endothelins

Summary

Summary: 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.

Top Publications

  1. ncbi Endothelins in breast tumour cell invasion
    Matthew J Grimshaw
    Cancer Research UK, Breast Cancer Biology Group, Guy s Hospital, 3rd Floor, Thomas Guy House, London SE1 9RT, UK
    Cancer Lett 222:129-38. 2005
  2. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
  3. ncbi Cardiovascular endothelins: essential regulators of cardiovascular homeostasis
    Friedrich Brunner
    Department of Pharmacology and Toxicology, University of Graz, Universitatsplatz 2, 8010 Graz, Austria
    Pharmacol Ther 111:508-31. 2006
  4. ncbi The endothelin axis: emerging role in cancer
    Joel Nelson
    University of Pittsburgh School of Medicine, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
    Nat Rev Cancer 3:110-6. 2003
  5. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
  6. ncbi Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brains
    Yutaka Koyama
    Laboratory of Pharmacology, Osaka Ohtani University, Osaka, Japan
    J Pharmacol Sci 118:401-7. 2012
  7. pmc Endothelin
    Yoshifumi Kawanabe
    Department of Neurosurgery, Otsu Municipal Hospital, Shiga, Japan
    Cell Mol Life Sci 68:195-203. 2011
  8. ncbi Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction
    J P Granger
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, USA
    Hypertension 38:718-22. 2001
  9. ncbi Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases
    David Abraham
    Centre for Rheumatology and Connective Tissue Diseases, Department of Medicine, Royal Free and University College Medical School, London, UK
    Curr Vasc Pharmacol 3:369-79. 2005
  10. ncbi Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes
    Yutaka Koyama
    Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Nishikiori Kita 3 11 1, Tonda bayashi, Osaka 584 8540, Japan
    Biochem Biophys Res Commun 371:659-63. 2008

Detail Information

Publications305 found, 100 shown here

  1. ncbi Endothelins in breast tumour cell invasion
    Matthew J Grimshaw
    Cancer Research UK, Breast Cancer Biology Group, Guy s Hospital, 3rd Floor, Thomas Guy House, London SE1 9RT, UK
    Cancer Lett 222:129-38. 2005
    b>Endothelins are a family of small, structurally related, vasoactive peptides that have a great number of physiological roles in many tissues...
  2. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
    ..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
  3. ncbi Cardiovascular endothelins: essential regulators of cardiovascular homeostasis
    Friedrich Brunner
    Department of Pharmacology and Toxicology, University of Graz, Universitatsplatz 2, 8010 Graz, Austria
    Pharmacol Ther 111:508-31. 2006
    ....
  4. ncbi The endothelin axis: emerging role in cancer
    Joel Nelson
    University of Pittsburgh School of Medicine, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
    Nat Rev Cancer 3:110-6. 2003
    Collectively, the endothelins and their receptors--referred to as the endothelin (ET) axis--have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell ..
  5. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
    ..These findings establish a previously unknown mechanism of axonal pathfinding involving vascular-derived endothelins, and have broad implications for endothelins as general mediators of axonal growth and guidance in the ..
  6. ncbi Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brains
    Yutaka Koyama
    Laboratory of Pharmacology, Osaka Ohtani University, Osaka, Japan
    J Pharmacol Sci 118:401-7. 2012
    The receptors for endothelins (ETs) are classified into the ET(A) and ET(B) types. ET(B) receptors are highly expressed in astrocytes, but pharmacological usages of this receptor are not clarified...
  7. pmc Endothelin
    Yoshifumi Kawanabe
    Department of Neurosurgery, Otsu Municipal Hospital, Shiga, Japan
    Cell Mol Life Sci 68:195-203. 2011
    ..In this review, we will discuss the basic science of endothelins, endothelin-converting enzymes, and endothelin receptors...
