endothelin 3

Summary

Summary: A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)

Top Publications

  1. pmc A heterozygous endothelin 3 mutation in Waardenburg-Hirschsprung disease: is there a dosage effect of EDN3/EDNRB gene mutations on neurocristopathy phenotypes?
    V Pingault
    J Med Genet 38:205-9. 2001
  2. ncbi Contribution of RET, NTRK3 and EDN3 to the expression of Hirschsprung disease in a multiplex family
    A Sánchez-Mejías
    Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Hospital Universitario Virgen del Rocio, Seville, Spain
    J Med Genet 46:862-4. 2009
  3. ncbi Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling
    Nadege Bondurand
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 133:2075-86. 2006
  4. pmc Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor
    E Dupin
    Institut d Embryologie Cellulaire et Moleculaire, Centre National de la Recherche Scientifique FRE 2160, 49 bis Avenue Belle Gabrielle, 94736 Nogent sur Marne Cedex, France
    Proc Natl Acad Sci U S A 97:7882-7. 2000
  5. ncbi The endothelin axis: a novel target for pharmacotherapy of female malignancies
    Martin Smollich
    Department of Obstetrics and Gynecology, University of Munster, D 48145 Münster, Germany
    Curr Vasc Pharmacol 5:239-48. 2007
  6. ncbi Endothelins may modulate invasion and proliferation of Ewing's sarcoma and neuroblastoma
    Paul Berry
    Division of Cancer Medicine, Cancer Research U K Clinical Centre, St James s University Hospital, Leeds LS9 7TF, U K
    Clin Sci (Lond) 103:322S-326S. 2002
  7. ncbi Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells
    De Jun Sun
    Gene Therapy Program, Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Hum Pathol 38:1047-56. 2007
  8. ncbi Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model
    Roman J Garcia
    Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA
    J Invest Dermatol 128:131-42. 2008
  9. pmc Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum
    M A Leibl
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    Gut 44:246-52. 1999
  10. ncbi Cooperative and indispensable roles of endothelin 3 and KIT signalings in melanocyte development
    Hitomi Aoki
    Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
    Dev Dyn 233:407-17. 2005

Detail Information

Publications176 found, 100 shown here

  1. pmc A heterozygous endothelin 3 mutation in Waardenburg-Hirschsprung disease: is there a dosage effect of EDN3/EDNRB gene mutations on neurocristopathy phenotypes?
    V Pingault
    J Med Genet 38:205-9. 2001
  2. ncbi Contribution of RET, NTRK3 and EDN3 to the expression of Hirschsprung disease in a multiplex family
    A Sánchez-Mejías
    Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Hospital Universitario Virgen del Rocio, Seville, Spain
    J Med Genet 46:862-4. 2009
    ..Although HSCR commonly appears as a sporadic trait, approximately 20% of HSCR cases are familial, with complex patterns of inheritance...
  3. ncbi Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling
    Nadege Bondurand
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 133:2075-86. 2006
    The transcriptional regulator SOX10 and the signalling molecule endothelin 3 have important roles in the development of the mammalian enteric nervous system (ENS)...
  4. pmc Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor
    E Dupin
    Institut d Embryologie Cellulaire et Moleculaire, Centre National de la Recherche Scientifique FRE 2160, 49 bis Avenue Belle Gabrielle, 94736 Nogent sur Marne Cedex, France
    Proc Natl Acad Sci U S A 97:7882-7. 2000
    Functional signaling of endothelin 3 (ET3) and its receptor B (ETRB) has been shown to be required for the development of neural crest (NC)-derived pigment cells in mouse, but the precise role of ET3 is not completely understood...
  5. ncbi The endothelin axis: a novel target for pharmacotherapy of female malignancies
    Martin Smollich
    Department of Obstetrics and Gynecology, University of Munster, D 48145 Münster, Germany
    Curr Vasc Pharmacol 5:239-48. 2007
    ..Targeting the ET axis via ET(A)R or ECE blockade seems to be a promising approach in the treatment of female malignancies...
  6. ncbi Endothelins may modulate invasion and proliferation of Ewing's sarcoma and neuroblastoma
    Paul Berry
    Division of Cancer Medicine, Cancer Research U K Clinical Centre, St James s University Hospital, Leeds LS9 7TF, U K
    Clin Sci (Lond) 103:322S-326S. 2002
    ..The ET-3 ligand and ET-B receptor may be associated with migration and metastasis of ES and NBL, whereas ET-1 (acting through the ET-A receptor) may regulate their proliferation...
  7. ncbi Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells
    De Jun Sun
    Gene Therapy Program, Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Hum Pathol 38:1047-56. 2007
    ..These results suggest that the reduction of ET-3 growth factor levels may be important in the transition from normal to cancerous cervical epithelium...
  8. ncbi Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model
    Roman J Garcia
    Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA
    J Invest Dermatol 128:131-42. 2008
    b>Endothelin 3 (Edn3) encodes a ligand important to developing neural crest cells and is allelic to the spontaneous mouse mutation occurring at the lethal spotting (ls) locus...
  9. pmc Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum
    M A Leibl
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    Gut 44:246-52. 1999
    Mutations in endothelin 3 (EDN3) and endothelin B receptor (EDNRB) genes cause terminal colonic aganglionosis in mice, and mutations in these genes have also been linked to the terminal aganglionosis seen in human Hirschsprung's disease...
  10. ncbi Cooperative and indispensable roles of endothelin 3 and KIT signalings in melanocyte development
    Hitomi Aoki
    Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
    Dev Dyn 233:407-17. 2005
    ..During the 21-day period necessary for the induction of mature melanocytes from undifferentiated ES cells, endothelin 3 (EDN3), a ligand for EDNRB, increased the number of melanocytes in proportion to the period during which it was ..
  11. ncbi Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways
    G Mazzocchi
    Department of Anatomy, University of Padua, Italy
    Endocrinology 138:2333-7. 1997
    ....
