integrin alphavbeta3

Summary

Summary: An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

Top Publications

  1. doi (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1100-8. 2008
  2. ncbi Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 45:1776-83. 2004
  3. ncbi microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    Yun Wu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 46:1707-18. 2005
  4. pmc alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration
    Dominic P White
    Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, UK
    J Cell Biol 177:515-25. 2007
  5. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
  6. pmc Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment
    Jian Ping Xiong
    Program in Leukocyte Biology and Inflammation, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cell Biol 186:589-600. 2009
  7. pmc Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, CB 7295, Lineberger Building, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Med 11:515-21. 2005
  8. pmc Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Angiogenesis 12:177-85. 2009
  9. pmc An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
    Jay S Desgrosellier
    Department of Pathology, Moores University of California San Diego Cancer Center, La Jolla, California, USA
    Nat Med 15:1163-9. 2009
  10. pmc Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction
    Pere Roca-Cusachs
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:16245-50. 2009

Detail Information

Publications251 found, 100 shown here

  1. doi (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1100-8. 2008
    ..The goal of this study was to investigate the feasibility of (68)Ga-labeled RGD peptides for tumor imaging...
  2. ncbi Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 45:1776-83. 2004
    ..In this study, we introduced a polyethylene glycol (PEG; molecular weight, 3,400) moiety between DOTA and RGD and evaluated the 64Cu-DOTA-PEG-RGD tracer for microPET imaging in brain tumor models...
  3. ncbi microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    Yun Wu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 46:1707-18. 2005
    ..Radiolabeled RGD peptides that are integrin specific can be used for noninvasive imaging of integrin expression level as well as for integrin-targeted radionuclide therapy...
  4. pmc alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration
    Dominic P White
    Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, UK
    J Cell Biol 177:515-25. 2007
    ....
  5. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    The integrin alphavbeta3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches...
  6. pmc Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment
    Jian Ping Xiong
    Program in Leukocyte Biology and Inflammation, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cell Biol 186:589-600. 2009
    ....
  7. pmc Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, CB 7295, Lineberger Building, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Med 11:515-21. 2005
    ..Here we show that HCMV also uses integrin alphavbeta3 as a coreceptor...
  8. pmc Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Angiogenesis 12:177-85. 2009
    ..On endothelial cells, an interaction between integrin alphavbeta3 and VEGFR2 seems to be particularly important process during vascularization...
  9. pmc An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
    Jay S Desgrosellier
    Department of Pathology, Moores University of California San Diego Cancer Center, La Jolla, California, USA
    Nat Med 15:1163-9. 2009
    ....
  10. pmc Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction
    Pere Roca-Cusachs
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:16245-50. 2009
    ....
  11. doi (68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin alphavbeta3 PET imaging
    Zhaofei Liu
    Department of Radiology, Biophysics and Bio X, Stanford University, Stanford, CA 94305, USA
    Eur J Nucl Med Mol Imaging 36:947-57. 2009
    ....
  12. ncbi Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis
    Joel J Bergh
    Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208, USA
    Endocrinology 146:2864-71. 2005
    ..These findings suggest that T(4) binds to alpha(V)beta(3) near the RGD recognition site and show that hormone-binding to alpha(V)beta(3) has physiological consequences...
  13. ncbi Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    Weibo Cai
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Anticancer Agents Med Chem 6:407-28. 2006
    ..b>Integrin alphavbeta3 is highly expressed on activated endothelial cells and tumor cells but is not present in resting ..
  14. pmc c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin
    Jingying Xu
    Department of Pediatrics, Neil Bogart Memorial Laboratories, Division of Hematology Oncology, Saban Research Institute at Childrens Hospital Los Angeles, USA
    Blood 115:2709-18. 2010
    ..Thus, endogenous c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5 or by LatB-induced disruption of F-actin...
  15. doi Apolipoprotein(a) stimulates vascular endothelial cell growth and migration and signals through integrin alphaVbeta3
    Lei Liu
    Department of Biochemistry, Queen s University, Kingston, ON K7L3N6, Canada
    Biochem J 418:325-36. 2009
    ..In addition, we showed that LM609, the function-blocking antibody to integrin alphaVbeta3, abrogated the effects of 17K r-apo(a) and Lp(a) on HUVECs...
  16. pmc A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to αvβ3 integrin for therapy
    Klaus Braun
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:326-39. 2010
    ..The ligation was carried out by the Diels Alder Reaction with inverse electron demand (DAR(inv))...
  17. ncbi In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Res 64:8009-14. 2004
    ....
  18. pmc Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers
    C Andrew Boswell
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1088, USA
    Mol Pharm 5:527-39. 2008
    ..30+/-0.03) at 2 h postinjection...
  19. ncbi Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 108:2270-4. 2003
    ..The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to plaque instability, however, cannot be detected directly with any current diagnostic modality...
  20. ncbi Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5838-43. 2003
    ....
  21. ncbi Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
    ..Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients...
  22. pmc Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis
    Alexander S Antonov
    Department of Pathology, BF 231, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Am J Pathol 165:247-58. 2004
    ..b>Integrin alphaVbeta3 plays a role in the differentiation of several cell types, but its involvement in the transition of ..
  23. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
    ....
