chemokines

Summary

Summary: Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.

Top Publications

  1. ncbi Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  2. pmc Inflammation and cancer
    Lisa M Coussens
    Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
    Nature 420:860-7. 2002
  3. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
  4. ncbi The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  5. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
  6. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
  7. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
  8. doi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
  9. doi Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury
    Jenna M Ziebell
    National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, VIC 3181, Australia
    Neurotherapeutics 7:22-30. 2010
  10. ncbi A question of self-preservation: immunopathology in influenza virus infection
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 85:85-92. 2007

Detail Information

Publications343 found, 100 shown here

  1. ncbi Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  2. pmc Inflammation and cancer
    Lisa M Coussens
    Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
    Nature 420:860-7. 2002
    ..tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis...
  3. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  4. ncbi The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  5. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
    ..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
  6. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
  7. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  8. doi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    ..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
  9. doi Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury
    Jenna M Ziebell
    National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, VIC 3181, Australia
    Neurotherapeutics 7:22-30. 2010
    ..This review addresses the role of several cytokines and chemokines following focal and diffuse TBI, as well as the controversies around the use of therapeutic anti-inflammatory ..
  10. ncbi A question of self-preservation: immunopathology in influenza virus infection
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 85:85-92. 2007
    ....
  11. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
    ..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
  12. pmc Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks
    Bridgette D Semple
    National Trauma Research Institute, Alfred Health, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:459-73. 2010
    b>Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of particular interest in the context of the unique immune responses elicited in the central nervous system (CNS)...
  13. doi Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion
    Yukihiko Suzuki
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, Aomori, 036 8562, Japan
    Jpn J Ophthalmol 55:256-63. 2011
    The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO)...
  14. pmc Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology
    Richard M Ransohoff
    Neuroinflammation Research Center Lerner Research Institute and Mellen Center for MS Treatment and Research Neurological Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 31:711-21. 2009
    There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology...
  15. ncbi The role of chemokine receptors in primary, effector, and memory immune responses
    F Sallusto
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Annu Rev Immunol 18:593-620. 2000
    ..There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic ..
  16. ncbi Chemokines and disease
    C Gerard
    Department of Pediatrics, Perlmutter Laboratory, Children s Hospital, Boston, MA, USA
    Nat Immunol 2:108-15. 2001
    ..Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed...
  17. ncbi Chemokine receptors and their role in inflammation and infectious diseases
    C Murdoch
    Division of Child Health, University of Sheffield, Sheffield Children s Hospital, Sheffield, United Kingdom
    Blood 95:3032-43. 2000
    b>Chemokines are small peptides that are potent activators and chemoattractants for leukocyte subpopulations and some nonhemopoietic cells...
  18. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
    ..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
  19. ncbi The role of chemokines in neutrophil biology
    Yoshiro Kobayashi
    Division of Molecular Medicine, Dept of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan
    Front Biosci 13:2400-7. 2008
    ..Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment...
  20. pmc Chemokines and chemokine receptors: new insights into cancer-related inflammation
    Gwendal Lazennec
    INSERM, U844, Site Saint Eloi Bâtiment INM 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F 34090, France
    Trends Mol Med 16:133-44. 2010
    b>Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation...
  21. ncbi Chemokines in liver inflammation and fibrosis
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
    Semin Liver Dis 30:215-25. 2010
    b>Chemokines are a class of small chemotactic molecules with cytokine-like functions, which are well known to orchestrate inflammatory responses within different organs. Overall, more than 50 ligands and 19 receptors belong to the network...
  22. ncbi Chemokines and their receptors: drug targets in immunity and inflammation
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Annu Rev Pharmacol Toxicol 48:171-97. 2008
    ..Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics...
  23. doi Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis
    Heidi Kokkonen
    Umea University Hospital, Umea, Sweden
    Arthritis Rheum 62:383-91. 2010
    To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA).
  24. ncbi Orchestrating the orchestrators: chemokines in control of T cell traffic
    Shannon K Bromley
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:970-80. 2008
    The understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors have been identified...
  25. pmc Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids
    Valerie Wittamer
    Institut de Recherche en Biologie Humaine et Moléculaire, ULB Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    J Exp Med 198:977-85. 2003
    ..Therefore, chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs...
