cxc chemokines

Summary

Summary: Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.

Top Publications

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  2. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
  3. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
  4. ncbi The role of CXC chemokines and their receptors in cancer
    Jo Vandercappellen
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cancer Lett 267:226-44. 2008
  5. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
  6. ncbi CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
  7. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  8. pmc A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    Jennifer M Burns
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    J Exp Med 203:2201-13. 2006
  9. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
  10. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003

Research Grants

  1. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
  2. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
  3. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
  4. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2009
  5. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    DEAN YAMAGUCHI; Fiscal Year: 2009
  6. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2004
  7. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2003
  8. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
  9. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2002
  10. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2001

Detail Information

Publications288 found, 100 shown here

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  2. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  3. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
    ..In CXCR4-negative cells expressing RDC1, CXCL12 promotes internalization of the receptor and chemotactic signals through RDC1. Collectively, our data indicate that RDC1, which we propose to rename as CXCR7, is a receptor for CXCL12...
  4. ncbi The role of CXC chemokines and their receptors in cancer
    Jo Vandercappellen
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cancer Lett 267:226-44. 2008
    ..In contrast, most of the CXC chemokines without ELR motif bind to CXCR3 and are angiostatic...
  5. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
  6. ncbi CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
    ..In this review, we focus on a role of the SDF-1-CXCR4 axis in regulating the metastatic behaviour of tumour cells and discuss the molecular mechanisms that are essential to this process...
  7. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  8. pmc A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    Jennifer M Burns
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    J Exp Med 203:2201-13. 2006
    ....
  9. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ....
  10. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
    ..Given the close relationship between hematopoietic stem cells and endothelial progenitor cells (EPCs), we investigated the effect of SDF-1 on EPC-mediated vasculogenesis...
  11. ncbi Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovasculariz
    Ken ichi Hiasa
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circulation 109:2454-61. 2004
    ..We therefore hypothesized that SDF-1alpha gene transfer would induce therapeutic neovascularization in vivo by functioning as a chemokine of EPC...
  12. pmc Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    L Izikson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1075-80. 2000
    ..These data indicate that CCR2 plays a necessary and nonredundant role in the pathogenesis of EAE...
  13. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
    ..We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy...
  14. ncbi Genetic content of wild-type human cytomegalovirus
    Aidan Dolan
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 85:1301-12. 2004
    ..The case in support of a lack of protein-coding potential in the region between UL105 and UL111A was also strengthened...
  15. doi Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx
    Richard A Dean
    Departments ofOral Biological and Medical Sciences, Centre for Blood Research, University of British Columbia, Vancouver, Canada
    Blood 112:3455-64. 2008
    ..MMP-12 specifically cleaves human ELR(+) CXC chemokines (CXCL1, -2, -3, -5, and -8) at E-LR, the critical receptor-binding motif or, for CXCL6, carboxyl-terminal to ..
  16. ncbi Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
    M Laan
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Goteborg University, Sweden
    J Immunol 162:2347-52. 1999
    ....
  17. ncbi Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Oral Biological and Medical Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 276:43503-8. 2001
    ..Here we report the N-terminal processing, also at position 4-5, of the CXC chemokines stromal cell-derived factor (SDF)-1alpha and beta by MMP-2 (gelatinase A)...
  18. ncbi The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    E Oberlin
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Nature 382:833-5. 1996
    ....
  19. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
  20. pmc The role of CXC chemokines in pulmonary fibrosis
    Robert M Strieter
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Clin Invest 117:549-56. 2007
    ..These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders...
  21. ncbi Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
    ..Migration occurred with an optimum dose similar to that found for adult hematopoietic cells and was dependent on the presence of SDF-1 in a gradient. This work suggests roles for chemokine signaling in multiple embryogenic events...
  22. ncbi Follicular stromal cells and lymphocyte homing to follicles
    J G Cyster
    Department of Microbiology and Immunology, University of California San Francisco, 94143 0414, USA
    Immunol Rev 176:181-93. 2000
    ..Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles...
  23. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
    ..The mature protein shares 23-34% identical amino acids with known CXC chemokines and is constitutively expressed in secondary lymphoid organs...
