integrin alphavbeta3

Summary

Summary: An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

Top Publications

  1. pmc Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction
    Pere Roca-Cusachs
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:16245-50. 2009
  2. ncbi (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1100-8. 2008
  3. ncbi Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 45:1776-83. 2004
  4. ncbi microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    Yun Wu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 46:1707-18. 2005
  5. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
  6. pmc alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration
    Dominic P White
    Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, UK
    J Cell Biol 177:515-25. 2007
  7. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
  8. pmc Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, CB 7295, Lineberger Building, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Med 11:515-21. 2005
  9. pmc Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Angiogenesis 12:177-85. 2009
  10. ncbi Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008

Detail Information

Publications282 found, 100 shown here

  1. pmc Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction
    Pere Roca-Cusachs
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:16245-50. 2009
    ....
  2. ncbi (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1100-8. 2008
    ..The goal of this study was to investigate the feasibility of (68)Ga-labeled RGD peptides for tumor imaging...
  3. ncbi Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 45:1776-83. 2004
    ..In this study, we introduced a polyethylene glycol (PEG; molecular weight, 3,400) moiety between DOTA and RGD and evaluated the 64Cu-DOTA-PEG-RGD tracer for microPET imaging in brain tumor models...
  4. ncbi microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    Yun Wu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 46:1707-18. 2005
    ..Radiolabeled RGD peptides that are integrin specific can be used for noninvasive imaging of integrin expression level as well as for integrin-targeted radionuclide therapy...
  5. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
    ..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth...
  6. pmc alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration
    Dominic P White
    Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, UK
    J Cell Biol 177:515-25. 2007
    ....
  7. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    The integrin alphavbeta3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches...
  8. pmc Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, CB 7295, Lineberger Building, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Med 11:515-21. 2005
    ..Here we show that HCMV also uses integrin alphavbeta3 as a coreceptor...
  9. pmc Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Angiogenesis 12:177-85. 2009
    ..On endothelial cells, an interaction between integrin alphavbeta3 and VEGFR2 seems to be particularly important process during vascularization...
  10. ncbi Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  11. pmc An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
    Jay S Desgrosellier
    Department of Pathology, Moores University of California San Diego Cancer Center, La Jolla, California, USA
    Nat Med 15:1163-9. 2009
    ....
  12. ncbi (68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin alphavbeta3 PET imaging
    Zhaofei Liu
    Department of Radiology, Biophysics and Bio X, Stanford University, Stanford, CA 94305, USA
    Eur J Nucl Med Mol Imaging 36:947-57. 2009
    ....
  13. ncbi Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis
    Joel J Bergh
    Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208, USA
    Endocrinology 146:2864-71. 2005
    ..These findings suggest that T(4) binds to alpha(V)beta(3) near the RGD recognition site and show that hormone-binding to alpha(V)beta(3) has physiological consequences...
  14. ncbi Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    Weibo Cai
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Anticancer Agents Med Chem 6:407-28. 2006
    ..b>Integrin alphavbeta3 is highly expressed on activated endothelial cells and tumor cells but is not present in resting ..
  15. ncbi Dual-targeting of αvβ3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo
    Ewelina Kluza
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Control Release 158:207-14. 2012
    ....
  16. ncbi Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit's experimental model
    Cynthia G El Kahi
    Department of Human Morphology, American University of Beirut Medical Center, Beirut, Lebanon
    Int Wound J 6:214-24. 2009
    ..The purpose of this work is to study the modulation of myofibroblasts and integrin alphavbeta3 in a full thickness wound performed on rabbits treated with different topical agents using: (1) saline, (2) ..
  17. pmc A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to αvβ3 integrin for therapy
    Klaus Braun
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:326-39. 2010
    ..The ligation was carried out by the Diels Alder Reaction with inverse electron demand (DAR(inv))...
  18. ncbi Apolipoprotein(a) stimulates vascular endothelial cell growth and migration and signals through integrin alphaVbeta3
    Lei Liu
    Department of Biochemistry, Queen s University, Kingston, ON K7L3N6, Canada
    Biochem J 418:325-36. 2009
    ..In addition, we showed that LM609, the function-blocking antibody to integrin alphaVbeta3, abrogated the effects of 17K r-apo(a) and Lp(a) on HUVECs...
  19. ncbi In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Res 64:8009-14. 2004
    ....
  20. pmc Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers
    C Andrew Boswell
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1088, USA
    Mol Pharm 5:527-39. 2008
    ..30+/-0.03) at 2 h postinjection...
