptic mitochondrial flavin-hapten, which may be liberated following cardiomyocyte destruction during the inflammation of the heart...
  49. ncbi Effect of lead exposure on the immune response of some occupationally exposed individuals
    Kamla Prasad Mishra
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, 226 014, Lucknow, India
    Toxicology 188:251-9. 2003
    ..In brief, this study demonstrates that lead can affect the immune response of the occupationally exposed individuals such as three-wheeler drivers, battery reconditioning workers and silver jewelery makers...
  50. ncbi Effects of perioperative recombinant human IFN-gamma (rHuIFN-gamma) application in vivo on T cell response
    A K Licht
    Department of Surgery, Ludwig Maximilians University Munich, Klinikum Grosshadern, 81377 Munich, Germany
    J Interferon Cytokine Res 23:149-54. 2003
    ..It improves immunoreactivity, as shown by elevated IL-2R levels. Elevated IL-2 and suppressed IL-4 levels indicate a shift toward a Th1-driven lymphocyte response...
  51. pmc Nuclear factor kappa B activation in human cord blood mononuclear cells
    Christian H Schroeter
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, U S A
    Pediatr Res 56:212-8. 2004
    ..Whether differential NF-kappaB activity in cord blood is related to the subsequent development of immune diseases requires further investigation...
  52. pmc Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alpha
    S M Dai
    Department of Bioregulation, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8512, Japan
    Ann Rheum Dis 63:1379-86. 2004
    ..To determine whether IL18 has any indirect effects on osteoclastogenesis mediated by T cells in RA synovium, and compare its effects with those of IL1 beta and TNF alpha...
  53. ncbi Inhibition of lymphocyte proliferation by prenylated flavones: artelastin as a potent inhibitor
    F Cerqueira
    Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto, Porto, Portugal
    Life Sci 73:2321-34. 2003
    ..However, it decreased the production of IFN-gamma, IL-2, IL-4 and IL-10 in ConA-stimulated splenocytes. Furthermore, artelastin had no effect on apoptosis of splenocytes...
  54. ncbi Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: a preliminary study
    Marta Kubera
    Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuro Endocrinol Lett 25:207-10. 2004
    ..The biological basis of treatment resistance in depression still remains unclear. Some studies suggest that there exists a relationship between a disturbance in the immune system and depression...
  55. ncbi Influence of carbohydrate and age on lymphocyte function following a marathon
    Dru A Henson
    Department of Biology, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 14:308-22. 2004
    ..This decrease occurred in both younger and older runners and was not influenced by carbohydrate...
  56. ncbi Dual effects of extracellular adherence protein from Staphylococcus aureus on peripheral blood mononuclear cells
    Axana Haggar
    Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Infect Dis 192:210-7. 2005
    ..Our results demonstrate novel immunomodulatory activities of Eap and identify potential mechanisms of action of intravenous IgG therapy in the treatment of S. aureus infections...
  57. ncbi In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101
    M Shohat
    Department of Dermatology and Cellular Immunology Unit, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Clin Exp Dermatol 30:432-4. 2005
    ..AS-101 inhibited the production of IL-10, IFNgamma, IL-2R and IL-5 in both PAA patients and controls, but there was a greater inhibitory effect in children with PAA...
  58. ncbi Effects of ribavirin on cytokine production of recall antigens and phytohemaglutinin-stimulated peripheral blood mononuclear cells. (Inhibitory effects of ribavirin on cytokine production)
    Silvia Sookoian
    Gastroenterology Section, Internal Medicine Department, Hospital JM Penna, GCBA
    Ann Hepatol 3:104-7. 2004
    ..To evaluate the effects of ribavirin on cytokine production of recall antigen and PHA-stimulated PBMC obtained from healthy individuals...
  59. ncbi The extracts from Nelumbo Nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells
    Chih Peng Liu
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Life Sci 75:699-716. 2004
    ....
  60. ncbi In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells
    C Winkler
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
    Planta Med 70:205-10. 2004
    ..The findings imply a potential application of the extracts as immunoregulators and would be in line with observations in patients using these extracts...
