interferons

Summary

Summary: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.

Top Publications

  1. ncbi Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
    Richard E Randall
    School of Biology, University of St Andrews, The North Haugh, St Andrews KY16 9ST, UK
    J Gen Virol 89:1-47. 2008
  2. ncbi The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    Mitsutoshi Yoneyama
    Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Nat Immunol 5:730-7. 2004
  3. pmc The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein
    Nanette Van Damme
    The San Diego Department of Veterans Affairs Healthcare System, San Diego, CA 92161, USA
    Cell Host Microbe 3:245-52. 2008
  4. ncbi Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 122:669-82. 2005
  5. pmc Interferon-inducible antiviral effectors
    Anthony J Sadler
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Nat Rev Immunol 8:559-68. 2008
  6. pmc 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 468:452-6. 2010
  7. pmc Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:1023-34. 2011
  8. ncbi IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
  9. ncbi Interferons, immunity and cancer immunoediting
    Gavin P Dunn
    Washington University School of Medicine, Department of Pathology and Immunology, Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 6:836-48. 2006
  10. pmc STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 455:674-8. 2008

Detail Information

Publications325 found, 100 shown here

  1. ncbi Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
    Richard E Randall
    School of Biology, University of St Andrews, The North Haugh, St Andrews KY16 9ST, UK
    J Gen Virol 89:1-47. 2008
    ....
  2. ncbi The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    Mitsutoshi Yoneyama
    Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Nat Immunol 5:730-7. 2004
    ..Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes...
  3. pmc The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein
    Nanette Van Damme
    The San Diego Department of Veterans Affairs Healthcare System, San Diego, CA 92161, USA
    Cell Host Microbe 3:245-52. 2008
    ....
  4. ncbi Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 122:669-82. 2005
    ..of the transcription factors NF-kappaB and IRF 3, which coordinately regulate the expression of type-I interferons such as interferon-beta (IFN-beta)...
  5. pmc Interferon-inducible antiviral effectors
    Anthony J Sadler
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Nat Rev Immunol 8:559-68. 2008
    Since the discovery of interferons (IFNs), considerable progress has been made in describing the nature of the cytokines themselves, the signalling components that direct the cell response and their antiviral activities...
  6. pmc 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 468:452-6. 2010
    ..Differential methylation of cytoplasmic RNA probably serves as an example for pattern recognition and restriction of propagation of foreign viral RNA in host cells...
  7. pmc Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:1023-34. 2011
    ..Moreover, we demonstrated that interferons (IFNs) played important roles in regulating IL-1 production by these cells in vivo...
  8. ncbi IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
    ..This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs...
  9. ncbi Interferons, immunity and cancer immunoediting
    Gavin P Dunn
    Washington University School of Medicine, Department of Pathology and Immunology, Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 6:836-48. 2006
    ..The interferons (IFNs) - that is, the type I IFNs (IFNalpha and IFNbeta) and type II IFN (IFNgamma) - have emerged as central ..
  10. pmc STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 455:674-8. 2008
    ..Thus, as well as identifying a regulator of innate immune signalling, our results imply a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA...
  11. pmc SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons
    Corine St Gelais
    Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, 1900 Coffey Road, Columbus, Ohio 43210, USA
    Retrovirology 9:105. 2012
    ..SAMHD1 has been reported as a type I interferon (IFN)-inducible protein, but whether type I IFNs upregulate SAMHD1 expression in primary DCs and CD4+ T-lymphocytes is unknown...
  12. ncbi JAK-STAT signaling: from interferons to cytokines
    Christian Schindler
    Departments of Microbiology and Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 282:20059-63. 2007
  13. pmc Lambda interferon inhibits hepatitis B and C virus replication
    Michael D Robek
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    J Virol 79:3851-4. 2005
    ..These results suggest the possibility that IFN-lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection...
  14. pmc The ISG56/IFIT1 gene family
    Volker Fensterl
    Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Interferon Cytokine Res 31:71-8. 2011
    ..While these genes are normally silent in most cell types, their transcription is strongly induced by interferons, virus infection, and molecular patterns such as double-stranded RNA or lipopolysaccharides...
  15. pmc Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
    M A Garcia
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Ciudad Universitaria Cantoblanco, 28049 Madrid, Spain
    Microbiol Mol Biol Rev 70:1032-60. 2006
    ..protein kinase PKR is a critical mediator of the antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector molecule on the cellular response to double-stranded RNA, but it also integrates ..
  16. pmc IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    Thomas J Urban
    Center for Human Genome Variation, Duke University Medical Center, Durham, NC, USA
    Hepatology 52:1888-96. 2010
    ..IL28B protein sequence variants associated with rs12979860 were therefore investigated in vitro: no differences in ISG induction or inhibition of HCV replication were observed in Huh7.5 cells...
