bone cements

Summary

Summary: Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.

Top Publications

  1. ncbi Percutaneous vertebroplasty
    David F Kallmes
    Department of Radiology, University of Virginia Health Sciences Center, PO Box 800170, Charlottesville, VA 22908, USA
    Radiology 229:27-36. 2003
  2. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
  3. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
  4. pmc Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures
    Wender Figved
    Orthopaedic Centre, Ulleval University Hospital, Oslo, Norway
    Clin Orthop Relat Res 467:2426-35. 2009
  5. ncbi New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures
    S R Garfin
    University of California, San Diego, California, USA
    Spine (Phila Pa 1976) 26:1511-5. 2001
  6. ncbi Percutaneous vertebroplasty for spinal metastases: complications
    Héctor Manuel Barragán-Campos
    Department of Diagnostic and Interventional Neuroradiology, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie Paris VI, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Radiology 238:354-62. 2006
  7. ncbi Percutaneous transpedicular vertebroplasty with calcium phosphate cement in the treatment of osteoporotic vertebral compression and burst fractures
    Masato Nakano
    Department of Orthopaedic Surgery, Toyama Rosai Hospital, Japan
    J Neurosurg 97:287-93. 2002
  8. ncbi Hemiarthroplasty of the hip with and without cement: a randomized clinical trial
    Fraser Taylor
    Auckland City Hospital, Private Bag 92 024, Auckland Mail Centre, Auckland 1142, New Zealand
    J Bone Joint Surg Am 94:577-83. 2012
  9. ncbi Development of a strontium-containing hydroxyapatite bone cement
    Dagang Guo
    State Key Laboratory for Mechanical Behavior of Materials, Xi an Jiaotong University, Xianning Western Road No 28, Xi an, Shaan X 710049, China
    Biomaterials 26:4073-83. 2005
  10. ncbi Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial
    Douglas Wardlaw
    Orthopaedic Department, Woodend Hospital, NHS Grampian, Aberdeen, UK
    Lancet 373:1016-24. 2009

Research Grants

  1. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
  2. A Novel Biomimetic Bone Cement For Immediately Loaded Dental Implants
    DAVID ALLEN GAUL; Fiscal Year: 2010
  3. DEVELOPMENT OF PICKERING EMULSIONS AS INJECTABLE BONE GRAFTS
    ELIZABETH MARIE COSGRIFF-HERNANDEZ; Fiscal Year: 2013
  4. Polyurethane Bone Cements for Total Hip Implants
    Ibrahim Sendijarevic; Fiscal Year: 2010
  5. Bone cements for delivery of osteoinductive growth factors
    Jonathan A Hodges; Fiscal Year: 2011
  6. Calcium Phosphate Bone Cement Nanocomposites
    KENNETH LAWRENCE LAMBERT; Fiscal Year: 2010
  7. INJECTABLE RESORBABLE BONE CEMENT
    JOSEPH GRESSER; Fiscal Year: 1999
  8. A NOVEL METAL-POLYMER COMPOSITE FOR AMALGAM REPLACEMENT
    Ivan Stangel; Fiscal Year: 2001
  9. BIODEGRADABLE POLYACTIDE-CO-GLYCOLIDE MEDICAL CEMENTS
    Larry Nichols; Fiscal Year: 2000
  10. BIOACTIVE CALCIUM PHOSPHATE GLASSES FOR HYPERTHERMIA
    YONGREN PENG; Fiscal Year: 1993

Detail Information

Publications309 found, 100 shown here

  1. ncbi Percutaneous vertebroplasty
    David F Kallmes
    Department of Radiology, University of Virginia Health Sciences Center, PO Box 800170, Charlottesville, VA 22908, USA
    Radiology 229:27-36. 2003
    ..Finally, the current state of evidence in support of the efficacy of vertebroplasty are discussed, with particular attention to the need for ongoing clinical trials...
  2. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
    ..We present here an overview of bone grafts and graft substitutes available for clinical applications...
  3. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
    ..Since the practice of using undocumented implants has not changed, the register will continue to survey these implants. We plan to assess the mid- and long-term results of implants that have so far had good short-term results...
  4. pmc Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures
    Wender Figved
    Orthopaedic Centre, Ulleval University Hospital, Oslo, Norway
    Clin Orthop Relat Res 467:2426-35. 2009
    ..The rates of complications and mortality were similar between groups. Both arthroplasties may be used with good results after displaced femoral neck fractures...
  5. ncbi New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures
    S R Garfin
    University of California, San Diego, California, USA
    Spine (Phila Pa 1976) 26:1511-5. 2001
    ..Literature review...
  6. ncbi Percutaneous vertebroplasty for spinal metastases: complications
    Héctor Manuel Barragán-Campos
    Department of Diagnostic and Interventional Neuroradiology, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie Paris VI, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Radiology 238:354-62. 2006
    ..To retrospectively evaluate complications of percutaneous vertebroplasty (PV) performed with polymethylmethacrylate cement to treat pain in patients with metastases to the spine...
  7. ncbi Percutaneous transpedicular vertebroplasty with calcium phosphate cement in the treatment of osteoporotic vertebral compression and burst fractures
    Masato Nakano
    Department of Orthopaedic Surgery, Toyama Rosai Hospital, Japan
    J Neurosurg 97:287-93. 2002
    ..The authors describe a series of patients in whom they performed percutaneous vertebroplasty by using calcium phosphate cement (CPC) to obtain early pain relief and improve the integrity of the osteoporotic vertebral body (VB)...