  61. ncbi Effect of the chlorpropamide and fructose-1,6-bisphosphate of soluble TNF receptor II levels
    Fernanda B Nunes
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Res 49:449-53. 2004
    ..In this way it acts as a powerful immunomodulatory agent...
  62. ncbi In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: a regulatory role for zinc
    Roberto Paganelli
    Department of Medicine, University, G D Annunzio, Chieti, Italy
    J Trace Elem Med Biol 17:11-5. 2003
    ..Our data are consistent with the hypothesis that Zn and Ni, as part of the heavy transition metals, may exchange roles in immune-mediated phenomena leading to expression of allergic contact dermatitis...
  63. ncbi Dendritic cell culture: a simple closed culture system using ficoll, monocytes, and a table-top centrifuge
    Christina M Celluzzi
    Blood and Cell Therapy Development Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855 2743, USA
    J Hematother Stem Cell Res 12:575-85. 2003
    ..The procedure is relatively fast (effective working time 5-6 h), does not impair monocyte function or induce substantial cell activation, and can be performed economically using equipment found in a typical blood banking environment...
  64. ncbi Cutaneous lymphocyte antigen expression on activated lymphocytes and its association with IL-12R (beta1 and beta2), IL-2Ralpha, and CXCR3
    Manjula Reddy
    Department of Clinical Pharmacology and Experimental Medicine, Centocor Inc, 145 King of Prussia Road, Radnor, PA 19087 4517, USA
    Cell Immunol 236:131-9. 2005
    ....
  65. pmc Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells
    K Schroecksnadel
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
    Clin Exp Immunol 134:53-6. 2003
    ..We conclude that in supernatants of stimulated peripheral blood mononuclear cells homocysteine is accumulating. T cell activation could be involved in the development of moderate hyperhomocysteinaemia...
  66. ncbi Gingipains in the culture supernatant of Porphyromonas gingivalis cleave CD4 and CD8 on human T cells
    Y Kitamura
    Department of Periodontology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Periodontal Res 37:464-8. 2002
    ..These results suggest that cysteine proteinases like gingipains released from P. gingivalis cleave T cell surface proteins and impede T cell function...
  67. ncbi Altered glucocorticoid immunoregulation in treatment resistant depression
    Moisés E Bauer
    Department of Microbiological Sciences, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, 90619 900 Porto Alegre, RS, Brazil
    Psychoneuroendocrinology 28:49-65. 2003
    ..Our data indicate that alterations in immune function and steroid regulation associated with depression are not related to elevated basal levels of cortisol and suggest that lymphocyte steroid resistance may be associated with TRP...
  68. ncbi Immunomodulatory effect of concentrated lime juice extract on activated human mononuclear cells
    M Gharagozloo
    Immunology Department, Medical School, Shiraz University of Medical Sciences, PO Box 71345-1798, Shiraz, Iran
    J Ethnopharmacol 77:85-90. 2001
    ..Considering these data, it can be concluded that the CLJ extract possesses immunomodulatory principles, which may mainly be due to the protein components of the extract...
  69. ncbi An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro
    A M Kamal
    Academic Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Clin Exp Allergy 31:1116-25. 2001
    ..Although it has been shown to inhibit "macroscopic" inflammatory processes in animal models, its direct effects on antigen-activated human T cells have not been studied...
  70. ncbi Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi
    Y C Kuo
    Laboratory of Biochemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Inflamm Res 50:73-82. 2001
    ..CONCLUSIONS: We hypothesize that the inhibitory mechanisms of emodin on activated T cells proliferation are related to the impairment of cytokine production, IL-2 mRNA level and [Ca2+]i in the cells...
  71. ncbi Inhibition of HIV infection by the cytokine midkine
    C Callebaut
    , URA 1930 CNRS, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France
    Virology 281:248-64. 2001
    ..The potent and distinct anti-HIV action of MK along with its enhanced expression in lymphocytes by various physiological stimuli suggests that MK is a cytokine that could be implicated in HIV-induced pathogenesis...