  8. ncbi Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction
    J P Granger
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, USA
    Hypertension 38:718-22. 2001
    ..Results from ongoing basic and clinical studies, however, should provide new and important information regarding the physiological mechanisms responsible for the elevation in arterial pressure in women with preeclampsia...
  9. ncbi Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases
    David Abraham
    Centre for Rheumatology and Connective Tissue Diseases, Department of Medicine, Royal Free and University College Medical School, London, UK
    Curr Vasc Pharmacol 3:369-79. 2005
    ..Recent studies have indicated that endothelins and their receptor expression affects tissue remodeling and repair...
  10. ncbi Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes
    Yutaka Koyama
    Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Nishikiori Kita 3 11 1, Tonda bayashi, Osaka 584 8540, Japan
    Biochem Biophys Res Commun 371:659-63. 2008
    The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes...
  11. ncbi Effects of endothelins on signal transduction and proliferation in human melanocytes
    Y Yada
    Tochigi Research Laboratories, Kao Corporation, Japan
    J Biol Chem 266:18352-7. 1991
    ..2% bovine pituitary extract, resulting in a 4.5-fold increase in cell number for 12 culture days. These findings strongly suggest involvement of ET in the mechanism regulating proliferation and melanization of human melanocytes...
  12. ncbi Endothelins and NADPH oxidases in the cardiovascular system
    Karigowda J Dammanahalli
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Clin Exp Pharmacol Physiol 35:2-6. 2008
    ..2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and ..
  13. ncbi Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes
    G Imokawa
    Tchigi Research Laboratories, Kao Corporation, Japan
    J Biol Chem 267:24675-80. 1992
    ..These studies suggest that ETs produced and secreted by keratinocytes play an essential role in the maintenance of melanocyte proliferation and UV hyperpigmentation in the epidermis...
  14. ncbi Eyeing endothelins: a cellular perspective
    Ganesh Prasanna
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
    Mol Cell Biochem 253:71-88. 2003
    ..In addition to its vascular effects, endothelins and their receptors have been shown to be present in the eye and to have a number of ocular actions that may be ..
  15. ncbi Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebrates
    Shigehiro Kuraku
    Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minami, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 341:315-23. 2010
    ....
  16. ncbi Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
    T Sakurai
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 348:732-5. 1990
    ..b>Endothelins may elicit biological responses by various signal-transduction mechanisms, including the G protein-coupled ..
  17. ncbi Endothelins as local activators of adrenocortical cells
    C Delarue
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, 76821 Mont Saint Aignan, France
    J Mol Endocrinol 32:1-7. 2004
    ..Here, we review the evidence that endothelins (ETs) synthesized within the adrenal cortex may act as autocrine and/or paracrine factors to regulate ..
  18. ncbi Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphism
    Anna Mitchell
    Department of Nephrology and Hypertension, Essen University Hospital, Germany
    Clin Pharmacol Ther 76:396-408. 2004
    ..We studied the influence of this polymorphism on the responses to ETA antagonism in the presence of endothelin 1 (ET-1), norepinephrine (NA), and angiotensin II (ANGII)...
  19. ncbi Effects of endothelins on cardiac and vascular cells: new therapeutic target for the future?
    Attila Mohácsi
    Department of Cardiology, University Medical School of Debrecen, Hungary
    Curr Vasc Pharmacol 2:53-63. 2004
    ..Indeed, ET receptor antagonists may be able to preserve or restore endothelial integrity and may have antiarrhythmic properties; therefore, they are promising tools in cardiovascular medicine...
  20. pmc Endothelins and their receptors in cancer: identification of therapeutic targets
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Pharmacol Res 63:519-24. 2011
    b>Endothelins and their receptors are important in normal physiology, but have been implicated in various pathophysiological conditions...
  21. ncbi Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes
    Y Koyama
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Yamada Oka 1 6 Suita, 565 0871, Japan
    Neuroscience 136:425-33. 2005
    b>Endothelins play a role in the regulation of astrocytic functions in brain pathologies such as hyperplasia and neurotrophic factor production...
