insulin like growth factor i


Summary: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.

Top Publications

  1. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
  2. ncbi The insulin-like growth factor system and cancer
    Derek LeRoith
    Diabetes Branch, Room 8D12, Building 10, National Institutes of Health MSC 1758, Bethesda, MD 20892 1758, USA
    Cancer Lett 195:127-37. 2003
  3. ncbi Extended longevity in mice lacking the insulin receptor in adipose tissue
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA
    Science 299:572-4. 2003
  4. ncbi Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    A Musaro
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
    Nat Genet 27:195-200. 2001
  5. ncbi Insulin and insulin-like growth factor signalling in neoplasia
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 8:915-28. 2008
  6. ncbi Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    Y Lu
    Department of Oncology, Jewish General Hospital, and McGill University, Montreal, PQ, Canada
    J Natl Cancer Inst 93:1852-7. 2001
  7. ncbi Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
  8. ncbi Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities
    R C Baxter
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    Am J Physiol Endocrinol Metab 278:E967-76. 2000
  9. ncbi Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling
    Meng Ru Shen
    Department of Pharmacology, National Cheng Kung University, Tainan 704, Taiwan
    Carcinogenesis 27:962-71. 2006
  10. ncbi Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    K T Coschigano
    Edison Biotechnology Institute, Ohio University, Athens 45701, USA
    Endocrinology 141:2608-13. 2000

Detail Information

Publications359 found, 100 shown here

  1. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
  2. ncbi The insulin-like growth factor system and cancer
    Derek LeRoith
    Diabetes Branch, Room 8D12, Building 10, National Institutes of Health MSC 1758, Bethesda, MD 20892 1758, USA
    Cancer Lett 195:127-37. 2003
    ..In this review, many aspects of the IGF system and its relationship to cancer will be discussed...
  3. ncbi Extended longevity in mice lacking the insulin receptor in adipose tissue
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA
    Science 299:572-4. 2003
    ..Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling...
  4. ncbi Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    A Musaro
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
    Nat Genet 27:195-200. 2001
    ..The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty...
  5. ncbi Insulin and insulin-like growth factor signalling in neoplasia
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 8:915-28. 2008
    ..Recent results are encouraging and have justified the expansion of many translational research programmes...
  6. ncbi Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    Y Lu
    Department of Oncology, Jewish General Hospital, and McGill University, Montreal, PQ, Canada
    J Natl Cancer Inst 93:1852-7. 2001
    ..Thus, strategies that target IGF-IR signaling may prevent or delay development of resistance to trastuzumab...
  7. ncbi Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
    ..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
  8. ncbi Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities
    R C Baxter
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    Am J Physiol Endocrinol Metab 278:E967-76. 2000
    ..The regulation of cell sensitivity to inhibitory IGFBP signaling may play a role in the growth control of malignant cells...
  9. ncbi Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling
    Meng Ru Shen
    Department of Pharmacology, National Cheng Kung University, Tainan 704, Taiwan
    Carcinogenesis 27:962-71. 2006
    ..Thus, these data suggest that the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer...
  10. ncbi Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    K T Coschigano
    Edison Biotechnology Institute, Ohio University, Athens 45701, USA
    Endocrinology 141:2608-13. 2000
    ..Finally, the -/- mice lived significantly longer than +/+ and +/- mice. The latter result contradicts the anti-aging GH data and suggests the need for further analysis of GH and aging...
  11. ncbi Systemic complications of acromegaly: epidemiology, pathogenesis, and management
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    Endocr Rev 25:102-52. 2004
    ..Finally, the most important cause of morbidity and functional disability of the disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years...
  12. ncbi Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
    S E Dunn
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 57:4667-72. 1997
    ..This is the first mechanistic study demonstrating that IGF-I supplementation abrogates the protective effect of DR on neoplastic progression...
  13. ncbi The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways
    S A Coolican
    Biology Department, Syracuse University, Syracuse, New York 13244, USA
    J Biol Chem 272:6653-62. 1997
    ..Thus, it appears that signaling from the IGF-I receptor utilizes two distinct pathways leading either to proliferation or differentiation...
  14. ncbi Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    C Desbois-Mouthon
    INSERM U.402, , Paris, France
    Oncogene 20:252-9. 2001
    ..These findings demonstrate for the first time the ability of insulin and IGF-1 to activate the beta-catenin pathway in hepatoma cells and thereby provide new insights into the role of these factors in hepatocarcinogenesis...
  15. ncbi Role of insulin-like growth factors in embryonic and postnatal growth
    J Baker
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Cell 75:73-82. 1993
  16. ncbi Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
  17. ncbi The IGF-1 receptor in cancer biology
    Renato Baserga
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 624 BLSB, Philadelphia, PA 19107, USA
    Int J Cancer 107:873-7. 2003
    ..Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy...
  18. ncbi Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 277:38205-11. 2002
    ..Involvement of the MAP kinase pathway represents a novel mechanism for the induction of HIF-1 alpha protein expression in human cancer cells...
