par 1 receptor

Summary

Summary: A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased PHOSPHOLIPASE C and increased PHOSPHOLIPASE A2.

Top Publications

  1. ncbi Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma
    D A Knight
    Asthma and Allergy Research Institute Inc, Nedlands, Western Australia, Australia
    J Allergy Clin Immunol 108:797-803. 2001
  2. pmc The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia
    Candice E Junge
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 100:13019-24. 2003
  3. ncbi PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    Adrienne Boire
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Cell 120:303-13. 2005
  4. pmc Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells
    Barbara Uzonyi
    Institute for Vascular Medicine aud Institute for Medical Statistics, Computer Sciences, and Documentation, Friedrich Schiller University, Bachstrasse 18, 07743 Jena, Germany
    Proc Natl Acad Sci U S A 103:6326-31. 2006
  5. pmc Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization
    May M Paing
    Department of Pharmacology, University of North Carolina at Chapel Hill, 1106 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7365 USA
    Mol Cell Biol 26:3231-42. 2006
  6. ncbi Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells
    Eric Camerer
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 277:16081-7. 2002
  7. ncbi beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation
    May M Paing
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 277:1292-300. 2002
  8. ncbi Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    Clemens Feistritzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 105:3178-84. 2005
  9. ncbi Protease-activated receptors: the role of cell-surface proteolysis in signalling
    Graeme S Cottrell
    Department of Surgery, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
    Essays Biochem 38:169-83. 2002
  10. ncbi Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts
    N M Schechter
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104 6142, USA
    J Cell Physiol 176:365-73. 1998

Research Grants

  1. THROMBIN RECEPTOR-G PROTEIN SIGNALING MECHANISMS
    Athan Kuliopulos; Fiscal Year: 2009
  2. Endothelial Myocyte Matrix in Cardiac Remodeling
    SURESH TYAGI; Fiscal Year: 2009
  3. Endothelial Myocyte Matrix in Cardiac Remodeling
    SURESH TYAGI; Fiscal Year: 2009
  4. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2010
  5. THROMBIN RECEPTOR-G PROTEIN SIGNALING MECHANISMS
    Athan Kuliopulos; Fiscal Year: 2010
  6. THROMBIN RECEPTOR-G PROTEIN SIGNALING MECHANISMS
    Athan Kuliopulos; Fiscal Year: 2007
  7. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2004
  8. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2005
  9. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2006
  10. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2007

Detail Information

Publications195 found, 100 shown here

  1. ncbi Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma
    D A Knight
    Asthma and Allergy Research Institute Inc, Nedlands, Western Australia, Australia
    J Allergy Clin Immunol 108:797-803. 2001
    ..PARs are activated by endogenous proteases, including thrombin (PAR-1, -3, and -4) and tryptase (PAR-2 and -4), both of which are present in inflamed airways...
  2. pmc The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia
    Candice E Junge
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 100:13019-24. 2003
    ....
  3. ncbi PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    Adrienne Boire
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Cell 120:303-13. 2005
    ..These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion...
  4. pmc Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells
    Barbara Uzonyi
    Institute for Vascular Medicine aud Institute for Medical Statistics, Computer Sciences, and Documentation, Friedrich Schiller University, Bachstrasse 18, 07743 Jena, Germany
    Proc Natl Acad Sci U S A 103:6326-31. 2006
    ..These data show that cysLT2-R activation results in a proinflammatory EC phenotype. Because LTD4 and thrombin are likely to be formed concomitantly in vivo, cysLT2-R and PAR-1 may cooperate to augment vascular injury...
  5. pmc Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization
    May M Paing
    Department of Pharmacology, University of North Carolina at Chapel Hill, 1106 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7365 USA
    Mol Cell Biol 26:3231-42. 2006
    ..Our findings establish a novel role for AP2 in direct regulation of PAR1 trafficking, a process critically important to the temporal and spatial aspects of thrombin signaling...
  6. ncbi Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells
    Eric Camerer
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 277:16081-7. 2002
    ..This information is critical for the design and interpretation of knockout mouse studies to probe the possible roles of Xa signaling in vivo...
  7. ncbi beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation
    May M Paing
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 277:1292-300. 2002
    ....
  8. ncbi Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    Clemens Feistritzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 105:3178-84. 2005
    ....
  9. ncbi Protease-activated receptors: the role of cell-surface proteolysis in signalling
    Graeme S Cottrell
    Department of Surgery, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
    Essays Biochem 38:169-83. 2002
    ..Therefore, selective antagonists or agonists of these receptors may be useful therapeutic agents for the treatment of human diseases...
  10. ncbi Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts
    N M Schechter
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104 6142, USA
    J Cell Physiol 176:365-73. 1998
    ..These results suggest that the proteases tryptase and chymase secreted from mast cells in skin may affect the behavior of surrounding cells by the hydrolysis of PARs expressed by these cells...
  11. ncbi Proteinase-activated receptors
    S R Macfarlane
    Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
    Pharmacol Rev 53:245-82. 2001
    ..The future identification of other PARs and their modes of activation are an important future direction for this expanding field of study...
  12. pmc 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
    Nicole C Kaneider
    Departments of Medicine and Biochemistry, Molecular Oncology Research Institute, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Immunol 8:1303-12. 2007
    ..Unexpectedly, we found that the protective effects of PAR1 required transactivation of PAR2 signaling pathways. Our results suggest therapeutics that selectively activate PAR1-PAR2 complexes may be beneficial in the treatment of sepsis...
  13. pmc Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion
    Michelle A Booden
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Mol Cell Biol 24:1990-9. 2004
    ..Thus, our results reveal that a novel alteration in trafficking of activated PAR1 causes persistent signaling and, in addition to other processes and proteins, contributes to breast carcinoma cell invasion...
  14. pmc Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis
    David C J Howell
    Centre for Respiratory Research, University College London, The Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
    Am J Pathol 166:1353-65. 2005
    ....