  8. ncbi Hemiarthroplasty of the hip with and without cement: a randomized clinical trial
    Fraser Taylor
    Auckland City Hospital, Private Bag 92 024, Auckland Mail Centre, Auckland 1142, New Zealand
    J Bone Joint Surg Am 94:577-83. 2012
    ..The primary hypothesis of this study was that use of cement would provide better visual analog pain scores following this procedure in an elderly patient population...
  9. ncbi Development of a strontium-containing hydroxyapatite bone cement
    Dagang Guo
    State Key Laboratory for Mechanical Behavior of Materials, Xi an Jiaotong University, Xianning Western Road No 28, Xi an, Shaan X 710049, China
    Biomaterials 26:4073-83. 2005
    ....
  10. ncbi Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial
    Douglas Wardlaw
    Orthopaedic Department, Woodend Hospital, NHS Grampian, Aberdeen, UK
    Lancet 373:1016-24. 2009
    ..Balloon kyphoplasty is a minimally invasive procedure for the treatment of painful vertebral fractures, which is intended to reduce pain and improve quality of life. We assessed the efficacy and safety of the procedure...
  11. pmc Giant cell tumor of bone: risk factors for recurrence
    Frank M Klenke
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Orthop Relat Res 469:591-9. 2011
    ..However, the best treatment of these tumors and risk factors for recurrence remain controversial...
  12. ncbi Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial
    Caroline A H Klazen
    Radiology, St Elisabeth Ziekenhuis, Tilburg, Netherlands
    Lancet 376:1085-92. 2010
    ..We aimed to clarify whether vertebroplasty has additional value compared with optimum pain treatment in patients with acute vertebral fractures...
  13. ncbi An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty
    Frank M Phillips
    University of Chicago Spine Center, Chicago, Illinois 60640, USA
    Spine (Phila Pa 1976) 27:2173-8; discussion 2178-9. 2002
    ..A prospective in vivo study was conducted during the performance of kyphoplasty for the treatment of osteoporotic vertebral compression fractures, comparing extravertebral contrast extravasation with kyphoplasty and vertebroplasty...
  14. ncbi Bioactive bone cement as a principal fixture for spinal burst fracture: an in vitro biomechanical and morphologic study
    W W Lu
    Department of Orthopaedic Surgery, University of Hong Kong, China
    Spine (Phila Pa 1976) 26:2684-90; discussion 2690-1. 2001
    ..An in vitro biomechanical and radiographic study to evaluate the properties of a newly developed bioactive bone cement for stabilization of the fractured spine, suitable for minimally invasive application...
  15. pmc A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases
    Ira J Miller
    Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison 300 Chicago, IL, 60612, USA
    Diagn Pathol 5:62. 2010
    ..Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT...
  16. pmc Durable infection control and function with the PROSTALAC spacer in two-stage revision for infected knee arthroplasty
    Christopher R Gooding
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada
    Clin Orthop Relat Res 469:985-93. 2011
    ..The PROSTALAC knee spacer is an antibiotic-loaded cement articulating spacer that allows some movement of the knee between stages. Whether motion enhances long-term function is unknown...
  17. ncbi Adjacent vertebral fractures after percutaneous vertebral augmentation of osteoporotic vertebral compression fracture: a comparison of balloon kyphoplasty and vertebroplasty
    I Movrin
    Department of Traumatology, University Medical Centre Maribor, Ljubljanska 5, Maribor, Slovenia
    Arch Orthop Trauma Surg 130:1157-66. 2010
    ..The purpose of this study was to evaluate the adjacent level fracture risk after BK as compared with VP and to determine the possible dominant risk factor associated with new compression fractures...
  18. ncbi An intraoperatively moulded PMMA prostheses like spacer for two-stage revision of infected total knee arthroplasty
    Sandro Kohl
    Department of Orthopaedic Surgery, Inselspital, University of Bern, Switzerland
    Knee 18:464-9. 2011
    ..The use of this spacer is a time sparing, cheap and convenient option in 2-stage TKA revision...
  19. ncbi Shrinkage stresses in bone cement
    J F Orr
    School of Mechanical and Manufacturing Engineering, Queen s University Belfast, Ashby Building, Stranmillis Road, Belfast BT9 5AH, UK
    Biomaterials 24:2933-40. 2003
    ..Moduli of elasticity values were measured for acrylic bone cements ranging from 2.1 to 2.7GPa, as were Poisson's ratio values ranging from 0.38 to 0.46...
  20. ncbi Early radiographic and clinical results of balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures
    Frank M Phillips
    The University of Chicago Spine Center, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 28:2260-5; discussion 2265-7. 2003
    ..A prospective consecutive cohort study of clinical and radiographic outcomes after kyphoplasty for treatment of osteoporotic vertebral compression fractures...
  21. ncbi Development of specimen-specific finite element models of human vertebrae for the analysis of vertebroplasty
    V N Wijayathunga
    School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 222:221-8. 2008
    ....
  22. pmc In vitro activities of daptomycin-, vancomycin-, and teicoplanin-loaded polymethylmethacrylate against methicillin-susceptible, methicillin-resistant, and vancomycin-intermediate strains of Staphylococcus aureus
    Yuhan Chang
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Antimicrob Agents Chemother 55:5480-4. 2011
    The objective of this study was to evaluate the antibacterial effects of polymethylmethacrylate (PMMA) bone cements loaded with daptomycin, vancomycin, and teicoplanin against methicillin-susceptible Staphylococcus aureus (MSSA), ..