  24. ncbi The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, 90024, USA
    Am J Respir Crit Care Med 167:1676-86. 2003
    ..These data suggest that the CXCL12-CXCR4 biological axis is involved in regulating the metastasis of non-small cell lung cancer...
  25. ncbi Chemokine receptors
    R Horuk
    Department of Immunology, Berlex Bioscience, 15049 San Pablo Avenue, Richmond, CA 94804, USA
    Cytokine Growth Factor Rev 12:313-35. 2001
    ....
  26. ncbi Lymphoid neogenesis in rheumatoid synovitis
    S Takemura
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 167:1072-80. 2001
    ....
  27. ncbi The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    C C Bleul
    The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 382:829-33. 1996
    ....
  28. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...
  29. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone...
  30. pmc Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin
    T Nagasawa
    Department of Immunology, Osaka Medical Center for Maternal and Child Health, Japan
    Proc Natl Acad Sci U S A 93:14726-9. 1996
    ..Thus, PB-CKR will be an important tool for functional mapping of HIV-1 entry coreceptor fusin and for understanding the function of PBSF/SDF-1 further...
  31. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
  32. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  33. pmc Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
    Yan Zhu
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 5:719-20. 2002
    ....
  34. ncbi One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
    Thomas H Leung
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 118:453-64. 2004
    ..This suggests that binding sites may impart a specific configuration to bound transcription factors...
  35. ncbi CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5
    D Finke
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 17:363-73. 2002
    ..This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation...
  36. ncbi Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome
    N Amft
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Edgbaston, UK
    Arthritis Rheum 44:2633-41. 2001
    ....
  37. pmc IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain
    Richard J Bodnar
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261 0001, USA
    Circ Res 98:617-25. 2006
    ..This provides a means by which late wound repair signals limit the angiogenesis driven early in the wound response process...
  38. ncbi Synthesis of alpha-chemokines IP-10, I-TAC, and MIG are differentially regulated in human corneal keratocytes
    Karla A McInnis
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama, 307 University Boulevard, Mobile, AL 36688, USA
    Invest Ophthalmol Vis Sci 46:1668-74. 2005
    ..IP-10, I-TAC, and MIG are chemoattractants for these lymphocytes. The goal of this study was to determine whether human corneal keratocyte (HCKs) in culture synthesize these chemokines in response to proinflammatory mediators...
  39. ncbi CXC chemokines located in the 4q21 region are up-regulated in breast cancer
    Ivan Bieche
    INSERM, U844, Site Saint Eloi Bat INM, 80, rue Augustin Fliche, Montpellier F 34091, France
    Endocr Relat Cancer 14:1039-52. 2007
    ..Analysis of CXCL8 chromosomal location showed that several CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL4V1, CXCL5, CXCL6, CXCL7, and CXCL8) were localized in the same narrow region ..
  40. ncbi Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines
    J Krijgsveld
    Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:20374-81. 2000
    ..proteins using mass spectrometry and N-terminal sequencing revealed that TC-1 and TC-2 are variants of the CXC chemokines neutrophil-activating peptide-2 and connective tissue-activating peptide-III, respectively...
  41. ncbi Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1
    Ombretta Salvucci
    Experimental Transplantation and Immunology Branch and the Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2703-11. 2002
    ..These results indicate that SDF-1/CXCR-4 identifies VEGF- and bFGF-regulated autocrine signaling systems that are essential regulators of endothelial cell morphogenesis and angiogenesis...
  42. ncbi CXC chemokines in angiogenesis of cancer
    Robert M Strieter
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Semin Cancer Biol 14:195-200. 2004
    ..In this review we will appraise the biology of these angiogenic and angiostatic CXC chemokines, and discuss their disparate angiogenic activity in the context of the pathogenesis of cancer.
  43. ncbi Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4
    Agustin Valenzuela-Fernandez
    Unite d Immunologie Virale, INSERM U485 de l Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 277:15677-89. 2002
    ..Our findings suggest that elastase-mediated proteolysis of SDF-1/CXCR4 is part of a mechanism regulating their biological functions in both homeostatic and pathologic processes...
