bone cements

Summary

Summary: Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.

Top Publications

  1. ncbi Percutaneous vertebroplasty
    David F Kallmes
    Department of Radiology, University of Virginia Health Sciences Center, PO Box 800170, Charlottesville, VA 22908, USA
    Radiology 229:27-36. 2003
  2. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
  3. pmc A randomized trial of vertebroplasty for osteoporotic spinal fractures
    David F Kallmes
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    N Engl J Med 361:569-79. 2009
  4. ncbi Development of a strontium-containing hydroxyapatite bone cement
    Dagang Guo
    State Key Laboratory for Mechanical Behavior of Materials, Xi an Jiaotong University, Xianning Western Road No 28, Xi an, Shaan X 710049, China
    Biomaterials 26:4073-83. 2005
  5. pmc Giant cell tumor of bone: risk factors for recurrence
    Frank M Klenke
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Orthop Relat Res 469:591-9. 2011
  6. doi Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial
    Douglas Wardlaw
    Orthopaedic Department, Woodend Hospital, NHS Grampian, Aberdeen, UK
    Lancet 373:1016-24. 2009
  7. doi Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial
    Caroline A H Klazen
    Radiology, St Elisabeth Ziekenhuis, Tilburg, Netherlands
    Lancet 376:1085-92. 2010
  8. ncbi Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate
    Tadashi Tsukeoka
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biomaterials 27:3897-903. 2006
  9. doi Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures: a prospective randomized trial with early follow-up
    Joseph P Deangelis
    Department of Orthopaedics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Orthop Trauma 26:135-40. 2012
  10. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001

Detail Information

Publications266 found, 100 shown here

  1. ncbi Percutaneous vertebroplasty
    David F Kallmes
    Department of Radiology, University of Virginia Health Sciences Center, PO Box 800170, Charlottesville, VA 22908, USA
    Radiology 229:27-36. 2003
    ..Finally, the current state of evidence in support of the efficacy of vertebroplasty are discussed, with particular attention to the need for ongoing clinical trials...
  2. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
    ..Since the practice of using undocumented implants has not changed, the register will continue to survey these implants. We plan to assess the mid- and long-term results of implants that have so far had good short-term results...
  3. pmc A randomized trial of vertebroplasty for osteoporotic spinal fractures
    David F Kallmes
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    N Engl J Med 361:569-79. 2009
    ..Vertebroplasty is commonly used to treat painful, osteoporotic vertebral compression fractures...
  4. ncbi Development of a strontium-containing hydroxyapatite bone cement
    Dagang Guo
    State Key Laboratory for Mechanical Behavior of Materials, Xi an Jiaotong University, Xianning Western Road No 28, Xi an, Shaan X 710049, China
    Biomaterials 26:4073-83. 2005
    ....
  5. pmc Giant cell tumor of bone: risk factors for recurrence
    Frank M Klenke
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Orthop Relat Res 469:591-9. 2011
    ..However, the best treatment of these tumors and risk factors for recurrence remain controversial...
  6. doi Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial
    Douglas Wardlaw
    Orthopaedic Department, Woodend Hospital, NHS Grampian, Aberdeen, UK
    Lancet 373:1016-24. 2009
    ..Balloon kyphoplasty is a minimally invasive procedure for the treatment of painful vertebral fractures, which is intended to reduce pain and improve quality of life. We assessed the efficacy and safety of the procedure...
  7. doi Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial
    Caroline A H Klazen
    Radiology, St Elisabeth Ziekenhuis, Tilburg, Netherlands
    Lancet 376:1085-92. 2010
    ..We aimed to clarify whether vertebroplasty has additional value compared with optimum pain treatment in patients with acute vertebral fractures...
  8. ncbi Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate
    Tadashi Tsukeoka
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biomaterials 27:3897-903. 2006
    ..The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation...
  9. doi Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures: a prospective randomized trial with early follow-up
    Joseph P Deangelis
    Department of Orthopaedics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Orthop Trauma 26:135-40. 2012
    ..To prospectively compare the functional outcome associated with cemented and uncemented hemiarthroplasty...
  10. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  11. doi The Harris-Galante porous-coated, hemispherical, polyethylene-lined acetabular component in patients under 50 years of age: a 12- to 16-year review
    M R Utting
    Royal Perth Rehabilitation Hospital, 6 Selby Street, Shenton Park, Western Australia 6008, Australia
    J Bone Joint Surg Br 90:1422-7. 2008
    ..5 to 93.5) and for impending revision 55.3% (95% confidence interval 40.6 to 70) at 16 years. Uncemented acetabular components with polyethylene liners undergo silent lysis and merit regular long-term radiological review...
  12. ncbi Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength
    Daniel J Burval
    Cleveland Clinic Foundation, Cleveland Clinic Spine Institute, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 32:1077-83. 2007
    ..Pedicle screw pullout testing in osteoporotic and control human cadaveric vertebrae, comparing augmented and control vertebrae...
  13. ncbi Aseptic loosening, not only a question of wear: a review of different theories
    Mikael Sundfeldt
    Department of Biomaterials Handicap Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Acta Orthop 77:177-97. 2006
    ..In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory...
  14. pmc 18 years of results with cemented primary hip prostheses in the Norwegian Arthroplasty Register: concerns about some newer implants
    Birgitte Espehaug
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop 80:402-12. 2009
    ..We studied long-term outcome based on data in the Norwegian Arthroplasty Register...
  15. ncbi Cemented tibial component fixation performs better than cementless fixation: a randomized radiostereometric study comparing porous-coated, hydroxyapatite-coated and cemented tibial components over 5 years
    Ake Carlsson
    Department of Orthopedicsy, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Acta Orthop 76:362-9. 2005
    ....
