Genomes and Genes
transforming growth factors
Summary: Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.
Publications250 found, 100 shown here
- Transforming growth factors (TGF-alpha and TGF-beta1) in the determination of vitality and wound age: immunohistochemical study on human skin woundsW Grellner
Institute of Forensic Medicine, University of Mainz, Am Pulverturm 3, D 55131 Mainz, Germany
Forensic Sci Int 153:174-80. 2005..of former investigations on proinflammatory cytokines, in the present study the relevance of the transforming growth factors TGF-alpha and TGF-beta1 was evaluated for the diagnosis of vitality and wound age...
- The phosphodiesterase inhibitor, pentoxifylline, alters rat intestinal epithelial cell proliferation via changes in the expression of transforming growth factorsM Diab-Assef
INSERM U381, Strasbourg, France
Scand J Gastroenterol 37:206-14. 2002....
- Expression of transforming growth factors in hepatocellular carcinoma and its relations with clinicopathological parameters and prognosisYun Lu
Department of Hepatobiliary Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Hepatobiliary Pancreat Dis Int 7:174-8. 2008b>Transforming growth factors (TGF)-beta1, TGF-betaR2 and Smad4 belong to the TGF family, and play important roles in carcinogenesis and the development of carcinoma, especially hepatocellular carcinoma (HCC)...
- The prognostic significance of transforming growth factors in human breast cancerP A Murray
Department of Medical Oncology, St Georges Hospital, London, UK
Br J Cancer 67:1408-12. 1993..018). EGFR levels did not predict for early relapse or survival. TGF alpha mRNA levels were measured in 104 patients, no correlation was seen tumour size, node status, Er status, or clinical outcome...
- Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene familyD E Barton
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
Oncogene Res 3:323-31. 1988....
- Postnatal changes in testicular concentrations of transforming growth factors-alpha and-beta 1, 2 and 3 and serum concentrations of insulin like growth factor I in bullsE T Bagu
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
Reprod Domest Anim 45:348-53. 2010Based on work largely in laboratory animals, transforming growth factors (TGF) and insulin like growth factors (IGF) could be regulators of testicular development...
- Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cellsA J Ridley
Imperial Cancer Research Fund, London, United Kingdom
J Cell Biol 109:3419-24. 1989..Thus, TGF-beta 1 and beta 2 are rat Schwann cell mitogens, and Schwann cells are one of the few normal cell populations to respond mitogenically to TGF-beta...
- Transcripts for transforming growth factors in human breast cancer: clinical correlatesP Barrett Lee
Medical Oncology Unit, St George s Hospital Medical School, London, UK
Br J Cancer 61:612-7. 1990The levels of mRNA for transforming growth factors (TGF alpha and beta) and the epidermal growth factor receptor (EGFR) were determined in 69 human breast carcinomas and 20 biopsies of non-neoplastic breast tissue by dot blot ..
- CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpointSergey Doronkin
Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley 94720, USA
Development 129:5053-64. 2002..They also reveal a link between DNA repair, axis formation and the COP9 signalosome, a protein complex that acts in multiple signaling pathways by regulating protein stability...
- Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesisA Norvell
Howard Hughes Medical Insitute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA
Genes Dev 13:864-76. 1999..These results demonstrate the isoform-specific contributions of individual hnRNP proteins in the regulation of a specific mRNA. Moreover, these data suggest a novel role for hnRNPs in localization and translational regulation of mRNAs...
- vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst developmentS Styhler
Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1, Canada
Development 125:1569-78. 1998..However, GRK accumulation in the oocyte is severely reduced in the absence of vasa function, suggesting a function for VASA in activating gurken translation in wild-type ovaries...
- Characterization of differentially expressed genes in purified Drosophila follicle cells: toward a general strategy for cell type-specific developmental analysisZ Bryant
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 96:5559-64. 1999....
- Local Gurken signaling and dynamic MAPK activation during Drosophila oogenesisF Peri
Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35 II, 72076, Tubingen, Germany
Mech Dev 81:75-88. 1999..Instead they are specified by secondary signal amplification and refinement processes that integrate the Gurken signal with positive and negative feedback mechanisms generated by target genes of the DER pathway...
- The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric developmentM Suzanne
Centre de Biologie du Developpement, UMR5547 Centre National de la Recherche Scientifique CNRS, 31062 Toulouse Cedex, France
Genes Dev 13:1464-74. 1999..These results provide the first genetic demonstration of an essential function for a p38 pathway during development...
- Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in DrosophilaFrancesca Peri
Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstr 17, D 50923 Köln, Germany
Development 129:2965-75. 2002..This indicates that potent inhibitory processes prevent pipe dependent Toll activation at the dorsal side of the egg...
- Differential expression of the Drosophila zinc finger gene jim in the follicular epitheliumH Doerflinger
Institut Jacques Monod, Equipe de Biologie du Développement, UMR 7592, CNRS and Universités Denis Diderot Paris 7 and Paris 6 Pierre et Marie Curie, 2 place Jussieu, F 75251, Paris Cedex 05, France
Mech Dev 86:177-82. 1999..From stage 10A onward, jim-1 RNA is transcribed in squamous cells while jim-2 RNA is specific to all non-antero-dorsal columnar cells as the result of repression in antero-dorsal cells by the DER pathway...
- The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in DrosophilaA M Queenan
HHMI, Department of Molecular Biology, Princeton University, Princeton 08544, USA
Mech Dev 89:35-42. 1999..We conclude that secretion of Gurken requires its transmembrane region, and propose a model in which the gene cornichon mediates this process...
