interleukins

Summary

Summary: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.

Top Publications

  1. doi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
  2. doi IL-17 and Th17 Cells
    Thomas Korn
    Technical University Munich, Department of Neurology, 81675 Munich, Germany
    Annu Rev Immunol 27:485-517. 2009
  3. pmc Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
  4. doi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
  5. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
  6. doi Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Genet 41:1105-9. 2009
  7. pmc Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    Daniel R Neill
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 464:1367-70. 2010
  8. pmc Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    Spencer C Liang
    Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 203:2271-9. 2006
  9. doi Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    Gregory F Sonnenberg
    Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:383-90. 2011
  10. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009

Research Grants

  1. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
  3. Biomedical Simulations Resource (BMSR)
    DAVID D ARGENIO; Fiscal Year: 2009
  4. Biomedical Simulations Resource (BMSR)
    DAVID Z D apos ARGENIO; Fiscal Year: 2010
  5. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
  6. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2009
  7. DCTD Biopharmaceutical Development - Type 1 Diabetes RAID projects
    LARRY ARTHUR; Fiscal Year: 2009
  8. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2012
  9. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2011
  10. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2010

Detail Information

Publications234 found, 100 shown here

  1. doi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
    ....
  2. doi IL-17 and Th17 Cells
    Thomas Korn
    Technical University Munich, Department of Neurology, 81675 Munich, Germany
    Annu Rev Immunol 27:485-517. 2009
    ..Furthermore, we now appreciate the importance of Th17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease...
  3. pmc Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
    ..To our knowledge, this is the strongest and most significant genetic effect associated with natural clearance of HCV, and these results implicate a primary role for IL28B in resolution of HCV infection...
  4. doi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
    ..These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha...
  5. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  6. doi Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Genet 41:1105-9. 2009
    ..52 x 10(-28)-2.68 x 10(-32); OR = 22.3-27.1). Real-time quantitative PCR assays in peripheral blood mononuclear cells showed lower IL28B expression levels in individuals carrying the minor alleles (P = 0.015)...
  7. pmc Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    Daniel R Neill
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 464:1367-70. 2010
    ..Thus, nuocytes represent a critically important innate effector cell in type-2 immunity...
  8. pmc Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    Spencer C Liang
    Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 203:2271-9. 2006
    ..Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity...
  9. doi Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    Gregory F Sonnenberg
    Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:383-90. 2011
    ....
  10. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
    ....
  11. ncbi IL-22 increases the innate immunity of tissues
    Kerstin Wolk
    Corporate Research Business Area Dermatology, Schering AG, D 13342 Berlin, Germany
    Immunity 21:241-54. 2004
    ..Taken together, IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues...
  12. doi Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    Yan Zheng
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 14:282-9. 2008
    ..rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens...
  13. pmc Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    Stefanie Eyerich
    Molecular Immunology, Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Clin Invest 119:3573-85. 2009
    ..Future strategies directed against the Th22 subset may be of value in chronic inflammatory skin disorders...
  14. ncbi Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Gastroenterology 138:1338-45, 1345.e1-7. 2010
    ..We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy...
  15. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  16. doi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  17. pmc IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
    Steven A Saenz
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 464:1362-6. 2010
    ....
  18. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  19. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses...
  20. doi Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    Sara Trifari
    Department of Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 10:864-71. 2009
    ..AHR agonists substantially altered the balance of IL-22- versus IL-17-producing cells. This subset of IL-22-producing cells may be important in skin homeostasis and pathology...
  21. doi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
    ..We sought to confirm the polymorphism's clinical relevance by intention-to-treat analysis evaluating on-treatment virologic response and SVR...
  22. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  23. pmc IL-35-mediated induction of a potent regulatory T cell population
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1093-101. 2010
    ..Thus, iT(R)35 cells constitute a key mediator of infectious tolerance and contribute to T(reg) cell-mediated tumor progression. Furthermore, iT(R)35 cells generated ex vivo might have therapeutic utility...
  24. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  25. ncbi IL-28, IL-29 and their class II cytokine receptor IL-28R
    Paul Sheppard
    ZymoGenetics, Inc, 1201 Eastlake Avenue E, Seattle, WA 98102, USA
    Nat Immunol 4:63-8. 2003
    ..This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection...