  19. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  20. ncbi Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    Brian K Kaspar
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:839-42. 2003
    ..We report that insulin-like growth factor 1 prolongs life and delays disease progression, even when delivered at the time of overt disease symptoms...
  21. ncbi Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    Constantine S Mitsiades
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Cell 5:221-30. 2004
  22. ncbi Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Lancet 363:1346-53. 2004
    ..Circulating concentrations of IGF-I might be associated with an increased risk of cancer, whereas IGFBP-3 concentrations could be associated with a decreased cancer risk...
  23. ncbi Energy balance and cancer: the role of insulin and insulin-like growth factor-I
    R Kaaks
    International Agency for Research on Cancer, Lyon, France
    Proc Nutr Soc 60:91-106. 2001
    ..For cancers of the endometrium, breast and prostate, these findings are discussed in the context of relationships between insulin and IGF-I and levels of bioavailable sex steroids...
  24. ncbi Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women
    R Kaaks
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 92:1592-600. 2000
    ..To test this hypothesis, we conducted a case-control study nested within a cohort of 14 275 women in New York...
  25. ncbi Effects of an Igf1 gene null mutation on mouse reproduction
    J Baker
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Mol Endocrinol 10:903-18. 1996
    ..The phenotypic manifestations of the mutation were correlated with the localization of transcripts for insulin-like growth factor I and its cognate receptor in wild type reproductive tissues by in situ hybridization...
  26. ncbi Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    J P Liu
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Cell 75:59-72. 1993
    ..The roles of the IGFs in mouse embryonic development, as revealed from the phenotypic differences between these mutants, are discussed...
  27. pmc Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1
    Antonio Musaro
    Department of Histology and Medical Embryology and Centro Eccellenza Biologia e Medicina Molecolare, University of Rome La Sapienza, 00161 Rome, Italy
    Proc Natl Acad Sci U S A 101:1206-10. 2004
    ..These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms...
  28. ncbi Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study
    A Wolk
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    J Natl Cancer Inst 90:911-5. 1998
    ..Our goal was to determine whether an association exists between serum levels of IGF-1 and one of its binding proteins, insulin-like growth factor-binding protein 3 (IGFBP-3), and prostate cancer risk...
  29. ncbi IGF-I is required for normal embryonic growth in mice
    L Powell-Braxton
    Department of Endocrine Research, Genentech, Inc, South San Francisco, California 94080 4990
    Genes Dev 7:2609-17. 1993
    ..Histopathology is characterized by underdevelopment of muscle tissue. Lungs of late embryonic and neonates also appeared less organized with ill-defined alveolae. IGF-I appears to be essential for correct embryonic development in mice...
  30. ncbi Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    H Tamemoto
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 372:182-6. 1994
    ..They also had resistance to the glucose-lowering effects of insulin, IGF-1 and IGF-2. These data suggest the existence of both IRS-1-dependent and IRS-1-independent pathways for signal transduction of insulin and IGFs...
  31. ncbi A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
    Laura J Niedernhofer
    Center for Biomedical Genetics Medical Genetic Center Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Nature 444:1038-43. 2006
  32. pmc The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling
    Wendy M Shaw
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 17:1635-45. 2007
    ..elegans TGF-beta Dauer pathway is responsible solely for the regulation of dauer formation, with no role in longevity regulation, whereas the insulin/IGF-1 signaling (IIS) pathway regulates both dauer formation and longevity...
  33. ncbi Mechanism of insulin-like growth factor I-mediated proliferation of adult neural progenitor cells: role of Akt
    Haviryaji S G Kalluri
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
    Eur J Neurosci 25:1041-8. 2007
    ..The decrease in the cyclin D1 content in conjunction with the inhibition of nestin expression by ERK inhibitor confirms the role of ERK in the proliferation of cells...
  34. pmc Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    Marta Guix
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6307, USA
    J Clin Invest 118:2609-19. 2008
    ..Moreover, combined therapeutic inhibition of EGFR and IGFIR may abrogate this acquired mechanism of drug resistance and is thus worthy of prospective clinical investigation...
  35. ncbi IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness
    Yueh Mei Hsu
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    J Cell Physiol 210:626-36. 2007
    ..Thus, we conclude that KCC activation by IGF-1 plays an important role in IGF-1 receptor signaling to promote growth and spread of breast cancer cells...
  36. ncbi PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone
    Lisandro Laurino
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba y CIQUIBIC, CONICET, Cordoba 5000, Argentina
    J Cell Sci 118:3653-62. 2005
    ..Taken together, our results suggest a critical role for IGF-1 and the IRS/PI3K/Akt pathway in the process of membrane assembly at the axonal growth cone...
