interleukins

Summary

Summary: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.

Top Publications

  1. doi IL-17 and Th17 Cells
    Thomas Korn
    Technical University Munich, Department of Neurology, 81675 Munich, Germany
    Annu Rev Immunol 27:485-517. 2009
  2. doi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
  3. pmc Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    Spencer C Liang
    Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 203:2271-9. 2006
  4. pmc IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 448:484-7. 2007
  5. pmc Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    Daniel R Neill
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 464:1367-70. 2010
  6. doi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
  7. ncbi Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Yan Zheng
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 445:648-51. 2007
  8. pmc Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    Stefanie Eyerich
    Molecular Immunology, Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Clin Invest 119:3573-85. 2009
  9. doi Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
    Bruno Martin
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Immunity 31:321-30. 2009
  10. ncbi IL-22 increases the innate immunity of tissues
    Kerstin Wolk
    Corporate Research Business Area Dermatology, Schering AG, D 13342 Berlin, Germany
    Immunity 21:241-54. 2004

Detail Information

Publications274 found, 100 shown here

  1. doi IL-17 and Th17 Cells
    Thomas Korn
    Technical University Munich, Department of Neurology, 81675 Munich, Germany
    Annu Rev Immunol 27:485-517. 2009
    ..Furthermore, we now appreciate the importance of Th17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease...
  2. doi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
    ....
  3. pmc Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    Spencer C Liang
    Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 203:2271-9. 2006
    ..Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity...
  4. pmc IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 448:484-7. 2007
    ..We show that an IL-2 cytokine family member, IL-21, cooperates with TGF-beta to induce T(H)17 cells in naive Il6-/- T cells and that IL-21-receptor-deficient T cells are defective in generating a T(H)17 response...
  5. pmc Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    Daniel R Neill
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 464:1367-70. 2010
    ..Thus, nuocytes represent a critically important innate effector cell in type-2 immunity...
  6. doi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
    ..These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha...
  7. ncbi Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Yan Zheng
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 445:648-51. 2007
    ..IL-22, as an effector cytokine produced by T cells, mediates the crosstalk between the immune system and epithelial cells...
  8. pmc Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    Stefanie Eyerich
    Molecular Immunology, Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Clin Invest 119:3573-85. 2009
    ..Future strategies directed against the Th22 subset may be of value in chronic inflammatory skin disorders...
  9. doi Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
    Bruno Martin
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Immunity 31:321-30. 2009
    ....
  10. ncbi IL-22 increases the innate immunity of tissues
    Kerstin Wolk
    Corporate Research Business Area Dermatology, Schering AG, D 13342 Berlin, Germany
    Immunity 21:241-54. 2004
    ..Taken together, IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues...
  11. doi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  12. doi Regulation and functions of the IL-10 family of cytokines in inflammation and disease
    Wenjun Ouyang
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Annu Rev Immunol 29:71-109. 2011
    ..Finally, IL-10 itself can repress proinflammatory responses and limit unnecessary tissue disruptions caused by inflammation. Thus, IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases...
  13. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  14. pmc IL-35-mediated induction of a potent regulatory T cell population
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1093-101. 2010
    ..Thus, iT(R)35 cells constitute a key mediator of infectious tolerance and contribute to T(reg) cell-mediated tumor progression. Furthermore, iT(R)35 cells generated ex vivo might have therapeutic utility...
  15. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  16. doi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
    ..We sought to confirm the polymorphism's clinical relevance by intention-to-treat analysis evaluating on-treatment virologic response and SVR...
  17. pmc IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
    Steven A Saenz
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 464:1362-6. 2010
    ....
  18. pmc IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    David Yen
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1310-6. 2006
    ..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
  19. doi Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    Gregory F Sonnenberg
    Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:383-90. 2011
    ....
  20. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..Using passive transfer studies, we confirm that these IL-23-dependent CD4(+) T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity...
  21. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  22. ncbi IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Eur J Immunol 36:1309-23. 2006
    ..In summary, despite similarities, IFN-gamma primarily amplifies inflammation, while IL-22 may be important in the innate immunity and reorganization of epithelia...
  23. ncbi IL-23 promotes tumour incidence and growth
    John L Langowski
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
    Nature 442:461-5. 2006
    ..We show that IL-23 is an important molecular link between tumour-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumours...