  15. ncbi The cytoprotective protein C pathway
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine MEM 180, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Blood 109:3161-72. 2007
    ....
  16. ncbi Thrombin receptor expression is upregulated in prostate cancer
    Varsha Kaushal
    Department of Internal Medicine, University of Arkansas for Medical Sciences, and Division of Hematology Oncology, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Prostate 66:273-82. 2006
    ..Aberrant expression of protease-activated receptors (PARs) has been associated with increased angiogenesis, tumor growth, and metastasis of various cancers. We assessed the status of PAR1 expression in prostate cancer...
  17. pmc Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis
    Jessica S Blackburn
    Department of Biochemistry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Pathol 173:1736-46. 2008
    ....
  18. ncbi Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 36:676-85. 2005
    ..Conversely, the significance of PAR-2 up-regulation in both benign and malignant melanocytic lesions requires further research...
  19. ncbi PAR1 cleavage and signaling in response to activated protein C and thrombin
    Matthew J Ludeman
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    J Biol Chem 280:13122-8. 2005
    ..Although consistent with reports that sufficiently high concentrations of APC can cleave and activate PAR1 in culture, our data suggest that a significant physiological role for PAR1 activation by APC is unlikely...
  20. pmc Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways
    Xiaoling Deng
    Centre for Respiratory Research, University College London, London WC1E 6JJ, United Kingdom
    Mol Biol Cell 19:2520-33. 2008
    ....
  21. pmc Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA
    Gabriel J Villares
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:9078-86. 2008
    ..We propose that siRNA incorporated into DOPC nanoparticles could be delivered systemically and used as a new modality for melanoma treatment...
  22. ncbi The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways
    C B Martin
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina NC 27599-7295, USA
    Oncogene 20:1953-63. 2001
    ..Taken together, these observations suggest that PAR-1 growth transformation is mediated, in part, by activation of RhoA...
  23. ncbi Cdc42 regulates the restoration of endothelial barrier function
    Panos Kouklis
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Ill, USA
    Circ Res 94:159-66. 2004
    ..The delayed activation of Cdc42 represents a negative-feedback mechanism that signals AJ reassembly after the increase in endothelial permeability induced by inflammatory mediators such as thrombin...
  24. ncbi The pattern of expression of protease-activated receptors (PARs) during early trophoblast development
    Sharona Cohen Even-Ram
    Department of Oncology, Pathology, Hadassah University Hospital, Jerusalem, Israel
    J Pathol 200:47-52. 2003
    ..Together, our data suggest the involvement of PAR1 and PAR3 in restricted and unrestricted pathological trophoblast invasion...
  25. ncbi Role and regulation of the thrombin receptor (PAR-1) in human melanoma
    Carmen Tellez
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 22:3130-7. 2003
    ....
  26. ncbi Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
    P J O'Brien
    Departments of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:13502-9. 2000
    ..Such transactivation may limit the effectiveness of PAR1 antagonists, which compete with the tethered ligand domain rather than preventing PAR1 cleavage...
  27. ncbi The agonist of the protease-activated receptor-1 (PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells
    T Arisato
    Department of Laboratory and Molecular Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Cell Mol Life Sci 60:1716-24. 2003
    ..Thus, our data show that thrombin caused VEGF release via PARI activation in a manner dependent on [Ca2+]i and p44/42 downstream from the receptor activation...
  28. pmc Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer
    Anika Agarwal
    Molecular Oncology Research Institute, Tufts Medical Center, Box 7510, Boston, MA 02111, USA
    Mol Cancer Ther 7:2746-57. 2008
    ..These data provide an in vivo proof-of-concept that targeting the metalloprotease-PAR1 signaling system may be a novel therapeutic approach in the treatment of ovarian cancer...
  29. ncbi Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors
    Susan R Wilson
    School of Pharmacy, Medical Biology Centre, Queens University Belfast, 97 Lisburn Road, Belfast, United Kingdom
    Prostate 60:168-74. 2004
    ..Protease-activated receptors (PARs) have previously been shown to be involved in pathways of MMP upregulation by tumor cells...
  30. pmc Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cells
    Tetsuzo Nakayama
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Br J Pharmacol 138:121-30. 2003
    ..05) attenuated by the preceding stimulation with thrombin but not trypsin. 5 In conclusion, trypsin cleaved PAR1 but did not activate it in the endothelial cells. Moreover, the trypsin-cleaved PAR1 was no longer responsive to thrombin...
  31. ncbi Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1
    Joseph N McLaughlin
    Department of Pharmacology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 280:25048-59. 2005
    ..This model provides an estimate that peptide activation alters receptor/G protein binding to favor Galpha(q) activation over Galpha(12/13) by approximately 800-fold...
  32. pmc Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells
    Kristina K Hansen
    Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    Immunology 112:183-90. 2004
    ....
  33. ncbi Phospholipid metabolite production in human urothelial cells after protease-activated receptor cleavage
    Alice Rickard
    Department of Pathology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Physiol Renal Physiol 283:F944-51. 2002
    ..Thus stimulation of PAR-1 or PAR-2 on HUR leads to iPLA(2)-catalyzed phospholipid hydrolysis, resulting in the production of metabolites that may mediate inflammation or provide cytoprotection to the bladder...
  34. ncbi A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization
    May M Paing
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    J Biol Chem 279:21938-47. 2004
    ..This study is the first to describe a function for a tyrosine-based motif, YXX, in GPCR internalization and reveal novel complexities in the regulation of GPCR trafficking...
  35. ncbi Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism
    Steven Swift
    Molecular Oncology Research Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 281:4109-16. 2006
    ..This "7-8-1" interaction network was found to be prevalent in G protein-coupled receptors involved in endothelial signaling and angiogenesis...
  36. ncbi Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells
    Arshad Rahman
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612 7343, USA
    Circ Res 91:398-405. 2002
    ..These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt...