  17. ncbi Interferons at age 50: past, current and future impact on biomedicine
    Ernest C Borden
    Taussig Cancer Center, Case Comprehensive Cancer Center, Mellen Center for Multiple Sclerosis, and Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Rev Drug Discov 6:975-90. 2007
    ..Our goal is to offer a molecular and clinical perspective that will enable IFNs or their TLR agonist inducers to reach their full clinical potential...
  18. pmc Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response
    Christian K Pfaller
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Curr Opin Immunol 23:573-82. 2011
    ....
  19. pmc HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons
    Emmanuel Thomas
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 142:978-88. 2012
    ..the IL28B gene have been associated with clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV infection...
  20. pmc Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo
    Nina Ank
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 80:4501-9. 2006
    Type III interferons (IFNs) (interleukin-28/29 or lambda interferon [IFN-lambda]) are cytokines with IFN-like activities. Here we show that several classes of viruses induce expression of IFN-lambda1 and -lambda2/3 in similar patterns...
  21. ncbi Functional classification of interferon-stimulated genes identified using microarrays
    M J de Veer
    Department of Cancer Biology, Lerner Research Institute, Cleveland, Ohio, USA
    J Leukoc Biol 69:912-20. 2001
    b>Interferons (IFNs) are a family of multifunctional cytokines that activate transcription of subsets of genes. The gene products induced by IFNs are responsible for IFN antiviral, antiproliferative, and immunomodulatory properties...
  22. pmc Inhibition of interferon signaling by dengue virus
    Jorge L Munoz-Jordan
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
    Proc Natl Acad Sci U S A 100:14333-8. 2003
    ..This protein, encoded by a positive strand RNA virus, is implicated as an IFN-signaling inhibitor...
  23. pmc Human TRIM gene expression in response to interferons
    Laetitia Carthagena
    Departement des Maladies Infectieuses, Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    PLoS ONE 4:e4894. 2009
    ..The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity...
  24. pmc Evolutionary genetic dissection of human interferons
    Jeremy Manry
    Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, F 75015 Paris, France
    J Exp Med 208:2747-59. 2011
    b>Interferons (IFNs) are cytokines that play a key role in innate and adaptive immune responses...
  25. pmc Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo
    Nancy A Jewell
    The Research Institute at Nationwide Children s Hospital, and Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH, USA
    J Virol 84:11515-22. 2010
    The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host defense against influenza A virus infection, but we have now discovered that the recently identified type III IFNs (IFN-λ) constitute the major ..
  26. pmc MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness
    Qiong Wang
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 7:e1002070. 2011
    ..These results suggest that, in the context of RV infection, binding of viral dsRNA to MDA5 and TLR3 initiates pro-inflammatory signaling pathways leading to airways inflammation and hyperresponsiveness...
  27. ncbi Pharmacology and therapeutic potential of interferons
    Peter M George
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Pharmacol Ther 135:44-53. 2012
    ..Finally, we look to the future of interferon drug treatment, examining the potential for emerging therapies...
  28. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
    ..Thus, TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAF3...
  29. pmc RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I
    Mayra Solis
    Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 85:1224-36. 2011
    ..This study reveals a novel PR-dependent mechanism employed by HIV-1 to counteract the early IFN response to viral RNA in infected cells...
  30. pmc INTERFEROME: the database of interferon regulated genes
    Shamith A Samarajiwa
    Center for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Nucleic Acids Res 37:D852-7. 2009
    ....
  31. pmc Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism
    Ren Jye Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 80:5908-18. 2006
    ..We suggest that JEV NS5 is an IFN antagonist and that it may play a role in blocking IFN-stimulated Jak-Stat signaling via activation of PTPs during JEV infection...
  32. pmc Establishment, immortalisation and characterisation of pteropid bat cell lines
    Gary Crameri
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    PLoS ONE 4:e8266. 2009
    ..New stable bat cell lines are needed to help with these investigations and as tools to assist in the study of bat immunology and virus-host interactions...
  33. pmc Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    J Virol 78:2701-10. 2004
    ....
  34. ncbi Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells
    M R Khaitov
    Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute of Infection and Immunity and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London, UK
    Allergy 64:375-86. 2009
    ..Rhinoviruses and other respiratory viruses infect both BECs and macrophages, but their relative capacities for alpha-, beta- and lambda-interferon production are unknown...
  35. ncbi Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma
    Ahmed Lasfar
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    Cancer Res 66:4468-77. 2006
    ..IFN-lambda2 cells, suggesting that IFN-lambdas engage host mechanisms to inhibit melanoma growth. These in vivo experiments show the antitumor activities of IFN-lambdas and suggest their strong therapeutic potential...
  36. pmc Genomic analysis of the host response to hepatitis C virus infection
    Andrew I Su
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:15669-74. 2002
    ..Our results reveal genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection...
  37. ncbi Immunologic messenger molecules: cytokines, interferons, and chemokines
    Scott P Commins
    University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:S53-72. 2010
    ..A discussion of chemokine function and their role in cell trafficking and disease follows...