  22. ncbi Kv1.1 expression in microglia regulates production and release of proinflammatory cytokines, endothelins and nitric oxide
    C Y Wu
    Department of Histology and Embryology, Kunming Medical College, Kunming, People s Republic of China
    Neuroscience 158:1500-8. 2009
    ..1 antibody suppressed the expression and release of tumor necrosis factor-alpha, interleukin-1beta, endothelins and nitric oxide (NO) in LPS-activated BV-2 cells. It is concluded that Kv1...
  23. ncbi Endothelins and asthma
    R G Goldie
    Department of Pharmacology, University of Western Australia, Perth, Nedlands, Australia
    Life Sci 65:1-15. 1999
    ..Despite this profile, a causal link between ET-1 and asthma has not been definitively established. This review attempts to bring together some of the evidence suggesting the potential mediator roles for ET-1 in this disease...
  24. ncbi Endothelins in health and disease: an overview
    R G Goldie
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Clin Exp Pharmacol Physiol 26:145-8. 1999
    ..2. However, it is also important to realize that the endothelins play an obligatory role in normal cellular proliferation, repair and tissue development. 3...
  25. ncbi Acute effects of endothelins on endogenous adrenomedullin system in the rat heart: Immunocytochemical and autoradiographic studies
    Anna S Belloni
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 13:669-74. 2004
    ..Conversely, endothelins (ETs) exert a cardiac detrimental action, which seems to be mainly mediated by the ETA receptor, whose ..
  26. ncbi Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1
    Felix Bohm
    Department of Cardiology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Atherosclerosis 160:215-22. 2002
    ..In conclusion, administration of big ET-1 results in enhanced vasoconstriction and increased formation of ET-1 in patients with atherosclerosis as compared to healthy controls which may be due to increased activity of ECE...
  27. ncbi Effects of endothelins on hepatic stellate cell synthesis of endothelin-1 during hepatic wound healing
    Rong Shao
    Duke University Liver Center, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Physiol 191:342-50. 2002
    ..We tested the hypothesis that endothelins (ETs) may regulate endothelin-1 production during hepatic wounding, and have investigated potential mechanisms ..
  28. ncbi The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase)
    J Vijayaraghavan
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 265:14150-5. 1990
    b>Endothelins 1-3 are a family of 21-amino acid peptides whose structure consists of two rings formed by intra-chain disulfide bonds and a linear "COOH-terminal tail...
  29. ncbi Endothelins: pathophysiology and treatment implications in chronic heart failure
    John R Teerlink
    Cardiology, 111C, San Francisco VAACE Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Curr Heart Fail Rep 2:191-7. 2005
    ..Further analysis of the data from these trials, as well as other ongoing studies, may provide insight into these disparate findings and guidance for future investigations...
  30. ncbi Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, KY 40292, USA
    Cardiovasc Toxicol 2:253-61. 2002
    ..This study thus suggests that upregulation of the endothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity...
  31. ncbi Expression of endothelins and their receptors in nonmelanoma skin cancers
    Yi Zhang
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada
    J Cutan Med Surg 10:269-76. 2006
    b>Endothelins are paracrine peptides with growth-promoting and vasoactive functions for a variety of cell types...
  32. ncbi Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin
    Janet J Maguire
    Clinical Pharmacology Unit, Level 6 Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Exp Biol Med (Maywood) 231:806-12. 2006
    ..Therefore, this protective prevention of enhanced ET-1 vasoconstriction in ApoE-/- mice by atorvastatin was independent of its lipid-lowering properties...
  33. ncbi An automated high-performance liquid chromatography fluorescence method for the analyses of endothelins in plasma samples
    P Kumarathasan
    Environmental Health Sciences Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
    Anal Biochem 299:37-44. 2001
    ..liquid chromatographic method with fluorescence detection was developed to simultaneously analyze endothelins, a class of vasoactive peptides, in plasma samples...