  26. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ..We show that the functional responses of freshly isolated human and murine neutrophils to CXCR2 chemokines are significantly attenuated by SDF-1alpha, acting via CXCR4...
  27. ncbi Chemerin is a novel adipokine associated with obesity and metabolic syndrome
    Kiymet Bozaoglu
    Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
    Endocrinology 148:4687-94. 2007
    ..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
  28. ncbi Chemokines in liver inflammation and fibrosis
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Italy
    Front Biosci 7:d1899-914. 2002
    b>Chemokines may be involved in the tissue response to injury regulating the influx of leukocytes, and modulating a number of other critical biologic actions, including angiogenesis, neoplastic growth, myo-fibroblast activation, and the ..
  29. ncbi Molecular pathways linking inflammation and cancer
    A Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Mol Med 10:369-73. 2010
    ..Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  30. ncbi Chemokine: receptor structure, interactions, and antagonism
    Samantha J Allen
    Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Immunol 25:787-820. 2007
    b>Chemokines are critical mediators of cell migration during routine immune surveillance, inflammation, and development...
  31. ncbi Cancer and the chemokine network
    Fran Balkwill
    Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s Medical School, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Cancer 4:540-50. 2004
  32. ncbi Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system
    William Rostene
    Institut de la Vision UMRS INSERM UPMC 968, Paris, France
    J Neurochem 118:680-94. 2011
    Recent observations suggest that besides their role in the immune system, chemokines have important functions in the brain...
  33. ncbi Chemokines: multiple levels of leukocyte migration control
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Trends Immunol 25:75-84. 2004
    The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to leukocyte traffic...
  34. ncbi Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    M Romano
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Immunity 6:315-25. 1997
    ..to a reduced migratory capacity of IL-6-/- leukocytes and was associated with a reduced in situ production of chemokines. These observations led to a reexamination of the interaction of IL-6 with endothelial cells (EC)...
  35. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  36. ncbi Characterization of chemokines and their receptors in the central nervous system: physiopathological implications
    Adriana Bajetto
    Service of Pharmacology and Neuroscience Institute for Cancer Research, Genoa, Italy
    J Neurochem 82:1311-29. 2002
    b>Chemokines represent key factors in the outburst of the immune response, by activating and directing the leukocyte traffic, both in lymphopoiesis and in immune surveillance...
  37. pmc Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    Mika Shimonaka
    Bayer Chair, Dept of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 161:417-27. 2003
    b>Chemokines arrest circulating lymphocytes within the vasculature through the rapid up-regulation of leukocyte integrin adhesive activity, promoting subsequent lymphocyte transmigration...
  38. ncbi Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
    Kerry B Goralski
    Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 282:28175-88. 2007
    ..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
  39. pmc The chemokine and chemokine receptor superfamilies and their molecular evolution
    Albert Zlotnik
    Neurocrine Biosciences, Inc, Department of Molecular Medicine, 12790 El Camino Real, San Diego, CA 92130, USA
    Genome Biol 7:243. 2006
    ..This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human.
  40. ncbi Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines
    Laura Pelosi
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Via A Scarpa, 14 Rome 00161, Italy
    FASEB J 21:1393-402. 2007
    ..such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and modulated the expression of CC chemokines involved in the recruitment of monocytes/macrophages...
  41. pmc The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques
    Yichuan Wang
    California National Primate Research Center, University of California Davis, Davis, California 95616, USA
    J Virol 79:14355-70. 2005
    ..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
  42. pmc Chemokines in health and disease
    Dayanidhi Raman
    Department of Cancer Biology, Vanderbilt University, School of Medicine, USA
    Exp Cell Res 317:575-89. 2011
    b>Chemokines and their receptors play a key role in development and homeostasis as well as in the pathogenesis of tumors and autoimmune diseases...
  43. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
    ..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
  44. ncbi Closed head injury--an inflammatory disease?
    Oliver I Schmidt
    Department of Trauma and Reconstructive Surgery, Charité University Medical School Berlin, Campus Benjamin Franklin, Germany
    Brain Res Brain Res Rev 48:388-99. 2005
    ..the so far known mechanisms of posttraumatic neuroinflammation after CHI, based on data from clinical and experimental studies, with a special focus on the role of pro-inflammatory cytokines, chemokines, and the complement system.
