cxc chemokines

Summary

Summary: Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.

Top Publications

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  2. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  3. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
  5. ncbi CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
  6. ncbi The role of CXC chemokines and their receptors in cancer
    Jo Vandercappellen
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cancer Lett 267:226-44. 2008
  7. pmc A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
    C C Bleul
    The Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA
    J Exp Med 184:1101-9. 1996
  8. ncbi The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    K Tachibana
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Japan
    Nature 393:591-4. 1998
  9. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
  10. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000

Detail Information

Publications314 found, 100 shown here

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  2. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  3. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
    ..In CXCR4-negative cells expressing RDC1, CXCL12 promotes internalization of the receptor and chemotactic signals through RDC1. Collectively, our data indicate that RDC1, which we propose to rename as CXCR7, is a receptor for CXCL12...
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  5. ncbi CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
    ..In this review, we focus on a role of the SDF-1-CXCR4 axis in regulating the metastatic behaviour of tumour cells and discuss the molecular mechanisms that are essential to this process...
  6. ncbi The role of CXC chemokines and their receptors in cancer
    Jo Vandercappellen
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Cancer Lett 267:226-44. 2008
    ..In contrast, most of the CXC chemokines without ELR motif bind to CXCR3 and are angiostatic...
  7. pmc A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
    C C Bleul
    The Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA
    J Exp Med 184:1101-9. 1996
    ..Since SDF-1 is expressed constitutively in a broad range of tissues it may have a role in immune surveillance and in basal extravasation of lymphocytes and monocytes rather than in inflammation...
  8. ncbi The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    K Tachibana
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Japan
    Nature 393:591-4. 1998
    ..We conclude that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization...
  9. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
    ..Given the close relationship between hematopoietic stem cells and endothelial progenitor cells (EPCs), we investigated the effect of SDF-1 on EPC-mediated vasculogenesis...
  10. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
  11. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  12. ncbi A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
    M Matloubian
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Nat Immunol 1:298-304. 2000
    ..CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking...
  13. ncbi Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovasculariz
    Ken ichi Hiasa
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circulation 109:2454-61. 2004
    ..We therefore hypothesized that SDF-1alpha gene transfer would induce therapeutic neovascularization in vivo by functioning as a chemokine of EPC...
  14. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ....
  15. pmc A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    Jennifer M Burns
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    J Exp Med 203:2201-13. 2006
    ....
  16. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
  17. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
  18. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
    ..We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy...
  19. ncbi Genetic content of wild-type human cytomegalovirus
    Aidan Dolan
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 85:1301-12. 2004
    ..The case in support of a lack of protein-coding potential in the region between UL105 and UL111A was also strengthened...
  20. ncbi Guidance of primordial germ cell migration by the chemokine SDF-1
    Maria Doitsidou
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    Cell 111:647-59. 2002
    ..Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs...
  21. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    ....
  22. ncbi Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Oral Biological and Medical Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 276:43503-8. 2001
    ..Here we report the N-terminal processing, also at position 4-5, of the CXC chemokines stromal cell-derived factor (SDF)-1alpha and beta by MMP-2 (gelatinase A)...
  23. ncbi Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
    M Laan
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Goteborg University, Sweden
    J Immunol 162:2347-52. 1999
    ....
  24. ncbi The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, 90024, USA
    Am J Respir Crit Care Med 167:1676-86. 2003
    ..These data suggest that the CXCL12-CXCR4 biological axis is involved in regulating the metastasis of non-small cell lung cancer...
  25. ncbi A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor
    Holger Knaut
    Max Planck Institut fur Entwicklungsbiologie, Abteilung III Genetik, Spemannstrasse 35, 72076 Tubingen, Germany
    Nature 421:279-82. 2003
    ....
  26. pmc Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    L Izikson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1075-80. 2000
    ..These data indicate that CCR2 plays a necessary and nonredundant role in the pathogenesis of EAE...
  27. pmc Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
    Masahiro Kato
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Breast Cancer Res 5:R144-50. 2003
    ..Recent studies have suggested that CXCR4 is expressed in certain cancer cells and that they use this chemokine receptor efficiently for metastasis formation...
  28. ncbi The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    E Oberlin
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Nature 382:833-5. 1996
    ....
  29. pmc An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
    Laura Lasagni
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Exp Med 197:1537-49. 2003
    ..monoclonal antibodies raised to selectively recognize CXCR3-B reacted with endothelial cells from neoplastic tissues, providing evidence that CXCR3-B is also expressed in vivo and may account for the angiostatic effects of CXC chemokines.
