platelet membrane glycoproteins

Summary

Summary: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.

Top Publications

  1. pmc A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, D 80636 München, Germany
    J Exp Med 197:41-9. 2003
  2. pmc In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53
    Magdalena Deneka
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 177:329-41. 2007
  3. pmc A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
    M Moroi
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    J Clin Invest 84:1440-5. 1989
  4. pmc Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    J Exp Med 193:459-69. 2001
  5. doi Trafficking and function of the tetraspanin CD63
    Maaike S Pols
    Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Exp Cell Res 315:1584-92. 2009
  6. ncbi Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets
    Peter A Smethurst
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 282:1296-304. 2007
  7. pmc NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
    M Scatena
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Cell Biol 141:1083-93. 1998
  8. ncbi Increased microvascular permeability in the hamster cheek pouch induced by oxidized low density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins
    E Svensjo
    Laboratório de Imunologia Molecular, Instituto Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro
    Inflamm Res 52:215-20. 2003
  9. ncbi Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation
    M Torti
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 274:13690-7. 1999
  10. ncbi Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
    B A Mannion
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:2039-47. 1996

Research Grants

  1. ROLE OF EICOSANOIDS IN TUMOR CELL METASTASIS
    KENNETH HONN; Fiscal Year: 1993
  2. TUMOR CELL ADHESIVE GLYCOPROTEINS AND METASTASIS
    KENNETH HONN; Fiscal Year: 1990
  3. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
  4. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2007
  5. Carbohydrate-mediated platelet clearance
    KARIN MARIA HOFFMEISTER; Fiscal Year: 2010
  6. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
  7. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
  8. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
  9. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
  10. PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Paul Bray; Fiscal Year: 2001

Detail Information

Publications257 found, 100 shown here

  1. pmc A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, D 80636 München, Germany
    J Exp Med 197:41-9. 2003
    ....
  2. pmc In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53
    Magdalena Deneka
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 177:329-41. 2007
    ..These results indicate that, in macrophages, HIV-1 exploits a previously undescribed intracellular plasma membrane domain to assemble infectious particles...
  3. pmc A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
    M Moroi
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    J Clin Invest 84:1440-5. 1989
    ..The patient's platelets did not bind to types I and III collagen fibrils. Our results suggest that GPVI functions as a collagen receptor...
  4. pmc Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    J Exp Med 193:459-69. 2001
    ....
  5. doi Trafficking and function of the tetraspanin CD63
    Maaike S Pols
    Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Exp Cell Res 315:1584-92. 2009
    ..In this review we discuss the latest insights in CD63 trafficking and its emerging function as a transport regulator of its interaction partners. Finally, the involvement of CD63 in cancer will be discussed...
  6. ncbi Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets
    Peter A Smethurst
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 282:1296-304. 2007
    ..Furthermore, we propose that the (GPO)4 motif can support simultaneous binding of two glycoprotein VI molecules, in either a parallel or anti-parallel stacking arrangement, which could play an important role in activation of signaling...
  7. pmc NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
    M Scatena
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Cell Biol 141:1083-93. 1998
    ..In contrast, inhibition of MEK and PI3-kinase did not affect osteopontin-induced NF-kappaB activation. These studies identify NF-kappaB as an important signaling molecule in alphavbeta3 integrin-mediated endothelial cell survival...
  8. ncbi Increased microvascular permeability in the hamster cheek pouch induced by oxidized low density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins
    E Svensjo
    Laboratório de Imunologia Molecular, Instituto Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro
    Inflamm Res 52:215-20. 2003
    ..Oxidized low-density lipoproteins (oxLDL) and protein fractions obtained by size exclusion chromatography of oxLDL were tested for vascular permeability effects on topical application to the hamster cheek pouch...
  9. ncbi Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation
    M Torti
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 274:13690-7. 1999
    ..Our results indicate that translocation of Rap1B and Rap2B to the cytoskeleton is regulated by tyrosine kinases and suggest a novel role for the FcgammaII receptor in the mechanism of platelet activation by vWF...
  10. ncbi Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
    B A Mannion
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:2039-47. 1996
    ..Thus, CD81 and other transmembrane-4 superfamily members may participate in functionally relevant interactions with alpha 4 beta 1 and other integrins...