  24. pmc IL-33 exacerbates antigen-induced arthritis by activating mast cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 105:10913-8. 2008
    ..Thus, this IL-1 superfamily member represents a therapeutic target for RA...
  25. doi Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    Sara Trifari
    Department of Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 10:864-71. 2009
    ..AHR agonists substantially altered the balance of IL-22- versus IL-17-producing cells. This subset of IL-22-producing cells may be important in skin homeostasis and pathology...
  26. pmc Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
    ..To our knowledge, this is the strongest and most significant genetic effect associated with natural clearance of HCV, and these results implicate a primary role for IL28B in resolution of HCV infection...
  27. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  28. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
    ..In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing...
  29. pmc Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:647-59. 2007
    ..Our data suggest that IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage...
  30. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses...
  31. ncbi Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Daniel J Cua
    Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
    Nature 421:744-8. 2003
    ..In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages...
  32. pmc The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?
    Christine Moussion
    CNRS, Institute of Pharmacology and Structural Biology, Toulouse, France
    PLoS ONE 3:e3331. 2008
    ..Although the activity of recombinant IL-33 has been well characterized, little is known yet about the expression pattern of endogenous IL-33 in vivo...
  33. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
    ..Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection...
  34. pmc Interleukin 33 as a mechanically responsive cytokine secreted by living cells
    Rahul Kakkar
    Department of Medicine, Harvard Stem Cell Institute and the Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 287:6941-8. 2012
    ..These data document IL-33 dynamic inter-organelle trafficking and release during biomechanical overload. As such we recharacterize IL-33 as both an inflammatory as well as mechanically responsive cytokine secreted by living cells...
  35. pmc IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    Li Yang
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 454:350-2. 2008
    ..These data will allow the investigation of this new population of T(H)17 cells in human inflammatory disease...
  36. ncbi TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    Ahjoku Amadi-Obi
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 13:711-8. 2007
    ....
  37. pmc Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    Laurel A Monticelli
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:1045-54. 2011
    ..Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus...
  38. doi Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 139:499-509. 2010
    ..Multiple viral and host factors are related to the treatment response to pegylated-interferon and ribavirin combination therapy; however, the clinical relevance and relationship of these factors have not yet been fully evaluated...
  39. pmc Circulating Th17, Th22, and Th1 cells are increased in psoriasis
    Shinji Kagami
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA
    J Invest Dermatol 130:1373-83. 2010
    ..In summary, elevated numbers of circulating inflammatory T cells may contribute to cutaneous inflammation and systemic inflammatory disease that occurs in individuals with psoriasis...
  40. doi Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA
    J Invest Dermatol 128:1207-11. 2008
    ..Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets...
  41. doi Disease-associated functions of IL-33: the new kid in the IL-1 family
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 10:103-10. 2010
    ..Thus IL-33 could be a new target for therapeutic intervention across a range of diseases...
  42. pmc IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    Dimitra Zotos
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    J Exp Med 207:365-78. 2010
    ..The absence of IL-21 or IL-21 receptor does not abrogate the appearance of T cells in GCs or the appearance of CD4 T cells with a follicular helper phenotype. IL-21 thus controls fate choices of GC B cells directly...
  43. doi Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Genet 41:1105-9. 2009
    ..52 x 10(-28)-2.68 x 10(-32); OR = 22.3-27.1). Real-time quantitative PCR assays in peripheral blood mononuclear cells showed lower IL28B expression levels in individuals carrying the minor alleles (P = 0.015)...
  44. ncbi Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    M A Cooper
    Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH, USA
    Blood 97:3146-51. 2001
    ..It is proposed that human CD56(bright) NK cells have a unique functional role in the innate immune response as the primary source of NK cell-derived immunoregulatory cytokines, regulated in part by differential monokine production...
  45. pmc IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
    Emma Lefrançais
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, F 31077 Toulouse, France
    Proc Natl Acad Sci U S A 109:1673-8. 2012
    ..We propose that the inflammatory microenvironment may exacerbate disease-associated functions of IL-33 through the generation of highly active mature forms...
  46. doi Mast cells as sensors of cell injury through IL-33 recognition
    Mattias Enoksson
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Immunol 186:2523-8. 2011
    ..Our findings identify IL-33 as a key danger signal released by necrotic structural cells capable of activating mast cells, thus providing novel insights concerning the role of mast cells as sensors of cell injury...