  26. doi Regulation and functions of the IL-10 family of cytokines in inflammation and disease
    Wenjun Ouyang
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Annu Rev Immunol 29:71-109. 2011
    ..Finally, IL-10 itself can repress proinflammatory responses and limit unnecessary tissue disruptions caused by inflammation. Thus, IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases...
  27. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..Using passive transfer studies, we confirm that these IL-23-dependent CD4(+) T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity...
  28. pmc IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    Shean J Aujla
    Children s Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:275-81. 2008
    ..These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites...
  29. ncbi The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 453:106-9. 2008
    ..AHR ligands may therefore represent co-factors in the development of autoimmune diseases...
  30. pmc IL-33 exacerbates antigen-induced arthritis by activating mast cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 105:10913-8. 2008
    ..Thus, this IL-1 superfamily member represents a therapeutic target for RA...
  31. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
    ..Thus, it appears that splenic LTi-like cells are a rapid source of IL-17 and IL-22, which might contribute to dynamic organization of secondary lymphoid organ structure or host defense...
  32. pmc IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    Li Yang
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 454:350-2. 2008
    ..These data will allow the investigation of this new population of T(H)17 cells in human inflammatory disease...
  33. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
    ..In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing...
  34. pmc Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:647-59. 2007
    ..Our data suggest that IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage...
  35. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
    ..Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection...
  36. doi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  37. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  38. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  39. pmc Interleukin 33 as a mechanically responsive cytokine secreted by living cells
    Rahul Kakkar
    Department of Medicine, Harvard Stem Cell Institute and the Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 287:6941-8. 2012
    ..These data document IL-33 dynamic inter-organelle trafficking and release during biomechanical overload. As such we recharacterize IL-33 as both an inflammatory as well as mechanically responsive cytokine secreted by living cells...
  40. doi Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:701-21.e1-70. 2011
    ..We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections...
  41. ncbi Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 139:499-509. 2010
    ..Multiple viral and host factors are related to the treatment response to pegylated-interferon and ribavirin combination therapy; however, the clinical relevance and relationship of these factors have not yet been fully evaluated...
  42. ncbi IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Eur J Immunol 36:1309-23. 2006
    ..In summary, despite similarities, IFN-gamma primarily amplifies inflammation, while IL-22 may be important in the innate immunity and reorganization of epithelia...
  43. pmc Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 USA
    Immunity 29:947-57. 2008
    ..In addition, IL-22 expression was differentially regulated between NK cell subsets. Thus, both the innate and adaptive immune responses have developed protective mechanisms to counteract the damaging effects of inflammation on tissues...
  44. ncbi Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Daniel J Cua
    Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
    Nature 421:744-8. 2003
    ..In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages...
  45. ncbi Disease-associated functions of IL-33: the new kid in the IL-1 family
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 10:103-10. 2010
    ..Thus IL-33 could be a new target for therapeutic intervention across a range of diseases...
  46. pmc IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    Dimitra Zotos
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    J Exp Med 207:365-78. 2010
    ..The absence of IL-21 or IL-21 receptor does not abrogate the appearance of T cells in GCs or the appearance of CD4 T cells with a follicular helper phenotype. IL-21 thus controls fate choices of GC B cells directly...
  47. doi Mast cells as sensors of cell injury through IL-33 recognition
    Mattias Enoksson
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Immunol 186:2523-8. 2011
    ..Our findings identify IL-33 as a key danger signal released by necrotic structural cells capable of activating mast cells, thus providing novel insights concerning the role of mast cells as sensors of cell injury...
  48. ncbi Interleukin-12 and the regulation of innate resistance and adaptive immunity
    Giorgio Trinchieri
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
    Nat Rev Immunol 3:133-46. 2003
    ....
  49. ncbi Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
    Runqiu Jiang
    Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China
    Hepatology 54:900-9. 2011
    ..An in vivo diethyl-nitrosamine-induced mouse HCC model verified that tumor formation was significantly decreased in IL-22 knockout mice...
  50. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
    ..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...
