Genomes and Genes
Summary: Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Publications301 found, 100 shown here
- Inflammation and cancerLisa M Coussens
Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
Nature 420:860-7. 2002..tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis...
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptorY Feng
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
Science 272:872-7. 1996..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
- Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesAlberto Mantovani
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
Trends Immunol 23:549-55. 2002..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
- Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxideGuangwen Ren
Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
Cell Stem Cell 2:141-50. 2008..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
- The many roles of chemokines and chemokine receptors in inflammationIsrael F Charo
Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
N Engl J Med 354:610-21. 2006
- The role of chemokines in neutrophil biologyYoshiro Kobayashi
Division of Molecular Medicine, Dept of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan
Front Biosci 13:2400-7. 2008..Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment...
- Alternative activation of macrophagesSiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 3:23-35. 2003..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
- Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injuryJenna M Ziebell
National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, VIC 3181, Australia
Neurotherapeutics 7:22-30. 2010..This review addresses the role of several cytokines and chemokines following focal and diffuse TBI, as well as the controversies around the use of therapeutic anti-inflammatory ..
- Chemokines in liver inflammation and fibrosisHermann E Wasmuth
Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
Semin Liver Dis 30:215-25. 2010b>Chemokines are a class of small chemotactic molecules with cytokine-like functions, which are well known to orchestrate inflammatory responses within different organs. Overall, more than 50 ligands and 19 receptors belong to the network...
- Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritisHeidi Kokkonen
Umea University Hospital, Umea, Sweden
Arthritis Rheum 62:383-91. 2010To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA).
- Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion moleculesJoão B Calixto
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina UFSC, Florianopolis, SC, Brazil
Planta Med 70:93-103. 2004..PK:protein kinase PMA/TPA:phorbol myristate acetate RANTES:regulated upon activation normal T-cell expressed and secreted TGF-beta:transforming growth factor-beta TNFalpha:tumour necrosis factor VCAM-1:vascular cell adhesion molecule-1..
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004....
- Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitmentM Romano
Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
Immunity 6:315-25. 1997..to a reduced migratory capacity of IL-6-/- leukocytes and was associated with a reduced in situ production of chemokines. These observations led to a reexamination of the interaction of IL-6 with endothelial cells (EC)...
- Orchestrating the orchestrators: chemokines in control of T cell trafficShannon K Bromley
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Nat Immunol 9:970-80. 2008The understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors have been identified...
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Heon Park
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1133-41. 2005..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
- The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaquesYichuan Wang
California National Primate Research Center, University of California-Davis, Davis, California 95616, USA
J Virol 79:14355-70. 2005..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
- Chemokine receptors and their role in inflammation and infectious diseasesC Murdoch
Division of Child Health, University of Sheffield, Sheffield Children s Hospital, Sheffield, United Kingdom
Blood 95:3032-43. 2000b>Chemokines are small peptides that are potent activators and chemoattractants for leukocyte subpopulations and some nonhemopoietic cells...
- Identification of a major co-receptor for primary isolates of HIV-1H Deng
Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
Nature 381:661-6. 1996..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
- Chemokines in atherosclerosis: an updateAlma Zernecke
Institute for Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Germany
Arterioscler Thromb Vasc Biol 28:1897-908. 2008The fundamental importance of chemokines for atherogenesis, progression, and destabilization of atherosclerotic plaques is now widely appreciated, but the degree of complexity, specificity, and cooperativity harnessed by these signal ..
- Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesisJaspreet Kaur
Endocrinology and Metabolism Research Group, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
Biochem Biophys Res Commun 391:1762-8. 2010..01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity...
- Immunology of tuberculosisJ L Flynn
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Annu Rev Immunol 19:93-129. 2001..the induction, specificity, and effector functions of CD4(+) and CD8(+) T cells, and the roles of cytokines and chemokines in the induction and effector functions of the immune response...
- Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokinesBasam Z Barkho
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
Stem Cells 26:3139-49. 2008..Here we demonstrate that in response to two injury-induced chemokines, stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor, aNPCs differentiated into ..
- Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteriaFrank A W Verreck
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
Proc Natl Acad Sci U S A 101:4560-5. 2004..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
- Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeletonPaul U Cameron
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
Proc Natl Acad Sci U S A 107:16934-9. 2010..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue...
- Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseasesLaetitia Cartier
Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 chemin du Petit-Bel Air, , Switzerland
Brain Res Brain Res Rev 48:16-42. 2005b>Chemokines were originally described as chemotactic cytokines involved in leukocyte trafficking. Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes...
- Chemokines and chemokine receptors: new insights into cancer-related inflammationGwendal Lazennec
INSERM, U844, Site Saint Eloi Bâtiment INM 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F 34090, France
Trends Mol Med 16:133-44. 2010b>Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation...
- Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic isletsValeria Sordi
Telethon-Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, H. S. Raffaele-Telethon Institute for Gene Therapy, and Renal Pathophysiology Laboratory, Division of Medicine, Via Olgettina 60, 20132 Milan, Italy
Blood 106:419-27. 2005..chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19...
- The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamilyL F Neville
XTL Biopharmaceuticals, Rehovot, Israel
Cytokine Growth Factor Rev 8:207-19. 1997..This paper aims to highlight our current knowledge of IP-10 and its homologues as well as defining its likely involvement in regulating fibroproliferation following inflammatory lung injury...
- HIV-1 infection and AIDS: consequences for the central nervous systemM Kaul
Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Death Differ 12:878-92. 2005..This review will discuss recently uncovered pathologic neuroimmune and degenerative mechanisms contributing to neuronal damage induced by HIV-1 and potential approaches for development of future therapeutic intervention...
- Chemerin is a novel adipokine associated with obesity and metabolic syndromeKiymet Bozaoglu
Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
Endocrinology 148:4687-94. 2007..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
- Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary diseaseSun Ying
King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
J Immunol 181:2790-8. 2008..The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract them...
- RANTES: a versatile and controversial chemokineV Appay
Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK
Trends Immunol 22:83-7. 2001..RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans...
- Chemokines and pain mechanismsCatherine Abbadie
Department of Immunology, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
Brain Res Rev 60:125-34. 2009..two chemokine systems at the level of the dorsal root ganglia and spinal cord demonstrating that modulation of chemokines using selective antagonists decrease nociceptive behavior in rodent chronic pain models...
- Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathyEdecio Cunha-Neto
Laboratorio de Imunologia, Instituto do Coracao, Hospital das Clinicas, Sao Paulo, SP, Brasil
Mem Inst Oswaldo Cruz 104:252-8. 2009..In the last decade, increasing evidence has shown that inflammatory cytokines and chemokines play a role in the generation of the inflammatory infiltrate and tissue damage...
- The biology of chemokines and their receptorsD Rossi
PharMingen Inc, San Diego, California 92121 1111, USA
Annu Rev Immunol 18:217-42. 2000..of bioinformatics and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors...
- Antagonism of RANTES receptors reduces atherosclerotic plaque formation in miceNiels R Veillard
Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
Circ Res 94:253-61. 2004..Recruitment of leukocytes within the vascular wall, controlled by chemokines, is an essential process in the development of this common disease...
- Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virusTakashi Nakayama
Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
J Virol 78:1665-74. 2004b>Chemokines are likely to play important roles in the pathophysiology of diseases associated with Epstein-Barr virus (EBV). Here, we have analyzed the repertoire of chemokines expressed by EBV-infected B cells...
- Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markersDietrich Rothenbacher
Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
Arterioscler Thromb Vasc Biol 26:194-9. 2006OBJECTIVE: We investigated the association of several chemokines with the risk of stable coronary heart disease (CHD) in a large case-control study after adjustment for other established risk factors...
- Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral stateSif Hansdottir
Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 1081, USA
J Immunol 184:965-74. 2010..Most importantly we found that, despite inducing IkappaBalpha and dampening chemokines and IFN-beta, there was no increase in viral mRNA or protein or in viral replication...
- Chemokines as mediators of neovascularizationEllen C Keeley
Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908 0466, USA
Arterioscler Thromb Vasc Biol 28:1928-36. 2008b>Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation...
- Chemokines in host-parasite interactions in leishmaniasisMaria Jania Teixeira
, FIOCRUZ, , 40295-001 Salvador, Bahia, Brazil
Trends Parasitol 22:32-40. 2006..Cell recruitment to the site of infection is essential to the development of the host cellular immune response. The process is controlled by chemokines, which are chemotactic cytokines produced by leukocytes and tissue cells.
- The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionF Cocchi
Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
Nat Med 2:1244-7. 1996..The C-C chemokines RANTES, MIP-1 alpha and MIP-1 beta were recently identified as the major components of the HIV-SF produced by ..
- TLR4 activation mediates kidney ischemia/reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
J Clin Invest 117:2847-59. 2007..tubular damage, neutrophil and macrophage accumulation, and expression of proinflammatory cytokines and chemokines. In vitro, WT kidney TECs produced proinflammatory cytokines and chemokines and underwent apoptosis after ..
- The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokinesT Krakauer
Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
FEBS Lett 500:52-5. 2001..These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens...
- Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion moleculesSusanne Herold
University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
J Immunol 177:1817-24. 2006....
- Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cellsTsvee Lapidot
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Exp Hematol 30:973-81. 2002..experimental animal models and samples from clinical mobilization protocols demonstrate major involvement of chemokines such as stromal derived factor-1 (SDF-1) and IL-8, as well as proteolytic enzymes such as elastase, cathepsin G, ..
- A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjectsIngrid Dahlman
Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden
J Clin Endocrinol Metab 90:5834-40. 2005..Among seven markedly overexpressed chemokines, only monocyte chemoattractant protein 1 (MCP1) was released from adipose tissue and isolated fat cells in vitro...
- Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluidsValerie Wittamer
Institut de Recherche en Biologie Humaine et Moléculaire, ULB Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
J Exp Med 198:977-85. 2003..Therefore, chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs...
- Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy womenEdward C Suarez
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3328, Durham, NC 27710, USA
Psychoneuroendocrinology 29:1119-28. 2004....
- Chemokines and tuberculosisHolly M Scott Algood
Department of Molecular Genetics and Biochemistry and Molecular Virology and Microbiology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Cytokine Growth Factor Rev 14:467-77. 2003..The signals responsible for granuloma formation and maintenance are largely unknown. Since chemokines and chemokine receptors direct cells to specific sites within the tissues, it is plausible that these cells ..
- Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002C Herder
German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, 40225, Dusseldorf, Germany
Diabetologia 49:921-9. 2006The chemokines monocyte chemoattractant protein-1 (MCP-1), IL-8 and interferon-gamma-inducible protein-10 (IP-10) are released by adipocytes and appear to be involved in atherosclerosis...
- Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and CopaxoneJuliana Croitoru-Lamoury
Centre for Immunology, St Vincent s Hospital, Department of Neurology, Sydney NSW, Australia
J Interferon Cytokine Res 27:53-64. 2007..b>Chemokines are key mediators of selective cell migration in neurodegenerative diseases and related inflammatory processes...
- Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skinWilliam Vermi
Department of Pathology, University of Brescia, 25123 Brescia, Italy
J Exp Med 201:509-15. 2005....
- Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis CMarija Zeremski
Department of Medicine, Division of Gastroenterology and Hepatology, The Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, NY 10065, USA
Hepatology 48:1440-50. 2008b>Chemokines, chemotactic cytokines, may promote hepatic inflammation in chronic hepatitis C virus (HCV) infection through the recruitment of lymphocytes to the liver parenchyma...