  44. ncbi Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes
    M B Delgado
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 31:699-707. 2001
    ..Owing to its availability on the surface of SDF-1-responsive cells and its rapid effect, cathepsin G is likely to play a significant role in down-regulating SDF-1 activity...
  45. pmc Chemokine requirements for B cell entry to lymph nodes and Peyer's patches
    Takaharu Okada
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 196:65-75. 2002
    ..These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches...
  46. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
    ..Furthermore, the central role of this chemokine in stem cell homing to the bone marrow as well as retention of undifferentiated cells within this tissue will also be discussed...
  47. ncbi Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Daniel J Ceradini
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Nat Med 10:858-64. 2004
    ..These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1...
  48. pmc CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:941-51. 2006
    ..Collectively, our findings show for the first time that CXCL1 is regulated by PGE2 and indicate that CXCL1 inhibitors should be evaluated further as potential anti-angiogenic agents for treatment of CRC...
  49. pmc DARC on RBC limits lung injury by balancing compartmental distribution of CXC chemokines
    Jörg Reutershan
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    Eur J Immunol 39:1597-607. 2009
    The Duffy antigen receptor for chemokines (DARC) has a high affinity for CC and CXC chemokines. However, it lacks the ability to induce cell responses that are typical for classical chemokine receptors...
  50. ncbi The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
    T Lapidot
    Dept of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Leukemia 16:1992-2003. 2002
    ..In particular, the essential roles of the chemokine SDF-1 and its receptor CXCR4 which mediate and regulate stem cell homing and repopulation will be discussed...
  51. ncbi Down-regulation of CXCL5 inhibits squamous carcinogenesis
    Hiroshi Miyazaki
    Philips Institute, Virginia Commonwealth University, Richmond, Virginia 23298 0566, USA
    Cancer Res 66:4279-84. 2006
    ....
  52. ncbi Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
    C Sgadari
    Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 87:3877-82. 1996
    ..These results document the important role of IP-10 as a mediator of angiogenesis inhibition by IL-12, and raise the possibility that IP-10 may also contribute to the antitumor effect of IL-12...
  53. ncbi Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
    ..In this study, the expression patterns of CXC chemokines (IL-8, ENA-78, GRO-alpha, I-TAC, Mig, and SDF-1) and their receptors (CXCR2, CXCR3, and CXCR4) were compared ..
  54. ncbi CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury
    Jeff N Vanderbilt
    Cardiovascular Research Institute Pediatrics, University of California San Francisco, Laurel Heights Campus, Suite 150, 3333 California Street, San Francisco, CA 94118, USA
    Am J Respir Cell Mol Biol 29:661-8. 2003
    The proinflammatory CXC chemokines GRO, CINC-2alpha, and macrophage inflammatory protein (MIP)-2 are a closely related family of neutrophil chemoattractants...
  55. ncbi Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Microcirculation 10:359-70. 2003
    ....
  56. ncbi Prostate carcinoma skeletal metastases: cross-talk between tumor and bone
    E T Keller
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, USA
    Cancer Metastasis Rev 20:333-49. 2001
    ..This review focuses on the interaction between the bone and the prostate carcinoma cells that allow for development and progression of prostate carcinoma skeletal metastases...
  57. ncbi Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    Peter Staller
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 425:307-11. 2003
    ....
  58. ncbi Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
    Eur J Immunol 33:3146-53. 2003
    ....
  59. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
    ..Thus, our results demonstrate, we believe for the first time, that circulating fibrocytes contribute to the pathogenesis of pulmonary fibrosis...
  60. ncbi Involvement of chemokine receptors in organ-specific metastasis
    Albert Zlotnik
    Department of Molecular Medicine, Neurocrine Biosciences, San Diego, Calif 92130, USA
    Contrib Microbiol 13:191-9. 2006
    ..The potential therapeutic importance of these observations depends on the role that each metastatic destination such as liver, lung, bone marrow, etc., plays in the prognosis of a cancer patient...
  61. ncbi Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    A Peled
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Science 283:845-8. 1999
    ..Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation...