  37. pmc Effects of rehabilitative exercise on peripheral muscle TNFalpha, IL-6, IGF-I and MyoD expression in patients with COPD
    Ioannis Vogiatzis
    National and Kapodistrian University of Athens Thorax Foundation, 3 Ploutarhou Str 106 75, Athens, Greece
    Thorax 62:950-6. 2007
    ..This study investigated whether rehabilitative exercise training decreases the levels of systemic or local muscle inflammation or reverses the abnormalities associated with muscle deconditioning...
  38. ncbi IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)
    S Rinaldi
    International Agency for Research on Cancer IARC WHO, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Endocr Relat Cancer 13:593-605. 2006
  39. ncbi A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly
    Shlomo Melmed
    Department of Medicine, Cedars Sinai Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4405-10. 2005
  40. ncbi The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical 'cure'
    Panagiotis Nomikos
    Department of Neurosurgery, University of Erlangen Nurnberg, Erlangen, Germany
    Eur J Endocrinol 152:379-87. 2005
    ..The aim of this study was to illustrate the present role of transsphenoidal surgery as primary therapy in GH-secreting adenomas, and to compare the results concerning control of disease with previous series using older criteria of cure...
  41. ncbi An alternatively spliced human insulin-like growth factor-I transcript with hepatic tissue expression that diverts away from the mitogenic IBE1 peptide
    S L Chew
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    Endocrinology 136:1939-44. 1995
  42. ncbi A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:345-9. 2000
    ..These analyses indicate that high levels of circulating IGF-1 and particularly low levels of IGFBP-3 are associated independently with an elevated risk of large or tubulovillous/villous colorectal adenoma and cancer...
  43. ncbi Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    Karen T Coschigano
    Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 144:3799-810. 2003
    ..Finally, life span was significantly extended for the GHR -/- mice but remained unchanged for GHA dwarfs. These results suggest that the degree of blockade of GH signaling can lead to dramatically different phenotypes...
  44. ncbi Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
    L E Smith
    Department of Ophthalmology, Harvard Medical School and Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 5:1390-5. 1999
    ..They also explain why diabetic retinopathy initially increases with the onset of insulin treatment. IGF-1 levels, low in untreated diabetes, rise with insulin therapy, permitting VEGF-induced retinopathy...
  45. ncbi Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I
    M Kanzaki
    Department of Cell Biology, Gunma University, Maebashi, Japan
    Nat Cell Biol 1:165-70. 1999
    ..Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane. Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel...
  46. ncbi Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis
    Roger Abs
    Department of Endocrinology, University Hospital, Antwerp, Belgium
    Eur J Endocrinol 155:79-90. 2006
    ..The aim of the present study was to clarify the relationship between GH deficiency (GHD) and some cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large number of patients over a prolonged period of time...
  47. ncbi Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
    Derek LeRoith
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nat Clin Pract Endocrinol Metab 3:302-10. 2007
    ..For example, excess growth hormone causes insulin resistance and hyperglycemia, whereas IGF1 has insulin-like effects that reduce blood glucose levels and has been used experimentally to treat both type 1 and type 2 diabetes...
  48. ncbi Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy
    Am J Physiol Endocrinol Metab 284:E481-7. 2003
    ..This mechanism may explain why IL-6 is a strong risk factor for disability...
  49. ncbi Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    Arnold J Levine
    The Institute for Advanced Study, Princeton, New Jersey 08540, USA
    Genes Dev 20:267-75. 2006
    ..In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity...
  50. ncbi Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
    Andrew P Gilmore
    School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 277:27643-50. 2002
    ..Our results indicate that by targeting a growth factor-mediated survival signaling pathway, BAD phosphorylation can be manipulated therapeutically to induce apoptosis...
  51. ncbi Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2
    Y Arsenijevic
    Division of Surgical Research and Gene Therapy Center, Pavillon 4 Centre Hospitalier Universitaire Vaudois, 1004 Lausanne, Switzerland
    J Neurosci 21:7194-202. 2001
    ..These findings suggest that IGF-I is a key factor in the regulation of NSC activation and that EGF and FGF-2 control striatal NSC proliferation, in part, through distinct intracellular mechanisms...
  52. ncbi The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index
    Ginevra Corneli
    Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, University of Turin, Italy
    Eur J Endocrinol 153:257-64. 2005
    ..Aim of this study was to evaluate the diagnostic cut-off limits of peak GH response to the GHRH-ARG test in overweight and obese as well as in lean population...
  53. ncbi Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation
    David Kuninger
    Molecular Medicine Division, HRC 3, Department of Medicine, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    Genomics 84:876-89. 2004
    ..Our results demonstrate the power of transcriptional profiling for gene discovery and provide opportunities for investigating new proteins potentially involved in different aspects of growth factor action in muscle...
  54. ncbi Reduced insulin/IGF-1 signalling and human longevity
    Diana van Heemst
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 4:79-85. 2005
    ..This effect was stronger for the GH1 SNP than for variation in the conserved IIS genes that were found to affect longevity in model organisms...