  51. pmc IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
    Virginie Carriere
    Laboratoire de Biologie Vasculaire, Equipe Labellisée La Ligue 2006, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse, France
    Proc Natl Acad Sci U S A 104:282-7. 2007
    ..Together, these data suggest that, similarly to IL1alpha and HMGB1, IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties...
  52. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  53. pmc Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
    Ya Jen Chang
    Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:631-8. 2011
    ..Infection with influenza A virus, which activates the NLRP3 inflammasome, resulted in much more production of IL-33 by alveolar macrophages, which in turn activated natural helper cells producing substantial IL-13...
  54. pmc IL-33 is a crucial amplifier of innate rather than acquired immunity
    Keisuke Oboki
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Proc Natl Acad Sci U S A 107:18581-6. 2010
    ..These observations indicate that IL-33 is a crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses...
  55. ncbi Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    M A Cooper
    Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH, USA
    Blood 97:3146-51. 2001
    ..It is proposed that human CD56(bright) NK cells have a unique functional role in the innate immune response as the primary source of NK cell-derived immunoregulatory cytokines, regulated in part by differential monokine production...
  56. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009
    ..Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control...
  57. pmc The cytokine interleukin-33 mediates anaphylactic shock
    Peter N Pushparaj
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:9773-8. 2009
    ..This report therefore reveals a hitherto unrecognized pathophysiological role of IL-33 and suggests that IL-33 may be a potential therapeutic target for anaphylaxis, a disease of considerable unmet medical need...
  58. ncbi Role of deficient type III interferon-lambda production in asthma exacerbations
    Marco Contoli
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 12:1023-6. 2006
    ..These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations...
  59. pmc IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    Ken Sugimoto
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 118:534-44. 2008
    ..These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene-delivery system for treating UC...
  60. pmc The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    Corinne Cayrol
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, F 31077 Toulouse, France
    Proc Natl Acad Sci U S A 106:9021-6. 2009
    ..We speculate that IL-33 may function, similarly to the prototypical alarmins HMGB1 and IL-1alpha, as an endogenous danger signal to alert cells of the innate immune system of tissue damage during trauma or infection...
  61. ncbi Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Yan Zheng
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 445:648-51. 2007
    ..IL-22, as an effector cytokine produced by T cells, mediates the crosstalk between the immune system and epithelial cells...
  62. pmc Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response
    Jama M Darling
    University of North Carolina, Chapel Hill, NC 27599, USA
    Hepatology 53:14-22. 2011
    ..IL28B genotype and baseline IP-10 levels were additive but independent when predicting SVR in both AA and CA patients...
  63. doi RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    Stephanie L Sanos
    Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Nat Immunol 10:83-91. 2009
    ..IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis...
  64. pmc IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    Thomas J Urban
    Center for Human Genome Variation, Duke University Medical Center, Durham, NC, USA
    Hepatology 52:1888-96. 2010
    ..IL28B protein sequence variants associated with rs12979860 were therefore investigated in vitro: no differences in ISG induction or inhibition of HCV replication were observed in Huh7.5 cells...
  65. doi An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    Alessandra Mangia
    Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Gastroenterology 139:821-7, 827.e1. 2010
    ..We evaluated the effects of IL-28B polymorphisms on response to treatment with peginterferon and ribavirin in a well-characterized cohort of genotype 2/3 patients...
  66. pmc Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    Heather R Conti
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
    J Exp Med 206:299-311. 2009
    ..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
  67. ncbi TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    Ahjoku Amadi-Obi
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 13:711-8. 2007
    ....
  68. ncbi Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    Tobias Marcello
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    Gastroenterology 131:1887-98. 2006
    ..We aimed to determine whether IFN-lambda exhibits antiviral activity toward HCV and to compare the signal transduction and effector gene pathways with those of IFN-alpha...
  69. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
  70. ncbi Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    Caroline E Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 31:331-41. 2009
    ..Our findings demonstrate that gammadelta T cells activated by IL-1beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation...