- The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesisC Ghiglione
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 96:847-56. 1999..We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism...
- A novel follicle-cell-dependent dominant female sterile allele, StarKojak, alters receptor tyrosine kinase signaling in DrosophilaD M Ruden
Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, 66045, USA
Dev Biol 207:393-407. 1999..We propose that Star functions by processing pro-Gurken to mature Gurken, which is thereby released in the region between the oocyte and the follicle cells and binds to the epidermal growth factor receptor in the follicle cells...
- Requirement for the vasa RNA helicase in gurken mRNA localizationR Tinker
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
Dev Biol 199:1-10. 1998....
- Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboidsSinisa Urban
MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
Curr Biol 12:1507-12. 2002..Moreover, a function for Rhomboids in activating intercellular signaling appears to have evolved early...
- Twin peaks: Spitz and Argos star in patterning of the Drosophila eggL Stevens
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell 95:291-4. 1998
- Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesisA González-Reyes
The Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
Development 125:2837-46. 1998..Finally, we show that Notch plays a role in both the specification and patterning of the terminal follicle cells, providing a possible explanation for the defect in anterior-posterior axis formation caused by Notch and Delta mutants...
- An autoregulatory cascade of EGF receptor signaling patterns the Drosophila eggJ D Wasserman
MRC Laboratory of Molecular Biology, Cambridge, England
Cell 95:355-64. 1998..This sequential activation, amplification, and local inhibition of the EGFR forms an autoregulatory cascade that leads to the splitting of an initial single peak of signaling into two, thereby patterning the egg...
- Oocyte polarity depends on regulation of gurken by VasaP Tomancak
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Development 125:1723-32. 1998..A variety of early oogenesis phenotypes observed in vasa ovaries, which cannot be attributed to the defect in gurken expression, suggest that vasa also affects expression of other mRNAs...
- A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligandsSinisa Urban
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
EMBO J 21:4277-86. 2002..This is distinct from the metalloprotease-induced activation of mammalian EGF-like ligands...
- The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localizationC Saunders
Department of Molecular Biosciences, University of Kansas, Lawrence 66045, USA
Mol Cell 3:43-54. 1999..We also show that gurken mRNA and protein localization is dependent on region-specific translation of gurken transcripts and identify K10 as a probable negative regulator of gurken translation...
- Developmental biology. Sending all the right signalsN Perrimon
Nature 396:18-9. 1998
- Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggsD Zhao
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, UK
Dev Genet 25:375-86. 1999....
- Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundaryL L Dobens
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Development 127:745-54. 2000..Thus, the balance of DPP and EGF signals sets the boundary of bunched expression. We propose that the juxtaposition of cells with high and low BUNCHED activity organizes a sharp boundary for the operculum fate...
- RNA localization and translational regulation during axis specification in the Drosophila oocyteR L Cooperstock
Program in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Int Rev Cytol 203:541-66. 2001..We then discuss the generality of these mechanisms during oogenesis by focusing on a second transcript, oskar, whose function is also regulated through a combination of transcript localization and translational control...
- Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarityA M Volpe
Department of Genetics, University of Washington, Seattle, Washington 98195 7360, USA
Genetics 159:1117-34. 2001..These functions may involve direct binding of Rhi to chromosomes or may involve indirect effects on pathways controlling these processes...
- Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyteN MacDougall
Wellcome Centre for Cell Biology, ICMB, King s Buildings, University of Edinburgh, Edinburgh EH9 3JR, UK
Development 128:665-73. 2001..We propose that Merlin acts in response to the Gurken signal by apically targeting the signal that initiates axis specification in the oocyte...
- Functioning of the Drosophila orb gene in gurken mRNA localization and translationJ S Chang
Department of Molecular Biology, Princeton University, NJ 08544, USA
Development 128:3169-77. 2001..Finally, we present evidence that Orb protein expression during the mid- to late stages of oogenesis is, in turn, negatively regulated by K(10)...
- The Mirror transcription factor links signalling pathways in Drosophila oogenesisD Zhao
Roslin Institute, Roslin, Midlothian EH10 4AN, UK
Dev Genes Evol 210:449-57. 2000..This coordination is required for epithelial morphogenesis, and for producing the signal in ventral follicle cells that determines the dorsal/ventral axis of the embryo...
- A nuclear lamin is required for cytoplasmic organization and egg polarity in DrosophilaK Guillemin
Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
Nat Cell Biol 3:848-51. 2001..The requirement of a nuclear lamin for cytoplasmic as well as nuclear organization has important implications for both the cellular functions of lamins and the pathogenesis of human diseases caused by lamin mutations...
- Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesisH Lopez-Schier
Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
Genes Dev 15:1393-405. 2001..The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control...
- Stable anterior anchoring of the oocyte nucleus is required to establish dorsoventral polarity of the Drosophila eggA Guichet
Universitat zu Koln, Institut fur Entwicklungsbiologie, Gyrhofstrasse 17, Cologne, 50923, Germany
Dev Biol 237:93-106. 2001..cap 'n' collar mutants, therefore, allow for the study of the influence of Grk signal duration on DV patterning in the follicular epithelium...
- The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumpingS Pathirana
Institute of Cell and Molecular Biology, University of Edinburgh, EH9 3JR, Edinburgh, UK
Mech Dev 109:137-50. 2001....
- D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesisL M Pai
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Cell 103:51-61. 2000..In addition, Egfr activity has to be repressed through the activity of D-cbl to ensure the absence of signaling in the ventral most follicle cells...
- Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesisC Van Buskirk
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton NJ 08544, USA princeton edu
Development 127:4753-62. 2000..We argue that the enc mutant phenotypes reflect a role for Enc in the regulation of several RNA targets...
- Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila eggF Peri
Institut fur Entwicklungsbiologie, Universitat zu Koln, D 50923 Köln, Germany
Development 127:841-50. 2000..This intersection also induces rhomboid expression and thereby initiates the positive feedback loop of EGF receptor activation, which positions the dorsal appendages along the dorsal-ventral egg axis...
- Gurken, a TGF-alpha-like protein involved in axis determination in Drosophila, directly binds to the EGF-receptor homolog EgfrAnat Shmueli
Department of Molecular Genetics of Development, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Biochem Biophys Res Commun 291:732-7. 2002..Furthermore, we provide evidence that this characteristic motif may be sufficient for interaction with the receptor, at list in vitro. Our results firmly establish Gurken as the germline ligand of Drosophila Egfr...
- Localization of gurken RNA in Drosophila oogenesis requires elements in the 5' and 3' regions of the transcriptG L Thio
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA
Dev Biol 221:435-46. 2000..Active translation is not required for localization of the grk RNA. The mechanism of gurken RNA localization, therefore, differs from that of other localized RNAs studied to date...
- Desensitization of cannabinoid-mediated presynaptic inhibition of neurotransmission between rat hippocampal neurons in cultureMaria Kouznetsova
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Mol Pharmacol 61:477-85. 2002....
- A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesisD L Myster
Department of Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Development 127:3249-61. 2000..Thus we have uncovered new functions for E2F transcription factors during development, including an unexpected role in pattern formation...
- sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryoH Araujo
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA
Development 127:3631-44. 2000..These results broaden the role previously defined for sog and dpp in establishing the embryonic DV axis and reveal a novel form of crossregulation between the NF(kappa)B and TGF(beta) signaling pathways in pattern formation...
- brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signalingA Guichard
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
Dev Biol 226:255-66. 2000..We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium...
- Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cellsD Zhao
The University of Edinburgh, Institute of Cell and Molecular Biology, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
J Cell Sci 113:3781-94. 2000..This has been confirmed by re-examination of fng mutants and analysis of fng mutant clones in oogenesis...
- Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryoD Morisato
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Development 128:2309-19. 2001..The production of two Dorsal peaks is addressed by a model that invokes action of a diffusible inhibitor, which is proposed to normally regulate the slope of the Dorsal gradient...
- Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genesA González-Reyes
The Wellcome CRC Institute and Department of Genetics, University of Cambridge, UK
Development 124:4927-37. 1997..Thus, these mutants reveal a novel link between oocyte selection, oocyte positioning and axis formation in Drosophila, leading us to propose that the spindle genes act in a process that is common to several of these events...
- Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: Growth factor and Ras signaling pathwaysHerbert B Newton
Dardinger Neuro oncology Center, Department of Neurology, Ohio State University Hospitals, Columbus 43210, USA
Expert Rev Anticancer Ther 3:595-614. 2003..Further development of targeted therapies and evaluation of these new agents in clinical trials will be needed to improve survival and quality of life of patients with brain tumors...
- [Neurotrophic factor expression in vestibular schwannoma. An overview]M Diensthuber
Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
Laryngorhinootologie 85:731-7. 2006..In this article, we summarize the findings on neurotrophic factor expression and discuss their characteristics and biological role in vestibular schwannoma...
- mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in DrosophilaP A Newmark
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
Development 124:3197-207. 1997..In the absence of mago+ function during oogenesis, the anteroposterior and dorsoventral coordinates of the oocyte are not specified and the germ plasm fails to assemble...
- Translational repressor bruno plays multiple roles in development and is widely conservedP J Webster
Department of Biological Sciences, Stanford University, California 94305 5020, USA
Genes Dev 11:2510-21. 1997..Bru belongs to an evolutionarily conserved family of genes, suggesting that Bru-mediated translational regulation may be widespread. Models for the molecular mechanism of Bru function are discussed...
- Dorsoventral patterning in Drosophila oogenesisT Schupbach
Department of Molecular Biology, Princeton University, New Jersey 08544
Curr Opin Genet Dev 4:502-7. 1994..This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo...
- The origin of dorsoventral polarity in DrosophilaSiegfried Roth
Institut fur Entwicklungsbiologie, Universitat Koln, Gyrhofstrasse 17, 50923 Koln, Germany
Philos Trans R Soc Lond B Biol Sci 358:1317-29; discussion 1329. 2003..This leads to a nuclear concentration gradient of Dorsal that specifies the cell types along the DV axis of the embryo...
- Polarization of both major body axes in Drosophila by gurken-torpedo signallingA González-Reyes
Wellcome CRC Institute, University of Cambridge, UK
Nature 375:654-8. 1995..As the gurken-torpedo/DER pathway also establishes dorsoventral polarity later in oogenesis, Drosophila uses the same germline to soma signalling pathway to determine both embryonic axes...
- Double FISH and FISH-fluorescence immunolocalization procedures for whole-mount Drosophila ovariesC Saunders
Department of Biochemistry, Cell and Molecular Biology, University of Kansas, Lawrence 66045, USA
Biotechniques 26:186-8. 1999
- The Drosophila TGF-alpha-like protein Gurken: expression and cellular localization during Drosophila oogenesisF S Neuman-Silberberg
HHMI, Department of Molecular Biology, Princeton University, NJ 08544, USA
Mech Dev 59:105-13. 1996..By immunoblotting we detect one major form of the Gurken protein, which likely corresponds to the unprocessed protein...
- Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factorsMarc Alexander Brockmann
Hans Dietrich Herrmann Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Neurosurgery 52:1391-9; discussion 1399. 2003..Several growth factors are thought to be involved in glioma cell migration; however, little is known about their motogenic potency relative to one another...
- Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesisW M Deng
Institute of Cell and Molecular Biology, University of Edinburgh, UK
Development 124:4639-47. 1997....
- maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNAN J Clegg
Department of Biochemistry, University of Washington, Seattle 98195 7350, USA
Development 124:4661-71. 1997..The maelstrom gene encodes a novel protein that has a punctate distribution in the cytoplasm of the nurse cells and the oocyte until the protein disappears in stage 7 of oogenesis...
- One signal, two body axesK Anderson
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
Science 269:489-90. 1995
- Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axisA Sapir
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Development 125:191-200. 1998..Rho thus appears to be involved in processing a DER ligand in the follicle cells, to pattern the egg chamber and allow persistent activation of the DER pathway during formation of the dorsal appendages...
- Post-transcriptional regulation of gurken by encore is required for axis determination in DrosophilaN C Hawkins
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, NJ 08544, USA
Development 124:4801-10. 1997..We present evidence that enc regulates Grk post-transcriptionally to ensure adequate levels of signaling for establishment of the anterior-posterior and dorsal-ventral axes...
- Why do anal wounds heal adequately? A study of the local immunoinflammatory defense mechanismsPedro Roberto de Paula
Departamento de Medicina, Universidade de Taubate, Taubate, Brazil
Dis Colon Rectum 47:1861-7. 2004..The aim of this study was to identify the tissue defense immunoinflammatory mechanisms present in the healing process of anal region wounds resulting from hemorrhoidectomy by the open technique...
- Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repaiJames Melrose
Raymond Purves Bone and Joint Research Laboratories, Institute of Bone and Joint Research, University of Sydney, Australia
Spine (Phila Pa 1976) 27:1756-64. 2002..The spatial and temporal localization of fibroblast growth factor-2, transforming growth factor-beta, osteonectin, and alpha-smooth muscle cell actin in the injured anulus fibrosus was investigated...
- Effect of prenatal tetrandrine administration on transforming growth factor-beta1 level in the lung of nitrofen-induced congenital diaphragmatic hernia rat modelChang Xu
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China
J Pediatr Surg 44:1611-20. 2009..The aim of this study was to evaluate the effect of prenatal administration of Tet and to investigate its possible mechanism on the expression of TGF-beta1 in the lung of nitrofen-induced CDH rat model...
- [The effect of intrapleural pingyangmycin administration on activity of fibrinolytic system and transforming growth factor-beta1 in malignant pleural effusion]Qing Qing Zhu
Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Zhonghua Jie He He Hu Xi Za Zhi 32:674-8. 2009....
- The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-beta1Andor Hirschberg
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Laryngoscope 113:120-4. 2003..The study was designed to examine the suggested roles of IgE, interleukin-5 (IL-5), and transforming growth factor-beta1 (TGF-beta1) in the pathogenesis of nasal polyposis...
- Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaquesY J Ma
Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 97006
Neuroendocrinology 60:346-59. 1994..abstract truncated at 400 words)..
- Modulation of collagen gene expression by cytokines: stimulatory effect of transforming growth factor-beta1, with divergent effects of epidermal growth factor and tumor necrosis factor-alpha on collagen type I and collagen type IVJ P Grande
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
J Lab Clin Med 130:476-86. 1997....
- Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptorM Rubenstein
Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL 60612, USA
Med Oncol 18:121-30. 2001..In summary, even at relatively low oligo concentrations and short exposure, oligos against TGF-alpha, and particularly EGFR, significantly inhibit in vitro growth of the T98G glioblastoma, possibly mediated by decreased EGFR expression...
- Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyomaAydin Arici
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Obstet Gynecol 188:76-83. 2003..We also studied the mitogenic effects of transforming growth factor-beta1 and platelet derived growth factor on myometrial and leiomyoma cells in culture...
- Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID miceH C Su
Division of Biology and Medicine, Brown University, Providence, RI 02912
J Immunol 151:4874-90. 1993..Treatment with active TGF-beta 1 reduced the numbers of NK cells per spleen in infected nude mice to the levels found in infected littermate controls.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)N Duneas
Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
Growth Factors 15:259-77. 1998..The present findings may provide the basis for synergistic molecular therapeutics for cartilage and bone regeneration in clinical contexts...
- Expression of transforming growth factor-beta isoforms (beta 2 and beta 3) in the mouse uterus: analysis of the periimplantation period and effects of ovarian steroidsS K Das
Department of Obstetrics Gynecology, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City 66160 7338
Endocrinology 130:3459-66. 1992..In comparison, neither an injection of E2 nor one of P4 exerted significant effects on TGF beta 3 mRNA levels.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Enhanced tumorigenesis and reduced transforming growth factor-beta type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-beta1Y Kang
Medicine Branch, National Cancer Institute, Rockville, Maryland 20850, USA
Mol Carcinog 29:112-26. 2000....
- Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneysD Bosukonda
Creative BioMolecules, Inc, Hopkinton, Massachusetts, USA
Kidney Int 58:1902-11. 2000..The molecular events involved in OP-1 action on kidney are not yet understood...
- Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding geneK Nishida
Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA
Spine (Phila Pa 1976) 24:2419-25. 1999..Gene therapy therefore may have useful applications for study of the basic science of the intervertebral disc and for clinical management of degenerative disc disease...
- Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesisM Melnick
Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
Dev Dyn 211:11-25. 1998..We present an epigenetic model of information processing related to cell proliferation. The model is a dynamical network that uses continuous logic to learn its rules from changing conditions...
- Expression of transforming growth factor-alpha and epidermal growth factor receptor mRNA in the gastric mucosa of portal hypertensive ratsJan Sing Hsieh
Department of Surgery, Kaohsiung Medical University Hospital, No 100, Shih Chuan 1st Road, Kaohsiung 807, Taiwan
Hepatogastroenterology 50:1305-10. 2003....
- Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytesP E Poleni
Laboratoire de Physiopathologie et Pharmacologie Articulaires LPPA, UMR 7561 CNRS UHP Nancy 1, avenue de la Forêt de Haye, BP 184, 54505 Vandoeuvre Les Nancy Cedex, France
Osteoarthritis Cartilage 15:493-505. 2007....
- Coordinate regulation by diethylstilbestrol of the platelet-derived growth factor-A (PDGF-A) and -B chains and the PDGF receptor alpha- and beta-subunits in the mouse uterus and vagina: potential mediators of estrogen actionK Gray
Laboratory of Developmental and Reproductive Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Endocrinology 136:2325-40. 1995..After DES treatment, the uterus exhibits a significant decrease in the level of PDGF ligand and receptor proteins immunostained within 6 h, whereas less dramatic effects ar observed in the vagina.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cellsL April Gago
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
Am J Obstet Gynecol 189:1620-5; discussion 1625-6. 2003....
- Role of interleukin-10 and transforming growth factor beta 1 in otitis media with effusionShou Qin Zhao
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing 100730, China
Chin Med J (Engl) 122:2149-54. 2009....
- The effect of transforming growth factor beta1 (TGF-beta1) on the regenerate bone in distraction osteogenesisKorhan Ozkan
Department of Orthopedics and Traumatology, Goztepe Education and Research Hospital, Istanbul, Turkey
Growth Factors 25:101-7. 2007..Most probably, type 1 receptors are up-regulated by this exogenous administration, but unfortunately, there is currently no specific stain on tha market to display type 1 receptors and to prove this explanation...
- Comparison of the antisecretory and antiulcer activity of epidermal growth factor, urogastrone and transforming growth factor alpha and its derivative in rodents in vivoS M A Bastaki
Department of Pharmacology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain
Mol Cell Biochem 236:83-94. 2002..The present study also suggests that EGF, UG and TGFalpha are equally effective against AE-induced gastric ulcer and bring about their cytoprotective action through their reduction of acid secretion and through PG and NO pathways...
- Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosisBin Bin Zhang
Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
World J Gastroenterol 9:2490-6. 2003..To determine whether these factors or enzymes could be used as the indices for the diagnosis of hepatic fibrosis, we investigated them by means of receiver operating characteristic (ROC) curve...
- Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI geneHenrik Karring
Center for Insoluble Protein Structures, Department of Molecular Biology, Science Park, University of Aarhus, Aarhus C, Denmark
Mol Vis 13:997-1004. 2007..Therefore, we investigated the specificity of the originally utilized anti-p68(beta ig-h3) antiserum and re-evaluated the amount of TGFBIp in human plasma by immunoblotting using a new specific antiserum...
- Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosisAgostino Molteni
Department of Pathology and Basic Medicinal Science, University of Missouri at Kansas City, Truman Medical Center, Kansas City, MO 64108, USA
Curr Pharm Des 13:1307-16. 2007....
- [The role of transforming growth factor-beta1/Smad3 signaling in bronchiolitis obliterans following lung transplantation]Hong Xu Liu
Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, China
Zhonghua Yi Xue Za Zhi 87:2069-73. 2007..To investigate the mechanism underlying bronchiolitis obliterans (OB) following lung transplantation and the significance of transforming growth factor (TGF)-beta1/Smad3 signal pathway in this pathological process...
- Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiationC E Rube
Department of Radiooncology, University of Munster, Munster, Germany
Int J Radiat Oncol Biol Phys 47:1033-42. 2000..The purpose of this investigation was to evaluate the acute and long-term effects of radiation on the gene expression of transforming growth factor beta (TGF-beta) in a model of lung injury using fibrosis-sensitive C57BL/6 mice...
- Regulation of transforming growth factor-beta1 expression by granulocyte macrophage-colony-stimulating factor in leiomyoma and myometrial smooth muscle cellsN Chegini
Department of Obstetrics and Gynecology, University of Florida, Gainesville 32610, USA
J Clin Endocrinol Metab 84:4138-43. 1999....
- [Effect on transforming growth factor-beta1 of glucocorticoid-induced avascular necrosis of femoral head in rats by treatment of activating blood circulation of Chinese herbal medicine]Zhen xi Qi
Department of Technological Industry, Fujian TCM College, Fuzhou 350003, Fujian, China
Zhongguo Gu Shang 22:596-8. 2009..To interpret the mechanism of the effect on Steroid-avascular necrosis of femoral head by activating blood circulation,and offer a effective method to clinical...
- Differential expression of transforming growth factor-alpha and macrophage colony-stimulating factor/colony-stimulating factor-1R (c-fins) by multinucleated giant cells involved in pathological bone resorption at the site of orthopaedic implantsN Al-Saffar
Department of Histopathology, Royal Free and University College Medical School, Hampstead, London, England
J Orthop Res 18:800-7. 2000....
