interleukins

Summary

Summary: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.

Top Publications

  1. ncbi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
  2. ncbi Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
  3. ncbi Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Genet 41:1105-9. 2009
  4. ncbi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
  5. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  6. ncbi Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 139:499-509. 2010
  7. ncbi Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Gastroenterology 138:1338-45, 1345.e1-7. 2010
  8. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
  9. ncbi IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    Thomas J Urban
    Center for Human Genome Variation, Duke University Medical Center, Durham, NC, USA
    Hepatology 52:1888-96. 2010
  10. ncbi An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    Alessandra Mangia
    Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Gastroenterology 139:821-7, 827.e1. 2010

Research Grants

  1. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
  2. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
  3. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
  4. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
  5. Gene Polymorphism, Infection/Inflammation, Preterm Birth
    Xiaobin Wang; Fiscal Year: 2010
  6. Functional cloning of S. mansoni egg-specific Th2 cells
    Markus Mohrs; Fiscal Year: 2007
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
  8. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
  9. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  10. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005

Detail Information

Publications196 found, 100 shown here

  1. ncbi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
    ....
  2. ncbi Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
    ..To our knowledge, this is the strongest and most significant genetic effect associated with natural clearance of HCV, and these results implicate a primary role for IL28B in resolution of HCV infection...
  3. ncbi Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Genet 41:1105-9. 2009
    ..52 x 10(-28)-2.68 x 10(-32); OR = 22.3-27.1). Real-time quantitative PCR assays in peripheral blood mononuclear cells showed lower IL28B expression levels in individuals carrying the minor alleles (P = 0.015)...
  4. ncbi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
    ..These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha...
  5. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  6. ncbi Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 139:499-509. 2010
    ..Multiple viral and host factors are related to the treatment response to pegylated-interferon and ribavirin combination therapy; however, the clinical relevance and relationship of these factors have not yet been fully evaluated...
  7. ncbi Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Gastroenterology 138:1338-45, 1345.e1-7. 2010
    ..We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy...
  8. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  9. ncbi IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    Thomas J Urban
    Center for Human Genome Variation, Duke University Medical Center, Durham, NC, USA
    Hepatology 52:1888-96. 2010
    ..IL28B-type was not associated with intrahepatic IL28B messenger RNA expression in vivo. Further investigation of the precise molecular mechanism(s) by which IL28B genetic variation influences HCV outcomes is warranted...
  10. ncbi An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    Alessandra Mangia
    Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Gastroenterology 139:821-7, 827.e1. 2010
    ..We evaluated the effects of IL-28B polymorphisms on response to treatment with peginterferon and ribavirin in a well-characterized cohort of genotype 2/3 patients...
  11. ncbi Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    Heather R Conti
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
    J Exp Med 206:299-311. 2009
    ..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
  12. ncbi TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    Ahjoku Amadi Obi
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 13:711-8. 2007
    ....
  13. ncbi Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    Tobias Marcello
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    Gastroenterology 131:1887-98. 2006
    ..CONCLUSIONS: These results demonstrate distinct differences in IFN-lambda- and IFN-alpha-induced antiviral states. Understanding these differences may prove useful for developing new HCV treatment strategies...
  14. ncbi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
    ..We sought to confirm the polymorphism's clinical relevance by intention-to-treat analysis evaluating on-treatment virologic response and SVR...
  15. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
  16. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  17. ncbi Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    Caroline E Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 31:331-41. 2009
    ..Our findings demonstrate that gammadelta T cells activated by IL-1beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation...
  18. ncbi A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
    ....
  19. ncbi IL-23 promotes tumour incidence and growth
    John L Langowski
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
    Nature 442:461-5. 2006
    ..We show that IL-23 is an important molecular link between tumour-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumours...
  20. ncbi RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    Stephanie L Sanos
    Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Nat Immunol 10:83-91. 2009
