ciliary neurotrophic factor

Summary

Summary: A neurotrophic factor that promotes the survival of various neuronal cell types and may play an important role in the injury response in the nervous system.

Top Publications

  1. pmc Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants
    Paul A Sieving
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3896-901. 2006
  2. doi Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor
    Marco Leibinger
    Department of Experimental Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurosci 29:14334-41. 2009
  3. pmc Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cells
    Wei Xue
    Department of Ophthalmology, Northwestern University Feinberg Medical School, Chicago, Illinois, United States of America
    PLoS ONE 6:e20326. 2011
  4. ncbi AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse
    F Q Liang
    F. M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
    Mol Ther 3:241-8. 2001
  5. ncbi Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
    Weng Tao
    Neurotech USA, Lincoln, Rhode Island 02865, USA
    Invest Ophthalmol Vis Sci 43:3292-8. 2002
  6. ncbi Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor
    L M Herx
    Departments of Clinical Neurosciences and Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 165:2232-9. 2000
  7. ncbi The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells
    T Shimazaki
    Genes and Development Research Group, Department of Cell Biology and Anatomy, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 21:7642-53. 2001
  8. doi Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
    Christian M Simon
    Institute for Clinical Neurobiology, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    Hum Mol Genet 19:973-86. 2010
  9. ncbi Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo
    B A van Adel
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, HSC 1R1, McMaster University, Hamilton, Canada
    J Neurobiol 63:215-34. 2005
  10. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011

Research Grants

Detail Information

Publications255 found, 100 shown here

  1. pmc Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants
    Paul A Sieving
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3896-901. 2006
    ..In this Phase I safety trial, human ciliary neurotrophic factor (CNTF) was delivered by cells transfected with the human CNTF gene and sequestered within capsules that ..
  2. doi Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor
    Marco Leibinger
    Department of Experimental Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurosci 29:14334-41. 2009
    ..Here, we investigated the contribution of glial-derived ciliary neurotrophic factor (CNTF) to LI-mediated regeneration and neuroprotection using wild-type and CNTF-deficient mice...
  3. pmc Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cells
    Wei Xue
    Department of Ophthalmology, Northwestern University Feinberg Medical School, Chicago, Illinois, United States of America
    PLoS ONE 6:e20326. 2011
    b>Ciliary neurotrophic factor (CNTF), a member of the interleukin-6 cytokine family, has been implicated in the development, differentiation and survival of retinal neurons...
  4. ncbi AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse
    F Q Liang
    F. M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
    Mol Ther 3:241-8. 2001
    ..b>Ciliary neurotrophic factor (CNTF) has been shown to promote survival of a number of different neuronal cell types, including ..
  5. ncbi Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
    Weng Tao
    Neurotech USA, Lincoln, Rhode Island 02865, USA
    Invest Ophthalmol Vis Sci 43:3292-8. 2002
    The objective of the present study was to evaluate the therapeutic efficacy of ciliary neurotrophic factor (CNTF) delivered through encapsulated cells directly into the vitreous of the eye in an rcd1 canine model of retinitis pigmentosa...
  6. ncbi Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor
    L M Herx
    Departments of Clinical Neurosciences and Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 165:2232-9. 2000
    ..for CNS-initiated inflammation was addressed by examining the expression of the neurotrophic factor, ciliary neurotrophic factor (CNTF)...
  7. ncbi The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells
    T Shimazaki
    Genes and Development Research Group, Department of Cell Biology and Anatomy, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 21:7642-53. 2001
    The cytokines that signal through the common receptor subunit gp130, including ciliary neurotrophic factor (CNTF), interleukin-6, leukemia inhibitory factor (LIF) and oncostatin M, have pleiotropic functions in CNS development...
  8. doi Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
    Christian M Simon
    Institute for Clinical Neurobiology, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    Hum Mol Genet 19:973-86. 2010
    ..Confocal analysis reveals pronounced sprouting of innervating motor axons. As ciliary neurotrophic factor (CNTF) is highly expressed in Schwann cells, we investigated its role for a compensatory sprouting ..
  9. ncbi Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo
    B A van Adel
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, HSC 1R1, McMaster University, Hamilton, Canada
    J Neurobiol 63:215-34. 2005
    Adenoviral-mediated transfer of ciliary neurotrophic factor (CNTF) to the retina rescued retinal ganglion cells (RGCs) from axotomy-induced apoptosis, presumably via activation of the high affinity CNTF receptor alpha (CNTFRalpha) ..
  10. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011
    To study cone photoreceptor structure and function in patients with inherited retinal degenerations treated with sustained-release ciliary neurotrophic factor (CNTF).
