transforming growth factors


Summary: Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.

Top Publications

  1. ncbi Transforming growth factors (TGF-alpha and TGF-beta1) in the determination of vitality and wound age: immunohistochemical study on human skin wounds
    W Grellner
    Institute of Forensic Medicine, University of Mainz, Am Pulverturm 3, D 55131 Mainz, Germany
    Forensic Sci Int 153:174-80. 2005
  2. ncbi The phosphodiesterase inhibitor, pentoxifylline, alters rat intestinal epithelial cell proliferation via changes in the expression of transforming growth factors
    M Diab-Assef
    INSERM U381, Strasbourg, France
    Scand J Gastroenterol 37:206-14. 2002
  3. ncbi Expression of transforming growth factors in hepatocellular carcinoma and its relations with clinicopathological parameters and prognosis
    Yun Lu
    Department of Hepatobiliary Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
    Hepatobiliary Pancreat Dis Int 7:174-8. 2008
  4. pmc The prognostic significance of transforming growth factors in human breast cancer
    P A Murray
    Department of Medical Oncology, St Georges Hospital, London, UK
    Br J Cancer 67:1408-12. 1993
  5. ncbi Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family
    D E Barton
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Oncogene Res 3:323-31. 1988
  6. ncbi Postnatal changes in testicular concentrations of transforming growth factors-alpha and-beta 1, 2 and 3 and serum concentrations of insulin like growth factor I in bulls
    E T Bagu
    Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    Reprod Domest Anim 45:348-53. 2010
  7. pmc Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells
    A J Ridley
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 109:3419-24. 1989
  8. pmc Transcripts for transforming growth factors in human breast cancer: clinical correlates
    P Barrett Lee
    Medical Oncology Unit, St George s Hospital Medical School, London, UK
    Br J Cancer 61:612-7. 1990
  9. ncbi CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint
    Sergey Doronkin
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley 94720, USA
    Development 129:5053-64. 2002
  10. pmc Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis
    A Norvell
    Howard Hughes Medical Insitute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA
    Genes Dev 13:864-76. 1999

Detail Information

Publications250 found, 100 shown here

  1. ncbi Transforming growth factors (TGF-alpha and TGF-beta1) in the determination of vitality and wound age: immunohistochemical study on human skin wounds
    W Grellner
    Institute of Forensic Medicine, University of Mainz, Am Pulverturm 3, D 55131 Mainz, Germany
    Forensic Sci Int 153:174-80. 2005
    ..of former investigations on proinflammatory cytokines, in the present study the relevance of the transforming growth factors TGF-alpha and TGF-beta1 was evaluated for the diagnosis of vitality and wound age...
  2. ncbi The phosphodiesterase inhibitor, pentoxifylline, alters rat intestinal epithelial cell proliferation via changes in the expression of transforming growth factors
    M Diab-Assef
    INSERM U381, Strasbourg, France
    Scand J Gastroenterol 37:206-14. 2002
  3. ncbi Expression of transforming growth factors in hepatocellular carcinoma and its relations with clinicopathological parameters and prognosis
    Yun Lu
    Department of Hepatobiliary Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
    Hepatobiliary Pancreat Dis Int 7:174-8. 2008
    b>Transforming growth factors (TGF)-beta1, TGF-betaR2 and Smad4 belong to the TGF family, and play important roles in carcinogenesis and the development of carcinoma, especially hepatocellular carcinoma (HCC)...
  4. pmc The prognostic significance of transforming growth factors in human breast cancer
    P A Murray
    Department of Medical Oncology, St Georges Hospital, London, UK
    Br J Cancer 67:1408-12. 1993
    ..018). EGFR levels did not predict for early relapse or survival. TGF alpha mRNA levels were measured in 104 patients, no correlation was seen tumour size, node status, Er status, or clinical outcome...
  5. ncbi Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family
    D E Barton
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Oncogene Res 3:323-31. 1988
  6. ncbi Postnatal changes in testicular concentrations of transforming growth factors-alpha and-beta 1, 2 and 3 and serum concentrations of insulin like growth factor I in bulls
    E T Bagu
    Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    Reprod Domest Anim 45:348-53. 2010
    Based on work largely in laboratory animals, transforming growth factors (TGF) and insulin like growth factors (IGF) could be regulators of testicular development...
  7. pmc Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells
    A J Ridley
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 109:3419-24. 1989
    ..Thus, TGF-beta 1 and beta 2 are rat Schwann cell mitogens, and Schwann cells are one of the few normal cell populations to respond mitogenically to TGF-beta...
  8. pmc Transcripts for transforming growth factors in human breast cancer: clinical correlates
    P Barrett Lee
    Medical Oncology Unit, St George s Hospital Medical School, London, UK
    Br J Cancer 61:612-7. 1990
    The levels of mRNA for transforming growth factors (TGF alpha and beta) and the epidermal growth factor receptor (EGFR) were determined in 69 human breast carcinomas and 20 biopsies of non-neoplastic breast tissue by dot blot ..
  9. ncbi CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint
    Sergey Doronkin
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley 94720, USA
    Development 129:5053-64. 2002
    ..They also reveal a link between DNA repair, axis formation and the COP9 signalosome, a protein complex that acts in multiple signaling pathways by regulating protein stability...
  10. pmc Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis
    A Norvell
    Howard Hughes Medical Insitute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA
    Genes Dev 13:864-76. 1999
    ..These results demonstrate the isoform-specific contributions of individual hnRNP proteins in the regulation of a specific mRNA. Moreover, these data suggest a novel role for hnRNPs in localization and translational regulation of mRNAs...