  30. pmc The role of CXC chemokines in pulmonary fibrosis
    Robert M Strieter
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Clin Invest 117:549-56. 2007
    ..These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders...
  31. ncbi Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
    ..Migration occurred with an optimum dose similar to that found for adult hematopoietic cells and was dependent on the presence of SDF-1 in a gradient. This work suggests roles for chemokine signaling in multiple embryogenic events...
  32. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
    ..The mature protein shares 23-34% identical amino acids with known CXC chemokines and is constitutively expressed in secondary lymphoid organs...
  33. ncbi Follicular stromal cells and lymphocyte homing to follicles
    J G Cyster
    Department of Microbiology and Immunology, University of California San Francisco, 94143 0414, USA
    Immunol Rev 176:181-93. 2000
    ..Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles...
  34. ncbi Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
    M Shirozu
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Genomics 28:495-500. 1995
    ..Strong evolutionary conservation and unique chromosomal localization of the SDF1 gene suggest that SDF1 alpha and SDF1 beta may have important functions distinct from those of other members of the intercrine family...
  35. pmc Chemokine requirements for B cell entry to lymph nodes and Peyer's patches
    Takaharu Okada
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 196:65-75. 2002
    ..These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches...
  36. pmc Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha
    R Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick Cancer Research and Development Center, Frederick, MD 21702 1202, USA
    Am J Pathol 154:1125-35. 1999
    ..Taken together, our data indicate that SDF-1alpha acts as a potent chemoattractant for endothelial cells of different origins bearing CXCR4 and is a participant in angiogenesis that is regulated at the receptor level by VEGF and bFGF...
  37. ncbi CXC chemokines located in the 4q21 region are up-regulated in breast cancer
    Ivan Bieche
    INSERM, U844, Site Saint Eloi Bat INM, 80, rue Augustin Fliche, Montpellier F 34091, France
    Endocr Relat Cancer 14:1039-52. 2007
    ..Analysis of CXCL8 chromosomal location showed that several CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL4V1, CXCL5, CXCL6, CXCL7, and CXCL8) were localized in the same narrow region ..
  38. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  39. ncbi The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity
    C L Addison
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:5269-77. 2000
    ..the receptor on endothelial cells responsible for chemotaxis and neovascularization mediated by these ELR(+) CXC chemokines has not been determined...
  40. ncbi Lymphoid neogenesis in rheumatoid synovitis
    S Takemura
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 167:1072-80. 2001
    ....
  41. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...
  42. ncbi Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells
    Julie M Hall
    Receptor Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:792-803. 2003
    ....
  43. ncbi Chemokine receptors
    R Horuk
    Department of Immunology, Berlex Bioscience, 15049 San Pablo Avenue, Richmond, CA 94804, USA
    Cytokine Growth Factor Rev 12:313-35. 2001
    ....
  44. ncbi Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
    K Hattori
    James Ewing Laboratory of Developmental Hematopoiesis, Sloan-Kettering Institute for Cancer Research, 1275 York Ave, New York, NY 10021, USA
    Blood 97:3354-60. 2001
    ..These studies lay the foundation for using SDF1 to induce mobilization of hematopoietic stem and progenitor cells in in vivo studies. (Blood. 2001;97:3354-3360)..
  45. ncbi Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx
    Richard A Dean
    Departments ofOral Biological and Medical Sciences, Centre for Blood Research, University of British Columbia, Vancouver, Canada
    Blood 112:3455-64. 2008
    ..MMP-12 specifically cleaves human ELR(+) CXC chemokines (CXCL1, -2, -3, -5, and -8) at E-LR, the critical receptor-binding motif or, for CXCL6, carboxyl-terminal to ..
  46. ncbi Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines
    A Wilbanks
    Millennium Pharmaceuticals, Cambridge, MA 02139, USA
    J Immunol 166:5145-54. 2001
    ..Additionally, this chemokine might play a unique dual role of attracting activated lymphocyte subsets during inflammation as well as facilitating immune responses via cell-cell contact...
  47. ncbi Mig and IP-10: CXC chemokines that target lymphocytes
    J M Farber
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 61:246-57. 1997
    ..Studies using recombinant (r) human proteins show that, unlike most other CXC chemokines, rHuMig and rIP-10 have no activity on neutrophils but appear to target lymphocytes specifically...
  48. ncbi The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    C C Bleul
    The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 382:829-33. 1996
    ....