  55. ncbi Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency
    Beverly M K Biller
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:2067-79. 2002
    ..The ARG plus GHRH test represents an excellent alternative to the ITT for the diagnosis of GH deficiency in adults...
  56. ncbi Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival
    Wen Hua Zheng
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Neurochem 89:844-52. 2004
    ..Taken together, these data reveal that the survival properties of both IGF-1 and BDNF against serum deprivation are mediated by the activation of the PI3K/Akt, but not the MAPK, pathway in hippocampal neurons...
  57. ncbi Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene
    A Shimatsu
    J Biol Chem 262:7894-900. 1987
    ..A comparably high degree of amino acid sequence identity is also found for both the amino- and carboxyl-terminal extension peptides, suggesting that, like mature IGF-I, the extension molecules may have physiological function...
  58. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling...
  59. ncbi Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I)
    H Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University, Homburg, Germany
    Gene Ther 12:1171-9. 2005
    ..These results suggest that therapeutic growth factor gene delivery using encapsulated and transplanted genetically modified chondrocytes may be applicable to sites of focal articular cartilage damage...
  60. ncbi IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice
    Sergiy Sukhanov
    Cardiology Section, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, SL 48, New Orleans, LA 70112, USA
    Arterioscler Thromb Vasc Biol 27:2684-90. 2007
    ..Here we report for the first time that IGF-1 infusion decreased atherosclerotic plaque progression in ApoE-deficient mice on a Western diet...
  61. ncbi Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
    ..This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment...
  62. pmc Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage
    Maria Hill
    Basic Medical Sciences and Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Physiol 549:409-18. 2003
    ..Later splicing of the IGF-I gene away from MGF but towards IGF-IEa seems physiologically appropriate as IGF-IEa is the main source of mature IGF-I for upregulation of protein synthesis required to complete the repair...
  63. ncbi Regulation of apoptosis by insulin-like growth factor (IGF)-I
    Ron Kooijman
    Department of Pharmacology, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cytokine Growth Factor Rev 17:305-23. 2006
    ..This phenomenon may explain the efficacy of IGF-I as an inhibitor of apoptosis in many different cell types and in the presence of different apoptogenic stimuli...
  64. ncbi Genetic control of longevity in C. elegans
    Bart P Braeckman
    Biology Department, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Exp Gerontol 42:90-8. 2007
    ..However, their high antioxidant capacity may result in lower oxidative damage. Enhanced molecular turnover rates may also play a role in their longevity phenotype...
  65. ncbi Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro
    Toan Thang Phan
    National Burns Centre, Singapore General Hospital, Singapore 169608
    Am J Physiol Cell Physiol 284:C860-9. 2003
  66. ncbi Pasireotide (SOM230): development, mechanism of action and potential applications
    Herbert A Schmid
    Novartis Institutes for BioMedical Research, Oncology Research, Novartis Pharma AG, Basel, Switzerland
    Mol Cell Endocrinol 286:69-74. 2008
  67. ncbi Extracellular control of cell size
    I J Conlon
    MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK
    Nat Cell Biol 3:918-21. 2001
  68. ncbi Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)
    Martin W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    Clin Chem Lab Med 42:654-64. 2004
    ..5th centile. In conclusion, the automated IMMULITE IGF-I and IGFBP-3 assays are reliable tools in the diagnosis of pathologies of the GH/IGF axis and in the follow-up of their therapies...
  69. pmc Enhancing repair of the mammalian heart
    Maria Paola Santini
    European Molecular Biology Laboratory, Mouse Biology Unit Monterotondo, Rome, Italy
    Circ Res 100:1732-40. 2007
    ..The robust response achieved with the mIGF-1 isoform provides a mechanistic basis for clinically feasible therapeutic strategies for improving the outcome of heart disease...
  70. ncbi A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly
    I M Holdaway
    Department of Endocrinology, Greenlane Clinical Centre and Auckland City Hospital, PO Box 92189, Auckland 1142, New Zealand
    Eur J Endocrinol 159:89-95. 2008
    ..A meta-analysis of mortality studies in acromegaly has thus been performed to assess the effect of lowering serum GH and IGF-I on survival...
  71. ncbi TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
    Keyong Du
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 1002, USA
    Science 300:1574-7. 2003
    ..Our results suggest that, by interfering with Akt activation, TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes...
  72. ncbi The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes
    C M Boney
    Department of Pediatrics Rhode Island Hospital, Providence 02903, USA
    Mol Endocrinol 14:805-13. 2000
    ..Our results suggest that loss of the ability of IGF-I to activate Shc signaling to MAPK may be an early component of adipogenesis in 3T3-L1 cells...
  73. ncbi Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    Haim Y Cohen
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 305:390-2. 2004
    ..Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells...
  74. pmc Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden
    R Palmqvist
    Department of Medical Biosciences, Pathology, Umea University, SE 901 87 Umea, Sweden
    Gut 50:642-6. 2002
    ..Insulin-like growth factor 1 (IGF-1) has antiapoptotic and mitogenic effects on various cell types, and raised IGF-1 levels are increasingly being implicated as potential risk factors for cancer...