  21. ncbi Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
    ..We have developed [18F]Galacto-RGD, a highly alpha(v)beta3-selective tracer for positron emission tomography (PET). Here, we show, in man, that the intensity of [18F]Galacto-RGD uptake correlates with alpha(v)beta3 expression...
  22. ncbi Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
    ..Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients...
  23. pmc MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells
    Chandramu Chetty
    Program of Cancer Biology, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
    Int J Cancer 127:1081-95. 2010
    ..In summary, these data provide new insights into the mechanisms underlying MMP-2-mediated VEGF expression in lung tumor angiogenesis...
  24. ncbi Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled αVbeta3-integrin and αV beta5-integrin imaging agent
    Mark R Battle
    GE Healthcare MDx Research, The Grove Centre, Amersham, UK
    J Nucl Med 52:424-30. 2011
    ..In this study, (18)F-fluciclatide was used to examine the response of human glioblastoma xenografts to treatment with the antiangiogenic agent sunitinib...
  25. pmc The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 159:1071-86. 2002
    ..Our findings demonstrate that the pattern of fibronectin receptors expressed on a cell dictates the ability of fibronectin to stimulate RhoA-mediated organization of cell matrix adhesions...
  26. pmc Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment
    Jian Ping Xiong
    Program in Leukocyte Biology and Inflammation, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cell Biol 186:589-600. 2009
    ....
  27. ncbi RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
    Kai Temming
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration GUIDE, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Drug Resist Updat 8:381-402. 2005
    ..Furthermore the in vitro and in vivo efficacy of RGD-targeted therapeutics and diagnostics reported in recent years will be reviewed...
  28. pmc Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
    Mihaela Lorger
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 150, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:10666-71. 2009
    ..Targeting this molecular mechanism could prove valuable for the inhibition of brain metastasis...
  29. pmc Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis
    Alexander S Antonov
    Department of Pathology, BF 231, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Am J Pathol 165:247-58. 2004
    ..b>Integrin alphaVbeta3 plays a role in the differentiation of several cell types, but its involvement in the transition of ..
  30. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
    ....
  31. ncbi Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    F A L M Eskens
    Erasmus Medical Center, Department of Medical Oncology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Cancer 39:917-26. 2003
    ..Cilengitide can be safely administered using a continuous twice-weekly infusion regimen. As DLT was not reached, future trials should explore Cilengitide at different doses...
  32. pmc Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice
    Zhen Cheng
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, California 94305 5344, USA
    Bioconjug Chem 16:1433-41. 2005
    ..The multmerization of RGD peptide results in moderate improvement of imaging characteristics of the tetramer, compared to that of the monomer and dimeric counterparts...
  33. ncbi L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    Hung Yun Lin
    Ordway Research Institute, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 296:C980-91. 2009
    ..T(3) action here is inhibited by tetrac alone, but the effect of T(4) is blocked by both tetrac and the RGD peptide...
  34. pmc Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2
    Xianzhong Zhang
    Molecular Imaging Program at Stanford, MIPS, and Bio X Program, Department of Radiology, Stanford University, California 94305 5484, USA
    J Nucl Med 47:113-21. 2006
    ..We labeled the dimeric RGD peptide E[c(RGDyK)](2) with (18)F and evaluated its tumor-targeting efficacy and pharmacokinetics of (18)F-FB-E[c(RGDyK)](2) ((18)F-FRGD2)...
  35. ncbi Multimodality imaging of tumor integrin alphavbeta3 expression
    Xiaoyuan Chen
    Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University, CA 94305, USA
    Mini Rev Med Chem 6:227-34. 2006
    ..This review highlights some recent advances in multimodality imaging of tumor integrin expression with emphasis on positron emission tomography (PET)...
  36. pmc Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
    Eleonora Patsenker
    Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
    Hepatology 50:1501-11. 2009
    The vitronectin receptor integrin alphavbeta3 promotes angiogenesis by mediating migration and proliferation of endothelial cells, but also drives fibrogenic activation of hepatic stellate cells (HSCs) in vitro...
  37. ncbi Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity
    John F McDonald
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:17301-11. 2004
    ....
  38. ncbi The relationship between bone metastasis from human breast cancer and integrin alpha(v)beta3 expression
    Shin Takayama
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Anticancer Res 25:79-83. 2005
    ..Integrin alpha(v)beta3 mediates the attachment of osteoclasts to bone matrix, and it is overexpressed in bone-residing breast cancer cells. We studied BM from breast cancer in relation to its Integrin alpha(v)beta3 expression...
  39. ncbi Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 102:2108-14. 2003
    ..Among the integrins involved in this process, integrin alphavbeta3 is specific to basic fibroblast growth factor (bFGF)-induced angiogenesis...