  45. pmc Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis
    Jaap G Neels
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:20692-8. 2009
    ..These studies suggest that KC and its receptor CXCR2 are potential targets for the development of new therapeutic approaches for treatment of obesity-related insulin resistance, type II diabetes, and related cardiovascular diseases...
  46. ncbi Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases
    Laetitia Cartier
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Brain Res Rev 48:16-42. 2005
    b>Chemokines were originally described as chemotactic cytokines involved in leukocyte trafficking. Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes...
  47. ncbi Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice
    Niels R Veillard
    Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circ Res 94:253-61. 2004
    ..Recruitment of leukocytes within the vascular wall, controlled by chemokines, is an essential process in the development of this common disease...
  48. ncbi Chemokines in atherosclerosis: an update
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Germany
    Arterioscler Thromb Vasc Biol 28:1897-908. 2008
    The fundamental importance of chemokines for atherogenesis, progression, and destabilization of atherosclerotic plaques is now widely appreciated, but the degree of complexity, specificity, and cooperativity harnessed by these signal ..
  49. pmc Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population
    Kiymet Bozaoglu
    Metabolic Research Unit, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3218, Australia
    J Clin Endocrinol Metab 94:3085-8. 2009
    ..Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in a small sample of subjects from Mauritius...
  50. doi Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
    Benjamin Bondue
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Cytokine Growth Factor Rev 22:331-8. 2011
    ..Both chemerin and ChemR23 are also expressed by adipocytes, and the emerging role of chemerin as an adipokine regulating lipid and carbohydrate metabolism is an area of intense research...
  51. pmc Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:1209-16. 2006
    ..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
  52. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  53. pmc Natural hemozoin stimulates syncytiotrophoblast to secrete chemokines and recruit peripheral blood mononuclear cells
    N W Lucchi
    Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    Placenta 32:579-85. 2011
    ....
  54. ncbi Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules
    João B Calixto
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina UFSC, Florianopolis, SC, Brazil
    Planta Med 70:93-103. 2004
    ..PK:protein kinase PMA/TPA:phorbol myristate acetate RANTES:regulated upon activation normal T-cell expressed and secreted TGF-beta:transforming growth factor-beta TNFalpha:tumour necrosis factor VCAM-1:vascular cell adhesion molecule-1..
  55. doi Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University Heidelberg, Germany
    Clin Cancer Res 17:678-89. 2011
    ..The contribution of intratumoral cytokines and chemokines in shaping the composition of the inflammatory lymphocytic infiltrate is also unclear.
  56. pmc The blood-brain barrier, chemokines and multiple sclerosis
    David W Holman
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochim Biophys Acta 1812:220-30. 2011
    ..An important step in this cascade is the presence of chemokines on the vascular endothelial cell surface...
  57. ncbi The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008
    ..leukocyte infiltration; the expression of cytokines such as tumor necrosis factor (TNF) or interleukin (IL)-1; chemokines such as CCL2 and CXCL8; active tissue remodelling and neo-angiogenesis...
  58. pmc Role of chemokines in regulation of immunity against leishmaniasis
    Steve Oghumu
    Department of Pathology, The Ohio State University Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA
    Exp Parasitol 126:389-96. 2010
    ..immunity to Leishmania depends on recruitment of appropriate immune effector cells to the site of infection and chemokines play a crucial role in the process...
  59. doi Immunologic messenger molecules: cytokines, interferons, and chemokines
    Scott P Commins
    University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:S53-72. 2010
    Cytokines and chemokines are secreted proteins involved in numerous aspects of cell growth, differentiation, and activation...
  60. pmc Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 207:763-76. 2010
    ..The release of these beta-chemokines explains both the specificity for R5 HIV-1 and the activity of these mAbs in PBMC cultures containing both ..
  61. ncbi Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
    Ana P Campanelli
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Hum Immunol 71:1220-7. 2010
    ..Therefore, different chemokines may affect the predominance of cell infiltration in distinct clinical manifestations...
  62. ncbi The biology of chemokines and their receptors
    D Rossi
    PharMingen Inc, San Diego, California 92121 1111, USA
    Annu Rev Immunol 18:217-42. 2000
    ..of bioinformatics and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors...
  63. ncbi Immunology of tuberculosis
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Immunol 19:93-129. 2001
    ..the induction, specificity, and effector functions of CD4(+) and CD8(+) T cells, and the roles of cytokines and chemokines in the induction and effector functions of the immune response...
