platelet membrane glycoproteins

Summary

Summary: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.

Top Publications

  1. ncbi Platelet-collagen interaction: is GPVI the central receptor?
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine Versbacher, Wurzburg, Germany
    Blood 102:449-61. 2003
  2. ncbi Trafficking and function of the tetraspanin CD63
    Maaike S Pols
    Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Exp Cell Res 315:1584-92. 2009
  3. ncbi The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis
    Guy A Zimmerman
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Crit Care Med 30:S294-301. 2002
  4. ncbi Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin
    P M Sincock
    Department of Medicine, The University of Adelaide, Australia
    J Histochem Cytochem 45:515-25. 1997
  5. pmc Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection
    Danielle G Souza
    Immunopharmacology, Departmento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Proc Natl Acad Sci U S A 106:14138-43. 2009
  6. ncbi Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor
    Denis J Dupre
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 278:48228-35. 2003
  7. ncbi TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    J Thromb Haemost 9:163-72. 2011
  8. ncbi ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 10:1133-41. 2012
  9. ncbi Platelet receptor signaling in thrombus formation
    David Stegner
    Chair of Vascular Medicine, University Hospital and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    J Mol Med (Berl) 89:109-21. 2011
  10. ncbi Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
    B A Mannion
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:2039-47. 1996

Research Grants

Detail Information

Publications287 found, 100 shown here

  1. ncbi Platelet-collagen interaction: is GPVI the central receptor?
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine Versbacher, Wurzburg, Germany
    Blood 102:449-61. 2003
    ..This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis...
  2. ncbi Trafficking and function of the tetraspanin CD63
    Maaike S Pols
    Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Exp Cell Res 315:1584-92. 2009
    ..In this review we discuss the latest insights in CD63 trafficking and its emerging function as a transport regulator of its interaction partners. Finally, the involvement of CD63 in cancer will be discussed...
  3. ncbi The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis
    Guy A Zimmerman
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Crit Care Med 30:S294-301. 2002
    ..To review the platelet-activating factor (PAF) signaling system, its regulation, and its dysregulation in acute inflammation and thrombosis and in syndromes that involve these cascades, including sepsis...
  4. ncbi Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin
    P M Sincock
    Department of Medicine, The University of Adelaide, Australia
    J Histochem Cytochem 45:515-25. 1997
    ..However, the lack of co-localization of these antigens in other tissues also implies distinct roles for these molecules...
  5. pmc Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection
    Danielle G Souza
    Immunopharmacology, Departmento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Proc Natl Acad Sci U S A 106:14138-43. 2009
    ..PAFR antagonists are disease-modifying agents in experimental dengue infection...
  6. ncbi Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor
    Denis J Dupre
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 278:48228-35. 2003
    ..Our results indicate that PAFR degradation can occur via both the proteasome and lysosomal pathways and ligand-stimulated degradation is ubiquitin-dependent...
  7. ncbi TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    J Thromb Haemost 9:163-72. 2011
    ....
  8. ncbi ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 10:1133-41. 2012
    ....
  9. ncbi Platelet receptor signaling in thrombus formation
    David Stegner
    Chair of Vascular Medicine, University Hospital and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    J Mol Med (Berl) 89:109-21. 2011
    ..This review summarizes the most important receptor systems and signaling mechanisms involved in platelet activation and thrombus formation with special focus on recent discoveries...
  10. ncbi Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
    B A Mannion
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:2039-47. 1996
    ..Thus, CD81 and other transmembrane-4 superfamily members may participate in functionally relevant interactions with alpha 4 beta 1 and other integrins...
  11. ncbi Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration
    P F Penas
    Departments of Dermatology and Immunology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    J Invest Dermatol 114:1126-35. 2000
    ..Together these results indicate that tetraspanin-integrin complexes might be involved in transient adhesion and integrin recycling during keratinocyte migration, as well as in intercellular recognition...
  12. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  13. ncbi Spatially distinct production of reactive oxygen species regulates platelet activation
    Nadia Bakdash
    Center for Vascular and Inflammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Free Radic Biol Med 45:158-66. 2008
    ..Thus, targeting ROS with site-specific antioxidants may differentially regulate platelet activation via thrombin or collagen...
  14. ncbi Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium
    Johan Bylund
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Biol Chem 278:30578-86. 2003
    ..Further, phosphatidylinositol 3-kinase, mitogen-activated protein kinase, and MEK all participated in the generation of second messengers from the reactivated receptors...
  15. ncbi Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus
    C I Jones
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Thromb Haemost 5:1756-65. 2007
    ..Unraveling the complex relationship between sequence variation and platelet phenotype requires accurate and reproducible measurement of platelet response...
  16. ncbi Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo
    Steffen Massberg
    Klinikum rechts der Isar, 1 Medizinische Klinik, Technische Universitat Munchen, D 81675 Munchen, Germany
    FASEB J 18:397-9. 2004
    ..These findings further substantiate the critical role of the collagen receptor GPVI in the initiation of thrombus formation at sites of vascular injury and identify soluble GPVI as a promising antithrombotic strategy...