  11. ncbi vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development
    S Styhler
    Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1, Canada
    Development 125:1569-78. 1998
    ..However, GRK accumulation in the oocyte is severely reduced in the absence of vasa function, suggesting a function for VASA in activating gurken translation in wild-type ovaries...
  12. pmc Characterization of differentially expressed genes in purified Drosophila follicle cells: toward a general strategy for cell type-specific developmental analysis
    Z Bryant
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:5559-64. 1999
  13. ncbi Local Gurken signaling and dynamic MAPK activation during Drosophila oogenesis
    F Peri
    Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35 II, 72076, Tubingen, Germany
    Mech Dev 81:75-88. 1999
    ..Instead they are specified by secondary signal amplification and refinement processes that integrate the Gurken signal with positive and negative feedback mechanisms generated by target genes of the DER pathway...
  14. pmc The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development
    M Suzanne
    Centre de Biologie du Developpement, UMR5547 Centre National de la Recherche Scientifique CNRS, 31062 Toulouse Cedex, France
    Genes Dev 13:1464-74. 1999
    ..These results provide the first genetic demonstration of an essential function for a p38 pathway during development...
  15. ncbi Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila
    Francesca Peri
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstr 17, D 50923 Köln, Germany
    Development 129:2965-75. 2002
    ..This indicates that potent inhibitory processes prevent pipe dependent Toll activation at the dorsal side of the egg...
  16. ncbi Differential expression of the Drosophila zinc finger gene jim in the follicular epithelium
    H Doerflinger
    Institut Jacques Monod, Equipe de Biologie du Développement, UMR 7592, CNRS and Universités Denis Diderot Paris 7 and Paris 6 Pierre et Marie Curie, 2 place Jussieu, F 75251, Paris Cedex 05, France
    Mech Dev 86:177-82. 1999
    ..From stage 10A onward, jim-1 RNA is transcribed in squamous cells while jim-2 RNA is specific to all non-antero-dorsal columnar cells as the result of repression in antero-dorsal cells by the DER pathway...
  17. ncbi The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in Drosophila
    A M Queenan
    HHMI, Department of Molecular Biology, Princeton University, Princeton 08544, USA
    Mech Dev 89:35-42. 1999
    ..We conclude that secretion of Gurken requires its transmembrane region, and propose a model in which the gene cornichon mediates this process...
  18. ncbi The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis
    C Ghiglione
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:847-56. 1999
    ..We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism...
  19. ncbi A novel follicle-cell-dependent dominant female sterile allele, StarKojak, alters receptor tyrosine kinase signaling in Drosophila
    D M Ruden
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, 66045, USA
    Dev Biol 207:393-407. 1999
    ..We propose that Star functions by processing pro-Gurken to mature Gurken, which is thereby released in the region between the oocyte and the follicle cells and binds to the epidermal growth factor receptor in the follicle cells...
  20. ncbi Requirement for the vasa RNA helicase in gurken mRNA localization
    R Tinker
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Dev Biol 199:1-10. 1998
  21. ncbi Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids
    Sinisa Urban
    MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    Curr Biol 12:1507-12. 2002
    ..Moreover, a function for Rhomboids in activating intercellular signaling appears to have evolved early...
  22. ncbi Twin peaks: Spitz and Argos star in patterning of the Drosophila egg
    L Stevens
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell 95:291-4. 1998
  23. ncbi Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis
    A González-Reyes
    The Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Development 125:2837-46. 1998
    ..Finally, we show that Notch plays a role in both the specification and patterning of the terminal follicle cells, providing a possible explanation for the defect in anterior-posterior axis formation caused by Notch and Delta mutants...
  24. ncbi An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg
    J D Wasserman
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 95:355-64. 1998
    ..This sequential activation, amplification, and local inhibition of the EGFR forms an autoregulatory cascade that leads to the splitting of an initial single peak of signaling into two, thereby patterning the egg...
  25. ncbi Oocyte polarity depends on regulation of gurken by Vasa
    P Tomancak
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 125:1723-32. 1998
    ..A variety of early oogenesis phenotypes observed in vasa ovaries, which cannot be attributed to the defect in gurken expression, suggest that vasa also affects expression of other mRNAs...
  26. pmc A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands
    Sinisa Urban
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 21:4277-86. 2002
    ..This is distinct from the metalloprotease-induced activation of mammalian EGF-like ligands...
  27. ncbi The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization
    C Saunders
    Department of Molecular Biosciences, University of Kansas, Lawrence 66045, USA
    Mol Cell 3:43-54. 1999
    ..We also show that gurken mRNA and protein localization is dependent on region-specific translation of gurken transcripts and identify K10 as a probable negative regulator of gurken translation...
  28. ncbi Developmental biology. Sending all the right signals
    N Perrimon
    Nature 396:18-9. 1998
  29. ncbi Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs
    D Zhao
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, UK
    Dev Genet 25:375-86. 1999
  30. ncbi Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary
    L L Dobens
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Development 127:745-54. 2000
    ..Thus, the balance of DPP and EGF signals sets the boundary of bunched expression. We propose that the juxtaposition of cells with high and low BUNCHED activity organizes a sharp boundary for the operculum fate...
  31. ncbi RNA localization and translational regulation during axis specification in the Drosophila oocyte
    R L Cooperstock
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Int Rev Cytol 203:541-66. 2001
    ..We then discuss the generality of these mechanisms during oogenesis by focusing on a second transcript, oskar, whose function is also regulated through a combination of transcript localization and translational control...