  11. doi Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF
    Adrienne Müller
    Department of Experimental Neurology, University of Ulm, Albert Einstein Alee 11, 89081 Ulm, Germany
    Mol Cell Neurosci 41:233-46. 2009
    ..These data demonstrate that CNTF is a potent axon growth-promoting factor for mature RGCs. However, exogenously applied CNTF stimulates RGCs in vivo partially indirectly via a mechanism that depends on astrocyte-derived CNTF...
  12. pmc CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration
    Yiwen Li
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
    PLoS ONE 5:e9495. 2010
    ..In the present work, we investigated cone degeneration secondary to rod loss in the S334ter-3 transgenic rats carrying the rhodopsin mutation S334ter...
  13. ncbi ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells
    Paul Lingor
    1Department of Neurology, Georg August University Gottingen, University Medicine, Waldweg 33, 37073 Gottingen, Germany
    Brain 131:250-63. 2008
    ..The interaction of intracellular signalling pathways may, however, attenuate more pronounced synergy and has to be taken into account for future treatment strategies...
  14. ncbi AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells
    S G Leaver
    School of Anatomy and Human Biology, The University of Western Australia, Western Australia, Australia
    Gene Ther 13:1328-41. 2006
    ..adeno-associated viral (AAV-2) vectors encoding enhanced green fluorescent protein (GFP) and either ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF) or growth-associated protein-43 (GAP43) on adult ..
  15. pmc SOCS3 deletion promotes optic nerve regeneration in vivo
    Patrice D Smith
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 64:617-23. 2009
    ..Consistently, a transient upregulation of ciliary neurotrophic factor (CNTF) was observed within the retina following optic nerve injury...
  16. ncbi Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons
    Qi Cui
    School of Anatomy and Human Biology, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Mol Cell Neurosci 22:49-61. 2003
    ..b>Ciliary neurotrophic factor increased RGC viability and axonal regrowth, the latter effect substantially enhanced by coapplication ..
  17. ncbi Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease
    L P de Almeida
    Division of Surgical Research and Gene Therapy Center, Lausanne Medical School, Switzerland
    Neurobiol Dis 8:433-46. 2001
    ..further examined with a potential therapeutic gene for the treatment of Huntington's disease, the human ciliary neurotrophic factor (CNTF)...
  18. ncbi Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
    K Yokogami
    Molecular Neuro Oncology, Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Curr Biol 10:47-50. 2000
    Neuropoletic cytokines such as ciliary neurotrophic factor (CNTF) can activate multiple signaling pathways in parallel, including those involving Janus kinase (JAK)-signal transducers and activators of transcription (STATs), mitogen-..
  19. doi Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice
    Peng Yang
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurosci 28:2231-41. 2008
    ..Degeneration of dopaminergic projections in Parkinson's disease and animals reduces, whereas ciliary neurotrophic factor (CNTF) promotes, neurogenesis...
  20. ncbi Regulation of rod phototransduction machinery by ciliary neurotrophic factor
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:13523-30. 2006
    b>Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses...
  21. doi ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Room WX2 17 Institute of Biomedical Research West, Edgbaston, Birmingham, B15 2TT, UK
    Mol Cell Neurosci 42:128-33. 2009
    ..model to show that Y27632 only promotes disinhibited neurite outgrowth if RGC are co-stimulated with ciliary neurotrophic factor (CNTF)...
  22. doi Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve
    Vincent Pernet
    Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neurobiol Dis 51:202-13. 2013
    ..The infection of retinal ganglion cells (RGCs) with an adeno-associated virus serotype 2 - ciliary neurotrophic factor (AAV2.CNTF) was previously shown to stimulate axonal regeneration...
  23. doi Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons
    Kazunori Sango
    Division of Neural Development and Regeneration, Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Histochem Cell Biol 130:669-79. 2008
    We observed that recombinant ciliary neurotrophic factor (CNTF) enhanced survival and neurite outgrowth of cultured adult rat dorsal root ganglion (DRG) neurons...
  24. doi Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling
    Stephan Müller
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Stem Cells 27:431-41. 2009
    ..The gp130-associated cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) have been implicated in regulating NSC self-renewal and ..
  25. pmc Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
    I Gloaguen
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Via Pontina Km 30 600, 00040 Pomezia, Rome, Italy
    Proc Natl Acad Sci U S A 94:6456-61. 1997
    Receptor subunits for the neurocytokine ciliary neurotrophic factor (CNTF) share sequence similarity with the receptor for leptin, an adipocyte-derived cytokine involved in body weight homeostasis...
  26. doi Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis
    Luiz F Rezende
    Department of Physiology and Biophysics, State University of Campinas, Brazil
    Cytokine 46:65-71. 2009
    ..These findings indicate that CNTF may be a potential therapeutic tool against Type 1 and/or Type 2 diabetes...