  75. pmc Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice
    J DiGiovanni
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park, Research Division, P O Box 389, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 97:3455-60. 2000
    ..These mice offer an animal model for prostate cancer that will allow study of the stepwise development of this disease and the mechanism(s) whereby IGF-1 mediates this process...
  76. ncbi Preoperative octreotide treatment in newly diagnosed acromegalic patients with macroadenomas increases cure short-term postoperative rates: a prospective, randomized trial
    Sven M Carlsen
    Department of Endocrinology, St Olavs Hospital, University Hospital of Trondheim, 7006 Trondheim, Norway
    J Clin Endocrinol Metab 93:2984-90. 2008
    ..Surgery is the primary treatment of acromegaly. However, it often fails to cure the patient. New strategies that improve surgical outcome are needed...
  77. ncbi Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK)
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 76:368-78. 2007
    ..Thus, in bovine granulosa cells, metformin decreases steroidogenesis and MAPK3/MAPK1 phosphorylation through AMPK activation...
  78. ncbi Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    Hua Zhang
    University of Minnesota Cancer Center, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Res 67:391-7. 2007
    ..Because IR also activates signaling pathways similar to IGF1R in breast cancer cells, agents targeting both receptors may be necessary to disrupt the malignant phenotype regulated by this growth factor system...
  79. ncbi IGF-binding protein-2 protects against the development of obesity and insulin resistance
    Stephen B Wheatcroft
    Academic Unit of Cardiovascular Medicine, The LIGHT Laboratories, Clarendon Way, University of Leeds, Leeds LS2 9JT, U K
    Diabetes 56:285-94. 2007
    ..These findings suggest an important, novel role for IGFBP-2 in obesity prevention...
  80. ncbi Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells
    Niels Eckstein
    Center of Advanced European Studies and Research caesar, Bonn, Germany
    Cancer Res 69:2996-3003. 2009
    ..We conclude that targeting the IGF-IR and the PI3K pathways is a promising new strategy to treat cisplatin-resistant ovarian carcinomas...
  81. ncbi Growth hormone and insulin-like growth factors in fish: where we are and where to go
    Manfred Reinecke
    Division of Neuroendocrinology, Institute of Anatomy, University of Zurich, CH 8057 Zurich, Switzerland
    Gen Comp Endocrinol 142:20-4. 2005
  82. ncbi Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:852-61. 2002
    ..We conclude that higher energy, protein, and milk intakes were associated with higher levels of IGF-I. These associations raise the possibility that diet could affect cancer risk through influencing IGF-I level...
  83. ncbi Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial
    Yvonne van Pareren
    Department of Pediatrics, Division of Endocrinology, Sophia Children s Hospital Erasmus Medical Center, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3584-90. 2003
    ..In conclusion, long-term continuous GH treatment in short children born SGA without signs of persistent catch-up growth leads to a normalization of AH, even with a GH dose of 3 IU/m(2).d ( approximately 0.033 mg/kg.d)...
  84. ncbi Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cells
    Margit Pacher
    Department of Obstetrics and Gynecology, Medical University of Vienna, A 1090 Vienna, Austria
    Carcinogenesis 28:49-59. 2007
    ..We conclude that the induction of cell proliferation and tumor formation by long-term IGF stimulation may primarily be due to anabolic effects, in particular increased amino acid production and uptake...
  85. pmc daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
    Weiqing Li
    Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 17:844-58. 2003
    ..This DAF-28 mutant is likely to be poisonous to wild-type DAF-28 and other insulins...
  86. ncbi A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    Christy S Carter
    Dept Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Trends Genet 18:295-301. 2002
    ..Here, we critique the current mammalian models of GH/IGF-1 deficiency and discuss the actions of GH/IGF-1 on biological aging and lifespan...
  87. ncbi Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling
    Miranda D Grounds
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
    Biogerontology 3:19-24. 2002
    ..The possible clinical prevention of age-related muscle wasting (and associated motorneurone loss) by the locally acting muscle isoform of IGF-I is discussed...
  88. pmc IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
    Michal Rajski
    Department of Biomedicine, University of Basel, Basel, Switzerland
    BMC Med 8:1. 2010
    ..Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately...
  89. ncbi Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest
    Nicole A Bourbon
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:3286-92. 2002
    ..The therapeutic potential for ceramide to limit dysregulated VSMC growth has direct applicability to vascular diseases such as restenosis and atherosclerosis...
  90. ncbi Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density
    C J Rosen
    Jackson Laboratory, Bar Harbor, Maine 04605, USA
    J Clin Endocrinol Metab 83:2286-90. 1998
    ..Further family and pedigree studies are needed to characterize the relationship of bone mass acquisition to the IGF-I genotype...