  37. ncbi von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation
    Sandra Turcotte
    Laboratoire de Medecine Moleculaire, Hopital Sainte Justine, Universite du Quebec a Montreal, Montreal, Quebec
    Int J Cancer 112:777-86. 2004
    ..Together, these results demonstrate that thrombin induces both pVHL expression via PAR1/RhoA activation as well as the stimulation of renal cancer cell invasion suggesting a role for thrombin in tumor invasion...
  38. ncbi Characterization and functional activity of thrombin receptors in the human lens
    Colin James
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Invest Ophthalmol Vis Sci 46:925-32. 2005
    ..To investigate the expression of thrombin receptors in the human lens, the activation of downstream signaling pathways, and the ability of thrombin to regulate lens cell growth...
  39. ncbi Protease-activated receptor stimulation activates a Ca2+-independent phospholipase A2 in bladder microvascular endothelial cells
    Alice Rickard
    Dept of Pathology, Saint Louis Univ School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Renal Physiol 288:F714-21. 2005
    ....
  40. ncbi Human protease-activated receptor 1 expression in malignant epithelia: a role in invasiveness
    Yong Jun Yin
    Department of Oncology, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel
    Arterioscler Thromb Vasc Biol 23:940-4. 2003
    ..PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands...
  41. ncbi Protease-activated receptor 1: a role in prostate cancer metastasis
    Ta Chun Yuan
    Department of Biochemistry, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Clin Prostate Cancer 3:189-91. 2004
    ....
  42. pmc Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder
    Michael R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania, USA
    Am J Pathol 162:907-23. 2003
    ..It is timely to understand the role of tryptase signaling and PARs in the context of bladder biology...
  43. pmc A role for proteinase-activated receptor-1 in inflammatory bowel diseases
    Nathalie Vergnolle
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 114:1444-56. 2004
    ....
  44. ncbi Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells
    Hua Tang
    Department of Biochemistry, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Blood 105:1977-85. 2005
    ..Since TGF-beta plays a crucial role in the resolution phase of angiogenesis, the down-regulation of TGF-beta signaling by thrombin-PAR1 pathway may provide a new insight into the mechanism of the proangiogenic effect of thrombin...
  45. ncbi Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    Tong Cheng
    Frank P Smith Neurosurgical Research Laboratory, Department of Neurosurgery and Center for Aging and Developmental Biology, Division of Neurovascular Biology, University of Rochester Medical Center, Rochester, New York, USA
    Nat Med 9:338-42. 2003
    ..9). Moreover, the in vivo neuroprotective effects of low-dose mouse APC seemed to be independent of its anti-coagulant activity. Thus, APC protects the brain from ischemic injury by acting directly on brain cells...
  46. ncbi Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples
    Sorina Grisaru-Granovsky
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Int J Cancer 113:372-8. 2005
    ..Altogether our data suggest that hPar1 and FAK cooperate to promote ovarian cancer malignancy...
  47. ncbi Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells
    Hiroshi Kataoka
    Cardiovascular Research Institute and Department of Medicine and Celluar and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    Blood 102:3224-31. 2003
    ..These receptors serve at least partially redundant roles in endothelial cells in vitro and in vivo and together are necessary for the thrombin responses measured...
  48. ncbi Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice
    Christopher D Major
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19477 0776, USA
    Arterioscler Thromb Vasc Biol 23:931-9. 2003
    ....
  49. pmc An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins
    Anuradha Gullapalli
    Department of Pharmacology, University of North Carolina at Chapel Hill, NC 27599 7365, USA
    Mol Biol Cell 17:1228-38. 2006
    ..Together, our findings establish an essential role for endogenous SNX1 in sorting activated PAR1 to a distinct lysosomal degradative pathway that is independent of retromer, Hrs, and Tsg101...
  50. ncbi New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology
    C Patterson
    Program in Molecular Cardiology and Department of Medicine, Lineberger Comprehensive Cancer Center and Center for Thrombosis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7075, USA
    Circ Res 88:987-97. 2001
    ..In this review, we examine the activation of protease-activated receptors by thrombin, the downstream signaling events mediated by these receptors, and the physiological role of thrombin in vascular cells and vascular disease...
  51. ncbi Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries
    J R Hamilton
    Department of Pharmacology, University of Melbourne, Victoria, Australia
    J Cardiovasc Pharmacol 38:108-19. 2001
    ..We conclude that human pulmonary arteries express PAR1, PAR2, and PAR4, but that only PAR1, or a PAR1-like receptor, is coupled to endothelium-dependent relaxation...
  52. pmc Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues
    M R D'Andrea
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Am J Pathol 158:2031-41. 2001
    ..PAR-1 and PAR-2 in the cells forming the tumor microenvironment suggest that these receptors mediate the signaling of secreted thrombin and trypsin in the processes of cellular metastasis...
  53. ncbi Regulated shedding of PAR1 N-terminal exodomain from endothelial cells
    Matthew J Ludeman
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    J Biol Chem 279:18592-9. 2004
    ..Nonetheless, regulated shedding of G protein-coupled receptors represents a new mechanism by which signaling by this important class of receptors might be modulated...
  54. ncbi Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha
    L Chi
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160-7317, USA
    J Interferon Cytokine Res 21:231-40. 2001
    ..The results demonstrate significant potentiation of PAR-induced signaling by LPS and TNF-alpha and indicate the potential cooperation of proteases and inflammatory stimuli in amplifying vascular inflammation...
  55. pmc Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion
    P Arora
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Oncogene 27:4434-45. 2008
    ..These studies reveal a critical role for PAR1, a receptor activated by tumor-generated proteases, in hyperactivation of ErbB signaling that promotes breast carcinoma cell invasion...