  32. pmc Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity
    A M Volpe
    Department of Genetics, University of Washington, Seattle, Washington 98195 7360, USA
    Genetics 159:1117-34. 2001
    ..These functions may involve direct binding of Rhi to chromosomes or may involve indirect effects on pathways controlling these processes...
  33. ncbi Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte
    N MacDougall
    Wellcome Centre for Cell Biology, ICMB, King s Buildings, University of Edinburgh, Edinburgh EH9 3JR, UK
    Development 128:665-73. 2001
    ..We propose that Merlin acts in response to the Gurken signal by apically targeting the signal that initiates axis specification in the oocyte...
  34. ncbi Functioning of the Drosophila orb gene in gurken mRNA localization and translation
    J S Chang
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Development 128:3169-77. 2001
    ..Finally, we present evidence that Orb protein expression during the mid- to late stages of oogenesis is, in turn, negatively regulated by K(10)...
  35. ncbi The Mirror transcription factor links signalling pathways in Drosophila oogenesis
    D Zhao
    Roslin Institute, Roslin, Midlothian EH10 4AN, UK
    Dev Genes Evol 210:449-57. 2000
    ..This coordination is required for epithelial morphogenesis, and for producing the signal in ventral follicle cells that determines the dorsal/ventral axis of the embryo...
  36. ncbi A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila
    K Guillemin
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Nat Cell Biol 3:848-51. 2001
    ..The requirement of a nuclear lamin for cytoplasmic as well as nuclear organization has important implications for both the cellular functions of lamins and the pathogenesis of human diseases caused by lamin mutations...
  37. pmc Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis
    H Lopez-Schier
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 15:1393-405. 2001
    ..The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control...
  38. ncbi Stable anterior anchoring of the oocyte nucleus is required to establish dorsoventral polarity of the Drosophila egg
    A Guichet
    Universitat zu Koln, Institut fur Entwicklungsbiologie, Gyrhofstrasse 17, Cologne, 50923, Germany
    Dev Biol 237:93-106. 2001
    ..cap 'n' collar mutants, therefore, allow for the study of the influence of Grk signal duration on DV patterning in the follicular epithelium...
  39. ncbi The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping
    S Pathirana
    Institute of Cell and Molecular Biology, University of Edinburgh, EH9 3JR, Edinburgh, UK
    Mech Dev 109:137-50. 2001
  40. ncbi D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis
    L M Pai
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Cell 103:51-61. 2000
    ..In addition, Egfr activity has to be repressed through the activity of D-cbl to ensure the absence of signaling in the ventral most follicle cells...
  41. ncbi Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis
    C Van Buskirk
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton NJ 08544, USA princeton edu
    Development 127:4753-62. 2000
    ..We argue that the enc mutant phenotypes reflect a role for Enc in the regulation of several RNA targets...
  42. ncbi Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg
    F Peri
    Institut fur Entwicklungsbiologie, Universitat zu Koln, D 50923 Köln, Germany
    Development 127:841-50. 2000
    ..This intersection also induces rhomboid expression and thereby initiates the positive feedback loop of EGF receptor activation, which positions the dorsal appendages along the dorsal-ventral egg axis...
  43. ncbi Gurken, a TGF-alpha-like protein involved in axis determination in Drosophila, directly binds to the EGF-receptor homolog Egfr
    Anat Shmueli
    Department of Molecular Genetics of Development, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochem Biophys Res Commun 291:732-7. 2002
    ..Furthermore, we provide evidence that this characteristic motif may be sufficient for interaction with the receptor, at list in vitro. Our results firmly establish Gurken as the germline ligand of Drosophila Egfr...
  44. ncbi Localization of gurken RNA in Drosophila oogenesis requires elements in the 5' and 3' regions of the transcript
    G L Thio
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA
    Dev Biol 221:435-46. 2000
    ..Active translation is not required for localization of the grk RNA. The mechanism of gurken RNA localization, therefore, differs from that of other localized RNAs studied to date...
  45. ncbi Desensitization of cannabinoid-mediated presynaptic inhibition of neurotransmission between rat hippocampal neurons in culture
    Maria Kouznetsova
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Pharmacol 61:477-85. 2002
  46. ncbi A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis
    D L Myster
    Department of Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Development 127:3249-61. 2000
    ..Thus we have uncovered new functions for E2F transcription factors during development, including an unexpected role in pattern formation...
  47. ncbi sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo
    H Araujo
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA
    Development 127:3631-44. 2000
    ..These results broaden the role previously defined for sog and dpp in establishing the embryonic DV axis and reveal a novel form of crossregulation between the NF(kappa)B and TGF(beta) signaling pathways in pattern formation...
  48. ncbi brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling
    A Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Dev Biol 226:255-66. 2000
    ..We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium...
  49. ncbi Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells
    D Zhao
    The University of Edinburgh, Institute of Cell and Molecular Biology, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    J Cell Sci 113:3781-94. 2000
    ..This has been confirmed by re-examination of fng mutants and analysis of fng mutant clones in oogenesis...
  50. ncbi Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo
    D Morisato
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Development 128:2309-19. 2001
    ..The production of two Dorsal peaks is addressed by a model that invokes action of a diffusible inhibitor, which is proposed to normally regulate the slope of the Dorsal gradient...
  51. ncbi Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes
    A González-Reyes
    The Wellcome CRC Institute and Department of Genetics, University of Cambridge, UK
    Development 124:4927-37. 1997
    ..Thus, these mutants reveal a novel link between oocyte selection, oocyte positioning and axis formation in Drosophila, leading us to propose that the spindle genes act in a process that is common to several of these events...