  38. ncbi Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes
    Kui Li
    Department of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    J Biol Chem 280:16739-47. 2005
    ..We conclude that hepatocytes contain two distinct antiviral signaling pathways leading to expression of type I IFNs, one dependent upon TLR3 and the other dependent on RIG-I, with little cross-talk between these pathways...
  39. pmc Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses
    Stephane Biacchesi
    INRA, CRJ, Jouy en Josas, France
    J Virol 83:7815-27. 2009
    ..through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines...
  40. ncbi PML and PML nuclear bodies: implications in antiviral defence
    Roger D Everett
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow, UK
    Biochimie 89:819-30. 2007
    The establishment of an intracellular antiviral state is the defining activity of interferons (IFNs) as well as the property that permitted their discovery...
  41. pmc An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
    Ralph R Weichselbaum
    Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, Marjorie B Kovler Viral Oncology Laboratories, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:18490-5. 2008
    ..By providing information on treatment sensitivity or resistance, the IRDS improves outcome prediction when combined with standard markers, risk groups, or other genomic classifiers...
  42. ncbi The interferons and their receptors--distribution and regulation
    Nicole A de Weerd
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 90:483-91. 2012
    The interferons (IFNs) were originally described over 50 years ago, identified by their ability to confer viral resistance to cells...
  43. pmc USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response
    Véronique François-Newton
    Institut Pasteur, Cytokine Signaling Unit, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Paris, France
    PLoS ONE 6:e22200. 2011
    Type I interferons (IFN) are cytokines that are rapidly secreted upon microbial infections and regulate all aspects of the immune response...
  44. ncbi The role of protein kinase R in the interferon response
    Agnieszka Pindel
    Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    J Interferon Cytokine Res 31:59-70. 2011
    The effects of interferons (IFNs) are mediated through the induction of around 2,000 IFN-stimulated gene (ISG) products...
  45. pmc TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    Cristiana Guiducci
    Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
    Nature 465:937-41. 2010
    ..These findings unveil a new role for self nucleic acid recognition by TLRs and indicate that inhibitors of TLR7 and 9 signalling could prove to be effective corticosteroid-sparing drugs...
  46. ncbi IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties
    Katrin Witte
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, 10117 Berlin, Germany
    Cytokine Growth Factor Rev 21:237-51. 2010
    IL-28A, IL-28B and IL-29 (also designated type III interferons) constitute a new subfamily within the IL-10-interferon family...
  47. ncbi Early antiviral response and virus-induced genes in fish
    Eloi R Verrier
    INRA, Fish Infection and Immunity, Molecular Virology and Immunology, Domaine de Vilvert, 78352 Jouy en Josas, France
    Dev Comp Immunol 35:1204-14. 2011
    ..Most of the ISG-based pathways remain to be directly determined in fish. Fish ISGs are often duplicated and the functional specialization of multigenic families will be of particular interest for future studies...
  48. pmc Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling
    Li Sun
    Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing, China
    PLoS ONE 7:e30802. 2012
    ..These results describe a new mechanism used by CoVs in which CoV PLPs negatively regulate antiviral defenses by disrupting the STING-mediated IFN induction...
  49. pmc Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]
    Kirsten M Spann
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8007, USA
    J Virol 78:4363-9. 2004
    Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta)...
  50. pmc Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA
    Hepatology 54:1913-23. 2011
    ..The level of IFNλ protein induced was sufficient to inhibit HCVcc infection of naïve cultures...
  51. ncbi The interferons: 50 years after their discovery, there is much more to learn
    Sidney Pestka
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Biol Chem 282:20047-51. 2007
    The interferons (IFNs) and their receptors represent a subset of the class 2 alpha-helical cytokines that have been in chordates for millions of years...
  52. pmc Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    Emily C Baechler
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:2610-5. 2003
    ..These results provide insights into the genetic pathways underlying SLE, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway...
  53. pmc Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response
    Robert H Silverman
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NB40, Cleveland, OH 44195, USA
    J Virol 81:12720-9. 2007
  54. ncbi How cells respond to interferons
    G R Stark
    Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Annu Rev Biochem 67:227-64. 1998
    b>Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct...
  55. ncbi Viruses and interferons
    G C Sen
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Annu Rev Microbiol 55:255-81. 2001
    ..As expected of potent cytokines, in addition to their antiviral effects, interferons have profound effects on many aspects of cell physiology...
  56. pmc Antiviral actions of interferons
    C E Samuel
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Clin Microbiol Rev 14:778-809, table of contents. 2001
    Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs...
  57. pmc RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, Singapore, Singapore
    PLoS Negl Trop Dis 5:e926. 2011
    ..Collectively, our studies demonstrate that the intracellular RNA virus sensors (RIG-I, MDA5 and TLR3) are activated upon DV infection and are essential for host defense against the virus...