  11. doi Platelet receptor signaling in thrombus formation
    David Stegner
    Chair of Vascular Medicine, University Hospital and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    J Mol Med (Berl) 89:109-21. 2011
    ..This review summarizes the most important receptor systems and signaling mechanisms involved in platelet activation and thrombus formation with special focus on recent discoveries...
  12. doi Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
    Mohammad Al-Tamimi
    Monash University, Melbourne VI, Australia
    Stroke 42:498-500. 2011
    ..Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding...
  13. doi Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding
    Mohammad Al-Tamimi
    Department of Immunology, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Platelets 20:75-82. 2009
    ..In conclusion, this analysis of anti-GPVI mAbs provides useful tools for studying the functional role of platelet GPVI...
  14. ncbi Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    B Savage
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, La Jolla, California 92037, USA
    Cell 84:289-97. 1996
    ..This eventually allows activated alpha IIb beta 3 to arrest platelets onto vWF under conditions not permissive of direct binding to fibrinogen. The coupling of these different functions may be crucial for thrombogenesis...
  15. pmc Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain
    Shigeo Hasegawa
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 5:e10467. 2010
    ..However, lipid mediators downstream of cPLA(2) activation to produce tactile allodynia remain to be determined...
  16. doi Pivotal role for platelet-activating factor receptor in CD36 expression and oxLDL uptake by human monocytes/macrophages
    Francisco J O Rios
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Cell Physiol Biochem 27:363-72. 2011
    ..These results suggest that oxLDL interacts with PAFR in macrophages to increase CD36 expression and oxLDL uptake. Whereas pharmacological intervention at the level of PAFR would be beneficial in atherosclerosis remains to be determined...
  17. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
    ..Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases...
  18. pmc Identification of a major GpVI-binding locus in human type III collagen
    Gavin E Jarvis
    Departments of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 111:4986-96. 2008
    ..These data indicate that the ability of a triple-helical peptide to bind GpVI is not solely determined by the presence or spatial arrangement of these OGP/GPO motifs within the peptides...
  19. ncbi Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
    H K Nieuwenhuis
    Nature 318:470-2. 1985
    ..We now report a defect of the platelet plasma membrane glycoprotein composition in a patient whose platelets are totally unresponsive to collagen...
  20. ncbi Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpain
    P Siljander
    Wihuri Research Institute, and the Electron Microscopy Unit, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 21:618-27. 2001
    ..We conclude that the procoagulant response evoked by GPVI stimulation is potentiated by platelet adhesion. The sequential activation of p38 MAPK and calpain appears to regulate procoagulant membrane blebbing but not PS exposure...
  21. ncbi Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo
    Steffen Massberg
    Klinikum rechts der Isar, 1 Medizinische Klinik, Technische Universitat Munchen, D 81675 Munchen, Germany
    FASEB J 18:397-9. 2004
    ..These findings further substantiate the critical role of the collagen receptor GPVI in the initiation of thrombus formation at sites of vascular injury and identify soluble GPVI as a promising antithrombotic strategy...
  22. ncbi The growing complexity of platelet aggregation
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Blood 109:5087-95. 2007
    ....
  23. ncbi A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase
    F Berditchevski
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:2595-8. 1997
    ....
  24. ncbi Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
    ..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
  25. ncbi Platelet-activating factor receptor
    Zen Ichiro Honda
    Department of Allergy, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biochem 131:773-9. 2002
    ..Establishment of PAFR(-/-) mice confirmed that the PAF receptor is responsible for pro-inflammatory responses, but that its roles in other settings remain to be clarified...
  26. pmc von Willebrand factor binding to platelet GpIb initiates signals for platelet activation
    M H Kroll
    Houston Veterans Affairs Medical Center, Baylor College of Medicine, Texas 77030
    J Clin Invest 88:1568-73. 1991
    ..This signal then causes PKC activation and increases of [Ca2+]i, which promote platelet secretion and potentiate aggregation...
  27. ncbi Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor
    J Polgar
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    J Biol Chem 272:13576-83. 1997
    ....
  28. ncbi Evidence that HIV budding in primary macrophages occurs through the exosome release pathway
    Deborah Greene Nguyen
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:52347-54. 2003
    ..These results strongly support the Trojan exosome hypothesis and its prediction that retroviral budding represents exploitation of a pre-existing cellular pathway of intercellular vesicle trafficking...