  52. ncbi Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: Growth factor and Ras signaling pathways
    Herbert B Newton
    Dardinger Neuro oncology Center, Department of Neurology, Ohio State University Hospitals, Columbus 43210, USA
    Expert Rev Anticancer Ther 3:595-614. 2003
    ..Further development of targeted therapies and evaluation of these new agents in clinical trials will be needed to improve survival and quality of life of patients with brain tumors...
  53. ncbi [Neurotrophic factor expression in vestibular schwannoma. An overview]
    M Diensthuber
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Laryngorhinootologie 85:731-7. 2006
    ..In this article, we summarize the findings on neurotrophic factor expression and discuss their characteristics and biological role in vestibular schwannoma...
  54. ncbi mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila
    P A Newmark
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
    Development 124:3197-207. 1997
    ..In the absence of mago+ function during oogenesis, the anteroposterior and dorsoventral coordinates of the oocyte are not specified and the germ plasm fails to assemble...
  55. pmc Translational repressor bruno plays multiple roles in development and is widely conserved
    P J Webster
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Genes Dev 11:2510-21. 1997
    ..Bru belongs to an evolutionarily conserved family of genes, suggesting that Bru-mediated translational regulation may be widespread. Models for the molecular mechanism of Bru function are discussed...
  56. ncbi Dorsoventral patterning in Drosophila oogenesis
    T Schupbach
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Curr Opin Genet Dev 4:502-7. 1994
    ..This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo...
  57. pmc The origin of dorsoventral polarity in Drosophila
    Siegfried Roth
    Institut fur Entwicklungsbiologie, Universitat Koln, Gyrhofstrasse 17, 50923 Koln, Germany
    Philos Trans R Soc Lond B Biol Sci 358:1317-29; discussion 1329. 2003
    ..This leads to a nuclear concentration gradient of Dorsal that specifies the cell types along the DV axis of the embryo...
  58. ncbi Polarization of both major body axes in Drosophila by gurken-torpedo signalling
    A González-Reyes
    Wellcome CRC Institute, University of Cambridge, UK
    Nature 375:654-8. 1995
    ..As the gurken-torpedo/DER pathway also establishes dorsoventral polarity later in oogenesis, Drosophila uses the same germline to soma signalling pathway to determine both embryonic axes...
  59. ncbi Double FISH and FISH-fluorescence immunolocalization procedures for whole-mount Drosophila ovaries
    C Saunders
    Department of Biochemistry, Cell and Molecular Biology, University of Kansas, Lawrence 66045, USA
    Biotechniques 26:186-8. 1999
  60. ncbi The Drosophila TGF-alpha-like protein Gurken: expression and cellular localization during Drosophila oogenesis
    F S Neuman-Silberberg
    HHMI, Department of Molecular Biology, Princeton University, NJ 08544, USA
    Mech Dev 59:105-13. 1996
    ..By immunoblotting we detect one major form of the Gurken protein, which likely corresponds to the unprocessed protein...
  61. ncbi Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors
    Marc Alexander Brockmann
    Hans Dietrich Herrmann Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neurosurgery 52:1391-9; discussion 1399. 2003
    ..Several growth factors are thought to be involved in glioma cell migration; however, little is known about their motogenic potency relative to one another...
  62. ncbi Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis
    W M Deng
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Development 124:4639-47. 1997
  63. ncbi maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA
    N J Clegg
    Department of Biochemistry, University of Washington, Seattle 98195 7350, USA
    Development 124:4661-71. 1997
    ..The maelstrom gene encodes a novel protein that has a punctate distribution in the cytoplasm of the nurse cells and the oocyte until the protein disappears in stage 7 of oogenesis...
  64. ncbi One signal, two body axes
    K Anderson
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Science 269:489-90. 1995
  65. ncbi Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis
    A Sapir
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 125:191-200. 1998
    ..Rho thus appears to be involved in processing a DER ligand in the follicle cells, to pattern the egg chamber and allow persistent activation of the DER pathway during formation of the dorsal appendages...
  66. ncbi Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila
    N C Hawkins
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, NJ 08544, USA
    Development 124:4801-10. 1997
    ..We present evidence that enc regulates Grk post-transcriptionally to ensure adequate levels of signaling for establishment of the anterior-posterior and dorsal-ventral axes...
  67. ncbi Why do anal wounds heal adequately? A study of the local immunoinflammatory defense mechanisms
    Pedro Roberto de Paula
    Departamento de Medicina, Universidade de Taubate, Taubate, Brazil
    Dis Colon Rectum 47:1861-7. 2004
    ..The aim of this study was to identify the tissue defense immunoinflammatory mechanisms present in the healing process of anal region wounds resulting from hemorrhoidectomy by the open technique...
  68. ncbi Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repai
    James Melrose
    Raymond Purves Bone and Joint Research Laboratories, Institute of Bone and Joint Research, University of Sydney, Australia
    Spine (Phila Pa 1976) 27:1756-64. 2002
    ..The spatial and temporal localization of fibroblast growth factor-2, transforming growth factor-beta, osteonectin, and alpha-smooth muscle cell actin in the injured anulus fibrosus was investigated...
  69. ncbi Effect of prenatal tetrandrine administration on transforming growth factor-beta1 level in the lung of nitrofen-induced congenital diaphragmatic hernia rat model
    Chang Xu
    Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China
    J Pediatr Surg 44:1611-20. 2009
    ..The aim of this study was to evaluate the effect of prenatal administration of Tet and to investigate its possible mechanism on the expression of TGF-beta1 in the lung of nitrofen-induced CDH rat model...