  40. ncbi Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture
    Charles S Wallace
    Department of Biomedical Engineering, Duke University, Durham, NC 27708 0281, USA
    Am J Physiol Heart Circ Physiol 293:H1978-86. 2007
    ..These changes in the type of adhesions may alter EC signaling pathways in tissue-engineered blood vessels...
  41. pmc Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour
    Mark R Morgan
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester, UK
    IUBMB Life 61:731-8. 2009
    ..By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated...
  42. pmc Clustering and internalization of integrin alphavbeta3 with a tetrameric RGD-synthetic peptide
    Lucie Sancey
    INSERM CRI U823, Cibles diagnostiques ou thérapeutiques et vectorisation de drogues dans les cellules tumorales, Institut Albert Bonniot, Grenoble Cedex 9, France
    Mol Ther 17:837-43. 2009
    ..These results strongly support the rationale for using multimeric RGD-peptides as targeting vectors for imaging, diagnosis, or therapy of cancers...
  43. pmc The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
    Gian Carlo Alghisi
    Division of Experimental Oncology, Centre Pluridisciplinaire d Oncologie CePO, Faculty of Biology and Medicine, University of Lausanne, and NCCR Molecular Oncology, ISREC, Epalinges, Switzerland
    PLoS ONE 4:e4449. 2009
    ..These effects are potentially relevant to the clinical use of cilengitide as anticancer agent...
  44. ncbi Multimeric system of 99mTc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor α(v)β(3) expression
    Enrique Morales-Avila
    Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Estado de México, Mexico
    Bioconjug Chem 22:913-22. 2011
    ..18 ± 0.57% ID/g. Micro-SPECT/CT images showed evident tumor uptake. (99m)Tc-AuNP-RGD demonstrates properties suitable for use as a target-specific agent for molecular imaging of tumor α(V)β(3) expression...
  45. pmc Impaired differentiation of osteoclasts in TREM-2-deficient individuals
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 198:645-51. 2003
    ..These results demonstrate a critical role for TREM-2 in the differentiation of mononuclear myeloid precursors into functional multinucleated OCs...
  46. ncbi RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis
    Fabienne Danhier
    Universite Catholique de Louvain, Pharmaceutics and Drug Delivery, Louvain Drug Research Institute, avenue E Mounier, 73 B1 73 12, B 1200, Brussels, Belgium
    Mol Pharm 9:2961-73. 2012
    ....
  47. ncbi Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:7708-18. 2005
    ..These results suggest that the up-regulated expression of alpha(v)beta3 contributes to the establishment of autocrine TGF-beta loop in scleroderma fibroblasts, and this integrin is a potent target for the treatment of scleroderma...
  48. pmc Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity
    Tomoko Hayashida
    Division of Kidney Diseases, Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 285:30741-51. 2010
    ..Together, our results indicate that decreasing β1 chain causes αvβ3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity...
  49. pmc PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2
    Haokao Gao
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Eur J Nucl Med Mol Imaging 39:683-92. 2012
    ....
  50. ncbi Translational implications of nongenomic actions of thyroid hormone initiated at its integrin receptor
    Paul J Davis
    Signal Transduction Laboratory, Ordway Research Institute, Albany, NY 12208, USA
    Am J Physiol Endocrinol Metab 297:E1238-46. 2009
    A thyroid hormone receptor on integrin alphavbeta3 that mediates cell surface-initiated nongenomic actions of thyroid hormone on tumor cell proliferation and on angiogenesis has been described...
  51. ncbi Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    Amy J Galliher
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Cancer Res 67:3752-8. 2007
    ....
  52. ncbi Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells
    Faith B Davis
    Ordway Research Institute, Inc, Albany, NY 12208, USA
    Cancer Res 66:7270-5. 2006
    ..the thyroid hormone L-thyroxine (T4) stimulates growth of cancer cells via a plasma membrane receptor on integrin alphaVbeta3. The contribution of this recently described receptor for thyroid hormone and receptor-based stimulation of ..
  53. pmc Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression
    Zi Bo Li
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA, USA
    Bioconjug Chem 18:1987-94. 2007
    ..This new (18)F labeling method based on click reaction may also be useful for radiolabeling of other biomolecules with azide groups in high yield...
  54. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    ..PAI-1 induces the internalization of urokinase plasminogen activator/receptor and integrin alphavbeta3 from the cell surface...
  55. ncbi Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
    Marcel L Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Res 62:6146-51. 2002
    ..Injection of (90)Y-DOTA-E-[c(RGDfK)](2) induced a significant delay in tumor growth. Potentially, these peptides can be used for peptide receptor radionuclide imaging as well as therapy...