  23. ncbi Biomechanical study of pedicle screw fixation in severely osteoporotic bone
    Stephen D Cook
    Tulane University Health Sciences Center, Department of Orthopaedic Surgery, 1430 Tulane Avenue, SL 32, New Orleans, LA 70112, USA
    Spine J 4:402-8. 2004
    ..An expandable pedicle screw design has been shown to significantly improve fixation compared to a conventional screw in poor quality bone...
  24. ncbi Bone cement implantation syndrome
    A J Donaldson
    Department of Anaesthesia, University Hospital of South Manchester, Southmoor Road, Manchester M23 9LT, UK
    Br J Anaesth 102:12-22. 2009
    ..Invasive anaesthetic monitoring should be considered during cemented arthroplasty in high risk patients...
  25. pmc Two-stage total hip arthroplasty: how often does it control methicillin-resistant infection?
    Fay Leung
    Department of Orthopaedics, University of British Columbia, 3114 910 West 10th Avenue, Vancouver, BC V5Z 4E3, Canada
    Clin Orthop Relat Res 469:1009-15. 2011
    ..Methicillin-resistant hip infections are increasingly common. Reports of the surgical management of these patients using two-stage THA show variable control of infection, but all reports used static spacers...
  26. ncbi Mixed-mode failure strength of implant-cement interface specimens with varying surface roughness
    J Zelle
    Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 44:780-3. 2011
    ..The findings presented in this paper can be used in numerical models to simulate loosening at the implant-cement interface...
  27. ncbi Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate
    Tadashi Tsukeoka
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biomaterials 27:3897-903. 2006
    ..The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation...
  28. ncbi Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures: a prospective randomized trial with early follow-up
    Joseph P Deangelis
    Department of Orthopaedics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Orthop Trauma 26:135-40. 2012
    ..To prospectively compare the functional outcome associated with cemented and uncemented hemiarthroplasty...
  29. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  30. ncbi The Harris-Galante porous-coated, hemispherical, polyethylene-lined acetabular component in patients under 50 years of age: a 12- to 16-year review
    M R Utting
    Royal Perth Rehabilitation Hospital, 6 Selby Street, Shenton Park, Western Australia 6008, Australia
    J Bone Joint Surg Br 90:1422-7. 2008
    ..5 to 93.5) and for impending revision 55.3% (95% confidence interval 40.6 to 70) at 16 years. Uncemented acetabular components with polyethylene liners undergo silent lysis and merit regular long-term radiological review...
  31. ncbi Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength
    Daniel J Burval
    Cleveland Clinic Foundation, Cleveland Clinic Spine Institute, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 32:1077-83. 2007
    ..Pedicle screw pullout testing in osteoporotic and control human cadaveric vertebrae, comparing augmented and control vertebrae...
  32. ncbi Injectable PLGA microsphere/calcium phosphate cements: physical properties and degradation characteristics
    W J E M Habraken
    Department of Periodontology and Biomaterials, College of Dental Science, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomater Sci Polym Ed 17:1057-74. 2006
    ..In conclusion, all physical parameters were well within workable ranges with both 10:90 and 20:80 PLGA microsphere/CaP cements. After 12 weeks the PLGA was totally degraded and a highly porous, but strong scaffold remained...
  33. pmc 18 years of results with cemented primary hip prostheses in the Norwegian Arthroplasty Register: concerns about some newer implants
    Birgitte Espehaug
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop 80:402-12. 2009
    ..We studied long-term outcome based on data in the Norwegian Arthroplasty Register...
  34. ncbi Pullout strength of pedicle screws augmented with particulate calcium phosphate: an experimental study
    Ata Hashemi
    Department of Mechanical Engineering, McMaster University, 1280 Main Street, Hamilton, ON L8L 568, Canada
    Spine J 9:404-10. 2009
    Pressure-injected and in situ curing bone cements have been studied as alternatives in augmenting lumbar pedicle screw fixation but are frequently found to leak outside the confines of the target vertebra.
  35. pmc Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo
    Konstantinos Anagnostakos
    Klinik fur Orthopadie und Orthopadische Chirurgie, Universitat des Saarlandes, Homburg Saar, Germany
    Acta Orthop 80:193-7. 2009
    ..However, little is known about antibiotic elution from bone cement beyond the first 2-3 postoperative days in humans...
  36. ncbi New fractures after vertebroplasty: adjacent fractures occur significantly sooner
    A T Trout
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    AJNR Am J Neuroradiol 27:217-23. 2006
    ..We specifically hypothesized that subsequent fractures would occur sooner and more frequently in the vertebrae adjacent to the treated level...
  37. ncbi Biomechanical evaluation of vertebroplasty and kyphoplasty with polymethyl methacrylate or calcium phosphate cement under cyclic loading
    Hans Joachim Wilke
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
    Spine (Phila Pa 1976) 31:2934-41. 2006
    ..We developed a new method to simulating in vivo dynamic loading as closely as possible, which allows comparison of kyphoplasty and vertebroplasty, as well as augmentation materials...
  38. ncbi Cemented tibial component fixation performs better than cementless fixation: a randomized radiostereometric study comparing porous-coated, hydroxyapatite-coated and cemented tibial components over 5 years
    Ake Carlsson
    Department of Orthopedicsy, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Acta Orthop 76:362-9. 2005
    ....
  39. ncbi Percutaneous vertebroplasty: history, technique and current perspectives
    I G Hide
    Department of Radiology, Freeman Hospital, Newcastle upon Tyne, UK
    Clin Radiol 59:461-7. 2004
    ..NICE guidelines are now available for this procedure, which is relatively new in the UK, but has been performed for more than 15 years in continental Europe...