  58. pmc Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist
    Sonja M Best
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    J Virol 79:12828-39. 2005
    ..Because NS5 may interfere with both innate and acquired immune responses to virus infection, this protein may have a significant role in viral pathogenesis...
  59. ncbi Distinct patterns of cytokine regulation of APOBEC3G expression and activity in primary lymphocytes, macrophages, and dendritic cells
    Kim S Stopak
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 282:3539-46. 2007
    ..Together, these results highlight the distinct inductive effects of select cytokines on A3G gene expression and A3G complex assembly that occur in natural cellular targets of HIV infection...
  60. ncbi Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity
    Otto Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Interferon Cytokine Res 31:79-87. 2011
    ..MxA expression is tightly regulated by type I and type III interferons, requires signal transducer and activator of transcription 1 signaling, and is not inducible directly by ..
  61. ncbi Macrophage polarization and HIV-1 infection
    Edana Cassol
    AIDS Immunopathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Leukoc Biol 87:599-608. 2010
    ..In vivo polarization of MP is likely to span a spectrum of activation phenotypes that may change the permissivity to and alter the outcome of HIV-1 and other viral infections...
  62. ncbi IRF family of transcription factors as regulators of host defense
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 19:623-55. 2001
    ..Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis...
  63. ncbi Molecular regulation of interferon antiviral response in fish
    Yi Bing Zhang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Dev Comp Immunol 38:193-202. 2012
    ..We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed...
  64. pmc Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases
    Zhangle Zhou
    Department of Human Genetics, University of Aarhus, Denmark
    J Virol 81:7749-58. 2007
    ..We also tested the activation of mitogen-activated protein (MAP) kinases by type III IFN and found that type III IFN relies strongly upon both p38 and JNK MAP kinases for gene induction...
  65. pmc The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
    ..HIV-stimulated interferon production in cells deficient in TREX1 did not involve known nucleic acid sensors...
  66. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ..recognition and conceptus development and implantation in sheep with respect to regulation by progesterone, interferons and endogenous retroviruses...
  67. ncbi Induction of an interferon response by RNAi vectors in mammalian cells
    Alan J Bridge
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges, Switzerland
    Nat Genet 34:263-4. 2003
    ..Although siRNAs are thought to be too short to induce interferon expression, we report here that a substantial number of shRNA vectors can trigger an interferon response...
  68. ncbi Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system
    Haizhen Zhu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Gastroenterology 133:1649-59. 2007
    ..However, the interaction between HCV and hepatocyte innate antiviral defense systems is not understood. The aim of this study was to examine how human hepatocytes respond to HCV infection...
  69. pmc Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
    Bin Jia
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA
    PLoS Pathog 5:e1000429. 2009
    ....
  70. ncbi Interferons and viral infections
    Volker Fensterl
    Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Biofactors 35:14-20. 2009
    b>Interferons represent a family of cytokines, which is of central importance in the innate immune response to virus infections...
  71. ncbi The interferon system of teleost fish
    Børre Robertsen
    Department of Marine Biotechnology, Norwegian College of Fishery Science, University of Tromsø, 9037 Tromso, Norway
    Fish Shellfish Immunol 20:172-91. 2006
    b>Interferons (IFNs) are secreted proteins, which induce vertebrate cells into an antiviral state...
  72. ncbi Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Traffic 3:710-7. 2002
    ..As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles...
  73. ncbi The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains
    Dina Aggad
    Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France
    J Immunol 183:3924-31. 2009
    ..Both receptor complexes include a common short chain receptor (CRFB5) and a specific long chain receptor (CRFB1 or CRFB2)...
  74. ncbi Identification of genes selectively regulated by IFNs in endothelial cells
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, Istituto Oncologico Veneto, Via Gattemelata 64, I 35128 Padua, Italy
    J Immunol 178:1122-35. 2007
    ..Moreover, we suggest that quantitative differences in the magnitude of the transcriptional activation of IFN-responsive genes could form the basis for cell-specific transcriptional signatures...
  75. ncbi Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    J E Durbin
    Department of Pathology, New York University School of Medicine, New York 10016, USA
    Cell 84:443-50. 1996
    ..Thus, STAT1 appears to be specific for IFN pathways that are essential for viability in the face of otherwise innocuous pathogens...
  76. ncbi Herpes simplex virus encephalitis in human UNC-93B deficiency
    Armanda Casrouge
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, INSERM, U550, Faculte de Medecine Necker, Paris 75015, France
    Science 314:308-12. 2006
    ..HSE can result from a single-gene immunodeficiency that does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Other severe infectious diseases may also reflect monogenic disorders of immunity...
  77. pmc Hepatitis C virus reveals a novel early control in acute immune response
    Noëlla Arnaud
    Institut Pasteur, Hepacivirus and Innate Immunity, Paris, France
    PLoS Pathog 7:e1002289. 2011
    ..Among those, ISG15 acts to negatively control the RIG-I/MAVS pathway, at the level of RIG-I ubiquitination.These data give novel insights in the machinery involved in the early events of innate immune response...