  29. ncbi CD82, and CD63 in thyroid cancer
    Zhouxun Chen
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
    Int J Mol Med 14:517-27. 2004
    ..CD82 may serve as a prognostic marker of metastasis in thyroid cancer. Constitutive expression of CD63 may indicate that this factor does not play a direct role in thyroid carcinogenesis...
  30. pmc Glycoprotein VI oligomerization in cell lines and platelets
    O Berlanga
    Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    J Thromb Haemost 5:1026-33. 2007
    ..Constitutive dimerization of GPVI has been proposed as being necessary for the interaction with collagen, although direct evidence of dimerization has not been reported in cell lines or platelets...
  31. pmc Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor
    T E O'Toole
    Research Institute of Scripps Clinic, La Jolla, California 92037
    Cell Regul 1:883-93. 1990
    ..Furthermore, they indicate that the activation state of alpha IIb beta 3 is a property of the receptor itself rather than of the surrounding cell membrane microenvironment...
  32. ncbi Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
    T J Kovacsovics
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Biol Chem 270:11358-66. 1995
    ..PI 3-K stimulation downstream of GPIIb-IIIa engagement may provide positive feedback required to sustain active GPIIb-IIIa...
  33. doi A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder
    C Hermans
    Department of Haematology, Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Brussels, Belgium
    J Thromb Haemost 7:1356-63. 2009
    ..Remarkably, patients with a proven GPVI gene mutation have not yet been identified...
  34. doi Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka Ken, Japan
    J Thromb Haemost 7:1347-55. 2009
    ..The platelet collagen receptor glycoprotein (GP) VI is suggested to exist as a dimer on the platelet surface, but no direct proof of the functional importance of dimer formation has been provided...
  35. ncbi Tetraspanin CD63 promotes targeting and lysosomal proteolysis of membrane-type 1 matrix metalloproteinase
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, 920 0934, Kanazawa, Japan
    Biochem Biophys Res Commun 304:160-6. 2003
    ..CD63 mutant lacking lysosomal targeting motif was unable to promote MT1-MMP degradation. These results suggest that CD63 regulates MT1-MMP by targeting to lysosomes...
  36. ncbi Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane
    Jane F Arthur
    Department of Immunology, Monash University, Melbourne 3004, Australia
    J Biol Chem 282:30434-41. 2007
    ....
  37. ncbi A cell surface glycoprotein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491
    S Kitani
    Clinical Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 266:1903-9. 1991
    ..Therefore, mAb AD1 binds to a surface glycoprotein on RBL-2H3 cells sterically close to the Fc epsilon RI but distinct from the recognized subunits of the receptor...
  38. ncbi Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen
    M N O'Connor
    Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK
    J Thromb Haemost 4:869-73. 2006
    ..Recently, others have postulated the involvement of a portion of the first domain distant from the interdomain hinge as being involved in an extended collagen-binding site...
  39. doi Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity
    Stéphane Loyau
    INSERM U698, CHU Xavier Bichat, 46 rue Henri Huchard 75877 Paris Cedex 18, France
    Arterioscler Thromb Vasc Biol 32:778-85. 2012
    ..The valence of GPVI on resting platelets needs to be clearly established because platelet avidity for collagen would be greater if GPVI is constitutively expressed as a dimer than as a monomer...
  40. pmc Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e3793. 2008
    ..Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation...
  41. ncbi Selective blockade of glycoprotein VI clustering on collagen helices
    Marie N O'Connor
    Department of Haematology, University of Cambridge, Cambridge CB2 2PT, UK
    J Biol Chem 281:33505-10. 2006
    ..Together these results indicate that 1C3 inhibits clustering of the immunoglobulin-like domains of GPVI on collagen/CRPs, a conclusion that is supported by mapping the 1C3 epitope to the region including isoleucine 148 in D2...
  42. ncbi Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition
    K Horstrup
    Medizinische Universitatsklinik, Klinische Forschergruppe, Wurzburg, Germany
    Eur J Biochem 225:21-7. 1994
    ..It is proposed that the inhibition of glycoprotein IIb-IIIa induced by cyclic nucleotide involves cAMP-and cGMP-dependent protein-kinase-mediated VASP phosphorylation at Ser157...
  43. ncbi Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation
    O Berlanga
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 96:2740-5. 2000
    ..The results demonstrate that expression of GPVI is up-regulated along with the FcR gamma-chain during differentiation of megakaryocytes. (Blood. 2000;96:2740-2745)..