  49. pmc Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin
    T Nagasawa
    Department of Immunology, Osaka Medical Center for Maternal and Child Health, Japan
    Proc Natl Acad Sci U S A 93:14726-9. 1996
    ..Thus, PB-CKR will be an important tool for functional mapping of HIV-1 entry coreceptor fusin and for understanding the function of PBSF/SDF-1 further...
  50. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone...
  51. pmc Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
    Yan Zhu
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 5:719-20. 2002
    ....
  52. ncbi Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
    C Sgadari
    Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 87:3877-82. 1996
    ..These results document the important role of IP-10 as a mediator of angiogenesis inhibition by IL-12, and raise the possibility that IP-10 may also contribute to the antitumor effect of IL-12...
  53. ncbi Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells
    Patrick Küry
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University of Dusseldorf, D 40225 Dusseldorf, Germany
    J Neurosci 22:7586-95. 2002
    ..In addition, we provide strong evidence that Mash2 is a negative regulator of Schwann cell proliferation. Mash2 represents a first candidate for the missing class B bHLH proteins in peripheral nerves...
  54. ncbi C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion
    Joshua M Thurman
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 178:1819-28. 2007
    ..This innate immune system thereby recognizes hypoxic injury and triggers a systemic inflammatory response through the generation of C3a and subsequent activation of the NF-kappaB system...
  55. pmc CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway
    Jianhua Wang
    Shanghai Jiao Tong University School of Medicine, Institute of Medical Sciences, Shanghai, PR China
    Cancer Res 68:10367-76. 2008
    ..Blocking the CXCR6/AKT/mTOR signaling pathway may prove beneficial to prevent metastasis and provide a more effective therapeutic strategy for PCa...
  56. ncbi The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1
    Koichi Hattori
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, Room D601 New York, NY 10021, USA
    Leuk Lymphoma 44:575-82. 2003
    ..These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting...
  57. ncbi Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes
    Mark S Segal
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0267, USA
    Diabetes 55:102-9. 2006
    ..This inability of diabetic EPCs to respond to SDF-1 may contribute to aberrant tissue vascularization and endothelial repair in diabetic patients...
  58. ncbi CXCL16 participates in pathogenesis of immunological liver injury by regulating T lymphocyte infiltration in liver tissue
    Huan Bin Xu
    Department of Immunology, Shanghai Medical College of Fudan University, Shanghai 200032, China
    World J Gastroenterol 11:4979-85. 2005
    ..To investigate the role of CXCL16 in the pathogenesis of immunological liver injury and to explore the possible mechanism of T lymphocyte infiltration regulated by CXCL16...
  59. ncbi Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    A Peled
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Science 283:845-8. 1999
    ..Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation...
  60. ncbi The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia
    S A Boehme
    Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
    J Immunol 165:397-403. 2000
    ..These results, therefore, suggest that the interaction between fractalkine and CX3CR-1 may play an important role in promoting and preserving microglial cell survival in the CNS...
  61. pmc Cytomegalovirus encodes a potent alpha chemokine
    M E Penfold
    Aviron, 297 Bernardo Avenue, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 96:9839-44. 1999
    ....
  62. ncbi Chemokine SDF-1 enhances circulating CD34(+) cell proliferation in synergy with cytokines: possible role in progenitor survival
    J J Lataillade
    Laboratoire d Immunologie Cellulaire, centre de transfusion sanguine des armées Jean Julliard, Clamart Cedex, France
    Blood 95:756-68. 2000
    ..Furthermore, both adhesion-induced CXCR-4 overexpression and SDF-1 stimulating activity may be of clinical relevance for improving cell therapy settings in stem cell transplantation...
  63. ncbi Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease
    Arantxa Apolinario
    Hepatology Unit, University Hospital Santa Cristina, Madrid, Spain
    Am J Gastroenterol 97:2861-70. 2002
    ..Although chemokines seem to be important in certain inflammatory disorders, little is known about the role of these proteins in chronic hepatitis C...
  64. pmc MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine
    Y Ohtsuka
    Department of Adult and Paediatric Gastroenterology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Gut 49:526-33. 2001
    ..We hypothesised that the production of MIP-2 by epithelial cells would increase leucocyte migration into the intestine...
  65. ncbi CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5
    D Finke
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 17:363-73. 2002
    ..This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation...
  66. ncbi CXC chemokines in angiogenesis of cancer
    Robert M Strieter
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Semin Cancer Biol 14:195-200. 2004
    ..In this review we will appraise the biology of these angiogenic and angiostatic CXC chemokines, and discuss their disparate angiogenic activity in the context of the pathogenesis of cancer.