  27. ncbi Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
    M Sendtner
    Department of Neurochemistry, Max Planck Institute for Psychiatry, Martinsried, Germany
    Nature 358:502-4. 1992
    b>Ciliary neurotrophic factor (CNTF) supports the survival of embryonic motor neurons in vitro and in vivo, and prevents lesion-mediated degeneration of rat motor neurons during early post-natal stages...
  28. pmc Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration
    Kang Zhang
    Shiley Eye Center and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:6241-5. 2011
    ..In a pilot, proof of concept phase 2 study, we evaluated ciliary neurotrophic factor (CNTF) delivered via an intraocular encapsulated cell technology implant for the treatment of GA...
  29. ncbi Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF
    M Sendtner
    Department of Neurology, University of Wurzburg, Germany
    Curr Biol 6:686-94. 1996
    ..The multifactorial support of motoneurons represents a system of high security, because the inactivation of individual ligands has either no detectable, or relatively small, atrophic or degenerative effect on motoneurons...
  30. pmc Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neurosci 30:2989-3001. 2010
    ..b>Ciliary neurotrophic factor (CNTF) was the most effective neurotrophic factor to promote oligodendrocyte (OL) differentiation and ..
  31. ncbi Activation of GABA(A) receptors facilitates astroglial differentiation induced by ciliary neurotrophic factor in neural progenitors isolated from fetal rat brain
    Masanori Yoneyama
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Neurochem 100:1667-79. 2007
    ..facilitated the subsequent expression of an astroglial marker protein in cells differentiated by ciliary neurotrophic factor (CNTF) toward an astroglial lineage, with a concomitant decrease in the neuronal marker protein ..
  32. ncbi Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration
    F C Schlichtenbrede
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, UK
    Gene Ther 10:523-7. 2003
    ..The most commonly studied factor, ciliary neurotrophic factor (CNTF), has been shown to preserve retinal morphology and to promote cell survival in a variety of ..
  33. ncbi Upregulation of ciliary neurotrophic factor in reactive Müller cells in the rat retina following optic nerve transection
    M H Chun
    Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, 137 701, Seoul, South Korea
    Brain Res 868:358-62. 2000
    We have investigated the expression and cellular localization of ciliary neurotrophic factor (CNTF) in the rat retina following optic nerve transection...
  34. ncbi Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation
    Dean Bok
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Exp Eye Res 74:719-35. 2002
    Past studies have shown that acute administration of ciliary neurotrophic factor (CNTF) can prolong the survival of retinal photoreceptor cells that have undergone phototoxic injury or that express gene mutations...
  35. ncbi Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia
    W M Peterson
    Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
    J Neurosci 20:4081-90. 2000
    b>Ciliary neurotrophic factor (CNTF) is pleiotrophic for central, peripheral, and sensory neurons. In the mature retina, CNTF treatment enhances survival of retinal ganglion and photoreceptor cells exposed to otherwise lethal perturbation...
  36. pmc Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer
    Jakob Vejby Larsen
    MIND Center, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark
    Mol Cell Biol 30:4175-87. 2010
    ..Here we report that ciliary neurotrophic factor (CNTF), and related ligands targeting the established CNTF receptor alpha, binds to sortilin with high ..
  37. ncbi Ciliary neurotrophic factor is an early lesion-induced retrograde signal for axotomized facial motoneurons
    Matthias Kirsch
    Institute of Anatomy, University of Freiburg, P O Box 111, D 79001 Freiburg, Germany
    Mol Cell Neurosci 24:130-8. 2003
    ..Other cytokines like leukemia inhibitory factor obviously become active at later time points...
  38. doi Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retina
    Kevin K Park
    School of Anatomy and Human Biology M309, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Mol Cell Neurosci 41:313-24. 2009
    ..Survival and regeneration of RGCs is increased by intraocular injections of ciliary neurotrophic factor (CNTF) and axonal regeneration is further enhanced by co-injection of a cyclic AMP analogue (CPT-cAMP)...
  39. pmc Function and mechanism of CNTF/LIF signaling in retinogenesis
    Kun Do Rhee
    University of California, Los Angeles, CA, USA
    Adv Exp Med Biol 664:647-54. 2010
    b>Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) exhibit multiple biological effects in the developing vertebrate retina...
  40. ncbi Purification, cloning, and expression of ciliary neurotrophic factor (CNTF)
    L F Lin
    Protein Chemistry Group, Synergen, Inc, Boulder, CO 80301
    Science 246:1023-5. 1989
    b>Ciliary neurotrophic factor (CNTF) is one of a small number of proteins with neurotrophic activities distinct from nerve growth factor (NGF)...