  24. ncbi Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    F A L M Eskens
    Erasmus Medical Center, Department of Medical Oncology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Cancer 39:917-26. 2003
    ..Cilengitide can be safely administered using a continuous twice-weekly infusion regimen. As DLT was not reached, future trials should explore Cilengitide at different doses...
  25. ncbi Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice
    Zhen Cheng
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, California 94305 5344, USA
    Bioconjug Chem 16:1433-41. 2005
    ..The multmerization of RGD peptide results in moderate improvement of imaging characteristics of the tetramer, compared to that of the monomer and dimeric counterparts...
  26. ncbi Multimodality imaging of tumor integrin alphavbeta3 expression
    Xiaoyuan Chen
    Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University, CA 94305, USA
    Mini Rev Med Chem 6:227-34. 2006
    ..This review highlights some recent advances in multimodality imaging of tumor integrin expression with emphasis on positron emission tomography (PET)...
  27. doi L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    Hung Yun Lin
    Ordway Research Institute, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 296:C980-91. 2009
    ..T(3) action here is inhibited by tetrac alone, but the effect of T(4) is blocked by both tetrac and the RGD peptide...
  28. ncbi Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2
    Xianzhong Zhang
    Molecular Imaging Program at Stanford, MIPS, and Bio X Program, Department of Radiology, Stanford University, California 94305 5484, USA
    J Nucl Med 47:113-21. 2006
    ..We labeled the dimeric RGD peptide E[c(RGDyK)](2) with (18)F and evaluated its tumor-targeting efficacy and pharmacokinetics of (18)F-FB-E[c(RGDyK)](2) ((18)F-FRGD2)...
  29. doi RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis
    Fabienne Danhier
    Universite Catholique de Louvain, Pharmaceutics and Drug Delivery, Louvain Drug Research Institute, avenue E Mounier, 73 B1 73 12, B 1200, Brussels, Belgium
    Mol Pharm 9:2961-73. 2012
    ....
  30. doi Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness
    Alexandre Puissant
    INSERM U1065, Team Cell Death, Differentiation, Inflammation and Cancer, Nice, France
    J Mol Cell Biol 4:207-20. 2012
    ....
  31. ncbi Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:7708-18. 2005
    ..These results suggest that the up-regulated expression of alpha(v)beta3 contributes to the establishment of autocrine TGF-beta loop in scleroderma fibroblasts, and this integrin is a potent target for the treatment of scleroderma...
  32. pmc Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity
    Tomoko Hayashida
    Division of Kidney Diseases, Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 285:30741-51. 2010
    ..Together, our results indicate that decreasing β1 chain causes αvβ3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity...
  33. pmc PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2
    Haokao Gao
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Eur J Nucl Med Mol Imaging 39:683-92. 2012
    ....
  34. doi Dual-targeting of αvβ3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo
    Ewelina Kluza
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Control Release 158:207-14. 2012
    ....
  35. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    ..PAI-1 induces the internalization of urokinase plasminogen activator/receptor and integrin alphavbeta3 from the cell surface...
  36. ncbi Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression
    Zi Bo Li
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA, USA
    Bioconjug Chem 18:1987-94. 2007
    ..This new (18)F labeling method based on click reaction may also be useful for radiolabeling of other biomolecules with azide groups in high yield...
  37. ncbi Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells
    Faith B Davis
    Ordway Research Institute, Inc, Albany, NY 12208, USA
    Cancer Res 66:7270-5. 2006
    ..the thyroid hormone L-thyroxine (T4) stimulates growth of cancer cells via a plasma membrane receptor on integrin alphaVbeta3. The contribution of this recently described receptor for thyroid hormone and receptor-based stimulation of ..
  38. ncbi Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    Amy J Galliher
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Cancer Res 67:3752-8. 2007
    ....
  39. doi Translational implications of nongenomic actions of thyroid hormone initiated at its integrin receptor
    Paul J Davis
    Signal Transduction Laboratory, Ordway Research Institute, Albany, NY 12208, USA
    Am J Physiol Endocrinol Metab 297:E1238-46. 2009
    A thyroid hormone receptor on integrin alphavbeta3 that mediates cell surface-initiated nongenomic actions of thyroid hormone on tumor cell proliferation and on angiogenesis has been described...
  40. ncbi Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 34:267-73. 2007
    ..In this study the alpha(v)beta(3) binding characteristics of an (111)In-labelled monomeric, dimeric and tetrameric RGD analogue were compared...
  41. ncbi Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
    Marcel L Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Res 62:6146-51. 2002
    ..Injection of (90)Y-DOTA-E-[c(RGDfK)](2) induced a significant delay in tumor growth. Potentially, these peptides can be used for peptide receptor radionuclide imaging as well as therapy...
  42. pmc Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers
    Zhaofei Liu
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging 9:21-9. 2010
    b>Integrin alphavbeta3 plays great roles in tumor angiogenesis, invasion, and metastasis...
  43. pmc Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells
    Paul A Dayton
    Department of Biomedical Engineering, UC Davis, CA 95616, USA
    Mol Imaging 3:125-34. 2004
    ....
  44. ncbi microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)
    Zhanhong Wu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    J Nucl Med 48:1536-44. 2007
    ..Here we report an example of (18)F-labeled tetrameric RGD peptide for PET of alpha(v)beta(3) expression in both xenograft and spontaneous tumor models...