    ..IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis...
  21. ncbi Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypes
    Marco Antonio Montes-Cano
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio Instituto de Biomedicina de Sevilla, Sevilla, Spain
    Hepatology 52:33-7. 2010
    ..1 x 10(-5), OR = 0.31; 95%CI, 0.17-0.56). CONCLUSION: We have found different rates of viral genotype infection depending on the IL28B variant as well as an association of this locus with natural and treatment-mediated response...
  22. ncbi Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
    Franck J D Mennechet
    Centre National de la Recherche Scientifique Unité mixte de recherche 5124, University of Montpellier, Place Eugene Bataillon 34095, Montpellier Cedex 5, France
    Blood 107:4417-23. 2006
    ..IFN-lambdas are thus able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions...
  23. ncbi Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  24. ncbi Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    Daniel R Neill
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 464:1367-70. 2010
    ..Thus, nuocytes represent a critically important innate effector cell in type-2 immunity...
  25. ncbi Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    Jeanette J McCarthy
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27708, USA
    Gastroenterology 138:2307-14. 2010
    ..We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients...
  26. ncbi IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..Using passive transfer studies, we confirm that these IL-23-dependent CD4(+) T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity...
  27. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  28. ncbi Interleukin-33 - cytokine of dual function or novel alarmin?
    Guttorm Haraldsen
    Division of Pathology, Oslo University Hospital, 0027 Oslo, Norway
    Trends Immunol 30:227-33. 2009
    ....
  29. ncbi IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells
    Molly D Smithgall
    Department of Inflammation Research, Amgen Inc, 1201 Amgen Court West, Seattle, WA, USA
    Int Immunol 20:1019-30. 2008
    ..Moreover, the nature of the responses elicited by IL-33 suggests that this axis may amplify both T(h)1- and T(h)2-oriented immune responses...
  30. ncbi IL-28, IL-29 and their class II cytokine receptor IL-28R
    Paul Sheppard
    ZymoGenetics, Inc, 1201 Eastlake Avenue E, Seattle, WA 98102, USA
    Nat Immunol 4:63-8. 2003
    ..This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection...
  31. ncbi Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
    Alexander U Lüthi
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    Immunity 31:84-98. 2009
    ..Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33...
  32. ncbi Interleukin-12 and the regulation of innate resistance and adaptive immunity
    Giorgio Trinchieri
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
    Nat Rev Immunol 3:133-46. 2003
    ....
  33. ncbi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  34. ncbi Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
    ..Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair...
  35. ncbi IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    Ken Sugimoto
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 118:534-44. 2008
    ..These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene-delivery system for treating UC...
  36. ncbi Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 206:43-9. 2009
    ....
  37. ncbi The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    Beichu Guo
    Department of Microbiology, Immunology, and Molecular Genetics, 8 240 Factor Building, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Clin Invest 118:1680-90. 2008
    ....
  38. ncbi The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    Corinne Cayrol
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, F 31077 Toulouse, France
    Proc Natl Acad Sci U S A 106:9021-6. 2009
    ..We speculate that IL-33 may function, similarly to the prototypical alarmins HMGB1 and IL-1alpha, as an endogenous danger signal to alert cells of the innate immune system of tissue damage during trauma or infection...
  39. ncbi Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    Caroline Pot
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 183:797-801. 2009
    ..ICOS further promotes IL-27-driven Tr1 cells. Each of those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency of IL-27-induced differentiation of IL-10-producing Tr1 cells...
  40. ncbi Biology of interleukin-22
    Kerstin Wolk
    University Hospital Charite, Berlin, Germany
    Semin Immunopathol 32:17-31. 2010
    ....
  41. ncbi IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
    Mariola Kurowska-Stolarska
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 183:6469-77. 2009
    ..Taken together, we demonstrate here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation...
  42. ncbi Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
    Sean E Doyle
    ZymoGenetics, Inc, Seattle, WA 98102, USA
    Hepatology 44:896-906. 2006
    ..This fact, combined with significant receptor expression in hepatitis virus-infected livers, suggests that IL-29 may have therapeutic value against chronic viral hepatitis in human patients...
  43. ncbi Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro
    Shekar Srinivas
    The Institute for Genetic Immunology, Hamilton, NJ 08690, USA
    Immunology 125:492-502. 2008
    ..Thus, IFN-lambda1 appears to be an inhibitor of human Th2 responses whose action is primarily directed towards IL-13 but which may also affect Th2 responses generally and does not invoke a complementary elevation of IFN-gamma secretion...
  44. ncbi IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    Katia Boniface
    Laboratoire Cytokines et Inflammation, UPRES EA 3806, , , Poitiers, France