  56. ncbi Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 34:267-73. 2007
    ..In this study the alpha(v)beta(3) binding characteristics of an (111)In-labelled monomeric, dimeric and tetrameric RGD analogue were compared...
  57. pmc Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers
    Zhaofei Liu
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging 9:21-9. 2010
    b>Integrin alphavbeta3 plays great roles in tumor angiogenesis, invasion, and metastasis...
  58. pmc Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells
    Paul A Dayton
    Department of Biomedical Engineering, UC Davis, CA 95616, USA
    Mol Imaging 3:125-34. 2004
    ....
  59. pmc microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)
    Zhanhong Wu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    J Nucl Med 48:1536-44. 2007
    ..Here we report an example of (18)F-labeled tetrameric RGD peptide for PET of alpha(v)beta(3) expression in both xenograft and spontaneous tumor models...
  60. ncbi Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells
    Sylvie Maubant
    Centre National de Recherche Scientifique, Unité Mixte de Recherche CNRS UMR 6543, Centre Antoine Lacassagne, Nice, France
    Blood 108:3035-44. 2006
    ..Altogether, these findings have important implications for the development of this class of antiangiogenics...
  61. pmc Kindlin-2 (Mig-2): a co-activator of beta3 integrins
    Yan Qing Ma
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Cell Biol 181:439-46. 2008
    ..Our results thus identify kindlin-2 as a novel regulator of integrin activation; it functions as a coactivator...
  62. ncbi Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB
    Sylvie Monferran
    Institut Claudius Regaud, INSERMU563, Department of Oncogenesis, Signalling and Therapeutic Innovation, France
    Int J Cancer 123:357-64. 2008
    ....
  63. pmc Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography
    Jason E Streeter
    Joint Department of Biomedical Engineering, University of North Carolina North Carolina State University, Chapel Hill, NC 27599, USA
    Mol Imaging 10:460-8. 2011
    ..3D MI, including volumetric analysis of inter- and intra-animal targeting, provides a thorough way of characterizing angiogenesis and will be a more robust assessment technique for the future of MI...
  64. ncbi Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells
    Shr Jeng Leu
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 277:46248-55. 2002
    ....
  65. ncbi Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models
    Jeffrey M Albert
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Radiat Oncol Biol Phys 65:1536-43. 2006
    ..Radiotherapy also inhibits tumor growth and affects vasculature. We explored the combination of integrin antagonist Cilengitide (EMD 121974) and ionizing radiation...
  66. pmc Integrin activation dynamics between the RGD-binding site and the headpiece hinge
    Eileen Puklin-Faucher
    Department of Materials, Laboratory of Biologically Oriented Materials, ETH, Zurich CH 8049, Switzerland
    J Biol Chem 284:36557-68. 2009
    ..become strengthened under force), as well as earlier evidence that Ca(2+) at the ADMIDAS results in lower binding affinity, these simulations provide a common structural model for the dynamic process by which integrins become activated...
  67. ncbi Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe
    Chun Li
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nucl Med Biol 33:349-58. 2006
    ..In this study, we synthesized and characterized a dual-labeled RGD (Arg-Gly-Asp) peptide and compared nuclear and optical images obtained with this agent...
  68. pmc Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
    ..Our studies demonstrate that alpha(V)beta(3) is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)...
  69. pmc Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha
    Guoying Jiang
    Department of Biological Sciences, Columbia University, New York, New York 11027, USA
    Biophys J 90:1804-9. 2006
    ..We suggest that RPTPalpha and alphavbeta3 at the leading edge are critical elements for sensing FN matrix rigidity possibly through SFK activation at the edge and downstream signaling...
  70. ncbi Improved tumor targeting of radiolabeled RGD peptides using rapid dose fractionation
    Marcel Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Biother Radiopharm 19:399-404. 2004
    ..In conclusion, dose fractionation resulted in higher radiation doses. However, therapeutic efficacy of the radiolabeled peptide was not significantly improved by dose fractionation...
  71. ncbi Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells
    Tzu Hsiu Lai
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    J Cell Physiol 218:334-42. 2009
    ..Taken together, our results indicate that lung derived-SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway...
  72. pmc Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature
    Oliver Schnell
    Department of Neurosurgery, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Brain Pathol 18:378-86. 2008
    ....
  73. ncbi Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated
    Hung Yun Lin
    Signal Transduction Laboratory, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Carcinogenesis 29:62-9. 2008
    The stilbene resveratrol (RV) initiates p53-dependent apoptosis via plasma membrane integrin alphaVbeta3 in human cancer cells. A thyroid hormone (L-thyroxine, T(4)) membrane receptor also exists on alphaVbeta3...