  56. ncbi Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin
    S C Even-Ram
    Departments of Oncology and Pharmacology at the Hadassah Hebrew University Hospital, Jerusalem 91120, Israel, The Department of Hematology, Medical Center, Tel Aviv 64239, Israel
    J Biol Chem 276:10952-62. 2001
    ..We propose that the activation of PAR1 may lead to a novel cooperation with the alpha(v)beta(5) integrin that supports tumor cell invasion...
  57. ncbi Protease-activated receptors in inflammation, neuronal signaling and pain
    N Vergnolle
    Mucosal Inflammation Research Group, Dept of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Alberta, T2N 4N1, Calgary, Canada
    Trends Pharmacol Sci 22:146-52. 2001
    ..Thus, the list of potential roles for PARs has lengthened considerably and their physiological course of action might be much broader than initially anticipated...
  58. ncbi Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice
    S M Vogel
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Physiol Genomics 4:137-145. 2000
    ..The results indicate that the PAR-1 receptor is critical in mediating the permeability-increasing and vasoconstrictor effects of thrombin in pulmonary microvessels...
  59. ncbi Review article: proteinase-activated receptors - novel signals for gastrointestinal pathophysiology
    N Vergnolle
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada
    Aliment Pharmacol Ther 14:257-66. 2000
    ..Nonetheless, the use of PAR agonists has already highlighted new potential functions for proteinases in the gastrointestinal tract, thus the control of PAR activation might represent a promising therapeutic target...
  60. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
  61. pmc Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
    M A Cunningham
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 3168 Victoria, Australia
    J Exp Med 191:455-62. 2000
    ..These results indicate that activation of PAR-1 by thrombin or TRAP amplifies crescentic GN. Thus, in addition to its procoagulant role, thrombin has proinflammatory, PAR-1-dependent effects that augment inflammatory renal injury...
  62. ncbi PAR1 thrombin receptor-G protein interactions. Separation of binding and coupling determinants in the galpha subunit
    S Swift
    Molecular Cardiology Research Institute, Division of Hematology, New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 275:2627-35. 2000
    ....
  63. pmc How the protease thrombin talks to cells
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    Proc Natl Acad Sci U S A 96:11023-7. 1999
    ..PAR2 is activated by trypsin and by trypsin-like proteases but not by thrombin. Recent studies with knockout mice, receptor-activating peptides, and blocking antibodies are beginning to define the role of these receptors in vivo...
  64. ncbi Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy
    A Kuliopulos
    Molecular Cardiology Research Institute, Division of Hematology Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
    Biochemistry 38:4572-85. 1999
    ..Truncation of the wild-type receptor at the C-terminal plasmin-cleavage sites removes the N-terminal tethered ligand or preligand, thereby providing an effective pathway for PAR1 desensitization in vivo...
  65. pmc Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase
    Hiroyuki Suzuki
    Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
    Hypertension 53:182-8. 2009
    ....
  66. pmc Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism
    L de Garavilla
    The R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
    Br J Pharmacol 133:975-87. 2001
    ..In intact tissues, neurogenic mechanisms are predominantly responsible for PAR1-induced oedema...
  67. ncbi A role for thrombin receptor signaling in endothelial cells during embryonic development
    C T Griffin
    Cardiovascular Research Institute, University of California at San Francisco UCSF, San Francisco, California 94143
    Science 293:1666-70. 2001
    ....
  68. ncbi Thrombin/thrombin receptor (PAR-1)-mediated induction of IL-8 and VEGF expression in prostate cancer cells
    Jian Liu
    University of Rostock, Institute of Clinical Chemistry and Laboratory Medicine, Ernst Heydemann Str 6, D 18057 Rostock, Germany
    Biochem Biophys Res Commun 343:183-9. 2006
    ..The results suggest that the thrombin/PAR-1 system upregulates cytokines in prostate cancer cells which in turn may contribute to the progression of prostate cancer...
  69. ncbi Protease-activated receptors: sentries for inflammation?
    T M Cocks
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Trends Pharmacol Sci 21:103-8. 2000
    ..In this article, the ways in which the distribution and function of PARs could be harnessed by pharmacologists as novel anti-inflammatory therapeutic strategies are discussed...
  70. pmc Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
    M L Kahn
    Cardiovascular Research Institute and Daiichi Research Center, University of California San Francisco, San Francisco, California 94143 0130, USA
    J Clin Invest 103:879-87. 1999
    ..These observations suggest that PAR1 and PAR4 account for most, if not all, thrombin signaling in platelets and that antagonists that block these receptors might be useful antithrombotic agents...
  71. ncbi Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression
    Zaidoun Salah
    Department of Oncology, Hadassah Hebrew University Hospital, P O Box 12000, Jerusalem 91120, Israel
    Mol Cancer Res 5:229-40. 2007
    ..We conclude that whereas PAR1 gene expression correlates with tumor progression, its neutralization effectively initiates an apoptotic pathway leading at least in part to significantly reduced tumor formation...
  72. ncbi Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
    Nithiananthan Asokananthan
    Division of Inflammation and Infectious Diseases, Department of Microbiology, Asthma and Allergy Research Institute, University of Western Australia, Nedlands, Western Australia, Australia
    J Immunol 168:3577-85. 2002
    ..Combined, these data suggest an important role for PAR in the modulation of inflammation in the lung...
  73. pmc Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides
    Lidija Covic
    Molecular Cardiology Research Institute, Division of Hematology Oncology, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:643-8. 2002
    ..Construction of such peptide-lipid conjugates constitutes a new molecular strategy for the development of therapeutics targeted to the receptor-effector interface...
  74. pmc Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
    Joseph N McLaughlin
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:5662-7. 2007
    ..Because PAR3 is a critical determinant of PAR1 function, targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation...
  75. ncbi Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation
    Chii Heui Chen
    Department of Pharmacology, Cardiovascular Biology Center, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill 27599 7365, USA
    J Biol Chem 279:10020-31. 2004
    ..These findings reveal a new level of complexity in the regulation of protease-activated GPCR signaling...