  17. pmc A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
    M Moroi
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    J Clin Invest 84:1440-5. 1989
    ..The patient's platelets did not bind to types I and III collagen fibrils. Our results suggest that GPVI functions as a collagen receptor...
  18. ncbi Platelets: signaling cells in the immune continuum
    Andrew S Weyrich
    Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, 15 North 2030 East, Room 4220, Salt Lake City, Utah 84112, USA
    Trends Immunol 25:489-95. 2004
    ..This Review is the third in a series on interactions between haemostasis and inflammation...
  19. ncbi Pivotal role for platelet-activating factor receptor in CD36 expression and oxLDL uptake by human monocytes/macrophages
    Francisco J O Rios
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Cell Physiol Biochem 27:363-72. 2011
    ..These results suggest that oxLDL interacts with PAFR in macrophages to increase CD36 expression and oxLDL uptake. Whereas pharmacological intervention at the level of PAFR would be beneficial in atherosclerosis remains to be determined...
  20. pmc Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
    Amy M Booth
    Department of Biological Chemistry and 2Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 172:923-35. 2006
    ..In support of this, we find that Jurkat T cells direct the key budding factor of HIV, HIV Gag, to these endosome-like domains of plasma membrane and secrete HIV Gag from the cell in exosomes...
  21. ncbi Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets
    Peter A Smethurst
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 282:1296-304. 2007
    ..Furthermore, we propose that the (GPO)4 motif can support simultaneous binding of two glycoprotein VI molecules, in either a parallel or anti-parallel stacking arrangement, which could play an important role in activation of signaling...
  22. ncbi The growing complexity of platelet aggregation
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Blood 109:5087-95. 2007
    ....
  23. pmc A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, D 80636 München, Germany
    J Exp Med 197:41-9. 2003
    ....
  24. ncbi CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells
    M J Metzelaar
    Department of Haematology, University Hospital Utrecht, The Netherlands
    J Biol Chem 266:3239-45. 1991
    ..CD63 was not related to the lysosomal glycoprotein family but contained the putative lysosomal targeting signal Gly-Tyr in its short cytoplasmic tail...
  25. pmc Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor
    Qiwei Zhang
    Department of Dermatology, H B Wells Center for Pedoatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 115:2855-61. 2005
    ..These findings show a novel mechanism by which staphylococcal infections can inhibit Th1 reactions and thus worsen Th2 skin diseases, such as atopic dermatitis...
  26. ncbi Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor
    Denis J Dupre
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
    Cell Signal 19:2068-79. 2007
    ..These results indicate that although both agonists and inverse agonists induce receptor PAFR down-regulation, this may be accomplished through different signal transduction and trafficking pathways...
  27. ncbi Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration
    T William Axelrad
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    FASEB J 18:568-70. 2004
    ..6:1, approximating the hypothesized ideal ratio of 2:1 necessary for the conversion of proMMP2 to MMP2. Our data support the involvement of PAF in vascular endothelial cell migration and invasion...
  28. ncbi A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase
    F Berditchevski
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:2595-8. 1997
    ....
  29. ncbi Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells
    Sang Hun Shin
    Medical Research Center for Ischemic Tissue Regeneration, Medical Research Institute, School of Medicine, Pusan National University, Gyeongsangnam do, Republic of Korea
    Cell Physiol Biochem 26:689-98. 2010
    ..Oxidized low density lipoprotein (oxLDL) is involved in the development of vascular diseases. Platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glyero-3-phosphorylcholine) is a key component of oxLDL...
  30. ncbi Characterization of a human cDNA that encodes a functional receptor for platelet activating factor
    R D Ye
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Biochem Biophys Res Commun 180:105-11. 1991
    ..Expression of the cloned cDNA in undifferentiated HL-60 cells devoid of endogenous PAF receptor resulted in specific and saturable binding of the PAF antagonist WEB 2086 with a dissociation constant of 30.7 nM...
  31. ncbi A CD63 mutant inhibits T-cell tropic human immunodeficiency virus type 1 entry by disrupting CXCR4 trafficking to the plasma membrane
    Takeshi Yoshida
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Traffic 9:540-58. 2008
    ..Our data suggest that CXCR4 trafficking can be modified in terms of its recruitment to the plasma membrane without enhancing the degradation or arresting vesicular transport of CXCR4...
  32. ncbi Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity
    Stéphane Loyau
    INSERM U698, CHU Xavier Bichat, 46 rue Henri Huchard 75877 Paris Cedex 18, France
    Arterioscler Thromb Vasc Biol 32:778-85. 2012
    ..The valence of GPVI on resting platelets needs to be clearly established because platelet avidity for collagen would be greater if GPVI is constitutively expressed as a dimer than as a monomer...