  64. ncbi Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis
    Jaspreet Kaur
    Endocrinology and Metabolism Research Group, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
    Biochem Biophys Res Commun 391:1762-8. 2010
    ..01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity...
  65. doi Chemokines in the vascular inflammatory response of atherosclerosis
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 86:192-201. 2010
    ..In addition, the progression of atherosclerosis is determined by a disturbed equilibrium of immune responses. Chemokines and their receptors are instrumental in orchestrating the influx of leucocytes to the vascular wall, but also ..
  66. ncbi Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis
    Uwe Ritter
    Nikolaus Fiebiger Zentrum für Molekulare Medizin, University of Erlangen Nurnberg, Erlangen, Germany
    Parasite Immunol 24:295-301. 2002
    ..Based on this evidence, we propose that tissue specific expression of these small molecules actively regulates cell traffic and tissue localization of effector cells and, additionally, has direct immunological effects...
  67. ncbi Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
    Markus Krumbholz
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Brain 129:200-11. 2006
    ..This study focused on the chemokines CXCL12 (SDF-1) and CXCL13 (BCA-1), both of which regulate B cell migration in lymphoid tissues...
  68. pmc Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines
    Basam Z Barkho
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Stem Cells 26:3139-49. 2008
    ..Here we demonstrate that in response to two injury-induced chemokines, stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor, aNPCs differentiated into ..
  69. pmc Chemokines regulate the migration of neural progenitors to sites of neuroinflammation
    Abdelhak Belmadani
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurosci 26:3182-91. 2006
    ..slice cultures, grafted neural progenitor cells (NPs) migrate toward areas of neuroinflammation and that chemokines are a major regulator of this process...
  70. ncbi The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    E Oberlin
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Nature 382:833-5. 1996
    ..blood lymphocytes, SDF-1 is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains, whereas the CC chemokines RANTES, MIP-1 alpha and MIP-1 beta, which were shown previously to prevent infection with primary, monocyte-..
  71. doi Effect of posttranslational processing on the in vitro and in vivo activity of chemokines
    Anneleen Mortier
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Exp Cell Res 317:642-54. 2011
    ..Hence, chemokines function in a complex network to mediate migration of the various leukocyte subsets, expressing specific GPCRs ..
  72. ncbi Experimental stroke induces massive, rapid activation of the peripheral immune system
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:654-65. 2006
    ..We quantified mRNA and protein levels for cytokines, chemokines, and chemokine receptors (CCR) in brain, spinal cord, peripheral lymphoid organs (spleen, lymph node, blood, and ..
  73. ncbi Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets
    Valeria Sordi
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, H S Raffaele Telethon Institute for Gene Therapy, and Renal Pathophysiology Laboratory, Division of Medicine, Via Olgettina 60, 20132 Milan, Italy
    Blood 106:419-27. 2005
    ..chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19...
  74. pmc Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton
    Paul U Cameron
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Proc Natl Acad Sci U S A 107:16934-9. 2010
    ..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue...
  75. ncbi The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily
    L F Neville
    XTL Biopharmaceuticals, Rehovot, Israel
    Cytokine Growth Factor Rev 8:207-19. 1997
    ..This paper aims to highlight our current knowledge of IP-10 and its homologues as well as defining its likely involvement in regulating fibroproliferation following inflammatory lung injury...
  76. ncbi RANTES: a versatile and controversial chemokine
    V Appay
    Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK
    Trends Immunol 22:83-7. 2001
    ..RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans...
  77. ncbi HIV-1 infection and AIDS: consequences for the central nervous system
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 12:878-92. 2005
    ..This review will discuss recently uncovered pathologic neuroimmune and degenerative mechanisms contributing to neuronal damage induced by HIV-1 and potential approaches for development of future therapeutic intervention...
  78. pmc Chemerin, a novel adipokine in the regulation of angiogenesis
    Kiymet Bozaoglu
    Metabolic Research Unit, Deakin University, Geelong 3217, Australia
    J Clin Endocrinol Metab 95:2476-85. 2010
    ..Gene expression levels of chemerin were elevated in the adipose depots of obese compared with lean animals and was markedly elevated during differentiation of fibroblasts into mature adipocytes...