  12. ncbi Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death
    Tatsurou Yagami
    Discovery Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, Osaka 553 0002, Japan
    Brain Res 948:72-81. 2002
    ..In conclusion, ET(B) receptor agonists exhibit a protective effect against neurotoxicity of Abeta. Furthermore, these agonists appear to act as anti-apoptotic factors by blocking of L-VSCCs...
  13. ncbi Modulatory effect of endothelin-1 and -3 on neuronal norepinephrine release in the rat posterior hypothalamus
    Andrea S di Nunzio
    Cátedra de Fisiología Instituto de Química y Metabolismo del Fármaco Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956 Piso 7, 1113, Buenos Aires, Argentina
    Regul Pept 118:51-9. 2004
    ..Both ETs would enhance the sympathoexcitatory response elicited by the posterior hypothalamus and thus participate in cardiovascular regulation...
  14. ncbi Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells
    Michael J Ryan
    Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
    Am J Physiol Heart Circ Physiol 283:H2458-65. 2002
    ..With the use of a renin-luciferase reporter system in As4.1 cells, ET-1 reduced luciferase activity by 51%, suggesting that renin gene transcription is directly modified by ET-1...
  15. ncbi Regulation of vasopressin secretion by ETA and ETB receptors in compartmentalized rat hypothalamo-neurohypophysial explants
    Noreen F Rossi
    Deptartments of Medicine and Physiology, Wayne State University School of Medicine, 4160 John R 908, Detroit, MI 48201, USA
    Am J Physiol Endocrinol Metab 286:E535-41. 2004
    ..The integration of these excitatory and inhibitory inputs endows the vasopressinergic system with greater plasticity in its response to physiological and pathophysiological states...
  16. ncbi [Endothelin---biosynthesis, function and role in cardiovascular diseases]
    Daniel Piotr Potaczek
    II Katedra Chorób Wewnetrznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
    Pol Arch Med Wewn 108:703-14. 2002
  17. ncbi Possible therapeutic role of endothelin antagonists in cardiovascular disease
    C Venkata S Ram
    Texas Blood Pressure Institute, Dallas Nephrology Associates, and University of Texas Southwestern Medical Center, Dallas, Texas 75240, USA
    Am J Ther 10:396-400. 2003
    ..Preliminary experimental and clinical studies reveal a role played by endothelin as a pathogenetic substance and, conversely, a possible role for endothelin antagonism in clinical medicine...
  18. ncbi Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation
    K Reid
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Development 122:3911-9. 1996
    Melanocytes in the skin are derived from the embryonic neural crest. Recently, mutations in endothelin 3 and the endothelin receptor B genes have been shown to result in gross pigment defects, indicating that this signalling pathway is ..
  19. ncbi Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats
    Mika Ikebe
    Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Nephron Exp Nephrol 94:e137-45. 2003
    ..Although endothelin (ET) 1 can cause natriuresis or antinatriuresis, the role played by ET-1 in proteinuria and in sodium retention due to nephrotic syndrome remains unclear...
  20. ncbi Unique endothelin receptor binding in kidneys of ETB receptor deficient rats
    Traci A Taylor
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Physiol Regul Integr Comp Physiol 284:R674-81. 2003
    ..In addition, homozygous ETB-deficient rats express a novel inner medullary ET-3 binding site...
  21. ncbi Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs
    Hiroko Kitamura
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuramoto cho 3 18 15, Tokushima 770 8503, Japan
    Eur J Pharmacol 465:31-8. 2003
    ..This unique quasi-irreversibility may explain the slow-onset and long-lasting biologic effects of this peptide in vivo...
  22. ncbi Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors
    J J Wu
    Department of Anatomy and Cell Biology and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Development 126:1161-73. 1999
    ....
  23. ncbi Endothelin and neural crest development
    H Kurihara
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 45:639-51. 1999
    ....
  24. ncbi Endothelin-induced modulation of neuropeptide Y and norepinephrine release from the rat mesenteric bed
    Dan Hoang
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Missouri 63104, USA
    Am J Physiol Heart Circ Physiol 283:H1523-30. 2002
    ..These results are consistent with the idea that sympathetic cotransmitters can be preferentially modulated by paracrine mediators at the vascular neuroeffector junction...
  25. ncbi The neurogenic vasodilator response to endothelin-1: a study in human skin in vivo
    R Katugampola
    Allergy and Inflammation Sciences, School of Medicine, University of Southampton, UK
    Exp Physiol 85:839-46. 2000
    ..There appears to be little evidence for the involvement of mast cell-derived histamine in the initiation or modulation of ET-induced vasodilatation, in vivo...
  26. ncbi Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy
    J P Cullen
    Department of Therapeutics and Pharmacology, Centre for Cardiovascular and Genetics Research, School of Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Northern Ireland, Belfast BT9 7BL, UK
    Eur J Pharmacol 417:157-68. 2001
    ....
  27. ncbi EDNRB/EDN3 and Hirschsprung disease type II
    A S McCallion
    Johns Hopkins University, McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland 21287, USA
    Pigment Cell Res 14:161-9. 2001
    ..Mutations in the genes encoding the endothelin type-B receptor (EDNRB) and its physiological ligand endothelin 3 (EDN3) are now known to account for the majority of HSCR II patients...
  28. ncbi Regulation of agonist binding to rat ET(B) receptors by cations and GTPgammaS
    F Ceccarelli
    Department of Psychiatry, University of Pisa, Italy
    Biochem Pharmacol 62:537-45. 2001
    ..In the presence of 5 mM MgCl2 or 50 mM NaCl, a partial regulation of 125I-ET-1 binding by GTPgammaS was detectable, while in the absence of cations no GTPgammaS-dependent inhibition was evident...
  29. ncbi Endocardial expression and functional characterization of endothelin-1
    O Saetrum Opgaard
    Department of Internal Medicine, University Hospital, Lund, Sweden
    Mol Cell Biochem 224:151-8. 2001
    ....