- CCAAT displacement protein regulates nuclear factor-kappa beta-mediated chemokine transcription in melanoma cellsYukiko Ueda
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Melanoma Res 17:91-103. 2007..The promoter activity of NF-kappaB-regulated chemokines was also reduced by the expression of dominant-negative PCAF...
- Mediators of inflammation in acute kidney injuryAli Akcay
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80262, USA
Mediators Inflamm 2009:137072. 2009..The injury induces the generation of inflammatory mediators like cytokines and chemokines by tubular and endothelial cells which contribute to the recruiting of leukocytes into the kidneys...
- Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositisHatice Bilgic
University of Minnesota, Minneapolis, MN 55455, USA
Arthritis Rheum 60:3436-46. 2009Up-regulation of whole blood type I interferon (IFN)-driven transcripts and chemokines has been described in a number of autoimmune diseases...
- Chemokine receptor CCR5: from AIDS to atherosclerosisK L Jones
Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
Br J Pharmacol 162:1453-69. 2011There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease...
- Chemokines direct neural progenitor cell migration following striatal cell lossRenee J Gordon
Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Mol Cell Neurosci 41:219-32. 2009In this study we demonstrate the chemokines MCP-1, MIP-1alpha and GRO-alpha play a role in directing adult subventricular zone (SVZ)-derived progenitor cell migration following striatal cell death...
- High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivoChristina A Bursill
Heart Research Institute, 7 Eliza St, Sydney, New South Wales 2042, Australia
Arterioscler Thromb Vasc Biol 30:1773-8. 2010..To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX(3)CL1) and chemokine receptor (CCR2 and CX(3)CR1) expression, a mechanism for the atheroprotective properties of HDLs...
- Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasisAna P Campanelli
Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
Hum Immunol 71:1220-7. 2010..Therefore, different chemokines may affect the predominance of cell infiltration in distinct clinical manifestations...
- Chemokine binding proteins encoded by pathogensAntonio Alcami
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
Adv Exp Med Biol 666:167-79. 2009b>Chemokines are chemoattractant cytokines that play an important role in immunity. The role of chemokines against invading pathogens is emphasized by the expression of chemokine inhibitors by many pathogens...
- The role of cytokines/chemokines in the pathogenesis of atopic dermatitisKei Ichi Yamanaka
Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan
Curr Probl Dermatol 41:80-92. 2011..These novel approaches may constitute a potential curative therapy for AD...
- Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous systemWilliam Rostene
Institut de la Vision UMRS INSERM UPMC 968, Paris, France
J Neurochem 118:680-94. 2011Recent observations suggest that besides their role in the immune system, chemokines have important functions in the brain...
- Chemokine signaling via the CXCR2 receptor reinforces senescenceJuan C Acosta
Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, W12 0NN London, UK
Cell 133:1006-18. 2008..Cells undergoing OIS secrete multiple CXCR2-binding chemokines in a program that is regulated by the NF-kappaB and C/EBPbeta transcription factors and coordinately induce ..
- Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasksMary F Barbe
Department of Physical Therapy, College of Health Professions, Temple University, 3307 North Broad Streeet, Philadelphia, PA 19140, USA
J Orthop Res 26:1320-6. 2008..Serum was assayed for 11 cytokines and chemokines; forelimb tissues for four cytokines...
- Imaging chemokine receptor dimerization with firefly luciferase complementationKathryn E Luker
Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, 109 Zina Pitcher Pl, A526 BSRB, Ann Arbor, MI 48109 2200, USA
FASEB J 23:823-34. 2009..b>Chemokines regulated reporter bioluminescence for CXCR4 or CXCR7 homodimers without affecting signals from receptor ..