  40. ncbi Biomechanical comparison of kyphoplasty with different bone cements
    Seiji Tomita
    Orthopaedic Instrumentation Laboratory, Department of Orthopaedic Surgery, Johns Hopkins University Johns Hopkins Bay view Medical Center, Baltimore, MD 21224 2780, USA
    Spine (Phila Pa 1976) 29:1203-7. 2004
    ..Ex vivo biomechanical study...
  41. ncbi Comparison of total hip arthroplasty performed with and without cement : a randomized trial
    Andreas Laupacis
    Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Bone Joint Surg Am 84:1823-8. 2002
    ..This study was designed to compare the fixation of a Mallory-Head total hip prosthesis with and without cement...
  42. ncbi Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles
    Zhilong Shi
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge, Singapore 119260, Singapore
    Biomaterials 27:2440-9. 2006
    ..The inhibition of S. aureus and S. epidermidis growth on the surface of the CS NP and QCS NP-loaded bone cements was clearly shown using the LIVE/DEAD Baclight bacterial viability kits and fluorescence microscopy...
  43. ncbi Effect of postoperative mechanical axis alignment on the fifteen-year survival of modern, cemented total knee replacements
    Sebastien Parratte
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Bone Joint Surg Am 92:2143-9. 2010
    ..We hypothesized that a postoperative mechanical axis of 0° ± 3° would result in better long-term survival of total knee arthroplasty implants as compared with that in a group of outliers...
  44. pmc Antibiotic-loaded bone cement spacers in two-stage management of infected total knee arthroplasty
    R P Pitto
    Department of Orthopaedic Surgery, South Auckland Clinical School, University of Auckland, Auckland, New Zealand
    Int Orthop 28:129-33. 2004
    ..Last but not the least, the cost of spacers represents only a small fraction of the total expenses for management of infected knee arthroplasties...
  45. ncbi Infection of orthopedic implants and the use of antibiotic-loaded bone cements. A review
    H van de Belt
    Department of Orthopedic Surgery, University Hospital Groningen, The Netherlands
    Acta Orthop Scand 72:557-71. 2001
    ..made to prevent and cure orthopedic implant infections by incorporating antibiotics in polymethylmethacrylate bone cements, in primary and revision surgery...
  46. ncbi Is there a difference in perioperative mortality between cemented and uncemented implants in hip fracture surgery?
    M Hossain
    Department of Trauma and Orthopaedics, Ysbyty Gwynedd Hospital, Penrhosgarnedd Road, Bangor LL57 2LW, Wales, UK
    Injury 43:2161-4. 2012
    ..We compared the incidence and pattern of 48 h perioperative mortality between patients receiving cemented and uncemented implants after hip fracture surgery...
  47. ncbi Temperature elevation after vertebroplasty with polymethyl-methacrylate in the goat spine
    Jorrit Jan Verlaan
    Department of Orthopaedics, University Medical Center Utrecht, The Netherlands
    J Biomed Mater Res B Appl Biomater 67:581-5. 2003
    ..0 and 37.5 degrees C, respectively. The local temperature measured after in vivo vertebroplasty did not reach values that are known to cause tissue necrosis...
  48. ncbi Antimicrobial activity of gentamicin palmitate against high concentrations of Staphylococcus aureus
    Clemens Kittinger
    Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria
    J Mater Sci Mater Med 22:1447-53. 2011
    ..Both pre and post operative systemic antibiotic treatment and gentamicin containing bone cements (polymethylmethacrylate, PMMA) are commonly used strategies to overcome infections...
  49. ncbi Characterization of daptomycin-loaded antibiotic cement
    Lige Kaplan
    Department of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan 48073, USA
    Orthopedics 35:e503-9. 2012
    ..Based on the findings of our study, 2 g of daptomycin and 3.6 g of tobramycin per 40-g packet of cement should be used to promote daptomycin elution without sacrificing PMMA mechanical properties...
  50. ncbi Antibiotic-loaded bone cement reduces deep infection rates for primary reverse total shoulder arthroplasty: a retrospective, cohort study of 501 shoulders
    Robert J Nowinski
    Orthopaedic and Neurological Consultants, Inc, New Albany, OH 43054, USA
    J Shoulder Elbow Surg 21:324-8. 2012
    ..We conducted a retrospective cohort study to evaluate the effect of antibiotic-loaded bone cement vs plain bone cement on the prevention of deep infection after primary reverse total shoulder arthroplasty...
  51. ncbi Evaluation of the ultrasonication process for injectability of hydraulic calcium phosphate pastes
    Mohamed Habib
    Laboratoire de Biomecanique, Département de Génie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1K 2R1
    Acta Biomater 8:1164-8. 2012
    ..4 ± 2.3% without ultrasonication to 97.3 ± 2.4% with 30%. This result shows that ultrasonication is an effective solution to improve injectability...
  52. ncbi Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering
    Han Guo
    Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China
    Acta Biomater 5:268-78. 2009
    ..However, the CDHA scaffolds showed as good biocompatibility and osteogenicity as the hybrid ones at 8 weeks. These results indicate that the CDHA scaffolds fulfill the basic requirements of bone tissue engineering scaffold...
  53. ncbi Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration
    Fan Wu
    Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    Acta Biomater 4:1873-84. 2008
    ....