  72. ncbi Analysis of leukemia inhibitory factor, type 1 and type 2 cytokine production in patients with eosinophilic fasciitis
    J F Viallard
    , , Pessac, France
    J Rheumatol 28:75-80. 2001
    ..In this context, the simultaneous elevations of type 1 cytokines (IL-2 and IFN-gamma) and LIF production by the same cells may be an attempt by the immune system to limit the exacerbation of a type 2 dominant response...
  73. ncbi Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF
    I Kalousek
    Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Cell Mol Biol (Noisy-le-grand) 46:1163-71. 2000
    ....
  74. pmc Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
    BMC Immunol 7:29. 2006
    ....
  75. ncbi Molecular characterization of a new member of the immunoglobulin superfamily that potentially functions in T-cell activation and development
    D M Ruble
    Department of Animal Science, University of Minnesota, St Paul 55108, USA
    Immunogenetics 51:347-57. 2000
    ..Sequence similarities and expression patterns suggest that cTADS could be involved in cell recognition and adhesion, and/or peptide ligand binding...
  76. ncbi Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation
    Dirk Reinhold
    Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Int Immunopharmacol 6:1935-42. 2006
    ....
  77. ncbi Combination of monocyte-derived dendritic cells and activated T cells which express CD40 ligand: a new approach to cancer immunotherapy
    Takami Sato
    Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Immunol Immunother 53:53-61. 2004
    ..ATs also migrated toward the MIP-3beta. These results suggest a combination of DCs and ATs as a potentially effective therapeutic strategy...
  78. ncbi Regulatory effects of cytokines and cyclosporine A on peripheral blood mononuclear cells from stable multiple sclerosis patients
    C Guillen
    Departamento de Medicina,
    Immunopharmacol Immunotoxicol 21:527-49. 1999
    ..Cyclosporine A (CsA) inhibited the PR and the expression of activation antigens induced by PHA in PBMC from the three groups of subjects. This inhibitory effect of CsA have was enhanced by the addition of IFN-alpha...
  79. ncbi Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Immunol Lett 108:78-87. 2007
    ..Our findings may advance our understanding of the immunobiology of stem cells and facilitate the therapeutic application of cord blood stem cells...
  80. ncbi Upregulation of cyclin T1/CDK9 complexes during T cell activation
    J Garriga
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Oncogene 17:3093-102. 1998
    ....
  81. ncbi Artesunate and a major metabolite, dihydroartemisinin, diminish mitogen-induced lymphocyte proliferation and activation
    P Veerasubramanian
    Department of Immunology and Medicine, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 37:838-47. 2006
    ..Artesunate and DHART may diminish some PBMC responses to immunologic stimuli. Further work is warranted to define the mechanisms involved, and whether this affects malaria treatment...
  82. ncbi Redirection of cytokine production by lymphocytes from women with pre-term delivery by dydrogesterone
    Raj Raghupathy
    Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
    Am J Reprod Immunol 58:31-8. 2007
    ..To study the ability of dydrogesterone to modulate the production of pro-inflammatory and anti-inflammatory cytokines by lymphocytes from women undergoing pre-term delivery (PTD)...
  83. ncbi Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells
    E Zvetkova
    Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Sciences, Sofia
    Int Immunopharmacol 1:2143-50. 2001
    ..Green and black tea extracts displayed similar immunomodulatory properties in our in vitro system, whereas C. latifolium (L.) extracts seemed to be more effective in reducing neopterin formation in stimulated cells...
  84. ncbi A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds
    J Rachmilewitz
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Blood 98:3727-32. 2001
    ..These findings suggest a novel paradigm for immunoinhibition wherein negative regulators can finely tune, rather than inactivate, T-cell responses, and thereby skew the cytokine output of immunologic responses...
  85. ncbi Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006
    ..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
  86. ncbi Evaluation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCR
    In Soo Choi
    Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, South Korea
    FEMS Immunol Med Microbiol 34:119-26. 2002
    ..In alveolar macrophages and PBMC, however, IL-12 p 35 showed a higher expression than IL-12 p40. These results indicate that each cytokine has its own characteristic expression profile in different immune cells...