  34. pmc Evidence for ETA and ETB receptors in rat skin and an investigation of their function in the cutaneous microvasculature
    E Lawrence
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 115:840-4. 1995
    1. The relative contribution of ETA and ETB receptors in the response of rat skin to endothelins was investigated by use of the selective ETB agonist IRL-1620 and the selective ETA antagonist BQ-123. 2...
  35. pmc The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes
    A Inoue
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Proc Natl Acad Sci U S A 86:2863-7. 1989
    ..sequences of the three human genes were highly conserved within the regions encoding the 21-residue (mature) endothelins, in spite of the fact that the immediately upstream exon sequences, which encode a part of the propeptides, ..
  36. ncbi Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
    Y Kurihara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 368:703-10. 1994
    ..These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis...
  37. ncbi Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Am J Physiol 270:R1279-86. 1996
    ..Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation...
  38. ncbi Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum
    N Emoto
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    J Biol Chem 270:15262-8. 1995
    b>Endothelins (ET) are a family of potent vasoactive peptides that are produced from biologically inactive intermediates, termed big endothelins, via a proteolytic processing at Trp21-Val/Ile22...
  39. ncbi The endothelin axis in cancer
    Anna Bagnato
    Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Int J Biochem Cell Biol 40:1443-51. 2008
    The endothelin axis, comprising endothelins and their receptors, has recently emerged as relevant player in tumor growth and metastasis by regulating mitogenesis, cell survival, angiogenesis, bone remodeling, stimulation of nociceptor ..
  40. ncbi Endothelins regulate astrocyte gap junctions in rat hippocampal slices
    F Blomstrand
    Neuropharmacologie, INSERM U114, College de France, Paris, France
    Eur J Neurosci 19:1005-15. 2004
    ..In the brain, astrocytes represent a major target for endothelins (Ets), a vasoactive family of peptides...
  41. ncbi Effects of aortic stenosis on renal renin, angiotensin receptor, endothelin and NOS gene expression in rats
    Martin C Kammerl
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Deutschland
    Am J Nephrol 22:84-9. 2002
    ..e. aortic stenosis on renal regulation of major vasoconstrictive (renin, endothelins) and vasodilatory systems (NO) are controversial...
  42. ncbi Expression of endothelins and their receptors in cells from human periodontal tissues
    Daisuke Fujioka
    Department of Periodontology and Endodontology, Hiroshima University Faculty of Dentistry, Minami Ku, Hiroshima, Japan
    J Periodontal Res 38:269-75. 2003
    The present study investigated the presence of ET-1 in gingival crevicular fluid (GCF) from patients with periodontitis, and the expression of endothelins (ETs) and their receptors mRNA in cultured cells from human periodontal tissues.
  43. ncbi Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism
    Bruno Battistini
    Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, 2725 Chemin Ste Foy, Sainte Foy, QC G1V 4G5, Canada
    Can J Physiol Pharmacol 81:555-69. 2003
    Recent research on the endothelins (ETs) and their pathways in acute pulmonary embolism (APE) has led to significant advances in the understanding of this disease...
  44. ncbi The current treatment of pulmonary arterial hypertension: time to redefine success
    Stuart Rich
    Section of Cardiology, University of Chicago, 5841 S Maryland Ave, MC 2016, Chicago, IL 60612, USA
    Chest 130:1198-202. 2006
    ..Future trials need to better characterize how therapies affect the pulmonary vasculature pathologically, biologically, and hemodynamically, and whether survival is actually improved...
  45. ncbi Endothelins in chronic diabetic complications
    Zia Ali Khan
    Department of Pathology, University of Western Ontario, London, ON N6A 5C1, Canada
    Can J Physiol Pharmacol 81:622-34. 2003
    b>Endothelins are widely distributed in the body and perform several vascular and nonvascular functions. Experimental data indicate abnormalities of the endothelin system in several organs affected in chronic diabetic complications...