  62. pmc SDF-1 is both necessary and sufficient to promote proliferative retinopathy
    Jason M Butler
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, Florida, USA
    J Clin Invest 115:86-93. 2005
    ..Together, these data demonstrate that SDF-1 plays a major role in proliferative retinopathy and may be an ideal target for the prevention of proliferative retinopathy...
  63. pmc Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines
    Kazutaka Hayashida
    Division of Respiratory Diseases, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 114:3033-43. 2009
    ..However, high levels of CXC chemokines (KC and MIP-2), particularly at later times after LPS, were specifically sustained in multiple organs in ..
  64. ncbi Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma
    Daisuke Uchida
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3 18 15 Kuramoto, Tokushima 770 8504, Japan
    Exp Cell Res 290:289-302. 2003
    ..These results indicate that SDF-1/CXCR4 signaling may be involved in the establishment of lymph node metastasis in oral SCC via activation of both ERK1/2 and Akt/PKB induced by SFKs...
  65. pmc Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
    K Honda
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 193:621-30. 2001
    ..Thus, promotion of PP development relies on mutual interaction between mesenchymal and lymphoid cells...
  66. ncbi Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
    Elwin J C Rombouts
    Department of Hematology, Room Ee1391, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Blood 104:550-7. 2004
    ..These data suggest that the SDF-1/CXCR-4 axis may influence therapy responsiveness and defines unfavorable prognosis in AML...
  67. ncbi Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
    G Herbein
    The Picower Institute for Medical Research, Manhasset, New York 11010, USA
    Nature 395:189-94. 1998
    ..These results indicate that the increased turnover of CD8+ T cells in HIV-infected subjects is mediated by the HIV envelope protein through the CXCR4 chemokine receptor...
  68. ncbi Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8
    Xuedong Fan
    Inflammation Department, Discovery Technologies Department, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 282:11658-66. 2007
    ..Similarly, CXC chemokines induce biological responses through the murine homolog of CXCR2, but the identification of functional rodent ..
  69. ncbi Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
    Victor Borrell
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Neurosci 9:1284-93. 2006
    ..Thus, the meningeal membranes are fundamental in the development of Cajal-Retzius cells and, hence, in the normal development of the cerebral cortex...
  70. ncbi Serum levels of ifn-inducible PROTEIN-10 relating to the activity of systemic lupus erythematosus
    S Narumi
    Department of Molecular Preventive Medicine, University of Tokyo, Tokyo, Japan
    Cytokine 12:1561-5. 2000
    ..These results suggest that serum IP-10 levels could be a good indicator for the activity of SLE and that IP-10 could play an important immunological role in SLE...
  71. ncbi The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor
    S K Ahuja
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:20545-50. 1996
    ..potent neutrophil chemoattractants 40-90% identical in amino acid sequence that comprise a subgroup of human CXC chemokines defined by the conserved sequence motif glutamic acid-leucine-arginine (ELR)...
  72. ncbi The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    P Loetscher
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Biol Chem 276:2986-91. 2001
    ..These results suggest that chemokines that attract Th1 cells via CXCR3 can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of T cell recruitment...
  73. ncbi Chemokines in human colorectal carcinoma
    P K Baier
    University of Freiburg, Department of Surgery, Freiburg, Germany
    Anticancer Res 25:3581-4. 2005
    ..The purpose of this study was to investigate whether CK expression is altered in colorectal carcinomas compared to normal mucosa and to elucidate its possible clinico-pathological implications...
  74. ncbi Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines
    A A Kocher
    Department of Surgery, Medicine, and Pathology, Columbia University, New York, USA
    J Mol Cell Cardiol 40:455-64. 2006
    ..Together, our results indicate that CXC chemokines play a central role in regulating vasculogenesis in the adult, and suggest that manipulation of interactions ..
  75. ncbi Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 169:424-33. 2002
    ....
  76. ncbi SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells
    Alma Zernecke
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circ Res 96:784-91. 2005
    ....