  44. doi Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion
    Stephanie M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan
    Platelets 19:32-42. 2008
    ..Our present results suggest that the physiological importance of type III collagen is to induce thrombus formation. Furthermore, these studies indicate that GPVI mainly binds to collagen types that can form large collagen fibrils...
  45. ncbi The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines
    Tao Li
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:16614-21. 2003
    ..These studies provide evidence for a novel pathway whereby the epidermal PAF-R can augment chemotherapy-induced apoptotic effects through an NF-kappaB-dependent process...
  46. doi Expression of platelet-activating factor receptor: a novel prognosticator in patients with hepatocellular carcinoma following hepatectomy
    Dai Kitagawa
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncology 72:381-7. 2007
    ..Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the development of hepatocellular carcinoma (HCC) remains to be elucidated...
  47. ncbi Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets
    S P Jackson
    Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    J Biol Chem 269:27093-9. 1994
    ..Our results suggest that vWF binding to the platelet adhesion receptor glycoprotein Ib/IX can mediate activation and translocation of both tyrosine and lipid kinase(s) independent of other agonists...
  48. doi Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1
    Giordano Pula
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol, UK
    Platelets 19:199-210. 2008
    ....
  49. ncbi CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma
    K J Radford
    Oncology and Immunology Unit, David Maddison Clinical Sciences Building, Newcastle, New South Wales, Australia
    Biochem Biophys Res Commun 222:13-8. 1996
    ..The results suggest that CD63 is capable of forming multicomponent complexes with TM4SF members and beta 1 integrins on the surface of melanoma. These findings provide further insights into the function of CD63...
  50. ncbi Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor
    A Marilise Marrache
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Immunol 169:6474-81. 2002
    ..This study describes for the first time the nucleus as a putative organelle capable of generating PAF and expresses its receptor, which upon stimulation induces the expression of the proinflammatory gene COX-2...
  51. pmc Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy
    Hisako Hikiji
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Japan
    J Clin Invest 114:85-93. 2004
    ..Inhibition of PAF function might pave the way for a new strategy to prevent postmenopausal bone loss without disturbing osteoblast functions...
  52. ncbi Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy
    Martin Hervé Beauchamp
    Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 43:3327-37. 2002
    ..To test whether platelet-activating factor (PAF) directly causes retinovascular endothelial cell (EC) death...
  53. ncbi Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications
    J A Lopez
    Gladstone Institute of Cardiovascular Disease, San Francisco, California
    J Biol Chem 267:10055-61. 1992
    ..Such a change may alter the susceptibility of platelets to shear-induced activation, a process that requires an interaction between glycoprotein Ib and von Willebrand factor...
  54. ncbi GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism
    Simon Lockyer
    Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Thromb Res 118:371-80. 2006
    ..These observations clearly establish that blockade of GPVI may attenuate platelet-collagen interactions without adversely affecting the bleeding time...
  55. ncbi Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets
    Jane F Arthur
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Haemost 93:716-23. 2005
    ..A contribution of GPIb-IX-V to GPVI-induced platelet responses, and vice versa, therefore warrants further investigation...
  56. pmc Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets
    Soochong Kim
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:33763-72. 2009
    ..In addition, a significant portion of GPVI-dependent, ADP-independent Akt activation also exists, and PI3Kbeta plays an essential role in GPVI-mediated platelet aggregation and Akt activation...
  57. ncbi PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
    P J Newman
    The Blood Center of Southeastern Wisconsin, Milwaukee 53233
    Science 247:1219-22. 1990
    ..This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events...
  58. ncbi CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells
    M J Metzelaar
    Department of Haematology, University Hospital Utrecht, The Netherlands
    J Biol Chem 266:3239-45. 1991
    ..CD63 was not related to the lysosomal glycoprotein family but contained the putative lysosomal targeting signal Gly-Tyr in its short cytoplasmic tail...
  59. ncbi Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
    S Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Prog Lipid Res 39:41-82. 2000
    ..This review also describes the phenotypes of these mutant mice and discusses them by referring to previously reported pharmacological and genetical data...
  60. ncbi Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Circulation 115:2323-30. 2007
    ..In the present study, we addressed the pathogenic role of GPIb, GPVI, and the aggregation receptor GPIIb/IIIa in experimental stroke in mice...