  33. ncbi The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines
    Tao Li
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:16614-21. 2003
    ..These studies provide evidence for a novel pathway whereby the epidermal PAF-R can augment chemotherapy-induced apoptotic effects through an NF-kappaB-dependent process...
  34. pmc Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats
    Caroline Belanger
    Faculty of Pharmacy, Universite de Montreal, Quebec, Canada
    Immunology 124:295-303. 2008
    ..Our results strongly support a role of both endogenous LTB(4) and PAF in regulating PMN trafficking to inflammatory sites in various experimental conditions...
  35. pmc Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63
    Nadya Latysheva
    CR UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Mol Cell Biol 26:7707-18. 2006
    ..Hence, our data indicate that syntenin-1 can counteract the AP-2-dependent internalization and identify this tandem PDZ protein as a new regulator of endocytosis...
  36. ncbi Intestinal epithelial cells secrete exosome-like vesicles
    G Van Niel
    INSERM E9925, Faculté Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    Gastroenterology 121:337-49. 2001
    ....
  37. ncbi Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase
    Elizabeth E Gardiner
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia, 3800
    Blood 104:3611-7. 2004
    ..This process may represent a potential mechanism to regulate GPVI-dependent platelet adhesion...
  38. pmc Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation
    L A Moraes
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK
    J Thromb Haemost 8:577-87. 2010
    ..Peroxisome proliferator-activated receptor-(gamma) (PPAR(gamma)) is expressed in human platelets although in the absence of genomic regulation in these cells, its functions are unclear...
  39. ncbi Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition
    K Horstrup
    Medizinische Universitatsklinik, Klinische Forschergruppe, Wurzburg, Germany
    Eur J Biochem 225:21-7. 1994
    ..It is proposed that the inhibition of glycoprotein IIb-IIIa induced by cyclic nucleotide involves cAMP-and cGMP-dependent protein-kinase-mediated VASP phosphorylation at Ser157...
  40. ncbi Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases
    E E Gardiner
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC Australia
    J Thromb Haemost 5:1530-7. 2007
    ..Platelet glycoprotein (GP)VI that binds collagen, and GPIb-IX-V that binds von Willebrand factor, initiate thrombus formation...
  41. ncbi Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation
    Caroline Poisson
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Canada
    J Immunol 183:2747-57. 2009
    ..In conclusion, PAFR appears to localize within caveolae or lipid rafts in different cell types, and this location may be important for specific signaling events...
  42. pmc Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    J Exp Med 193:459-69. 2001
    ....
  43. ncbi Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation
    M Torti
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 274:13690-7. 1999
    ..Our results indicate that translocation of Rap1B and Rap2B to the cytoskeleton is regulated by tyrosine kinases and suggest a novel role for the FcgammaII receptor in the mechanism of platelet activation by vWF...
  44. ncbi Increased microvascular permeability in the hamster cheek pouch induced by oxidized low density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins
    E Svensjo
    Laboratório de Imunologia Molecular, Instituto Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro
    Inflamm Res 52:215-20. 2003
    ..Oxidized low-density lipoproteins (oxLDL) and protein fractions obtained by size exclusion chromatography of oxLDL were tested for vascular permeability effects on topical application to the hamster cheek pouch...
  45. ncbi Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    B Savage
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, La Jolla, California 92037, USA
    Cell 84:289-97. 1996
    ..This eventually allows activated alpha IIb beta 3 to arrest platelets onto vWF under conditions not permissive of direct binding to fibrinogen. The coupling of these different functions may be crucial for thrombogenesis...
  46. ncbi Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding
    Mohammad Al-Tamimi
    Department of Immunology, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Platelets 20:75-82. 2009
    ..In conclusion, this analysis of anti-GPVI mAbs provides useful tools for studying the functional role of platelet GPVI...
  47. pmc Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain
    Shigeo Hasegawa
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 5:e10467. 2010
    ..However, lipid mediators downstream of cPLA(2) activation to produce tactile allodynia remain to be determined...
  48. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
    ..Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases...
  49. ncbi Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology
    Sophie Fillon
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 177:6182-91. 2006
    ..Thus, PAFr shepherds phosphorylcholine-containing bacterial components such as the cell wall into host cells from where the response ranges from quiescence to severe pathophysiology...
  50. pmc In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53
    Magdalena Deneka
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 177:329-41. 2007
    ..These results indicate that, in macrophages, HIV-1 exploits a previously undescribed intracellular plasma membrane domain to assemble infectious particles...
  51. pmc Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    EMBO J 20:2120-30. 2001
    ..These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential...
  52. ncbi Phagocytosis of apoptotic and necrotic thymocytes is inhibited by PAF-receptor antagonists and affects LPS-induced COX-2 expression in murine macrophages
    Soraya Imon de Oliveira
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1730, 05508 900 Sao Paulo, Brazil
    Prostaglandins Other Lipid Mediat 80:62-73. 2006
    ..These findings indicate that apoptotic and necrotic cells share common ligands with PAF and oxLDL and suggest the involvement of PAF-like receptors in the enhanced clearance of these cells...