  45. pmc Integrin activation dynamics between the RGD-binding site and the headpiece hinge
    Eileen Puklin-Faucher
    Department of Materials, Laboratory of Biologically Oriented Materials, ETH, Zurich CH 8049, Switzerland
    J Biol Chem 284:36557-68. 2009
    ..become strengthened under force), as well as earlier evidence that Ca(2+) at the ADMIDAS results in lower binding affinity, these simulations provide a common structural model for the dynamic process by which integrins become activated...
  46. pmc Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
    Daniel C Worth
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 189:369-83. 2010
    ..These data demonstrate a novel mechanism by which alphavbeta3 integrin acts to locally suppress beta1 integrin activation and regulate protrusion, adhesion dynamics, and persistent migration...
  47. ncbi RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
    Kai Temming
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration GUIDE, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Drug Resist Updat 8:381-402. 2005
    ..Furthermore the in vitro and in vivo efficacy of RGD-targeted therapeutics and diagnostics reported in recent years will be reviewed...
  48. ncbi Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe
    Chun Li
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nucl Med Biol 33:349-58. 2006
    ..In this study, we synthesized and characterized a dual-labeled RGD (Arg-Gly-Asp) peptide and compared nuclear and optical images obtained with this agent...
  49. ncbi Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated
    Hung Yun Lin
    Signal Transduction Laboratory, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Carcinogenesis 29:62-9. 2008
    The stilbene resveratrol (RV) initiates p53-dependent apoptosis via plasma membrane integrin alphaVbeta3 in human cancer cells. A thyroid hormone (L-thyroxine, T(4)) membrane receptor also exists on alphaVbeta3...
  50. pmc Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
    Mihaela Lorger
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 150, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:10666-71. 2009
    ..Targeting this molecular mechanism could prove valuable for the inhibition of brain metastasis...
  51. pmc Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
    ..Our studies demonstrate that alpha(V)beta(3) is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)...
  52. pmc Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature
    Oliver Schnell
    Department of Neurosurgery, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Brain Pathol 18:378-86. 2008
    ....
  53. ncbi Improved tumor targeting of radiolabeled RGD peptides using rapid dose fractionation
    Marcel Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Biother Radiopharm 19:399-404. 2004
    ..In conclusion, dose fractionation resulted in higher radiation doses. However, therapeutic efficacy of the radiolabeled peptide was not significantly improved by dose fractionation...
  54. pmc Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha
    Guoying Jiang
    Department of Biological Sciences, Columbia University, New York, New York 11027, USA
    Biophys J 90:1804-9. 2006
    ..We suggest that RPTPalpha and alphavbeta3 at the leading edge are critical elements for sensing FN matrix rigidity possibly through SFK activation at the edge and downstream signaling...
  55. ncbi Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide
    Xiaoyuan Chen
    University of Southern California, Los Angeles, USA
    Mol Imaging 3:96-104. 2004
    ..5 +/- 0.8. The synergistic effect of polyvalency and improved pharmacokinetics may be responsible for the superior imaging characteristics of [18F]FB-E[c(RGDyK)]2...
  56. doi Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells
    Tzu Hsiu Lai
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    J Cell Physiol 218:334-42. 2009
    ..Taken together, our results indicate that lung derived-SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway...
  57. ncbi Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting
    Marcel Janssen
    Department of Nuclear Medicine and Obstetrics and Gynecology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Biother Radiopharm 17:641-6. 2002
    ..Furthermore, kidney retention of the dimeric peptide was higher than that of the monomeric peptide...
  58. ncbi Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging
    Shuang Liu
    School of Health Sciences, Purdue University, Civil Engineering Building Room 1275, 550 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Mol Pharm 3:472-87. 2006
    b>Integrin alphavbeta3 plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence...
  59. ncbi Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3
    Dilantha B Ellegala
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 108:336-41. 2003
    ..We hypothesized that contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins expressed on the neovascular endothelium could be used to image angiogenesis...
  60. pmc Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers
    Lijun Wang
    School of Health Sciences, Purdue University, Indiana 47907, USA
    Mol Pharm 6:231-45. 2009
    ..Thus, (99m)Tc-3PEG(4)-dimer is a very promising radiotracer for the early detection of integrin alpha(v)beta(3)-positive tumors, and may have the potential for noninvasive monitoring of tumor growth or treatment efficacy...
  61. ncbi MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, MB Eindhoven, The Netherlands
    FASEB J 19:2008-10. 2005
    ....
  62. pmc The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 159:1071-86. 2002
    ..Our findings demonstrate that the pattern of fibronectin receptors expressed on a cell dictates the ability of fibronectin to stimulate RhoA-mediated organization of cell matrix adhesions...
  63. pmc RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe
    Wei Chen
    Translational and Molecular Imaging Institute, Department of Radiology and Medicine, Mt Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 24:1689-99. 2010
    ..This study demonstrates the ability to reroute HDL from its natural targets to tumor blood vessels and its potential for multimodal imaging of tumor-associated processes...
  64. ncbi Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion
    Vadim Pedchenko
    Division of Nephrology, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:2772-80. 2004
    ..Therefore, the RGD site, in addition to non-RGD motifs, may contribute to the mechanisms of endothelial cell adhesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain...