  54. pmc A randomized trial of vertebroplasty for osteoporotic spinal fractures
    David F Kallmes
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    N Engl J Med 361:569-79. 2009
    ..Vertebroplasty is commonly used to treat painful, osteoporotic vertebral compression fractures...
  55. pmc Porous surface modified bioactive bone cement for enhanced bone bonding
    Qiang He
    Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 7:e42525. 2012
    ..Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after ..
  56. ncbi Cardiac perforation and tricuspid regurgitation as a complication of percutaneous vertebroplasty
    Kuk Hui Son
    Department of Thoracic and Cardiovascular Surgery, Korea University Medical Center, Seoul, Republic of Korea
    Eur J Cardiothorac Surg 33:508-9. 2008
    ....
  57. pmc Micro and nano MgO particles for the improvement of fracture toughness of bone-cement interfaces
    MORSHED KHANDAKER
    Department of Engineering and Physics, University of Central Oklahoma, Edmond, OK 73034, USA
    J Biomech 46:1035-9. 2013
    ..0001). Results indicated that the addition of the micro and nano MgO particles to PMMA improved the quality of bone-cement union...
  58. ncbi Anterior spinal column augmentation with injectable bone cements
    Jorrit Jan Verlaan
    Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Biomaterials 27:290-301. 2006
    ..In this paper, both vertebroplasty and balloon vertebroplasty and their respective indications, techniques and results are described in relation with the application and limitations of permanent and resorbable injectable bone cements.
  59. pmc Asymptomatic diffuse pulmonary embolism caused by acrylic cement: an unusual complication of percutaneous vertebroplasty
    J Bernhard
    Department of Rheumatology and Clinical Immunology Allergology, University Hospital, CH 3010 Berne, Switzerland
    Ann Rheum Dis 62:85-6. 2003
  60. ncbi The biomechanical effects of kyphoplasty on treated and adjacent nontreated vertebral bodies
    Marta L Villarraga
    Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    J Spinal Disord Tech 18:84-91. 2005
    ..Therefore, subsequent adjacent level fractures may be related to the underlying etiology (weakening of the bone) rather than the surgical intervention...
  61. ncbi Bone cement with reduced proportion of monomer in total hip arthroplasty: preclinical evaluation and randomized study of 47 cases with 5 years' follow-up
    B Nivbrant
    Department of Orthopedics, NUS, University Hospital of Northern Sweden, Umea
    Acta Orthop Scand 72:572-84. 2001
    ..Collagen markers (PICP, ICTP) showed similar increases in bone turnover 6 weeks and 6 months after operation in both groups...
  62. ncbi Prophylaxis and treatment of implant-related infections by local application of antibiotics
    Michael Diefenbeck
    Klinik fur Unfall und Wiederherstellungschirurgie, Berufsgenossenschaftliche Kliniken Bergmannstrost, Halle Saale, Germany
    Injury 37:S95-104. 2006
    ..The second part discusses the role of local antibiotics such as gentamicin PMMA beads, and gentamicin-collagen and antibiotic-loaded cement spacers in treating implant-related infections...
  63. ncbi Aseptic loosening, not only a question of wear: a review of different theories
    Mikael Sundfeldt
    Department of Biomaterials Handicap Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Acta Orthop 77:177-97. 2006
    ..In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory...
  64. ncbi Quality assurance guidelines for percutaneous vertebroplasty
    Afshin Gangi
    Department of Radiology, University Louis Pasteur, Strasbourg, France
    Cardiovasc Intervent Radiol 29:173-8. 2006
  65. ncbi Balloon kyphoplasty and vertebroplasty for vertebral compression fractures: a comparative systematic review of efficacy and safety
    Rod S Taylor
    Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, United Kingdom
    Spine (Phila Pa 1976) 31:2747-55. 2006
    ..Systematic review and meta-regression...
  66. pmc Renal cement embolism during percutaneous vertebroplasty
    Seung Eun Chung
    Department of Diagnostic Radiology, Wooridul Spine Hospital, Seoul, Republic of Korea
    Eur Spine J 15:590-4. 2006
    ..leakage occurred outside of the anterior cortical fracture site of the L1 vertebral body, and multiple tubular bone cements migrated to the course of the renal vessels via the valveless collateral venous network surrounding the L1 body...
  67. ncbi Physico-chemical-mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates
    Marion Julien
    INSERM, U 791, 1 place A Ricordeau, Nantes, F 44042, France
    Biomaterials 28:956-65. 2007
    ..The total porosity of Mg-CPC was greater compared to Zn-CPC or F-CPC. Osteoblast-like cells, MC3T3-E1, remained viable and maintained their ability to express alkaline phosphatase in contact with the CPCs with doped ACCPs...
  68. pmc Intraoperative molds to create an articulating spacer for the infected knee arthroplasty
    Geoffrey S Van Thiel
    Rush University Medical Center, 1611 West Harrison Street, Suite 300, Chicago, IL 60612, USA
    Clin Orthop Relat Res 469:994-1001. 2011
    ....
  69. ncbi In vitro elution of vancomycin from calcium phosphate cement
    Tomoyuki Sasaki
    Department of Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan
    J Arthroplasty 20:1055-9. 2005
    ..From this study, we concluded that VCM-impregnated CPC might be an effective material for the treatment of osteomyelitis and/or prosthesis infection...
  70. pmc Articulating spacers used in two-stage revision of infected hip and knee prostheses abrade with time
    Bernd Fink
    Clinic of Joint Replacement, General and Rheumatic Orthopaedics, Orthopaedic Clinic Markgröningen gGmbH, Kurt Lindemann Weg 10, 71706 Markgröningen, Germany
    Clin Orthop Relat Res 469:1095-102. 2011
    ..Articulating spacers used in two-stage revision surgery of infected prostheses have the potential to abrade and subsequently induce third-body wear of the new prosthesis...