  53. ncbi Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
    H K Nieuwenhuis
    Nature 318:470-2. 1985
    ..We now report a defect of the platelet plasma membrane glycoprotein composition in a patient whose platelets are totally unresponsive to collagen...
  54. ncbi Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpain
    P Siljander
    Wihuri Research Institute, and the Electron Microscopy Unit, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 21:618-27. 2001
    ..We conclude that the procoagulant response evoked by GPVI stimulation is potentiated by platelet adhesion. The sequential activation of p38 MAPK and calpain appears to regulate procoagulant membrane blebbing but not PS exposure...
  55. pmc Identification of a major GpVI-binding locus in human type III collagen
    Gavin E Jarvis
    Departments of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 111:4986-96. 2008
    ..These data indicate that the ability of a triple-helical peptide to bind GpVI is not solely determined by the presence or spatial arrangement of these OGP/GPO motifs within the peptides...
  56. ncbi Platelet-activating factor receptor
    Zen Ichiro Honda
    Department of Allergy, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biochem 131:773-9. 2002
    ..Establishment of PAFR(-/-) mice confirmed that the PAF receptor is responsible for pro-inflammatory responses, but that its roles in other settings remain to be clarified...
  57. ncbi Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
    ..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
  58. pmc NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
    M Scatena
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Cell Biol 141:1083-93. 1998
    ..In contrast, inhibition of MEK and PI3-kinase did not affect osteopontin-induced NF-kappaB activation. These studies identify NF-kappaB as an important signaling molecule in alphavbeta3 integrin-mediated endothelial cell survival...
  59. ncbi PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
    P J Newman
    The Blood Center of Southeastern Wisconsin, Milwaukee 53233
    Science 247:1219-22. 1990
    ..This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events...
  60. ncbi Platelet-activating factor and related lipid mediators
    S M Prescott
    The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Annu Rev Biochem 69:419-45. 2000
    ....
  61. ncbi Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
    Hassan Lemjabbar
    Biomedical Sciences Program, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California, USA
    Nat Med 8:41-6. 2002
    ..Unlike responses in macrophages, the epithelial-cell response to lipoteichoic acid does not require Toll-like receptor 2 or 4...
  62. ncbi Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, 42283 Wuppertal, Germany
    J Biol Chem 275:23998-4002. 2000
    ..These results strongly suggest that GPVI is the collagen receptor responsible for platelet activation in mice and demonstrate that the association with the FcRgamma chain is critical for its expression and function...
  63. ncbi Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody
    Peter A Smethurst
    Department of Haematology, University of Cambridge and National Blood Service Cambridge, Long Road, Cambridge, CB2 2PT, United Kingdom
    Blood 103:903-11. 2004
    ..Antibody 10B12 showed significantly reduced binding to the hD1D2-E59, and, on that basis, the GPVI:10B12 interface was modeled...
  64. ncbi Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor
    J Polgar
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    J Biol Chem 272:13576-83. 1997
    ....
  65. pmc von Willebrand factor binding to platelet GpIb initiates signals for platelet activation
    M H Kroll
    Houston Veterans Affairs Medical Center, Baylor College of Medicine, Texas 77030
    J Clin Invest 88:1568-73. 1991
    ..This signal then causes PKC activation and increases of [Ca2+]i, which promote platelet secretion and potentiate aggregation...
  66. ncbi Evidence that HIV budding in primary macrophages occurs through the exosome release pathway
    Deborah Greene Nguyen
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:52347-54. 2003
    ..These results strongly support the Trojan exosome hypothesis and its prediction that retroviral budding represents exploitation of a pre-existing cellular pathway of intercellular vesicle trafficking...
  67. ncbi CD82, and CD63 in thyroid cancer
    Zhouxun Chen
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Mol Med 14:517-27. 2004
    ..CD82 may serve as a prognostic marker of metastasis in thyroid cancer. Constitutive expression of CD63 may indicate that this factor does not play a direct role in thyroid carcinogenesis...
  68. ncbi Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA
    H Bito
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 221:211-8. 1994
    ..Isolation of rat PAF-receptor cDNA should facilitate further analysis of PAF-receptor function and pharmacology in diverse pathophysiological processes...
  69. ncbi PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation
    Giordano Pula
    Department of Pharmacology, School of Medical Sciences, University of Bristol, United Kingdom
    Blood 108:4035-44. 2006
    ..PKCdelta is therefore a critical negative regulator of filopodia, and hence platelet aggregation, through a functional interaction with the actin organizer VASP...
  70. ncbi Proteolysis of platelet receptors in humans and other species
    Jian L Qiao
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    Biol Chem 391:893-900. 2010
    ....