  67. ncbi Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome
    N Amft
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Edgbaston, UK
    Arthritis Rheum 44:2633-41. 2001
    ....
  68. ncbi Synthesis of alpha-chemokines IP-10, I-TAC, and MIG are differentially regulated in human corneal keratocytes
    Karla A McInnis
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama, 307 University Boulevard, Mobile, AL 36688, USA
    Invest Ophthalmol Vis Sci 46:1668-74. 2005
    ..IP-10, I-TAC, and MIG are chemoattractants for these lymphocytes. The goal of this study was to determine whether human corneal keratocyte (HCKs) in culture synthesize these chemokines in response to proinflammatory mediators...
  69. ncbi Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines
    J Krijgsveld
    Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:20374-81. 2000
    ..proteins using mass spectrometry and N-terminal sequencing revealed that TC-1 and TC-2 are variants of the CXC chemokines neutrophil-activating peptide-2 and connective tissue-activating peptide-III, respectively...
  70. pmc IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain
    Richard J Bodnar
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261 0001, USA
    Circ Res 98:617-25. 2006
    ..This provides a means by which late wound repair signals limit the angiogenesis driven early in the wound response process...
  71. ncbi Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4
    Agustin Valenzuela-Fernandez
    Unite d Immunologie Virale, INSERM U485 de l Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 277:15677-89. 2002
    ..Our findings suggest that elastase-mediated proteolysis of SDF-1/CXCR4 is part of a mechanism regulating their biological functions in both homeostatic and pathologic processes...
  72. ncbi One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
    Thomas H Leung
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 118:453-64. 2004
    ..This suggests that binding sites may impart a specific configuration to bound transcription factors...
  73. ncbi Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes
    M B Delgado
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 31:699-707. 2001
    ..Owing to its availability on the surface of SDF-1-responsive cells and its rapid effect, cathepsin G is likely to play a significant role in down-regulating SDF-1 activity...
  74. pmc CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:941-51. 2006
    ..Collectively, our findings show for the first time that CXCL1 is regulated by PGE2 and indicate that CXCL1 inhibitors should be evaluated further as potential anti-angiogenic agents for treatment of CRC...
  75. pmc DARC on RBC limits lung injury by balancing compartmental distribution of CXC chemokines
    Jörg Reutershan
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    Eur J Immunol 39:1597-607. 2009
    The Duffy antigen receptor for chemokines (DARC) has a high affinity for CC and CXC chemokines. However, it lacks the ability to induce cell responses that are typical for classical chemokine receptors...
  76. ncbi Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Daniel J Ceradini
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Nat Med 10:858-64. 2004
    ..These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1...
  77. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
    ..Furthermore, the central role of this chemokine in stem cell homing to the bone marrow as well as retention of undifferentiated cells within this tissue will also be discussed...
  78. ncbi Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism
    Jean Jacques Lataillade
    Laboratoire d Immunologie Cellulaire, centre de transfusion sanguine des armées Jean Julliard, Clamart Cedex, France
    Blood 99:1117-29. 2002
    ....
  79. pmc Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
    M Eck
    Institut fur Pathologie, Universitat Wurzburg, Germany
    Clin Exp Immunol 134:508-15. 2003
    b>CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours...
  80. ncbi Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1
    Ombretta Salvucci
    Experimental Transplantation and Immunology Branch and the Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2703-11. 2002
    ..These results indicate that SDF-1/CXCR-4 identifies VEGF- and bFGF-regulated autocrine signaling systems that are essential regulators of endothelial cell morphogenesis and angiogenesis...
  81. pmc The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers
    Merav Darash-Yahana
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    PLoS ONE 4:e6695. 2009
    ....
  82. pmc The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
    S Qin
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 101:746-54. 1998
    ..Moreover, CXCR3 and CCR5 appear to identify subsets of T cells in blood with a predilection for homing to these sites...
  83. ncbi Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines
    Peter Seiler
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Eur J Immunol 33:2676-86. 2003
    ..Hence, PMN play a central role in regulating the focal granulomatous response in the lung, and this early granuloma formation can be segregated from long-term protection against pulmonary M. tuberculosis infection...
  84. ncbi Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
    P L Shields
    Liver Research Laboratories and Department of Rheumatology, Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 163:6236-43. 1999
    ....
  85. pmc Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons
    Yoshiki Arakawa
    Dept of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8315, Japan
    J Cell Biol 161:381-91. 2003
    ..Furthermore, RNAi knockdown of mDia1 abolished SDF-1alpha-induced axon elongation. Together, our results support a critical role for an SDF-1alpha/Rho/mDia1 pathway in mediating axon elongation...