  71. ncbi Vertebroplasty by use of a strontium-containing bioactive bone cement
    Kenneth M C Cheung
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, China
    Spine (Phila Pa 1976) 30:S84-91. 2005
    ..A review of the laboratory and clinical data for a new strontium-containing hydroxyapatite bioactive bone cement...
  72. ncbi Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles
    Dennis P Link
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 29:675-82. 2008
    ..The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-beta1 significantly enhances the bone remodeling process...
  73. ncbi The operation of the century: total hip replacement
    Ian D Learmonth
    Department of Orthopaedics, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Lancet 370:1508-19. 2007
    ..Universal economic constraints in healthcare services dictate that further developments in total hip replacement will be governed by their cost-effectiveness...
  74. ncbi Percutaneous vertebroplasty for the treatment of burst fractures. Case report
    Jyi Feng Chen
    Department of Neurosurgery, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
    J Neurosurg Spine 1:228-31. 2004
    ..The authors propose this procedure as a useful intervention in selected patients with lumbar burst fractures. The complications associated with major surgical procedures are absent...
  75. ncbi Bioactive cement or ceramic/porous coating vs. conventional cement to obtain early stability of the acetabular cup. Randomised study of 96 hips followed with radiostereometry
    Georgios Digas
    Department of Orthopaedics, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    J Orthop Res 22:1035-43. 2004
    ..Uncemented cups had less radiolucent lines at 2 years. Fluoride containing cement or uncemented fixation did not improve the early postoperative stability of the socket...
  76. ncbi Total hip arthroplasty for primary osteoarthrosis in younger patients in the Finnish arthroplasty register. 4,661 primary replacements followed for 0-22 years
    Antti Eskelinen
    Department of Orthopedics, Surgical Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Acta Orthop 76:28-41. 2005
    ..Many studies have found a higher risk of revision after hip arthroplasty in younger patients. We evaluated the population-based survival of total hip arthroplasty (THA) in patients under 55 years of age and the factors affecting survival...
  77. ncbi High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection
    Paloma Anguita-Alonso
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Orthop Relat Res 439:43-7. 2005
    ..The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection...
  78. ncbi Finite element and experimental models of cemented hip joint reconstructions can produce similar bone and cement strains in pre-clinical tests
    J Stolk
    Orthopaedic Research Laboratory, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, Netherlands
    J Biomech 35:499-510. 2002
    ..The objective of overall agreement within 10% was achieved, indicating that both FE models were successfully validated. This prerequisite for accurately predicting long-term failure has been satisfied...
  79. ncbi Calcium-phosphate-silicate composite bone cement: self-setting properties and in vitro bioactivity
    Zhiguang Huan
    Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, People s Republic of China
    J Mater Sci Mater Med 20:833-41. 2009
    ..With good hydraulic properties, improved biocompatibility and moderate degradability, the novel DCPD/C(3)S bone cement may be a potential candidate as bone substitute...
  80. ncbi Cement augmentation of intertrochanteric fractures stabilised with intramedullary nailing
    C Dall'Oca
    Department of Orthopaedic and Traumatology, University of Verona, G B Rossi Hospital, Piazzale Scuro 10, 37134 Verona, Italy
    Injury 41:1150-5. 2010
    ..We believe that in femoral intertrochanteric fractures cement augmentation could improve the mechanical stability of the implant, ensuring early functional recovery...
  81. ncbi Alginate/poly (lactic-co-glycolic acid)/calcium phosphate cement scaffold with oriented pore structure for bone tissue engineering
    Xiaopeng Qi
    Key Laboratory of Specially Functional Materials, Ministry of Education, South China University of Technology, Guangzhou 510641, China
    J Biomed Mater Res A 89:980-7. 2009
    ..Alginate/PLGA/CPC scaffold preserved the open directional macropores and might be a potential scaffold for bone tissue engineering...
  82. pmc Multi-axial loading micromechanics of the cement-bone interface in postmortem retrievals and lab-prepared specimens
    Mark A Miller
    SUNY Upstate Medical University, Syracuse, NY, USA
    J Mech Behav Biomed Mater 4:366-74. 2011
    ..The magnitude of the compliance could be modified to simulate immediate post-operative conditions (using laboratory prepared data set) or long-term remodeling (using postmortem data set)...
  83. ncbi Vertebroplasty and kyphoplasty: reasons for concern?
    Luca Denaro
    Department of Neurosurgery, Catholic University School of Medicine, Policlinico Gemelli, Largo Gemelli 8, 00168 Rome, Italy
    Orthop Clin North Am 40:465-71, viii. 2009
    ..This article provides an overview of the state of the art in vertebroplasty and kyphoplasty, discussing the indications, techniques, results, and pitfalls...
  84. ncbi A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures
    Rachelle Buchbinder
    Monash Department of Clinical Epidemiology, Cabrini Hospital, and Monash University, Malvern, Vic, Australia
    N Engl J Med 361:557-68. 2009
    ..Vertebroplasty has become a common treatment for painful osteoporotic vertebral fractures, but there is limited evidence to support its use...
  85. ncbi Vesselplasty: a new technical approach to treat symptomatic vertebral compression fractures
    Lucía Flors
    Department of Radiology, Hospital Universitario Doctor Peset, Avd Gaspar Aguilar 90, Valencia 46017, Spain
    AJR Am J Roentgenol 193:218-26. 2009
    ..The objective of our study was to evaluate the effectiveness and safety of vesselplasty to treat symptomatic vertebral compression fractures (VCFs)...