- Peripheral cytokines and chemokines in Alzheimer's diseaseKang Soo Lee
Department of Psychiatry, CHA University, Bundang Cha Medical Center, Seongnam, Korea
Dement Geriatr Cogn Disord 28:281-7. 2009..Interleukins 1, 4, 6, 10, 12, 16, and 18, tumour necrosis factor, and several chemokines have been suggested as biomarkers of AD...
- Chemokines and leukocyte trafficFederica Sallusto
Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
Nat Immunol 9:949-52. 2008Twenty years after the discovery of chemokines is an appropriate time to review leukocyte traffic and to assess the knowledge and opportunities that have arisen from countless studies of the large and tight-knit family of chemotactic ..
- Neuro-immune crosstalk in CNS diseasesM Kerschensteiner
Institute of Clinical Neuroimmunology, Ludwig Maximilians University Munich, Marchioninistr 17, 81377 Munich, Germany
Neuroscience 158:1122-32. 2009..It is thus the balance between destructive and protective factors that ultimately determines the net result of the neuro-immune interaction...
- Assessing activation states in microgliaCarol A Colton
Duke University Medical Center, Durham, NC 27710, USA
CNS Neurol Disord Drug Targets 9:174-91. 2010..A broad-based functional view is provided that is designed to more fully explore the balance between inflammo-toxic and inflammo-resolution factors that govern chronic disease progression...
- Molecular cues guiding inflammatory responsesOlga Barreiro
Departamento de Biología Vascular e Inflamación, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Cardiovasc Res 86:174-82. 2010..Soluble cues (cytokines and chemokines) and membrane receptors in both endothelium and leucocytes orchestrate the coordinated recruitment of specific ..
- Cytokines, chemokines and growth factors in endometrium related to implantationE Dimitriadis
Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
Hum Reprod Update 11:613-30. 2005..New data are also emerging for roles for a number of chemokines (chemoattractive cytokines) both in recruiting specific cohorts of leukocytes to implantation sites and in ..
- The role of chemokines as inflammatory mediators in chronic hepatitis C virus infectionM Zeremski
Division of Gastroenterology and Hepatology, Department of Medicine, and The Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York 10021, USA
J Viral Hepat 14:675-87. 2007..Intrahepatic inflammation and liver cell injury are defining features of chronic HCV infection. Chemokines, chemotactic cytokines that attract leucocytes to inflammatory sites, may be important in the development of ..
- Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patientsQiong Fu
Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shan Dong Middle Road, Shanghai 200001, PR China
Arthritis Res Ther 10:R112. 2008..In this study we correlated the combined expression level of multiple interferon-inducible chemokines with disease activity, degree of organ damage and clinical features in SLE, and we investigated their roles as ..
- Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosisShinobu Furuse
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
J Rheumatol 30:1524-8. 2003OBJECTIVE: To determine whether serum concentrations of 2 CXC chemokines, interleukin 8 (IL-8) and growth-regulated oncogene-alpha (GRO-alpha), which are potent chemoattractants and activators for neutrophils, are elevated and whether ..
- Chemokine homeostasis vs. chemokine presentation during severe acute lung injury: the other side of the Duffy antigen receptor for chemokinesAlexander Zarbock
Department of Anesthesiology and Critical Care Medicine, University of Munster, Munster, Germany
Am J Physiol Lung Cell Mol Physiol 298:L462-71. 2010Acute lung injury (ALI) still poses a major challenge in critical care medicine. Neutrophils, platelets, and chemokines are all considered key components in the development of ALI...
- Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligandPeter Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
Rheumatology (Oxford) 49:1867-77. 2010..The aim of the present study was to describe a broad spectrum of T- and B-cell cytokines, growth factors and chemokines in patients with idiopathic inflammatory myopathies (IIMs) and healthy individuals.
- Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancyPravin Mishra
Department of Medicine and Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
J Leukoc Biol 89:31-9. 2011..and fibroblasts that are found in their proximity in the growing and progressing tumor and describe the roles of chemokines in mediating such cross-talks...