    J Immunol 174:3695-702. 2005
    ..Finally, we show that IL-22 strongly induces hyperplasia of reconstituted human epidermis. Taken together, these results suggest that IL-22 plays an important role in skin inflammatory processes and wound healing...
  45. ncbi Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses
    Mingcai Li
    Institute of Inflammation and Immune Diseases, Shantou University Medical College, Shantou, China
    J Leukoc Biol 86:23-32. 2009
    ..In this review, we summarize recent findings about the biology of IFN-lambdas and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms...
  46. ncbi Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Daniel J Cua
    Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
    Nature 421:744-8. 2003
    ..In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages...
  47. ncbi Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:647-59. 2007
    ..Our data suggest that IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage...
  48. ncbi Discovery of a cytokine and its receptor by functional screening of the extracellular proteome
    Haishan Lin
    Five Prime Therapeutics, Inc, 1650 Owens Street, Suite 200, San Francisco, CA 94158, USA
    Science 320:807-11. 2008
    ..This systematic approach is thus useful for discovering new ligands and receptors and assessing the functional selectivity of extracellular regulatory proteins...
  49. ncbi IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase
    Georg F Weber
    Chirurgische Klinik und Poliklinik der Technischen Universität München, Ismaningerstrasse 22, 81675 Munich, Germany
    J Immunol 177:8266-72. 2006
    ..Therefore, IL-22 may play a role in the control of tumor growth and tumor progression...
  50. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  51. ncbi Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
    S C Pflugfelder
    Ocular Surface and Tear Center Bascom Palmer Eye Institute University of Miami School of Medicine Department of Ophthalmology Miami, FL 33136, USA
    Curr Eye Res 19:201-11. 1999
    ..To compare epidermal growth factor (EGF) concentration in tear fluid and levels of inflammatory cytokines in the conjunctival epithelium of patients with Sjögren's syndrome keratoconjunctivitis sicca with those of normal controls...
  52. ncbi IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
    Steven A Saenz
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 464:1362-6. 2010
    ....
  53. ncbi IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 207:273-80. 2010
    ..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...
  54. ncbi A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    Hans L Tillmann
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Gastroenterology 139:1586-92, 1592.e1. 2010
    ..We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population...
  55. ncbi Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
    Ling Yang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Hepatol 53:339-47. 2010
    ..However, it is currently unknown whether IL-22 has an effect on lipid metabolism in the liver...
  56. ncbi IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, D 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G960-8. 2005
    ....
  57. ncbi Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
    K Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Clin Exp Immunol 157:261-70. 2009
    ..In conclusion, IL-17-positive cells are associated with the chronic inflammation of bile ducts in PBC which is associated causally with the biliary innate immune responses to PAMPs...
  58. ncbi Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research NCHECR, University of New South Wales UNSW, Sydney, Australia
    Hepatology 52:1216-24. 2010
    ..Early therapeutic intervention could be recommended for individuals with unfavorable IL28B genotypes...
  59. ncbi Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
    Cell Host Microbe 5:476-86. 2009
    ..Thus, resistance to lipocalin-2 defines a specific adaptation of S. Typhimurium for growth in the inflamed intestine...
  60. ncbi Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Hepatol 53:439-43. 2010
    ..An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American, and European populations, has also been found to be associated with spontaneous eradication of the virus...
  61. ncbi Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 39:1332-42. 2004
    ....
  62. ncbi Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
    Suwen Wei
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Leukoc Biol 88:495-505. 2010
    ..Thus, the different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues...
  63. ncbi Cytokine expression in colon carcinoma
    Peter K Baier
    University of Freiburg, Department of Surgery, Freiburg, Germany
    Anticancer Res 25:2135-9. 2005
    ..Cytokines reflect the activity of the immune system. We analyzed the local expression of characteristic cytokines indicating the level of activity of unspecific inflammatory cells, Th1-cells and Th2-cells in colon cancer...
  64. ncbi The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models
    Erik Lubberts
    Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:29-37. 2005
    ..Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1 therapy...
  65. ncbi Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice
    J Alayan
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, QLD, Australia
    J Periodontal Res 42:97-103. 2007
    ..The purpose of this study was to observe the impact of targeted gene deletion of T helper 1 (Th1) and T helper 2 (Th2) cytokines on naturally occurring alveolar bone loss in genetically modified mice...
  66. ncbi Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 175:641-5. 2005
    ..Our studies suggest that IL-12 could act in concert with other proinflammatory factors to stimulate CD4(+)CD25(-) T cell activation in the presence of Treg...