  30. ncbi Naftidrofuryl exerts antiserotonergic but no endothelin-receptor blocking effects in AS4.1 cells, juxtaglomerular cells and isolated perfused rat kidneys
    Dierk Endemann
    Department of Medicine II, University of Regensburg, Regensburg, Germany
    J Cardiovasc Pharmacol 39:1-8. 2002
    ..The present results suggest that naftidrofuryl is a potent antagonist of serotonin's renal effects, but has no endothelin receptor-blocking properties...
  31. ncbi Evidence for altered ETB receptor characteristics during development and progression of ventricular cardiomyocyte hypertrophy
    Graham R Lee
    Department of Therapeutics and Pharmacology, Centre for Cardiovascular and Genetics Research, School of Medicine, Queen s University of Belfast, Whitla Medical Bldg, 97 Lisburn Rd, Belfast BT9 7BL, Northern Ireland, UK
    Am J Physiol Heart Circ Physiol 287:H425-32. 2004
    ....
  32. ncbi Endothelins regulate mediator production of rat tissue-cultured mucosal mast cells. Up-regulation of Th1 and inhibition of Th2 cytokines
    Martin Coulombe
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, 2725 Chemin Sainte Foy, Sainte Foy, Quebec, Canada G1V 4G5
    J Leukoc Biol 71:829-36. 2002
    ..Thus, our data suggest that ETs may play an important role in modulating the cytokine network by regulating Th1/Th2 cytokine production by mast cells...
  33. ncbi Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific
    Z Shraga-Levine
    Department of Neurobiochemistry, Tel Aviv University, Israel
    Cell Mol Neurobiol 20:305-17. 2000
    ..4. It remains to be established whether this diversity of receptor-G protein coupling is of relevance for the various endothelin signaling pathways and/or pathological states...
  34. ncbi Functional cross-talk of Ca2+-mobilizing endothelin receptors in C6 glioma cells
    R Malik
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Physiol Res 51:73-8. 2002
    ..The pattern and/or functional parameters of endothelin receptors in C6 rat glioma cells are modified by cell differentiation...
  35. ncbi Endothelin-mediated calcium signaling in preglomerular smooth muscle cells
    A C Schroeder
    Louisiana State University, School of Medicine, New Orleans 70112, USA
    Hypertension 35:280-6. 2000
    ..Furthermore, these results suggest that ET-1 increases [Ca(2+)](i) by stimulating both the release of intracellular calcium and the influx of calcium from the extracellular medium...
  36. ncbi Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism
    Bilal Ayach
    Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, 2725 Chemin Ste Foy, Ste Foy, QC G1V 4G5, Canada
    Clin Sci (Lond) 103:371S-375S. 2002
    ..These results show that ET(A)-R subtype is involved in the pathogenesis of APAE since a blockade of this receptor subtype attenuated the cardiopulmonary deterioration and improved blood gas exchanges in rats with this disease...
  37. ncbi Effect of castration on endothelin receptors
    Robert J Padley
    Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, U S A
    Clin Sci (Lond) 103:442S-445S. 2002
    ....
  38. ncbi Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum
    A M Sullivan
    Department of Pharmacology, University of Cambridge, England
    J Neurochem 67:1409-18. 1996
    ..It appears likely that ETs play an important neuromodulatory role in the cerebellum...
  39. ncbi Differential inhibition by TAK-044 of the inotropic effects of endothelin-1 and endothelin-3
    Shin Ichi Yomogida
    Department of Cardiovascular Pharmacology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Eur J Pharmacol 492:217-24. 2004
    ....
  40. ncbi Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus
    María S Jaureguiberry
    Catedra de Fisiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Peptides 25:1133-8. 2004
    ..Our results showed that both ET-1 and ET-3 modulate neuronal NOS activity through the ETB receptor in the rat anterior hypothalamus involving the participation of the PLC-PKC/IP3 pathway as well as PKA and CaMK-II...
  41. ncbi The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
    Wataru Takahashi
    Section of Urology, Yale University School of Medicine, New Haven, CT 06520, USA
    Naunyn Schmiedebergs Arch Pharmacol 366:166-76. 2002
    ..These results suggest the existence of a region/lobe-specific regulatory role for testosterone in the expression of the ET receptor system in the rat prostate...
  42. ncbi Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus
    Carolina Morgazo
    Cátedra de Fisiología e Instituto de Química y Metabolismo del Fármaco IQUIMEFA CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Biochem Biophys Res Commun 334:796-802. 2005
    ..Taken jointly present and previous results it can be concluded that both ETs play an important role as modulators of norepinephrine neurotransmission in the rat AHR...
  43. ncbi Endothelin-1 induces CXCL1 and CXCL8 secretion in human melanoma cells
    Catherine R Mangahas
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA
    J Invest Dermatol 125:307-11. 2005
    ..This study demonstrates that ET-1 additionally induces secretion of CXC chemokines critical for melanoma metastasis and tumor progression...
  44. ncbi Transient expression of endothelins in the amoeboid microglial cells in the developing rat brain
    Chun Yun Wu
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Glia 54:513-25. 2006
    ..The present novel finding has added microglia as a new cellular source of ET that may take part in multiple functions including regulating vascular constriction and chemokines release...
  45. ncbi A direct effect of aldosterone on endothelin-1 gene expression in vivo
    Stephen Wong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 148:1511-7. 2007
    ..5-fold after 1 h in the kidney and colon, respectively. These results suggest that ET-1 is a direct aldosterone gene target in the kidney and colon and may play an important role in aldosterone-regulated ion homeostasis...
  46. ncbi Short-term regulation of tyrosine hydroxylase activity and expression by endothelin-1 and endothelin-3 in the rat posterior hypothalamus
    Guadalupe Perfume
    Catedra de Fisiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Regul Pept 142:69-77. 2007
    ..Taken jointly present and previous results support that ET-1 and ET-3 may play a relevant role in the modulation of catecholaminergic neurotransmission in the posterior hypothalamus of the rat...