  79. pmc Chemokines as mediators of neovascularization
    Ellen C Keeley
    Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908 0466, USA
    Arterioscler Thromb Vasc Biol 28:1928-36. 2008
    b>Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation...
  80. pmc Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state
    Sif Hansdottir
    Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 1081, USA
    J Immunol 184:965-74. 2010
    ..Most importantly we found that, despite inducing IkappaBalpha and dampening chemokines and IFN-beta, there was no increase in viral mRNA or protein or in viral replication...
  81. ncbi Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy
    Edecio Cunha-Neto
    Laboratorio de Imunologia, Instituto do Coracao, Hospital das Clinicas, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 104:252-8. 2009
    ..In the last decade, increasing evidence has shown that inflammatory cytokines and chemokines play a role in the generation of the inflammatory infiltrate and tissue damage...
  82. pmc Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 78:1665-74. 2004
    b>Chemokines are likely to play important roles in the pathophysiology of diseases associated with Epstein-Barr virus (EBV). Here, we have analyzed the repertoire of chemokines expressed by EBV-infected B cells...
  83. pmc Chemokines and pain mechanisms
    Catherine Abbadie
    Department of Immunology, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
    Brain Res Rev 60:125-34. 2009
    ..two chemokine systems at the level of the dorsal root ganglia and spinal cord demonstrating that modulation of chemokines using selective antagonists decrease nociceptive behavior in rodent chronic pain models...
  84. ncbi Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease
    Sun Ying
    King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
    J Immunol 181:2790-8. 2008
    ..The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract them...
  85. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..The C-C chemokines RANTES, MIP-1 alpha and MIP-1 beta were recently identified as the major components of the HIV-SF produced by ..
  86. ncbi Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markers
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 26:194-9. 2006
    We investigated the association of several chemokines with the risk of stable coronary heart disease (CHD) in a large case-control study after adjustment for other established risk factors...
  87. ncbi Chemokines in host-parasite interactions in leishmaniasis
    Maria Jania Teixeira
    Centro de Pesquisas Goncalo Moniz, FIOCRUZ, Rua Waldemar Falcao 121, 40295 001 Salvador, Bahia, Brazil
    Trends Parasitol 22:32-40. 2006
    ..Cell recruitment to the site of infection is essential to the development of the host cellular immune response. The process is controlled by chemokines, which are chemotactic cytokines produced by leukocytes and tissue cells.
  88. ncbi Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women
    Edward C Suarez
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3328, Durham, NC 27710, USA
    Psychoneuroendocrinology 29:1119-28. 2004
    ....
  89. ncbi The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    FEBS Lett 500:52-5. 2001
    ..These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens...
  90. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
    ..experimental animal models and samples from clinical mobilization protocols demonstrate major involvement of chemokines such as stromal derived factor-1 (SDF-1) and IL-8, as well as proteolytic enzymes such as elastase, cathepsin G, ..
  91. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
    ..tubular damage, neutrophil and macrophage accumulation, and expression of proinflammatory cytokines and chemokines. In vitro, WT kidney TECs produced proinflammatory cytokines and chemokines and underwent apoptosis after ..
  92. ncbi Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Immunol 177:1817-24. 2006
    ....
  93. ncbi A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects
    Ingrid Dahlman
    Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden
    J Clin Endocrinol Metab 90:5834-40. 2005
    ..Low-grade inflammation in adipose tissue may contribute to insulin resistance in obesity. However, the roles of individual inflammatory mediators in adipose tissue are poorly understood...
  94. ncbi Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
    C Herder
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, 40225, Dusseldorf, Germany
    Diabetologia 49:921-9. 2006
    The chemokines monocyte chemoattractant protein-1 (MCP-1), IL-8 and interferon-gamma-inducible protein-10 (IP-10) are released by adipocytes and appear to be involved in atherosclerosis...
  95. ncbi Chemokines and tuberculosis
    Holly M Scott Algood
    Department of Molecular Genetics and Biochemistry and Molecular Virology and Microbiology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cytokine Growth Factor Rev 14:467-77. 2003
    ..The signals responsible for granuloma formation and maintenance are largely unknown. Since chemokines and chemokine receptors direct cells to specific sites within the tissues, it is plausible that these cells ..