  46. pmc Identification of a novel role for endothelins within the oviduct
    MyoungKun Jeoung
    Division of Clinical and Reproductive Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 151:2858-67. 2010
    b>Endothelins were first identified as potent vasoactive peptides; however, diversity in the biological function of these hormones is now evident...
  47. ncbi Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
    A G Baynash
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
    Cell 79:1277-85. 1994
    ..These findings indicate that interaction of EDN3 with the endothelin-B receptor is essential in the development of neural crest-derived cell lineages. We postulate that defects in the human EDN3 gene may cause Hirschsprung's disease...
  48. pmc Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1
    Y Kurihara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Clin Invest 96:293-300. 1995
    ..Thus, ET-1 is involved in the normal development of the heart and great vessels, and circulating ET-1 and/or other ET isoforms may cause a functional redundancy, at least partly, through the ETA receptor...
  49. ncbi The crystal structure of human endothelin
    R W Janes
    Department of Crystallography, Birkbeck College, University of London, UK
    Nat Struct Biol 1:311-9. 1994
    ..This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity...
  50. pmc Pathophysiology of hypertension in response to placental ischemia during pregnancy: a central role for endothelin?
    Babbette D LaMarca
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Gend Med 5:S133-8. 2008
    ..The initiating event in preeclampsia has been postulated to involve reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium...
  51. ncbi Role of endothelins in hypertension
    Carlos Feldstein
    Hypertension Program, Hospital de Clinicas Jose de San Martin, Buenos Aires University School of Medicine, Argentina
    Am J Ther 14:147-53. 2007
    There are three peptides of endothelial origin, called endothelins (ETs), having different receptors that mediate a potent vasoconstrictor effect and also a mild vasodilation...
  52. ncbi The paracrine endothelin system: pathophysiology and implications in clinical medicine
    B Hocher
    Department of Nephrology, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Germany
    Eur J Clin Chem Clin Biochem 35:175-89. 1997
    Apart from the initially described vasoconstriction, endothelins have been shown to cause a variety of biological activities in non-vascular tissues...
  53. ncbi Endothelin in the central control of cardiovascular and respiratory functions
    T Kuwaki
    Department of Physiology, School of Medicine, Chiba University, Japan
    Clin Exp Pharmacol Physiol 26:989-94. 1999
    ..6. We conclude that endogenous ET-1 plays an important role in the central neural control of circulation and respiration and that ETA receptors mediate this mechanism...
  54. ncbi Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women
    K R Kublickiene
    Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden
    Am J Hypertens 7:50S-55S. 1994
    ..Pretreatment with isradipine at high concentrations attenuates the ET-1 contraction...
  55. ncbi Endothelins and hypoxia-inducible factor in cancer
    M J Grimshaw
    Breast Cancer Biology Group, King s College London School of Medicine, Guy s Hospital, 3rd Floor, Thomas Guy House, London SE1 9RT, UK
    Endocr Relat Cancer 14:233-44. 2007
    ..b>Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis...
  56. ncbi Role of prostanoids and endothelins in the prevention of cyclosporine-induced nephrotoxicity
    I E Darlametsos
    Centre Franco Hellénique de Recherches Biomédicales, Nikolaos Papanikolaou, Corporation of the Municipality Agrinion, Agrinion, 30100, Greece
    Prostaglandins Leukot Essent Fatty Acids 64:231-9. 2001
    ..agents have been found to be implicated in cyclosporine induced nephrotoxicity, among which prostanoids and endothelins are the most important...
  57. ncbi The endothelin system in septic and endotoxin shock
    M Wanecek
    Department of Anaesthesiology and Intensive Care, Karolinska Hospital, S 171 76, Stockholm, Sweden
    Eur J Pharmacol 407:1-15. 2000
    ..Substances like nitric oxide, prostaglandins and endothelins have potent and important properties, involving not only the circulation as such but also the response to ..