  71. ncbi Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
    Mohammad Al-Tamimi
    Monash University, Melbourne VI, Australia
    Stroke 42:498-500. 2011
    ..Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding...
  72. ncbi Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung
    Z Honda
    Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan
    Nature 349:342-6. 1991
    ..Our strategy involved gene expression in Xenopus laevis oocytes and electrophysiological detection of PAF-induced responses. Sequence analysis indicates that the receptor belongs to the superfamily of G protein-coupled receptors...
  73. ncbi Cell adhesion mechanisms in platelets
    David Varga-Szabo
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Zinklesweg 10, 97078 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 28:403-12. 2008
    ..This review summarizes the most important structural and functional properties of these adhesion receptors and briefly discusses their potential as targets for antithrombotic therapy...
  74. ncbi The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog
    D Kunz
    Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115
    J Biol Chem 267:9101-6. 1992
    ....
  75. pmc Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    EMBO J 16:133-42. 1997
    ..Furthermore, our findings provide new insights regarding the role of PAF in the morphogenesis of dermal tissues as well as the mitogenic activity of PAF and PAFR in vivo...
  76. ncbi Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
    T J Kovacsovics
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Biol Chem 270:11358-66. 1995
    ..PI 3-K stimulation downstream of GPIIb-IIIa engagement may provide positive feedback required to sustain active GPIIb-IIIa...
  77. pmc Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor
    T E O'Toole
    Research Institute of Scripps Clinic, La Jolla, California 92037
    Cell Regul 1:883-93. 1990
    ..Furthermore, they indicate that the activation state of alpha IIb beta 3 is a property of the receptor itself rather than of the surrounding cell membrane microenvironment...
  78. ncbi Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka Ken, Japan
    J Thromb Haemost 7:1347-55. 2009
    ..The platelet collagen receptor glycoprotein (GP) VI is suggested to exist as a dimer on the platelet surface, but no direct proof of the functional importance of dimer formation has been provided...
  79. ncbi A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder
    C Hermans
    Department of Haematology, Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Brussels, Belgium
    J Thromb Haemost 7:1356-63. 2009
    ..Remarkably, patients with a proven GPVI gene mutation have not yet been identified...
  80. ncbi Tetraspanin CD63 promotes targeting and lysosomal proteolysis of membrane-type 1 matrix metalloproteinase
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, 920 0934, Kanazawa, Japan
    Biochem Biophys Res Commun 304:160-6. 2003
    ..CD63 mutant lacking lysosomal targeting motif was unable to promote MT1-MMP degradation. These results suggest that CD63 regulates MT1-MMP by targeting to lysosomes...
  81. pmc Glycoprotein VI oligomerization in cell lines and platelets
    O Berlanga
    Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    J Thromb Haemost 5:1026-33. 2007
    ..Constitutive dimerization of GPVI has been proposed as being necessary for the interaction with collagen, although direct evidence of dimerization has not been reported in cell lines or platelets...
  82. ncbi A cell surface glycoprotein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491
    S Kitani
    Clinical Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 266:1903-9. 1991
    ..Therefore, mAb AD1 binds to a surface glycoprotein on RBL-2H3 cells sterically close to the Fc epsilon RI but distinct from the recognized subunits of the receptor...
  83. ncbi Selective blockade of glycoprotein VI clustering on collagen helices
    Marie N O'Connor
    Department of Haematology, University of Cambridge, Cambridge CB2 2PT, UK
    J Biol Chem 281:33505-10. 2006
    ..Together these results indicate that 1C3 inhibits clustering of the immunoglobulin-like domains of GPVI on collagen/CRPs, a conclusion that is supported by mapping the 1C3 epitope to the region including isoleucine 148 in D2...
  84. pmc Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e3793. 2008
    ..Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation...
  85. ncbi Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen
    M N O'Connor
    Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK
    J Thromb Haemost 4:869-73. 2006
    ..Recently, others have postulated the involvement of a portion of the first domain distant from the interdomain hinge as being involved in an extended collagen-binding site...
  86. ncbi Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion
    Stephanie M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan
    Platelets 19:32-42. 2008
    ..Our present results suggest that the physiological importance of type III collagen is to induce thrombus formation. Furthermore, these studies indicate that GPVI mainly binds to collagen types that can form large collagen fibrils...
  87. ncbi Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation
    O Berlanga
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 96:2740-5. 2000
    ..The results demonstrate that expression of GPVI is up-regulated along with the FcR gamma-chain during differentiation of megakaryocytes. (Blood. 2000;96:2740-2745)..
  88. ncbi Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane
    Jane F Arthur
    Department of Immunology, Monash University, Melbourne 3004, Australia
    J Biol Chem 282:30434-41. 2007
    ....
  89. ncbi Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets
    S P Jackson
    Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    J Biol Chem 269:27093-9. 1994
    ..Our results suggest that vWF binding to the platelet adhesion receptor glycoprotein Ib/IX can mediate activation and translocation of both tyrosine and lipid kinase(s) independent of other agonists...