  91. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
  92. pmc Functionally significant insulin-like growth factor I receptor mutations in centenarians
    Yousin Suh
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:3438-42. 2008
    ..Thus, genetic alterations in the human IGF1R that result in altered IGF signaling pathway confer an increase in susceptibility to human longevity, suggesting a role of this pathway in modulation of human lifespan...
  93. ncbi Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men
    Edward Giovannucci
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:84-9. 2003
    ..The age-related decline in plasma IGF-I may be exacerbated by low intakes of protein and minerals. The potential role of these dietary factors on cancer risk through altering IGF-I levels requires study...
  94. ncbi The skeletal structure of insulin-like growth factor I-deficient mice
    D Bikle
    Department of Medicine, University of California and Veterans Affairs Medical Center, San Francisco 94121, USA
    J Bone Miner Res 16:2320-9. 2001
    ..These changes were either less or not found in L1. Thus, lack of IGF-I leads to the development of a bone structure, which, although smaller, appears more compact...
  95. ncbi Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure
    P Christian Schulze
    Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 289, Cambridge, MA 02139, USA
    Basic Res Cardiol 98:267-74. 2003
  96. ncbi Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation
    Shi Yu Yang
    Molecular Tissue Repair Unit, Department of Surgery, Royal Free and University College Medical School, University College London, Rowland Hill Street, UK
    FEBS Lett 522:156-60. 2002
    ..The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected...
  97. ncbi Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides
    P Rotwein
    J Biol Chem 261:4828-32. 1986
    ..Restriction endonuclease polymorphisms in the IGF-I gene, which map near exon 5 as determined by Southern blot analysis, will be useful in defining the genetics of familial growth failure...
  98. ncbi Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons
    G Camarero
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Arturo Duperier 4, E 28029, Madrid, Spain
    Dev Biol 262:242-53. 2003
    ..IGF-1 is one of the signals underlying autonomous development of the otic vesicle...
  99. pmc Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia
    C S Mantzoros
    Department of Epidemiology and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Br J Cancer 76:1115-8. 1997
    ..This finding suggests that, in addition to testosterone, IGF-1 may increase the risk of prostate cancer in humans...
  100. ncbi IGF-I and microglia/macrophage proliferation in the ischemic mouse brain
    Steven L O'Donnell
    Department of Neuroscience and Anatomy, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 39:85-97. 2002
    ..Taken together with previous data demonstrating that IGF-I promotes proliferation of peripheral macrophages, these data support the hypothesis that IGF-I is an autocrine/paracrine mitogen for microglia/macrophages after H/I...
  101. ncbi Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults
    Matthew C Kostek
    Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
    J Appl Physiol (1985) 98:2147-54. 2005
    ..Thus these data suggest that the IGF1 promoter polymorphism may influence the strength response to ST. Larger sample sizes should be used in future studies to verify these results...

Research Grants74

  1. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
  2. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
  3. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Cachexia is also a complication of many other conditions including lung and heart disease and aging, the knowledge generated through this proposal also will help us in establishing new therapies for these conditions. ..
  4. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Moreover, elucidation of the signaling mechanisms that regulate autophagy in cardiomyocytes may lead to novel therapies for preventing or modulating heart injury as occurs in diabetes, cardiac ischemia or cardiac hypertrophy. ..
  5. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
  6. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
  7. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..Our mouse- implantable remote-control micropump technology overcomes this limitation;enabling more rapid, efficient, and economical discovery and delivery of regenerative therapies. ..
  8. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
    ..5. To prepare annual progress reports and coordinate preparation of a competing renewal application. ..
  9. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..We will subsequently test the optimal combination of these factors using gene delivery in a rodent model of this devastating disease in order to define an optimal therapy for this debilitating disorder. ..
  10. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2013
    ..Effects of DR that extend life spans in both normal control and ob/ob mice in this study are likely targets for interventions to retard aging and extend healthy lifespan in human beings. ..
  11. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
  12. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..Information gained can be used in future experiments to determine if GH acts directly or indirectly on specific tissues/cells to mediate these effects. ..
  13. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable non-toxic chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality. ..
  14. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
  15. Tea Polyphenols in Chemoprevention of Prostate Cancer
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  16. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
    ..The work in this proposal will determine if this approach is feasible using animal models of this disease state. ..
  17. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..Establishing that maternal / perinatal diet influences peak bone mass acquisition may point to diet as a modifiable risk factor for adult bone disease. ..
  18. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
  19. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2013
    ..The data obtained has the potential to facilitate the translation of pre-clinical and clinical research to public health guidelines for PA directed to cancer prevention and control. ..
  20. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..In addition, when the boys reach adulthood, environmental risk factors for altered semen quality will also be explored. ..
  21. The Organ Specific Role of Superoxide Dismutase in Sepsis
    Alix Ashare; Fiscal Year: 2010
    ..These studies have the potential to greatly impact the management of a complex disease which has a high mortality and, thus far, few therapeutic options which improve outcome. ..