  70. ncbi [The effect of intrapleural pingyangmycin administration on activity of fibrinolytic system and transforming growth factor-beta1 in malignant pleural effusion]
    Qing Qing Zhu
    Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:674-8. 2009
  71. ncbi The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-beta1
    Andor Hirschberg
    Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Laryngoscope 113:120-4. 2003
    ..The study was designed to examine the suggested roles of IgE, interleukin-5 (IL-5), and transforming growth factor-beta1 (TGF-beta1) in the pathogenesis of nasal polyposis...
  72. ncbi Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques
    Y J Ma
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 97006
    Neuroendocrinology 60:346-59. 1994
    ..abstract truncated at 400 words)..
  73. ncbi Modulation of collagen gene expression by cytokines: stimulatory effect of transforming growth factor-beta1, with divergent effects of epidermal growth factor and tumor necrosis factor-alpha on collagen type I and collagen type IV
    J P Grande
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    J Lab Clin Med 130:476-86. 1997
  74. ncbi Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor
    M Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL 60612, USA
    Med Oncol 18:121-30. 2001
    ..In summary, even at relatively low oligo concentrations and short exposure, oligos against TGF-alpha, and particularly EGFR, significantly inhibit in vitro growth of the T98G glioblastoma, possibly mediated by decreased EGFR expression...
  75. ncbi Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 188:76-83. 2003
    ..We also studied the mitogenic effects of transforming growth factor-beta1 and platelet derived growth factor on myometrial and leiomyoma cells in culture...
  76. ncbi Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice
    H C Su
    Division of Biology and Medicine, Brown University, Providence, RI 02912
    J Immunol 151:4874-90. 1993
    ..Treatment with active TGF-beta 1 reduced the numbers of NK cells per spleen in infected nude mice to the levels found in infected littermate controls.(ABSTRACT TRUNCATED AT 400 WORDS)..
  77. ncbi Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)
    N Duneas
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Growth Factors 15:259-77. 1998
    ..The present findings may provide the basis for synergistic molecular therapeutics for cartilage and bone regeneration in clinical contexts...
  78. ncbi Expression of transforming growth factor-beta isoforms (beta 2 and beta 3) in the mouse uterus: analysis of the periimplantation period and effects of ovarian steroids
    S K Das
    Department of Obstetrics Gynecology, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City 66160 7338
    Endocrinology 130:3459-66. 1992
    ..In comparison, neither an injection of E2 nor one of P4 exerted significant effects on TGF beta 3 mRNA levels.(ABSTRACT TRUNCATED AT 400 WORDS)..
  79. ncbi Enhanced tumorigenesis and reduced transforming growth factor-beta type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-beta1
    Y Kang
    Medicine Branch, National Cancer Institute, Rockville, Maryland 20850, USA
    Mol Carcinog 29:112-26. 2000
  80. ncbi Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys
    D Bosukonda
    Creative BioMolecules, Inc, Hopkinton, Massachusetts, USA
    Kidney Int 58:1902-11. 2000
    ..The molecular events involved in OP-1 action on kidney are not yet understood...
  81. ncbi Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene
    K Nishida
    Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA
    Spine (Phila Pa 1976) 24:2419-25. 1999
    ..Gene therapy therefore may have useful applications for study of the basic science of the intervertebral disc and for clinical management of degenerative disc disease...
  82. ncbi Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
    Dev Dyn 211:11-25. 1998
    ..We present an epigenetic model of information processing related to cell proliferation. The model is a dynamical network that uses continuous logic to learn its rules from changing conditions...
  83. ncbi Expression of transforming growth factor-alpha and epidermal growth factor receptor mRNA in the gastric mucosa of portal hypertensive rats
    Jan Sing Hsieh
    Department of Surgery, Kaohsiung Medical University Hospital, No 100, Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Hepatogastroenterology 50:1305-10. 2003
  84. ncbi Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes
    P E Poleni
    Laboratoire de Physiopathologie et Pharmacologie Articulaires LPPA, UMR 7561 CNRS UHP Nancy 1, avenue de la Forêt de Haye, BP 184, 54505 Vandoeuvre Les Nancy Cedex, France
    Osteoarthritis Cartilage 15:493-505. 2007
  85. ncbi Coordinate regulation by diethylstilbestrol of the platelet-derived growth factor-A (PDGF-A) and -B chains and the PDGF receptor alpha- and beta-subunits in the mouse uterus and vagina: potential mediators of estrogen action
    K Gray
    Laboratory of Developmental and Reproductive Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 136:2325-40. 1995
    ..After DES treatment, the uterus exhibits a significant decrease in the level of PDGF ligand and receptor proteins immunostained within 6 h, whereas less dramatic effects ar observed in the vagina.(ABSTRACT TRUNCATED AT 400 WORDS)..
  86. ncbi Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cells
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
    Am J Obstet Gynecol 189:1620-5; discussion 1625-6. 2003
  87. ncbi Role of interleukin-10 and transforming growth factor beta 1 in otitis media with effusion
    Shou Qin Zhao
    Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing 100730, China
    Chin Med J (Engl) 122:2149-54. 2009
  88. ncbi The effect of transforming growth factor beta1 (TGF-beta1) on the regenerate bone in distraction osteogenesis
    Korhan Ozkan
    Department of Orthopedics and Traumatology, Goztepe Education and Research Hospital, Istanbul, Turkey
    Growth Factors 25:101-7. 2007
    ..Most probably, type 1 receptors are up-regulated by this exogenous administration, but unfortunately, there is currently no specific stain on tha market to display type 1 receptors and to prove this explanation...