  90. ncbi Expression of platelet-activating factor receptor: a novel prognosticator in patients with hepatocellular carcinoma following hepatectomy
    Dai Kitagawa
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncology 72:381-7. 2007
    ..Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the development of hepatocellular carcinoma (HCC) remains to be elucidated...
  91. ncbi Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications
    J A Lopez
    Gladstone Institute of Cardiovascular Disease, San Francisco, California
    J Biol Chem 267:10055-61. 1992
    ..Such a change may alter the susceptibility of platelets to shear-induced activation, a process that requires an interaction between glycoprotein Ib and von Willebrand factor...
  92. ncbi Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets
    Jane F Arthur
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Haemost 93:716-23. 2005
    ..A contribution of GPIb-IX-V to GPVI-induced platelet responses, and vice versa, therefore warrants further investigation...
  93. pmc Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy
    Hisako Hikiji
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Japan
    J Clin Invest 114:85-93. 2004
    ..Inhibition of PAF function might pave the way for a new strategy to prevent postmenopausal bone loss without disturbing osteoblast functions...
  94. ncbi Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor
    A Marilise Marrache
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Immunol 169:6474-81. 2002
    ..This study describes for the first time the nucleus as a putative organelle capable of generating PAF and expresses its receptor, which upon stimulation induces the expression of the proinflammatory gene COX-2...
  95. ncbi Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy
    Martin Hervé Beauchamp
    Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 43:3327-37. 2002
    ..To test whether platelet-activating factor (PAF) directly causes retinovascular endothelial cell (EC) death...
  96. ncbi Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1
    Giordano Pula
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol, UK
    Platelets 19:199-210. 2008
    ....
  97. ncbi GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism
    Simon Lockyer
    Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Thromb Res 118:371-80. 2006
    ..These observations clearly establish that blockade of GPVI may attenuate platelet-collagen interactions without adversely affecting the bleeding time...
  98. ncbi CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma
    K J Radford
    Oncology and Immunology Unit, David Maddison Clinical Sciences Building, Newcastle, New South Wales, Australia
    Biochem Biophys Res Commun 222:13-8. 1996
    ..The results suggest that CD63 is capable of forming multicomponent complexes with TM4SF members and beta 1 integrins on the surface of melanoma. These findings provide further insights into the function of CD63...
  99. ncbi Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
    S Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Prog Lipid Res 39:41-82. 2000
    ..This review also describes the phenotypes of these mutant mice and discusses them by referring to previously reported pharmacological and genetical data...
  100. ncbi GPVI and integrin alphaIIb beta3 signaling in platelets
    S P Watson
    Division of Medical Sciences, Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 3:1752-62. 2005
    ..The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed...
  101. ncbi Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Circulation 115:2323-30. 2007
    ..In the present study, we addressed the pathogenic role of GPIb, GPVI, and the aggregation receptor GPIIb/IIIa in experimental stroke in mice...

Research Grants62

  1. Carbohydrate-mediated platelet clearance
    KARIN MARIA HOFFMEISTER; Fiscal Year: 2013
    ..The hypothesis that systemic signals altered in the absence of Asgr1/2 regulate BM homeostasis will be solidified, and we will begin to identify these systemic factors. ..
  2. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2013
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  3. CELLULAR REGULATION OF BLOOD CLOTTING
    Marc Shuman; Fiscal Year: 1992
    ..with these antibodies will be used to determine whether GP 210 is complexed with other platelet membrane glycoproteins. b) the role of glycoprotein V in the pathogenesis of quinidine purpura...
  4. BIOSYNTHESIS NAD STRUCTURE OF THE FIBRINOGEN RECEPTOR
    Paul Bray; Fiscal Year: 1990
    ..b>Platelet membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa) exist as a heterodimeric complex in the platelet membrane and function ..
  5. CELLULAR CONSEQUENCES OF DEFECTIVE IIB AND IIIA GENES
    Paul Bray; Fiscal Year: 1993
    ..emphasis on the isolation of genomic sequences controlling the normal expression of the genes for platelet membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa), and (2) to analyze the cellular consequences of these defects...
  6. MOLECULAR GENETICS OF HUMAN PLATELET GLYCOPROTEINS
    Jose Lopez; Fiscal Year: 2000
    ..This knowledge should prove useful for the design of anti-thrombotic agents that work by blocking primary platelet adhesion. ..
  7. ROLE OF FACTOR XIII BINDING TO THE HEMOSTATIC PLUG
    Charles Greenberg; Fiscal Year: 1993
    ..Results from these studies may have direct application to the development of diagnostic and therapeutic agents which could benefit several thrombotic disorders including myocardial infraction, stroke and pulmonary embolization...
  8. THE IMMUNOGENICITY OF HUMAN PLATELET PROTEINS
    Thomas Kunicki; Fiscal Year: 1990
    ....