  41. ncbi Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa
    F Q Liang
    F. M. Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 4:461-72. 2001
    ..aimed to determine whether intravitreal administration of an adeno-associated virus (AAV) carrying ciliary neurotrophic factor (CNTF) can achieve long-term morphological and physiological rescue of photoreceptors in animal models ..
  42. ncbi Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration
    Takayuki Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502
    J Neurosci 22:9228-36. 2002
    ..photoreceptor layer and alter expression of neurotrophic factors such as nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), and glial cell line-derived neurotrophic factor (GDNF)...
  43. ncbi Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice
    Diana Zala
    Institute of Neuroscience, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
    Exp Neurol 185:26-35. 2004
    b>Ciliary neurotrophic factor (CNTF) has been shown to prevent behavioral deficits and striatal degeneration in neurotoxic models of Huntington's disease (HD), but its effect in a genetic model has not been evaluated...
  44. doi Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys
    Thomas G Hauk
    Department of Experimental Neurology, University of Ulm, Ulm, Germany
    Invest Ophthalmol Vis Sci 51:459-64. 2010
    ....
  45. doi Effects of interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor on the proliferation and differentiation of adult human myoblasts
    Xuan Wang
    Department of Physiology, Capital Medical University, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, 10 You An Men, Fengtai District, Beijing, 100069, P R China
    Cell Mol Neurobiol 28:113-24. 2008
    Our previous studies have demonstrated that ciliary neurotrophic factor, a member of the interleukin-6-type cytokine superfamily, could inhibit the differentiation of myoblasts into mature myotubes at a certain concentration...
  46. ncbi Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients
    Ranjan Dutta
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Brain 130:2566-76. 2007
    ..67 transcripts increased in MS cortex nine were related to the signalling mediated by the neurotrophin ciliary neurotrophic factor (CNTF)...
  47. ncbi Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
    San Pun
    Friedrich Miescher Institut, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Neurosci 9:408-19. 2006
    ..It is alleviated by ciliary neurotrophic factor and triggers proteasome-dependent pruning of peripheral axon branches...
  48. ncbi Requirement of serine phosphorylation for formation of STAT-promoter complexes
    X Zhang
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 267:1990-4. 1995
    ..DNA complex formation was inversely correlated with the affinity of Stat3-Stat3 for the binding site. Thus, serine phosphorylation appears to enhance or to be required for the formation of stable Stat3-Stat3.DNA complexes...
  49. ncbi CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
    N Y Ip
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Cell 69:1121-32. 1992
    b>Ciliary neurotrophic factor (CNTF) has a variety of actions within the nervous system...
  50. pmc Nuclear factor-kappaB activation via tyrosine phosphorylation of inhibitor kappaB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons
    Denis Gallagher
    School of Biosciences, Cardiff CF10 3US, United Kingdom
    J Neurosci 27:9664-9. 2007
    The cytokine ciliary neurotrophic factor (CNTF) promotes the growth of neural processes from many kinds of neurons in the developing and regenerating adult nervous system, but the intracellular signaling mechanisms mediating this ..
  51. doi Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease
    Pierre Garcia
    JE2482 Lipidomix, Nancy Universite, Vandoeuvre, France
    J Neurosci 30:7516-27. 2010
    ..We aimed to determine whether the loco-regional delivery of ciliary neurotrophic factor (CNTF) could prevent amyloid-beta (Abeta) oligomer-induced synaptic damages and associated cognitive ..
  52. ncbi The ciliary neurotrophic factor and its receptor, CNTFR alpha
    M W Sleeman
    Regeneron Pharmaceuticals, Tarrytown, NY 10591 6707, USA
    Pharm Acta Helv 74:265-72. 2000
    b>Ciliary neurotrophic factor (CNTF) is expressed in glial cells within the central and peripheral nervous systems...
  53. ncbi Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice
    M Sendtner
    Clinical Research Unit for Neuroregeneration, Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Neurosci 17:6999-7006. 1997
    b>Ciliary neurotrophic factor (CNTF) is an abundant cytosolic molecule in myelinating Schwann cells of adult rodents...
  54. ncbi Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time
    Brian A van Adel
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, L8N 3ZS, Canada
    Hum Gene Ther 14:103-15. 2003
    b>Ciliary neurotrophic factor (CNTF) has recently been demonstrated to be one of the most promising neurotrophic factors to improve both the survival and regeneration of injured retinal ganglion cells (RGCs)...