  67. ncbi Cytokine expression in lupus kidneys
    M Aringer
    Department of Rheumatology, Medical University of Vienna, Vienna, Austria
    Lupus 14:13-8. 2005
    ..This may help solve discrepancies between different murine models of the disease and provide a better rationale for targeting certain cytokines in human SLE...
  68. ncbi Interchromosomal associations between alternatively expressed loci
    Charalampos G Spilianakis
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 435:637-45. 2005
    ..Thus, we provide an example of eukaryotic genes located on separate chromosomes associating physically in the nucleus via interactions that may have a function in coordinating gene expression...
  69. ncbi Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    ..Synergic TLR stimulation increased production of interleukins 12 and 23 and increased the Delta-4/Jagged-1 ratio, leading to DCs with enhanced and sustained T helper type 1-..
  70. ncbi Saliva of the Yellow Fever mosquito, Aedes aegypti, modulates murine lymphocyte function
    H A Wasserman
    Center for Tropical and Global Emerging Diseases and Department of Entomology, University of Georgia, Athens GA, USA
    Parasite Immunol 26:295-306. 2004
    ..These results suggest that A. aegypti saliva exerts a marked immunomodulatory influence on the environment at the bite site...
  71. ncbi Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    J Pineal Res 39:400-8. 2005
    ..In conclusion, we have demonstrated that melatonin improves the survival of mice with septic shock via its pleiotropic functions as an immunomodulator, antioxidant and anti-apoptotic mediator...
  72. ncbi Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
    J Li
    Laboratory of Immunopathology, The Institute of Digestive Diseases, Department of Medicine, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, China
    Scand J Immunol 64:515-22. 2006
    ..Thus, blockade of IL-21R signalling pathway may have a therapeutic potential in acute RA patients...
  73. ncbi Methylisothiazolinones elicit increased production of both T helper (Th)1- and Th2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals
    K Masjedi
    Department of Medicine, Unit of Clinical Allergy Research, Karolinska Institutet and Hospital, Stockholm, Sweden
    Br J Dermatol 149:1172-82. 2003
    ..This finding indicates that the organic compounds MCI/MI elicit a mixed Th1- and Th2-type of response, similar to that elicited by the metal ion Ni2+ in Ni2+-sensitized individuals...
  74. ncbi Intracellular cytokine profile of T lymphocytes in patients with chronic obstructive pulmonary disease
    B Barcelo
    Serveis d Anàlisi Clinics, Hospital Universitari Son Dureta, Institut Universitari d Investigacio en Ciencies de la Salut, IUNICS, Palma de Mallorca, Spain
    Clin Exp Immunol 145:474-9. 2006
    ..This is related inversely to the degree of airflow obstruction present...
  75. ncbi Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures
    A Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Clin Exp Allergy 36:777-84. 2006
    ....
  76. ncbi Type I cytokine profiles of human naïve and memory B lymphocytes: a potential for memory cells to impact polarization
    Alenka Gagro
    Institute of Immunology, Zagreb, Croatia
    Immunology 118:66-77. 2006
    ..Although poorly equipped for initiating type 1 responses, B cells--by virtue of the memory subset--reveal a capacity for their maintenance and amplification following T-dependent signalling...
  77. ncbi [Immunology of HCV infection: the causes of impaired cellular immune response and the effect of antiviral treatment]
    Gabriella Par
    Pécs Tudományegyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika
    Orv Hetil 147:591-600. 2006
    ....
  78. ncbi IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    Mari Strengell
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 79:1279-85. 2006
    ..Our results demonstrate that IL-21, a cytokine produced by activated T cells, can directly inhibit the activation and cytokine production of myeloid DCs, providing a negative feedback loop between DCs and T lymphocytes...
  79. ncbi The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses
    Amedeo Amedei
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Clin Invest 116:1092-101. 2006
    ..pylori-infected patients. These data indicate HP-NAP as an important factor of H. pylori able to elicit cells of the innate immune system to produce IL-12 and IL-23, and they suggest it as a new tool for promoting Th1 immune responses...
  80. ncbi Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells
    Marieke A Hoeve
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 36:661-70. 2006
    ....
  81. ncbi The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects
    Osamu Shimozato
    Division of Pathology, Chiba Cancer Center Research Institute, Nitona, Chiba, Japan
    Immunology 117:22-8. 2006
    ..p40 can thereby antagonize IL-23 and is a possible therapeutic agent for suppression of IL-23 functions...
  82. ncbi Murine serum cytokines throughout the estrous cycle, pregnancy and post partum period
    N M Orsi
    Perinatal Research Group, Academic Unit of Paediatrics, Obstetrics and Gynaecology, D Floor, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds LS2 9NS, UK
    Anim Reprod Sci 96:54-65. 2006
    ..The present findings suggest that the traditional cytokine dichotomy poorly describes complex immunological processes like pregnancy...
  83. ncbi Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors
    G P Garlet
    Department of Biochemistry and Immunology, School of Medicine USP, Ribeirao Preto, SP, Brazil
    Oral Microbiol Immunol 21:12-20. 2006
    ....
  84. ncbi Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines
    L E M Niers
    Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Allergy 35:1481-9. 2005
    ..These specific strains may be favorable to use in prevention or treatment of atopic disease...
  85. ncbi Molecular complementation of IL-12Rbeta1 deficiency reveals functional differences between IL-12Rbeta1 alleles including partial IL-12Rbeta1 deficiency
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, The Netherlands
    Hum Mol Genet 14:3847-55. 2005
    ..The QMG allele was found to be a higher IL-12 responder allele compared with the RTR allele. These results have implications for understanding IL-12R/IL-23R structure-function and the role of IL-12R/IL-23R in human disease...
  86. ncbi Influence of gravity changes induced by parabolic flight on cytokine production in mouse spleen
    Masakazu Kita
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Gravit Physiol 11:P67-8. 2004
    ..In this study, the alteration of cytokine responses in mice following parabolic flight (PF) was investigated...
  87. ncbi Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus
    Dipak R Patel
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Immunol 233:30-40. 2005
    ....
  88. ncbi Moderate zinc restriction affects intestinal health and immune function in lipopolysaccharide-challenged mice
    Daniel G Peterson
    Animal Science Department, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Nutr Biochem 19:193-9. 2008
    ..01). Results indicate that Zn status impacts intestinal responses to LPS through modulation of the cytokine response and leukocyte recruitment, and this impact is evident even with short-term (4 weeks) moderate Zn restriction...
  89. ncbi Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection
    Zheng Fan
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Vaccine Immunol 14:1127-37. 2007
    ..DCs from these infected subjects have a normal capacity to stimulate CD4+ T cells. The functional effectiveness of DCs derived from HCV-infected individuals provides a rationale for the DC-based immunotherapy of chronic HCV infection...
  90. ncbi Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:4886-90. 2003
    ..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system...
  91. ncbi Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis
    Tamara Krajina
    Department of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany
    Eur J Immunol 33:1073-83. 2003
    ..cLP DC may be interesting targets for novel therapeutic approaches to modulate mucosal T cell responses in situ...
  92. ncbi Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation
    Bo Chin Chiu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 29:106-16. 2003
    ..These findings reveal a complex cytokine-chemokine regulatory network that dictates profiles of local chemokine expression during T cell-mediated granuloma formation...
  93. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  94. ncbi CD40L induces proliferation, self-renewal, rescue from apoptosis, and production of cytokines by CD40-expressing AML blasts
    Donatella Aldinucci
    Clinical and Experimental Hematology Research Unit, I R C C S, Aviano, Italy
    Exp Hematol 30:1283-92. 2002
    ..In the present study, we analyzed the capability of CD40L/CD154 to modulate several functional aspects of CD40-expressing AML blasts...
  95. ncbi Expanded T cell clones and cytokines expression in human gastric carcinomas of different histological types
    Xiaoyin Zhang
    Institute of Digestive Diseases, 4th Military Medical University, Xi an 710032, China
    Zhonghua Bing Li Xue Za Zhi 31:120-3. 2002
    ..To study the characteristics of host immune response against human gastric carcinoma of different histological types...
  96. ncbi The modulatory effects of prostaglandin-E on cytokine production by human peripheral blood mononuclear cells are independent of the prostaglandin subtype
    Maaike M B W Dooper
    Department of Condition and Disease Specific Research, Numico Research B.V, Wageningen, The Netherlands
    Immunology 107:152-9. 2002
    ..This may implicate that the immunomodulatory effects of PUFAs, with respect to cytokine production, are not caused by a shift in the subtype of PGE...
  97. ncbi Decreased cytokine expression in peripheral blood leukocytes of patients with severe sepsis
    Neslihan Cabioglu
    Department of Surgery, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Arch Surg 137:1037-43; discussion 1043. 2002
    ..CONCLUSION: These results suggest that diminished lymphocyte- and monocyte-associated proinflammatory and anti-inflammatory cytokine levels are associated with worse prognosis in patients with severe sepsis...
  98. ncbi Melatonin induces changes to serum cytokines in mice infected with the Venezuelan equine encephalomyelitis virus
    Nereida Valero
    Instituto de Investigaciones Clinicas Dr Americo Negrette, Facultad de Medicina, Universidad del Zulia, Apartado 1151, Maracaibo 4001 A, Venezuela
    Trans R Soc Trop Med Hyg 96:348-51. 2002
    ....
  99. ncbi Temporal analysis of cytokine gene expression during infiltration of porcine neuronal grafts implanted into the rat brain
    Benoit Melchior
    Institut National de la Sante et de la Recherche Medicale, Unite 437, Centre Hospitalier Universitaire, Nantes, France
    J Neurosci Res 68:284-92. 2002
    ..These data support the concept that T lymphocyte infiltration of PNEU grafts is actively promoted by a local production of chemokines and proinflammatory lymphokines and is based on a Th1 polarization...
  100. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  101. ncbi Simultaneous analysis of eight human Th1/Th2 cytokines using microarrays
    Sun W Tam
    Genometrix, Inc, 2700 Research Forest Drive, The Woodlands, TX 77381, USA
    J Immunol Methods 261:157-65. 2002
    ..This platform provides a versatile system to rapidly quantify a wide variety of proteins in a multiplex format...