  89. ncbi Comparison of the antisecretory and antiulcer activity of epidermal growth factor, urogastrone and transforming growth factor alpha and its derivative in rodents in vivo
    S M A Bastaki
    Department of Pharmacology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain
    Mol Cell Biochem 236:83-94. 2002
    ..The present study also suggests that EGF, UG and TGFalpha are equally effective against AE-induced gastric ulcer and bring about their cytoprotective action through their reduction of acid secretion and through PG and NO pathways...
  90. ncbi Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis
    Bin Bin Zhang
    Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
    World J Gastroenterol 9:2490-6. 2003
    ..To determine whether these factors or enzymes could be used as the indices for the diagnosis of hepatic fibrosis, we investigated them by means of receiver operating characteristic (ROC) curve...
  91. pmc Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene
    Henrik Karring
    Center for Insoluble Protein Structures, Department of Molecular Biology, Science Park, University of Aarhus, Aarhus C, Denmark
    Mol Vis 13:997-1004. 2007
    ..Therefore, we investigated the specificity of the originally utilized anti-p68(beta ig-h3) antiserum and re-evaluated the amount of TGFBIp in human plasma by immunoblotting using a new specific antiserum...
  92. ncbi Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis
    Agostino Molteni
    Department of Pathology and Basic Medicinal Science, University of Missouri at Kansas City, Truman Medical Center, Kansas City, MO 64108, USA
    Curr Pharm Des 13:1307-16. 2007
  93. ncbi [The role of transforming growth factor-beta1/Smad3 signaling in bronchiolitis obliterans following lung transplantation]
    Hong Xu Liu
    Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 87:2069-73. 2007
    ..To investigate the mechanism underlying bronchiolitis obliterans (OB) following lung transplantation and the significance of transforming growth factor (TGF)-beta1/Smad3 signal pathway in this pathological process...
  94. ncbi Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation
    C E Rube
    Department of Radiooncology, University of Munster, Munster, Germany
    Int J Radiat Oncol Biol Phys 47:1033-42. 2000
    ..The purpose of this investigation was to evaluate the acute and long-term effects of radiation on the gene expression of transforming growth factor beta (TGF-beta) in a model of lung injury using fibrosis-sensitive C57BL/6 mice...
  95. ncbi Regulation of transforming growth factor-beta1 expression by granulocyte macrophage-colony-stimulating factor in leiomyoma and myometrial smooth muscle cells
    N Chegini
    Department of Obstetrics and Gynecology, University of Florida, Gainesville 32610, USA
    J Clin Endocrinol Metab 84:4138-43. 1999
  96. ncbi [Effect on transforming growth factor-beta1 of glucocorticoid-induced avascular necrosis of femoral head in rats by treatment of activating blood circulation of Chinese herbal medicine]
    Zhen xi Qi
    Department of Technological Industry, Fujian TCM College, Fuzhou 350003, Fujian, China
    Zhongguo Gu Shang 22:596-8. 2009
    ..To interpret the mechanism of the effect on Steroid-avascular necrosis of femoral head by activating blood circulation,and offer a effective method to clinical...
  97. ncbi Differential expression of transforming growth factor-alpha and macrophage colony-stimulating factor/colony-stimulating factor-1R (c-fins) by multinucleated giant cells involved in pathological bone resorption at the site of orthopaedic implants
    N Al-Saffar
    Department of Histopathology, Royal Free and University College Medical School, Hampstead, London, England
    J Orthop Res 18:800-7. 2000
  98. ncbi Increased release of transforming growth factor (TGF)-beta1, TGF-beta2, and chemoattractant mediators in pneumonia
    F Buhling
    Institute of Immunology, Otto von Guericke University Magdeburg, Germany
    J Interferon Cytokine Res 19:271-8. 1999
    ..42 nmol/L). Our results strongly suggest that different lung diseases do differ with regard to the released cytokines. TGF-beta1 probably plays a key role in regulation of pulmonary inflammation, particularly in pneumonia...
  99. ncbi A transforming growth factor-beta1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura
    P O Andersson
    Department of Internal Medicine, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Ann Hematol 79:507-13. 2000
    ..We propose that the effect of possible expression of TGF-beta1 by oral immune tolerance induction deserves to be explored in ITP patients with an active disease...
  100. ncbi Biodegradable chitosan scaffolds containing microspheres as carriers for controlled transforming growth factor-beta1 delivery for cartilage tissue engineering
    Dao Zhang Cai
    Department of Orthopedics, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
    Chin Med J (Engl) 120:197-203. 2007
    ..In this study, we assessed the feasibility of using biodegradable chitosan microspheres as carriers for controlled TGF-beta1 delivery and the effect of released TGF-beta1 on the chondrogenic potential of chondrocytes...
  101. pmc Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils
    M A Gibson
    Department of Pathology, University of Adelaide, South Australia
    Mol Cell Biol 15:6932-42. 1995
    ..Thus, LTBP-2 appears to share functional characteristics with both LTBP-1 and fibrillins...

Research Grants70

  1. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..The outcome of this project will be the initial characterization of a valuable therapeutic option for treatment of patients with various types of skin wounds. ..
  2. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA). ..
    Melanie H Cobb; Fiscal Year: 2012
    ..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
  4. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..We will also determine how the native bone protein spp24 (secreted phosphoprotein-24 kDa) inhibits BMP/TGF-b-dependent tumor cell growth. ..