  55. ncbi Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse
    M Cayouette
    Laboratoire de Transfert de Gènes, Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada, G1J 2G3
    J Neurosci 18:9282-93. 1998
    ..Here, we report that intraocular adenovirus-mediated gene transfer of ciliary neurotrophic factor (CNTF) in this mutant reduces photoreceptor loss, causes a significant increase in the length of ..
  56. doi Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats
    Richa B Tripathi
    Neuroscience Graduate Studies Program and Department of Neuroscience, Center for Brain and Spinal Cord Repair, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Comp Neurol 510:129-44. 2008
    ..Here, we examined ciliary neurotrophic factor (CNTF) and fibroblast growth factor-2 (FGF-2) expression, because both factors alter progenitor ..
  57. ncbi Cellular and subcellular patterns of expression of bFGF and CNTF in the normal and light stressed adult rat retina
    N Walsh
    NSW Retinal Dystrophy Research Centre, Department of Anatomy and Histology, University of Sydney, NSW 2006, Australia
    Exp Eye Res 72:495-501. 2001
    ..stressed rat retina of the neuroprotective factors bFGF (basic fibroblast growth factor) and CNTF (ciliary neurotrophic factor)...
  58. pmc Effect of CNTF on retinal ganglion cell survival in experimental glaucoma
    Mary Ellen Pease
    Department of Ophthalmology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, 175 Woods Research Building, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 50:2194-200. 2009
    ..To assess the neuroprotective effect of virally mediated overexpression of ciliary-derived neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in experimental rat glaucoma...
  59. doi CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 613:407-13. 2008
  60. ncbi Relation of weight maintenance and dietary restraint to peroxisome proliferator-activated receptor gamma2, glucocorticoid receptor, and ciliary neurotrophic factor polymorphisms
    Neeltje Vogels
    Departments of Human Biology and Methodology and Statistics, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 82:740-6. 2005
    Genetic variation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2), glucocorticoid receptor (GRL), and ciliary neurotrophic factor (CNTF) genes may play a role in the etiology of obesity.
  61. doi A putative physiological role of hypothalamic CNTF in the control of energy homeostasis
    C M Vacher
    Laboratoire de Neuroendocrinologie Moléculaire de la Prise Alimentaire, UMR 1197 INRA, Université Paris 11, Bâtiment 447, 91405 Orsay, France
    FEBS Lett 582:3832-8. 2008
    ..Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity...
  62. ncbi Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology
    Ronald A Bush
    Department of Ophthalmology and Visual Science, Kellogg Eye Center, University of Michigan, Ann Arbor, USA
    Invest Ophthalmol Vis Sci 45:2420-30. 2004
    ERG and histologic changes were investigated in normal rabbits after intravitreal implantation of encapsulated cell technology (ECT) devices releasing ciliary neurotrophic factor (CNTF).
  63. ncbi Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Brain Res 1061:97-106. 2005
    ..In contrast, ciliary neurotrophic factor (CNTF) administration increased the peak level of RB3 mRNA induction significantly at 3 days after ..
  64. ncbi Ciliary neurotrophic factor (CNTF) in combination with its soluble receptor (CNTFRalpha) increases connexin43 expression and suppresses growth of C6 glioma cells
    Mark A Ozog
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, N6A 5C1, Canada
    Cancer Res 62:3544-8. 2002
    ..The purpose of this study was to determine whether ciliary neurotrophic factor (CNTF) can be used to increase endogenous connexin43 levels, increase intercellular coupling, and ..
  65. pmc Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
    Ben Emery
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:7859-64. 2006
    ..These results indicate that modulation of SOCS3 expression could facilitate the endogenous response to CNS injury...
  66. ncbi Neurotrophic factors in Huntington's disease
    Jordi Alberch
    Department of Cell Biology and Pathology, Medical School, IDIBAPS, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Prog Brain Res 146:195-229. 2004
    ..Neurotrophins, glial cell line-derived neurotrophic factor family members and ciliary neurotrophic factor have shown a potent neuroprotective effects on different neuronal populations of the striatum...
  67. ncbi Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, USA
    J Am Geriatr Soc 54:823-6. 2006
    To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women.
  68. ncbi Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study
    J Bloch
    Swiss Federal Institute of Technology Lausanne, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Hum Gene Ther 15:968-75. 2004
    ..Proteins with neuroprotective effects in the adult brain have been identified, among them ciliary neurotrophic factor (CNTF), which protected striatal neurons in animal models of HD...
  69. ncbi Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats
    Yoshinori Aizu
    Research and Development Center, BML, 1361 1 Matoba, Kawagoe City, Saitama 350 1101, Japan
    Neuroreport 14:2067-71. 2003
    Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains...
  70. ncbi CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06510, USA
    Exp Eye Res 82:395-404. 2006
    b>Ciliary neurotrophic factor (CNTF) provides morphologic preservation of rods in several animal models of retinitis pigmentosa (RP)...