  71. doi Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypes
    Marco Antonio Montes-Cano
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio Instituto de Biomedicina de Sevilla, Sevilla, Spain
    Hepatology 52:33-7. 2010
    ..2 x 10(-5), OR = 0.32; 95%CI, 0.18-0.57); and lastly, patients with sustained response (60.2% versus 32.1% found in patients with nonsustained response, P = 3.1 x 10(-5), OR = 0.31; 95%CI, 0.17-0.56)...
  72. ncbi IL-23 promotes tumour incidence and growth
    John L Langowski
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
    Nature 442:461-5. 2006
    ..We show that IL-23 is an important molecular link between tumour-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumours...
  73. pmc Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    Jeanette J McCarthy
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27708, USA
    Gastroenterology 138:2307-14. 2010
    ..We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients...
  74. ncbi Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
    Franck J D Mennechet
    Centre National de la Recherche Scientifique Unité mixte de recherche 5124, University of Montpellier, Place Eugene Bataillon 34095, Montpellier Cedex 5, France
    Blood 107:4417-23. 2006
    ..IFN-lambdas are thus able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions...
  75. doi Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
    Alexander U Lüthi
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    Immunity 31:84-98. 2009
    ..Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33...
  76. doi Interleukin-33 - cytokine of dual function or novel alarmin?
    Guttorm Haraldsen
    Division of Pathology, Oslo University Hospital, 0027 Oslo, Norway
    Trends Immunol 30:227-33. 2009
    ....
  77. doi IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells
    Molly D Smithgall
    Department of Inflammation Research, Amgen Inc, 1201 Amgen Court West, Seattle, WA, USA
    Int Immunol 20:1019-30. 2008
    ..Moreover, the nature of the responses elicited by IL-33 suggests that this axis may amplify both T(h)1- and T(h)2-oriented immune responses...
  78. doi Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
    ..Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair...
  79. pmc Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 206:43-9. 2009
    ....
  80. doi Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses
    Mingcai Li
    Institute of Inflammation and Immune Diseases, Shantou University Medical College, Shantou, China
    J Leukoc Biol 86:23-32. 2009
    ..In this review, we summarize recent findings about the biology of IFN-lambdas and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms...
  81. doi Biology of interleukin-22
    Kerstin Wolk
    University Hospital Charite, Berlin, Germany
    Semin Immunopathol 32:17-31. 2010
    ....
  82. ncbi IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
    Mariola Kurowska-Stolarska
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 183:6469-77. 2009
    ..Taken together, we demonstrate here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation...
  83. pmc Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro
    Shekar Srinivas
    The Institute for Genetic Immunology, Hamilton, NJ 08690, USA
    Immunology 125:492-502. 2008
    ..Thus, IFN-lambda1 appears to be an inhibitor of human Th2 responses whose action is primarily directed towards IL-13 but which may also affect Th2 responses generally and does not invoke a complementary elevation of IFN-gamma secretion...
  84. ncbi Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
    Sean E Doyle
    ZymoGenetics, Inc, Seattle, WA 98102, USA
    Hepatology 44:896-906. 2006
    ..This fact, combined with significant receptor expression in hepatitis virus-infected livers, suggests that IL-29 may have therapeutic value against chronic viral hepatitis in human patients...
  85. ncbi IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    Katia Boniface
    Laboratoire Cytokines et Inflammation, UPRES EA 3806, Pole Biologie Sante, Universite de Poitiers, Poitiers, France
    J Immunol 174:3695-702. 2005
    ..Finally, we show that IL-22 strongly induces hyperplasia of reconstituted human epidermis. Taken together, these results suggest that IL-22 plays an important role in skin inflammatory processes and wound healing...
  86. pmc Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    Caroline Pot
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 183:797-801. 2009
    ..ICOS further promotes IL-27-driven Tr1 cells. Each of those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency of IL-27-induced differentiation of IL-10-producing Tr1 cells...
  87. pmc The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    Beichu Guo
    Department of Microbiology, Immunology, and Molecular Genetics, 8 240 Factor Building, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Clin Invest 118:1680-90. 2008
    ....
  88. ncbi IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, D 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G960-8. 2005
    ....
  89. pmc Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research NCHECR, University of New South Wales UNSW, Sydney, Australia
    Hepatology 52:1216-24. 2010
    ..047). Among participants adherent to treatment and who had IL28B genotyping (n = 54), sustained virologic response was similar among TT homozygotes (18 of 29 participants, 62%) and those with GG/GT genotype (16 of 25, 64%, P = 0.884)...