  87. ncbi ELISpot and ELISA analysis of spontaneous, mitogen-induced and antigen-specific cytokine production in cynomolgus and rhesus macaques
    Barbro Mäkitalo
    Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
    J Immunol Methods 270:85-97. 2002
    ..The establishment of reliable immunoassays for detection of macaque cytokines is of importance for future progress of research utilizing macaques as experimental animals...
  88. ncbi Detection of the genes induced in activated lymphocytes by modified differential display
    Hideo Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Japan
    J Investig Allergol Clin Immunol 12:86-90. 2002
    ..Differential display is a useful method for detection of inducible genes from a small amount of material and at various time points, although the homology of PCR primer influences the displayed genes...
  89. ncbi APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signaling
    Cosimo Tortorella
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Clinica Medica II, Policlinico, 70124, Bari, Italy
    Mech Ageing Dev 123:1389-402. 2002
    ..Taken together, the data outline the role of CD28 and IL-12/IL-15 signaling impairment in T cell proliferative deficiency during senescence...
  90. ncbi Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease
    Rosa Yañez
    Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energeticas, Medioambientales y Technologicas CIEMAT Marcelino Botín Foundation, Madrid, Spain
    Stem Cells 24:2582-91. 2006
    ..These findings constitute the first experimental proof that Ad-MSCs can efficiently control the GVHD associated with allogeneic hematopoietic transplantation, opening new perspectives for the clinical use of Ad-MSCs...
  91. ncbi Proliferative suppression and class I insufficiency on peripheral blood cells from hepatitis C patients overcome by exogenous cytokines or high-dose mitogen
    Pam Kimball
    Department of Surgery and Hepatology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia, USA
    Clin Immunol 103:317-23. 2002
    ..01) but not HLA antigen content (P = ns). The results show a biochemical and functional abnormality in PBLs from HCV+ individuals, which may contribute to HCV chronicity...
  92. ncbi Immunomodulatory effects of glatiramer acetate on superantigen- and mitogen-induced T-cell stimulation in vitro
    S Schmidt
    Department of Neurology, University of Bonn, Germany
    Mult Scler 8:307-9. 2002
    ....
  93. ncbi [The effect of mycophenolic acid on activation antigen expression and in vitro T lymphocytes proliferation in peripheral blood]
    Weiyan Zheng
    The Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China
    Zhonghua Nei Ke Za Zhi 41:329-32. 2002
    ..To explore the effect of mycophenolic acid (MPA) on activation and proliferation of T lymphocytes in vitro...
  94. ncbi Modulation of human T cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus
    A Schönemeyer
    Department of Molecular Parasitology and Institute of Medical Immunology, Charite Medical School, Humboldt University, Berlin, Germany
    J Immunol 167:3207-15. 2001
    ..Therefore, onchocystatin has the potential to contribute to a state of cellular hyporesponsiveness and is a possible pathogenicity factor essential for the persistence of O. volvulus within its human host...
  95. pmc Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients
    V Sanchez-Margalet
    Department of Clinical Biochemistry, Internal Medicine, Virgen Macarena University Hospital, Seville, Spain
    Clin Exp Immunol 129:119-24. 2002
    ..These results are consistent with the suggested role of leptin in modulating the immune response...
  96. ncbi Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritis
    K Miyake
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Rheumatology (Oxford) 41:518-24. 2002
    ..To clarify whether the interferon-gamma (IFN-gamma) gene (IFNG) is associated with the histological phenotype of lupus nephritis...
  97. ncbi Cytokine release by activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders
    Lev Shvidel
    Hematology Institute, Kaplan Medical Center, Rehovot, Israel
    Hematol J 3:32-7. 2002
    ..The pathogenesis of associated T-LGLL and autoimmune abnormalities is not clear. In this study we have investigated the role of cytokines in the development of immune complications in LGLL...
  98. ncbi Simian immunodeficiency viruses with defective nef genes show increased susceptibility to the noncytotoxic antiviral activity of CD8+ lymphocytes
    Doris Binninger-Schinzel
    Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany
    Virology 294:209-21. 2002
    ....