  96. ncbi Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and Copaxone
    Juliana Croitoru-Lamoury
    Centre for Immunology, St Vincent s Hospital, Department of Neurology, Sydney NSW, Australia
    J Interferon Cytokine Res 27:53-64. 2007
    ..b>Chemokines are key mediators of selective cell migration in neurodegenerative diseases and related inflammatory processes...
  97. pmc Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157)
    Vivian Berg
    Department of Laboratory Medicine, University Hospital of North Norway, Sykehusveien 38, N 9038, Tromsø, Norway
    Arthritis Res Ther 12:R228. 2010
    ..In the present study, we aimed to clarify whether human chondrocytes express ChemR23 and chemerin, and whether chemerin/ChemR23 signalling could affect secretion of inflammatory mediators...
  98. doi Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis
    Hatice Bilgic
    University of Minnesota, Minneapolis, MN 55455, USA
    Arthritis Rheum 60:3436-46. 2009
    Up-regulation of whole blood type I interferon (IFN)-driven transcripts and chemokines has been described in a number of autoimmune diseases...
  99. pmc Mediators of inflammation in acute kidney injury
    Ali Akcay
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80262, USA
    Mediators Inflamm 2009:137072. 2009
    ..The injury induces the generation of inflammatory mediators like cytokines and chemokines by tubular and endothelial cells which contribute to the recruiting of leukocytes into the kidneys...
  100. pmc Chemokine receptor CCR5: from AIDS to atherosclerosis
    K L Jones
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
    Br J Pharmacol 162:1453-69. 2011
    There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease...
  101. pmc Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin
    William Vermi
    Department of Pathology, University of Brescia, 25123 Brescia, Italy
    J Exp Med 201:509-15. 2005
    ....

Research Grants83

  1. Project 1: In vitro Studies: Correlate the physical and chemical characteristics
    David L Eaton; Fiscal Year: 2011
    ..especially when taken up by tissue macrophages that can elaborate pro-inflammatory cytokines and chemokines [38-40]...
  2. CHEMOKINE-MEDIATED NEUROPROTECTION AND REPAIR DURING WNV ENCEPHALITIS
    ROBYN SUE KLEIN; Fiscal Year: 2010
    ..The long term experimental objective of this competitive renewal is to evaluate the functional roles of chemokines and their receptors in contributing to viral clearance, immunopathology and repair in a murine model of WNV ..
  3. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..but not non-infected RBC activate BBB endothelium: increase ICAM-1 expression on HBMEC, release cytokines &chemokines and decrease barrier integrity...
  4. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    DEAN YAMAGUCHI; Fiscal Year: 2009
    ..A key step of bone repair occurs in the early inflammatory phase where there is an elaboration of CXC chemokines. CXC chemokines having a signature glu-leu-arg (ELR) sequence upstream to the CXC motif (ELR+ CXC chemokines) ..
  5. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 2000
    ..Recent advances in molecular cloning of cellular chemoattractants called chemokines have opened a new avenue to determine the means by which the body controls the influx of cells...
  6. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 1999
    ..Recent advances in molecular cloning of cellular chemoattractants called chemokines have opened a new avenue to determine the means by which the body controls the influx of cells...
  7. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2004
    ..Several studies have shown the ability of cytokines and chemokines to facilitate the release of ET-1...
  8. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2006
    ..Several studies have shown the ability of cytokines and chemokines to facilitate the release of ET-1...
  9. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2005
    ..Several studies have shown the ability of cytokines and chemokines to facilitate the release of ET-1...
  10. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2002
    ..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
  11. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2000
    ..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
  12. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 1999
    ..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
  13. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2001
    ..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
  14. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2003
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  15. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2005
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  16. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2004
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  17. ELR-CXC Chemokines In Lung Antibacterial Host Defense
    Theodore Standiford; Fiscal Year: 2002
    ..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
  18. IL-13 Associated Eosinophil Lung Responses
    MARC ROTHENBERG; Fiscal Year: 2009
    ..Extensive studies have also demonstrated a central role for chemokines in orchestrating multiple aspects of the asthmatic response...
  19. The Ron Receptor/Chemokine Axis in Prostate Cancer
    Susan Waltz; Fiscal Year: 2009
    ..Our preliminary data show that prostate cancer cell lines and tumors produce angiogenic CXC chemokines through a mechanism dependent on NF-:B activation...
  20. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2010
    ..Extensive studies have also demonstrated a central role for chemokines in orchestrating multiple aspects of the asthmatic response...