  61. ncbi GPVI and integrin alphaIIb beta3 signaling in platelets
    S P Watson
    Division of Medical Sciences, Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 3:1752-62. 2005
    ..The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed...
  62. ncbi Signaling events underlying thrombus formation
    S P Jackson
    Australian Center for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    J Thromb Haemost 1:1602-12. 2003
    ..The role of soluble agonists in promoting thrombus growth will be highlighted and a model to explain the synergistic requirement for adhesive and soluble stimuli for efficient platelet aggregation will be discussed...
  63. pmc HIV-1 buds predominantly at the plasma membrane of primary human macrophages
    Sonja Welsch
    Department of Virology, University of Heidelberg, Heidelberg, Germany
    PLoS Pathog 3:e36. 2007
    ..Thus, contrary to current opinion, the plasma membrane is the primary site of HIV-1 budding also in infected macrophages...
  64. ncbi Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins
    Iain C Macaulay
    Department of Haematology, University of Cambridge, Cambridge, UK
    Blood 109:3260-9. 2007
    ..The identification of the succinate receptor SUCNR1 in platelets is of particular interest, because physiologically relevant concentrations of succinate were shown to potentiate the effect of low doses of a variety of platelet agonists...
  65. pmc Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains
    Clare Jolly
    The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
    J Virol 81:7873-84. 2007
    ..We propose that HIV-1 promotes virus assembly and cell-cell transfer in T cells by targeting plasma membrane TEMs...
  66. pmc Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor
    Yasuyuki Kihara
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Exp Med 202:853-63. 2005
    ..PAFR-KO macrophages reduced phagocytic activity and subsequent production of TNF-alpha. These results suggest that PAF plays a dual role in EAE pathology in the induction and chronic phases through the T cell-independent pathways...
  67. pmc Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection
    Danielle G Souza
    Immunopharmacology, Departmento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Proc Natl Acad Sci U S A 106:14138-43. 2009
    ..PAFR antagonists are disease-modifying agents in experimental dengue infection...
  68. ncbi A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
    Ton Lisman
    Department of Biochemistry, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 108:3753-6. 2006
    ..23 either strongly interacted with both VWF and platelets or lacked both VWF and platelet binding. Thus, we identified the sequence RGQOGVMGF (O is hydroxyproline) as the minimal VWF-binding sequence in collagen III...
  69. ncbi Involvement of platelet-activating factor and LIS1 in neuronal migration
    Suzumi M Tokuoka
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, CREST of JST, Tokyo 113 0033, Japan
    Eur J Neurosci 18:563-70. 2003
    ....
  70. ncbi Genetic variants of platelet glycoprotein receptors and risk of stroke in young women
    A P Reiner
    Departments of Medicine, University of Washington, Seattle, WA 98195 9756, USA
    Stroke 31:1628-33. 2000
    ..Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined...
  71. pmc PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways
    Chris I Jones
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, Berkshire RG6 6UB, UK
    FEBS Lett 583:3618-24. 2009
    ..This combined inhibition of multiple signaling pathways results in a marked reduction in thrombus formation...
  72. ncbi Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo
    Marijke J E Kuijpers
    Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
    FASEB J 17:685-7. 2003
    ....
  73. ncbi Platelet-collagen interaction: is GPVI the central receptor?
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine Versbacher, Wurzburg, Germany
    Blood 102:449-61. 2003
    ..This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis...
  74. ncbi c-Cbl negatively regulates platelet activation by glycoprotein VI
    J M Auger
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    J Thromb Haemost 1:2419-26. 2003
    ..c-Cbl is tyrosine-phosphorylated in response to stimulation of GpVI, whereas phosphorylation of c-Cbl in thrombin-activated platelets is dependent on fibrinogen binding to the integrin GpIIb/IIIa...
  75. ncbi Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody
    Peter A Smethurst
    Department of Haematology, University of Cambridge and National Blood Service Cambridge, Long Road, Cambridge, CB2 2PT, United Kingdom
    Blood 103:903-11. 2004
    ..Antibody 10B12 showed significantly reduced binding to the hD1D2-E59, and, on that basis, the GPVI:10B12 interface was modeled...
  76. ncbi Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen
    Yoshiki Miura
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432 3 Aikawa machi, Kurume, Fukuoka 839 0861, Japan
    J Biol Chem 277:46197-204. 2002
    ..Moreover, surface plasmon resonance indicated that there is no detectable interaction between soluble collagen and GPVI, supporting our previous observation that GPVI only reacts with fibrous collagen...