  47. ncbi Endothelin-2 in ovarian follicle rupture
    Chemyong Ko
    Department of Clinical Sciences, University of Kentucky, Lexington, 40536, USA
    Endocrinology 147:1770-9. 2006
    ..As a target tissue of EDN2 action, we identified a layer of smooth muscle cells in the follicular wall of each follicle. Taken together, our data indicate that EDN2 induces follicular rupture by constricting periovulatory follicles...
  48. ncbi Long-term modulation of tyrosine hydroxylase activity and expression by endothelin-1 and -3 in the rat anterior and posterior hypothalamus
    Guadalupe Perfume
    Catedra de Fisiologia, Instituto de Química y Metabolismo del Fármaco, Consejo Nacional de Investigaciones Cientifica y Técnicas, Buenos Aires, Argentina
    Am J Physiol Regul Integr Comp Physiol 294:R905-14. 2008
    ..Present and previous studies may partially explain the cardiovascular effects produced by ETs when applied to the brain...
  49. pmc Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation
    A Rauh
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 154:13-24. 2008
    ..Choriocarcinoma cells display many of the biochemical and morphological characteristics of in utero invasive trophoblast cells and may therefore be used as a suitable model to study epithelial tumour progression of foetal-derived cells...
  50. ncbi Endothelin 1 versus endothelin 3 in the development of the slow force response to myocardial stretch
    María N Ros
    Residencia de Cardiología, Hospital Italiano de La Plata, La Plata, Argentina
    Can J Cardiol 21:435-8. 2005
    ..The SFR results from an autocrine/paracrine mechanism of angiotensin II and endothelin (ET) release that is triggered by the stretch...
  51. ncbi Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II
    Chii Whei Hu
    Cardiovascular Diseases Research, Novartis Institutes for BioMedical Research, East Hanover, New Jersey 07936 1080, USA
    J Cardiovasc Pharmacol 44:S289-92. 2004
    ..These results suggest that ET-1 and Ang II stimulated aldosterone secretion synergistically in NCIH295R cells and that the effect of ET-1 was mediated via the ETA receptor subtype...
  52. ncbi Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia
    Joanna Rozyczka
    Institute of Anatomy, University of Leipzig, Medical Faculty, Leipzig, Germany
    J Neurosci Res 79:303-9. 2005
    ..We suggest that the observed ET-dependent inhibition of Cx43 expression and the resulting decline of GJIC might represent a major pathway by which ETs regulate astrocytic gene expression in the injured brain...
  53. ncbi Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    Farhad Amiri
    Experimental Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 110:2233-40. 2004
    ..To directly test the role of endothelium-derived ET-1 in cardiovascular pathophysiology, we specifically targeted expression of the human preproET-1 gene to the endothelium by using the Tie-2 promoter in C57BL/6 mice...
  54. ncbi Endothelin ETB receptor signaling in the median eminence and subfornical organ of the rat brain
    Maria del Rosario Garrido
    School of Pharmacy, Laboratory of Neuropeptides, Universidad Central de Venezuela, Apartado Postal 50176, Sabana Grande 1050A, Caracas, Venezuela
    Neuropeptides 38:304-10. 2004
    ..These results support the concept that endothelin could play a role in the regulation of brain functions...
  55. ncbi Endothelin receptors in lower esophageal sphincter circular smooth muscle
    Shih Che Huang
    Department of Internal Medicine, Tzu Chi General Hospital and Tzu Chi University, 707, Section 3, Chung Yang Road, Hualien 970, Taiwan
    Regul Pept 127:27-35. 2005
    ..These results demonstrate that the guinea-pig lower esophageal sphincter possesses ETA receptors mediating relaxation and ETB receptors mediating contraction...
  56. ncbi Age-related changes in the properties of the endothelin receptor system at protein and mRNA levels in the rat vas deferens
    Makoto Yono
    Section of Urology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Recept Signal Transduct Res 24:53-66. 2004
    ..These results demonstrate the presence of age-related changes in the properties of the ET receptor system at both protein and mRNA levels in the rat vas deferens...
  57. ncbi Endothelin upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat
    Marc Sonntag
    University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, Canada
    Metabolism 53:1177-83. 2004
    ..Overall, these data indicate that in the IMCD ET-1 increases AVP V(2) receptor expression and these changes are mediated by the ET(B) receptor...
  58. ncbi Endothelin-B receptor blockade inhibits molecular effectors of melanoma cell progression
    Laura Rosanò
    Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy
    J Cardiovasc Pharmacol 44:S136-9. 2004
    ....
  59. ncbi The effect of endothelin-1, endothelin-2 and endothelin-3 in early cerulein-induced acute pancreatitis in rats
    J W Długosz
    Department of Gastroenterology and Internal Medicine, Medical University of Białystok, Poland
    Rocz Akad Med Bialymst 49:85-92. 2004
    ..To assess the effect of endothelins: ET-1, ET-2 and ET-3 on trypsinogen activation, lipase activity and histological changes in the pancreas in early (4 hrs) cerulein acute pancreatitis (AP) in rats...
  60. pmc Mechanism of endothelin-induced contraction in guinea-pig trachea: comparison with rat aorta
    D W Hay
    Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pa 19406 0939
    Br J Pharmacol 100:383-92. 1990
    ....
  61. pmc Endothelin receptors mediating functional responses in human small arteries and veins
    J Riezebos
    Dept of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, Tooting, London
    Br J Pharmacol 111:609-15. 1994
    ..There is no evidence of contractions mediated by 'classical' ETB receptors in these vessels, but small veins appear to contain a functional non ETA/non ETB receptor with a high affinity for endothelin-3...
  62. pmc Different pressor and bronchoconstrictor properties of human big-endothelin-1, 2 (1-38) and 3 in ketamine/xylazine-anaesthetized guinea-pigs
    J P Gratton
    Department of Pharmacology, Medical School, , , Canada
    Br J Pharmacol 114:720-6. 1995
    ..In contrast, in the pulmonary vasculature is localized in the vicinity of the sites responsible for eicosanoid release, an ECE which converts more readily big-endothelin-1 than big-endothelin-2...