  86. ncbi The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
    T Lapidot
    Dept of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Leukemia 16:1992-2003. 2002
    ..In particular, the essential roles of the chemokine SDF-1 and its receptor CXCR4 which mediate and regulate stem cell homing and repopulation will be discussed...
  87. ncbi Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Microcirculation 10:359-70. 2003
    ....
  88. pmc SDF-1 is both necessary and sufficient to promote proliferative retinopathy
    Jason M Butler
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, Florida, USA
    J Clin Invest 115:86-93. 2005
    ..Together, these data demonstrate that SDF-1 plays a major role in proliferative retinopathy and may be an ideal target for the prevention of proliferative retinopathy...
  89. ncbi CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury
    Jeff N Vanderbilt
    Cardiovascular Research Institute Pediatrics, University of California San Francisco, Laurel Heights Campus, Suite 150, 3333 California Street, San Francisco, CA 94118, USA
    Am J Respir Cell Mol Biol 29:661-8. 2003
    The proinflammatory CXC chemokines GRO, CINC-2alpha, and macrophage inflammatory protein (MIP)-2 are a closely related family of neutrophil chemoattractants...
  90. ncbi Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    Peter Staller
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 425:307-11. 2003
    ....
  91. pmc Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines
    Kazutaka Hayashida
    Division of Respiratory Diseases, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 114:3033-43. 2009
    ..However, high levels of CXC chemokines (KC and MIP-2), particularly at later times after LPS, were specifically sustained in multiple organs in ..
  92. ncbi Down-regulation of CXCL5 inhibits squamous carcinogenesis
    Hiroshi Miyazaki
    Philips Institute, Virginia Commonwealth University, Richmond, Virginia 23298 0566, USA
    Cancer Res 66:4279-84. 2006
    ....
  93. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
    ..Thus, our results demonstrate, we believe for the first time, that circulating fibrocytes contribute to the pathogenesis of pulmonary fibrosis...
  94. ncbi Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
    ..In this study, the expression patterns of CXC chemokines (IL-8, ENA-78, GRO-alpha, I-TAC, Mig, and SDF-1) and their receptors (CXCR2, CXCR3, and CXCR4) were compared ..
  95. ncbi Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
    Eur J Immunol 33:3146-53. 2003
    ....
  96. ncbi Prostate carcinoma skeletal metastases: cross-talk between tumor and bone
    E T Keller
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, USA
    Cancer Metastasis Rev 20:333-49. 2001
    ..This review focuses on the interaction between the bone and the prostate carcinoma cells that allow for development and progression of prostate carcinoma skeletal metastases...
  97. ncbi The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    P Loetscher
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Biol Chem 276:2986-91. 2001
    ..These results suggest that chemokines that attract Th1 cells via CXCR3 can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of T cell recruitment...
  98. ncbi Serum levels of ifn-inducible PROTEIN-10 relating to the activity of systemic lupus erythematosus
    S Narumi
    Department of Molecular Preventive Medicine, University of Tokyo, Tokyo, Japan
    Cytokine 12:1561-5. 2000
    ..These results suggest that serum IP-10 levels could be a good indicator for the activity of SLE and that IP-10 could play an important immunological role in SLE...
  99. ncbi Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
    G Herbein
    The Picower Institute for Medical Research, Manhasset, New York 11010, USA
    Nature 395:189-94. 1998
    ..These results indicate that the increased turnover of CD8+ T cells in HIV-infected subjects is mediated by the HIV envelope protein through the CXCR4 chemokine receptor...
  100. ncbi Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
    Elwin J C Rombouts
    Department of Hematology, Room Ee1391, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Blood 104:550-7. 2004
    ..These data suggest that the SDF-1/CXCR-4 axis may influence therapy responsiveness and defines unfavorable prognosis in AML...
  101. ncbi Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma
    Daisuke Uchida
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3 18 15 Kuramoto, Tokushima 770 8504, Japan
    Exp Cell Res 290:289-302. 2003
    ..These results indicate that SDF-1/CXCR4 signaling may be involved in the establishment of lymph node metastasis in oral SCC via activation of both ERK1/2 and Akt/PKB induced by SFKs...

Research Grants63

  1. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric epithelial cells...
  2. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2013
    ..chemotactic activity of PGP may be due to a marked structural relatedness to a receptor binding domain of ELR+ CXC chemokines such as IL-8 which contain this collagen sequence or a close analog...