  65. ncbi Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
    Helen Hutchings
    GDR CNRS 1927 Angiogenese and UMR CNRS 5089, Institut de Pharmacologie et Biologie Structurale, Toulouse, France
    FASEB J 17:1520-2. 2003
    ..We have thus determined a new VEGF receptor-independent role for immobilized VEGF in supporting cell adhesion and survival through interactions with integrins...
  66. doi Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway
    Yi Chin Fong
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Lung Cancer 64:263-70. 2009
    ..Taken together, these results suggest that OPN acts through alphavbeta3 integrin, which in turn activates the FAK, PI3K, Akt, ERK and NF-kappaB pathways, contributing to the migration of lung cancer cells...
  67. pmc Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication
    Tamara Hermosilla
    Program of Cell and Molecular Biology, FONDAP, Center for Molecular Studies of the Cell CEMC, Institute of Biomedical Sciences ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1783:1111-20. 2008
    ..This interaction was promoted by divalent cations and was species-independent. Together, these results demonstrate that the alphavbeta3 integrin heterodimer interacts directly with Thy-1 present on neuronal cells to stimulate astrocytes...
  68. pmc Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone
    Erica K Sloan
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Breast Cancer Res 8:R20. 2006
    ....
  69. ncbi Integrin alpha(v)beta(3), metalloproteinases, and sphingomyelinase-2 mediate urokinase mitogenic effect
    Françoise Maupas-Schwalm
    Inserm U858 Team 10, Dept of Biochemistry and Molecular Biology, Faculty of Medicine Rangueil, University Paul Sabatier Toulouse 3, IFR 150, Toulouse, France
    Cell Signal 21:1925-34. 2009
    ..These findings highlight a new signaling mechanism for uPA, and suggest that, upon uPA stimulation, uPAR, MMPs, integrin alpha(v)beta(3) and NSMase-2 form a signaling complex that take part in mitogenic signaling in ECV304 cells...
  70. pmc Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors
    Yunpeng Ye
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Med Chem 49:2268-75. 2006
    ..Optimization of the spatial alignment of the RGD moieties through careful molecular design and library construction could induce multivalent ligand-receptor interactions useful for in vivo tumor imaging and tumor-targeted therapy...
  71. doi JWA regulates melanoma metastasis by integrin alphaVbeta3 signaling
    J Bai
    Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, People s Republic of China
    Oncogene 29:1227-37. 2010
    ..These findings suggest that JWA suppresses melanoma metastasis and may serve a potential therapeutic target for human melanoma...
  72. ncbi Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture
    Charles S Wallace
    Department of Biomedical Engineering, Duke University, Durham, NC 27708 0281, USA
    Am J Physiol Heart Circ Physiol 293:H1978-86. 2007
    ..These changes in the type of adhesions may alter EC signaling pathways in tissue-engineered blood vessels...
  73. ncbi Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium
    Anja Saalbach
    Saxon Academy of Science, D 04107 Leipzig, Germany
    Oncogene 24:4710-20. 2005
    ..These data explain at least in part the high tumorigenicity of alphavbeta3-expressing melanoma cells and the association of alphavbeta3-positive melanoma cells with a high risk of metastasis and poor prognosis...
  74. ncbi Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models
    Jeffrey M Albert
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Radiat Oncol Biol Phys 65:1536-43. 2006
    ..Radiotherapy also inhibits tumor growth and affects vasculature. We explored the combination of integrin antagonist Cilengitide (EMD 121974) and ionizing radiation...
  75. ncbi Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer
    Shuang Liu
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907 2051, USA
    Bioconjug Chem 18:438-46. 2007
    b>Integrin alphavbeta3 plays a critical role in tumor angiogenesis and metastasis...
  76. pmc Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour
    Mark R Morgan
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester, UK
    IUBMB Life 61:731-8. 2009
    ..By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated...
  77. doi 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expression
    Clemens Decristoforo
    Department of Nuclear Medicine, Medizinische Universitat Innsbruck, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 35:1507-15. 2008
    ..Recently, we demonstrated using [(18)F]Galacto-RGD that monitoring of alphavbeta3 expression is feasible. Here, we introduce (68)Ga- and (111)In-labelled derivatives and compare them with [(18)F]Galacto-RGD...
  78. pmc Integrin αvβ3-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy
    Huan Xie
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77030, USA
    Int J Nanomedicine 6:259-69. 2011
    ..Active targeting of NSs to integrin αvβ3 offers the potential to increase accumulation preferentially in tumors and thereby enhance therapy efficacy...
  79. pmc Getting a grip on Thy-1 signaling
    Thomas H Barker
    Biomedical Engineering, GA Tech Emory, 313 Ferst Drive, Ste 3111 Atlanta, GA 30332 0535, USA
    Biochim Biophys Acta 1793:921-3. 2009
    ..As knowledge of Thy-1 approaches its fiftieth year, it is critical to begin to synthesize insights from different fields to determine how this heretofore enigmatic molecule modulates cell behavior in both cis and trans...
  80. doi Imaging of integrin alphavbeta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Metastasis Rev 27:631-44. 2008
    The integrin alphavbeta3 plays an important role in angiogenesis and tumor metastasis. It is expressed on activated endothelial cells as well as some tumor cells...
  81. pmc Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pa
    Ping Xie
    Department of Pathology and Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:34131-46. 2011
    ..These in vivo and in vitro studies demonstrate an essential role of TINag in cellular survival to maintain proper tubular homeostasis utilizing integrin αvβ3 and downstream effectors...