  16. ncbi Vertebroplasty by use of a strontium-containing bioactive bone cement
    Kenneth M C Cheung
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, China
    Spine (Phila Pa 1976) 30:S84-91. 2005
    ..A review of the laboratory and clinical data for a new strontium-containing hydroxyapatite bioactive bone cement...
  17. ncbi Finite element and experimental models of cemented hip joint reconstructions can produce similar bone and cement strains in pre-clinical tests
    J Stolk
    Orthopaedic Research Laboratory, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, Netherlands
    J Biomech 35:499-510. 2002
    ..The objective of overall agreement within 10% was achieved, indicating that both FE models were successfully validated. This prerequisite for accurately predicting long-term failure has been satisfied...
  18. ncbi Calcium-phosphate-silicate composite bone cement: self-setting properties and in vitro bioactivity
    Zhiguang Huan
    Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, People s Republic of China
    J Mater Sci Mater Med 20:833-41. 2009
    ..With good hydraulic properties, improved biocompatibility and moderate degradability, the novel DCPD/C(3)S bone cement may be a potential candidate as bone substitute...
  19. doi Alginate/poly (lactic-co-glycolic acid)/calcium phosphate cement scaffold with oriented pore structure for bone tissue engineering
    Xiaopeng Qi
    Key Laboratory of Specially Functional Materials, Ministry of Education, South China University of Technology, Guangzhou 510641, China
    J Biomed Mater Res A 89:980-7. 2009
    ..Alginate/PLGA/CPC scaffold preserved the open directional macropores and might be a potential scaffold for bone tissue engineering...
  20. ncbi The operation of the century: total hip replacement
    Ian D Learmonth
    Department of Orthopaedics, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Lancet 370:1508-19. 2007
    ..Universal economic constraints in healthcare services dictate that further developments in total hip replacement will be governed by their cost-effectiveness...
  21. ncbi Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles
    Dennis P Link
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 29:675-82. 2008
    ..The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-beta1 significantly enhances the bone remodeling process...
  22. ncbi Hemiarthroplasty of the hip with and without cement: a randomized clinical trial
    Fraser Taylor
    Auckland City Hospital, Private Bag 92 024, Auckland Mail Centre, Auckland 1142, New Zealand
    J Bone Joint Surg Am 94:577-83. 2012
    ..The primary hypothesis of this study was that use of cement would provide better visual analog pain scores following this procedure in an elderly patient population...
  23. ncbi New fractures after vertebroplasty: adjacent fractures occur significantly sooner
    A T Trout
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    AJNR Am J Neuroradiol 27:217-23. 2006
    ..We specifically hypothesized that subsequent fractures would occur sooner and more frequently in the vertebrae adjacent to the treated level...
  24. doi Cement augmentation of intertrochanteric fractures stabilised with intramedullary nailing
    C Dall'Oca
    Department of Orthopaedic and Traumatology, University of Verona, G B Rossi Hospital, Piazzale Scuro 10, 37134 Verona, Italy
    Injury 41:1150-5. 2010
    ..We believe that in femoral intertrochanteric fractures cement augmentation could improve the mechanical stability of the implant, ensuring early functional recovery...
  25. pmc Multi-axial loading micromechanics of the cement-bone interface in postmortem retrievals and lab-prepared specimens
    Mark A Miller
    SUNY Upstate Medical University, Syracuse, NY, USA
    J Mech Behav Biomed Mater 4:366-74. 2011
    ..The magnitude of the compliance could be modified to simulate immediate post-operative conditions (using laboratory prepared data set) or long-term remodeling (using postmortem data set)...
  26. pmc A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases
    Ira J Miller
    Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison 300 Chicago, IL, 60612, USA
    Diagn Pathol 5:62. 2010
    ..Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT...
  27. ncbi Bioactive cement or ceramic/porous coating vs. conventional cement to obtain early stability of the acetabular cup. Randomised study of 96 hips followed with radiostereometry
    Georgios Digas
    Department of Orthopaedics, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    J Orthop Res 22:1035-43. 2004
    ..Uncemented cups had less radiolucent lines at 2 years. Fluoride containing cement or uncemented fixation did not improve the early postoperative stability of the socket...
  28. ncbi Total hip arthroplasty for primary osteoarthrosis in younger patients in the Finnish arthroplasty register. 4,661 primary replacements followed for 0-22 years
    Antti Eskelinen
    Department of Orthopedics, Surgical Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Acta Orthop 76:28-41. 2005
    ..Many studies have found a higher risk of revision after hip arthroplasty in younger patients. We evaluated the population-based survival of total hip arthroplasty (THA) in patients under 55 years of age and the factors affecting survival...
  29. ncbi Percutaneous vertebroplasty for the treatment of burst fractures. Case report
    Jyi Feng Chen
    Department of Neurosurgery, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
    J Neurosurg Spine 1:228-31. 2004
    ..The authors propose this procedure as a useful intervention in selected patients with lumbar burst fractures. The complications associated with major surgical procedures are absent...
  30. doi Vertebroplasty and kyphoplasty: reasons for concern?
    Luca Denaro
    Department of Neurosurgery, Catholic University School of Medicine, Policlinico Gemelli, Largo Gemelli 8, 00168 Rome, Italy
    Orthop Clin North Am 40:465-71, viii. 2009
    ..This article provides an overview of the state of the art in vertebroplasty and kyphoplasty, discussing the indications, techniques, results, and pitfalls...
  31. ncbi A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures
    Rachelle Buchbinder
    Monash Department of Clinical Epidemiology, Cabrini Hospital, and Monash University, Malvern, Vic, Australia
    N Engl J Med 361:557-68. 2009
    ..Vertebroplasty has become a common treatment for painful osteoporotic vertebral fractures, but there is limited evidence to support its use...
  32. ncbi High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection
    Paloma Anguita-Alonso
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Orthop Relat Res 439:43-7. 2005
    ..The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection...