  74. ncbi Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting
    Marcel Janssen
    Department of Nuclear Medicine and Obstetrics and Gynecology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Biother Radiopharm 17:641-6. 2002
    ..Furthermore, kidney retention of the dimeric peptide was higher than that of the monomeric peptide...
  75. ncbi Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide
    Xiaoyuan Chen
    University of Southern California, Los Angeles, USA
    Mol Imaging 3:96-104. 2004
    ..5 +/- 0.8. The synergistic effect of polyvalency and improved pharmacokinetics may be responsible for the superior imaging characteristics of [18F]FB-E[c(RGDyK)]2...
  76. ncbi MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, MB Eindhoven, The Netherlands
    FASEB J 19:2008-10. 2005
    ....
  77. ncbi Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3
    Dilantha B Ellegala
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 108:336-41. 2003
    ..We hypothesized that contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins expressed on the neovascular endothelium could be used to image angiogenesis...
  78. pmc Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers
    Lijun Wang
    School of Health Sciences, Purdue University, Indiana 47907, USA
    Mol Pharm 6:231-45. 2009
    ..Thus, (99m)Tc-3PEG(4)-dimer is a very promising radiotracer for the early detection of integrin alpha(v)beta(3)-positive tumors, and may have the potential for noninvasive monitoring of tumor growth or treatment efficacy...
  79. ncbi Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging
    Shuang Liu
    School of Health Sciences, Purdue University, Civil Engineering Building Room 1275, 550 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Mol Pharm 3:472-87. 2006
    b>Integrin alphavbeta3 plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence...
  80. ncbi Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 108:2270-4. 2003
    ..The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to plaque instability, however, cannot be detected directly with any current diagnostic modality...
  81. ncbi Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice
    Iina Laitinen
    Nuklearmedizinische Klinik der TU Muenchen, Technische Universitaet Muenchen, Munich, Germany
    Circ Cardiovasc Imaging 2:331-8. 2009
    ..Therefore, we evaluated (18)F-galacto-RGD for imaging vascular inflammation by studying its uptake into atherosclerotic lesions of hypercholesterolemic mice in comparison to deoxyglucose...
  82. ncbi Imaging of integrin alphavbeta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Metastasis Rev 27:631-44. 2008
    The integrin alphavbeta3 plays an important role in angiogenesis and tumor metastasis. It is expressed on activated endothelial cells as well as some tumor cells...
  83. pmc The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling
    Jun Saegusa
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    J Biol Chem 284:24106-14. 2009
    It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling...
  84. pmc Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
    Bing Hao Luo
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:2403-8. 2003
    ....
  85. ncbi RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties
    Annette M Lechner
    Division of Clinical Chemistry and Clinical Biochemistry in the Department of Surgery, Ludwig Maximilians University and Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 281:39588-97. 2006
    ..Our results provide for the first time evidence that the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components...
  86. ncbi Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging
    Patrick M Winter
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5838-43. 2003
    ....
  87. ncbi Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
    Helen Hutchings
    GDR CNRS 1927 Angiogenese and UMR CNRS 5089, Institut de Pharmacologie et Biologie Structurale, Toulouse, France
    FASEB J 17:1520-2. 2003
    ..We have thus determined a new VEGF receptor-independent role for immobilized VEGF in supporting cell adhesion and survival through interactions with integrins...
  88. ncbi Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway
    Yi Chin Fong
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Lung Cancer 64:263-70. 2009
    ..Taken together, these results suggest that OPN acts through alphavbeta3 integrin, which in turn activates the FAK, PI3K, Akt, ERK and NF-kappaB pathways, contributing to the migration of lung cancer cells...
  89. ncbi Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion
    Vadim Pedchenko
    Division of Nephrology, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:2772-80. 2004
    ..Therefore, the RGD site, in addition to non-RGD motifs, may contribute to the mechanisms of endothelial cell adhesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain...
  90. ncbi Monitoring glioma growth and tumor necrosis with the U-SPECT-II/CT scanner by targeting integrin αvβ3
    Guoqiang Shao
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Imaging 12:39-48. 2013
    ..95. (99m)Tc-3P-RGD(2) SPECT/CT is excellent for monitoring α(v)β(3) expression and tumor necrosis during tumor growth and may become a screening tool for patient selection before anti-α(v)β(3) therapy...
  91. pmc Cleaved high molecular weight kininogen inhibits tube formation of endothelial progenitor cells via suppression of matrix metalloproteinase 2
    Y Wu
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Thromb Haemost 8:185-93. 2010
    ..In this study, our results provided the first evidence that HKa is able to target EPCs and inhibits their tube forming capacity...