  22. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..Therefore, the failure to accrue peak bone mass during the adolescent years represents a missed opportunity to optimize bone mass during one's life. ..
  23. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..According to the NIH report "the effect of food constituents on molecular events in the prostate is unknown". Discovery of Se- and isoflavone-regulated genes will "identify biomarkers of the consumption of key dietary components". ..
  24. Development of New Therapeutics for Pancreatic Cancer Management
    RICHARD JOSEPH PIETRAS; Fiscal Year: 2013
    ..Discovery and validation of potent antitumor action and tolerability of metformin analogs in vivo may lead to timely clinical trials and possibly a significant breakthrough in pancreatic cancer therapy. ..
  25. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..We hope to enhance innate immunity and/or reduce average lifespan of a model mosquito below this development period so that transmission of malaria parasites is reduced or eliminated. ..
  26. Adiposity and Outcomes of Clinically Localized Prostate Cancer
    Vincent L Freeman; Fiscal Year: 2013
    ..It will also shed light on ways to prevent prostate cancer recurrence that may involve new or existing medicines or lifestyle changes. ..
  27. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013
  28. Neonatal Programming of Growth and Maturation in Rhesus Monkeys
    Andrew Muir; Fiscal Year: 2013
    ..A nonhuman primate model of gestational overnutrition is a vital resource to explore the effects of weight on the health of mothers, children, and perhaps even subsequent generations. ..
  29. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2010
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..
  30. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  31. Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
    Ralph Rabkin; Fiscal Year: 2009
    ..If effective in these patients, then this holds the potential of improving management of patients, not only with CKD, but also those with other muscle wasting illnesses. ..
  32. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..The study will be conducted in a large, prospective cohort study of endometrial cancer (GOG-0210). ..
    C Ronald Kahn; Fiscal Year: 2013
  34. Regulation of IGF-1 and Insulin Signaling by O-GlcNAc Glycosylation
    LAUREN ELIZABETH BALL; Fiscal Year: 2013
    Maria G Buse; Fiscal Year: 2012
    ..Improved understanding of how different nutrients, when provided chronically in excess, alter the cell's response to insulin, will lead to the development of novel therapeutic targets to prevent or mitigate type 2 diabetes. ..
  36. Role of MAT and SAMe in Colon Cancer Pathogenesis and Treatment
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..abstract_text> ..
  37. IGF-1, Gender, Heart Failure and Longevity: A Paradigm Shift
    Piero Anversa; Fiscal Year: 2010
    ..Thus, the genetic-molecular status of the heart may condition the outcome of aging and genetic manipulations may interfere with the development of the cardiac senescent phenotype in both genders. ..
    William Edmund Sonntag; Fiscal Year: 2013
  39. Gene Networks Regulating Muscle Protein Degradation
    Nathaniel J Szewczyk; Fiscal Year: 2010
  40. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2013
  41. IGF-1, oxidative stress and telomere dynamics in cultured human somatic cells
    Rivka C Stone; Fiscal Year: 2012
    ..Such information will be instrumental in designing preventive and therapeutic modalities to fight aging related diseases. ..
  42. Dietary Patterns, Diet Quality + Cancer Risk
    Frank B Hu; Fiscal Year: 2012
    ..In addition, we will use a novel statistical approach, Reduced Rank Regression (RRR), to develop diet patterns that represent the effect of diet on cancer biomarkers. ..
  43. Regulation of SKN-1 functions by insulin-like signaling in C. elegans
    THOMAS KEITH BLACKWELL; Fiscal Year: 2013
    Shoshana Yakar; Fiscal Year: 2012
  45. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..Should the positive effects of augmented exercise on body composition be supported, we would then anticipate widespread benefit in preventing long-term health consequences of prematurity at relatively low cost. ..
  46. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    Stephen D Hursting; Fiscal Year: 2013
    ..Furthermore, the proposed studies will establish molecular mechanisms underlying the anticancer effects of CR, especially in the putative target cells (i.e., stem cells) for cancer development. ..
  47. The Insulin/IGF-I Axis in Diabetic Osteopathy
    John L Fowlkes; Fiscal Year: 2013
    ..Together, these studies will provide critical mechanistic and pre-clinical information needed to better understand how corrections in insulin and/or IGF-I in diabetes may be beneficial in preventing and treating diabetic osteopathy. ..
  48. Angiotensin II, IGF-1 and Skeletal Muscle Atrophy
    Patrice Delafontaine; Fiscal Year: 2013
    ..These findings will allow development of innovative therapies to treat cachexia in chronic conditions in which the RAS is activated. ..
  49. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
  50. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
    ..The results of the proposed studies will therefore be highly relevant for improving public health, and improving the length and quality of life of millions of patients with ischemic heart disease and heart failure. ..