- Pigment epithelium-derived factor induces the production of chemokines by rat microgliaAsako Takanohashi
Neurotrophic Factors Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-0151, USA
Glia 51:266-78. 2005..PEDF also activates NFkappaB, accompanied by the induction of mRNAs and proteins for the chemokines macrophage inflammatory protein-1alpha (MIP-1alpha, MIP-2, and MIP-3alpha...
- The role of chemokines in term and premature rupture of the fetal membranes: a reviewNardhy Gomez-Lopez
Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Research Direction, Distrito Federal, Mexico City, Mexico
Biol Reprod 82:809-14. 2010..the recruitment and homing of leukocytes to the reproductive tissues, and detail specific actions of the key chemokines released by the choriodecidual cells...
- Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicityO Meucci
Department of Pharmacological and Physiological Sciences, University of Chicago, 947 E 58th Street MC 0926, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 95:14500-5. 1998..Fura-2-based Ca imaging showed that numerous chemokines, including SDF-1alpha, RANTES, and fractalkine, affect neuronal Ca signaling, suggesting that hippocampal ..
- Carcinoma cell-derived chemokines and their presence in oral fluidKatleen Michiels
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
Eur J Oral Sci 117:362-8. 2009b>Chemokines are important in inflammation and in carcinogenesis. We hypothesized that besides oro-laryngeal cancer, oral inflammatory states, such as periodontitis, may also influence the chemokine profile of oral fluid...
- Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniaeNuria Rodriguez
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
Eur J Immunol 36:1145-55. 2006..pneumoniae partially depended on TLR2, but not on TLR4. The chemokines MIP-2 and MIP-1alpha were not induced, while IL-12p40 levels were higher in TLR2(-/-) mice compared to wild-type ..
- Effect of radiation on gene expression of rat liver chemokines: in vivo and in vitro studiesFederico Moriconi
Department of Gastroenterology and Endocrinology, Gottingen University, 37075 Goettingen, Germany
Radiat Res 169:162-9. 2008..Irradiation of the liver induces up-regulation of the genes of the main proinflammatory chemokines, probably through the action of locally synthesized proinflammatory cytokines...
- Tear cytokine profiles in dysfunctional tear syndromeHelene Lam
Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
Am J Ophthalmol 147:198-205. e1. 2009..To compare tear cytokine and chemokine concentrations in asymptomatic control and Dysfunctional Tear syndrome (DTS) patients and determine the correlations between tear inflammatory mediators and clinical severity...
- Chemokines and their receptors in central nervous system diseaseKnut Biber
University Medical Center Groningen UMCG, Department of Medical Physiology, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
Curr Drug Targets 7:29-46. 2006..Here recent developments concerning the role of chemokines in diseases of the central nervous system (CNS) as well as their possible therapeutic relevance are discussed.
- Interferon-gamma dose-dependently inhibits prostaglandin E2-mediated dendritic-cell-migration towards secondary lymphoid organ chemokinesJohn Alder
Institution of Laboratory Medicine, Department of Clinical Immunology, The Sahlgrenska University Hospital, , Sweden
Vaccine 24:7087-94. 2006..Important features for their efficacy include high migratory responsiveness to lymph node-chemokines and most likely their ability to produce bioactive IL-12 p70 upon subsequent contact with CD40 ligand-expressing ..
- Inflammatory mechanisms in ischemic stroke: therapeutic approachesShaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
J Transl Med 7:97. 2009..However, recent studies showing that regulatory T cells are major cerebroprotective immunomodulators after stroke suggest that targeting the endogenous adaptive immune response may offer novel promising neuroprotectant therapies...
- Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's diseaseMarcella Reale
Department of Oncology and Neuroscience, University G D Annunzio, Chieti, Italy
J Alzheimers Dis 14:147-59. 2008..whether spontaneous and mitogen stimulated production of peripheral blood mononuclear cell (PBMC) cytokines, chemokines and chemokine receptors in clinically diagnosed patients with AD were unregulated...