  92. ncbi RGD-peptide lunasin inhibits Akt-mediated NF-κB activation in human macrophages through interaction with the αVβ3 integrin
    Anthony Cam
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Mol Nutr Food Res 56:1569-81. 2012
    ....
  93. ncbi Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness
    Alexandre Puissant
    INSERM U1065, Team Cell Death, Differentiation, Inflammation and Cancer, Nice, France
    J Mol Cell Biol 4:207-20. 2012
    ....
  94. pmc Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
    Daniel C Worth
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 189:369-83. 2010
    ..These data demonstrate a novel mechanism by which alphavbeta3 integrin acts to locally suppress beta1 integrin activation and regulate protrusion, adhesion dynamics, and persistent migration...
  95. pmc Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalency
    Shuang Liu
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Bioconjug Chem 20:2199-213. 2009
    ..Improvement of tumor uptake and tumor-to-background ratios is important for early detection of integrin alpha(v)beta(3)-positive tumors and/or noninvasive monitoring of therapeutic efficacy of antiangiogenic therapy...
  96. ncbi CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways
    Chun Yin Huang
    Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yun Lin County, Taiwan
    Biochem Pharmacol 77:794-803. 2009
    ..Taken together, our results suggest that CCL5 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activation of alphavbeta3 integrin and contributing to the migration of human lung cancer cells...
  97. ncbi Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity
    Joel Raborn
    Department of Biological Sciences, 202 Life Sciences Building, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Cell Biochem 113:1190-7. 2012
    ..Our study suggests that the variation of this residue contributes to the different ligand binding affinities and adhesion abilities among different integrin families...
  98. ncbi Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB
    Donald L Courter
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:12145-51. 2005
    ..Together, these experiments indicate that the C terminus of beta3 and Src activity are required for integrin alpha(v)beta3-mediated nuclear factor-kappaB activation...
  99. ncbi Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src
    Stephan Huveneers
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 67:2693-700. 2007
    ..These findings delineate a novel integrin-controlled oncogenic signaling cascade and suggest that the interaction of alpha(v)beta(3) with c-Src may represent a novel target for therapeutic intervention...
  100. pmc c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin
    Jingying Xu
    Department of Pediatrics, Neil Bogart Memorial Laboratories, Division of Hematology Oncology, Saban Research Institute at Childrens Hospital Los Angeles, USA
    Blood 115:2709-18. 2010
    ..Thus, endogenous c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5 or by LatB-induced disruption of F-actin...
  101. pmc Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides
    Jurgen K Willmann
    Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, California 94305 5105, USA
    J Nucl Med 51:433-40. 2010
    ....

Research Grants62

  1. Investigation of the VEGFR/Integrin cytoplasmic domains interaction.
    Olga Vinogradova; Fiscal Year: 2011
    ..Moreover, our structural approach should contribute to the development of new therapeutic agents designed to inhibit integrin (and other receptors) cytoplasmic domain protein-protein interactions. ..
  2. Integrin Signaling In Vascular Cells
    Susan Smyth; Fiscal Year: 2009
    ..The objective of this application is to understand how integrin alphaVbeta3-dependent signaling influences SMC growth and migration...
  3. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ....
  4. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2004
    ..Third, the crystal structure of the extracellular domain of integrin alphavBeta3 has just been published, providing a major breakthrough and an opportunity to design incisive approaches to ..
  5. IN VIVO/IN VITRO STUDIES OF BONE ACIDIC GLYCOPROTEIN-75
    JEFFREY GORSKI; Fiscal Year: 1991
    ....
  6. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 2001
    ..These studies should provide important information about the mechanisms by which asbestos induces apoptosis in mesothelial cells and the role of asbestos-induced apoptosis in asbestos-induced pathology. ..
  7. Integrin alpha v beta 3 promotes resistance to EGF receptor inhibitors
    David A Cheresh; Fiscal Year: 2013
    ..If successful, these studies will support the continued use of EGFR-targeted therapies in the clinic, and offer novel strategies to improve response to such therapies once tumors acquire resistance. ..
  8. REGULATION OF CELL MIGRATION IN VASCULAR REMODELING
    Eric Howard; Fiscal Year: 2002
    ..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
  9. INTEGRINS AND PMN MOTILITY
    WILLIAM HENDEY; Fiscal Year: 2000
    ..Finally, relationship between beta2 phosphorylation and beta3-mediated attachment or detachment will be assessed. ..