  63. pmc A novel ETA-receptor antagonist, FR 139317, inhibits endothelin-induced contractions of guinea-pig pulmonary arteries, but not trachea
    L O Cardell
    Department of Otorhinolaryngology, , Sweden
    Br J Pharmacol 108:448-52. 1993
    ..This suggests an ETA-receptor in the guinea-pig pulmonary artery and another receptor, probably of ETB-type, in the guinea-pig trachea...
  64. doi Contractile effects of endothelins on isolated ampullar segment of human oviduct in luteal phase of menstrual cycle
    Slobodan M Jankovic
    Pharmacology Department, Medical Faculty, University of Kragujevac, Kragujevac, Serbia
    Pharmacol Res 59:69-73. 2009
    ..The results of our study suggest that in the luteal phase both ET(A) and ET(B) receptors regulate tone, and only ET(A) receptors regulate rhythmic activity of human oviduct's ampullar segment...
  65. pmc Altered microvascular reactivity to endothelin-1, endothelin-3 and NG-nitro-L-arginine methyl ester in streptozotocin-induced diabetes mellitus
    E Lawrence
    Pharmacology Group, Biomedical Sciences Division, King s College, London
    Br J Pharmacol 106:1035-40. 1992
    ..The effect of the nitric oxide synthase inhibitor L-NAME is also suppressed in the diabetics, suggesting that there may be decreased local production of, or response, to nitric oxide...
  66. pmc Endothelin-1 and endothelin-3 regulate differently vasoconstrictor responses of smooth muscle of the porcine coronary artery
    M Ushio Fukai
    Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 114:171-9. 1995
    ....
  67. pmc Endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat
    S A Douglas
    Department of Pharmacology, University of Cambridge
    Br J Pharmacol 104:311-20. 1991
    ....
  68. ncbi Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan
    Y Tomita
    Department of Dermatology, Nagoya University School of Medicine, Japan
    Pigment Cell Res 13:130-4. 2000
    ..The disease gene and its chromosomal localization have not been identified yet. Our trial of linkage analysis and positional cloning to determine the disease gene is presented...
  69. ncbi Immunoreactivity of endothelins and endothelin receptor in the stria vascularis of the mouse cochlea
    T Fujimura
    Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Hear Res 128:135-46. 1999
    ..In addition, the role of lysosomes in the crinophagy of the endothelins in the strial intermediate cells is proposed in the +/+ mice...
  70. pmc Evidence for multiple endothelin receptors in the guinea-pig pulmonary artery and trachea
    L O Cardell
    Department of Otorhinolaryngology, , Sweden
    Br J Pharmacol 105:376-80. 1992
    1. The responses of the three peptides, endothelin 1 (ET-1), endothelin 2 (ET-2) and endothelin 3 (ET-3) were analysed on isolated circular segments of pulmonary arteries and trachea from the guinea-pig. 2...
  71. pmc Coeliac haemodynamic effects of endothelin-1, endothelin-3, proendothelin-1 [1-38] and proendothelin-3 [1-41] in conscious rats
    S M Gardiner
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 106:483-8. 1992
    ....
  72. pmc Endothelin receptors mediating contraction in goat cerebral arteries
    J B Salom
    , Hospital Universitario La Fe, Spain
    Br J Pharmacol 109:826-30. 1993
    ..The different antagonistic potency of BQ-123 against endothelin-I and sarafotoxin S6b suggests the existence of subtypes of ETA receptors...
  73. ncbi Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein
    C L Guimaraes
    Department of Pharmacology, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Hypertension 19:II79-86. 1992
    ..Their action appears to rely largely on Ca2+ influx from the external medium (only in part via L- and T-type Ca2+ channels) and activation of protein kinase C but not on eicosanoid generation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. ncbi Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats
    G T Cicila
    Cosmopolitan International Diabetes Center, University of Missouri, Columbia 65212
    J Hypertens 12:643-51. 1994
    ..To determine whether the endothelin-1 or endothelin-3 genes are genetically linked with blood pressure and relative heart weight in segregating rat populations, in the context of an elevated dietary sodium chloride intake...
  75. ncbi Expression of endothelin peptides and mRNA in the human heart
    C Plumpton
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, U K
    Clin Sci (Lond) 90:37-46. 1996
    ..If released from the endothelial cells in vivo, this potent cardiotonic peptide may play an important paracrine role in human cardiovascular function...
  76. ncbi Activation of endogenous thromboxane A2 biosynthesis mediates presynaptic inhibition by endothelin-3 of dog stellate ganglionic transmission
    K Kushiku
    Department of Pharmacology, School of Medicine, Fukuoka University, Japan
    J Pharmacol Exp Ther 272:70-6. 1995
    ....
  77. pmc Characterization of endothelin receptors in the human umbilical artery and vein
    G Bogoni
    Institute of Pharmacology, University of Ferrara, Italy
    Br J Pharmacol 119:1600-4. 1996
    ....
  78. ncbi Evidence of genetic underexpression in chorionic villi samples of euploid fetuses with increased nuchal translucency at 10-11 weeks' gestation
    Antonio Farina
    Prenatal Medicine Unit, Embryology and Applied Biology, University of Bologna, Italy
    Prenat Diagn 26:128-33. 2006
    ..To retrospectively investigate whether the genetic profile from chorionic villous sampling (CVS) found in euploid fetuses with increased NT differs from matched controls...
  79. ncbi A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease
    W J Pavan
    Laboratory for Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 6:1-7. 1995
    ..Only Edn3 and Gnas did not recombine with the ls mutation. Mutational analysis of the Edn3 and Gnas genes will determine whether either gene is responsible for the neural crest deficiencies observed in ls/ls mice...
  80. pmc Different pharmacological profiles of big-endothelin-3 and big-endothelin-1 in vivo and in vitro
    P D'Orléans-Juste
    Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada
    Br J Pharmacol 104:440-4. 1991
    ..The ECE is present in the guinea-pig pulmonary vasculature. Furthermore, our results suggest that the ECE activity is specific for big-ET-1 and may not convert big-ET-3 to its active metabolite, ET-3...