  71. ncbi Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus in response to kainic acid-induced excitotoxicity
    Jeong Sun Choi
    Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    Mol Cells 17:292-6. 2004
    We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following intraperitoneal administration of a convulsant dose of kainic acid (KA)...
  72. ncbi Gene expression in arcuate nucleus-median eminence of rats treated with leptin or ciliary neurotrophic factor
    Suresh Ambati
    Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602 2771, USA
    Biofactors 31:133-44. 2007
    b>Ciliary neurotrophic factor (CNTF) and leptin are cytokine-like% hormones and act on their corresponding receptors in the hypothalamic arcuate nucleus (ARC)...
  73. doi Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice
    Eileen M Denovan-Wright
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurosci Res 86:1748-57. 2008
    ..b>Ciliary neurotrophic factor (CNTF) has been shown to protect neurons against chemically induced toxic insults in vitro and in vivo...
  74. doi Trophic responsiveness of purified postnatal and adult rat retinal ganglion cells
    Chi Him Eddie Ma
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 Building, 13th Street, Room 4309, Charlestown, MA 02129, USA
    Cell Tissue Res 339:297-310. 2010
    ..by long-term survival (30 days) in medium contained brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and forskolin (F) (BCF)...
  75. doi Identification and expression analysis of two fish-specific IL-6 cytokine family members, the ciliary neurotrophic factor (CNTF)-like and M17 genes, in rainbow trout Oncorhynchus mykiss
    Tiehui Wang
    Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mol Immunol 46:2290-8. 2009
    ..These results suggest a major role of the CNTF-like molecule in fish nervous and muscular systems and of M17 in the immune system...
  76. ncbi Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection
    A C S Rezende
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil
    Braz J Med Biol Res 41:1024-8. 2008
    b>Ciliary neurotrophic factor (CNTF) is a cytokine that plays a neuroprotective role in relation to axotomized motoneurons. We determined the effect of daily subcutaneous doses of CNTF (1...
  77. ncbi IAP family proteins delay motoneuron cell death in vivo
    D Perrelet
    Division Clinical Neuromuscular Research and Department of APSIC, Faculty of Medicine, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Eur J Neurosci 12:2059-67. 2000
    ..The efficiency of these proteins was similar to that of two neurotrophic factors, ciliary neurotrophic factor and brain-derived neurotrophic factor, administrated by the same viral technique...
  78. doi Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors
    Francisco J Rivera
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neurochem 107:832-43. 2008
    ..Here, we hypothesized that ciliary neurotrophic factor might be a candidate for this activity, since (i) it is expressed by mesenchymal stem cells and (ii) it ..
  79. doi Role of ciliary neurotrophic factor in microglial phagocytosis
    Tsung I Lee
    Department of Life Sciences, National Cheng Kung University, Tainan City, 70101, Taiwan
    Neurochem Res 34:109-17. 2009
    ..In the present study, ciliary neurotrophic factor (CNTF), which has been reported to be produced by glia, was shown to have stimulatory effect on the ..
  80. pmc Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons
    L A Tebar
    National Centre for Cancer Research, Melchor Fernandez Almagro, 3 E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:11400-5. 2008
    ..is both an obligatory intermediate in the downstream signaling of the leukemia inhibitory factor/ciliary neurotrophic factor (CNTF) family of cytokines, maintaining the integrity of motor neurons during development, as well as a ..
  81. ncbi [Bone marrow stromal cells transfected with ciliary neurotrophic factor gene ameliorates the symptoms and inflammation in C57BL/6 mice with experimental allergic encephalomyelitis]
    Zheng Qi Lu
    Department of Neurology, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2355-61. 2009
    To investigate the anti-inflammatory effect of bone marrow stromal cells (MSCs) transfected with recombinant adenovirus-mediated ciliary neurotrophic factor (CNTF) gene in C57BL/6 mice with experimental allergic encephalomyelitis (EAE).
  82. doi The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons
    Odile Couvreur
    Neuroendocrinologie Moléculaire de la Prise Alimentaire, University of Paris Sud, Orsay, France
    Am J Physiol Endocrinol Metab 302:E458-67. 2012
    b>Ciliary neurotrophic factor (CNTF) is a neural cytokine that reduces appetite and body weight when administrated to rodents or humans...
  83. doi The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats
    Jiani Cao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    Biomaterials 32:3939-48. 2011
    ..b>Ciliary neurotrophic factor (CNTF) plays a critical role in peripheral nerve regeneration...
  84. pmc Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
    BMC Neurosci 12:58. 2011
    ..to send a sprout is controversial and may be controlled by cytokines and/or neurotrophic factors like ciliary neurotrophic factor (CNTF)...