  82. pmc Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases
    R L Wilder
    Clinical Development, MedImmune, Inc, 35 W Watkins Mill Road, Gaithersburg, MD 20878, USA
    Ann Rheum Dis 61:ii96-9. 2002
    ..It blocks the interaction of alpha V beta 3 with various ligands such as osteopontin and vitronectin. Clinical trials with Vitaxin in patients with RA are in progress...
  83. doi Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB
    Sylvie Monferran
    Institut Claudius Regaud, INSERMU563, Department of Oncogenesis, Signalling and Therapeutic Innovation, France
    Int J Cancer 123:357-64. 2008
    ....
  84. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..Our data suggest that beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2...
  85. pmc RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages
    Gotz von Wichert
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Cell Biol 161:143-53. 2003
    ....
  86. doi Integrin alphavbeta3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line
    Dong Seok Kim
    National Research Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 134 Sinchon Dong Seodaemun Gu, 120 749 Seoul, Republic of Korea
    Biochem Biophys Res Commun 377:479-83. 2008
    ..Further analyses clearly indicated that interaction of the disintegrin and integrin alphavbeta3 results in the TIMP-1 promoter activation via c-fos to suppress TNF-alpha-induced cancer cell invasion...
  87. doi Structural basis for the interaction of isoDGR with the RGD-binding site of alphavbeta3 integrin
    Andrea Spitaleri
    Dulbecco Telethon Institute Biomolecular NMR Laboratory c o S Raffaele Scientific Institute, 20132 Milan, Italy
    J Biol Chem 283:19757-68. 2008
    ....
  88. ncbi New multifunctional molecular conjugate vector for targeting, imaging, and therapy of tumors
    Elisabeth Garanger
    Groupe de Recherche sur le Cancer du Poumon, INSERM U578, Institut Albert Bonniot, La Tronche 38706 Cedex, France
    Mol Ther 12:1168-75. 2005
    ....
  89. ncbi Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells
    Peter C Baciu
    Allergan Inc, 2525 Dupont Dr, Irvine, CA 92612, USA
    Exp Cell Res 291:167-75. 2003
    ..In MT1-MMP-deficient cells, integrin alphavbeta3 suppressed the functional activity of the collagen-binding alpha2beta1 integrin receptor and diminished ..
  90. ncbi Differential transmission of actin motion within focal adhesions
    Ke Hu
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 315:111-5. 2007
    ....
  91. doi Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit's experimental model
    Cynthia G El Kahi
    Department of Human Morphology, American University of Beirut Medical Center, Beirut, Lebanon
    Int Wound J 6:214-24. 2009
    ..The purpose of this work is to study the modulation of myofibroblasts and integrin alphavbeta3 in a full thickness wound performed on rabbits treated with different topical agents using: (1) saline, (2) ..
  92. ncbi Integrin receptor imaging of breast cancer: a proof-of-concept study to evaluate 99mTc-NC100692
    Tore Bach-Gansmo
    Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Nucl Med 47:1434-9. 2006
    ..The agent is a small peptide with high affinity for integrin receptors that are upregulated and expressed preferentially on proliferating endothelial cells...
  93. doi Multimeric system of 99mTc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor α(v)β(3) expression
    Enrique Morales-Avila
    Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Estado de México, Mexico
    Bioconjug Chem 22:913-22. 2011
    ..18 ± 0.57% ID/g. Micro-SPECT/CT images showed evident tumor uptake. (99m)Tc-AuNP-RGD demonstrates properties suitable for use as a target-specific agent for molecular imaging of tumor α(V)β(3) expression...
  94. pmc Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA
    Ana Maria Avalos
    Laboratory of Cellular Communication, University of Chile, Santiago 8380453, Chile
    J Cell Sci 122:3462-71. 2009
    ..These observations are likely to be of widespread biological relevance because Thy-1-integrin binding is reportedly relevant to melanoma invasion, monocyte transmigration through endothelial cells and host defense mechanisms...
  95. pmc Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression
    Longxuan Li
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cereb Blood Flow Metab 30:1031-43. 2010
    ....
  96. doi Evaluation of copper-64 labeled AmBaSar conjugated cyclic RGD peptide for improved microPET imaging of integrin alphavbeta3 expression
    Hancheng Cai
    Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Bioconjug Chem 21:1417-24. 2010
    ..The AmBaSar chelator will also have general applications for (64)Cu labeling of various bioactive molecules in high radiochemical yield and high in vivo stability...
  97. pmc The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere)
    Haiyan Lu
    Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Mol Pharmacol 69:1207-15. 2006
    ..These complementary actions could account for their synergistic effects on HUVEC...
  98. ncbi Synthesis and biological evaluation of potent alphavbeta3-integrin receptor antagonists
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nucl Med Biol 33:953-61. 2006
    ..Due to the selective expression of alpha(v)beta(3) integrin in tumors, radiolabeled RGD peptides and peptidomimetics are attractive candidates for tumor targeting...
  99. ncbi Identification and functions of the plasma membrane receptor for thyroid hormone analogues
    Hung Yun Lin
    Signal Transduction Laboratory, Ordway Research Institute, Albany, New York 12208, USA
    Discov Med 11:337-47. 2011
    ..Thus, the receptor described on integrin αvβ3 for T(4) and T(3), the function of which is materially affected by tetrac and nanotetrac, provides insight into tumor cell biology and vascular biology...