  81. ncbi A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene
    Yoshibumi Matsushima
    Saitama Cancer Center, Research Institute 818 Komuro, Ina, Saitama 362 0806, Japan
    Mamm Genome 13:30-5. 2002
    ..To date, three genes responsible for WS4 have been cloned: genes for a transcription factor SOX10, endothelin 3 (EDN3), and endothelin B receptor (EDNRB)...
  82. ncbi Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain
    Haruo Shinohara
    Department of Anatomy, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Biol Chem 279:41141-8. 2004
    ..These findings indicate that Gi2 mediates signaling from receptors such as the endothelin-B receptor to maintain mitogenic activity in the neural progenitor cells of developing brain...
  83. ncbi Contribution of endogenous endothelin to the extension of myocardial infarct size in rats
    T Watanabe
    Biology Research Laboratories, Takeda Chemical Industries, Ltd, Osaka, Japan
    Circ Res 69:370-7. 1991
    ..endothelin 1 (AwETN40) suppressed changes induced by endothelin 1 and endothelin 2 but did not modify those by endothelin 3 in vivo or in vitro. Effects of AwETN40 on myocardial infarct size were investigated...
  84. ncbi Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model
    E M Southard-Smith
    Mouse Embryology Section, Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
    Nat Genet 18:60-4. 1998
    ..These include mice with deficiencies of endothelin B receptor (Ednrb(s-l); refs 1,2) endothelin 3 (Edn3(ls): refs 1,3) the tyrosine kinase receptor cRet and glial-derived neurotrophic factor...
  85. ncbi Novel nonsense mutation of the endothelin-B receptor gene in a family with Waardenburg-Hirschsprung disease
    P Syrris
    Medical Genetics Unit, St George s Hospital Medical School, London, United Kingdom
    Am J Med Genet 87:69-71. 1999
    ....
  86. ncbi A genistein-sensitive Na+/Ca2+ exchange is responsible for the resting [Ca2+]i and most of the Ca2+ plasma membrane fluxes in stimulated rat cerebellar type 1 astrocytes
    H Rojas
    Laboratorio de Permeabilidad Ionica, Centro de Biofisica y Bioquimica, IVIC Apartado 21827, Caracas 1020 A, Venezuela
    Jpn J Physiol 54:249-62. 2004
    ....
  87. ncbi Endothelin mediates local and systemic disease sequelae in severe experimental pancreatitis
    T Foitzik
    Department of Surgery, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    Pancreas 22:248-54. 2001
    ..These observations underscore the role of endothelin as a mediator of disease severity in AP and suggest that endothelin receptor blockade may become a promising therapeutic tool in this disease...
  88. ncbi Endothelin-1-induced vasodilatation in rat breast tumor is mediated through endothelin-B receptors
    Anil Gulati
    Department of Biopharmaceutical Sciences, The University of Illinois at Chicago, IL 60612, USA
    J Cardiovasc Pharmacol 44:S483-6. 2004
    ..The increase in perfusion was attenuated (-25.2%; P < 0.05) with the administration of BQ788. Results indicate that ET-1 induced an increase in blood flow to tumors in tumor-bearing rats, which is mediated by endothelin-B receptors...
  89. ncbi Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats
    Morag J Young
    P O Box 5152, Clayton 3168, Victoria, Australia
    Endocrinology 151:2622-8. 2010
    ..increased by DOC and CORT/CBX; in contrast, DOC had no effect on mRNA levels for channel inducing factor or endothelin 3, which were elevated only by CORT/CBX. All changes noted were reversed by eplerenone...
  90. ncbi Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle
    G O'Reilly
    Department of Obstetrics and Gynaecology, University of Cambridge Clinical School, United Kingdom
    J Clin Endocrinol Metab 75:1545-9. 1992
    ....
  91. ncbi ETB-type receptors mediate endothelin-stimulated contraction in the aortic vascular smooth muscle of the spiny dogfish shark, Squalus acanthias
    D H Evans
    Mt Desert Island Biological Laboratory, Salsbury Cove, ME 04672, USA
    J Comp Physiol B 165:659-64. 1996
    ..Our data are consistent with the hypothesis that the receptor involved in the contractile response to endothelin of shark aortic vascular smooth muscle is of the ETB-rather than the ETA-type...
  92. ncbi Human homology and candidate genes for the Dominant megacolon locus, a mouse model of Hirschsprung disease
    V Pingault
    INSERM U91, Hopital Henri Mondor, Creteil, France
    Genomics 39:86-9. 1997
    ..have been identified: the RET proto-oncogene, the gene coding for the endothelin B receptor (EDNRB), and the endothelin 3 gene (EDN3)...
  93. ncbi Cloning and characterization of an endothelin-3 specific receptor (ETC receptor) from Xenopus laevis dermal melanophores
    S Karne
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06510
    J Biol Chem 268:19126-33. 1993
    ..Competition binding experiments performed on HeLa cells transiently expressing pETc show that the apparent Ki values for ET-3 and ET-1 to displace [125I]ET-3 are 45.5 +/- 16 and 114 +/- 22 nM, respectively...
  94. ncbi Interstitial deletion of the endothelin-B receptor gene in the spotting lethal (sl) rat
    I Ceccherini
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Hum Mol Genet 4:2089-96. 1995
    ..The discovery of the molecular defect underlying the sl rat phenotype should contribute to the understanding of the genetic heterogeneity of HSCR in man...
  95. pmc Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor
    H Y Lin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    Proc Natl Acad Sci U S A 88:3185-9. 1991
    ..The affinity of the cloned endothelin receptor for endothelin 3 is greater than 100 times less in A10 cells and in a CHO cell line stably transformed by the endothelin ..