  77. ncbi Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis
    Olga Zinchuk
    Department of Ophthalmology, Laboratory of Immunology, Kochi Medical School, Nankoku, Kochi, Japan
    Mol Vis 11:114-23. 2005
    ..Colocalization analysis has been employed to quantify the degree of colocalization of major basic protein (MBP) and PAF-R antigens in the course of PAF induced conjunctivitis...
  78. pmc The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit
    Amy Duffield
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:15560-5. 2003
    ..These data indicate that CD63 serves as an adaptor protein that links its interaction partners to the endocytic machinery of the cell and suggest a previously uncharacterized protein-trafficking role for the tetraspanins...
  79. ncbi Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 290:L194-9. 2006
    ..These data indicate that the pneumococcus uses the PAFR leading to severe pneumonia in a host previously exposed to influenza A...
  80. pmc Impaired activation of platelets lacking protein kinase C-theta isoform
    Bela Nagy
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 113:2557-67. 2009
    ..In conclusion, PKC-theta isoform plays a significant role in platelet functional responses downstream of PAR and GPVI receptors...
  81. doi Cell adhesion mechanisms in platelets
    David Varga-Szabo
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Zinklesweg 10, 97078 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 28:403-12. 2008
    ..This review summarizes the most important structural and functional properties of these adhesion receptors and briefly discusses their potential as targets for antithrombotic therapy...
  82. pmc The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Scand J Infect Dis 40:11-7. 2008
    ....
  83. pmc Minimal regulation of platelet activity by PECAM-1
    Tarvinder S Dhanjal
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Platelets 18:56-67. 2007
    ....
  84. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  85. pmc GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk
    Sascha C Hughan
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK
    Arterioscler Thromb Vasc Biol 27:422-9. 2007
    ..The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet adhesion receptors...
  86. pmc Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification
    Katerina Artavanis-Tsakonas
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:15945-50. 2006
    ..These observations indicate that the composition of distinct phagosomal compartments within the same cell is determined by phagosomal cargo and may affect the outcome of antigen processing and presentation...
  87. ncbi Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Dermatol 15:769-74. 2006
    ..These studies suggest that SZ95 sebocytes express functional PAF-Rs and PAF-Rs are involved in regulating the expression of inflammatory mediators, including COX-2, PGE(2) and IL-8...
  88. ncbi Platelet activating factor receptor-deficient mice present delayed interferon-gamma upregulation and high susceptibility to Leishmania amazonensis infection
    Helton C Santiago
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, CP 486, Av Antonio Carlos 6627, Pampulha, CEP 30161 970 Belo Horizonte, MG, Brazil
    Microbes Infect 8:2569-77. 2006
    ..amazonensis by PAFR(-/-) mice. We conclude that signaling through the PAFR is essential for the ability of the murine host to control L. amazonensis infection by driving an adequate immune response...
  89. ncbi Phagocytosis of apoptotic and necrotic thymocytes is inhibited by PAF-receptor antagonists and affects LPS-induced COX-2 expression in murine macrophages
    Soraya Imon de Oliveira
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1730, 05508 900 Sao Paulo, Brazil
    Prostaglandins Other Lipid Mediat 80:62-73. 2006
    ..These findings indicate that apoptotic and necrotic cells share common ligands with PAF and oxLDL and suggest the involvement of PAF-like receptors in the enhanced clearance of these cells...
  90. pmc Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
    Amy M Booth
    Department of Biological Chemistry and 2Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 172:923-35. 2006
    ..In support of this, we find that Jurkat T cells direct the key budding factor of HIV, HIV Gag, to these endosome-like domains of plasma membrane and secrete HIV Gag from the cell in exosomes...
  91. pmc Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo
    Christophe Dubois
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, 840 Memorial Drive, Cambridge, MA 02139, USA
    Blood 107:3902-6. 2006
    ..It may thus be important when considering targets for antithrombotic therapy to use multiple animal models with diverse pathways to thrombus formation...
  92. ncbi Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency
    Pierre Mangin
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia
    Blood 107:4346-53. 2006
    ..Moreover, they raise the interesting possibility that the full antithrombotic potential of GPVI receptor antagonists may only be realized through the concurrent administration of anticoagulant agents...