  21. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..encephalitis, and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and cytokines in the brain...
  22. Viral Encephalitis, Chemokines and Sleep
    LARRY SANFORD; Fiscal Year: 2009
    ..encephalitis, and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and cytokines in the brain...
  23. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..e. CC chemokines MIP-1a, MIP-1[unreadable], and RANTES by the cells...
  24. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    CATARINA HIOE; Fiscal Year: 2009
    ..e. CC chemokines MIP-1a, MIP-1[unreadable], and RANTES by the cells...
  25. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2005
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  26. Inflammatory Breast Cancer: Factors Contributing to Dissemination
    Bonnie F Sloane; Fiscal Year: 2010
    ..determine expression/localization of putative IBC marker proteins;c) quantify expression of cytokines, chemokines and growth factors in conditioned media;and d) expression/secretion/activity of cysteine cathepsins;2) ..
  27. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2003
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  28. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  29. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2009
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  30. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2004
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  31. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2006
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  32. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2007
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  33. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2002
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  34. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2001
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
  35. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2003
    ..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
  36. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2005
    ..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
  37. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2006
    ..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
  38. The Role of IL-17 Axis in Inflammatory Myositis
    ANN M contact REED; Fiscal Year: 2010
    ..and serum levels of the pro-inflammatory cytokine interleukin-17 (IL-17) and type-I interferon (IFN) regulated chemokines. Further, high levels of IL-17 and IFN-related chemokines are detected in muscle biopsies from both DM patients ..
  39. Opioids,Cannabinoids,Chemokines--Neuroimmune Interaction
    Martin Adler; Fiscal Year: 2001
    ..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
  40. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2004
    ..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
  41. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2002
    ..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
  42. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2000
    ..b>Chemokines are a family of proteins that are resistant to inactivation by pH or proteolysis as well as affect the ..
  43. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    ..b>Chemokines are a family of proteins that are resistant to inactivation by pH or proteolysis as well as affect the ..
  44. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2001
    ..b>Chemokines are a family of proteins that are resistant to inactivation by pH or proteolysis as well as affect the ..
  45. CHEMOKINES AND HIV REPLICATION IN ALVEOLAR MACROPHAGES
    Michael Coffey; Fiscal Year: 2000
    ..The objective of this proposal is to examine the role C-C chemokines play in the regulation of HIV replication in AM...
  46. CHEMOKINES AND HIV REPLICATION IN ALVEOLAR MACROPHAGES
    Michael Coffey; Fiscal Year: 1999
    ..The objective of this proposal is to examine the role C-C chemokines play in the regulation of HIV replication in AM...
  47. NF-kB Signaling in Osteoclastogenesis and Osteolytic Bone Metastasis
    Cun Yu Wang; Fiscal Year: 2009
    ..transcription factor which regulates a broad range of gene expression, including pro-inflammatory cytokines, chemokines and cell adhesion molecules...
  48. NF-kB Signaling in Osteoclastogenesis and Osteolytic Bone Metastasis
    Cun Yu Wang; Fiscal Year: 2010
    ..transcription factor which regulates a broad range of gene expression, including pro-inflammatory cytokines, chemokines and cell adhesion molecules...
  49. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..Leukocyte adhesion to endothelium is mediated through both chemokines and adhesion molecules on ECs, and the expression of these molecules is critically up- regulated by nuclear ..
  50. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2002
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  51. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2001
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  52. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2000
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  53. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 1999
    ..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
  54. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 2000
    ..The main focus of the research will be on C-X-C chemokines. C-X-C chemokines are potent neutrophil chemoattractants and activators; when produced in the liver in vivo, ..
  55. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 1999
    ..The main focus of the research will be on C-X-C chemokines. C-X-C chemokines are potent neutrophil chemoattractants and activators; when produced in the liver in vivo, ..
  56. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    ..The chemokines Interleukin-8 (IL8) and Growth-Regulated Oncogene alpha (GROalpha) control much of the normal function of ..
  57. Chemokines and Th2 Cell Trafficking in Asthma
    Andrew D Luster; Fiscal Year: 2010
    ..into the asthmatic lung is initiated by the activation of mast cells and the release of leukotriene B4 and chemokines. This is followed by a Propagation Phase that is mediated by activation of Toll-like receptors (TLRs) on innate ..