  96. ncbi A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)
    R M Hofstra
    Department of Medical Genetics, University of Groningen, The Netherlands
    Nat Genet 12:445-7. 1996
    ..which has pigment abnormalities, but also colonic aganglionosis, carries a mutation in the gene coding for endothelin 3 (Edn3), the ligand for the receptor protein encoded by EDNRB...
  97. ncbi Localization of immunoreactive endothelin and proendothelin in the human lung
    S J Marciniak
    Clinical Pharmacology Unit, University of Cambridge, UK
    Pulm Pharmacol 5:175-82. 1992
    ..If immunoreactive endothelin is released onto these sites in vivo, endothelin may act as a paracrine mediator in the human lung...
  98. ncbi Endothelin-3-converting enzyme activity of the KEL1 and KEL6 phenotypes of the Kell blood group system
    Quan Sha
    Lindsley F Kimball Research Institute of the New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    J Biol Chem 281:7180-2. 2006
    ....
  99. ncbi Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium
    I T Cameron
    Department of Obstetrics and Gynaecology, University of Cambridge Clinical School, UK
    J Reprod Fertil 98:251-5. 1993
    ..These data provide evidence that the three endothelin isoforms are present in human endometrium, and suggest that these potent vasoactive agents may play a role in the paracrine control of the uterine vascular bed...
  100. ncbi Endothelin activation of an inwardly rectifying K+ current in atrial cells
    D Kim
    Department of Physiology and Biophysics, Chicago Medical School, Ill 60064
    Circ Res 69:250-5. 1991
    ..These results indicate that endothelin has a potent negatively chronotropic effect by activation of the inwardly rectifying, muscarinic K+ channel and therefore could be an important regulator of heart function...
  101. ncbi Culture of human intestinal epithelial cell using the dissociating enzyme thermolysin and endothelin-3
    Z Liu
    Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, China
    Braz J Med Biol Res 43:451-9. 2010
    ..This is relatively simple, requiring no sophisticated techniques or instruments, and may have a number of varied applications...

Research Grants66

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
  2. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
    ..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
  3. Gdnf and endothelin-3 regulate colorectal enteric nervous system development
    Allan M Goldstein; Fiscal Year: 2010
    ..The goal of this proposal is to understand the mechanisms that control development of the intestinal nervous system in order to improve our ability to diagnose and treat children born with these chronic and disabling conditions. ..
  4. Gdnf and endothelin-3 regulate colorectal enteric nervous system development
    ALLAN GOLDSTEIN; Fiscal Year: 2009
    ..The goal of this proposal is to understand the mechanisms that control development of the intestinal nervous system in order to improve our ability to diagnose and treat children born with these chronic and disabling conditions. ..
  5. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2010
    ..The proposed studies may lead to potential use of these cells in regenerative therapy and establish a novel model to study the etiology of neural crest cells related human diseases. ..
  6. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2009
    ..The proposed studies may lead to potential use of these cells in regenerative therapy and establish a novel model to study the etiology of neural crest cells related human diseases. ..
  7. ABNORMAL TERMINAL COLON OF THE 1S/1S MUTANT MOUSE
    TAUBE ROTHMAN; Fiscal Year: 2000
    ..They propose this occurs because EDNRBs and EDN3 expression occurs only in the colon and not the small intestine. Therefore, they will compare the expression of EDN3 and EDNRB in the colon and small intestine to see if this is correct. ..
  8. ABNORMAL TERMINAL COLON OF THE 1S/1S MUTANT MOUSE
    TAUBE ROTHMAN; Fiscal Year: 1999
    ..They propose this occurs because EDNRBs and EDN3 expression occurs only in the colon and not the small intestine. Therefore, they will compare the expression of EDN3 and EDNRB in the colon and small intestine to see if this is correct. ..
  9. CORE--TRANSGENIC AND CHIMERIC MOUSE FACILITY
    Nancy Cooke; Fiscal Year: 2002
    ..The generation of mouse models facilitates collaborations and interactions among the Center members as well. ..
  10. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2007
    ..The long-term objective of this study is to understand the molecular genetic basis of HSCR. More generally, our aim is to develop a paradigm for sequence-based biology in complex, human diseases. [unreadable] [unreadable]..
  11. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2000
    ..More generally, the aim is to develop a paradigm for the genetic and molecular analysis of complex, multifactorial human diseases. ..
  12. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2001
    ..More generally, the aim is to develop a paradigm for the genetic and molecular analysis of complex, multifactorial human diseases. ..
  13. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 1999
    ..More generally, the aim is to develop a paradigm for the genetic and molecular analysis of complex, multifactorial human diseases. ..
  14. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2006
    ..The long-term objective of this study is to understand the molecular genetic basis of HSCR. More generally, our aim is to develop a paradigm for sequence-based biology in complex, human diseases. [unreadable] [unreadable]..
  15. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2004
    ..The long-term objective of this study is to understand the molecular genetic basis of HSCR. More generally, our aim is to develop a paradigm for sequence-based biology in complex, human diseases. ..
  16. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2005
    ..The long-term objective of this study is to understand the molecular genetic basis of HSCR. More generally, our aim is to develop a paradigm for sequence-based biology in complex, human diseases. ..
  17. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2000
    ..More generally, the aim is to develop a paradigm for the genetic and molecular analysis of complex, multifactorial human diseases. ..
  18. ROLE OF ENDOTHELIUM IN GLOMERULAR DYSFUNCTION
    Valentina Kon; Fiscal Year: 1990
    ..4) Assessment of endothelin in plasma and other physiologic fluids in conditions having injured endothelial cells. 5) Characterization of glomerular endothelin receptors in injured kidneys...
  19. KELL BLOOD GROUP SYSTEM
    COLVIN REDMAN; Fiscal Year: 2004
    ..3. To determine the mechanisms by which antibodies to Kell suppress erythropoiesis, with emphasis on the interactions of Kell antibodies with nascent Kell antigens that occur on erythroid progenitor cells. ..