  78. pmc Induction of interferon-stimulated genes by Simian virus 40 T antigens
    Abhilasha V Rathi
    Department of Biological Sciences, University of Pittsburgh, 559 Crawford Hall, Pittsburgh, PA 15260, USA
    Virology 406:202-11. 2010
    ..Our genetic studies using several TAg-mutants reveal an unexplored function of TAg and indicate that the LXCXE motif and p53 binding are required for the upregulation of ISGs...
  79. ncbi Interferons as therapeutic agents for infectious diseases
    Scott J Bergman
    Department of Pharmacy Practice, Southern Illinois University Edwardsville SIUE School of Pharmacy, Edwardsville, IL 62026, USA
    Infect Dis Clin North Am 25:819-34. 2011
    This article explains the rationale for development of interferons as therapeutic agents, and describes commercial products available today...
  80. ncbi Viral evasion and subversion of pattern-recognition receptor signalling
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 8:911-22. 2008
    ..and the description of the molecular basis of their signalling pathways, which lead to the production of interferons and other cytokines...
  81. pmc Inborn errors of anti-viral interferon immunity in humans
    Vanessa Sancho-Shimizu
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, U980, Necker Medical School, Paris 75015, France
    Curr Opin Virol 1:487-96. 2011
    ..These recent discoveries highlight the importance of human type I and III IFNs in protective immunity against viruses, including the TLR3-IFN pathway in protection against HSE...
  82. ncbi Limited use of interleukin 28B in the setting of response-guided treatment with detailed on-treatment virological monitoring
    Alessandra Mangia
    Liver Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Hepatology 54:772-80. 2011
    ..Few CC patients remained viremic beyond week 8 to allow the analysis of relationships between IL28B type and extended treatment...
  83. pmc The C-terminal 42 residues of the Tula virus Gn protein regulate interferon induction
    Valery Matthys
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 85:4752-60. 2011
    ..Thus, in addition to IFN regulation, hantaviruses contain discrete virulence determinants which permit them to be human pathogens...
  84. ncbi Genetic variants of interferon-stimulated genes and IL-28B as host prognostic factors of response to combination treatment for chronic hepatitis C
    R Lopez-Rodriguez
    Liver Unit, Gastroenterology Service, Hospital Universitario de la Princesa, Instituto de Investigación Sanitario Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Clin Pharmacol Ther 90:712-21. 2011
    ..74). In conclusion, ISG SNPs could constitute a valuable tool for individualizing CHC therapy...
  85. ncbi Remodelling of the ubiquitin-proteasome system in response to interferons
    Ulrike Seifert
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, CCM Campus Charité Mitte, Monbijoustrasse 2, 10117 Berlin, Germany
    Biochem Soc Trans 36:879-84. 2008
    ..system) is rate-limiting in MHC class I-restricted antigen presentation in response to virus-induced IFNs (interferons). In this process, the role of IFN-induced rapid remodelling of the UPS is less defined...
  86. ncbi Interferons and microRNAs
    Michael David
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0322, USA
    J Interferon Cytokine Res 30:825-8. 2010
    ..that are adapted to specific viral antigens, and also employ nonadaptive defenses, such as production of interferons (IFNs) that block viral replication and stimulate the host immune response...
  87. ncbi Interferons and osteosarcoma
    Hans Strander
    Department of Oncology Radiumhemmet, Karolinska Institute and Hospital, S 17176, Stockholm, Sweden
    Cytokine Growth Factor Rev 18:373-80. 2007
    ..The trial is briefly outlined in this article...
  88. ncbi Poxviruses and immune evasion
    Bruce T Seet
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    Annu Rev Immunol 21:377-423. 2003
    ..Poxviruses target many of the primary mediators of innate immunity including interferons, tumor necrosis factors, interleukins, complement, and chemokines...
  89. ncbi Viral suppression of the interferon system
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:836-42. 2007
    Type I interferons (IFN-alpha/beta) were originally discovered by their strong and direct antiviral activity [A. Isaacs, J. Lindenmann, Virus interference. I. The interferon, Proc. R. Soc. Lond. B Biol. Sci. 147 (1957) 258-267]...
  90. ncbi Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist
    Z Chen
    Department of Veterinary Science, South Dakota State University, Brookings, SD 57007, USA
    Virology 398:87-97. 2010
    ..These findings provide important insights into mechanisms of nsp1 in PRRSV pathogenesis and its impact in vaccine development...
  91. pmc Antiviral response in pandemic influenza viruses
    Adolfo Garcia-Sastre
    Mount Sinai School of Medicine, New York, New York 10028, USA
    Emerg Infect Dis 12:44-7. 2006
    ....