  47. doi Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
    Runqiu Jiang
    Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China
    Hepatology 54:900-9. 2011
    ..An in vivo diethyl-nitrosamine-induced mouse HCC model verified that tumor formation was significantly decreased in IL-22 knockout mice...
  48. doi Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    Jenny M Mjösberg
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 12:1055-62. 2011
    ..There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines...
  49. pmc IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs
    Kathleen R Bartemes
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 188:1503-13. 2012
    ..These cells may provide a novel mechanism for type 2 immunity in the airways and induction of allergic airway diseases such as asthma...
  50. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  51. ncbi Role of deficient type III interferon-lambda production in asthma exacerbations
    Marco Contoli
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 12:1023-6. 2006
    ..These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations...
  52. pmc The cytokine interleukin-33 mediates anaphylactic shock
    Peter N Pushparaj
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:9773-8. 2009
    ..This report therefore reveals a hitherto unrecognized pathophysiological role of IL-33 and suggests that IL-33 may be a potential therapeutic target for anaphylaxis, a disease of considerable unmet medical need...
  53. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009
    ..Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control...
  54. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
    ..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...
  55. pmc IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
    Virginie Carriere
    Laboratoire de Biologie Vasculaire, Equipe Labellisée La Ligue 2006, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse, France
    Proc Natl Acad Sci U S A 104:282-7. 2007
    ..Together, these data suggest that, similarly to IL1alpha and HMGB1, IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties...
  56. doi Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    S Brand
    Department of Medicine II Grosshadern, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    Gut 58:1152-67. 2009
    ..However, the complex relationship between Th1 and Th17 cells has not been completely analysed. This will be of great importance to delineate the specific contributions of these cells to Crohn's disease and other autoimmune diseases...
  57. pmc IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    Ken Sugimoto
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 118:534-44. 2008
    ..These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene-delivery system for treating UC...
  58. pmc A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:164-71. 2013
    ..Our findings provide new insights into the genetic regulation of HCV clearance and its clinical management...
  59. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  60. ncbi Interleukin-12 and the regulation of innate resistance and adaptive immunity
    Giorgio Trinchieri
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
    Nat Rev Immunol 3:133-46. 2003
    ....
  61. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  62. pmc RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    Stephanie L Sanos
    Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Nat Immunol 10:83-91. 2009
    ..IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis...
  63. pmc Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response
    Jama M Darling
    University of North Carolina, Chapel Hill, NC 27599, USA
    Hepatology 53:14-22. 2011
    ..IL28B genotype and baseline IP-10 levels were additive but independent when predicting SVR in both AA and CA patients...
  64. doi Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    Caroline E Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 31:331-41. 2009
    ..Our findings demonstrate that gammadelta T cells activated by IL-1beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation...
  65. doi RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    Shinichiro Sawa
    Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France
    Nat Immunol 12:320-6. 2011
    ..Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and RORγt+ ILCs...
  66. pmc Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    Rimpei Morita
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 34:108-21. 2011
    ..Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity...
  67. doi An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    Alessandra Mangia
    Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Gastroenterology 139:821-7, 827.e1. 2010
    ..We evaluated the effects of IL-28B polymorphisms on response to treatment with peginterferon and ribavirin in a well-characterized cohort of genotype 2/3 patients...
  68. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
    ..Thus, it appears that splenic LTi-like cells are a rapid source of IL-17 and IL-22, which might contribute to dynamic organization of secondary lymphoid organ structure or host defense...
  69. pmc Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    Heather R Conti
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
    J Exp Med 206:299-311. 2009
    ..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
  70. pmc The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    Ju Qiu
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Immunity 36:92-104. 2012
    ..Our data uncover a previously unrecognized physiological role for Ahr in promoting innate gut immunity by regulating RORγt(+) ILCs...
  71. doi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  72. pmc IL-33 is a crucial amplifier of innate rather than acquired immunity
    Keisuke Oboki
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Proc Natl Acad Sci U S A 107:18581-6. 2010
    ..These observations indicate that IL-33 is a crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses...
  73. pmc Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    Gregory F Sonnenberg
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 336:1321-5. 2012
    ..Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases...
  74. ncbi Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    Tobias Marcello
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    Gastroenterology 131:1887-98. 2006
    ..We aimed to determine whether IFN-lambda exhibits antiviral activity toward HCV and to compare the signal transduction and effector gene pathways with those of IFN-alpha...