  33. ncbi The cytocompatibility and early osteogenic characteristics of an injectable calcium phosphate cement
    Dennis P Link
    Radboud University Nijmegen Medical Center, Department of Periodontology and Biomaterials, Nijmegen, The Netherlands
    Tissue Eng 13:493-500. 2007
    ..In contrast to in vivo studies, the Calcibon CaP cement is not suitable as a scaffold for cell-based tissue-engineering strategies...
  34. doi The long-term results of the original Exeter polished cemented femoral component: a follow-up report
    Robin S M Ling
    Princess Elizabeth Orthopaedic Centre Exeter, United Kingdom
    J Arthroplasty 24:511-7. 2009
    ..With the end point reoperation for aseptic stem loosening, the survivorship is 93.5% (95% confidence interval, 90.0%-97.0%). The reoperation rate for aseptic femoral component loosening is 3.23% into the 33rd year of follow-up...
  35. pmc The influence of cement viscosity on the early migration of a tapered polished femoral stem
    S Glyn-Jones
    Oxford Orthopaedic Engineering Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Int Orthop 27:362-5. 2003
    ..For a polished, tapered implant that is designed to subside, cement viscosity does not influence the 1-year migration, and it is therefore unlikely to affect long-term outcome...
  36. doi Metal-backed acetabular components with conventional polyethylene: a review of 9113 primary components with a follow-up of 20 years
    G Hallan
    Department of Orthopaedic Surgery, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway geir hallan helse bergen no
    J Bone Joint Surg Br 92:196-201. 2010
    ..None of the metal-backed uncemented acetabular components with ultra-high-molecular-weight polyethylene liners in our study had satisfactory long-term results because of high rates of wear, osteolysis, aseptic loosening and dislocation...
  37. doi Vesselplasty: a new technical approach to treat symptomatic vertebral compression fractures
    Lucía Flors
    Department of Radiology, Hospital Universitario Doctor Peset, Avd Gaspar Aguilar 90, Valencia 46017, Spain
    AJR Am J Roentgenol 193:218-26. 2009
    ..The objective of our study was to evaluate the effectiveness and safety of vesselplasty to treat symptomatic vertebral compression fractures (VCFs)...
  38. ncbi Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pullout strength
    Michael T Rohmiller
    Vanderbilt University, Department of Orthopedics and Rehabilitation, Vanderbilt University Spine Center, Nashville, TN, USA
    Spine J 2:255-60. 2002
    ..Calcium sulfate is an alternative to PMMA, because it lacks the exothermic reaction, is potentially osteoconductive and is resorbed by the body in 30 to 60 days...
  39. ncbi Addressing severe bone deficiency: what a cage will not do
    Wayne G Paprosky
    Department of Orthopaedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois
    J Arthroplasty 22:111-5. 2007
    ..Deficiencies of acetabular bone can be independently addressed and reconstructed providing initial stability and, we believe, long-term biologic fixation to host bone...
  40. ncbi The rates of osteolysis and loosening associated with a modular posterior stabilized knee replacement. Results at five to fourteen years
    Paul F Lachiewicz
    Department of Orthopaedics, University of North Carolina, Chapel Hill, 242 Burnett Womack Building, CB 7055, Chapel Hill, NC 27599, USA
    J Bone Joint Surg Am 86:525-30. 2004
    ..The purpose of the present study was to evaluate a modular posterior stabilized prosthesis to determine its clinical performance as well as the rates of component loosening and osteolysis...
  41. pmc Assessment of different screw augmentation techniques and screw designs in osteoporotic spines
    S Becker
    Spine Centre, Orthopaedic Hospital Speising, Vienna, Austria
    Eur Spine J 17:1462-9. 2008
    ..Nevertheless, using a properly designed perforated screw will facilitate augmentation and instrumentation in osteoporotic spines...
  42. doi Augmentation of pedicle screw fixation strength using an injectable calcium sulfate cement: an in vivo study
    Xiaodong Yi
    Department of Orthopedic Surgery, Peking University First Hospital, Beijing, China
    Spine (Phila Pa 1976) 33:2503-9. 2008
    ..An in vivo landrace model of cement augmentation of pedicle screw was established, and axial pull-out tests and histological analysis were performed...
  43. pmc Micro-mechanical modeling of the cement-bone interface: the effect of friction, morphology and material properties on the micromechanical response
    Dennis Janssen
    Radboud University Nijmegen Medical Centre, Orthopaedic Research Laboratory, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 41:3158-63. 2008
    ..The current study provides information that may help to better understand the load-transfer mechanisms taking place at the cement-bone interface...
  44. ncbi Giant-cell tumor of the distal forearm
    Neil G Harness
    Orthopaedic Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hand Surg Am 29:188-93. 2004
    ..We have studied the results from our institution for 49 patients with giant-cell tumors of the distal forearm treated from 2 to 28 years (mean, 14 +/- 7 years) and compared the results for different methods of treatment...
  45. ncbi Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy
    Wolfgang T Becker
    Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
    J Bone Joint Surg Am 90:1060-7. 2008
    ..The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence of various factors of tumor presentation on those rates...
  46. ncbi Documentation of hip prostheses used in Norway: a critical review of the literature from 1996--2000
    Arild Aamodt
    Department of Orthopaedic Surgery, Trondheim University Hospital, Trondheim
    Acta Orthop Scand 75:663-76. 2004
    ....
  47. ncbi Clinical effectiveness of antibiotic-impregnated cement spacers for the treatment of infected implants of the hip joint
    Kengo Yamamoto
    Department of Orthopedic Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Orthop Sci 8:823-8. 2003
    ..All revision surgeries were performed using a two-stage procedure. No infection has recurred at a mean follow-up of 3 years 2 months...