  99. pmc Respiratory syncytial virus fusion protein mediates inhibition of mitogen-induced T-cell proliferation by contact
    Jörg Schlender
    Max von Pettenkofer Institute and Gene Center, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    J Virol 76:1163-70. 2002
    ..However, a significant fraction of PBLs were delayed or defective in G0/G1 to S-phase transit...
  100. ncbi Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation
    T Hernandez-Caselles
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    J Immunol 151:3999-4012. 1993
    ..Our studies show that TNF might have unique and complex regulatory effects on growth and death of thymocyte populations in adult mice quite different from its effects on T cells in periphery...
  101. ncbi Mitogenic lectins bind to the antigen receptor on human lymphocytes
    O P Chilson
    Department of Biology, Washington University, St Louis, MO 63130
    Eur J Immunol 19:389-96. 1989
    ..on tonsil lymphocytes; II, III and IV are bound both leukoagglutinating (L)- and erythroagglutinating (E)-phytohemagglutinins from Phaseolus vulgaris (PHA). Pokeweed mitogen recognizes only II and III...

Research Grants114 found, 100 shown here

  1. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
  2. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
    ..These studies will advance our understanding of the anatomical substrates for pain sensation in the primate thalamus. ..
  3. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
  4. Oral Transmission of HIV through Breastfeeding
    LOUISE contact KUHN; Fiscal Year: 2010
    ..We will evaluate the role of these factors in reducing oral transmission via breastfeeding, preventing mucosal viral shedding and delaying disease progression in infected breast-fed infants. ..
  5. Pathogenesis Of Essential Tremor: Cerebellar Metabolism
    Elan D Louis; Fiscal Year: 2010
    ..Our tissue-based research will place us in unique a position to begin to address basic mechanistic questions about ET and may allow treating physicians to predict during life which subtype of ET a patient is likely to have. ..
  6. Treatment Options for Protease Inhibitor Exposed Children
    Louise Kuhn; Fiscal Year: 2010
    ....
  7. Safer Weaning Practices for HIV-infected women
    Louise Kuhn; Fiscal Year: 2010
    ..Our goal is to develop evidence-based nutrition counseling messages about safer practices for HIV-infected women and their infants around the time of weaning. ..
  8. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan D Louis; Fiscal Year: 2010
    ..This is a five-year competitive renewal in which we propose to firmly establish the links between this neurotoxin and ET. ..
  9. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2010
    ..Hence, the experiments will shed new light of mechanisms accounting for the co-morbidity of vertigo/dizziness and migraine symptoms in patients. ..
  10. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan Louis; Fiscal Year: 2009
    ..This is a five-year competitive renewal in which we propose to firmly establish the links between this neurotoxin and ET. ..
  11. Safer Weaning Practices for HIV-infected women
    Louise Kuhn; Fiscal Year: 2007
    ..Our goal is to develop evidence-based nutrition counseling messages about safer practices for HIV-infected women and their infants around the time of weaning. ..
  12. Pathogenesis Of Essential Tremor: Cerebellar Metabolism
    Elan Louis; Fiscal Year: 2007
    ..Knowledge of the pathological changes and neurochemical abnormality in ET is critical for the design of new therapies for ET. ..
  13. Clinical Relevance of Transient Nevirapine Resistance
    Louise Kuhn; Fiscal Year: 2007
    ....
  14. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan Louis; Fiscal Year: 2007
    ..Identification and understanding these toxicants is the first step in preventing a disease with only limited treatment options. ..
  15. Treatment Options for Protease Inhibitor Exposed Children
    Louise Kuhn; Fiscal Year: 2010
    ....
  16. Brainstem-Diencephalic Modulation of the Hippocampus
    ROBERT VERTES; Fiscal Year: 2006
    ..This work may have important implications for disorders of memory including Korsakoff's syndrome, diencephalic amnesia and Alzheimer's disease. ..
  17. HIV Protective Immunity and Perinatal Exposure
    Louise Kuhn; Fiscal Year: 2006
    ..abstract_text> ..