  75. doi The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 453:106-9. 2008
    ..AHR ligands may therefore represent co-factors in the development of autoimmune diseases...
  76. pmc IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    Thomas J Urban
    Center for Human Genome Variation, Duke University Medical Center, Durham, NC, USA
    Hepatology 52:1888-96. 2010
    ..IL28B protein sequence variants associated with rs12979860 were therefore investigated in vitro: no differences in ISG induction or inhibition of HCV replication were observed in Huh7.5 cells...
  77. pmc Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 USA
    Immunity 29:947-57. 2008
    ..In addition, IL-22 expression was differentially regulated between NK cell subsets. Thus, both the innate and adaptive immune responses have developed protective mechanisms to counteract the damaging effects of inflammation on tissues...
  78. ncbi IL-28, IL-29 and their class II cytokine receptor IL-28R
    Paul Sheppard
    ZymoGenetics, Inc, 1201 Eastlake Avenue E, Seattle, WA 98102, USA
    Nat Immunol 4:63-8. 2003
    ..This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection...
  79. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
  80. pmc AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    Jacob S Lee
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:144-51. 2012
    ..Thus, AHR was essential for ILC22 cells and postnatal intestinal lymphoid tissues. Moreover, ILC22 subsets were heterogeneous in their requirement for Notch and their effect on the generation of intestinal lymphoid tissues...
  81. doi Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:701-21.e1-70. 2011
    ..We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections...
  82. pmc The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    Corinne Cayrol
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, F 31077 Toulouse, France
    Proc Natl Acad Sci U S A 106:9021-6. 2009
    ..We speculate that IL-33 may function, similarly to the prototypical alarmins HMGB1 and IL-1alpha, as an endogenous danger signal to alert cells of the innate immune system of tissue damage during trauma or infection...
  83. pmc The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    Lionel Apetoh
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:854-61. 2010
    ..Manipulating AhR signaling could therefore be beneficial in the resolution of excessive inflammatory responses...
  84. pmc Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity
    Ozer Arican
    Department of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Turkey
    Mediators Inflamm 2005:273-9. 2005
    ..Furthermore, high levels of IFN-gamma, IL-12, and IL-18 correlated with the clinical severity and activity of psoriasis, and those measurements of serum levels of these cytokines may be objective parameters for the disease severity...
  85. pmc Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    Gregory F Sonnenberg
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 207:1293-305. 2010
    ....
  86. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
    ....
  87. pmc Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
    Koubun Yasuda
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 109:3451-6. 2012
    ..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
  88. ncbi IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    Wanda Niedbala
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:3021-9. 2007
    ..Thus, IL-35 is a novel anti-inflammatory cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development...
  89. doi Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypes
    Marco Antonio Montes-Cano
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio Instituto de Biomedicina de Sevilla, Sevilla, Spain
    Hepatology 52:33-7. 2010
    ..2 x 10(-5), OR = 0.32; 95%CI, 0.18-0.57); and lastly, patients with sustained response (60.2% versus 32.1% found in patients with nonsustained response, P = 3.1 x 10(-5), OR = 0.31; 95%CI, 0.17-0.56)...
  90. pmc IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    Shean J Aujla
    Children s Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:275-81. 2008
    ..These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites...
  91. ncbi IL-33, a potent inducer of adaptive immunity to intestinal nematodes
    Neil E Humphreys
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
    J Immunol 180:2443-9. 2008
    ..Thus, the ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection, particularly during the initiation of the response...
  92. pmc Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:253-65. 2010
    ..Our results reveal insight into the dynamic regulation of T cell:B cell interactions and identify SLAM family members as critical components of sustained T cell:B cell adhesion required for productive humoral immunity...
  93. ncbi Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
    Franck J D Mennechet
    Centre National de la Recherche Scientifique Unité mixte de recherche 5124, University of Montpellier, Place Eugene Bataillon 34095, Montpellier Cedex 5, France
    Blood 107:4417-23. 2006
    ..IFN-lambdas are thus able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions...
  94. pmc Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    Jeanette J McCarthy
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27708, USA
    Gastroenterology 138:2307-14. 2010
    ..We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients...