  90. doi Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
    Ling Yang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Hepatol 53:339-47. 2010
    ..However, it is currently unknown whether IL-22 has an effect on lipid metabolism in the liver...
  91. doi A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    Hans L Tillmann
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Gastroenterology 139:1586-92, 1592.e1. 2010
    ..We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population...
  92. pmc Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
    Suwen Wei
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Leukoc Biol 88:495-505. 2010
    ..Thus, the different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues...
  93. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  94. doi Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Hepatol 53:439-43. 2010
    ..An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American, and European populations, has also been found to be associated with spontaneous eradication of the virus...
  95. ncbi Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
    S C Pflugfelder
    Ocular Surface and Tear Center Bascom Palmer Eye Institute University of Miami School of Medicine Department of Ophthalmology Miami, FL 33136, USA
    Curr Eye Res 19:201-11. 1999
    ..To compare epidermal growth factor (EGF) concentration in tear fluid and levels of inflammatory cytokines in the conjunctival epithelium of patients with Sjögren's syndrome keratoconjunctivitis sicca with those of normal controls...
  96. ncbi IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase
    Georg F Weber
    Chirurgische Klinik und Poliklinik der Technischen Universität München, Ismaningerstrasse 22, 81675 Munich, Germany
    J Immunol 177:8266-72. 2006
    ..Therefore, IL-22 may play a role in the control of tumor growth and tumor progression...
  97. ncbi Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 39:1332-42. 2004
    ....
  98. pmc Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
    Cell Host Microbe 5:476-86. 2009
    ..Thus, resistance to lipocalin-2 defines a specific adaptation of S. Typhimurium for growth in the inflamed intestine...
  99. pmc Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
    K Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Clin Exp Immunol 157:261-70. 2009
    ..In conclusion, IL-17-positive cells are associated with the chronic inflammation of bile ducts in PBC which is associated causally with the biliary innate immune responses to PAMPs...
  100. doi Discovery of a cytokine and its receptor by functional screening of the extracellular proteome
    Haishan Lin
    Five Prime Therapeutics, Inc, 1650 Owens Street, Suite 200, San Francisco, CA 94158, USA
    Science 320:807-11. 2008
    ..This systematic approach is thus useful for discovering new ligands and receptors and assessing the functional selectivity of extracellular regulatory proteins...
  101. pmc IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 207:273-80. 2010
    ..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...

Research Grants92

  1. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Biomedical Simulations Resource (BMSR)
    DAVID D ARGENIO; Fiscal Year: 2009
    ..05/01) Page Biographical Sketch Format Page ..
  4. Biomedical Simulations Resource (BMSR)
    DAVID Z D apos ARGENIO; Fiscal Year: 2010
    ..05/01) Page Biographical Sketch Format Page ..
  5. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..abstract_text> ..
  6. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2009
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  7. DCTD Biopharmaceutical Development - Type 1 Diabetes RAID projects
    LARRY ARTHUR; Fiscal Year: 2009
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  8. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2012
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  9. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2011
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  10. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2010
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  11. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor Amiji; Fiscal Year: 2009
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  12. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  13. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ....
  14. Gene Polymorphism, Infection/Inflammation, Preterm Birth
    Xiaobin Wang; Fiscal Year: 2010
    ..VI. Maternal Questionnaire VII. Medical Record Abstraction Sheet PHS 398 (Rev. 4/98) (Form Page 3} Page 4 Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  15. Functional cloning of S. mansoni egg-specific Th2 cells
    Markus Mohrs; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY NIEVES; Fiscal Year: 2010
    ..The present proposal will investigate the effects of THC, its related compound 2-arachidonoylglycerol and the peripheral cannabinoid receptor on the immune responses to a systemic Candida albicans infection in mice. ..
  17. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY BUCKLEY NIEVES; Fiscal Year: 2009
    ..The present proposal will investigate the effects of THC, its related compound 2-arachidonoylglycerol and the peripheral cannabinoid receptor on the immune responses to a systemic Candida albicans infection in mice. ..