- p38 Mitogen-activated protein kinase signalling regulates vascular inflammation and epithelial barrier dysfunction in an experimental model of radiation-induced colitisA Mihaescu
Department of Surgery, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
Br J Surg 97:226-34. 2010..This study examined the role of p38 mitogen-activated protein kinase (p38 MAPK) signalling in radiation-induced colitis in an experimental model...
- Differential expression of chemokines and chemokine receptors in murine islet allografts: the role of CCR2 and CCR5 signaling pathwaysBernd Schroppel
Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Am Soc Nephrol 15:1853-61. 2004b>Chemokines and their receptors play a pivotal role in the initiation and amplification of the immune response. Investigated was their differential expression after syngeneic and allogeneic islet transplantation...
- Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in miceMark D Wareing
La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
J Leukoc Biol 76:886-95. 2004..IP-10) mRNA expression was up-regulated between days 5 and 15 after infection, consistent with a role for these chemokines in leukocyte recruitment to the lung...
- Impaired chemokine-induced migration during T-cell development in the absence of Jak 3Gloria Soldevila
Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico
Immunology 112:191-200. 2004..to the thymus, and the directed migration of thymocytes, are thought to be regulated by the expression of chemokines and their receptors...
- Impaired IgG production in mice deficient for heat shock transcription factor 1Sachiye Inouye
Departments of Biochemistry and Molecular Biology and Microbiology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
J Biol Chem 279:38701-9. 2004..We analyzed levels of cytokines and chemokines in spleen cells and in peritoneal macrophages stimulated with lipopolysaccharide and interferon-gamma and found ..
- CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammationKeisuke Takeshita
Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Disease Research, 6-5-1-3, Kunimidai, Kizu-cho, Soraku-gun, 619-0216 Kyoto, Japan
Int Immunol 16:947-59. 2004..Inflammatory cascades mediated by CRTH2 ligation may therefore represent an important early step in the elicitation and maintenance of Th2-dependent skin inflammation...
- Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophilsJia Sun
Dept of Pharmacology, National University of Singapore, Yong Loo Lin School of Medicine, Centre for Life Sciences, Singapore
Am J Physiol Cell Physiol 293:C696-704. 2007..SP induced both the mRNA and protein expression of the chemokines MIP-1alpha/CCL3 and MIP-2/CXCL2 in neutrophils and upregulated the chemokine receptors CC chemokine receptor (..
- Chemokine monokine induced by IFN-gamma/CXC chemokine ligand 9 stimulates T lymphocyte proliferation and effector cytokine productionDavid Whiting
Department of Surgery, Division of Cardiothoracic Surgery, David Geffen School of Medicine, University of California Los Angeles, UCLA Medical Center, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
J Immunol 172:7417-24. 2004..This novel observation expands our current understanding of MIG/CXCL9 biology beyond that of mediating T cell trafficking...
- MCP-1 derived from stromal keratocyte induces corneal infiltration of CD4+ T cells in herpetic stromal keratitisSun Kyoung Lee
The Immunomodulation Research Center, University of Ulsan, Ulsan 680 749, Korea
Mol Cells 26:67-73. 2008..We hypothesized that chemokines produced by stromal keratocytes are involved in CD4(+) T cell infiltration into the cornea...
- CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblastsXuefeng Yu
Department of Biology, Washington University, St Louis, MO 63130, USA
J Bone Miner Res 19:2065-77. 2004..Cytokines induced OB release of such chemokines, which may therefore significantly contribute to inflammatory bone loss.
- Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1-type immune responseTsunenori Kondo
Department of Urology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Cancer Sci 97:780-6. 2006The potential role of chemokines in clinical tumors remains poorly understood. Recent investigations have shown the differential expression of chemokine receptors on lymphocytes mediating Th1- and Th2-type immune responses...