  3. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..A critical step of bone repair occurs in the early inflammatory phase where there is an elaboration of CXC chemokines. CXC chemokines have a signature glu-leu-arg (ELR) sequence upstream to the CXC motif (ELR+ CXC chemokines) ..
  4. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2012
    ..laboratory has studied systemic angiogenesis in mice after chronic left pulmonary artery ligation where ELR+ CXC chemokines appear to play a role in intercostal artery angiogenesis...
  5. A novel proteolytic system of pulmonary inflammation
    Amit Gaggar; Fiscal Year: 2013
    ..the airways of mice;this cellular specificity is due to structural relatedness to a receptor binding domain of CXC chemokines such as IL-8...
  6. Inflammatory and Chemotactic Cytokines in Bronchopulmonary Dysplasia
    Vedang A Londhe; Fiscal Year: 2011
    ..in a mouse model mimicking viral lung infection, double stranded RNA (dsRNA) activates NF-kB and induces CXC chemokines KC(CXCL1) and MIP-2(CXCL2/3) to recruit neutrophils expressing CXCR2 leading to inflammation...
  7. Host Interactions of Salmonella typhimurium
    Charles L Bevins; Fiscal Year: 2013
    ..drives a two-pronged innate immune response by inducing expression in the intestinal epithelium of both CXC chemokines and defensins...
  8. Chemokine regulation of liver injury and recovery
    Alex B Lentsch; Fiscal Year: 2013
    ..In models of hepatectomy, it has been shown that these same CXC chemokines directly stimulate hepatocytes to proliferate, thereby promoting liver regeneration...
  9. Controlling Bacterial Biofilms in Cystic Fibrosis Airways
    GERARD C WONG; Fiscal Year: 2010
    ..PMN chemotactic activity of PGP may be due to a marked structural relatedness to a receptor binding domain of CXC chemokines such as IL-8 which contain this collagen sequence or a close analog...
  10. Therapeutics for Chronic Lung Diseases: Antagonists of PGP, Chemokines and CXCR
    J Edwin Blalock; Fiscal Year: 2010
    ..PMN chemotactic activity of PGP may be due to a marked structural relatedness to a receptor binding domain of CXC chemokines such as IL-8 which contain this collagen sequence or a close analog...
  11. IL-23: Actions and Regulation in Pseudomonas aeruginosa Pulmonary Infection
    Patricia J Dubin; Fiscal Year: 2011
    ..aeruginosa infection and that this results in elevated IL-17, CXC chemokines and a neutrophilic response...
  12. Chemokine Compartmentalization and Neutrophil Accumulation in the Lung
    George Scott Worthen; Fiscal Year: 2013
    ..to microorganisms by activating inflammatory mechanisms that attract neutrophils, dependent in part on ELR+ CXC chemokines, whose localization within specific compartments (plasma, erythrocyte, airspace, endothelium among others) ..
  13. Bacillus anthracis Targets Involved in Chemokine-Mediated Antimicrobial Activity
    Molly A Hughes; Fiscal Year: 2013
    ..We previously reported that the interferon-inducible CXC chemokines, CXCL9, CXCL10, and CXCL11, block Bacillus anthracis spore germination, reduce spore viability, and kill ..
  14. The Ron Receptor/Chemokine Axis in Prostate Cancer
    Susan E Waltz; Fiscal Year: 2012
    ..Our preliminary data show that prostate cancer cell lines and tumors produce angiogenic CXC chemokines through a mechanism dependent on NF-kB activation...
  15. NK cells in host defense against invasive aspergillosis
    Borna Mehrad; Fiscal Year: 2013
    ..that activation of NK cells and NK cell induction of the interferon-[unreadable]-inducible ELR-negative CXC chemokines are critical to host defense in invasive aspergillosis...
  16. CXC Chemokines and Regulation of Granulopoiesis
    George Scott Worthen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The chemokine receptor CXCR2 is the only receptor for ELR+ CXC chemokines in the mouse, deletion of which increases of neutrophils and progenitors in the marrow, as well as systemic expression of G-..
  17. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..This capsule can activate CD4+ T cells and induce the production of CXC chemokines, peptides that activate and recruit PMNs to sites of inflammation...
  18. CD8+ Th17 and Costimulation Blockade Resistant Allograft Rejection
    D Keith Bishop; Fiscal Year: 2010
    ..Specific Aim 2 will test the hypothesis that the Th17 effector cytokines IL-17 and IL-22 induce CXC chemokines and G-CSF within the graft, leading to the recruitment of the neutrophil rich infiltrate which is ..