  18. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..We hypothesize that this signaling pathway regulates epithelial, proliferative repair responses after renal injury. If correct, then this would impact on most forms of acute and chronic renal damage. ..
  19. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2009
    ..We hypothesize that this signaling pathway regulates epithelial, proliferative repair responses after renal injury. If correct, then this would impact on most forms of acute and chronic renal damage. ..
  20. OUTCOMES OF HOSPITAL DEDICATED AIDS UNITS
    Linda Aiken; Fiscal Year: 1992
    ..Understanding the roles of cytokines in modulating vascular tone may improve our ability to control these significant complications of human disease...
  21. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2012
    ..Determining the role of IL-10 in mediating fatal viral encephalomyelitis pathology will increase our understanding of the mechanisms responsible for severe and fatal infections and provide a basis for therapeutic development. ..
  22. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..Our preliminary results indicate that Interleukin 10 may be very important to protect the brain blood vessels from damage during this infection. We propose to study this in a mouse model of spirochetal brain infection. ..
  23. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1990
    ....
  24. Effect of SS-associated cytokines on salivary gland dysfunction
    OLGA JULIANA BAKER; Fiscal Year: 2010
    ..We propose to determine the role of pro-inflammatory cytokines in salivary gland tight junction integrity causing reduction of saliva secretion. ..
  25. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2003
    ..1/8.2+ T cells and interferon-gamma, and interleukins-10 and 12 during the inductive phase of vaccination...
  26. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..1/8.2 [unreadable] T cells and interferon-y, and interleukins-10 and 12 during the inductive phase of vaccination...
  27. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
    ..1/8.2+ T cells and interferon-gamma, and interleukins-10 and 12 during the inductive phase of vaccination...
  28. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2004
    ..abstract_text> ..
  29. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2003
    ..abstract_text> ..
  30. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  31. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2000
    ....
  32. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 1999
    ....
  33. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ....
  34. INDUCTION OF CERVICAL RIPENING W/ INTERLEUKIN 8 IN PREGNANT RHESUS MONKEYS
    MILES NOVY; Fiscal Year: 2002
    ..Induction of cervical ripening with interleukin-8 (IL-8) in pregnant rhesus monkeys. In Society for Gynecological Investigation Program and Abstracts 45th Annual Meeting (held in Atlanta, GA, March 11-14, 1998), p 190A (abstract #T615). ..
  35. INDUCTION OF CERVICAL RIPENING W/ INTERLEUKIN 8 IN PREGNANT RHESUS MONKEYS
    MILES NOVY; Fiscal Year: 2001
    ..Induction of cervical ripening with interleukin-8 (IL-8) in pregnant rhesus monkeys. In Society for Gynecological Investigation Program and Abstracts 45th Annual Meeting (held in Atlanta, GA, March 11-14, 1998), p 190A (abstract #T615). ..
  36. INDUCTION OF CERVICAL RIPENING W/ INTERLEUKIN 8 IN PREGNANT RHESUS MONKEYS
    MILES NOVY; Fiscal Year: 1999
    ..Induction of cervical ripening with interleukin-8 (IL-8) in pregnant rhesus monkeys. In Society for Gynecological Investigation Program and Abstracts 45th Annual Meeting (held in Atlanta, GA, March 11-14, 1998), p 190A (abstract #T615). ..
  37. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2010
    ..We now postulate that both systemic, particularly interleukins (interleukin)-1 and -6, and intrarenal (angiotensin II and p38 mitogen activated protein kinase) mediators ..
  38. ESTROGEN REGULATION OF HUMAN INTERLEUKIN 6 GENE PROMOTER
    Sreenivas Koka; Fiscal Year: 1999
    ..Identification of the mechanisms by which estrogen regulates IL-6 gene expression will enhance our understanding of the pathobiology of osteoporosis and suggest future strategies aimed at treating and preventing this disease. ..
  39. ABNORMAL CYTOKINE SYNTHESES IN CUTANEOUS T-CELL LYMPHOMA
    Alain Rook; Fiscal Year: 1993
    ..The scope of these abnormalities is strikingly similar to the in vitro activities of interleukins 4 and 5 (IL-4 & IL-5)...