  10. IMMUNOCHEMICAL ANALYSIS OF LIGAND-RECEPTOR INTERACTION
    ANDREW FRELINGER; Fiscal Year: 1990
    ..Finally, antibodies and peptides developed in the course of this work may useful diagnostic or therapeutic anti- thrombotic agents...
  11. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  12. Molecular Analysis fo Borrelia P66-Integrin Binding
    Jenifer Coburn; Fiscal Year: 2009
    ..In Aim 3 we will investigate how mammalian cell biology is affected by B. burgdorferi P66 attachment to integrin alphavbeta3. Immunofluorescence microscopy, immunoprecipitation, immunoblotting, and microarrays will be used to ..
  13. STUDIES OF ANTAGONISTS TO INTEGRIN ALPHA V BETA 3
    RALPH MATTERN; Fiscal Year: 2001
    ..1 million people a year and is the leading cause of blindness in the under 55 age group. ..
  14. DISTRIBUTION AND FUNCTION OF THE INTEGRIN ANDYB8
    Stephen Nishimura; Fiscal Year: 1999
    ....
  15. PEPTIDE TARGETING OF IL12 TO MALIGNANT ENDOTHELIUM
    STUART HELFAND; Fiscal Year: 2002
    ..abstract_text> ..
  16. Fogarty International Research Collaboration Award
    Keith Burridge; Fiscal Year: 2004
    ..This collaborative grant is aimed at understanding how cell-cell interaction mediated by Thy-1 binding to integrin alphavBeta3 activates RhoA, whether integrin signaling triggered by Thy-1 binding stimulates cell migration and what ..
  17. FUNCTION OF THE VITRONECTIN RECEPTOR OF HUMAN RPE
    Shintaro Suzuki; Fiscal Year: 1991
    ..Such data will also assist us in comprehending the adhesion properties of RPE cells and their function...
  18. Transcriptional Regulation of Osteoclasts by Mitf
    Yi Ling Lin; Fiscal Year: 2005
    ..abstract_text> ..
  19. Methods to Understand Transmembrane Helical Association
    Chad Tatko; Fiscal Year: 2006
    ..Incorporation of high affinity binders into cells line with determine if they can be used as dominant negatives as cellular activity can be followed with monoclonal antibodies. ..
  20. ACTIVATION OF INTEGRINS ALPHA V BETA 3 & IIB BETA 3
    ANTHONY PELLETIER; Fiscal Year: 2000
    ....
  21. RETINA: SUBSTRUCTURE OF CONE PHOTORECEPTORS
    Gregory Hageman; Fiscal Year: 1999
    ....
  22. INDUCIBLE GENES IN ANGIOGENESIS AND TUMOR GROWTH
    LESTER LAU; Fiscal Year: 2003
    ..Cyr61 is a novel ligand of the integrin alphavbeta3, known to be important for angiogenesis...
  23. Role of L1-CAM in Melanoma Progression and Agiogenesis
    Anthony Montgomery; Fiscal Year: 2007
    ..Based on preliminary data, emphasis will be placed on interactions with the 'progression related' integrin alphavbeta3 and on the contribution of the mitogen-activated protein kinase (MAPK) pathway...
  24. TUMOR CELL INTERACTION WITH VASCULAR CELLS
    Brunhilde Felding Habermann; Fiscal Year: 1999
    ..with platelets promotes their arrest onto the vessel wall under flow; 2) binding of melanoma cell integrin alphavbeta3 to platelet integrin alphaIIbbeta3, via divalent or multivalent RGD-containing plasma proteins as molecular ..
  25. OSTEOPOROSIS APPROACH BASED ON BONE RESORPTION BLOCKADE
    Michael Rosenblatt; Fiscal Year: 2003
    ..abstract_text> ..
  26. ANGIOGENESIS & ALPHA V INTEGRINS IN RHEUMATOID ARTHRITIS
    Chris Storgard; Fiscal Year: 2003
    ..central to the pathophysiology of rheumatoid arthritis (RA), and anti-angiogenic therapy targeting vascular integrin alphavbeta3, a crucial effector of the angiogenic process, may provide a novel approach to the treatment of this ..
  27. STRUCTURE/FUNCTION OF BLOOD PLATELET GPIIB-IIIA
    JOSEPH LOFTUS; Fiscal Year: 1999
    ..Major concerns from last review were about interpreting data from loss-of-function mutation, and the need to establish feasibility of methods that had been proposed. ..
  28. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..
  31. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  32. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  33. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  34. Pathogenesis of ADPKD-role of the transcriptional modulator TAZ
    M Amin Arnaout; Fiscal Year: 2010
    ..The results from these studies will help define a novel pathway regulating the expression level of PKDl and hence contributing to the renal and extrarenal manifestationsofADPKD. ..