  92. ncbi Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties
    Baojian Sun
    Department of Marine Biotechnology, Norwegian College of Fishery Science, University of Tromsø, N 9037 Tromsø, Norway
    Dev Comp Immunol 33:547-58. 2009
    ..IFNc genes showed expression patterns different from both IFNa and IFNb. Taken together, salmon IFNa and IFNb are not orthologs of mammalian IFN-beta and IFN-alpha, respectively, but appear to utilize similar induction pathways...
  93. ncbi Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
    Fuller W Bazer
    Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Biol 8:179-211. 2008
    Type I and/or type II interferons (IFNs) are important in establishing uterine receptivity to implantation in mammals. Gene expression effected by IFNs may be induced, stimulated or inhibited, but most are IFN-stimulated genes (ISGs)...
  94. ncbi Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines
    K Witte
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Genes Immun 10:702-14. 2009
    ....
  95. pmc Interferons direct an effective innate response to Legionella pneumophila infection
    Courtney R Plumlee
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    J Biol Chem 284:30058-66. 2009
    ..pneumophila. Surprisingly, this suppression is mediated by a pathway that is independent of Stat1, Stat2, Stat3, but correlates with the polarization of macrophages toward the M1 or classically activated phenotype...
  96. ncbi Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
    T Holtschke
    Institute of Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Cell 87:307-17. 1996
    ..These results suggest a novel role for ICSBP in regulating the proliferation and differentiation of hematopoietic progenitor cells...
  97. pmc PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex
    M C Bonnet
    Unité de Virologie et d Immunologie Cellulaire, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Cell Biol 20:4532-42. 2000
    ..Therefore, our results reveal a novel pathway by which PKR can modulate the NF-kappaB signaling pathway without using its kinase activity...
  98. ncbi Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein
    Yasuhiro Itsui
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatology 50:1727-37. 2009
    b>Interferons (IFNs) and the interferon-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection...
  99. pmc How cells respond to interferons revisited: from early history to current complexity
    George R Stark
    Department of Molecular Genetics, Cleveland Clinic, Cleveland OH 44195, United States
    Cytokine Growth Factor Rev 18:419-23. 2007
    ..I then outline the complex responses of cells to interferons, including the roles of kinases other than JAKs and transcription factors other than STATs, differential ..
  100. pmc Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridization
    R Patzwahl
    Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Georg August Universitat, D 37075 Gottingen, Germany
    J Virol 75:1332-8. 2001
    ..The data on enhanced expression of IFN-alpha/beta inducible genes might be germane to therapeutic considerations...
  101. pmc Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction
    Matthias Habjan
    Department of Virology, University of Freiburg, Freiburg, Germany
    PLoS ONE 3:e2032. 2008
    ....

Research Grants73

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ....
  5. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..Furthermore, the accompanying mentoring and course work will prepare Dr. Assassi to become an independent and productive clinician scientist and a leader in rigorously designed and conducted translational research in rheumatic diseases. ..
  6. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..With our rich Native American heritage and large rural populations, the patients provided by the Oklahoma ACE will be previously understudied and provide unique insights for therapeutic trials. ..
  7. MODULATION OF IFN ACTION VIA NOVEL REGULATORY FACTORS
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
  8. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  9. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..The investigators have preliminary evidence to demonstrate that acrolein, at nontoxic concentrations, significantly down-regulates IFN1 signaling and antiviral/anti-HCV gene expression. ..
  10. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
  11. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..Alternatively, mediators of neuropathogenesis can be targeted to alleviate collateral damage and thus, preservation of neurons in patients that suffer from acute or recurrent HSV-1 CNS or peripheral nerve infection. ..
  12. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..In this grant I wil study the function of a genetic variant associated with multiple autoimmune diseases, the PTPN22 1858T variant, to examine its role in immune responses and disease pathogenesis. ..
  13. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..Inducers of type I interferons (IFN) typically are targets of innate immune antagonists...
  14. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..This is an exciting area of research that could benefit the veterans that make a large portion of the general smoking population. ..
  15. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..The long-range goal of our research is to understand the role of -defensins in the innate immune defense against viruses so that novel therapies can be developed from our findings. ..
  16. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..5 fold drop in viral load without any emergence of resistant virus (Lanford et al. 2010. Science: 327:198-201). ..
  17. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  18. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..This information will be important since the primary goal of our genetic-based investigations is to identify susceptible groups for targeted therapeutic interventions. ..
  19. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    ....
  20. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..abstract_text> ..
  21. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..of M? and microglia, infection with HIV-1 triggers an innate immune response that includes production of interferons (IFNs)...
  22. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..This important new knowledge will reveal virus-induced changes at the post-translational level, and is predicted to provide mechanistic insight into new strategies through which to treat chronic HBV infection and prevent liver disease. ..
  23. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ....
  24. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..abstract_text> ..
  25. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..
  26. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2013
    ..Furthermore, these studies will lead to critical information about use of interferons or inhibitors of autophagy as therapeutic agents for aplastic anemia and myelosuppression due to severe viral ..