  48. ncbi In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:617-27. 2002
    ..investigate in vitro the apoptosis- and/or necrosis-inducing potential of polymethylmethacrylate (PMMA)-based bone cements for prosthetic surgery...
  49. ncbi The use of cementless expansion acetabular component and an alumina-polyethylene bearing in total hip arthroplasty for osteonecrosis
    Y G Kim
    Department of Orthopaedic Surgery, Kyungpook National University School of Medicine, Sam Duck 2 Ga, 50, Jung Gu 700 721, Korea
    J Bone Joint Surg Br 87:776-80. 2005
    ..8% (95% confidence interval 0.956 to 1.000) at ten years. Our study has shown that the results of THA with a cementless expansion acetabular component and an alumina-polyethylene bearing surface are good...
  50. ncbi Staphylococcus aureus biofilm formation on different gentamicin-loaded polymethylmethacrylate bone cements
    H van de Belt
    Department of Orthopedic Surgery, University Hospital, Groningen, The Netherlands
    Biomaterials 22:1607-11. 2001
    In this in vitro study, the formation of a Staphylococcus aureus biofilm on six gentamicin-loaded bone cements (CMW1, CMW3, CMW Endurance, CMW2000, Palacos, and Palamed) was determined in a modified Robbins device over a 3 days time span ..
  51. ncbi Polymer--calcium phosphate cement composites for bone substitutes
    Rafal A Mickiewicz
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Biomed Mater Res 61:581-92. 2002
    ..The increased strength was attributed to the polymer's capacity to bridge between multiple crystallites (thus forming a more cohesive composite) and to absorb energy through plastic flow...
  52. ncbi Early failure of precoated femoral components in primary total hip arthroplasty
    Alvin Ong
    Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Bone Joint Surg Am 84:786-92. 2002
    ..Reports differ as to whether this step has increased or decreased the rate of failure. This study was designed to evaluate this issue...
  53. ncbi Resorbable cement for the augmentation of internally-fixed unstable trochanteric fractures. A prospective, randomised multicentre study
    P Mattsson
    Department of Orthopaedics, Uppsala University Hospital, S 75185 Uppsala, Sweden
    J Bone Joint Surg Br 87:1203-9. 2005
    ....
  54. ncbi Different loss of BMD using uncemented press-fit and whole polyethylene cups fixed with cement: repeated DXA studies in 96 hips randomized to 3 types of fixation
    Georgios Digas
    Department of Orthopedics, Sahlgrenska University Hospital, Goteborg, SE 413 45, Sweden
    Acta Orthop 77:218-26. 2006
    ....
  55. ncbi Fixation of the tibial component using CMW-1 or Palacos bone cement with gentamicin: similar outcome in a randomized radiostereometric study of 51 total knee arthroplasties
    Gunnar Adalberth
    Department of Orthopaedics, University of Uppsala, Sweden
    Acta Orthop Scand 73:531-8. 2002
    ..No complications occurred. Our findings suggest a need for more studies of CMW-1 bone cement containing gentamicin in a larger cohort of patients...
  56. ncbi All-polyethylene vs. metal-backed tibial component in total knee arthroplasty-a randomized RSA study comparing early fixation of horizontally and completely cemented tibial components: part 1. Horizontally cemented components: AP better fixated than MB
    Hans Hyldahl
    Department of Orthopaedics, St Goran s Hospital, SE 112 81 Stockholm, Sweden
    Acta Orthop 76:769-77. 2005
    ..Furthermore, the tibial component can be either horizontally or completely cemented. We evaluated metal backing versus all-polyethylene using horizontal cementing technique...
  57. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
    ..We present here an overview of bone grafts and graft substitutes available for clinical applications...
  58. ncbi Osteocalcin enhances bone remodeling around hydroxyapatite/collagen composites
    Stefan Rammelt
    Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Biomed Mater Res A 73:284-94. 2005
    ..This study supports the observations from in vitro studies that OC activates both osteoclasts and osteoblasts during early bone formation...
  59. doi The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats
    Esther W H Bodde
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 87:780-91. 2008
    ..Low amounts of sustained released rhBMP-2 were sufficient to bridge critically sized defects. A substantial amount of rhBMP-2 was retained in the implants because of the slow release rate and the limited degradation...
  60. ncbi Biomechanical study of pedicle screw fixation in severely osteoporotic bone
    Stephen D Cook
    Tulane University Health Sciences Center, Department of Orthopaedic Surgery, 1430 Tulane Avenue, SL 32, New Orleans, LA 70112, USA
    Spine J 4:402-8. 2004
    ..An expandable pedicle screw design has been shown to significantly improve fixation compared to a conventional screw in poor quality bone...
  61. ncbi Polymethylmethacrylate augmentation of pedicle screw for osteoporotic spinal surgery: a novel technique
    Ming Chau Chang
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Spine (Phila Pa 1976) 33:E317-24. 2008
    ..A retrospective study to evaluate the clinical results of patients with osteoporosis and various spinal diseases treated surgically with polymethylmethacrylate (PMMA) augmented pedicle screw...
  62. ncbi Preliminary outcomes and efficacy of the first 360 consecutive kyphoplasties for the treatment of painful osteoporotic vertebral compression fractures
    Mohammad E Majd
    Spine Surgery, PSC, 210 E Gray Street, Suite 601, Louisville, KY 40202, USA
    Spine J 5:244-55. 2005
    ..Kyphoplasty involves expanding an inflatable balloon tamp to create a cavity within a vertebral body before cement deposition...
  63. ncbi Injectability of calcium phosphate pastes
    Marc Bohner
    Dr H C Robert Mathys Foundation, Bischmattstrasse 12, CH 2544 Bettlach, Switzerland
    Biomaterials 26:1553-63. 2005
    ..This effect could be due to a change of the PL of the powder or to the lubricating effect of the polymer...
  64. pmc Cement leakage during vertebroplasty: an underestimated problem?