- CHEMOKINE-MEDIATED NEUROPROTECTION AND REPAIR DURING WNV ENCEPHALITISROBYN SUE KLEIN; Fiscal Year: 2010The long term experimental objective of this competitive renewal is to evaluate the functional roles of chemokines and their receptors in contributing to viral clearance, immunopathology and repair in a murine model of WNV encephalitis...
- CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERSPhilip Osdoby; Fiscal Year: 2002..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
- ELR-CXC Chemokines In Lung Antibacterial Host DefenseTheodore Standiford; Fiscal Year: 2005..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
- IL-13 Associated Eosinophil Lung ResponsesMarc E Rothenberg; Fiscal Year: 2010..Extensive studies have also demonstrated a central role for chemokines in orchestrating multiple aspects of the asthmatic response...
- IL-13 Associated Eosinophil Lung ResponsesMARC ROTHENBERG; Fiscal Year: 2009..Extensive studies have also demonstrated a central role for chemokines in orchestrating multiple aspects of the asthmatic response...
- Viral Encephalitis, Chemokines and SleepLARRY D contact SANFORD; Fiscal Year: 2010..encephalitis, and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and cytokines in the brain...
- CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIVCatarina E Hioe; Fiscal Year: 2010..e. CC chemokines MIP-1a, MIP-1, and RANTES by the cells...
- MECHANISMS OF PULMONARY FIBROSISSem Phan; Fiscal Year: 2007..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
- Opioids,Cannabinoids,Chemokines:Neuroimmune InteractionsMartin Adler; Fiscal Year: 2006..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
- The Role of IL-17 Axis in Inflammatory MyositisANN M contact REED; Fiscal Year: 2010..and serum levels of the pro-inflammatory cytokine interleukin-17 (IL-17) and type-I interferon (IFN) regulated chemokines. Further, high levels of IL-17 and IFN-related chemokines are detected in muscle biopsies from both DM patients ..
- ROLE OF CHEMOKINES IN T CELL MEDIATED COLITISJames Lillard; Fiscal Year: 2002..b>Chemokines are a family of proteins that are resistant to inactivation by pH or proteolysis as well as affect the ..
- NF-kB Signaling in Osteoclastogenesis and Osteolytic Bone MetastasisCun Yu Wang; Fiscal Year: 2010..transcription factor which regulates a broad range of gene expression, including pro-inflammatory cytokines, chemokines and cell adhesion molecules...
- CXC CHEMOKINES AND LIVER REGENERATIONLisa Colletti; Fiscal Year: 2002..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
- Ras and Chemokine Stimulated Neutrophil PolarizationCindy Knall; Fiscal Year: 2004..The chemokines Interleukin-8 (IL8) and Growth-Regulated Oncogene alpha (GROalpha) control much of the normal function of ..
- Chemokines and T Cell Recruitment in High Risk Corneal Allograft RejectionVictor L Perez; Fiscal Year: 2010..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
- Chemokines and T Cell Recruitment in High Risk Corneal Allograft RejectionVictor L Perez; Fiscal Year: 2010..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
- The Role of C-C Chemokines in Eosinophil Airway InflammationNicholas Lukacs; Fiscal Year: 2009This competitive renewal will build upon our previous work on the role of chemokines and their receptors in airway inflammation...
- Regulation of Chemokine Mediated Leukocyte FunctionsMicheler Ricardo Richardson; Fiscal Year: 2010b>Chemokines are multifunctional mediators responsible for recruitment and activation of the leukocyte at the site of inflammation...
- CNS Pathobiology of IFN-inducible non-ELR CXC ChemokinesIain Campbell; Fiscal Year: 2007Three chemokines, CXCL9, CXCL10 and CXCL11, comprise the IFN-inducible non-ELR CXC chemokine subgroup...
- CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITISM Zink; Fiscal Year: 2003..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...