  77. pmc Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
    Satoko Matsumura
    Department of Pathology, New York University School of Medicine, New York, USA
    J Immunol 181:3099-107. 2008
    ..The ability of IR to convert tumors into "inflamed" peripheral tissues could be exploited to overcome obstacles at the effector phase of the antitumor immune response and improve the therapeutic efficacy of immunotherapy...
  78. pmc CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway
    Jianhua Wang
    Shanghai Jiao Tong University School of Medicine, Institute of Medical Sciences, Shanghai, PR China
    Cancer Res 68:10367-76. 2008
    ..Blocking the CXCR6/AKT/mTOR signaling pathway may prove beneficial to prevent metastasis and provide a more effective therapeutic strategy for PCa...
  79. ncbi Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow
    M Z Ratajczak
    Stem Cell Biology Program at James Graham Brown Cancer Center and Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Leukemia 18:29-40. 2004
    ....
  80. pmc Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection
    C Agostini
    Department of Clinical and Experimental Medicine, Padua University School of Medicine, Padua, Italy
    Am J Pathol 158:1703-11. 2001
    ....
  81. ncbi The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases
    Ingrid S Zeelenberg
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Res 63:3833-9. 2003
    ..Our results suggest that CXCR4 inhibitors have potential as anticancer agents to suppress outgrowth of micrometastases...
  82. ncbi Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease
    T E Lane
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 160:970-8. 1998
    ..These observations suggest a role for chemokines, notably CRG-2, in the initiation and maintenance of an inflammatory response following infection with MHV, which is important in contributing to demyelination...
  83. ncbi Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease
    Arantxa Apolinario
    Hepatology Unit, University Hospital Santa Cristina, Madrid, Spain
    Am J Gastroenterol 97:2861-70. 2002
    ..Although chemokines seem to be important in certain inflammatory disorders, little is known about the role of these proteins in chronic hepatitis C...
  84. pmc Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1
    Nicolas B David
    Groupe Danio, Institut National de la Santé et de la Recherche Médicale U368, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris, France
    Proc Natl Acad Sci U S A 99:16297-302. 2002
    ..We conclude that both the formation and the innervation of this system depend on the SDF1-CXCR4 system, which has also been implicated in several migration events in humans, including metastasis formation and lymphocyte homing...
  85. ncbi Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma
    S A Rempel
    Henry Ford Midwest Neuro Oncology Center, Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 6:102-11. 2000
    ....
  86. ncbi Expression of the chemokine IP-10 correlates with the accumulation of hepatic IFN-gamma and IL-18 mRNA in chronic hepatitis C but not in hepatitis B
    Sabine Mihm
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Georg August Universitat, Gottingen, Germany
    J Med Virol 70:562-70. 2003
    ..g., via its ability to activate IL-18 expressing cells and to initiate a delayed type hypersensitivity reaction...
  87. ncbi Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells
    Hui Peng
    Laboratory of Neurotoxicology, The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha 68198 5215, USA
    J Neurosci Res 76:35-50. 2004
    ..Ultimately, this study suggested that SDF-1alpha can influence NPC function through CXCR4 and that CXCR4 is functional on NPC...
  88. ncbi Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
    P L Shields
    Liver Research Laboratories and Department of Rheumatology, Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 163:6236-43. 1999
    ....
  89. ncbi Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism
    Jean Jacques Lataillade
    Laboratoire d Immunologie Cellulaire, centre de transfusion sanguine des armées Jean Julliard, Clamart Cedex, France
    Blood 99:1117-29. 2002
    ....
  90. ncbi Expression and regulation of chemokine receptors in human natural killer cells
    M Inngjerdingen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Blood 97:367-75. 2001
    ..Our results may have implications for the dissemination of NK cells at the sites of tumor growth or viral replication. (Blood. 2001;97:367-375)..
  91. ncbi VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    Myriam Grunewald
    Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell 124:175-89. 2006
    ..Together, the data suggest a model for VEGF-programmed adult neovascularization highlighting the essential paracrine role of recruited myeloid cells and a role for SDF1 in their perivascular retention...
  92. ncbi Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation
    Karla J Helbig
    Infectious Diseases Laboratories, Adelaide, Australia
    Hepatology 39:1220-9. 2004
    ....