  9. GLYCOPROTEINS IIB AND IIIA IN PLATELETS AND NEUTROPHILS
    Lisa Jennings; Fiscal Year: 1991
    ..This study should provide information on the relationship of platelet antigens to the function of normal and abnormal leukocytes...
  10. THROMBOSIS ON BIOMATERIALS:ROLE OF VASCULAR COMPONENTS
    VINCENT TURITTO; Fiscal Year: 1991
    ..The mechanisms of growth of thrombotic deposits will also be investigated in nonstreamline (recirculation) flow by appropriately modifying the perfusion chambers and a theory for particle deposition will be developed...
  11. PLATELET MEMBRANE PROTEINS IN AGGREGATION
    David Phillips; Fiscal Year: 1993
    ....
  12. MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    YUET KAN; Fiscal Year: 1999
    ....
  13. MOLECULAR BASIS OF PLATELET FUNCTION
    Thomas Kunicki; Fiscal Year: 1992
    ....
  14. Molecular Genetics of Integrin Collagen Receptors
    Thomas Kunicki; Fiscal Year: 2007
    ..From a clinical standpoint, these studies will also reveal the impact of these gene differences on risk for adverse events in bleeding disorders such as Von Willebrand Disease. ..
  15. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas Kunicki; Fiscal Year: 2004
    ..The successful completion of the proposed studies will lead to a substantial increase in our understanding of the genetics and physiology of the platelet collagen receptor, GPVI. ..
  16. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2008
    ..abstract_text> ..
  17. METABOLISM OF PLATELET-ACTIVATING FACTOR
    Diana Stafforini; Fiscal Year: 2008
    ..III. Determine if deletion of PAF-AH alters the severity of necrotizing enterocolitis using animal models. IV. Test the hypothesis that PAF-AH alters atherosclerosis susceptibility using genetically engineered models. ..
  18. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  19. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  20. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  21. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  22. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  23. Transcriptional Regulation in Helicobacter pylori during Infection
    ANDRZEJ KREZEL; Fiscal Year: 2008
    ..pylori without resorting to potent side effect- inducing antibiotics that target universally shared biochemical pathways. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Postmenopause CHD risk: Platelet genes & hormone therapy
    Paul Bray; Fiscal Year: 2006
    ..abstract_text> ..
  25. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
    ..Taken together, these analyses will provide significant insights into the process and molecular parameters that control the IgE-mediated regulation of FceRI expression. ..
  26. SYNAPTIC PLASTICITY IN HIPPOCAMPAL EPILEPTOGENESIS
    Gary Clark; Fiscal Year: 2002
    ..Experiments are proposed to ascertain the role of these signal transduction mechanisms in the enhanced release of excitatory transmitter by PAF receptor activation. ..
  27. ENDOTHELIN AND INTRAUTERINE GROWTH RESTRICTION
    LARRY THAETE; Fiscal Year: 2002
    ..Cellular localization of ET, ET receptors, and NOS isoforms will be performed with immunocytochemistry. ..
  28. Calcium influx pathways in lymphocytes and mast cells
    Jean Pierre Kinet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. Pilot Testing of VEGF/PDGF inhibitors for chemoprevention of bone metastasis
    Hyeong Reh Kim; Fiscal Year: 2007
    ..This information will be useful in designing more rational therapeutic interventions aimed at modulating the PDGF/VEGF signaling pathways. [unreadable] [unreadable] [unreadable]..
  30. INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORS
    JOEL BENNETT; Fiscal Year: 2002
    ..Our results suggest that it may be possible to inhibit the formation of platelet thrombi in arteries involved by atherosclerosis by preventing the interaction of platelet alphavbeta3 with osteopontin. ..
  31. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
    ..Moreover, they will provide the proof of concept for the therapeutic use of these antibodies in the context of MC-associated diseases. ..
  32. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
    ..The focus of the studies presented here is to provide evidence to support the hypothesis that these drugs can act as novel agents to prevent skin cancer formation. ..
  33. Characterizing the Phenotype of Staphylococcal Biofilms
    Julia Ross; Fiscal Year: 2008
    ..Completion of these specific aims will provide a rational basis for the design of new therapeutic molecules. ..
  34. PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Paul Bray; Fiscal Year: 2001
    ..b>Platelet membrane glycoproteins, especially alphaIIb-beta3 are highly polymorphic, and our preliminary studies demonstrate a ..
  35. Intrauterine Inflammation & Adverse Neurological Outcome
    Michal A Elovitz; Fiscal Year: 2010
    ..abstract_text> ..
  36. Regulation of vascular development and function by LKLF
    Mark L Kahn; Fiscal Year: 2010
    ..Understanding the mechanism by which LKLF regulates genetic responses in the developing and mature vasculature is expected to provide new insights into the pathogenesis and treatment of human vascular diseases. ..