  5. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
  6. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..Germline mutations of the type II BMP receptor (BMPRII) gene are associated with IPAH. By studying a protein called FHL2 that interacts with BMPRII and regulates BMPRII function, this application will investigate the etiology of IPAH. ..
  7. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..The in vitro and in vivo results will be valuable for glaucoma therapy as well as in treatments for other ocular disorders related to scarring, such as proliferative vitreoretinopathy. ..
  8. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..Completion of this work will provide insight into the pathogenesis of BPD, lead to the development of more accurate biomarkers, and provide new information on the role of matricellular proteins in lung fibrosis. ..
  9. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
  10. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
  11. Hepatocyte Nox proteins in the pathogenesis of hepatocellular carcinoma
    Jinah Choi; Fiscal Year: 2013
    ..Results from this study will increase our understanding of hepatocyte Nox4 and the role of inflammation in cancer, for the development of therapy. ..
  12. Periostin Regulation of Lung Fibrosis
    Bethany B Moore; Fiscal Year: 2013
    ..via which periostin and TGFb regulate each other and the function of lung mesenchymal cells Aim 4) To determine whether periostin levels in plasma or bronchoalveolar lavage fluid of IPF patients correlate with disease progression ..
    Namasivayam Ambalavanan; Fiscal Year: 2012
  14. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..End of Abstract) ..
  15. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..The models could afford the opportunity to delineate the molecular and cellular mechanisms of cardiolaminopathy and shed light into the mechanisms of cardiovascular senescence. ..
  16. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..The information resulting from these investigations has a potential to provide clues to how HCV-induced oxidative stress and calcium signaling may induce profibrogenic factor, TGF-21, liver fibrosis and ultimately liver cancer. ..
  17. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..Our studies will provide crucial information about GTPBPs which may eventually translate into clinical treatments for diseases caused by abnormal TGF[unreadable] or GTPBP signaling. ..
  18. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..This proposal addresses the mechanisms by which DC-TLR responses are altered during viral infections and thus has the potential to provide novel therapeutic strategies to fight-off opportunistic pathogens associated with viral diseases. ..
  19. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..To address these issues, we will use prematurely delivered rabbit pups as an experimental animal and will also use autopsy materials from premature infants with and without brain hemorrhage. ..
    Kevin E Behrns; Fiscal Year: 2010
    ..3) To determine if cirrhotic human hepatocytes are resistant to TGFbeta-induced apoptosis via mechanisms that are operative in a murine model. ..
  21. Innate immunity in dermal fibrosis and systemic sclerosis
    ROBERT A LAFYATIS; Fiscal Year: 2013
  22. TGF-Beta in Intimal Hyperplasia after Vascular Bypass
    K Craig Kent; Fiscal Year: 2013
    ..The long-term goal is to develop specific therapies that prevent or halt the progression of arterial restenosis, thus reducing morbidity and mortality for thousands of individuals each year. ..
  23. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2013
  24. Cellular Senescence and Glaucoma
    Pedro Gonzalez; Fiscal Year: 2011
  25. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2013
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    Mario Chojkier; Fiscal Year: 2012
    ..These studies are relevant to the hepatocyte proliferation and survival characteristic of many physiological and pathological conditions, including hepatocellular injury, liver regeneration and hepatocellular carcinoma. ..
  28. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..This research will elucidate the role of tooth/bone matrix material properties in oral and skeletal health and disease. ..
  29. The Impact of Oxidative Stress on HIV-induced Lung Disease
    Jesse Roman; Fiscal Year: 2013
    ..If found to be causal, Eh Cys/CySS and nAChRs can be targeted for intervention in the hope of reducing the incidence and/or severity of HIV-related non-infectious lung disease. ..
  30. Role of Bone Morphogenetic Protein 4 in Hypoxic Pulmomary Hypertension
    Jian Wang; Fiscal Year: 2013
    ..Our study focuses on investigation of whether and how BMP4 regulates this process, which, if successful, will lead to improved methods of pharmacological prevention and treatment of this lethal complication of chronic lung diseases. ..
  31. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..Targeted gene therapy delivered to the cornea with a simple topical technique offers promise to cure, treat and/or prevent vision loss by modulating excessive healing mechanisms that cause these blinding corneal disorders. ..
  32. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
  33. Role of trabecular meshwork contractility in modulating outflow resistance
    CHEE HIAN TAN; Fiscal Year: 2013
    ..This project studies a potential mechanism for regulating intraocular pressure that can help us better understand glaucoma and ways to treat it. ..
  34. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
  35. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..We will assess the impact of delivery of let-7g pre-miRNA on HDM-induced remodeling. ..
  36. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
    ..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
  37. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..This study will investigate the function of recently discovered sulfatase enzymes that enhance growth of liver cancers, with the goal of developing effective treatments for this devastating disease. ..
  38. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
  39. Effects of Alcohol on Stem Cells in the Adult Brain
    Michael W Miller; Fiscal Year: 2012
    ..Such data are of key importance for our understanding of other neurodegenerative diseases (e.g., Alzheimer's and Parkinson's Diseases) and for the developmental of therapeutic strategies to address these diseases. ..
  40. Smooth Muscle Differentiation and Maturation
    Shiyou Chen; Fiscal Year: 2013
    ..Our proposal examining the molecular mechanisms that regulate smooth muscle differentiation should help to identify therapeutic targets for the treatment of these diseases. ..
  41. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..Early treatment can be targeted to at-risk, genetically susceptible individuals to offset the consequences of pathogenic mutations and prevent disease progression. ..