  51. ENaC Transport in Insulin Resistance: Role of Insulin &IGF-1 Receptors
    Vivek Bhalla; Fiscal Year: 2013
  52. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..The study has the potential to stimulate developments of drugs to ameliorate or prevent acquired muscle weakness. ..
  53. Insulin and IGF-1 regulation of the GnR H neuron
    Sara A DiVall; Fiscal Year: 2012
    ..These studies will provide insight into how the brain's control of reproduction is affected by the nutrition dependent hormones insulin and insulin-like growth factor-1. ..
  54. Novel Strategy for Lung Cancer Treatment Using IGF-1R Inhibitor
    Ho Young Lee; Fiscal Year: 2013
    ..abstract_text> ..
  55. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..These biosensors will be designed to measure oxidized nucleosides, 8-oxodeoxyadenosine and 8-oxodeoxyguanosine, in the DNA of sperm from infertile men. ..
  56. Neuroimmunology and Behavior: Natural Antagonism of Sickness and Depression
    Robert H McCusker; Fiscal Year: 2013
  57. Functional Characterization of CCDC130 Gene
    Deepak Kumar; Fiscal Year: 2012
    ..The proposal may lead to development of a novel cancer biomarker and/or a drug target. The proposal will catalyze PIs transition to non-SCORE funding mechanism and enhance biomedical research at a minority serving institution like UDC. ..
  58. Gene enhanced cartilage repair in a cytokine permissive environment
    Alan J Nixon; Fiscal Year: 2012
    ..Insulin-like growth factor-I (IGF-I) enhances cartilage repair and this grant tests long-term growth factor expression in joints where degradation is controlled by RNA interference. ..
  59. Actions of Parathyroid Hormone (PTH)/PTH Related-Peptide Receptor in Osteocytes
    PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013
    ..Results derived from the studies proposed could have significant implications for therapy of bone disorders such as hyperparathyroidism, osteoporosis and renal osteodystrophy. Thus, its relevance is high for skeletal biology. ..
  60. Short-term estradiol use in middle-age: implications for female cognitive aging
    Jill M Daniel; Fiscal Year: 2013
  61. Notch-1 and IGF-1 crosstalk: new therapeutic strategies for NSCLC
    Maurizio Bocchetta; Fiscal Year: 2013
    ..Furthermore, the study will test the clinical usefulness of targeting Notch signaling to treat NSCLC using GSI. Finally, these experiments will elucidate the role of Notch-1 in lung tumorigenicity in vitro and in vivo. ..
  62. Insulin-Like Growth Factor-1 and Atherosclerosis
    Patrice Delafontaine; Fiscal Year: 2013
    ..These findings should allow development of innovative therapies targeted at reducing acute vascular events that are most often related to plaque instability. ..
  63. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    GREGORY FREUND; Fiscal Year: 2000
    ..Freund has a unique opportunity to develop into an outstanding clinician and scientist. ..
  65. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2007
    ..We will evaluate gene and protein expression of key components of the ubiquitin-proteasome pathway, as outlined in aim #3, as well as markers of signal transduction and outcome measures as outlines in aim #1. ..
    Stanley Fisher; Fiscal Year: 1999
    ..The findings should also contribute to the general understanding of the mechanisms by which ethanol affects the biology of many human tissues, including those of the fetus. ..
    Ralph Meyer; Fiscal Year: 1990
    ..This will permit better treatment of the human disease and improve the quality of life for patients with this common metabolic disorder...
  68. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
    ..These studies will significantly expand knowledge of GH and cytokine signaling and of biologicallyrelevant crosstalk between cytokine and growth factor signaling systems. ..
    ANNE ETGEN; Fiscal Year: 2006
    ..Specific Aim 4 will determine how IGF-1 acutely potentiates a1-adrenoceptor signaling in the HYP-POA of E2-treated females and whether this is important for reproductive behavior. ..
  70. Physiologic Role of the Somatotroph IGF-1 Receptor
    Christopher Romero; Fiscal Year: 2009
    ..In the future, this may provide the basis for guidelines for the evaluation and treatment of children with growth disorders. ..
  71. Prospective evaluation of IGF and IL-6 Dysregulation and Multiple Myeloma
    Graham A Colditz; Fiscal Year: 2010
    ..The team is led from by Drs. Colditz and Anderson and is supported by a senior statistician (Dr. Rosner) and a study director (Dr. Birmann) who is funded, in part, through a K award. ..
    Kelle Moley; Fiscal Year: 2003
    ..Results of this work are expected to have a significant impact on reproductive endocrinology by providing scientific evidence to support new clinical interventions in patients with polycystic ovary syndrome. ..
  73. Growth Hormone & IGF-1 in CNS and Cerebrovascular Aging
    William Edmund Sonntag; Fiscal Year: 2010
  74. Growth Hormone, IGF-1 and Age-related Pathogenesis
    William Sonntag; Fiscal Year: 2003
    ..In addition, the results will provide important information on the potential risks of administration of growth hormone and IGF-l to the elderly. ..