  58. Chemokines and Th2 Cell Trafficking in Asthma
    Andrew D Luster; Fiscal Year: 2011
    ..into the asthmatic lung is initiated by the activation of mast cells and the release of leukotriene B4 and chemokines. This is followed by a Propagation Phase that is mediated by activation of Toll-like receptors (TLRs) on innate ..
  59. Chemokines and Th2 Cell Trafficking in Asthma
    Andrew Luster; Fiscal Year: 2009
    ..into the asthmatic lung is initiated by the activation of mast cells and the release of leukotriene B4 and chemokines. This is followed by a Propagation Phase that is mediated by activation of Toll-like receptors (TLRs) on innate ..
  60. REGULATION OF DIABETES BY CHEMOKINES
    Linda Bradley; Fiscal Year: 2000
    ..b>Chemokines regulate adhesion of cells to vascular endothelium and, via chemoattractant effects, govern cellular recruitment ..
  61. REGULATION OF DIABETES BY CHEMOKINES
    Linda Bradley; Fiscal Year: 2001
    ..b>Chemokines regulate adhesion of cells to vascular endothelium and, via chemoattractant effects, govern cellular recruitment ..
  62. REGULATION OF DIABETES BY CHEMOKINES
    Linda Bradley; Fiscal Year: 1999
    ..b>Chemokines regulate adhesion of cells to vascular endothelium and, via chemoattractant effects, govern cellular recruitment ..
  63. REGULATION OF DIABETES BY CHEMOKINES
    Linda Bradley; Fiscal Year: 2001
    ..b>Chemokines regulate adhesion of cells to vascular endothelium and, via chemoattractant effects, govern cellular recruitment ..
  64. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor L Perez; Fiscal Year: 2010
    ..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
  65. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor Perez; Fiscal Year: 2009
    ..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
  66. Hydrogen Deuterium Exchange Mapping of Chemokine Receptor Complex Interfaces
    Tracy Handel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chemokines are critical mediators of cell migration during immune surveillance, lymphocyte development, and inflammation...
  67. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor Perez; Fiscal Year: 2009
    ..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
  68. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor L Perez; Fiscal Year: 2010
    ..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
  69. The Role of C-C Chemokines in Eosinophil Airway Inflammation
    Nicholas Lukacs; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This competitive renewal will build upon our previous work on the role of chemokines and their receptors in airway inflammation...
  70. Regulation of Chemokine Mediated Leukocyte Functions
    MICHELER RICHARDSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chemokines are multifunctional mediators responsible for recruitment and activation of the leukocyte at the site of inflammation...
  71. Regulation of Chemokine Mediated Leukocyte Functions
    Micheler Ricardo Richardson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chemokines are multifunctional mediators responsible for recruitment and activation of the leukocyte at the site of inflammation...
  72. Chemokine antagonists in a murine model for scleroderma
    Anita Gilliam; Fiscal Year: 2001
    ..RT/PCR analysis of total skin RNA and flow cytometry of single skin cell preparations and found that mRNAs for chemokines such as macrophage chemoattractant protein (MCP-1/JE), macrophage inhibitory protein (MIP-1alpha) and RANTES are ..
  73. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 1999
    ..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...
  74. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2004
    Three chemokines, CXCL9, CXCL10 and CXCL11, comprise the IFN-inducible non-ELR CXC chemokine subgroup...
  75. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2007
    Three chemokines, CXCL9, CXCL10 and CXCL11, comprise the IFN-inducible non-ELR CXC chemokine subgroup...
  76. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2006
    Three chemokines, CXCL9, CXCL10 and CXCL11, comprise the IFN-inducible non-ELR CXC chemokine subgroup...
  77. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2002
    ..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...
  78. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2005
    Three chemokines, CXCL9, CXCL10 and CXCL11, comprise the IFN-inducible non-ELR CXC chemokine subgroup...
  79. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2000
    ..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...
  80. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2003
    ..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...
  81. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2001
    ..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...
  82. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2003
    ..The chemokines Interleukin-8 (IL8) and Growth-Regulated Oncogene alpha (GROalpha) control much of the normal function of ..
  83. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..Leukocyte adhesion to endothelium is mediated through both chemokines and adhesion molecules on ECs, and the expression of these molecules is critically up-regulated by nuclear ..