  93. ncbi Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Lett 241:221-7. 2006
    A central feature of all solid tumor growth is the presence of neovascularization. The CXC chemokines GRO-gamma/CXCL3, ENA-78/CXCL5, and IL-8/CXCL8 have profound angiogenic potential mediated through the CXCR2 receptor...
  94. ncbi Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosis
    Shinobu Furuse
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Rheumatol 30:1524-8. 2003
    To determine whether serum concentrations of 2 CXC chemokines, interleukin 8 (IL-8) and growth-regulated oncogene-alpha (GRO-alpha), which are potent chemoattractants and activators for neutrophils, are elevated and whether they correlate ..
  95. ncbi CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma
    T Jinquan
    Laboratory of Medical Allergology, Allergy Unit, National University Hospital, University of Copenhagen, Copenhagen, Denmark
    J Immunol 165:1548-56. 2000
    ....
  96. pmc Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines
    Tanya A Miura
    Department of Microbiology, University of Colorado Health Sciences Center, MS 8333, PO Box 6511, Aurora, CO 80045, USA
    Virology 369:288-98. 2007
    ..SDAV and RCoV-P, and both live virus and UV-inactivated virus induced mRNA and protein expression of three CXC chemokines: CINC-2, CINC-3, and LIX, which are neutrophil chemoattractants...
  97. pmc ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis
    Kevin M O'Hayer
    Department of Pharmacology and Cancer Biology, DUMC, Durham, NC 27710, USA
    Carcinogenesis 30:1841-7. 2009
    ..two belong to the ELR+ Cys-X-Cys (CXC) chemokine family, we investigated whether the entire family of ELR+ CXC chemokines plays a role in oncogenic Ras-mediated tumorigenesis...
  98. pmc CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections
    Rachel M McLoughlin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10408-13. 2006
    ..Alphabeta T cell receptor (-/-) mice had significantly lower concentrations of PMN-specific CXC chemokines in wound tissue than did WT mice...
  99. ncbi Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner
    Bayasi Guleng
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Japan
    Cancer Res 65:5864-71. 2005
    ....
  100. ncbi Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells
    Julie M Hall
    Receptor Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:792-803. 2003
    ....
  101. doi Characterization of contraction-inducible CXC chemokines and their roles in C2C12 myocytes
    Taku Nedachi
    Center for Research Strategy and Support CRESS, Tohoku University, Sendai, Japan
    Am J Physiol Endocrinol Metab 297:E866-78. 2009
    ..In an effort to investigate the regulatory mechanisms of the expressions of two contraction-inducible CXC chemokines, CXCL1/KC and CXCL5/LIX, in contracting skeletal muscle cells, we took advantage of our in vitro exercise ..

Research Grants75

  1. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
    ..Underlying cellular and biochemical mechanisms will also be examined. This proposal may lead to a new nutraceutical treatment for COPD. ..
  2. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..Underlying cellular and biochemical mechanisms will also be examined. This proposal may lead to a new nutraceutical treatment for COPD. ..
  3. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
    ..Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric epithelial cells...
  4. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2009
    ..Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric epithelial cells...
  5. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    DEAN YAMAGUCHI; Fiscal Year: 2009
    ..A key step of bone repair occurs in the early inflammatory phase where there is an elaboration of CXC chemokines. CXC chemokines having a signature glu-leu-arg (ELR) sequence upstream to the CXC motif (ELR+ CXC chemokines) ..
  6. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2004
    ..In addition, CXC chemokines are responsible for extravasation into the parenchyma and are a key signal for the attack on individual ..
  7. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2003
    ..In addition, CXC chemokines are responsible for extravasation into the parenchyma and are a key signal for the attack on individual ..
  8. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
    ..In addition, CXC chemokines are responsible for extravasation into the parenchyma and are a key signal for the attack on individual ..
  9. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2002
    ..In addition, CXC chemokines are responsible for extravasation into the parenchyma and are a key signal for the attack on individual ..
  10. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2001
    ..In addition, CXC chemokines are responsible for extravasation into the parenchyma and are a key signal for the attack on individual ..
