Genomes and Genes
Summary: Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Publications343 found, 100 shown here
- Chemokines: a new classification system and their role in immunityA Zlotnik
DNAX Research Institute, Palo Alto, California 94304, USA
Immunity 12:121-7. 2000
- Inflammation and cancerLisa M Coussens
Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
Nature 420:860-7. 2002..tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis...
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004....
- The many roles of chemokines and chemokine receptors in inflammationIsrael F Charo
Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
N Engl J Med 354:610-21. 2006
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptorY Feng
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
Science 272:872-7. 1996..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
- Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteriaFrank A W Verreck
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
Proc Natl Acad Sci U S A 101:4560-5. 2004..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
- Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesAlberto Mantovani
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
Trends Immunol 23:549-55. 2002..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
- Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxideGuangwen Ren
Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
Cell Stem Cell 2:141-50. 2008..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
- Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injuryJenna M Ziebell
National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, VIC 3181, Australia
Neurotherapeutics 7:22-30. 2010..This review addresses the role of several cytokines and chemokines following focal and diffuse TBI, as well as the controversies around the use of therapeutic anti-inflammatory ..
- A question of self-preservation: immunopathology in influenza virus infectionNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 85:85-92. 2007....
- Identification of a major co-receptor for primary isolates of HIV-1H Deng
Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
Nature 381:661-6. 1996..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
- Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networksBridgette D Semple
National Trauma Research Institute, Alfred Health, Melbourne, Victoria, Australia
J Cereb Blood Flow Metab 30:459-73. 2010b>Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of particular interest in the context of the unique immune responses elicited in the central nervous system (CNS)...
- Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusionYukihiko Suzuki
Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, Aomori, 036 8562, Japan
Jpn J Ophthalmol 55:256-63. 2011The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO)...
- Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiologyRichard M Ransohoff
Neuroinflammation Research Center Lerner Research Institute and Mellen Center for MS Treatment and Research Neurological Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Immunity 31:711-21. 2009There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology...
- The role of chemokine receptors in primary, effector, and memory immune responsesF Sallusto
Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
Annu Rev Immunol 18:593-620. 2000..There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic ..
- Chemokines and diseaseC Gerard
Department of Pediatrics, Perlmutter Laboratory, Children s Hospital, Boston, MA, USA
Nat Immunol 2:108-15. 2001..Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed...
- Chemokine receptors and their role in inflammation and infectious diseasesC Murdoch
Division of Child Health, University of Sheffield, Sheffield Children s Hospital, Sheffield, United Kingdom
Blood 95:3032-43. 2000b>Chemokines are small peptides that are potent activators and chemoattractants for leukocyte subpopulations and some nonhemopoietic cells...
- Alternative activation of macrophagesSiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 3:23-35. 2003..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
- The role of chemokines in neutrophil biologyYoshiro Kobayashi
Division of Molecular Medicine, Dept of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan
Front Biosci 13:2400-7. 2008..Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment...
- Chemokines and chemokine receptors: new insights into cancer-related inflammationGwendal Lazennec
INSERM, U844, Site Saint Eloi Bâtiment INM 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F 34090, France
Trends Mol Med 16:133-44. 2010b>Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation...
- Chemokines in liver inflammation and fibrosisHermann E Wasmuth
Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
Semin Liver Dis 30:215-25. 2010b>Chemokines are a class of small chemotactic molecules with cytokine-like functions, which are well known to orchestrate inflammatory responses within different organs. Overall, more than 50 ligands and 19 receptors belong to the network...
- Chemokines and their receptors: drug targets in immunity and inflammationAntonella Viola
Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
Annu Rev Pharmacol Toxicol 48:171-97. 2008..Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics...
- Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritisHeidi Kokkonen
Umea University Hospital, Umea, Sweden
Arthritis Rheum 62:383-91. 2010To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA).
- Orchestrating the orchestrators: chemokines in control of T cell trafficShannon K Bromley
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Nat Immunol 9:970-80. 2008The understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors have been identified...
- Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluidsValerie Wittamer
Institut de Recherche en Biologie Humaine et Moléculaire, ULB Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
J Exp Med 198:977-85. 2003..Therefore, chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs...
- Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescenceCoralie Martin
Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
Immunity 19:583-93. 2003..We show that the functional responses of freshly isolated human and murine neutrophils to CXCR2 chemokines are significantly attenuated by SDF-1alpha, acting via CXCR4...
- Chemerin is a novel adipokine associated with obesity and metabolic syndromeKiymet Bozaoglu
Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
Endocrinology 148:4687-94. 2007..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
- Chemokines in liver inflammation and fibrosisFabio Marra
Dipartimento di Medicina Interna, University of Florence, Italy
Front Biosci 7:d1899-914. 2002b>Chemokines may be involved in the tissue response to injury regulating the influx of leukocytes, and modulating a number of other critical biologic actions, including angiogenesis, neoplastic growth, myo-fibroblast activation, and the ..
- Molecular pathways linking inflammation and cancerA Mantovani
Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Curr Mol Med 10:369-73. 2010..Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
- Chemokine: receptor structure, interactions, and antagonismSamantha J Allen
Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, California 92093, USA
Annu Rev Immunol 25:787-820. 2007b>Chemokines are critical mediators of cell migration during routine immune surveillance, inflammation, and development...
- Cancer and the chemokine networkFran Balkwill
Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s Medical School, Charterhouse Square, London EC1M 6BQ, UK
Nat Rev Cancer 4:540-50. 2004
- Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous systemWilliam Rostene
Institut de la Vision UMRS INSERM UPMC 968, Paris, France
J Neurochem 118:680-94. 2011Recent observations suggest that besides their role in the immune system, chemokines have important functions in the brain...
- Chemokines: multiple levels of leukocyte migration controlBernhard Moser
Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
Trends Immunol 25:75-84. 2004The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to leukocyte traffic...
- Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitmentM Romano
Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
Immunity 6:315-25. 1997..to a reduced migratory capacity of IL-6-/- leukocytes and was associated with a reduced in situ production of chemokines. These observations led to a reexamination of the interaction of IL-6 with endothelial cells (EC)...
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Heon Park
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1133-41. 2005..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
- Characterization of chemokines and their receptors in the central nervous system: physiopathological implicationsAdriana Bajetto
Service of Pharmacology and Neuroscience Institute for Cancer Research, Genoa, Italy
J Neurochem 82:1311-29. 2002b>Chemokines represent key factors in the outburst of the immune response, by activating and directing the leukocyte traffic, both in lymphopoiesis and in immune surveillance...
- Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flowMika Shimonaka
Bayer Chair, Dept of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
J Cell Biol 161:417-27. 2003b>Chemokines arrest circulating lymphocytes within the vasculature through the rapid up-regulation of leukocyte integrin adhesive activity, promoting subsequent lymphocyte transmigration...
- Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolismKerry B Goralski
Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
J Biol Chem 282:28175-88. 2007..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
- The chemokine and chemokine receptor superfamilies and their molecular evolutionAlbert Zlotnik
Neurocrine Biosciences, Inc, Department of Molecular Medicine, 12790 El Camino Real, San Diego, CA 92130, USA
Genome Biol 7:243. 2006..This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human.
- Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokinesLaura Pelosi
Department of Histology and Medical Embryology, University of Rome La Sapienza, Via A Scarpa, 14 Rome 00161, Italy
FASEB J 21:1393-402. 2007..such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and modulated the expression of CC chemokines involved in the recruitment of monocytes/macrophages...
- The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaquesYichuan Wang
California National Primate Research Center, University of California Davis, Davis, California 95616, USA
J Virol 79:14355-70. 2005..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
- Chemokines in health and diseaseDayanidhi Raman
Department of Cancer Biology, Vanderbilt University, School of Medicine, USA
Exp Cell Res 317:575-89. 2011b>Chemokines and their receptors play a key role in development and homeostasis as well as in the pathogenesis of tumors and autoimmune diseases...
- Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout miceL Boring
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
J Clin Invest 100:2552-61. 1997..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
- Closed head injury--an inflammatory disease?Oliver I Schmidt
Department of Trauma and Reconstructive Surgery, Charité University Medical School Berlin, Campus Benjamin Franklin, Germany
Brain Res Brain Res Rev 48:388-99. 2005..the so far known mechanisms of posttraumatic neuroinflammation after CHI, based on data from clinical and experimental studies, with a special focus on the role of pro-inflammatory cytokines, chemokines, and the complement system.
- Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasisJaap G Neels
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 284:20692-8. 2009..These studies suggest that KC and its receptor CXCR2 are potential targets for the development of new therapeutic approaches for treatment of obesity-related insulin resistance, type II diabetes, and related cardiovascular diseases...
- Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseasesLaetitia Cartier
Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
Brain Res Brain Res Rev 48:16-42. 2005b>Chemokines were originally described as chemotactic cytokines involved in leukocyte trafficking. Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes...
- Antagonism of RANTES receptors reduces atherosclerotic plaque formation in miceNiels R Veillard
Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
Circ Res 94:253-61. 2004..Recruitment of leukocytes within the vascular wall, controlled by chemokines, is an essential process in the development of this common disease...
- Chemokines in atherosclerosis: an updateAlma Zernecke
Institute for Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Germany
Arterioscler Thromb Vasc Biol 28:1897-908. 2008The fundamental importance of chemokines for atherogenesis, progression, and destabilization of atherosclerotic plaques is now widely appreciated, but the degree of complexity, specificity, and cooperativity harnessed by these signal ..
- Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American populationKiymet Bozaoglu
Metabolic Research Unit, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3218, Australia
J Clin Endocrinol Metab 94:3085-8. 2009..Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in a small sample of subjects from Mauritius...
- Chemerin and its receptors in leukocyte trafficking, inflammation and metabolismBenjamin Bondue
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
Cytokine Growth Factor Rev 22:331-8. 2011..Both chemerin and ChemR23 are also expressed by adipocytes, and the emerging role of chemerin as an adipokine regulating lipid and carbohydrate metabolism is an area of intense research...
- Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expressionAmiram Ariel
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 7:1209-16. 2006..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesH Choe
Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cell 85:1135-48. 1996..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
- Natural hemozoin stimulates syncytiotrophoblast to secrete chemokines and recruit peripheral blood mononuclear cellsN W Lucchi
Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
Placenta 32:579-85. 2011....
- Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion moleculesJoão B Calixto
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina UFSC, Florianopolis, SC, Brazil
Planta Med 70:93-103. 2004..PK:protein kinase PMA/TPA:phorbol myristate acetate RANTES:regulated upon activation normal T-cell expressed and secreted TGF-beta:transforming growth factor-beta TNFalpha:tumour necrosis factor VCAM-1:vascular cell adhesion molecule-1..
- Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokinesNiels Halama
Medical Oncology, National Center for Tumor Diseases, University Heidelberg, Germany
Clin Cancer Res 17:678-89. 2011..The contribution of intratumoral cytokines and chemokines in shaping the composition of the inflammatory lymphocytic infiltrate is also unclear.
- The blood-brain barrier, chemokines and multiple sclerosisDavid W Holman
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Biochim Biophys Acta 1812:220-30. 2011..An important step in this cascade is the presence of chemokines on the vascular endothelial cell surface...
- The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophagesPaola Allavena
IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
Crit Rev Oncol Hematol 66:1-9. 2008..leukocyte infiltration; the expression of cytokines such as tumor necrosis factor (TNF) or interleukin (IL)-1; chemokines such as CCL2 and CXCL8; active tissue remodelling and neo-angiogenesis...