    R Schmidt
    Department of Orthopaedics and SCI, University of Ulm, Ulm, Germany
    Eur Spine J 14:466-73. 2005
    ..Therefore, CT scans should be obtained to calculate the exact leakage rate and to assess persistent or new pain occurring postoperatively...
  65. doi Calcium-phosphate and polymethylmethacrylate cement in long-term outcome after kyphoplasty of painful osteoporotic vertebral fractures
    Ingo A Grafe
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    Spine (Phila Pa 1976) 33:1284-90. 2008
    ..A comparative prospective trial evaluating 3-year outcome...
  66. ncbi Palamed G compared with Palacos R with gentamicin in Charnley total hip replacement. A randomised, radiostereometric study of 60 HIPS
    G Hallan
    Department of Orthopaedic Surgery, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway
    J Bone Joint Surg Br 88:1143-8. 2006
    We performed a randomised, radiostereometric study comparing two different bone cements, one of which has been sparsely clinically documented. Randomisation of 60 total hip replacements (57 patients) into two groups of 30 was undertaken...
  67. doi Percutaneous vertebroplasty and bone cement leakage: clinical experience with a new high-viscosity bone cement and delivery system for vertebral augmentation in benign and malignant compression fractures
    Giovanni Carlo Anselmetti
    Interventional Radiology Unit, Institute for Cancer Research and Treatment IRCC, Strada Provinciale no 142 km 3, 95, Candiolo, Turin, 10060, Italy
    Cardiovasc Intervent Radiol 31:937-47. 2008
    ..14) related to the disc. The high-viscosity PMMA system is safe and effective for clinical use, allowing a significant reduction of extravasation rate and, thus, leakage-related complications...
  68. doi Treatment options for recurrent giant cell tumors of bone
    Maurice Balke
    Department of Orthopedic Surgery, University of Muenster, Albert Schweitzer Str 33, 48149, Munster, Germany
    J Cancer Res Clin Oncol 135:149-58. 2009
    ..The possible surgical procedures range from repeated intralesional curettage to wide resection...
  69. pmc Changes in periprosthetic bone remodelling after redesigning an anatomic cementless stem
    Juan J Panisello
    Department of Orthopaedic Surgery, University Hospital Miguel Servet, Zaragoza, Spain
    Int Orthop 33:373-9. 2009
    ..These differences were noted at the end of the first post-operative year and remained stable, except in zone 7, where they were progressive. There is little evidence that the modified stem reduces femoral bone density loss...
  70. ncbi Rush pin technique for temporary antibiotic-impregnated cement prosthesis for infected total hip arthroplasty
    Robert L Barrack
    Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Arthroplasty 17:600-3. 2002
    ..The technique has been used successfully in many cases over a 5-year period...
  71. ncbi Cement mantle stress under retroversion torque at heel-strike
    B Afsharpoya
    School of Mechanical Engineering, The University of Leeds, West Yorkshire, UK
    Med Eng Phys 31:1323-30. 2009
    ....
  72. pmc A prospective randomised radiostereometric analysis trial of SmartSet HV and Palacos R bone cements in primary total hip arthroplasty
    Otto S Husby
    Orthopaedic Department, St Olavs Hospital, Trondheim University Hospital, Norway
    J Orthop Traumatol 11:29-35. 2010
    Introduction of new bone cements into clinical practice should include radiostereometric studies.
  73. ncbi Bone cement with reduced proportion of monomer in total hip arthroplasty: preclinical evaluation and randomized study of 47 cases with 5 years' follow-up
    B Nivbrant
    Department of Orthopedics, NUS, University Hospital of Northern Sweden, Umea
    Acta Orthop Scand 72:572-84. 2001
    ..Collagen markers (PICP, ICTP) showed similar increases in bone turnover 6 weeks and 6 months after operation in both groups...
  74. ncbi Comparison of total hip arthroplasty performed with and without cement : a randomized trial
    Andreas Laupacis
    Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Bone Joint Surg Am 84:1823-8. 2002
    ..This study was designed to compare the fixation of a Mallory-Head total hip prosthesis with and without cement...
  75. doi Combination radiofrequency ablation and cementoplasty for palliative treatment of painful neoplastic bone metastasis: experience with 53 treated lesions in 36 patients
    Michael David Lane
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W 12th Avenue, Vancouver, BC, V52 1M9, Canada
    Skeletal Radiol 40:25-32. 2011
    ..We report the safety and efficacy of combined radiofrequency ablation and cementoplasty in treating painful neoplastic bone lesions...
  76. doi Bilateral fatigue fracture of the femoral components in a cruciate-retaining cementless total knee prosthesis
    Shu Saito
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Orthopedics 34:e688-91. 2011
    ..In this case, failure of bone ingrowth in uncemented components, higher body mass index, and a higher athletic activity led to fatigue fracture of the femoral components...
  77. ncbi Thermal manipulation of bone cement
    William Jiranek
    Department of Orthopaedic Surgery, Virginia Commonwealth University Health System, Richmond, VA, USA
    Orthopedics 28:s863-6. 2005
    ....
  78. ncbi Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints
    I Takei
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Biomed Mater Res 52:613-20. 2000
    ..Thus, many MMP type enzymes possibly contribute to prosthetic loosening and osteolysis through pathologic extracellular matrix degradation and connective tissue/bone remodeling around prostheses...
  79. ncbi Modified PMMA cements for a hydrolysis resistant metal-polymer interface in orthopaedic applications
    U Gbureck
    Department for Functional Materials in Medicine and Dentistry, University of Wurzburg, Pleicherwall 2, D 97070 Wurzburg, Germany
    Acta Biomater 1:671-6. 2005
    ..The advantage of the modification of the cement matrix is an easy clinical applicability of the procedure maintaining the processing and implantation techniques of the cement material...