  11. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2004
    ..This capsule can activate CD4+ T cells and induce the production of CXC chemokines, peptides that activate and recruit PMNs to sites of inflammation...
  12. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..This capsule can activate CD4+ T cells and induce the production of CXC chemokines, peptides that activate and recruit PMNs to sites of inflammation...
  13. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2002
    ..This capsule can activate CD4+ T cells and induce the production of CXC chemokines, peptides that activate and recruit PMNs to sites of inflammation...
  14. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2003
    ..This capsule can activate CD4+ T cells and induce the production of CXC chemokines, peptides that activate and recruit PMNs to sites of inflammation...
  15. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2005
    ..This capsule can activate CD4+ T cells and induce the production of CXC chemokines, peptides that activate and recruit PMNs to sites of inflammation...
  16. Visualization of CXCR3 allelic usage in vivo
    Abhay R Satoskar; Fiscal Year: 2010
    ..The three main ligands of this receptor are the CXC chemokines CXCL9 (Mig), CXCL10 (IP-10) and CXCL11 (I-TAC), which are produced in high levels during inflammation...
  17. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2003
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  18. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2005
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  19. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2002
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  20. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2004
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  21. The Ron Receptor/Chemokine Axis in Prostate Cancer
    Susan Waltz; Fiscal Year: 2009
    ..Our preliminary data show that prostate cancer cell lines and tumors produce angiogenic CXC chemokines through a mechanism dependent on NF-:B activation...
  22. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 2000
    ..Finally, they will investigate whether the adverse effects of chemokines are enhanced by chronic ethanol consumption. ..
  23. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..in mice after chronic left pulmonary artery ligation (LPAL) where inflammatory cytokines, predominantly ELR+ CXC chemokines, appear to play a role in intercostal artery angiogenesis...
  24. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 1999
    ..Finally, they will investigate whether the adverse effects of chemokines are enhanced by chronic ethanol consumption. ..
  25. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2009
    ..laboratory has studied systemic angiogenesis in mice after chronic left pulmonary artery ligation where ELR+ CXC chemokines appear to play a role in intercostal artery angiogenesis...
  26. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2011
    ..laboratory has studied systemic angiogenesis in mice after chronic left pulmonary artery ligation where ELR+ CXC chemokines appear to play a role in intercostal artery angiogenesis...
  27. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2010
    ..laboratory has studied systemic angiogenesis in mice after chronic left pulmonary artery ligation where ELR+ CXC chemokines appear to play a role in intercostal artery angiogenesis...
  28. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2004
    ..Engagement of activating Fc-gammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  29. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2004
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  30. Exploration and development of antiangiogenic peptides for breast cancer
    Aleksander Popel; Fiscal Year: 2009
    ..in our laboratory derived from three classes of proteins: thrombospondin type I repeat-containing proteins;CXC chemokines;and alpha5 fibrils of collagen type IV...
  31. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2005
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  32. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2009
    ..Engagement of activating FcgammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  33. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2007
    ..Engagement of activating FcgammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  34. Exploration and development of antiangiogenic peptides for breast cancer
    Aleksander S Popel; Fiscal Year: 2010
    ..in our laboratory derived from three classes of proteins: thrombospondin type I repeat-containing proteins;CXC chemokines;and alpha5 fibrils of collagen type IV...
  35. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2005
    ..Engagement of activating FcgammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  36. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2006
    ..Engagement of activating FcgammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  37. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2003
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  38. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2010
    ..chemotactic activity of PGP may be due to a marked structural relatedness to a receptor binding domain of ELR+ CXC chemokines such as IL-8 which contain this collagen sequence or a close analog...
  39. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2005
    ..The results from our studies will fill in large gaps in our current knowledge and provide important new information as to the CNS pathobiology of the IFN-gamma-inducible non-ELR CXC chemokines.
  40. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2006
    ..The results from our studies will fill in large gaps in our current knowledge and provide important new information as to the CNS pathobiology of the IFN-gamma-inducible non-ELR CXC chemokines.