  86. ncbi The long-term results of the original Exeter polished cemented femoral component: a follow-up report
    Robin S M Ling
    Princess Elizabeth Orthopaedic Centre Exeter, United Kingdom
    J Arthroplasty 24:511-7. 2009
    ..With the end point reoperation for aseptic stem loosening, the survivorship is 93.5% (95% confidence interval, 90.0%-97.0%). The reoperation rate for aseptic femoral component loosening is 3.23% into the 33rd year of follow-up...
  87. ncbi The cytocompatibility and early osteogenic characteristics of an injectable calcium phosphate cement
    Dennis P Link
    Radboud University Nijmegen Medical Center, Department of Periodontology and Biomaterials, Nijmegen, The Netherlands
    Tissue Eng 13:493-500. 2007
    ..In contrast to in vivo studies, the Calcibon CaP cement is not suitable as a scaffold for cell-based tissue-engineering strategies...
  88. ncbi Metal-backed acetabular components with conventional polyethylene: a review of 9113 primary components with a follow-up of 20 years
    G Hallan
    Department of Orthopaedic Surgery, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway geir hallan helse bergen no
    J Bone Joint Surg Br 92:196-201. 2010
    ..None of the metal-backed uncemented acetabular components with ultra-high-molecular-weight polyethylene liners in our study had satisfactory long-term results because of high rates of wear, osteolysis, aseptic loosening and dislocation...
  89. pmc The influence of cement viscosity on the early migration of a tapered polished femoral stem
    S Glyn-Jones
    Oxford Orthopaedic Engineering Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Int Orthop 27:362-5. 2003
    ..For a polished, tapered implant that is designed to subside, cement viscosity does not influence the 1-year migration, and it is therefore unlikely to affect long-term outcome...
  90. ncbi Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pullout strength
    Michael T Rohmiller
    Vanderbilt University, Department of Orthopedics and Rehabilitation, Vanderbilt University Spine Center, Nashville, TN, USA
    Spine J 2:255-60. 2002
    ..Calcium sulfate is an alternative to PMMA, because it lacks the exothermic reaction, is potentially osteoconductive and is resorbed by the body in 30 to 60 days...
  91. ncbi Addressing severe bone deficiency: what a cage will not do
    Wayne G Paprosky
    Department of Orthopaedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois
    J Arthroplasty 22:111-5. 2007
    ..Deficiencies of acetabular bone can be independently addressed and reconstructed providing initial stability and, we believe, long-term biologic fixation to host bone...
  92. ncbi Augmentation of pedicle screw fixation strength using an injectable calcium sulfate cement: an in vivo study
    Xiaodong Yi
    Department of Orthopedic Surgery, Peking University First Hospital, Beijing, China
    Spine (Phila Pa 1976) 33:2503-9. 2008
    ..An in vivo landrace model of cement augmentation of pedicle screw was established, and axial pull-out tests and histological analysis were performed...
  93. ncbi The rates of osteolysis and loosening associated with a modular posterior stabilized knee replacement. Results at five to fourteen years
    Paul F Lachiewicz
    Department of Orthopaedics, University of North Carolina, Chapel Hill, 242 Burnett Womack Building, CB 7055, Chapel Hill, NC 27599, USA
    J Bone Joint Surg Am 86:525-30. 2004
    ..The purpose of the present study was to evaluate a modular posterior stabilized prosthesis to determine its clinical performance as well as the rates of component loosening and osteolysis...
  94. pmc Assessment of different screw augmentation techniques and screw designs in osteoporotic spines
    S Becker
    Spine Centre, Orthopaedic Hospital Speising, Vienna, Austria
    Eur Spine J 17:1462-9. 2008
    ..Nevertheless, using a properly designed perforated screw will facilitate augmentation and instrumentation in osteoporotic spines...
  95. ncbi Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy
    Wolfgang T Becker
    Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
    J Bone Joint Surg Am 90:1060-7. 2008
    ..The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence of various factors of tumor presentation on those rates...
  96. ncbi Giant-cell tumor of the distal forearm
    Neil G Harness
    Orthopaedic Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hand Surg Am 29:188-93. 2004
    ..We have studied the results from our institution for 49 patients with giant-cell tumors of the distal forearm treated from 2 to 28 years (mean, 14 +/- 7 years) and compared the results for different methods of treatment...
  97. pmc Micro-mechanical modeling of the cement-bone interface: the effect of friction, morphology and material properties on the micromechanical response
    Dennis Janssen
    Radboud University Nijmegen Medical Centre, Orthopaedic Research Laboratory, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 41:3158-63. 2008
    ..The current study provides information that may help to better understand the load-transfer mechanisms taking place at the cement-bone interface...
  98. ncbi Clinical effectiveness of antibiotic-impregnated cement spacers for the treatment of infected implants of the hip joint
    Kengo Yamamoto
    Department of Orthopedic Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Orthop Sci 8:823-8. 2003
    ..All revision surgeries were performed using a two-stage procedure. No infection has recurred at a mean follow-up of 3 years 2 months...
  99. ncbi Documentation of hip prostheses used in Norway: a critical review of the literature from 1996--2000
    Arild Aamodt
    Department of Orthopaedic Surgery, Trondheim University Hospital, Trondheim
    Acta Orthop Scand 75:663-76. 2004
    ....