  76. ncbi Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells
    Dionne R Morris
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7365, USA
    Cancer Res 66:307-14. 2006
    ....
  77. ncbi Human corneal epithelial cells express functional PAR-1 and PAR-2
    Roland Lang
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 44:99-105. 2003
    ..The objective of this study was to examine whether HCECs express functional proteinase-activated receptor (PAR)-1 and -2 and evaluate the effects of receptor activation on corneal epithelial cell proinflammatory cytokine production...
  78. ncbi Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells
    Tadamichi Shimizu
    Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Chem 279:13729-37. 2004
    ..Taken together, these results suggest that MIF contributes to the inflammatory phase of the wound healing process in concert with thrombin and FXa via PAR-1 and PAR-2...
  79. doi Proteinase-activated receptor-1 (PAR(1)) and PAR(2) but not PAR(4) mediate contraction in human and guinea-pig gallbladders
    M C Lee
    Department of Surgery, Graduate Institute of Medicine, Tzu Chi University and Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Neurogastroenterol Motil 20:385-91. 2008
    ..PAR(1) and PAR(2) may play important roles in the control of both human and guinea-pig gallbladder motility...
  80. ncbi Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4
    Todd M Quinton
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:18434-9. 2004
    ..Finally, a protease-resistant recombinant PAR-4 was refractory to activation by plasmin. We conclude that plasmin induces platelet aggregation primarily through slow cleavage of PAR-4...
  81. ncbi Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4
    Rithwik Ramachandran
    Division of Cardiovascular and Respiratory Studies, Postgraduate Medical Institute of the University of Hull, Hull York Medical Schoo, East Yorkshire, UK
    Am J Physiol Lung Cell Mol Physiol 292:L788-98. 2007
    ..These findings point to an important mechanism, whereby cellular responses to thrombin and cathepsin-G can be modified during an inflammatory response...
  82. ncbi Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cells
    Rebecca A Houliston
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, Royal College Street, London, UK
    Thromb Haemost 88:321-8. 2002
    ..These results demonstrate that regulation of COX-2 induction is an important functional response of HUVEC to PAR activation and suggest that PARs promote sustained upregulation of prostanoid production in human endothelium...
  83. doi The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine
    Magnus Grenegård
    Department of Medicine and Health, Division of Drug Research, Division of Clinical Chemistry, Cardiovascular Inflammation Research Center, Linkoping University, Linköping SE 581 85 Sweden
    J Biol Chem 283:18493-504. 2008
    ..These results suggest a new mechanism that has ATP as a key element and circumvents the action of aspirin on epinephrine-facilitated PAR4-mediated platelet activation...
  84. ncbi Actin polymerisation regulates thrombin-evoked Ca(2+) signalling after activation of PAR-4 but not PAR-1 in human platelets
    Matthew T Harper
    Department of Physiology, University of Cambridge, Downing Street, Cambridge, UK
    Platelets 17:134-42. 2006
    ..These data suggest that Cyt D prevents the internalisation of PAR-4, which may lead to prolonged signalling from this receptor. This may mask a direct effect of Cyt D on the activation of SOCE after the activation of PAR-4...
  85. ncbi Protease-activated receptor 4-mediated Ca2+ signaling in mouse lung alveolar epithelial cells
    Seijitsu Ando
    Department of Pharmacology, Kansai Medical University, 10 15, Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Life Sci 81:794-802. 2007
    ..The latter mechanism probably contributed to the longer responsiveness of PAR4 stimulation...
  86. ncbi Protease-activated receptor-induced Akt activation--regulation and possible function
    J C Reséndiz
    Wihuri Research Institute, Kalliolinnantie 4, Helsinki, Finland
    J Thromb Haemost 5:2484-93. 2007
    ..Akt activation is dependent on its phosphorylation at Thr308 and Ser473. The mechanism by which thrombin induces Akt phosphorylation is controversial, as is the role of Akt in platelet function...
  87. ncbi Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions
    Matthew L Bilodeau
    Department of Pharmacology, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 442 Robinson Research Building, Nashville, TN 37232 6600, USA
    J Pharmacol Exp Ther 322:778-88. 2007
    ..Specifically, PAR4 inhibition depends on the regulation of both calcium mobilization and dense granule release, and PAR1 inhibition depends predominantly on the regulation of dense granule release...
  88. ncbi Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II
    Monique David-Dufilho
    Department of Signalisation Cellulaire et Atherosclerose Precoce, Universite Paris 6 CNRS, Paris 75014, France
    J Biol Chem 280:35999-6006. 2005
    ..This signaling may contribute to thrombomodulin function in thrombosis, inflammation, and atherosclerosis...
  89. ncbi Thrombin-stimulated proliferation of cultured human synovial fibroblasts through proteolytic activation of proteinase-activated receptor-1
    Ikue Furuhashi
    Pharmacological Research Department, Research Laboratory, Minophagen Pharmaceutical Co Ltd, 2 2 3 Komatsubara, Zama, Kanagawa, Japan
    J Pharmacol Sci 108:104-11. 2008
    ....
  90. pmc Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro
    Michele Tognetto
    Department of Experimental and Clinical Medicine, Pharmacology Unit, University of Ferrara, S Anna Hospital, via Fossato di Mortara 19, 44100 Ferrara, Italy
    Br J Pharmacol 139:21-7. 2003
    ..5. In agreement with the motor function data immunohistochemistry showed specific staining patterns for PAR-1 in the human renal artery. 6. Combined, these studies would suggest a possible role for PAR-1 in renal vascular homeostasis...
  91. ncbi Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors
    Yaowanuj Kirilak
    School of Surgery and Pathology Orthopaedics, The University of Western Australia, Crawley WA 6009, Australia
    Int J Mol Med 17:551-8. 2006
    ..Together, these data demonstrate that FS supports both the migration and proliferation of human chondrocytes. We propose that these effects are mediated, at least in part, via thrombin-induced PAR-1 signalling in human chondrocytes...