  85. pmc Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
    K A Stöckli
    Max Planck Institute for Psychiatry, Department of Neurochemistry, Planegg Martinsried, Germany
    J Cell Biol 115:447-59. 1991
    b>Ciliary neurotrophic factor (CNTF) is a potent survival molecule for a variety of embryonic neurons in culture...
  86. ncbi The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
    H Mitsumoto
    Department of Neurology, Cleveland Clinic Foundation, OH
    Ann Neurol 36:142-8. 1994
    b>Ciliary neurotrophic factor is the first neurotrophic factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo...
  87. ncbi The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
    A Symes
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Biol 7:697-700. 1997
    b>Ciliary neurotrophic factor, along with other neuropoietic cytokines, signals through the shared receptor subunit gp130 [1-3], leading to the tyrosine phosphorylation of a number of substrates [4,5], including the transcription factors ..
  88. pmc Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain
    Francois Rousseau
    Unité Mixte INSERM 564, Bâtiment Montéclair, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Biol Chem 283:30341-50. 2008
    b>Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin are members of the four-helix bundle cytokine family...
  89. ncbi Endogenous and exogenous ciliary neurotrophic factor enhances forebrain neurogenesis in adult mice
    J G Emsley
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Neurol 183:298-310. 2003
    ..The receptor for ciliary neurotrophic factor (CNTF), CNTFRalpha, is expressed in the adult subventricular zone...
  90. ncbi Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor
    Pia März
    Department of Physiology, University of Basel, Switzerland
    Eur J Biochem 269:3023-31. 2002
    b>Ciliary neurotrophic factor (CNTF) displays neurotrophic activities on motor neurons and neural cell populations both in vivo and in vitro...
  91. ncbi Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina
    Vimal Sarup
    Department of Ophthalmology and Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Brain Res 1013:152-8. 2004
    b>Ciliary neurotrophic factor (CNTF) has been implicated in the survival and regeneration of adult rat retinal ganglion cells (RGCs)...
  92. ncbi The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes
    Sanjin Zvonic
    Department of Biological Sciences, Louisiana State University, Baton Rouge 70803, USA
    J Biol Chem 278:2228-35. 2003
    b>Ciliary neurotrophic factor (CNTF) is primarily known for its roles as a lesion factor released by the ruptured glial cells that prevent neuronal degeneration...
  93. ncbi Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
    K A Stöckli
    Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg Martinsried, FRG
    Nature 342:920-3. 1989
    b>Ciliary neurotrophic factor (CNTF) was originally characterized as a survival factor for chick ciliary neurons in vitro...
  94. ncbi A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway
    W J Young
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Biochemistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 273:20877-85. 1998
    ..that the nuclear orphan receptor TR4 could induce transcriptional activity via the 5th intron of the ciliary neurotrophic factor (CNTF) alpha receptor gene (CNTFR-I5)...
  95. ncbi Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina
    R Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    Curr Eye Res 17:494-500. 1998
    ..To examine mRNA expression of neurotrophic factors in the retina after exposure to bright light...
  96. doi Ciliary neurotrophic factor: a survival and differentiation inducer in human retinal progenitors
    Kamla Dutt
    Department of Pathology, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, GA 30310 1495, USA
    In Vitro Cell Dev Biol Anim 46:635-46. 2010
    ..One of the neurotrophins with promise is the ciliary neurotrophic factor (CNTF)...
  97. ncbi Location of CNTFRalpha on outer segments: evidence of the site of action of CNTF in rat retina
    Krisztina Valter
    CNS Stability and Degeneration Group, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia
    Brain Res 985:169-75. 2003
    b>Ciliary neurotrophic factor (CNTF) is an important factor in the retina's mechanisms of self-protection. It is generated by retinal glial cells in response to stress, and has a significant protective effect on retinal neurones...
  98. ncbi The effects of ciliary neurotrophic factor on neurological function and glial activity following contusive spinal cord injury in the rats
    Junli Ye
    Department of Neurobiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Brain Res 997:30-9. 2004
    b>Ciliary neurotrophic factor (CNTF) has been implicated in the pathophysiology of injury to the central nervous system...
  99. pmc Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro
    Xiaoping Chen
    Department of Neurophysiology, Institute of Basic Medical Sciences, Beijing 100850, China
    Mol Biol Cell 16:3140-51. 2005
    b>Ciliary neurotrophic factor (CNTF) is primarily known for its important cellular effects within the nervous system. However, recent studies indicate that its receptor can be highly expressed in denervated skeletal muscle...