  100. ncbi All-polyethylene vs. metal-backed tibial component in total knee arthroplasty-a randomized RSA study comparing early fixation of horizontally and completely cemented tibial components: part 1. Horizontally cemented components: AP better fixated than MB
    Hans Hyldahl
    Department of Orthopaedics, St Goran s Hospital, SE 112 81 Stockholm, Sweden
    Acta Orthop 76:769-77. 2005
    ..Furthermore, the tibial component can be either horizontally or completely cemented. We evaluated metal backing versus all-polyethylene using horizontal cementing technique...
  101. ncbi Polymethylmethacrylate augmentation of pedicle screw for osteoporotic spinal surgery: a novel technique
    Ming Chau Chang
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Spine (Phila Pa 1976) 33:E317-24. 2008
    ..A retrospective study to evaluate the clinical results of patients with osteoporosis and various spinal diseases treated surgically with polymethylmethacrylate (PMMA) augmented pedicle screw...

Research Grants29

  1. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
    ....
  2. A Novel Biomimetic Bone Cement For Immediately Loaded Dental Implants
    DAVID ALLEN GAUL; Fiscal Year: 2010
    ..Due to biological and mechanical reasons, the currently available bone cements such as poly(methyl methacrylate) cement and calcium phosphate cement typically used in the cemented orthopedic ..
  3. DEVELOPMENT OF PICKERING EMULSIONS AS INJECTABLE BONE GRAFTS
    ELIZABETH MARIE COSGRIFF-HERNANDEZ; Fiscal Year: 2013
    ..g., bone cements) or inability to withstand physiological loading (e.g., hydrogels)...
  4. Polyurethane Bone Cements for Total Hip Implants
    Ibrahim Sendijarevic; Fiscal Year: 2010
    ..The technology developed in this study has the potential to improve the lives of over 1.5 million new patients each year who undergo hip replacement surgeries. ..
  5. Bone cements for delivery of osteoinductive growth factors
    Jonathan A Hodges; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Bone cements are widely used in maxillofacial surgery, repair of cranial defects, and dental fillings...
  6. Calcium Phosphate Bone Cement Nanocomposites
    KENNETH LAWRENCE LAMBERT; Fiscal Year: 2010
    ..The current prosthesis fixation using PMMA bone cements has a market of about $200 million...
  7. INJECTABLE RESORBABLE BONE CEMENT
    JOSEPH GRESSER; Fiscal Year: 1999
    ..characterization of the candidate cements, 5) material loss by cure in aqueous medium, 6) in-vivo screening of bone cements of varying viscosities in rats, 7) in-vivo histological and mechanical evaluation in rabbits, and 8) in-vivo ..
  8. A NOVEL METAL-POLYMER COMPOSITE FOR AMALGAM REPLACEMENT
    Ivan Stangel; Fiscal Year: 2001
    ..They could be used for indirect restorative procedures in dentistry where metal appliances or single tooth restorations are bonded to enamel/dentin, or as bone cements in orthopedics when metal implants are used.
  9. BIODEGRADABLE POLYACTIDE-CO-GLYCOLIDE MEDICAL CEMENTS
    Larry Nichols; Fiscal Year: 2000
    ..As bone cements these new materials can also be expected to lead to products which dispense growth hormones and healing factors ..
  10. BIOACTIVE CALCIUM PHOSPHATE GLASSES FOR HYPERTHERMIA
    YONGREN PENG; Fiscal Year: 1993
    ..properties will make such glass ideal as filler to bone defects after curettage of bone tumors, as filler in bone cements, etc. at the same time it is used as thermoseeds...
  11. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2006
    ..Specific Aims: 1 To formulate sub-cement, which will be similar to conventional PMMA bone cements in terms of modulus, yield stress, and viscosity but will be substantially more susceptible to fatigue crack ..
  12. CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINS
    HUAKUN XU; Fiscal Year: 2002
    ....
  13. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  14. Rabbit Model for In Vivo Monitoring of Bone Structure
    Michael Voor; Fiscal Year: 2003
    ..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
  15. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    ..This has also been the basis for successful application and granting of Orphan-Drug designation for cytarabine (Ara-C) liposome injection (trade name: DepoCyt) for the treatment of gliomas. ..
  16. Improved Animal Modeling of Saccular Aneurysms
    David F Kallmes; Fiscal Year: 2010
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  17. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2008
    ..abstract_text> ..
  18. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  19. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
  20. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  21. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  22. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    ..The objective of Phase I is to demonstrate that the device restores normal spine biomechanics (range of motion and stiffness) and is durable in fatigue testing. ..
  23. Fibronectin Antagonists in Cranial Suture Formation
    Amr Moursi; Fiscal Year: 2006
    ..abstract_text> ..
  24. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  25. Outcomes of Furlow&Conventional Palatoplasty Procedures
    Robert Havlik; Fiscal Year: 2002
    ..In addition, there have been no studies on the palatal architecture parameters and their influence upon oronasal fistulae and velopharyngeal competence that have been published. ..
  26. Aging and Fatigue Crack Growth in Dentin
    DWAYNE DALE AROLA; Fiscal Year: 2010
    ..These achievements should reduce the incidence of restorative failures associated with tooth fracture, resulting in billions of dollars in savings of health care costs, as well as a reduction in human suffering. ..
  27. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..
  28. Fatigue and the Endurance Strength of Dentin
    Dwayne Arola; Fiscal Year: 2003
    ..Therefore, results from this study could have tremendous impact on the clinical techniques and procedures used for restorative dentistry. ..