  40. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    PHILLIP HASHKES; Fiscal Year: 2007
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  41. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    PHILLIP HASHKES; Fiscal Year: 2009
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  42. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  43. Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
    Rebecca M Sappington; Fiscal Year: 2010
    ..We propose a series of studies to examine the potential of the inflammatory cytokine interleukin-6 as a therapeutic target to rescue RGCs in glaucoma. ..
  44. RETINAL CELL/LEUKOCYTE BINDING INDUCES CXC/CC CHEMOKINES
    Victor Elner; Fiscal Year: 2000
    ....
  45. RETINAL CELL/LEUKOCYTE BINDING INDUCES CXC/CC CHEMOKINES
    Victor Elner; Fiscal Year: 2001
    ....
  46. RETINAL CELL/LEUKOCYTE BINDING INDUCES CXC/CC CHEMOKINES
    Victor Elner; Fiscal Year: 2002
    ....
  47. Omega-3 polyunsaturated fatty acid supplementation and allergic diseases in child
    Isabelle Romieu; Fiscal Year: 2009
    ....
  48. EFFECTS OF PHORBOL ESTERS ON LYMPHOCYTE STIMULATION
    Andrea Mastro; Fiscal Year: 1990
    ..The cells will also be tested for suppressor activity...
  49. Development of therapeutic monoclonal antibody to the bioactive lipid lysophospha
    Rosalia Matteo; Fiscal Year: 2009
    ..Discovering the major determinants in cancer progression for the development of more efficacious therapies is therefore extremely important to society. ..
  50. B CELL REGULATION BY INTERLEUKIN-5 + ANTIGEN
    CAROL WEBB; Fiscal Year: 1992
    ....
  51. MATERNAL SERUM INTERLEUKIN 6 IN PRETERM PREMATURE RUPTURE OF MEMBRANES
    Amy Murtha; Fiscal Year: 2001
    ..Future plans: We plan to complete enrollment in this study. ..
  52. MATERNAL SERUM INTERLEUKIN 6 IN PRETERM PREMATURE RUPTURE OF MEMBRANES
    Amy Murtha; Fiscal Year: 1999
    ..Future plans: We plan to complete enrollment in this study. ..
  53. MATERNAL SERUM INTERLEUKIN 6 IN PRETERM PREMATURE RUPTURE OF MEMBRANES
    Amy Murtha; Fiscal Year: 2000
    ..Future plans: We plan to complete enrollment in this study. ..
  54. 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Stavros Manolagas; Fiscal Year: 1991
    ....
  55. Early Life Stress, Developmental Processes, and Adult Health
    JEFFRY ALAN SIMPSON; Fiscal Year: 2011
    ..We believe that modeling and documenting the hypothesized health-related trajectories will result in a more integrated and nuanced understanding of human health and behavior from birth to middle-age. ..
  56. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    John Allman; Fiscal Year: 2009
    ..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B and control groups. ..
  57. CYTOKINE NETWORKS REGULATE RPE LEUKOCYTE CHEMOTAXINS
    Victor Elner; Fiscal Year: 1992
    ....
  58. CYTOKINE NETWORKS REGULATE RPE LEUKOCYTE CHEMOTAXINS
    Victor Elner; Fiscal Year: 1993
    ....
  59. Omega-3 polyunsaturated fatty acid supplementation and allergic diseases in child
    Isabelle Romieu; Fiscal Year: 2010
    ....
  60. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2009
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  61. Modulation of the Immune System to Improve Ligament/Ligament Graft Healing
    RAY contact VANDERBY; Fiscal Year: 2010
    ..Developing these methods (via controlled delivery of inflammatory mediators from biomineral coatings on injectable microspheres) is the goal of this application. ..
  62. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
    ..abstract_text> ..
  63. INTERLEUKIN REGULATION OF PROOPIOMELANOCORTIN GENE
    S Brown; Fiscal Year: 1990
    ..Finally, we will determine if like CRF, monokines and lymphokines stimulate cAMP generation in pituitary cells. These studies will determine if molecules of divergent origin produce common effects through similar mechanisms...