Research Grants90

  1. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  2. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..abstract_text> ..
  3. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  4. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ....
  5. Gene Polymorphism, Infection/Inflammation, Preterm Birth
    Xiaobin Wang; Fiscal Year: 2010
    ..VI. Maternal Questionnaire VII. Medical Record Abstraction Sheet PHS 398 (Rev. 4/98) (Form Page 3} Page 4 Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  6. Functional cloning of S. mansoni egg-specific Th2 cells
    Markus Mohrs; Fiscal Year: 2007
    ..mansoni egg-specific TCRs. The work outlined in this application will be a critical step towards the generation of tools urgently needed to study schistosomiasis, other helminthic diseases and fundamental principles of Th2 immunity. ..
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..We hypothesize that this signaling pathway regulates epithelial, proliferative repair responses after renal injury. If correct, then this would impact on most forms of acute and chronic renal damage. ..
  8. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
    ..1/8.2+ T cells and interferon-gamma, and interleukins-10 and 12 during the inductive phase of vaccination...
  9. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..1/8.2 ¿ T cells and interferon-y, and interleukins-10 and 12 during the inductive phase of vaccination...
  10. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  11. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ....
  12. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2010
    ..We now postulate that both systemic, particularly interleukins (interleukin)-1 and -6, and intrarenal (angiotensin II and p38 mitogen activated protein kinase) mediators ..
  13. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    PHILLIP HASHKES; Fiscal Year: 2007
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  14. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  15. Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
    Rebecca M Sappington; Fiscal Year: 2010
    ..We propose a series of studies to examine the potential of the inflammatory cytokine interleukin-6 as a therapeutic target to rescue RGCs in glaucoma. ..
  16. RETINAL CELL/LEUKOCYTE BINDING INDUCES CXC/CC CHEMOKINES
    Victor Elner; Fiscal Year: 2002
    ....
  17. Omega-3 polyunsaturated fatty acid supplementation and allergic diseases in child
    Isabelle Romieu; Fiscal Year: 2010
    ....
  18. Omega-3 polyunsaturated fatty acid supplementation and allergic diseases in child
    Isabelle Romieu; Fiscal Year: 2009
    ....
  19. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    John Allman; Fiscal Year: 2009
    ..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B and control groups. ..
  20. CYTOKINE NETWORKS REGULATE RPE LEUKOCYTE CHEMOTAXINS
    Victor Elner; Fiscal Year: 1993
    ....
  21. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2009
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  22. Modulation of the Immune System to Improve Ligament/Ligament Graft Healing
    RAY contact VANDERBY; Fiscal Year: 2010
    ..Developing these methods (via controlled delivery of inflammatory mediators from biomineral coatings on injectable microspheres) is the goal of this application. ..
  23. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
    ..abstract_text> ..
  24. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  25. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2005
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  26. Dissecting the Role of IL-12 in Naive CD8+ T cell Activation by Dendritic Cells
    CURTIS HENRY; Fiscal Year: 2007
    ..The findings generated through this work could be translated into the improvement of currently used vaccines and therapeutics against a variety of intracellular pathogens and tumors. ..
  27. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..Results will have practical application to IL1-associated brain pathologies including inflammation-associated sleep disturbances occurring in sleep apnea and metabolic syndrome. ..
  28. The Role of Interleukin-4 (IL-4) in the Pathogenesis of Non-Hodgkin's Lymphoma
    JAMES LOUIS RUBENSTEIN; Fiscal Year: 2010
    ....