- Increased release of transforming growth factor (TGF)-beta1, TGF-beta2, and chemoattractant mediators in pneumoniaF Buhling
Institute of Immunology, Otto von Guericke University Magdeburg, Germany
J Interferon Cytokine Res 19:271-8. 1999..42 nmol/L). Our results strongly suggest that different lung diseases do differ with regard to the released cytokines. TGF-beta1 probably plays a key role in regulation of pulmonary inflammation, particularly in pneumonia...
- A transforming growth factor-beta1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpuraP O Andersson
Department of Internal Medicine, Sahlgrenska University Hospital, University of Goteborg, Sweden
Ann Hematol 79:507-13. 2000..We propose that the effect of possible expression of TGF-beta1 by oral immune tolerance induction deserves to be explored in ITP patients with an active disease...
- Biodegradable chitosan scaffolds containing microspheres as carriers for controlled transforming growth factor-beta1 delivery for cartilage tissue engineeringDao Zhang Cai
Department of Orthopedics, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
Chin Med J (Engl) 120:197-203. 2007..In this study, we assessed the feasibility of using biodegradable chitosan microspheres as carriers for controlled TGF-beta1 delivery and the effect of released TGF-beta1 on the chondrogenic potential of chondrocytes...
- Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrilsM A Gibson
Department of Pathology, University of Adelaide, South Australia
Mol Cell Biol 15:6932-42. 1995..Thus, LTBP-2 appears to share functional characteristics with both LTBP-1 and fibrillins...
- Ligand Directed Transdermal siRNA Delivery to Improve Wound HealingDavid M Evans; Fiscal Year: 2012..The outcome of this project will be the initial characterization of a valuable therapeutic option for treatment of patients with various types of skin wounds. ..
- Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of SclerodRobert B Zurier; Fiscal Year: 2012..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA). ..
- REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASESMelanie H Cobb; Fiscal Year: 2012..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
- BBP (Bone Morphogenetic Protein Binding Peptide) and Bone HealingSAMUEL SCOTT MURRAY; Fiscal Year: 2013..We will also determine how the native bone protein spp24 (secreted phosphoprotein-24 kDa) inhibits BMP/TGF-b-dependent tumor cell growth. ..
- Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and PreventionTed A Bateman; Fiscal Year: 2013....
- Mechanisms of TGFB Signal TransductionAkiko Hata; Fiscal Year: 2013..Germline mutations of the type II BMP receptor (BMPRII) gene are associated with IPAH. By studying a protein called FHL2 that interacts with BMPRII and regulates BMPRII function, this application will investigate the etiology of IPAH. ..
- Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 InhibitorHiroshi Nakamura; Fiscal Year: 2013..The in vitro and in vivo results will be valuable for glaucoma therapy as well as in treatments for other ocular disorders related to scarring, such as proliferative vitreoretinopathy. ..
- Mechanisms of Airway Smooth Muscle HypertrophyMarc B Hershenson; Fiscal Year: 2013..Completion of this work will provide insight into the pathogenesis of BPD, lead to the development of more accurate biomarkers, and provide new information on the role of matricellular proteins in lung fibrosis. ..
- Engineering the Brain Immune System for Tumor TherapyMaria G Castro; Fiscal Year: 2013....
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2013..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
- Hepatocyte Nox proteins in the pathogenesis of hepatocellular carcinomaJinah Choi; Fiscal Year: 2013..Results from this study will increase our understanding of hepatocyte Nox4 and the role of inflammation in cancer, for the development of therapy. ..
- Periostin Regulation of Lung FibrosisBethany B Moore; Fiscal Year: 2013..via which periostin and TGFb regulate each other and the function of lung mesenchymal cells Aim 4) To determine whether periostin levels in plasma or bronchoalveolar lavage fluid of IPF patients correlate with disease progression ..
- TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGNamasivayam Ambalavanan; Fiscal Year: 2012....
- Caveolins in the Pathogenesis of Idiopathic Pulmonary FibrosisDan N Predescu; Fiscal Year: 2010..End of Abstract) ..
- Mouse Models of Non-Syndromic Cardiac ProgeriaAli J Marian; Fiscal Year: 2012..The models could afford the opportunity to delineate the molecular and cellular mechanisms of cardiolaminopathy and shed light into the mechanisms of cardiovascular senescence. ..
- Hepatitis C virus and liver fibrogenesisGulam Waris; Fiscal Year: 2010..The information resulting from these investigations has a potential to provide clues to how HCV-induced oxidative stress and calcium signaling may induce profibrogenic factor, TGF-21, liver fibrosis and ultimately liver cancer. ..
- Regulation of TGF-beta Signaling and Embryonic Development by GTPasesGerald H Thomsen; Fiscal Year: 2010..Our studies will provide crucial information about GTPBPs which may eventually translate into clinical treatments for diseases caused by abnormal TGF[unreadable] or GTPBP signaling. ..
- Virus interference with Toll like Receptor Response on Dendritic CellsElina I Zuniga; Fiscal Year: 2010..This proposal addresses the mechanisms by which DC-TLR responses are altered during viral infections and thus has the potential to provide novel therapeutic strategies to fight-off opportunistic pathogens associated with viral diseases. ..
- Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular HemorrhagePraveen Ballabh; Fiscal Year: 2010..To address these issues, we will use prematurely delivered rabbit pups as an experimental animal and will also use autopsy materials from premature infants with and without brain hemorrhage. ..
- GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTESKevin E Behrns; Fiscal Year: 2010..3) To determine if cirrhotic human hepatocytes are resistant to TGFbeta-induced apoptosis via mechanisms that are operative in a murine model. ..
- Innate immunity in dermal fibrosis and systemic sclerosisROBERT A LAFYATIS; Fiscal Year: 2013....
- TGF-Beta in Intimal Hyperplasia after Vascular BypassK Craig Kent; Fiscal Year: 2013..The long-term goal is to develop specific therapies that prevent or halt the progression of arterial restenosis, thus reducing morbidity and mortality for thousands of individuals each year. ..
- Bone Morphogenic Protein Signaling Pathways in Uterine BiologyMartin M Matzuk; Fiscal Year: 2013....
- Cellular Senescence and GlaucomaPedro Gonzalez; Fiscal Year: 2011....
- Mechanism of Renal Cell Injury in DiabetesGoutam Ghosh Choudhury; Fiscal Year: 2013....
- REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORSGREGORY SCOTT SCHULTZ; Fiscal Year: 2012....
- C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVALMario Chojkier; Fiscal Year: 2012..These studies are relevant to the hepatocyte proliferation and survival characteristic of many physiological and pathological conditions, including hepatocellular injury, liver regeneration and hepatocellular carcinoma. ..
- Individual Predoctoral Dental Scientist FellowshipAngela Gullard; Fiscal Year: 2013..This research will elucidate the role of tooth/bone matrix material properties in oral and skeletal health and disease. ..
- The Impact of Oxidative Stress on HIV-induced Lung DiseaseJesse Roman; Fiscal Year: 2013..If found to be causal, Eh Cys/CySS and nAChRs can be targeted for intervention in the hope of reducing the incidence and/or severity of HIV-related non-infectious lung disease. ..
- Role of Bone Morphogenetic Protein 4 in Hypoxic Pulmomary HypertensionJian Wang; Fiscal Year: 2013..Our study focuses on investigation of whether and how BMP4 regulates this process, which, if successful, will lead to improved methods of pharmacological prevention and treatment of this lethal complication of chronic lung diseases. ..
- Gene therapy in the corneaRAJIV RAVINDRA MOHAN; Fiscal Year: 2012..Targeted gene therapy delivered to the cornea with a simple topical technique offers promise to cure, treat and/or prevent vision loss by modulating excessive healing mechanisms that cause these blinding corneal disorders. ..
- Collagenase degradation in extracellular matrix in agingGary J Fisher; Fiscal Year: 2010....
- Role of trabecular meshwork contractility in modulating outflow resistanceCHEE HIAN TAN; Fiscal Year: 2013..This project studies a potential mechanism for regulating intraocular pressure that can help us better understand glaucoma and ways to treat it. ..
- Development of a Topical Choroid Plexus Factor Product to Accelerate Wound HealinCHRISTOPHER GORDON THANOS; Fiscal Year: 2011....
- Epithelial JNK-TGFb1 Signaling Axis in Airway RemodelingYvonne M W Janssen-Heininger; Fiscal Year: 2013..We will assess the impact of delivery of let-7g pre-miRNA on HDM-induced remodeling. ..
- Role of miRNAs in Vascular PhysiologyAkiko Hata; Fiscal Year: 2012..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
- Dysregulation of the Tumor Microenvironment in Hepatocellular CarcinomaLewis R Roberts; Fiscal Year: 2010..This study will investigate the function of recently discovered sulfatase enzymes that enhance growth of liver cancers, with the goal of developing effective treatments for this devastating disease. ..
- Interactions of Lipoproteins with the Vascular WallJOHN CALVERT RUTLEDGE; Fiscal Year: 2010....
- Effects of Alcohol on Stem Cells in the Adult BrainMichael W Miller; Fiscal Year: 2012..Such data are of key importance for our understanding of other neurodegenerative diseases (e.g., Alzheimer's and Parkinson's Diseases) and for the developmental of therapeutic strategies to address these diseases. ..
- Smooth Muscle Differentiation and MaturationShiyou Chen; Fiscal Year: 2013..Our proposal examining the molecular mechanisms that regulate smooth muscle differentiation should help to identify therapeutic targets for the treatment of these diseases. ..
- Using Genetics For Early Phenotyping &Prevention of Hypertrophic CardiomyopathyChristine E Seidman; Fiscal Year: 2013..Early treatment can be targeted to at-risk, genetically susceptible individuals to offset the consequences of pathogenic mutations and prevent disease progression. ..
- MOLECULAR MANIPULATION TO ENHANCE ANTI-MYELOMA RESPONSENikhil C Munshi; Fiscal Year: 2013..The proposed studies will identify the mechanism of immune suppression in myeloma, develop methods to improve immune function and develop peptide-based vaccination strategies to preclinical rational for their clinical application. ..
- EFFECT OF ETHANOL ON CELL PROLIFERATIONMichael W Miller; Fiscal Year: 2010....
- Systems analysis of TGFbeta signaling and SnoN function in liverKunxin Luo; Fiscal Year: 2013..The long-term goal of this project is to understand how proper levels of TGF2 signaling activity are maintained and regulated in normal tissues and primary cells using a system biology approach. ..
- Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic AneurysmsJeffrey A Jones; Fiscal Year: 2013....