  92. pmc Effects of inhaled thrombin receptor agonists in mice
    James D Moffatt
    Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, Kings College London, 5th Floor Hodgkin Building, Guy s Campus, London SE1 9RT
    Br J Pharmacol 143:269-75. 2004
    ..In conclusion, exogenous thrombin has only a modest acute inflammatory action in the lung that appears to be mediated by PAR(4) and involve release of TNF-alpha from an unknown source...
  93. ncbi Differential Ca(2+)responses induced by thrombin and thrombin-receptor agonist peptides in HSY-EA1 cells
    Akihiko Tanimura
    Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Cell Biol Int 27:1017-23. 2003
    ..These observations indicate that thrombin disarms PAR-1 from further proteolytic activation, but leaves the receptor responsive for non-tethered ligands...
  94. ncbi The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes
    Hong Wang
    Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Institut fur Neurobiochemie, Magdeburg, Germany
    J Neurochem 84:1349-57. 2003
    ..From these data we conclude that PAR-1 uses Ca2+- and PKC-dependent Pyk2 to activate Src, thereby leading to ERK1/2 activation, which predominantly recruits Grb2 in rat astrocytes...
  95. ncbi [The role of PAR family receptors in activation of mast cells in the norm and in acute inflammation in rats]
    E V Kiseleva
    M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia
    Ross Fiziol Zh Im I M Sechenova 87:1527-33. 2001
    ..Acceleration of the mast cell mediator secretion by the Xa factor and PAR-2 agonist, was revealed. An increase in the mast cell release induced by thrombin and TRAP-6 was shown in the acute peritonitis model...
  96. ncbi Receptors of the PAR family as a link between blood coagulation and inflammation
    T N Dugina
    Department of Human and Animal Physiology, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 67:65-74. 2002
    ..The presence of PAR receptors on mast cells is responsible for their reactivity to thrombin and factor Xa and defines their contribution to the association of inflammation and blood clotting processes...
  97. ncbi Participation of protease-activated receptor-1 in thrombin-induced microglial activation
    Zhiming Suo
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    J Neurochem 80:655-66. 2002
    ..In addition, strategies aimed at blocking thrombin signaling through PAR1 may be therapeutically valuable for diseases associated with cerebral vascular damage and significant inflammation with microglial activation...
  98. ncbi Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas
    Enjing Jin
    Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, Graduate School of Medicine, Kawasaki, Japan
    Cancer 97:703-13. 2003
    ..Cell growth can be induced via elicitation of protease-activated receptors (PAR) with serine proteases such as thrombin and trypsin...
  99. pmc Mechanisms of action of proteinase-activated receptor agonists on human platelets
    Ada W Y Chung
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Br J Pharmacol 135:1123-32. 2002
    ..11. Thus, the mechanisms of PAR1 and 4-induced platelet aggregation are distinct and depend differentially on their ability to interact with pathways of aggregation, along with the subsequent activation of GPIIb/IIIa receptors...
  100. ncbi Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling
    Soochong Kim
    Department of Physiology and the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 99:3629-36. 2002
    ....
  101. pmc PARticipation in inflammation
    Shaun R Coughlin
    Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    J Clin Invest 111:25-7. 2003

Research Grants103 found, 100 shown here

  1. THROMBIN RECEPTOR-G PROTEIN SIGNALING MECHANISMS
    Athan Kuliopulos; Fiscal Year: 2009
    ....
  2. Endothelial Myocyte Matrix in Cardiac Remodeling
    SURESH TYAGI; Fiscal Year: 2009
    ....
  3. Endothelial Myocyte Matrix in Cardiac Remodeling
    SURESH TYAGI; Fiscal Year: 2009
    ....
  4. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2010
    ....
  5. THROMBIN RECEPTOR-G PROTEIN SIGNALING MECHANISMS
    Athan Kuliopulos; Fiscal Year: 2010
    ....
  6. THROMBIN RECEPTOR-G PROTEIN SIGNALING MECHANISMS
    Athan Kuliopulos; Fiscal Year: 2007
    ....
  7. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2004
    ..abstract_text> ..
  8. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2005
    ..abstract_text> ..
  9. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2006
    ..abstract_text> ..
  10. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2007
    ..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  11. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2006
    ..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  12. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2005
    ..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  13. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2009
    ..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  14. THROMBIN, SEPSIS AND MECHANISMS OF INFLAMMATION
    Chinnaswamy Tiruppathi; Fiscal Year: 2005
    ..abstract_text> ..
  15. THROMBIN, SEPSIS AND MECHANISMS OF INFLAMMATION
    Chinnaswamy Tiruppathi; Fiscal Year: 2004
    ..abstract_text> ..
  16. THROMBIN, SEPSIS AND MECHANISMS OF INFLAMMATION
    Chinnaswamy Tiruppathi; Fiscal Year: 2003
    ..abstract_text> ..
  17. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2003
    ....
  18. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2002
    ....
  19. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2004
    ....
  20. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2005
    ....
  21. Functional Cooperation of Tissue Factor and Integrins
    Wolfram Ruf; Fiscal Year: 2005
    ..Together, these experiments will characterize a novel pathway of integrin cooperation with TF of relevance for endothelial cell migration. ..
  22. NEW GENETIC MODELS FOR TISSUE FACTOR SIGNALING
    Wolfram Ruf; Fiscal Year: 2004
    ..Identification of such markers will facilitate the quantitation of coagulation signaling in vivo and thus advance clinical efforts to design therapeutic intervention in coagulant cell signaling pathways . ..
  23. SIGNALING OF TISSUE FACTOR IN CELL ADHESION
    Wolfram Ruf; Fiscal Year: 1999
    ..In the long term, elucidation of the molecular details of TF signaling will guide novel therapeutic approaches that intervene with functions of TF in metastasis and angiogenesis. ..