  27. Structure and Function of the Hepatitis C Virus Genome
    Peter Sarnow; Fiscal Year: 2013
    ..To do this, novel biochemical, structural and genetic approaches will be employed to study protein-HCV RNA interactions. ..
  28. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  29. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..In addition, understanding the significance of the presence of bacteria in lungs being considered for donation may have serious implications on donor organ utilization. ..
  30. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..Understanding the differences in autoimmune disease risk in men and women, and how hormones affects autoimmunity may lead to novel hormone-based therapies, and insights into this essential riddle in autoimmune disease. ..
  31. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..This research proposal intends to develop intracellular immunization strategy to inhibit HCV. If these experiments are successful it can potentially lead to a therapy for chronic HCV infection and prevent liver cancer. ..
  32. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
  33. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    ..Prevention and/or elimination of chronic liver disease will reduce the risk of HBV carriers developing cirrhosis and liver cancer, thereby contributing centrally to improving public health. ..
  34. Control of alphavirous replacation in the nervous system
    Diane E Griffin; Fiscal Year: 2013
    ....
  35. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    ....
  36. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..of viral upper respiratory infections (URIs) and b) changes in nasal expression of viral adhesion proteins and interferons. 2...
  37. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..Therefore, we propose inhibiting CXCL13 using a human monoclonal antibody. The primary clinical outcome will again be adverse events. The primary mechanistic outcome will be changes in peripheral blood memory B cells. ..
  38. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..This design would dramatically lower the cost of immunotherapy compared cellular vaccines. They are easily synthesized, versatile and can potentially target later stage cancers by using inducing anti-tumor immunity over the whole body. ..
  39. Pathogenic Mechanisms of PBEF in Ventilator Induced Lung Injury
    Joe G N Garcia; Fiscal Year: 2012
    ..Using a systems biology-like approach (genes to populations), we have identified PBEF as a novel biomarker and candidate gene in ALI with genetic variants associated with sepsis and ALI susceptibility ..
  40. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011
    ..The goals are to clarify potential causative mechanisms and discern how these are altered by therapeutic interventions with the aim of developing better therapeutic interventions for mood disorders. ..
  41. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..It is anticipated that a new live HSV-2 ICP0- vaccine strain will emerge from these studies that warrants advancement to human clinical trials. ..
  42. Immune Mechanisms That Control Ectromelia Virus Infection
    Luis J Sigal; Fiscal Year: 2013
    ..Project 2 continues inspection of innate/natural immunity by examining the mechanisms by which type 1 interferons limit spread of the virus beyond the draining lymph node...
  43. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..The present proposal will investigate the effects of THC, its related compound 2-arachidonoylglycerol and the peripheral cannabinoid receptor on the immune responses to a systemic Candida albicans infection in mice. ..
  44. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..Aim 1 of this grant will study the effect of lung derived interferons in BM cells during a well characterized model of mice infection with Sendai virus, and the consequences of this ..
  45. Pathogenesis of Subtype IE Venezuelan Equine Encephalitis Virus
    ALISON PAIGE ADAMS; Fiscal Year: 2012
    ..e., vaccines, therapeutics, and other human disease control measures). ..
  46. Novel Functions of S1P in Neuroinflammation
    TOMASZ K KORDULA; Fiscal Year: 2013
    ..This proposal will enhance understanding of how the intricate interplay between IL-1, S1P and its receptors in astrocytes regulates inflammation and could pave the way for the design of even more effective MS therapies. ..
  47. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..This knowledge will help to understand why autoimmune diseases preferentially afflict women. ..
  48. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2013
    ..The goal of the proposed grant will provide a better understanding of how HCV recognizes and enter cells. This information will be valuable for designing new therapies or a vaccine against HCV. ..
  49. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..abstract_text> ..
  50. Analysis of NKLAM: A Novel Gene Associated With Cellular Cytotoxicity
    Jacki Kornbluth; Fiscal Year: 2013
    ..A variety of tumor models will be evaluated to determine where NKLAM plays a role. Analysis of NKLAM KO mice may reveal additional roles for NKLAM and potentially unveil alternative mechanisms of cell killing. ..
  51. Antisense Mediated Treatment of Hepatitis B Virus Infection
    STEFAN FRANK WIELAND; Fiscal Year: 2013
    ..The work described in this proposal will exploit current and novel in vivo model systems to discover improved, safe and effective antiviral drugs to alleviate the human suffering and socioeconomic burden of this threat to public health. ..
  52. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..The benefit of such a strategy would impact the frequent recurrence of metastases of dormant tumor cells after conventional chemotherapy regimens that can cause tumor relapse and therapeutic failure. ..
  53. Murine coronavirus neurovirulence: role of type I interferon response
    Susan R Weiss; Fiscal Year: 2013
    ..Moreover, understanding type I IFN signaling in the CNS may aid in developing or refining therapeutic applications for type I IFNs, which are currently used in treatment of MS and hepatitis C. ..