  80. doi Treatment of metastatic carcinoma to the hip with CT-guided percutaneous acetabuloplasty: report of four cases
    Bishnu H Sapkota
    Department of Radiology, Division of Neurointerventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Vasc Interv Radiol 20:548-52. 2009
    ..The procedure was well tolerated by each patient without morbidity. PA appears to be a reasonable palliative procedure for painful and fragile hips associated with metastatic bone disease...
  81. ncbi Combined cementoplasty and radiofrequency ablation in the treatment of painful neoplastic lesions of bone
    Peter L Munk
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W 12th Ave, Vancouver, BCV52 1M9 Canada
    J Vasc Interv Radiol 20:903-11. 2009
    ..To assess the safety and effectiveness of combined radiofrequency (RF) ablation and cementoplasty in the treatment of painful neoplastic lesions of bone...
  82. ncbi Extending polymerization time of polymethylmethacrylate cement in percutaneous vertebroplasty with ice bath cooling
    Ram Chavali
    Lahey Clinic Medical Center, Burlington, MA 01805, USA
    AJNR Am J Neuroradiol 24:545-6. 2003
    ..We have been using this technique since mid-1998, treating more than 600 vertebral bodies...
  83. doi Fixation of autogenous bone grafts with ethyl-cyanoacrylate glue or titanium screws in the calvaria of rabbits
    S Saska
    Biochemistry and Chemical Technology Department, Institute of Chemistry at Araraquara, UNESP, Brazil
    Int J Oral Maxillofac Surg 38:180-6. 2009
    ..The adhesive was biocompatible, presented similar stability to the screw and maintained the bone area, although there was a delay in graft incorporation...
  84. doi Rheological properties of calcium carbonate self-setting injectable paste
    C Combes
    Universite de Toulouse, CIRIMAT, UPS INPT CNRS, ENSIACET, 4, allée Emile Monso, BP 74233, 31432 Toulouse Cedex 4, France
    Acta Biomater 6:920-7. 2010
    ..5 kg, revealing the ease of injection of this CaCO(3) self-setting paste...
  85. ncbi Treatment of painful osteoporotic compression and burst fractures using kyphoplasty: a prospective observational design
    Michael Stoffel
    Department of Neurosurgery, Rheinische Friedrich Wilhelms University, Bonn, Germany
    J Neurosurg Spine 6:313-9. 2007
    ..The aim of this study was to test the hypothesis that kyphoplasty is an effective treatment in painful osteoporotic vertebral fractures, even with involvement of the posterior cortical wall...
  86. pmc Fatigue creep damage at the cement-bone interface: an experimental and a micro-mechanical finite element study
    Daan Waanders
    Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Biomech 42:2513-9. 2009
    ..76). This study shows the additional value of FEA of the cement-bone interface relative to experimental studies and can therefore be used to optimize its mechanical properties...
  87. ncbi Stability of pedicle screws after kyphoplasty augmentation: an experimental study to compare transpedicular screw fixation in soft and cured kyphoplasty cement
    Oliver Linhardt
    Orthopaedic Department, University Regensburg, Bad Abbach, Germany
    J Spinal Disord Tech 19:87-91. 2006
    ..The goal of this cadaver study was to compare the stability of pedicle screws after implantation in soft or cured kyphoplasty cement...
  88. ncbi 9- to 11-year results of cemented titanium mueller straight stem in total hip arthroplasty
    Bernd Baumann
    Department of Orthopedic Surgery, König Ludwig Haus, Julius Maximilians University, Wurzburg, Germany
    Orthopedics 30:551-7. 2007
    ..This titanium implant is recommended for patients with hypersensitivity to chrome, cobalt, and nickel. mplanting the biggest possible stem seems to be most beneficial...
  89. ncbi A study of the Elite Plus femoral component using radiostereometric analysis
    B Derbyshire
    Wrightington Wigan and Leigh NHS Trust, Centre for Hip Surgery Wrightington Hospital, Hall Lane, Appley Bridge WN6 9EP, UK
    J Bone Joint Surg Br 89:730-5. 2007
    ..We believe that the surgical technique, particularly the use of high-viscosity cement, may have been an important factor contributing to our results...
  90. doi Energy dispersive X-ray diffraction study of phase development during hardening of calcium phosphate bone cements with addition of chitosan
    J V Rau
    Istituto per lo Studio dei Materiali Nanostrutturati, CNR, Piazzale Aldo Moro, Rome, Italy
    Acta Biomater 4:1089-94. 2008
    The aim of this work was to study the phase transformation during the setting reaction of two calcium phosphate bone cements based on either alpha tricalcium phosphate (alpha-TCP) or tetracalcium phosphate (TetCP) initial solid phase, and ..
  91. ncbi Performance of bone cements: are current preclinical specifications adequate?
    Markus Nottrott
    Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop 79:826-31. 2008
    Current specifications (standards) for preclinical testing of bone cements (ISO 5833: 2002, ASTM F451-99a) require simple mechanical testing after ageing for 24 h under dry conditions at 23 degrees C...
  92. pmc Results of a cemented titanium alloy straight femoral shaft prosthesis after 10 years of follow-up
    C Eingartner
    BG Trauma Center, University of Tubingen, Germany
    Int Orthop 25:81-4. 2001
    ..Three stems showed radiological loosening but have not been revised. The average hip score was 85. The results are encouraging and comparable to other cemented femoral stems...
  93. ncbi The dynamic volume changes of polymerising polymethyl methacrylate bone cement
    Scott D Muller
    Department of Trauma and Orthopaedics, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Acta Orthop Scand 73:684-7. 2002
    ..Stable fixation of vacuum-mixed cement may depend on additional techniques to offset the altered volumetric behaviour of vacuum-mixed cement...