  24. Functional Cooperation of Tissue Factor and Integrins
    Wolfram Ruf; Fiscal Year: 2004
    ..Together, these experiments will characterize a novel pathway of integrin cooperation with TF of relevance for endothelial cell migration. ..
  25. NEW GENETIC MODELS FOR TISSUE FACTOR SIGNALING
    Wolfram Ruf; Fiscal Year: 2005
    ..Identification of such markers will facilitate the quantitation of coagulation signaling in vivo and thus advance clinical efforts to design therapeutic intervention in coagulant cell signaling pathways . ..
  26. TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAY
    Wolfram Ruf; Fiscal Year: 2005
    ..abstract_text> ..
  27. TF Signaling in Systemic Inflammation
    Wolfram Ruf; Fiscal Year: 2010
    ..In depth knowledge of these regulatory pathways of the coagulation cascade will enable therapeutic approaches that do not impair crucial protective mechanisms in various stages of the host response that copes with infectious organisms. ..
  28. Functional Cooperation of Tissue Factor and Integrins
    Wolfram Ruf; Fiscal Year: 2010
    ..Because a prototypic inhibitor of this pathway is effective to attenuate tumor growth in preclinical models, the proposed basic mechanistic studies facilitate a rational translation of this novel concept into the clinic. ..
  29. PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSIS
    Wolfram Ruf; Fiscal Year: 2009
    ..3. ..
  30. TF Signaling in Systemic Inflammation
    Wolfram Ruf; Fiscal Year: 2009
    ..In depth knowledge of these regulatory pathways of the coagulation cascade will enable therapeutic approaches that do not impair crucial protective mechanisms in various stages of the host response that copes with infectious organisms. ..
  31. Functional Cooperation of Tissue Factor and Integrins
    Wolfram Ruf; Fiscal Year: 2009
    ..Because a prototypic inhibitor of this pathway is effective to attenuate tumor growth in preclinical models, the proposed basic mechanistic studies facilitate a rational translation of this novel concept into the clinic. ..
  32. TF Signaling in Systemic Inflammation
    Wolfram Ruf; Fiscal Year: 2008
    ....
  33. TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAY
    Wolfram Ruf; Fiscal Year: 2007
    ..abstract_text> ..
  34. NEW GENETIC MODELS FOR TISSUE FACTOR SIGNALING
    Wolfram Ruf; Fiscal Year: 2007
    ..Identification of such markers will facilitate the quantitation of coagulation signaling in vivo and thus advance clinical efforts to design therapeutic intervention in coagulant cell signaling pathways . ..
  35. Functional Cooperation of Tissue Factor and Integrins
    Wolfram Ruf; Fiscal Year: 2007
    ..Together, these experiments will characterize a novel pathway of integrin cooperation with TF of relevance for endothelial cell migration. ..
  36. TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAY
    Wolfram Ruf; Fiscal Year: 2006
    ..abstract_text> ..
  37. NEW GENETIC MODELS FOR TISSUE FACTOR SIGNALING
    Wolfram Ruf; Fiscal Year: 2006
    ..Identification of such markers will facilitate the quantitation of coagulation signaling in vivo and thus advance clinical efforts to design therapeutic intervention in coagulant cell signaling pathways . ..
  38. Functional Cooperation of Tissue Factor and Integrins
    Wolfram Ruf; Fiscal Year: 2006
    ..Together, these experiments will characterize a novel pathway of integrin cooperation with TF of relevance for endothelial cell migration. ..
  39. PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSIS
    Wolfram Ruf; Fiscal Year: 2010
    ..3. ..
  40. ALLOSTERIC REGULATION OF FACTOR VII FUNCTION
    Wolfram Ruf; Fiscal Year: 2002
    ..The detailed insight into allosteric regulation and determinants of substrate specificity in VIIa may provide novel strategies for therapeutic intervention in inflammatory and thrombotic diseases. ..
  41. SIGNALING OF TISSUE FACTOR IN CELL ADHESION
    Wolfram Ruf; Fiscal Year: 2000
    ..In the long term, elucidation of the molecular details of TF signaling will guide novel therapeutic approaches that intervene with functions of TF in metastasis and angiogenesis. ..
  42. SIGNALING OF TISSUE FACTOR IN CELL ADHESION
    Wolfram Ruf; Fiscal Year: 2001
    ..In the long term, elucidation of the molecular details of TF signaling will guide novel therapeutic approaches that intervene with functions of TF in metastasis and angiogenesis. ..
  43. ALLOSTERIC REGULATION OF FACTOR VII FUNCTION
    Wolfram Ruf; Fiscal Year: 2000
    ..The detailed insight into allosteric regulation and determinants of substrate specificity in VIIa may provide novel strategies for therapeutic intervention in inflammatory and thrombotic diseases. ..
  44. ALLOSTERIC REGULATION OF FACTOR VII FUNCTION
    Wolfram Ruf; Fiscal Year: 2001
    ..The detailed insight into allosteric regulation and determinants of substrate specificity in VIIa may provide novel strategies for therapeutic intervention in inflammatory and thrombotic diseases. ..
  45. Structural Basis of Protease Signaling by Vlla
    Wolfram Ruf; Fiscal Year: 2003
    ..abstract_text> ..
  46. ALLOSTERIC REGULATION OF FACTOR VII FUNCTION
    Wolfram Ruf; Fiscal Year: 1999
    ..The detailed insight into allosteric regulation and determinants of substrate specificity in VIIa may provide novel strategies for therapeutic intervention in inflammatory and thrombotic diseases. ..
  47. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  48. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  49. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2001
    ..These studies will identify and define the important mechanisms involved in bladder inflammation and provide new insights for developing treatment strategies for cystitis. ..
  50. Thrombin,Sepsis and Mechanisms of Inflammation
    Chinnaswamy Tiruppathi; Fiscal Year: 2007
    ..It is hoped that this work will lead to the development of new drug targeting acute lung injury associated with leaky lung microvessel and tissue edema formation. ..