  100. pmc MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:1224-33. 2011
    ..4 h), using the chelator desferrioxamine-p-SCN (Df) for imaging tumor integrin α(v)β(3)...
  101. pmc Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress
    David R Clemmons
    Department of Medicine, Division of Endocrinology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA
    Growth Horm IGF Res 17:265-70. 2007
    ..SMC secrete increased concentrations of thrombospondin, vitronectin and osteopontin, ligands for the integrin alphaVbeta3. Activation of alphaVbeta3 stimulates recruitment of a tyrosine phosphatase, SHP-2...

Research Grants75

  1. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2007
    ..Important questions stemming from this are: 1) Is RGDfV-induced ceramide required for integrin alphavbeta3/beta3-mediated apoptosis; 2) Do integrins alphavbeta3/beta5 control p53 activity via their regulatory ..
  2. Activation of alpha5beta3 integrin on blood and endothelial cells
    Tatiana Byzova; Fiscal Year: 2007
    ..The central hypothesis of this proposal is that cellular interaction of integrin alphavbeta3 with matrix ligands is tightly controlled and depends on the activation state of the receptor...
  3. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ....
  4. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1991
    ....
  5. Tissue Factor, Flow, and Platelet Adhesion/Aggregation on Activated Endothelium
    Eric Grabowski; Fiscal Year: 2009
    ..Our studies promise to clarify the potential of treatments for HUS directed at blocking the above adhesive molecules and vessel wall tissue factor. ..
  6. Tissue Factor, Flow, and Platelet Adhesion/Aggregation on Activated Endothelium
    ERIC FRANKLIN GRABOWSKI; Fiscal Year: 2010
    ..Our studies promise to clarify the potential of treatments for HUS directed at blocking the above adhesive molecules and vessel wall tissue factor. ..
  7. TUMOR CELL ADHESIVE GLYCOPROTEINS AND METASTASIS
    KENNETH HONN; Fiscal Year: 1993
    ..e., alpha-II-b-beta-3 and alpha- v-beta-3 ) to cellular functions correlated with high metastatic potential...
  8. TUMOR CELL ADHESIVE GLYCOPROTEINS AND METASTASIS
    KENNETH HONN; Fiscal Year: 1992
    ..e., alpha-II-b-beta-3 and alpha- v-beta-3 ) to cellular functions correlated with high metastatic potential...
  9. CONTROL OF PERICELLULAR PLASMIN BY MATRIX VITRONECTIN
    PAULA MC KEOWN LONGO; Fiscal Year: 1993
    ..These studies will contribute towards the understanding of processes such as angiogenesis and tumor invasion...
  10. ENDOMETRIAL INTEGRINS--A ROLE IN UTERINE RECEPTIVITY
    Bruce Lessey; Fiscal Year: 1992
    ....
  11. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2004
    ..Third, the crystal structure of the extracellular domain of integrin alphavBeta3 has just been published, providing a major breakthrough and an opportunity to design incisive approaches to ..
  12. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2003
    ..Third, the crystal structure of the extracellular domain of integrin alphavBeta3 has just been published, providing a major breakthrough and an opportunity to design incisive approaches to ..
  13. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2002
    ..Third, the crystal structure of the extracellular domain of integrin alphavBeta3 has just been published, providing a major breakthrough and an opportunity to design incisive approaches to ..
  14. MEMBRANE PROTEINS IN BLOOD COAGULATION
    Bruce Furie; Fiscal Year: 1990
    ..Core support facilities include and Administration Core (Core A), and Analytical and Preparative Core (Core B), and a Tissue Culture core (Core C)...
  15. MATRIX PROTEIN/INTEGRIN MEDIATED OSTEOCLAST REGULATION
    Keith Hruska; Fiscal Year: 1999
    ..It is suggested that the results of the proposed studies will represent significant advances in the cell biology of the osteoclast and provide important leads for pharmacologic product development. ..
  16. IN VIVO/IN VITRO STUDIES OF BONE ACIDIC GLYCOPROTEIN-75
    JEFFREY GORSKI; Fiscal Year: 1991
    ....
  17. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 1999
    ..These studies should provide important information about the mechanisms by which asbestos induces apoptosis in mesothelial cells and the role of asbestos-induced apoptosis in asbestos-induced pathology. ..
  18. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 2000
    ..These studies should provide important information about the mechanisms by which asbestos induces apoptosis in mesothelial cells and the role of asbestos-induced apoptosis in asbestos-induced pathology. ..
  19. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 2000
    ..These studies should provide important information about the mechanisms by which asbestos induces apoptosis in mesothelial cells and the role of asbestos-induced apoptosis in asbestos-induced pathology. ..
  20. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 2001
    ..These studies should provide important information about the mechanisms by which asbestos induces apoptosis in mesothelial cells and the role of asbestos-induced apoptosis in asbestos-induced pathology. ..
  21. PATHOGENESIS OF OPPORTUNISTIC INFECTION DUE TO MAC
    Antonino Catanzaro; Fiscal Year: 1992
    ....
  22. ENDOMETRIAL INTEGRINS AND UTERINE RECEPTIVITY
    Bruce Lessey; Fiscal Year: 1999
    ..It is expected that a better understanding of the mediators of normal cycle fecundity will improve our ability to diagnosis and treat couples with infertility as well as to aid in developing new methods of contraception. ..