  19. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 2000
    ..Finally, they will investigate whether the adverse effects of chemokines are enhanced by chronic ethanol consumption. ..
  20. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2009
    ..Engagement of activating FcgammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  21. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2004
    ..Engagement of activating Fc-gammaR and C5aR induces the release of the CXC chemokines KC and MIP- 2 by resident peritoneal mast cells and macrophages, which play an important role in neutrophil ..
  22. Exploration and development of antiangiogenic peptides for breast cancer
    Aleksander S Popel; Fiscal Year: 2010
    ..in our laboratory derived from three classes of proteins: thrombospondin type I repeat-containing proteins;CXC chemokines;and alpha5 fibrils of collagen type IV...
  23. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2005
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  24. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..in mice after chronic left pulmonary artery ligation (LPAL) where inflammatory cytokines, predominantly ELR+ CXC chemokines, appear to play a role in intercostal artery angiogenesis...
  25. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2007
    ..In Specific Aim 2, we will show that IL-17 enhances host release of CXC chemokines and recruitment of neutrophils in response to K. Pneumoniae...
  26. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2005
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  27. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2004
    ..proposal is that the influx of neutrophils into the lung in invasive pulmonary aspergillosis is mediated by CXC chemokines, and that manipulation of these ligands or their receptor will significantly impact the outcome of infection...
  28. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2004
    ..Our group recently found that production of two CXC chemokines, Interleukin-8 (IL-8) and Growth-Regulated Oncogene-alpha (GRO-alpha), is markedly stimulated following ..
  29. NEUTROPHILS AND STAPHYLOCOCCUS AUREUS
    Hattie Gresham; Fiscal Year: 2004
    ..aureus taken up both in vivo and in vitro by C-X-C chemokine-stimulated PMN. ..
  30. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2007
    ..The beneficial properties of CXC chemokines have not been fully characterized...
  31. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 1999
    ..dendritic cells and epidermal SLCs express selectin ligand-related sLeX epitopes (HECA-452), multiple CC and CXC chemokines receptors, LFA-1 and VLA4...
  32. Role of CXC chemokines at the innate-adaptive interface of alloimmune lung injury
    Tereza Martinu; Fiscal Year: 2007
    ..Recent data suggest that CXC chemokines, interacting with the CXC receptor 3 (CXCR3), play an important role in recruiting T-cells to sites of innate ..
  33. ELR+ CXC CHEMOKINES IN PSEUDOMONAS AIRWAY INFECTION
    WAN TSAI; Fiscal Year: 2004
    ..the influx of neutrophils into the airways in chronic Pseudomonas endobronchial infection is mediated by ELR+CXC chemokines, and that manipulation of these ligands or their receptor will impact the outcome of infection in airways of ..
  34. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2009
    ..A mechanistic understanding of the interactions between HIV and these C-X-C chemokines could lead to the development of new approaches to the treatment of patients infected with HIV. ..
  35. CARDIOMYOPATHY, HIV1 AND CHEMOKINES
    Milan Fiala; Fiscal Year: 2001
    ..The results of this research could lead to development of new strategies for preventing or ameliorating the effects of HIV infection on the heart. ..
  36. REGULATION OF MATRIX-INDUCED GENES IN LUNG MACROPHAGES
    Maureen Horton; Fiscal Year: 2003
    ..These studies should allow the applicant to further enhance and develop her research skills and enable her to pursue the basic molecular mechanisms of pulmonary fibrosis that might lead to novel treatment approaches. ..
  37. INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALING
    Alan Wells; Fiscal Year: 2003
    ..During the first period of this grant we found that growth factors and ELR-CXC chemokines promoted or limited cell motility, respectively, by affecting cell-substratum adhesiveness, and that this was ..
  38. Bone Marrow Angioblasts For Cardiac Regeneration
    Silviu Itescu; Fiscal Year: 2004
    ..In the second aim, we will examine the role of specific CXC chemokines in angioblast migration to chronically ischemic myocardium...
  39. REGULATION OF EXPRESSION OF MGSA/GRO GENES IN MELANOMA
    Ann Richmond; Fiscal Year: 2001
    ..contribute to MGSA deregulation in melanoma; 3) to characterize the prevalence or coordinate deregulation of CXC chemokines in malignant melanoma; and 4) to determine whether overexpression of the mouse homolog of MGSA in normal ..