  51. THROMBIN, SEPSIS AND MECHANISMS OF INFLAMMATION
    Chinnaswamy Tiruppathi; Fiscal Year: 2000
    ....
  52. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2004
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  53. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2000
    ..These studies will identify and define the important mechanisms involved in bladder inflammation and provide new insights for developing treatment strategies for cystitis. ..
  54. THROMBIN, SEPSIS AND MECHANISMS OF INFLAMMATION
    Chinnaswamy Tiruppathi; Fiscal Year: 2006
    ..abstract_text> ..
  55. Thrombin,Sepsis and Mechanisms of Inflammation
    Chinnaswamy Tiruppathi; Fiscal Year: 2009
    ..It is hoped that this work will lead to the development of new drug targeting acute lung injury associated with leaky lung microvessel and tissue edema formation. ..
  56. THROMBIN, SEPSIS AND MECHANISMS OF INFLAMMATION
    Chinnaswamy Tiruppathi; Fiscal Year: 2006
    ..abstract_text> ..
  57. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2003
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  58. CTGF-interacting proteins in scleroderma lung fibrosis
    GALINA BOGATKEVICH; Fiscal Year: 2008
    ..The identified protein(s) might serve then as potential target(s) in the treatment of scleroderma pulmonary fibrosis for which no proven, effective therapy currently exists. ..
  59. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2007
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  60. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2006
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  61. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2006
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  62. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2001
    ..These studies will identify and define the important mechanisms involved in bladder inflammation and provide new insights for developing treatment strategies for cystitis. ..
  63. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2003
    ..These studies will identify and define the important mechanisms involved in bladder inflammation and provide new insights for developing treatment strategies for cystitis. ..
  64. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2003
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  65. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2005
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  66. CELL RECEPTORS IN COAGULATION AND ATHEROGENESIS
    SALVATORE PIZZO; Fiscal Year: 1991
    ..These studies were undertaken since cis-DDP is an important antitumor drug which possesses two amine groups. It was felt that cis-DDP might react with alpha 2-M in a manner analogous to MeNH2...
  67. Modulation of Angiogenesis Via the Angiostatin Receptor
    SALVATORE PIZZO; Fiscal Year: 2002
    ..Because of the exposed intravascular localization of the ATP synthesizing enzymes, this project will yield a collection of anti-angiogenic compounds with strong potential for rapid translation into clinical studies. ..
  68. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    ALIREZA REZAIE; Fiscal Year: 2009
    ....
  69. ANTITHROMBIN REGULATION OF COAGULATION PROTEASES
    ALIREZA REZAIE; Fiscal Year: 2003
    ....
  70. CELL RECEPTORS IN COAGULATION AND ATHEROGENESIS
    SALVATORE PIZZO; Fiscal Year: 2004
    ..Future studies will determine whether this pathway also is essential for alpha2M-antigen processing and presentation. ..
  71. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    ALIREZA REZAIE; Fiscal Year: 2004
    ..abstract_text> ..
  72. Diabetes, Inflammation and Vascular Disease
    Susan Smyth; Fiscal Year: 2004
    ..Moreover, our results may have broad implications for the treatment and prevent of accelerated atherosclerosis and thrombosis in diabetes. ..
  73. Lysolipid Signaling in Cardovascular Disease
    Susan Smyth; Fiscal Year: 2006
    ..Our results will provide specific insights into the role of LPA signaling pathways in vascular physiology and pathology and may provide novels targets for the treatment and prevention of atherothrombotic disorders. ..
  74. Radiation injury to the heart
    John Baker; Fiscal Year: 2009
    ..1 ..
  75. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2000
    ....
  76. Modulation of Angiogenesis Via the Angiostatin Receptor
    SALVATORE PIZZO; Fiscal Year: 2001
    ..Because of the exposed intravascular localization of the ATP synthesizing enzymes, this project will yield a collection of anti-angiogenic compounds with strong potential for rapid translation into clinical studies. ..
  77. ANTITHROMBIN REGULATION OF COAGULATION PROTEASES
    ALIREZA REZAIE; Fiscal Year: 2001
    ..abstract_text> ..
  78. ANTITHROMBIN REGULATION OF COAGULATION PROTEASES
    ALIREZA REZAIE; Fiscal Year: 2000
    ..abstract_text> ..
  79. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2001
    ....
  80. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John Baker; Fiscal Year: 2007
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  81. ANTITHROMBIN REGULATION OF COAGULATION PROTEASES
    ALIREZA REZAIE; Fiscal Year: 1999
    ..abstract_text> ..
  82. Modulation of Angiogenesis Via the Angiostatin Receptor
    SALVATORE PIZZO; Fiscal Year: 2005
    ..Because of the exposed intravascular localization of the ATP synthesizing enzymes, this project will yield a collection of anti-angiogenic compounds with strong potential for rapid translation into clinical studies. ..
  83. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John Baker; Fiscal Year: 2002
    ..abstract_text> ..
  84. Microglial Cell Activation by Thrombin in Stroke
    Jonathan Weinstein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  85. Lysolipid Signaling in Cardiovascular Disease
    Susan S Smyth; Fiscal Year: 2010
    ..Completion of the work will provide new insights into pathways that could be targeted to prevent and treat arterial thrombosis. ..
  86. CELL RECEPTORS IN COAGULATION AND ATHEROGENESIS
    SALVATORE PIZZO; Fiscal Year: 2003
    ..Future studies will determine whether this pathway also is essential for alpha2M-antigen processing and presentation. ..
  87. Lysolipid Signaling in Cardovascular Disease
    Susan Smyth; Fiscal Year: 2007
    ..Our results will provide specific insights into the role of LPA signaling pathways in vascular physiology and pathology and may provide novels targets for the treatment and prevention of atherothrombotic disorders. ..