- Role of chemokines in regulation of immunity against leishmaniasisSteve Oghumu
Department of Pathology, The Ohio State University Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA
Exp Parasitol 126:389-96. 2010..immunity to Leishmania depends on recruitment of appropriate immune effector cells to the site of infection and chemokines play a crucial role in the process...
- Immunologic messenger molecules: cytokines, interferons, and chemokinesScott P Commins
University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
J Allergy Clin Immunol 125:S53-72. 2010Cytokines and chemokines are secreted proteins involved in numerous aspects of cell growth, differentiation, and activation...
- Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokinesM Anthony Moody
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
J Exp Med 207:763-76. 2010..The release of these beta-chemokines explains both the specificity for R5 HIV-1 and the activity of these mAbs in PBMC cultures containing both ..
- Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasisAna P Campanelli
Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
Hum Immunol 71:1220-7. 2010..Therefore, different chemokines may affect the predominance of cell infiltration in distinct clinical manifestations...
- The biology of chemokines and their receptorsD Rossi
PharMingen Inc, San Diego, California 92121 1111, USA
Annu Rev Immunol 18:217-42. 2000..of bioinformatics and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors...
- Immunology of tuberculosisJ L Flynn
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Annu Rev Immunol 19:93-129. 2001..the induction, specificity, and effector functions of CD4(+) and CD8(+) T cells, and the roles of cytokines and chemokines in the induction and effector functions of the immune response...
- Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesisJaspreet Kaur
Endocrinology and Metabolism Research Group, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
Biochem Biophys Res Commun 391:1762-8. 2010..01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity...
- Chemokines in the vascular inflammatory response of atherosclerosisAlma Zernecke
Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
Cardiovasc Res 86:192-201. 2010..In addition, the progression of atherosclerosis is determined by a disturbed equilibrium of immune responses. Chemokines and their receptors are instrumental in orchestrating the influx of leucocytes to the vascular wall, but also ..
- Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasisUwe Ritter
Nikolaus Fiebiger Zentrum für Molekulare Medizin, University of Erlangen Nurnberg, Erlangen, Germany
Parasite Immunol 24:295-301. 2002..Based on this evidence, we propose that tissue specific expression of these small molecules actively regulates cell traffic and tissue localization of effector cells and, additionally, has direct immunological effects...
- Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitmentMarkus Krumbholz
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
Brain 129:200-11. 2006..This study focused on the chemokines CXCL12 (SDF-1) and CXCL13 (BCA-1), both of which regulate B cell migration in lymphoid tissues...
- Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokinesBasam Z Barkho
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
Stem Cells 26:3139-49. 2008..Here we demonstrate that in response to two injury-induced chemokines, stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor, aNPCs differentiated into ..
- Chemokines regulate the migration of neural progenitors to sites of neuroinflammationAbdelhak Belmadani
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Neurosci 26:3182-91. 2006..slice cultures, grafted neural progenitor cells (NPs) migrate toward areas of neuroinflammation and that chemokines are a major regulator of this process...
- The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1E Oberlin
Unite d Immunologie Virale, Institut Pasteur, Paris, France
Nature 382:833-5. 1996..blood lymphocytes, SDF-1 is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains, whereas the CC chemokines RANTES, MIP-1 alpha and MIP-1 beta, which were shown previously to prevent infection with primary, monocyte-..
- Effect of posttranslational processing on the in vitro and in vivo activity of chemokinesAnneleen Mortier
Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Exp Cell Res 317:642-54. 2011..Hence, chemokines function in a complex network to mediate migration of the various leukocyte subsets, expressing specific GPCRs ..
- Experimental stroke induces massive, rapid activation of the peripheral immune systemHalina Offner
Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 26:654-65. 2006..We quantified mRNA and protein levels for cytokines, chemokines, and chemokine receptors (CCR) in brain, spinal cord, peripheral lymphoid organs (spleen, lymph node, blood, and ..
- Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic isletsValeria Sordi
Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, H S Raffaele Telethon Institute for Gene Therapy, and Renal Pathophysiology Laboratory, Division of Medicine, Via Olgettina 60, 20132 Milan, Italy
Blood 106:419-27. 2005..chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19...
- Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeletonPaul U Cameron
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
Proc Natl Acad Sci U S A 107:16934-9. 2010..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue...
- The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamilyL F Neville
XTL Biopharmaceuticals, Rehovot, Israel
Cytokine Growth Factor Rev 8:207-19. 1997..This paper aims to highlight our current knowledge of IP-10 and its homologues as well as defining its likely involvement in regulating fibroproliferation following inflammatory lung injury...
- RANTES: a versatile and controversial chemokineV Appay
Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK
Trends Immunol 22:83-7. 2001..RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans...
- HIV-1 infection and AIDS: consequences for the central nervous systemM Kaul
Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Death Differ 12:878-92. 2005..This review will discuss recently uncovered pathologic neuroimmune and degenerative mechanisms contributing to neuronal damage induced by HIV-1 and potential approaches for development of future therapeutic intervention...
- Chemerin, a novel adipokine in the regulation of angiogenesisKiymet Bozaoglu
Metabolic Research Unit, Deakin University, Geelong 3217, Australia
J Clin Endocrinol Metab 95:2476-85. 2010..Gene expression levels of chemerin were elevated in the adipose depots of obese compared with lean animals and was markedly elevated during differentiation of fibroblasts into mature adipocytes...
- Chemokines as mediators of neovascularizationEllen C Keeley
Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908 0466, USA
Arterioscler Thromb Vasc Biol 28:1928-36. 2008b>Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation...
- Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral stateSif Hansdottir
Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 1081, USA
J Immunol 184:965-74. 2010..Most importantly we found that, despite inducing IkappaBalpha and dampening chemokines and IFN-beta, there was no increase in viral mRNA or protein or in viral replication...
- Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathyEdecio Cunha-Neto
Laboratorio de Imunologia, Instituto do Coracao, Hospital das Clinicas, Sao Paulo, SP, Brasil
Mem Inst Oswaldo Cruz 104:252-8. 2009..In the last decade, increasing evidence has shown that inflammatory cytokines and chemokines play a role in the generation of the inflammatory infiltrate and tissue damage...
- Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virusTakashi Nakayama
Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
J Virol 78:1665-74. 2004b>Chemokines are likely to play important roles in the pathophysiology of diseases associated with Epstein-Barr virus (EBV). Here, we have analyzed the repertoire of chemokines expressed by EBV-infected B cells...
- Chemokines and pain mechanismsCatherine Abbadie
Department of Immunology, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
Brain Res Rev 60:125-34. 2009..two chemokine systems at the level of the dorsal root ganglia and spinal cord demonstrating that modulation of chemokines using selective antagonists decrease nociceptive behavior in rodent chronic pain models...
- Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary diseaseSun Ying
King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
J Immunol 181:2790-8. 2008..The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract them...
- The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionF Cocchi
Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
Nat Med 2:1244-7. 1996..The C-C chemokines RANTES, MIP-1 alpha and MIP-1 beta were recently identified as the major components of the HIV-SF produced by ..
- Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markersDietrich Rothenbacher
Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
Arterioscler Thromb Vasc Biol 26:194-9. 2006We investigated the association of several chemokines with the risk of stable coronary heart disease (CHD) in a large case-control study after adjustment for other established risk factors...
- Chemokines in host-parasite interactions in leishmaniasisMaria Jania Teixeira
Centro de Pesquisas Goncalo Moniz, FIOCRUZ, Rua Waldemar Falcao 121, 40295 001 Salvador, Bahia, Brazil
Trends Parasitol 22:32-40. 2006..Cell recruitment to the site of infection is essential to the development of the host cellular immune response. The process is controlled by chemokines, which are chemotactic cytokines produced by leukocytes and tissue cells.
- Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy womenEdward C Suarez
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3328, Durham, NC 27710, USA
Psychoneuroendocrinology 29:1119-28. 2004....
- The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokinesT Krakauer
Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
FEBS Lett 500:52-5. 2001..These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens...
- Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cellsTsvee Lapidot
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Exp Hematol 30:973-81. 2002..experimental animal models and samples from clinical mobilization protocols demonstrate major involvement of chemokines such as stromal derived factor-1 (SDF-1) and IL-8, as well as proteolytic enzymes such as elastase, cathepsin G, ..
- TLR4 activation mediates kidney ischemia/reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
J Clin Invest 117:2847-59. 2007..tubular damage, neutrophil and macrophage accumulation, and expression of proinflammatory cytokines and chemokines. In vitro, WT kidney TECs produced proinflammatory cytokines and chemokines and underwent apoptosis after ..
- Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion moleculesSusanne Herold
University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
J Immunol 177:1817-24. 2006....
- A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjectsIngrid Dahlman
Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden
J Clin Endocrinol Metab 90:5834-40. 2005..Low-grade inflammation in adipose tissue may contribute to insulin resistance in obesity. However, the roles of individual inflammatory mediators in adipose tissue are poorly understood...
- Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002C Herder
German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, 40225, Dusseldorf, Germany
Diabetologia 49:921-9. 2006The chemokines monocyte chemoattractant protein-1 (MCP-1), IL-8 and interferon-gamma-inducible protein-10 (IP-10) are released by adipocytes and appear to be involved in atherosclerosis...
- Chemokines and tuberculosisHolly M Scott Algood
Department of Molecular Genetics and Biochemistry and Molecular Virology and Microbiology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Cytokine Growth Factor Rev 14:467-77. 2003..The signals responsible for granuloma formation and maintenance are largely unknown. Since chemokines and chemokine receptors direct cells to specific sites within the tissues, it is plausible that these cells ..
- Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and CopaxoneJuliana Croitoru-Lamoury
Centre for Immunology, St Vincent s Hospital, Department of Neurology, Sydney NSW, Australia
J Interferon Cytokine Res 27:53-64. 2007..b>Chemokines are key mediators of selective cell migration in neurodegenerative diseases and related inflammatory processes...
- Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157)Vivian Berg
Department of Laboratory Medicine, University Hospital of North Norway, Sykehusveien 38, N 9038, Tromsø, Norway
Arthritis Res Ther 12:R228. 2010..In the present study, we aimed to clarify whether human chondrocytes express ChemR23 and chemerin, and whether chemerin/ChemR23 signalling could affect secretion of inflammatory mediators...
- Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositisHatice Bilgic
University of Minnesota, Minneapolis, MN 55455, USA
Arthritis Rheum 60:3436-46. 2009Up-regulation of whole blood type I interferon (IFN)-driven transcripts and chemokines has been described in a number of autoimmune diseases...
- Mediators of inflammation in acute kidney injuryAli Akcay
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80262, USA
Mediators Inflamm 2009:137072. 2009..The injury induces the generation of inflammatory mediators like cytokines and chemokines by tubular and endothelial cells which contribute to the recruiting of leukocytes into the kidneys...
- Chemokine receptor CCR5: from AIDS to atherosclerosisK L Jones
Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
Br J Pharmacol 162:1453-69. 2011There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease...
- Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skinWilliam Vermi
Department of Pathology, University of Brescia, 25123 Brescia, Italy
J Exp Med 201:509-15. 2005....
- CHEMOKINE-MEDIATED NEUROPROTECTION AND REPAIR DURING WNV ENCEPHALITISROBYN SUE KLEIN; Fiscal Year: 2010The long term experimental objective of this competitive renewal is to evaluate the functional roles of chemokines and their receptors in contributing to viral clearance, immunopathology and repair in a murine model of WNV encephalitis...
- CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERSPhilip Osdoby; Fiscal Year: 2002..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
- ELR-CXC Chemokines In Lung Antibacterial Host DefenseTheodore Standiford; Fiscal Year: 2005..While ELR-CXC chemokines have been shown to be expressed during the generation of Th1 cell-mediated immune responses against ..
- IL-13 Associated Eosinophil Lung ResponsesMARC ROTHENBERG; Fiscal Year: 2009..Extensive studies have also demonstrated a central role for chemokines in orchestrating multiple aspects of the asthmatic response...
- IL-13 Associated Eosinophil Lung ResponsesMarc E Rothenberg; Fiscal Year: 2010..Extensive studies have also demonstrated a central role for chemokines in orchestrating multiple aspects of the asthmatic response...
- Viral Encephalitis, Chemokines and SleepLARRY D contact SANFORD; Fiscal Year: 2010..encephalitis, and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and cytokines in the brain...
- CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIVCatarina E Hioe; Fiscal Year: 2010..e. CC chemokines MIP-1a, MIP-1, and RANTES by the cells...
- MECHANISMS OF PULMONARY FIBROSISSem Phan; Fiscal Year: 2007..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
- Opioids,Cannabinoids,Chemokines:Neuroimmune InteractionsMartin Adler; Fiscal Year: 2006..b>Chemokines, a subclass of cytokines, are produced by microglia in the brain...
- The Role of IL-17 Axis in Inflammatory MyositisANN M contact REED; Fiscal Year: 2010..and serum levels of the pro-inflammatory cytokine interleukin-17 (IL-17) and type-I interferon (IFN) regulated chemokines. Further, high levels of IL-17 and IFN-related chemokines are detected in muscle biopsies from both DM patients ..
- ROLE OF CHEMOKINES IN T CELL MEDIATED COLITISJames Lillard; Fiscal Year: 2002..b>Chemokines are a family of proteins that are resistant to inactivation by pH or proteolysis as well as affect the ..
- NF-kB Signaling in Osteoclastogenesis and Osteolytic Bone MetastasisCun Yu Wang; Fiscal Year: 2010..transcription factor which regulates a broad range of gene expression, including pro-inflammatory cytokines, chemokines and cell adhesion molecules...
- CXC CHEMOKINES AND LIVER REGENERATIONLisa Colletti; Fiscal Year: 2002..Inflammatory mediators, such as the CXC chemokines, are essential in the response to hepatic injury...
- Ras and Chemokine Stimulated Neutrophil PolarizationCindy Knall; Fiscal Year: 2004..The chemokines Interleukin-8 (IL8) and Growth-Regulated Oncogene alpha (GROalpha) control much of the normal function of ..
- Chemokines and T Cell Recruitment in High Risk Corneal Allograft RejectionVictor L Perez; Fiscal Year: 2010..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
- Chemokines and T Cell Recruitment in High Risk Corneal Allograft RejectionVictor L Perez; Fiscal Year: 2010..rejection of solid vascularized organ allotransplants have shown that the early induction of selective chemokines at the site of transplantation after surgery is required for the optimal recruitment of T cells into rejecting ..
- The Role of C-C Chemokines in Eosinophil Airway InflammationNicholas Lukacs; Fiscal Year: 2009This competitive renewal will build upon our previous work on the role of chemokines and their receptors in airway inflammation...
- Regulation of Chemokine Mediated Leukocyte FunctionsMicheler Ricardo Richardson; Fiscal Year: 2010b>Chemokines are multifunctional mediators responsible for recruitment and activation of the leukocyte at the site of inflammation...
- CNS Pathobiology of IFN-inducible non-ELR CXC ChemokinesIain Campbell; Fiscal Year: 2007Three chemokines, CXCL9, CXCL10 and CXCL11, comprise the IFN-inducible non-ELR CXC chemokine subgroup...
- CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITISM Zink; Fiscal Year: 2003..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...