  93. ncbi Phospholipid mediators in the vessel wall: involvement in atherosclerosis
    Ewa Ninio
    INSERM U525, IFR14 Coeur Muscle Vaisseaux and Université P M Curie, Faculte de Medecine, Paris, France
    Curr Opin Clin Nutr Metab Care 8:123-31. 2005
    ....
  94. ncbi Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites
    Christelle Lecut
    INSERM, E348, Faculte de Medecine Xavier Bichat, Paris Cedex 18, France
    J Biol Chem 279:52293-9. 2004
    ..Site-directed mutagenesis revealed that valine 34 and leucine 36 are critical for GPVI interaction with collagen and CRP. The loop might thus be part of a collagen/CRP-binding site...
  95. ncbi Beneficial effects of recombinant platelet-activating factor acetylhydrolase and BN 52021 on bacterial translocation in cerulein-induced pancreatitis
    A Bedirli
    Department of Surgery, Gazi University, Faculty of Medicine, Ankara, Turkey
    Eur Surg Res 36:136-41. 2004
    ..The aim of this study was to investigate the effects of the platelet-activating factor (PAF) inactivator, recombinant PAF-acetylhydrolase (rPAF-AH), and the PAF receptor antagonist, BN 52021, in AP...
  96. ncbi Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw
    Denise M Marotta
    Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Biochem Pharmacol 77:1223-35. 2009
    ..They also support the concept that selective PAF receptor antagonists might constitute interesting targets for the development of new analgesic drugs...
  97. ncbi Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane
    X Du
    Blood 69:1524-7. 1987
    ..The combined data suggests that GP lb and GP IX are fully complexed in the intact platelet membrane...
  98. ncbi Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA
    H Bito
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 221:211-8. 1994
    ..Isolation of rat PAF-receptor cDNA should facilitate further analysis of PAF-receptor function and pharmacology in diverse pathophysiological processes...
  99. pmc Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    EMBO J 20:2120-30. 2001
    ..These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential...
  100. ncbi Expression and function of the collagen receptor GPVI during megakaryocyte maturation
    A H Lagrue-Lak-Hal
    INSERM E9907, , 75870 Paris Cedex 18, Paris, France
    J Biol Chem 276:15316-25. 2001
    ..Our results showed that GPVI is expressed early during megakaryocytic differentiation but functionally allows megakaryocyte adherence to collagen only at late stages of differentiation when its expression increases...
  101. ncbi The protein tyrosine kinase Hck is located on lysosomal vesicles that are physically and functionally distinct from CD63-positive lysosomes in human macrophages
    Catherine Astarie-Dequeker
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique UMR 5089, 205 route de Narbonne, 31077 Toulouse, France
    J Cell Sci 115:81-9. 2002
    ..Therefore, Hck represents a new tool to study the fusion dynamics of lysosomal compartments and their subversion by several intracellular pathogens...

Research Grants69

  1. ROLE OF EICOSANOIDS IN TUMOR CELL METASTASIS
    KENNETH HONN; Fiscal Year: 1993
    ..Finally, we will attempt to correlate tumor cell lipoxygenase activity and integrin receptor expression with metastatic potential in vivo...
  2. TUMOR CELL ADHESIVE GLYCOPROTEINS AND METASTASIS
    KENNETH HONN; Fiscal Year: 1990
    ..This proposal will therefore seek to establish functional significance for these glycoproteins in biological processes (i.e., adhesion, etc.) relevant to tumor metastasis...
  3. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  4. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2007
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  5. Carbohydrate-mediated platelet clearance
    KARIN MARIA HOFFMEISTER; Fiscal Year: 2010
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  6. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  7. Carbohydrate-mediated platelet clearance
    Karin Hoffmeister; Fiscal Year: 2009
    ..We will further determine if platelet resialylation prevents the ingestion of desialylated platelets in vitro (Aim 2C). ..
  8. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  9. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  10. PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Paul Bray; Fiscal Year: 2001
    ..b>Platelet membrane glycoproteins, especially alphaIIb-beta3 are highly polymorphic, and our preliminary studies demonstrate a ..
  11. Rare Antigens in Neonatal Alloimmune Thrombocytopenia
    Julie Peterson; Fiscal Year: 2006
    ..4. Generate soluble recombinant platelet glycoproteins carrying "rare" platelet alloantigens to provide a tool for rapid detection and identification of antibodies in mothers who are immunized against these antigens ..