  23. ENDOMETRIAL INTEGRINS AND UTERINE RECEPTIVITY
    Bruce Lessey; Fiscal Year: 2000
    ..It is expected that a better understanding of the mediators of normal cycle fecundity will improve our ability to diagnosis and treat couples with infertility as well as to aid in developing new methods of contraception. ..
  24. ENDOMETRIAL INTEGRINS AND UTERINE RECEPTIVITY
    Bruce Lessey; Fiscal Year: 2001
    ..It is expected that a better understanding of the mediators of normal cycle fecundity will improve our ability to diagnosis and treat couples with infertility as well as to aid in developing new methods of contraception. ..
  25. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2004
    ..Important questions stemming from this are: 1) Is RGDfV-induced ceramide required for integrin alphavbeta3/beta3-mediated apoptosis; 2) Do integrins alphavbeta3/beta5 control p53 activity via their regulatory ..
  26. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2006
    ..Important questions stemming from this are: 1) Is RGDfV-induced ceramide required for integrin alphavbeta3/beta3-mediated apoptosis; 2) Do integrins alphavbeta3/beta5 control p53 activity via their regulatory ..
  27. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2005
    ..Important questions stemming from this are: 1) Is RGDfV-induced ceramide required for integrin alphavbeta3/beta3-mediated apoptosis; 2) Do integrins alphavbeta3/beta5 control p53 activity via their regulatory ..
  28. INTEGRINS AND PMN MOTILITY
    WILLIAM HENDEY; Fiscal Year: 2000
    ..Finally, relationship between beta2 phosphorylation and beta3-mediated attachment or detachment will be assessed. ..
  29. INTEGRINS AND PMN MOTILITY
    WILLIAM HENDEY; Fiscal Year: 1999
    ..Finally, relationship between beta2 phosphorylation and beta3-mediated attachment or detachment will be assessed. ..
  30. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2002
    ..The most significant advances during the previous support period include: 1) the identification of the integrin alphaVbeta3 signaling pathway as the most likely to be affected by the absence of Src in the osteoclast, and 2) the ..
  31. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2000
    ..The most significant advances during the previous support period include: 1) the identification of the integrin alphaVbeta3 signaling pathway as the most likely to be affected by the absence of Src in the osteoclast, and 2) the ..
  32. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2004
    ..The most significant advances during the previous support period include: 1) the identification of the integrin alphaVbeta3 signaling pathway as the most likely to be affected by the absence of Src in the osteoclast, and 2) the ..
  33. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2001
    ..The most significant advances during the previous support period include: 1) the identification of the integrin alphaVbeta3 signaling pathway as the most likely to be affected by the absence of Src in the osteoclast, and 2) the ..
  34. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2003
    ..The most significant advances during the previous support period include: 1) the identification of the integrin alphaVbeta3 signaling pathway as the most likely to be affected by the absence of Src in the osteoclast, and 2) the ..
  35. Cbl-b in osteoclast function
    Archana Sanjay; Fiscal Year: 2003
    ..c-Cbl protein promotes the down-regulation of various receptors, and the increased levels of RANK suggest that Cbl-b may play a similar role in regulating RANK activity in OC)...
  36. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2000
    ..This JAM-1 induced endothelial cell migration is specific to integrin alphaVbeta3, the vitronectin receptor...
  37. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
    ..This JAM-1 induced endothelial cell migration is specific to integrin alphaVbeta3, the vitronectin receptor...
  38. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2002
    ..This JAM-1 induced endothelial cell migration is specific to integrin alphaVbeta3, the vitronectin receptor...
  39. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2001
    ..This JAM-1 induced endothelial cell migration is specific to integrin alphaVbeta3, the vitronectin receptor...
  40. Vascular endothelial cell integrins in angiogenesis
    DONALD DURDEN; Fiscal Year: 2000
    ..This integrated approach will likely yield novel therapeutic agents for the treatment of neuroblastoma and other tumors...
  41. SHEAR STRESS EFFECTS ON ENDOTHELIAL CELL FOCAL CONTACTS
    PEGGY GIRARD; Fiscal Year: 1992
    ..Shear stress-induced alterations in the levels and activity of urokinase-type plaminogen activator and metalloproteinases including collagenases will be examined using immunological methods and SDS-substrate gel zymography...
  42. REGULATION OF CELL MIGRATION IN VASCULAR REMODELING
    Eric Howard; Fiscal Year: 1999
    ..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
  43. REGULATION OF CELL MIGRATION IN VASCULAR REMODELING
    Eric Howard; Fiscal Year: 2002
    ..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
  44. REGULATION OF CELL MIGRATION IN VASCULAR REMODELING
    Eric Howard; Fiscal Year: 2001
    ..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
  45. REGULATION OF CELL MIGRATION IN VASCULAR REMODELING
    Eric Howard; Fiscal Year: 2000
    ..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
  46. Activation of blood and endothelial cell a5b3 integrin
    Tatiana Byzova; Fiscal Year: 2005
    ..The central hypothesis of this proposal is that cellular interaction of integrin alphavbeta3 with matrix ligands is tightly controlled and depends on the activation state of the receptor...