  100. ncbi CNTF genotype is associated with muscular strength and quality in humans across the adult age span
    S M Roth
    Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park 20742, Maryland, USA
    J Appl Physiol 90:1205-10. 2001
    The relationship between ciliary neurotrophic factor (CNTF) genotype and muscle strength was examined in 494 healthy men and women across the entire adult age span (20-90 yr)...
  101. pmc Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
    William A Beltran
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 84:753-71. 2007
    b>Ciliary neurotrophic factor (CNTF) rescues photoreceptors in several animal models of retinal degeneration and is currently being evaluated as a potential treatment for retinitis pigmentosa in humans...

Research Grants81

  1. Aminosterol MSI-1436 as a Therapeutic for Obesity
    Michael McLane; Fiscal Year: 2004
    ..led to potential therapeutic agents with novel activities, such as leptin, ghrelin antagonists, and ciliary neurotrophic factor (CNTF)...
  2. Cytokine Regulation of Photoreceptor Gene Expression
    John Ash; Fiscal Year: 2009
    ..The broad-spectrum protective activity of leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) have a clear therapeutic advantage when the genetic mutation or environmental factors are ..
  3. CNTF Receptors: Neuromuscular Protection/Repair In Vivo
    Alexander MacLennan; Fiscal Year: 2007
    Several lines of evidence suggest that endogenous ciliary neurotrophic factor (CNTF) receptor signaling may promote neuromuscular protection and repair...
  4. CNTF Receptors: Neuromuscular Protection/Repair In Vivo
    Alexander MacLennan; Fiscal Year: 2009
    Several lines of evidence suggest that endogenous ciliary neurotrophic factor (CNTF) receptor signaling may promote neuromuscular protection and repair...
  5. CYTOKINE SIGNAL TRANSDUCTION IN RETINAL DEVELOPMENT
    Xian Jie Yang; Fiscal Year: 2004
    ..The proposed study focuses on the cytokine-signaling pathway in the mouse retina. Ciliary neurotrophic factor (CNTF), a member of the cytokine superfamily, has a variety of effects on neuronal development and ..
  6. GENE EFFECTS ON STRENGTH RESPONSES TO AGE AND EXERCISE
    Bernard Hurley; Fiscal Year: 2005
    ..In a recent pilot study, we observed that a common polymorphism at the ciliary neurotrophic factor (CNTF) gene locus was a significant predictor of age-associated strength levels and that a common ..
  7. GENE DELIVERY FOR SPIRAL CORD INJURY REPAIR
    H Shine; Fiscal Year: 2004
    ..Genes for neurotrophin 3 (NT-3), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF) and glial cell line-derived growth factor (GDNF) will ..
  8. REGULATION OF POSTNATAL CORTICAL MULTIPOTENT PROGENITORS
    MARK MEHLER; Fiscal Year: 2002
    ..promotes the expansion of oligodendrocyte progenitors that require additional environmental signals (ciliary neurotrophic factor, CNTF) for oligodendrocyte differentiation...
  9. Endogenous CNTF receptors and adult, in vivo neurogenesis
    ALEXANDER JOHN MACLENNAN; Fiscal Year: 2010
    ..Indirect data suggest, and we hypothesize, that endogenous ciliary neurotrophic factor (CNTF) receptor signaling inhibits the neuronal differentiation of NSP cells...
  10. ETHANOL AND JAK-STAT SIGNALING PATHWAY
    Edward Ishac; Fiscal Year: 2002
    ..6-induced STAT activation in hematopoietic cells (BAF3/mp1 cells, platelets, U937, and AF10 cells), and ciliary neurotrophic factor-induced STAT activation in neuronal cells (NBTF neuroblastoma)...
  11. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..However brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor, the two most widely used factors, do not act on the photoreceptors directly, but indirectly through ..
  12. Signaling pathways directing cholinergic gene expression
    Brygida Berse; Fiscal Year: 2004
    ..stimuli, in particular by two groups of neurotrophins: the cytokines of the leukemia inhibitory factor/ciliary neurotrophic factor (LIF/CNTF) family, and nerve growth factor (NGF)...
  13. The Glucoregulatory and Liporegulatory Peptide Hormones
    Roger Unger; Fiscal Year: 2004
    ..complications that result from fat accumulation in vital organs; 3) the relationship between leptin and ciliary neurotrophic factor (CNTF), a leptin-like hormone produced in brain and other tissues, including the pancreatic islets; and ..
  14. Targeting CNTF to increase adult forebrain neurogenesis
    Theo Hagg; Fiscal Year: 2010
    ..We have shown that endogenous and injected ciliary neurotrophic factor (CNTF) promotes neurogenesis in the adult mouse subventricular zone in the adult mouse forebrain (SVZ)...