  64. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2005
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  65. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2004
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  66. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2005
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  67. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  68. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2003
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  69. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2002
    ..The role of STAT3 in fat pad formation will be investigated by implantation into the subcutaneous space of nude mice human preadipocytes that express vector, PIAS3, or constitutively active STAT3. ..
  70. Dissecting the Role of IL-12 in Naive CD8+ T cell Activation by Dendritic Cells
    CURTIS HENRY; Fiscal Year: 2007
    ..The findings generated through this work could be translated into the improvement of currently used vaccines and therapeutics against a variety of intracellular pathogens and tumors. [unreadable] [unreadable] [unreadable]..
  71. INTERLEUKIN 5 GENE EXPRESSION AND LUNG INFLAMMATION
    Anuradha Ray; Fiscal Year: 2000
    ..The expression of this gene will be determined in antigen and virus models of airway inflammation in the presence or absence of glucocorticoids. ..
  72. INTERLEUKIN 5 GENE EXPRESSION AND LUNG INFLAMMATION
    Anuradha Ray; Fiscal Year: 1999
    ..The expression of this gene will be determined in antigen and virus models of airway inflammation in the presence or absence of glucocorticoids. ..
  73. CYTOKINE REGULATION OF P450 IN CULTURED RAT HEPATOCYTES
    Joseph Williams; Fiscal Year: 1993
    ..Knowledge of the effects of cytokines on P450 is of utmost importance for understanding alterations in pharmacokinetics during infection or inflammation, as well as during cancer immunotherapy...
  74. Development of Biomaterials that Release Therapeutic Agents to Modulate Inflammat
    Ryan Gilbert; Fiscal Year: 2009
    ..The research described in this proposal will determine if hydrogels loaded with glutathione or interleukin-10 are more effective at reducing secondary injury than injection of these agents in a rat spinal cord injury model. ..
  75. ACTG328 RECOMBINANT HUMAN INTERLEUKIN 2--IV OR SUBCUTANEOUS ADMINISTRATION
    Elizabeth Connick; Fiscal Year: 1999
    ..A subset of subjects will be evaluated for the effect of rhIL-2 on immune cell phenotypes and function and HIV viral load and on rate of development of antiviral drug resistance. ..
  76. ACTG328 RECOMBINANT HUMAN INTERLEUKIN 2--IV OR SUBCUTANEOUS ADMINISTRATION
    Elizabeth Connick; Fiscal Year: 2000
    ..A subset of subjects will be evaluated for the effect of rhIL-2 on immune cell phenotypes and function and HIV viral load and on rate of development of antiviral drug resistance. ..
  77. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..Results will have practical application to IL1-associated brain pathologies including inflammation-associated sleep disturbances occurring in sleep apnea and metabolic syndrome. ..
  78. The Role of Interleukin-4 (IL-4) in the Pathogenesis of Non-Hodgkin's Lymphoma
    JAMES LOUIS RUBENSTEIN; Fiscal Year: 2010
    ....
  79. The Role of Interleukin-4 (IL-4) in the Pathogenesis of Non-Hodgkin's Lymphoma
    James Rubenstein; Fiscal Year: 2009
    ....
  80. BRAIN IL-1 REDUCES CELLULAR IMMUNE RESPONSES--MECHANISM
    JAY WEISS; Fiscal Year: 1992
    ..a) Will TNFalpha or IL-6 produce the same immunological effects in brain as does IL-1? and (b) Do TNFalpha and IL-6 act synergistically with IL-1 in brain to increase (or possibly decrease) immunological effects of IL-1 in brain?..
  81. MODULATORS OF PULMONARY INFLAMMATION & FIBROSIS
    Jack Elias; Fiscal Year: 1991
    ..D. Determination of the cytokine response element(s) of IL-6. We will determine if specific segments in the IL-6 transcript mediate the stabilizing effects of the cytokines...
  82. MODULATORS OF PULMONARY INFLAMMATION & FIBROSIS
    Jack Elias; Fiscal Year: 1990
    ..D. Determination of the cytokine response element(s) of IL-6. We will determine if specific segments in the IL-6 transcript mediate the stabilizing effects of the cytokines...