  35. THE PHAGOCYTE MEMBRANE
    M Amin Arnaout; Fiscal Year: 2009
    ..3) Identify novel intermediates that regulate inside-out activation of integrins using genetic (RNAi), immunochemical and biochemical approaches. ..
  36. Targeting Metastatic Breast Cancer with Human Antibodies
    Brunhilde Felding Habermann; Fiscal Year: 2009
    ..in vivo, showed that a metastatic subset of human breast cancer cells expresses an adhesion receptor, the integrin alphavbeta3, in a constitutively activated functional form...
  37. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  38. Structure-function of the Proangiogenic Integrin alphaVb
    M Amin Arnaout; Fiscal Year: 2006
    ....
  39. Metabolomic Analysis of Type 1 Diabetic Nephropathy
    M Amin Arnaout; Fiscal Year: 2005
    ..In this manner, we hone to identify potential metabolomic biomarkers worthy of subsequent validation. ..
  40. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  42. Integrin Activation in Breast Cancer Metastasis
    Brunhilde Felding Habermann; Fiscal Year: 2006
    ..b>Integrin alphavbeta3 is here defined as activated, if it supports breast cancer cell interaction with platelets during blood ..
  43. IVIS 200 Imaging System
    Brunhilde Felding Habermann; Fiscal Year: 2005
    ..abstract_text> ..
  44. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  45. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
    ..abstract_text> ..
  46. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
    ..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..
  47. Imaging Alpha (v)beta(3) Integrin Expression
    Xiaoyuan Chen; Fiscal Year: 2006
    ..abstract_text> ..
  48. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007
    ..Completion of this proposal will aid in the design and planning of clinical trials that will study the use of serial annexin V imaging as a non-invasive marker of cellular injury and therapeutic efficacy. ..
  49. Molecular Imaging of Angiogenesis by MRI
    Gregory Lanza; Fiscal Year: 2007
    ..Apply mathematical models of tissue compartmentalization to determine the contributions of target binding and vascular permeability to MRI signal enhancement. ..
  50. MicroPET and NIR Fluorescence Imaging Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2004
    ..b>Integrin alphavbeta3, which is not readily detectable in quiescent vessels but becomes highly expressed in angiogenic vessels ..
  51. MACAQUE IN VITRO IMPLANTATION MODEL
    GORDON DOUGLAS; Fiscal Year: 2004
    ..Specific Aim 3 will use neutralizing antibodies and immobilized recombinant chemokines to characterize the role of chemokines in regulating expression of trophoblast migratory phenotypic markers and blastocyst development. ..
  52. INTEGRIN ANTAGONISTS IN GLIOMA BIOLOGY, IMAGING, THERAPY
    Tom Mikkelsen; Fiscal Year: 2003
    ..abstract_text> ..
  53. Radiolabeled Peptides for Imaging Tumor Angiogenesis
    LINDA KNIGHT; Fiscal Year: 2004
    ..A future benefit of this approach is the potential for targeted radiotherapy of tumors by labeling the same disintegrin with a therapeutic radionuclide. ..
  54. I-DOMAIN CONTAINING INTEGRIN/LIGAND INTERACTIONS
    Yoshikazu Takada; Fiscal Year: 2002
    ..These studies could potentially lead to the design of inhibitors or activators that could be useful for preventing cancer metastasis, rejection of a transplanted organ, or other medical conditions. ..
  55. KININOGEN/UROKINASE RECEPTORS IN TUMOR ANGIOGENESIS
    Robert Colman; Fiscal Year: 2008
    ..Successful completion of this proposal could result in the development of new agents for the treatment of cancer is characterized by tumor-induced angiogenesis. ..
  56. Adenovirus Modulation of Lacrimal Gland Function
    SARAH HAMM ALVAREZ; Fiscal Year: 2005
    ..The studies proposed here will be essential in evaluating the feasibility of ocular gene therapy using Ad-derived materials and in improving the safety of such delivery systems. ..
  57. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. Biophysical Properties of Membranes: Lipid-Protein Bonds
    Michael Sheetz; Fiscal Year: 2006
    ..abstract_text> ..
  59. Gene transfer of antibodies targeting tumor angiogenesis
    Carlos Barbas; Fiscal Year: 2006
    ..In addition, they are designed to facilitate a faster transition from preclinical to clinical development based on (i) cross-reactivity with human and mouse antigen and (ii) established antibody humanization strategies. ..
  60. THE NHLBI-BAY AREA FUNCTIONAL GENOMICS CONSORTIUM
    Dean Sheppard; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Component 4-6). ..