  20. PATHOGENESIS OF HEPATIC FIBROSIS AND PORTAL HYPERTENSION
    Don Rockey; Fiscal Year: 1999
    ..These studies have direct relevance to human liver disease and are likely to lead to new approaches for the treatment of portal hypertension, hepatic fibrosis and possibly other forms of fibrosing injury. ..
  21. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  22. ENDOTHELIN IN HIGH-RISK PREGNANCIES
    BARRY WILKES; Fiscal Year: 1991
    ..These experiments will provide important new information on the production and actions of endothelin in human pregnancy and provide insights critical to our understanding of the pathogenesis of vasoconstriction in high-risk pregnancies...
  23. Functions of Kell and XK Blood Group Proteins
    Soohee Lee; Fiscal Year: 2007
    ..We anticipate that findings from our proposed studies will shed important insights into the functions of two important but poorly understood red cell membrane proteins. ..
  24. Functions of Kell and XK Blood Group Proteins
    Soohee Lee; Fiscal Year: 2005
    ..We anticipate that findings from our proposed studies will shed important insights into the functions of two important but poorly understood red cell membrane proteins. ..
  25. Functions of Kell and XK Blood Group Proteins
    Soohee Lee; Fiscal Year: 2006
    ..We anticipate that findings from our proposed studies will shed important insights into the functions of two important but poorly understood red cell membrane proteins. ..
  26. Functions of Kell and XK Blood Group Proteins
    Soohee Lee; Fiscal Year: 2004
    ..We anticipate that findings from our proposed studies will shed important insights into the functions of two important but poorly understood red cell membrane proteins. ..
  27. EXPERIMENTAL TRANSFORMATION OF HUMAN MELANOCYTES IN VIVO
    Meenhard Herlyn; Fiscal Year: 2007
    ..Our unique model allows a systematic dissection of the biological and molecular events leading to human melanoma formation. ..
  28. EXPERIMENTAL TRANSFORMATION OF HUMAN MELANOCYTES IN VIVO
    Meenhard Herlyn; Fiscal Year: 2006
    ..Our unique model allows a systematic dissection of the biological and molecular events leading to human melanoma formation. ..
  29. EXPERIMENTAL TRANSFORMATION OF HUMAN MELANOCYTES IN VIVO
    Meenhard Herlyn; Fiscal Year: 2004
    ..Our unique model allows a systematic dissection of the biological and molecular events leading to human melanoma formation. ..
  30. EXPERIMENTAL TRANSFORMATION OF HUMAN MELANOCYTES IN VIVO
    Meenhard Herlyn; Fiscal Year: 2005
    ..Our unique model allows a systematic dissection of the biological and molecular events leading to human melanoma formation. ..
  31. Generation of an UV-dependent Mouse Model of Melanoma
    Lidia Kos; Fiscal Year: 2009
    ..receptor b (Ednrb) is considered a melanoma progression marker, and in vitro data suggest that its ligand, Endothelin 3 (Edn3), can alter the expression of adhesion molecules in melanoma cells...
  32. Generation of an UV-dependent Mouse Model of Melanoma
    Lidia Kos; Fiscal Year: 2010
    ..receptor b (Ednrb) is considered a melanoma progression marker, and in vitro data suggest that its ligand, Endothelin 3 (Edn3), can alter the expression of adhesion molecules in melanoma cells...
  33. INTERCELLULAR SIGNALS AND INTESTINAL AGANGLIONOSIS
    Raj Kapur; Fiscal Year: 1999
    ..Mice which lack endogenous endothelin 3 (et3), a ligand for ET-B, are also aganglionic, but can be rescued by transgenic techniques which target ..
  34. INTERCELLULAR SIGNALS AND INTESTINAL AGANGLIONOSIS
    Raj Kapur; Fiscal Year: 2000
    ..Mice which lack endogenous endothelin 3 (et3), a ligand for ET-B, are also aganglionic, but can be rescued by transgenic techniques which target ..
  35. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2008
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  36. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2009
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  37. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2009
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  38. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
  39. Cytokines in Sickle Cell Volume Regulation
    Alicia Rivera; Fiscal Year: 2006
    ..abstract_text> ..
  40. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. ..
  41. THE SYMPATHETIC NERVOUS SYSTEM AND PROSTATIC HYPERPLASIA
    Paul Walden; Fiscal Year: 1999
    ..The second system is the spontaneously hypertensive rat, an animal model that displays elevated sympathetic activity with concomitant prostatic hyperplasia. ..
  42. Cellular Quiescence and Brain Tumor Stem Cells
    Cho Lea Tso; Fiscal Year: 2009
    ....
  43. Neural Control of Sodium Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2009
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  44. THE SYMPATHETIC NERVOUS SYSTEM AND PROSTATIC HYPERPLASIA
    Paul Walden; Fiscal Year: 2000
    ..The second system is the spontaneously hypertensive rat, an animal model that displays elevated sympathetic activity with concomitant prostatic hyperplasia. ..
  45. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2009
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. ..
  46. Nociception in Diabetic Neuropathy: Role of Endothelins
    Liliana Berti Mattera; Fiscal Year: 2004
    ..abstract_text> ..
  47. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2006
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. [unreadable] [unreadable] [unreadable]..
  48. THE SYMPATHETIC NERVOUS SYSTEM AND PROSTATIC HYPERPLASIA
    Paul Walden; Fiscal Year: 2002
    ..The second system is the spontaneously hypertensive rat, an animal model that displays elevated sympathetic activity with concomitant prostatic hyperplasia. ..
  49. Neural Control of Na Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2006
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  50. THE SYMPATHETIC NERVOUS SYSTEM AND PROSTATIC HYPERPLASIA
    Paul Walden; Fiscal Year: 2001
    ..The second system is the spontaneously hypertensive rat, an animal model that displays elevated sympathetic activity with concomitant prostatic hyperplasia. ..
  51. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2007
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. [unreadable] [unreadable] [unreadable]..
  52. Neural Control of Sodium Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2007
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  53. Neural Control of Sodium Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2008
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  54. Neural Control of Na Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2005
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  55. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2008
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. ..