  95. doi Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Gastroenterology 140:1021-31. 2011
    ..We investigated whether IL28B genotype determines the constitutive expression of ISGs in the liver and compared the abilities of ISG levels and IL28B genotype to predict treatment outcome...
  96. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  97. pmc The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    Aurelie T Bauquet
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 10:167-75. 2009
    ..Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells...
  98. doi Biology of interleukin-22
    Kerstin Wolk
    University Hospital Charite, Berlin, Germany
    Semin Immunopathol 32:17-31. 2010
    ....
  99. pmc Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes
    Cedric Vonarbourg
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Immunity 33:736-51. 2010
    ..Our data also define a previously unappreciated role of RORγt⁻ NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...
  100. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
    ..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
  101. pmc Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation
    Mark A Kroenke
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 188:3734-44. 2012
    ..Altogether, these findings reveal that Bcl6 and Maf collaborate to orchestrate a suite of genes that define core characteristics of human Tfh cell biology...

Research Grants76

  1. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a simple mechanistically-based treatment for this chronic extraordinarily common dental disorder. ..
  4. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ....
  5. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
    ....
  6. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ....
  7. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..The proposed studies will address important pathophysiological questions regarding the mechanisms regulating appetite and satiety as well as provide potentially important clinical treatment strategies. ..
  8. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  9. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  10. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..These results will identify new approaches and targets for preventing sporadic colorectal cancer. ..
  11. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  12. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
  13. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..If successful, this grant could help explain the causes of iron deficiency anemia and could help in designing better drugs to combat iron deficiency anemia. ..
  14. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
  15. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..abstract_text> ..
  16. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..g. asthma) and cancer. This proposal will use a mouse model of inflammation to test our hypothesis that interleukins 4 and 13 are essential for the differentiation of a specific functional population of MF (alternatively ..
  17. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..The results of the studies will advance our knowledge on how vitamin D can be used as a therapeutic agent to improve inflammation in humans. ..
  18. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Shorter telomeres have been linked to cancer risk. The project includes 438 postmenopausal, overweight/obese, sedentary women who have already completed the trial from which blood samples will be used. ..
  19. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..This is an exciting area of research that could benefit the veterans that make a large portion of the general smoking population. ..
  20. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..Determining the role of IL-10 in mediating fatal viral encephalomyelitis pathology will increase our understanding of the mechanisms responsible for severe and fatal infections and provide a basis for therapeutic development. ..
  21. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..low levels of high-density lipoprotein cholesterol (HDL-C), elevated inflammation (C-reactive protein (CRP) and interleukins (IL-1A)), deranged glucose homeostasis, hypertension and endothelia dysfunction are precursors of ..
  22. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  23. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..The Stanford ACE proposes clinical research projects that encompass three different autoimmune diseases (SSc, psoriatic arthritis and SJIA), and proposes to study the MoA of therapeutics for preventing or treating different Al diseases. ..
  24. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
    ..These studies may provide the basis for novel therapeutic approaches to inflammatory bowel disease and CAC. ..
  25. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Interleukin-17 can cause lung inflammation and asthma. This project is to indentify drugs that can inhibit IL-17 and lung inflammation. ..
  26. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ....
  27. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ....
  28. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ....
  29. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..Findings of the proposed studies are expected to shed light on the conceptualization of treatment and prevention strategies that aim at fundamentally correcting the underlying neural circuit deficits. ..
  30. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ....
  31. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..We now postulate that both systemic, particularly interleukins (interleukin)-1 and -6, and intrarenal (angiotensin II and p38 mitogen activated protein kinase) mediators ..
  32. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ....
  33. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..abstract_text> ..
  34. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..
  35. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ....
  36. Pathogenesis of Postoperative Cognitive Dysfunction
    Zhongcong Xie; Fiscal Year: 2013
    ..This proposal aims to investigate an understudied topic in an innovative system by testing novel hypotheses. Our efforts would ultimately lead to safer surgical care and better post-operative outcomes for senior patients. ..
  37. Stat3 Downstream Genes as Lung Adenocarcinoma Biomarkers
    Cong Yan; Fiscal Year: 2013
    ..This work will identify protein biomarkers for lung cancer diagnosis and prognosis in humans and in animals. ..
  38. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ....
  39. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ....
  40. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ....