  37. Siblings With Ischemic Stroke Study (SWISS)
    JAMES MESCHIA; Fiscal Year: 2009
    ..DNA banking and the creation of permanent lymphoblastoid cell lines will be done to permit future collaborative efforts to study the genetic basis for stroke risk. ..
  38. Spatio-temporal analysis of HIV-1 assembly and release
    Markus Thali; Fiscal Year: 2008
    ..abstract_text> ..
  39. Dissection of cellular interactions with integrated functional genomics in comple
    Martin Hessner; Fiscal Year: 2008
    ..Understanding the relationship between mast cells, T effector, and TREG cells in autoimmunity and has the potential to establish a new paradigm for immune regulation and create new insights to human disease. ..
  40. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved may help with the design of rational approaches to block the induction of immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  41. NIDA DRUG ABUSE RESEARCH COLLABORATION
    GREGORY COLE; Fiscal Year: 2006
    ....
  42. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
    ..Understanding the role of LRP in the migration and invasion astrocytic tumors will provide information on possible specific targets for therapeutic intervention. [unreadable] [unreadable]..
  43. Rare Antigens in Neonatal Alloimmune Thrombocytopenia
    Julie Peterson; Fiscal Year: 2006
    ..4. Generate soluble recombinant platelet glycoproteins carrying "rare" platelet alloantigens to provide a tool for rapid detection and identification of antibodies in mothers who are immunized against these antigens ..
  44. DYNAMIC PLATELET - STAPHYLOCOCCAL INTERACTIONS
    Julia Ross; Fiscal Year: 2004
    ..Completion of these specific aims will provide a rational basis for the design of new therapeutic molecules to block specific adhesion events, as well as identify the most important bacterial receptors to target in vaccine development. ..
  45. GENETIC BASIS OF PLATELET HYPERFUNCTION
    Paul Bray; Fiscal Year: 2004
    ..These studies would greatly enhance our understanding of genetic effects on platelet physiology, and provide a rationale for tailoring anti-thrombotic therapy according to a patient's thrombotic risk phenotype. ..
  46. A molecular signature of cell invasion in breast ca
    Hyeong Reh Kim; Fiscal Year: 2005
    ..The accomplishment of these aims will help us design diagnostic tools to predict primary tumors with metastatic potential. ..
  47. STUDIES OF NATURAL PRODUCTS BY CHIROPTICAL METHODS
    Koji Nakanishi; Fiscal Year: 2004
    ..This will include CD studies of retinal/opsin in rhodopsin and retinal/bacterioopsin in bacteriorhodopsin. Vinca alkaloid/tubulin and taxoid/tubulin complexes will be analyzed by FDCD. ..
  48. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2005
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  49. IMPACT OF ENDOTHELIN IN INTRAUTERINE GROWTH RESTRICTION
    LARRY THAETE; Fiscal Year: 2005
    ....
  50. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
    ..abstract_text> ..
  51. CELLULAR AND MOLECULAR RESPONSES IN LUNG DISEASE
    Guy Zimmerman; Fiscal Year: 2003
    ..abstract_text> ..
  52. LENTIVIRUS-HOST INTERACTIONS DURING ASSEMBLY AND RELEASE
    Markus Thali; Fiscal Year: 2005
    ....
  53. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved in UV-induced immune suppression may help with the design of rational approaches to block immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  54. C-Reactive Protein in Human Mucosal Immunity
    Jane Gould; Fiscal Year: 2005
    ..These results will be tested in vivo using murine models of respiratory tract infection with mice carrying the human CRP transgene. ..
  55. DEFENSIN AND THE PATHOGENESIS OF ATHEROSCLEROSIS
    Douglas Cines; Fiscal Year: 2002
    ..Finally, the interaction between endogenous defensin and endogenous Lp(a) will be examined in a novel transgenic mouse than overexpresses both human defensin and human Lp(a). ..
  56. PDGF Regulation of Cell Growth and Death
    Hyeong Reh Kim; Fiscal Year: 2006
    ....
  57. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
    ..Completion of these specific aims will likely result in targets for in vitro, and possibly clinical, intervention to develop methods to inhibit or to attenuate the effects of these lipids and ultimately make transfusion safer. ..
  58. SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETS
    A Rao; Fiscal Year: 2006
    ..Overall, our studies will provide new important insights into the regulation of two key platelet proteins (G-alpha-q and PLC-beta2) involved in platelet signaling and into the signaling mechanisms in platelets. ..
  59. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
  60. AML1 in Hematopoietic Cell Development
    ROBERT LORSBACH; Fiscal Year: 2006
    ..abstract_text> ..
  61. Cell Biology of Ion Pumps: Sorting and Function
    Michael Caplan; Fiscal Year: 2004
    ..These studies will allow us to determine whether and how specific molecular signals and associations might be related to such clinically significant pathologies as gastric ulcer disease and hypertension. ..