  47. Activation of integrin on blood & endothelial cells
    Tatiana Byzova; Fiscal Year: 2003
    ..The central hypothesis of this proposal is that cellular interaction of integrin alphavbeta3 with matrix ligands is tightly controlled and depends on the activation state of the receptor...
  48. ENDOMETRIOSIS, INTEGRINS AND INFERTILITY
    Bruce Lessey; Fiscal Year: 1992
    ....
  49. MECHANISMS OF AVB3 INTEGRIN MEDIATED BONE RESORPTION
    Steven Teitelbaum; Fiscal Year: 2002
    ..In fact, by mechanisms poorly understood, the integrin alphavbeta3, which recognizes bone matrix-residing proteins, is essential to osteoclastic bone resorption, in vitro and ..
  50. MECHANISMS OF AVB3 INTEGRIN MEDIATED BONE RESORPTION
    Steven Teitelbaum; Fiscal Year: 2003
    ..In fact, by mechanisms poorly understood, the integrin alphavbeta3, which recognizes bone matrix-residing proteins, is essential to osteoclastic bone resorption, in vitro and ..
  51. THROMBUS FORMATION AND DISSOLUTION
    David Loskutoff; Fiscal Year: 2001
    ..The distinct roles of fibrinogen, fibronectin, vitronectin and integrin alphavbeta3 in platelet thrombus formation at normal and pathological shear rates will be assessed. Dr...
  52. THROMBUS FORMATION AND DISSOLUTION
    David Loskutoff; Fiscal Year: 2000
    ..The distinct roles of fibrinogen, fibronectin, vitronectin and integrin alphavbeta3 in platelet thrombus formation at normal and pathological shear rates will be assessed. Dr...
  53. L1 CAM AND MELANOMA PROGRESSION AND ANGIOGENESIS
    Anthony Montgomery; Fiscal Year: 2000
    ..tested, it will be determined whether L1 is angiogenic by virtue of its ability to interact with the integrin alphavbeta3 expressed on host vasculature...
  54. THROMBUS FORMATION AND DISSOLUTION
    David Loskutoff; Fiscal Year: 2002
    ..The distinct roles of fibrinogen, fibronectin, vitronectin and integrin alphavbeta3 in platelet thrombus formation at normal and pathological shear rates will be assessed. Dr...
  55. THROMBUS FORMATION AND DISSOLUTION
    David Loskutoff; Fiscal Year: 2003
    ..The distinct roles of fibrinogen, fibronectin, vitronectin and integrin alphavbeta3 in platelet thrombus formation at normal and pathological shear rates will be assessed. Dr...
  56. L1 CAM AND MELANOMA PROGRESSION AND ANGIOGENESIS
    Anthony Montgomery; Fiscal Year: 2002
    ..tested, it will be determined whether L1 is angiogenic by virtue of its ability to interact with the integrin alphavbeta3 expressed on host vasculature...
  57. L1 CAM AND MELANOMA PROGRESSION AND ANGIOGENESIS
    Anthony Montgomery; Fiscal Year: 1999
    ..tested, it will be determined whether L1 is angiogenic by virtue of its ability to interact with the integrin alphavbeta3 expressed on host vasculature...
  58. THROMBUS FORMATION AND DISSOLUTION
    David Loskutoff; Fiscal Year: 2004
    ..The distinct roles of fibrinogen, fibronectin, vitronectin and integrin alphavbeta3 in platelet thrombus formation at normal and pathological shear rates will be assessed. Dr...
  59. INTEGRIN, AVB3, IN OSTEOCLAST PRECURSOR
    Keith Hruska; Fiscal Year: 1992
    ..Successful completion of these studies should provide us major insights into the control of osteoclast function necessary to manipulate bone resorption in diseases such as osteoporosis and renal osteodystrophy...
  60. SIGNAL TRANSDUCTION IN ATHEROSCLEROSIS
    Garret FitzGerald; Fiscal Year: 2007
    ..Factors which underlie the cell to cell heterogeneity of this interaction are likely to contribute to the focal nature of atherogenesis. ..
  61. SIGNAL TRANSDUCTION IN ATHEROSCLEROSIS
    Garret FitzGerald; Fiscal Year: 2005
    ..Factors which underlie the cell to cell heterogeneity of this interaction are likely to contribute to the focal nature of atherogenesis. ..
  62. SIGNAL TRANSDUCTION IN ATHEROSCLEROSIS
    Garret FitzGerald; Fiscal Year: 2006
    ..Factors which underlie the cell to cell heterogeneity of this interaction are likely to contribute to the focal nature of atherogenesis. ..
  63. SIGNAL TRANSDUCTION IN ATHEROSCLEROSIS
    Garret FitzGerald; Fiscal Year: 2004
    ..Factors which underlie the cell to cell heterogeneity of this interaction are likely to contribute to the focal nature of atherogenesis. ..
  64. Activation of blood and endothelial cell a5b3 integrin
    Tatiana Byzova; Fiscal Year: 2006
    ..The central hypothesis of this proposal is that cellular interaction of integrin alphavbeta3 with matrix ligands is tightly controlled and depends on the activation state of the receptor...
  65. Activation of blood and endothelial cell a5b3 integrin
    Tatiana Byzova; Fiscal Year: 2004
    ..The central hypothesis of this proposal is that cellular interaction of integrin alphavbeta3 with matrix ligands is tightly controlled and depends on the activation state of the receptor...