- MECHANISMS OF PULMONARY FIBROSISSem H Phan; Fiscal Year: 2010..several key cytokines with fibrogenic activities, including monocyte chemotactic protein-1 (MCP-1), transforming growth factors a (TGFa) and (}(TGFp)...
- Mechanisms of Antifibrotic Actions of Relaxin in the LiverRobert G Bennett; Fiscal Year: 2013..The research proposed in this application may lead to targeted therapeutic strategies for the treatment of liver disease, a major health concern in the United States. ..
- Investigations of the optimum serum bicarbonate level in renal diseaseKALANI LUKELA RAPHAEL; Fiscal Year: 2013..With continued supervision by my mentors and by being at an institution with the resources and dedication to facilitate the development of young faculty members, I am confident that I will be successful. ..
- Discovering Microenvironments Promoting Pathological EMT using Array TechnologyNaira Serobyan; Fiscal Year: 2012....
- Human Milk Factor Protection in Neonatal Necrotizing EnterocolitisSheng Ru Shiou; Fiscal Year: 2012..This proposal will investigate how Epo and TGF-b protect immature intestine, in order to develop a treatment to prevent or ameliorate NEC in vulnerable infants. ..
- Angiotensin-II, Hypothalamic Inflammation and Neurogenic HypertensionANNETTE DIANE DE KLOET; Fiscal Year: 2012..This is of particular relevance to public health because uncovering the mechanisms of Ang-II regulation of inflammation and cardiovascular function may lead to new strategies for the treatment and prevention of hypertension. ..
- Control of Colonic Inflammation and Tumor Growth by TGFBeta and Dietary Vitamin DLillian Maggio-Price; Fiscal Year: 2012..The detailed understanding of dietary effects and molecular mechanisms will permit more targeted and effective therapies for treatment of these diseases. ..
- TGF beta-induced apoptosis in B-lymphocytesPhilip H Howe; Fiscal Year: 2013..Our research may identify factors and important regulatory pathways that could be used therapeutically to modulate Bim expression in vivo. ..
- Retinoids and Hyperoxic Lung InjuryMasheika L James; Fiscal Year: 2012..abstract_text> ..
- Individual Predoctoral Dental Scientist FellowshipMELISSA ANNE TALBERT; Fiscal Year: 2011..The goal of this study is to improve implant biocompatibility with host tissue by elucidating the role of mesenchymal stem cells in TGF-?[unreadable] dependent fibrous tissue formation. ..
- Myostatin Regulation of Skeletal Muscle Energy MetabolismSUZANNE PORSZASZ-REISZ; Fiscal Year: 2013..This study will focus on Mst function in adulthood and will enhance our understanding of the regulatory role of Mst and may additionally provide insight into the treatment of muscle loss and metabolic syndrome. ..
- microRNA regulatory function in Leiomyoma growthXiaoping Luo; Fiscal Year: 2010..This proposal will investigate how fibroids grow and ways to prevent their symptoms and growth. ..
- Determinants and Cardiovascular Consequences of Diabetes in Older AdultsSusan J Zieman; Fiscal Year: 2012....
- EFFECT OF ETHANOL ON CELL PROLIFERATIONFrank A Middleton; Fiscal Year: 2013..In concert, the novel Aims will use three complementary models to gain critical insight into mechanisms defining cell proliferation and fate and the effects of ethanol on these critical factors. ..
- Mechanisms of RelA Activation in CancerPaul J Chiao; Fiscal Year: 2013..Most importantly, this study may discover novel molecular targets for improving the treatment for pancreatic cancer. ..
- Regulatory Mechanisms of Implant-Induced OsteolysisYousef Abu-Amer; Fiscal Year: 2013..Our proposal addresses novel questions and holds promise to identify novel selective anti-osteolytic therapies. ..
- Ac-SDKP for Treatment of Acute StrokeZheng Gang Zhang; Fiscal Year: 2013..These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke. ..
- Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic RetinopathySTEPHEN BARTELMEZ; Fiscal Year: 2009..If this treatment proves to be safe and effective, it will be the first "cure" for diabetic retinopathy. ..
- HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITISSTEVEN KINCAID; Fiscal Year: 1991..The results will establish the capacity of HA/TGF-B to sustain proteoglycan syntheses to facilitate repair of osteoarthritic articular cartilage...
- FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung CanceFeng Ming Kong; Fiscal Year: 2009..If successful, future radiation therapy could be personalized based on their response to radiation and treatment gain could be maximized. ..
- Trafficking of BMP signals in neuronsGuillermo Marques; Fiscal Year: 2007..unreadable] [unreadable]..
- Impact of Puberty on the Kidney in DiabetesPASCALE LANE; Fiscal Year: 2005..Health implications: New treatments to prevent diabetic kidney disease, the most important cause of kidney failure in the US, may emerge from a better understanding of a naturally protected state such as the prepubertal animal. ..
- CELL-CELL INTERACTIONS IN TESTIS DEVELOPMENTMichael Skinner; Fiscal Year: 2007..e. cord formation) that transforming growth factors (i.e...
- MESENCHYMAL/EPITHELIAL CELL INTERACTIONS IN THE OVARYMichael Skinner; Fiscal Year: 2000..Observations are anticipated to provide insight into the molecular and cellular control of ovarian physiology. ..
- Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem CellsSTEPHEN BARTELMEZ; Fiscal Year: 2009..Our focus is to demonstrate proof of principle that adult HSC can be effectively used to repair infarcted coronary vessels and eventually greatly improve the quality and duration of these patient's lives. ..