  40. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..derived angiogenesis is determined by an imbalance in the expression of angiogenic as compared to angiostatic CXC chemokines. Our preliminary data demonstrates that IL-8 is a common angiogenic CXC chemokine which is constitutively ..
  41. A Novel Inflammatory Signal in Pulmonary Neutrophilia
    Nathaniel Weathington; Fiscal Year: 2007
    ..PMN chemotactic activity of PGP may be due to a marked structural relatedness to a receptor binding domain of CXC chemokines specific for PMN such as IL-8, which contain this collagen sequence or a close analog...
  42. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  43. Development Expression of Chemokines and Their Receptors
    DARLENE CALHOUN; Fiscal Year: 2002
    ..Candidate chemokine/chemokine receptors for influencing neutrophil chemotaxis include members of the CXC chemokines. We propose that understanding the gene regulation for the expression of specific chemokine receptors (CXCR) ..
  44. Chemokine induced hematopoietic stem cell mobilization
    LOUIS PELUS; Fiscal Year: 2009
    ....
  45. Bcl-2 and CXC Chemokines in Head /Neck Tumor Angiogenesis /Metastasis
    Jacques Nor; Fiscal Year: 2008
    ..endothelial cells that overexpress Bcl-2 become more angiogenic, and secrete high levels of the pro-angiogenic CXC chemokines interteukin (IL-8), and growth related oncogene GRO-alpha...
  46. Role of Survivin in Blood Stem Cell Cycle and Apoptosis
    LOUIS PELUS; Fiscal Year: 2007
    ....
  47. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..We have recently described the temporal expression of three neutrophil chemoattractant CXC chemokines - LIX (lipopolysachharide-induced CXC chemokine), KC (cytokine-induced neutrophil chemoattractant) and MIP-2 (..
  48. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2008
    ..The results from our studies will fill in large gaps in our current knowledge and provide important new information as to the CNS pathobiology of the IFN-gamma-inducible non-ELR CXC chemokines.
  49. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  50. CHEMOKINES REGULATE ANGIOGENESIS IN PULMONARY FIBROSIS
    Michael Keane; Fiscal Year: 2003
    ..pathogenesis of ILD an imbalance exists in the presence of angiostatic (IP-10) and angiogenic (MIP-2, IL-8) CXC chemokines. This paradigm of biological imbalance will favor net angiogenesis supporting fibroplasia and deposition of ..
  51. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  52. Development of an animal model for autoimmune hepatitis
    Urs Christen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  54. Low Cost Production of the Malaria Drug Artemether
    Brooks Hybertson; Fiscal Year: 2007
    ..This project seeks to develop, validate, and commercialize a new, cheaper method for producing the highly effective malaria drug artemether from the Sweet Wormwood plant. [unreadable] [unreadable] [unreadable]..
  55. CHEMOKINE BIOLOGY IN BRONCHIOLITIS OBLITERANS SYNDROME
    John Belperio; Fiscal Year: 2005
    ..The understanding of this pathobiology will lead to novel therapies in the treatment and prevention of chronic lung allograft rejection, BOS. ..
  56. The Role of Chemokines During Lung Allograft Dysfunction
    John Belperio; Fiscal Year: 2009
    ..The aims in this proposal may lead to therapeutic targets for this biology and intervention to reduce the incidence of early (ischemiareperfusion injury) and late (BOS) lung allograft dysfunction. ..
  57. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2009
    ..Inflammatory mediators, such as the CXC chemokines, are essential for the liver's response to injury...
  58. HEPATIC ISCHEMIA/REPERFUSION-INDUCED LUNG INJURY
    ALEX LENTSCH; Fiscal Year: 2006
    ..The knowledge gained from these studies will provide mechanistic explanations for new therapeutic options for acute lung injury, and may be applicable to a number of other inflammatory lung diseases. ..
  59. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..These studies will help to elucidate novel mechanisms in SCF-mediated hepatocyte protection and regeneration in a clinically relevant liver resection and toxicity model. ..
  60. Systemic perinatal insults disrupt neurodevelopment
    Shenandoah Robinson; Fiscal Year: 2008
    ..Insights into mechanisms underlying the disruption of perinatal neural development will lead to novel interventions to enhance neural development in neonates, and minimize neurologic deficits. ..
  61. Chemokines and lymphocyte trafficking into the CNS
    Robyn Klein; Fiscal Year: 2007
    ..As evidenced by almost nine years of research in the neurosciences, the applicant remains firmly committed to a long-term career in basic science investigation. ..
  62. Immunomodulatory Effects of Mechanical Ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2007
    ....