  18. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan Louis; Fiscal Year: 2003
    ..In addition, we will evaluate the associations between manganese, organic solvents and ET using a lifetime Occupational History. ..
  19. FINE STRUCTURE OF TSTT TERMINALS ON VMPO
    Arthur Craig; Fiscal Year: 2001
    ....
  20. CIRCUITRY CONTROLLING THE HIPPOCAMPAL THETA RHYTHM
    ROBERT VERTES; Fiscal Year: 2002
    ..This work may have important implications for conditions such as Alzheimer's that involve a loss of cholinergic neurons of the MS/DBv. ..
  21. STRUCTURAL BASIS OF CENTRAL HEARING MECHANISMS
    CRAIG HENKEL; Fiscal Year: 1990
    ..Improving assessment of these functions in hearing impaired individuals requires experiments such as the one proposed to increase our knowledge about the anatomical and physiological basis for neural processing of sound...
  22. STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
    CRAIG HENKEL; Fiscal Year: 2002
    ..Results should lead to a better understanding of the influence of experience on the development of these binaural sensory pathways. ..
  23. Immune Mechanisms of Severe RSV Disease- T Cell and Antibody Responses
    Frances Lee; Fiscal Year: 2007
    ..The goal of our studies is to provide insights in prevention and treatment of severe RSV disease in the elderly. ..
  24. Mechanisms of peanut (A. hypogaea) glycan adjuvanticity.
    Wayne Shreffler; Fiscal Year: 2007
    ..Better understanding of the mechanisms that contribute to the establishment of allergic responses may eventually be used in novel preventative or therapeutic strategies. ..
  25. Dendritic Cell Vaccination During Lymphoid Reconstitution
    Jeffrey Weber; Fiscal Year: 2007
    ..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
  26. Innate-like hepatic CD1d-reative NKT cells:Liver Disease
    Mark Exley; Fiscal Year: 2007
    ..I. on acute HCV infection in chimpanzees, as well as on liver immunology and on 'NKT' cells in general. ..
  27. Fluoroquinolone Resistance in M. Tuberculosis
    Timothy R Sterling; Fiscal Year: 2010
    ..tuberculosis would clarify whether fluoroquinolones are indeed a viable option for the first-line treatment of tuberculosis, and how best to preserve their usefulness against tuberculosis. ..
  28. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2010
    ..Our ultimate goal is to augment the ability of human immune cells to destroy tumor by altering the interaction of molecules that limit immunity in cancer patients like PD-1. ..
  29. Fluoroquinolone Resistance in M. Tuberculosis
    Timothy Sterling; Fiscal Year: 2009
    ..tuberculosis would clarify whether fluoroquinolones are indeed a viable option for the first-line treatment of tuberculosis, and how best to preserve their usefulness against tuberculosis. ..
  30. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2009
    ....
  31. Innate-like hepatic CD1d-reative NKT cells:Liver Disease
    Mark Exley; Fiscal Year: 2007
    ..I. on acute HCV infection in chimpanzees, as well as on liver immunology and on 'NKT' cells in general. ..
  32. CTLA-4 Inhibition and Autoimmunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2007
    ..abstract_text> ..
  33. RISK FACTORS FOR EXTRAPULMONARY TUBERCULOSIS
    Timothy Sterling; Fiscal Year: 2003
    ..The insights gained may also lead to an improved understanding of the mechanisms through which BCG protects against TB, and identify ways in which to develop a more effective TB vaccine. ..
  34. CD1D REACTIVE T CELLS IN BONE MARROW TRANSPLANTATION
    Mark Exley; Fiscal Year: 2002
    ..These preclinical studies are necessary to evaluate the hypothesis that human CD1d-reactive T cells have the therapeutic potential to selectively suppress acute GvH in the context of conventional BM and PBPC transplants for cancer. ..
  35. IL-12 as an Adjuvant for a Melanoma Peptide Vaccine
    Jeffrey Weber; Fiscal Year: 2003
    ..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
  36. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  37. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....