  41. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  42. Gene Transcription in SLE
    George C Tsokos; Fiscal Year: 2012
    ..The proposed studies will explore the mechanisms that lead to decreased production of interleukin-2 in order to identify molecules that we can target for therapeutic purposes. ..
  43. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    ....
  44. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..The BMT/CTN including our consortium will be the only clinical cooperative group to accomplish this goal. ..
  45. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..In this proposal, we aim to undertake its biological characterization, by exploring its effects on leukocytes in vitro as well as its function in vivo. ..
  46. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
  47. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
  48. Double Humanization of Liver and Blood in Mice
    ELIZABETH MARIE WILSON; Fiscal Year: 2012
    ....
  49. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ....
  50. The Role of PKR in a Novel IL-3 Signal Transduction Pathway
    William Stratford May; Fiscal Year: 2012
    ..Results will point the way to and provide a basis for discovering novel anti-leukemia therapies. ..
  51. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..This research will determine if exposure to these compounds is a risk factor for development of T2D and if so will provide mechanisms through which these compounds precipitate this disease. ..
  52. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..coli, the genetically susceptible individual's ability to process these organisms, and subsequent metabolic pathways involved in disease pathogenesis. ..
  53. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ....
  54. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..e. tumor necrosis factor-a inhibitors. ..
  55. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
  56. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ..binding globulin (SHBG) and catechol-O-methyltransferase (COMT), and in immune/inflammatory pathways include interleukins (IL), nuclear factor kappa B (NF-:B), tumor necrosis factor alpha (TNF-1) and lymphotoxin alpha (LTA)...
  57. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..The results are likely to be beneficial for not only patients with scleroderma, but also patients with asthma, sepsis, and tuberculosis, in all of which IL-442 has been suggested to play a significant role. ..
  58. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011
    ..The goals are to clarify potential causative mechanisms and discern how these are altered by therapeutic interventions with the aim of developing better therapeutic interventions for mood disorders. ..
  59. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    ....
  60. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..This will decrease the number of islets required to achieve normoglycemia in type I diabetic patients. ..
  61. Brain interleukin-18 control of food intake and energy expenditure
    Eric P Zorrilla; Fiscal Year: 2013
    ..Such information will be key for beginning to understand the pathophysiologic and potential therapeutic relevance of central IL-18 signaling for disorders of energy homeostasis, such as obesity or cachexia. ..
  62. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ....
  63. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..An understanding of these processes is necessary for the development of ethnically and culturally relevant prevention efforts. ..
  64. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1991
    ....
  65. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..Our preliminary results indicate that Interleukin 10 may be very important to protect the brain blood vessels from damage during this infection. We propose to study this in a mouse model of spirochetal brain infection. ..
  66. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..1/8.2 [unreadable] T cells and interferon-y, and interleukins-10 and 12 during the inductive phase of vaccination...
  67. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  68. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ....
  69. ESTROGEN REGULATION OF HUMAN INTERLEUKIN 6 GENE PROMOTER
    Sreenivas Koka; Fiscal Year: 1999
    ..Identification of the mechanisms by which estrogen regulates IL-6 gene expression will enhance our understanding of the pathobiology of osteoporosis and suggest future strategies aimed at treating and preventing this disease. ..
  70. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  71. EFFECTS OF PHORBOL ESTERS ON LYMPHOCYTE STIMULATION
    Andrea Mastro; Fiscal Year: 1991
    ..The cells will also be tested for suppressor activity...
  72. Development of therapeutic monoclonal antibody to the bioactive lipid lysophospha
    Rosalia Matteo; Fiscal Year: 2009
    ..Discovering the major determinants in cancer progression for the development of more efficacious therapies is therefore extremely important to society. ..
  73. 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Stavros Manolagas; Fiscal Year: 1991
    ....
  74. INTERLEUKIN REGULATION OF PROOPIOMELANOCORTIN GENE
    S Brown; Fiscal Year: 1990
    ..Finally, we will determine if like CRF, monokines and lymphokines stimulate cAMP generation in pituitary cells. These studies will determine if molecules of divergent origin produce common effects through similar mechanisms...
  75. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  76. INTERLEUKIN 5 GENE EXPRESSION AND LUNG INFLAMMATION
    Anuradha Ray; Fiscal Year: 2000
    ..The expression of this gene will be determined in antigen and virus models of airway inflammation in the presence or absence of glucocorticoids. ..