  41. Regulation of Chemokine Mediated Leukocyte Functions
    MICHELER RICHARDSON; Fiscal Year: 2009
    ..CXCR1 is specific for CXCL8 whereas CXCR2 binds six different CXC chemokines to activate leukocyte functions. Upon activation, CXCR2 scaffolds with several regulatory proteins (i.e...
  42. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2007
    ..The results from our studies will fill in large gaps in our current knowledge and provide important new information as to the CNS pathobiology of the IFN-gamma-inducible non-ELR CXC chemokines.
  43. Regulation of Chemokine Mediated Leukocyte Functions
    Micheler Ricardo Richardson; Fiscal Year: 2010
    ..CXCR1 is specific for CXCL8 whereas CXCR2 binds six different CXC chemokines to activate leukocyte functions. Upon activation, CXCR2 scaffolds with several regulatory proteins (i.e...
  44. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2004
    ..The results from our studies will fill in large gaps in our current knowledge and provide important new information as to the CNS pathobiology of the IFN-gamma-inducible non-ELR CXC chemokines.
  45. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2000
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  46. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 1999
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  47. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2002
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  48. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2001
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  49. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2006
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  50. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2002
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  51. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2007
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  52. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2005
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  53. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2003
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  54. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2004
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  55. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2001
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  56. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2004
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  57. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2005
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  58. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2003
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  59. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2002
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  60. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 1999
    ..dendritic cells and epidermal SLCs express selectin ligand-related sLeX epitopes (HECA-452), multiple CC and CXC chemokines receptors, LFA-1 and VLA4...
  61. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 2001
    ..dendritic cells and epidermal SLCs express selectin ligand-related sLeX epitopes (HECA-452), multiple CC and CXC chemokines receptors, LFA-1 and VLA4...
  62. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 2000
    ..dendritic cells and epidermal SLCs express selectin ligand-related sLeX epitopes (HECA-452), multiple CC and CXC chemokines receptors, LFA-1 and VLA4...
  63. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 2002
    ..dendritic cells and epidermal SLCs express selectin ligand-related sLeX epitopes (HECA-452), multiple CC and CXC chemokines receptors, LFA-1 and VLA4...
  64. CXC chemokines in pathogenesis of pulmonary fibrosis
    Peter Weller; Fiscal Year: 2001
    ..that promotes pulmonary fibrosis in IPF is due, in part, to angiogenesis, with over-expression of angiogenic CXC chemokines and downregulation of angiostatic interferon (IFN)-inducible CXC chemokines...
  65. CXC chemokines in pathogenesis of pulmonary fibrosis
    Peter Weller; Fiscal Year: 2002
    ..that promotes pulmonary fibrosis in IPF is due, in part, to angiogenesis, with over-expression of angiogenic CXC chemokines and downregulation of angiostatic interferon (IFN)-inducible CXC chemokines...
  66. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2000
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  67. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2004
    ..Our group recently found that production of two CXC chemokines, Interleukin-8 (IL-8) and Growth-Regulated Oncogene-alpha (GRO-alpha), is markedly stimulated following ..
  68. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2003
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  69. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2004
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  70. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2000
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  71. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2001
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  72. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2002
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  73. Bcl-2 and CXC Chemokines in Head and Neck Tumor Angioge*
    Jacques Nor; Fiscal Year: 2006
    ..endothelial cells that overexpress Bcl-2 become more angiogenic, and secrete high levels of the pro-angiogenic CXC chemokines interteukin (IL-8), and growth related oncogene GRO-alpha...
  74. Bcl-2 and CXC Chemokines in Head /Neck Tumor Angiogenesis /Metastasis
    Jacques Nor; Fiscal Year: 2007
    ..endothelial cells that overexpress Bcl-2 become more angiogenic, and secrete high levels of the pro-angiogenic CXC chemokines interteukin (IL-8), and growth related oncogene GRO-alpha...
  75. Rhinovirus and Airway Epithelial Cell Responses
    MARC HERSHENSON; Fiscal Year: 2007
    ..Understanding RV-induced asthma exacerbations will lead to improvements in the treatment of this disease. ..