  54. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
    ..aeruginosa and respiratory viruses synergize to cause lung disease and, ultimately, identify new therapeutic approaches to control combined P. aeruginosa and respiratory virus infections. ..
  55. Mechanisms of viral proteases in coronavirus replication and pathogenesis
    Andrew D Mesecar; Fiscal Year: 2013
    ..The results from this research will allow us to identify critical sites that mediate specificity of papain-like proteases and provide new insight into viral mechanisms for pathogenesis and evasion of the innate immune response. ..
  56. Sex chromosome aneuploidies in autoimmune disease
    R Hal Scofield; Fiscal Year: 2013
    ..In Specific Aim 2, we will determine differential interferon production as mediated by DDX3X by women versus men. In the final Specific aim, we will comprehensively study the importance of DDX3X in knock-out animals. ..
  57. HLA class II transgenic mouse models for S. aureus infections and superantigens
    Govindarajan Rajagopalan; Fiscal Year: 2013
    ..This will be investigated by a series of in vivo studies using transgenic mice expressing HLA-DR2, HLA-DR3, HLA-DR4, HLA-DQ2, HLA-DQ6 or HLA-DQ8 molecules. ..
  58. Alternative regulation of ISGs in WNV-infected cells
    Margo A Brinton; Fiscal Year: 2013
    ..Delineation of the viral counteraction mechanism will provide a new cell target for the development of antiviral therapeutics that may be applicable to a broad spectrum of virus infections. ..
  59. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas M Moran; Fiscal Year: 2010
    ..This will allow us to observe both the interferon dependent and independent activation that occurs in the bone marrow during virus infection. ..
  60. HCV Strain Variation and HCC
    Andrea D Branch; Fiscal Year: 2012
    ....
  61. The functions of the US3 protein kinase of herpes simplex virus
    Bernard Roizman; Fiscal Year: 2011
    ....
  62. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..Understanding how the immune system supports hematopoiesis is needed to develop strategies for the prevention and treatment of pancytopenia in AIDS patients. ..
  63. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  64. Long Acting Beta Interferon for Treating Multiple Sclerosis - Phase II Continuing
    George Cox; Fiscal Year: 2009
    ..This protein may provide Multiple Sclerosis patients with a more effective and more convenient therapy for the treatment their disease. ..
  65. Interferon-gamma To Treat Chronic HCV Infection
    Andrew Muir; Fiscal Year: 2002
    ..Secondary endpoints include the biochemical response, inflammatory and regulatory cytokine levels, and quality of life during treatment. ..
  66. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2005
    ..therapy has been shown to be superior to interferon monotherapy and preliminary data indicate pegylated interferons are superior to standard interferons...
  67. IMMUNOREGULATORY EFFECTS OF THE INTERFERONS
    Howard Ozer; Fiscal Year: 1992
    The interferons mediate a wide variety of biologic functions, including the ability to induce differentiation, inhibit normal and tumor cell growth, and reverse the action of several oncogenes; we hypothesize that they function as ..
  68. HOST CELL INTERACTION OF ANIMAL VIRUSES
    Philip Marcus; Fiscal Year: 1990
    ....
  69. CLONING OF THE HUMAN RECEPTOR FOR ALPHA-2-INTERFERON
    LINVILLE MEADOWS; Fiscal Year: 1990
    b>Interferons possess many biologic functions, including the ability to induce differentiation, decrease cell growth, and reverse the action of several oncogenes; they function as negative growth regulators...
  70. INTERFERON EFFECTS ON INTERMEDIATE FILAMENTS IN TUMOR CE
    DIANNE BUCKMAN; Fiscal Year: 1992
    DESCRIPTION (Adapted from the applicant's abstract): The interferons (IFN) are a family of naturally occurring glycoproteins which can elicit both an antiviral and an antiproliferative response in cells...
  71. ROLE OF A-INTERFERON RECEPTOR IN HUMAN IMMUNOREGULATION
    Sharon Evans; Fiscal Year: 1992
    ..Thus, studies investigating the basic mechanisms of IFN involved in immunoregulation should clearly provide insight into the interaction of IFN with malignant cells from both IFN-sensitive and resistant patients...
  72. INTERFERON RECEPTORS IN ORGAN TRANSPLANTATION
    Verna Gibbs; Fiscal Year: 1999
    ..The interferons, interferon-gamma (IFN-gamma), interferon-alpha (IFN- alpha) and interferon-Beta (IFN-beta) are secreted ..
  73. PATHOBIOLOGY OF HEPATITIS B VIRUS
    ROBERT SCHLOEMER; Fiscal Year: 1990
    ..ascertain whether the same segment of HBV DNA would be responsible for the suppression of both alpha and beta- interferons and does so by similar mechanisms...