    Nikhil C Munshi; Fiscal Year: 2013
    ..The proposed studies will identify the mechanism of immune suppression in myeloma, develop methods to improve immune function and develop peptide-based vaccination strategies to preclinical rational for their clinical application. ..
    Michael W Miller; Fiscal Year: 2010
  44. Systems analysis of TGFbeta signaling and SnoN function in liver
    Kunxin Luo; Fiscal Year: 2013
    ..The long-term goal of this project is to understand how proper levels of TGF2 signaling activity are maintained and regulated in normal tissues and primary cells using a system biology approach. ..
  45. Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic Aneurysms
    Jeffrey A Jones; Fiscal Year: 2013
    Sem H Phan; Fiscal Year: 2010
    ..several key cytokines with fibrogenic activities, including monocyte chemotactic protein-1 (MCP-1), transforming growth factors a (TGFa) and (}(TGFp)...
  47. Mechanisms of Antifibrotic Actions of Relaxin in the Liver
    Robert G Bennett; Fiscal Year: 2013
    ..The research proposed in this application may lead to targeted therapeutic strategies for the treatment of liver disease, a major health concern in the United States. ..
  48. Investigations of the optimum serum bicarbonate level in renal disease
    KALANI LUKELA RAPHAEL; Fiscal Year: 2013
    ..With continued supervision by my mentors and by being at an institution with the resources and dedication to facilitate the development of young faculty members, I am confident that I will be successful. ..
  49. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
  50. Human Milk Factor Protection in Neonatal Necrotizing Enterocolitis
    Sheng Ru Shiou; Fiscal Year: 2012
    ..This proposal will investigate how Epo and TGF-b protect immature intestine, in order to develop a treatment to prevent or ameliorate NEC in vulnerable infants. ..
  51. Angiotensin-II, Hypothalamic Inflammation and Neurogenic Hypertension
    ANNETTE DIANE DE KLOET; Fiscal Year: 2012
    ..This is of particular relevance to public health because uncovering the mechanisms of Ang-II regulation of inflammation and cardiovascular function may lead to new strategies for the treatment and prevention of hypertension. ..
  52. Control of Colonic Inflammation and Tumor Growth by TGFBeta and Dietary Vitamin D
    Lillian Maggio-Price; Fiscal Year: 2012
    ..The detailed understanding of dietary effects and molecular mechanisms will permit more targeted and effective therapies for treatment of these diseases. ..
  53. TGF beta-induced apoptosis in B-lymphocytes
    Philip H Howe; Fiscal Year: 2013
    ..Our research may identify factors and important regulatory pathways that could be used therapeutically to modulate Bim expression in vivo. ..
  54. Retinoids and Hyperoxic Lung Injury
    Masheika L James; Fiscal Year: 2012
    ..abstract_text> ..
  55. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2011
    ..The goal of this study is to improve implant biocompatibility with host tissue by elucidating the role of mesenchymal stem cells in TGF-?[unreadable] dependent fibrous tissue formation. ..
  56. Myostatin Regulation of Skeletal Muscle Energy Metabolism
    SUZANNE PORSZASZ-REISZ; Fiscal Year: 2013
    ..This study will focus on Mst function in adulthood and will enhance our understanding of the regulatory role of Mst and may additionally provide insight into the treatment of muscle loss and metabolic syndrome. ..
  57. microRNA regulatory function in Leiomyoma growth
    Xiaoping Luo; Fiscal Year: 2010
    ..This proposal will investigate how fibroids grow and ways to prevent their symptoms and growth. ..
  58. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Susan J Zieman; Fiscal Year: 2012
    Frank A Middleton; Fiscal Year: 2013
    ..In concert, the novel Aims will use three complementary models to gain critical insight into mechanisms defining cell proliferation and fate and the effects of ethanol on these critical factors. ..
  60. Mechanisms of RelA Activation in Cancer
    Paul J Chiao; Fiscal Year: 2013
    ..Most importantly, this study may discover novel molecular targets for improving the treatment for pancreatic cancer. ..
  61. Regulatory Mechanisms of Implant-Induced Osteolysis
    Yousef Abu-Amer; Fiscal Year: 2013
    ..Our proposal addresses novel questions and holds promise to identify novel selective anti-osteolytic therapies. ..
  62. Ac-SDKP for Treatment of Acute Stroke
    Zheng Gang Zhang; Fiscal Year: 2013
    ..These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke. ..
  63. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..If this treatment proves to be safe and effective, it will be the first "cure" for diabetic retinopathy. ..
    STEVEN KINCAID; Fiscal Year: 1991
    ..The results will establish the capacity of HA/TGF-B to sustain proteoglycan syntheses to facilitate repair of osteoarthritic articular cartilage...
  65. FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung Cance
    Feng Ming Kong; Fiscal Year: 2009
    ..If successful, future radiation therapy could be personalized based on their response to radiation and treatment gain could be maximized. ..
  66. Trafficking of BMP signals in neurons
    Guillermo Marques; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  67. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Health implications: New treatments to prevent diabetic kidney disease, the most important cause of kidney failure in the US, may emerge from a better understanding of a naturally protected state such as the prepubertal animal. ..
    Michael Skinner; Fiscal Year: 2007
    ..e. cord formation) that transforming growth factors (i.e...
    Michael Skinner; Fiscal Year: 2000
    ..Observations are anticipated to provide insight into the molecular and cellular control of ovarian physiology. ..
  70. Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem Cells
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..Our focus is to demonstrate proof of principle that adult HSC can be effectively used to repair infarcted coronary vessels and eventually greatly improve the quality and duration of these patient's lives. ..