  94. ncbi New partially degradable and bioactive acrylic bone cements based on starch blends and ceramic fillers
    Ismael Espigares
    Department of Polymer Engineering, University of Minho, Braga, Portugal
    Biomaterials 23:1883-95. 2002
    This work reports the development of new partially biodegradable acrylic bone cements based on corn starch/cellulose acetate blends (SCA), prepared by the free radical polymerization of methyl methacrylate and acrylic acid at low ..
  95. ncbi Microsurgical interlaminary vertebro- and kyphoplasty for severe osteoporotic fractures
    Bronek M Boszczyk
    Departments of Neurosurgery and Radiology, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany
    J Neurosurg 100:32-7. 2004
    ..A microsurgical interlaminary approach for vertebro- and kyphoplasty was developed to allow spinal decompression and control of the spinal canal during augmentation...
  96. ncbi In vitro adherence and accumulation of Staphylococcus epidermidis RP 62 A and Staphylococcus epidermidis M7 on four different bone cements
    D P Konig
    Department of Orthopaedic Surgery, Cologne University, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Langenbecks Arch Surg 386:328-32. 2001
    ..In vitro studies of different bone cements containing antibiotics, developed for the prevention of biomaterial-associated infection, could not always ..
  97. pmc Augmentation of (pedicle) screws with calcium apatite cement in patients with severe progressive osteoporotic spinal deformities: an innovative technique
    P I Wuisman
    Department of Orthopaedic Surgery, Free University Teaching Hospital, Amsterdam, The Netherlands
    Eur Spine J 9:528-33. 2000
    ..No CAC-related complications were observed perioperatively. No implant migration was observed, and fusion was observed in all cases at follow-up examination performed at a mean of 32 months after surgery...
  98. doi Quantitative analysis of the effect of porosity on the fatigue strength of bone cement
    David Hoey
    Trinity Centre for Bioengineering, Department of Mechanical Engineering, Trinity College Dublin, Dublin, Ireland
    Acta Biomater 5:719-26. 2009
    ..Therefore, given the findings from this study, a possible step forward in the development of surgical bone cements may involve a compromise in which relatively small pores are evenly distributed throughout the material.
  99. ncbi Comparison of therapeutic effect between percutaneous vertebroplasty and kyphoplasty on vertebral compression fracture
    Jian Lin Zhou
    Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan 430060, China
    Chin J Traumatol 11:42-4. 2008
    ..To compare the clinical efficacy of percutaneous vertebroplasty (PVP) with percutaneous kyphoplasty (PKP) in the treatment of vertebral compression fracture (VCF)...
  100. ncbi Second-generation cementless total hip arthroplasty in patients with osteonecrosis of the femoral head
    Byung Woo Min
    Department of Orthopaedic Surgery, Dongsan Medical Center, Keimyung University, Joong Gu, Daegu, South Korea
    J Arthroplasty 23:902-10. 2008
    ..Second-generation femoral prostheses provide excellent fixation in patients with osteonecrosis of the femoral head. However, a high rate of polyethylene wear and osteolysis in these high-risk patients remains a challenging problem...
  101. ncbi Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method
    Susan M Renner
    Department of Bioengineering, The University of Illinois at Chicago, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 29:E212-6. 2004
    ..Axial pullout tests using fresh cadaveric thoracolumbar vertebral bodies...

Research Grants68

  1. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2009
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  2. Injectable and Strong Nano-Apatite/Stem Cell Scaffolds for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2010
    ....
  3. Injectable and Strong Nano-Apatite/Stem Cell Scaffolds for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2009
    ....
  4. A Novel Biomimetic Bone Cement For Immediately Loaded Dental Implants
    DAVID ALLEN GAUL; Fiscal Year: 2010
    ..Due to biological and mechanical reasons, the currently available bone cements such as poly(methyl methacrylate) cement and calcium phosphate cement typically used in the cemented orthopedic ..
  5. INJECTABLE RESORBABLE BONE CEMENT
    JOSEPH GRESSER; Fiscal Year: 1999
    ..characterization of the candidate cements, 5) material loss by cure in aqueous medium, 6) in-vivo screening of bone cements of varying viscosities in rats, 7) in-vivo histological and mechanical evaluation in rabbits, and 8) in-vivo ..
  6. Polyurethane Bone Cements for Total Hip Implants
    Ibrahim Sendijarevic; Fiscal Year: 2010
    ..The technology developed in this study has the potential to improve the lives of over 1.5 million new patients each year who undergo hip replacement surgeries. ..
  7. A NOVEL METAL-POLYMER COMPOSITE FOR AMALGAM REPLACEMENT
    Ivan Stangel; Fiscal Year: 2001
    ..They could be used for indirect restorative procedures in dentistry where metal appliances or single tooth restorations are bonded to enamel/dentin, or as bone cements in orthopedics when metal implants are used.
  8. BIODEGRADABLE POLYACTIDE-CO-GLYCOLIDE MEDICAL CEMENTS
    Larry Nichols; Fiscal Year: 2000
    ..As bone cements these new materials can also be expected to lead to products which dispense growth hormones and healing factors ..
  9. BIOACTIVE CALCIUM PHOSPHATE GLASSES FOR HYPERTHERMIA
    YONGREN PENG; Fiscal Year: 1993
    ..properties will make such glass ideal as filler to bone defects after curettage of bone tumors, as filler in bone cements, etc. at the same time it is used as thermoseeds...
  10. Calcium Phosphate Bone Cement Nanocomposites
    KENNETH LAWRENCE LAMBERT; Fiscal Year: 2010
    ..The current prosthesis fixation using PMMA bone cements has a market of about $200 million...
  11. Calcium Phosphate Bone Cement Nanocomposites
    KENNETH LAMBERT; Fiscal Year: 2009
    ..The current prosthesis fixation using PMMA bone cements has a market of about $200 million...
  12. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2004
    ..Specific Aims: 1 To formulate sub-cement, which will be similar to conventional PMMA bone cements in terms of modulus, yield stress, and viscosity but will be substantially more susceptible to fatigue crack ..
  13. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2005
    ..Specific Aims: 1 To formulate sub-cement, which will be similar to conventional PMMA bone cements in terms of modulus, yield stress, and viscosity but will be substantially more susceptible to fatigue crack ..
  14. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
    ....
  15. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2006
    ..Specific Aims: 1 To formulate sub-cement, which will be similar to conventional PMMA bone cements in terms of modulus, yield stress, and viscosity but will be substantially more susceptible to fatigue crack ..
  16. Fatigue Damage Evolution in Total Joint Replacements
    Kenneth Mann; Fiscal Year: 2008
    ....
  17. INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS
    Kenneth Mann; Fiscal Year: 2004
    ..When combined, the experimental and computational approaches will provide design guidelines that could significantly reduce revision rates of cemented hip replacements due to implant loosening. ..
  18. Fatigue Damage Evolution in Total Joint Replacements
    Kenneth Mann; Fiscal Year: 2007
    ....
  19. Fatigue Damage Evolution in Total Joint Replacements
    Kenneth Mann; Fiscal Year: 2009
    ....
  20. Fatigue Damage Evolution in Total Joint Replacements
    Kenneth Mann; Fiscal Year: 2006
    ....
  21. INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS
    Kenneth Mann; Fiscal Year: 2001
    ..When combined, the experimental and computational approaches will provide design guidelines that could significantly reduce revision rates of cemented hip replacements due to implant loosening. ..
  22. INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS
    Kenneth Mann; Fiscal Year: 2002
    ..When combined, the experimental and computational approaches will provide design guidelines that could significantly reduce revision rates of cemented hip replacements due to implant loosening. ..
  23. Fatigue Damage Evolution in Total Joint Replacements
    Kenneth A Mann; Fiscal Year: 2010
    ....
  24. INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS
    Kenneth Mann; Fiscal Year: 2003
    ..When combined, the experimental and computational approaches will provide design guidelines that could significantly reduce revision rates of cemented hip replacements due to implant loosening. ..
  25. Development of high performance, caries-inhibiting dental nano-materials
    HUAKUN XU; Fiscal Year: 2010
    ....
  26. 3D real time studying fatigue microcrack formation in cemented femur construct
    Gang Qi; Fiscal Year: 2007
    ..Type I microcracks directly contribute to the loosening of a femur stem constructs. Type II microcracks function as energy absorbers and thereby retard the loosening process. [unreadable] [unreadable] [unreadable]..
  27. DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS
    HUAKUN XU; Fiscal Year: 2007
    ..abstract_text> ..
  28. Development of high performance, caries-inhibiting dental nano-materials
    HUAKUN XU; Fiscal Year: 2009
    ....
  29. Development of high performance, caries-inhibiting dental nano-materials
    HUAKUN XU; Fiscal Year: 2008
    ....
  30. DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS
    HUAKUN XU; Fiscal Year: 2007
    ..abstract_text> ..
  31. Injectable and Strong Nano-Apatite/Stem Cell Scaffolds for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2009
    ....
  32. CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINS
    HUAKUN XU; Fiscal Year: 2002
    ....
  33. DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS
    HUAKUN XU; Fiscal Year: 2005
    ..abstract_text> ..
  34. DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS
    HUAKUN XU; Fiscal Year: 2003
    ..abstract_text> ..
  35. DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS
    HUAKUN XU; Fiscal Year: 2006
    ..abstract_text> ..
  36. DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS
    HUAKUN XU; Fiscal Year: 2004
    ..abstract_text> ..
  37. Rabbit Model for In Vivo Monitoring of Bone Structure
    Michael Voor; Fiscal Year: 2003
    ..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
  38. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..abstract_text> ..
  39. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2004
    ....
  40. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2002
    ..abstract_text> ..
  41. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    Bruce Frankel; Fiscal Year: 2009
    ..This has also been the basis for successful application and granting of Orphan-Drug designation for cytarabine (Ara-C) liposome injection (trade name: DepoCyt) for the treatment of gliomas. ..
  42. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2003
    ..abstract_text> ..
  43. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2009
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  44. Improved Animal Modeling of Saccular Aneurysms
    David F Kallmes; Fiscal Year: 2010
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  45. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2003
    ..abstract_text> ..
  46. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2003
    ....
  47. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart B Goodman; Fiscal Year: 2010
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  48. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    ..This has also been the basis for successful application and granting of Orphan-Drug designation for cytarabine (Ara-C) liposome injection (trade name: DepoCyt) for the treatment of gliomas. ..
  49. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
  50. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2007
    ..abstract_text> ..
  51. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2007
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  52. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2006
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  53. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  54. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2005
    ..abstract_text> ..
  55. Regulation of Cranial Suture Development by TGF-B and FG
    Arun Gosain; Fiscal Year: 2006
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  56. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2007
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  57. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  58. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2004
    ..abstract_text> ..
  59. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2008
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  60. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  61. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2008
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  62. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2008
    ..abstract_text> ..
  63. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2002
    ..abstract_text> ..
  64. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  65. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva Kotha; Fiscal Year: 2008
    ..Therefore, this research is important in building an insightful foundation for regulation of bone mass by mechanical loading and in evaluating molecular pathways to reduce fracture risk. ..
  66. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva Kotha; Fiscal Year: 2009
    ..Therefore, this research is important in building an insightful foundation for regulation of bone mass by mechanical loading and in evaluating molecular pathways to reduce fracture risk. ..
  67. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva Kotha; Fiscal Year: 2008
    ..Therefore, this research is important in building an insightful foundation for regulation of bone mass by mechanical loading and in evaluating molecular pathways to reduce fracture risk. ..