  58. ncbi Expression of endothelins and their receptors in glioblastoma cell lines
    Mayra Paolillo
    Dipartimento di Farmacologia Sperimentale ed Applicata, Universita di Pavia, Viale Taramelli 14, 27100, Pavia, Italy
    J Neurooncol 79:1-7. 2006
    The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic ..
  59. ncbi Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Témoins sur l'Infarctus du Myocarde (ECTIM) Study
    V Nicaud
    INSERM U258, Paris, France
    Am J Hypertens 12:304-10. 1999
    ..This result will have to be confirmed in other studies...
  60. ncbi Cloning and functional expression of human endothelin-converting enzyme cDNA
    K Shimada
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    Biochem Biophys Res Commun 207:807-12. 1995
    ..Both COS-1 cells expressing human ECE and its membrane fraction converted big ET-1 most efficiently among big ETs...
  61. ncbi Endothelins may modulate invasion and proliferation of Ewing's sarcoma and neuroblastoma
    Paul Berry
    Division of Cancer Medicine, Cancer Research U K Clinical Centre, St James s University Hospital, Leeds LS9 7TF, U K
    Clin Sci (Lond) 103:322S-326S. 2002
    ..The ET-3 ligand and ET-B receptor may be associated with migration and metastasis of ES and NBL, whereas ET-1 (acting through the ET-A receptor) may regulate their proliferation...
  62. pmc Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice
    Anna P Piovezan
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, R Ferreira Lima 82, Florianópolis 88015 420, SC, Brazil
    Br J Pharmacol 141:755-63. 2004
    1. The contribution of endogenous endothelins to nociceptive responses elicited by ovalbumin (OVA) in the hind-paw of mice sensitised to this antigen (50 microg OVA+5 mg Al(OH)(3), s.c., 14 days beforehand) was investigated. 2...
  63. ncbi Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells
    Thorsten Hagemann
    Department of Haematology and Oncology, University of Gottingen, Gottingen, Germany
    DNA Cell Biol 24:766-76. 2005
    There is increased staining of endothelins (ET-1, -2, and -3) and receptors (ET-RA and -RB) in invasive breast tumors compared to nonneoplastic tissue, and ETs stimulate MCF-7 cell invasion in vitro...
  64. pmc Endothelin ETA and ETB mRNA and receptors expressed by smooth muscle in the human vasculature: majority of the ETA sub-type
    A P Davenport
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital
    Br J Pharmacol 114:1110-6. 1995
    ....
  65. ncbi Endothelins activate Ca(2+)-gated K(+) channels via endothelin B receptors in CD-1 mouse erythrocytes
    A Rivera
    Department of Laboratory Medicine Bader 7, The Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol 277:C746-54. 1999
    ..Calphostin C inhibited 73% of ET-1-induced Gardos activation and 84% of the ET-1-induced membrane protein kinase C activity. Thus endothelins regulate erythrocyte Gardos channels via ET(B) receptors and a calphostin-sensitive mechanism.
  66. ncbi Structure-activity relationships of endothelin: importance of the C-terminal moiety
    S Kimura
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 156:1182-6. 1988
    ..These results indicate that the C-terminal Trp of ET is especially important for the potent and extremely long-lasting vasoconstrictor activity characteristic to ET...
  67. ncbi Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32]
    C Fernandez-Patron
    Research Center, Maisonneuve-Rosemont Hospital and Department of Medicine, , ,
    FASEB J 15:2230-40. 2001
    ....
  68. ncbi Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle
    Bela Kanyicska
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
    Endocrine 20:53-8. 2003
    ..In this study, we investigated the role of endogenous endothelins in regulating PRL secretion during the estrous cycle...
  69. ncbi Role of endothelins in congestive heart failure
    Gordon W Moe
    St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Can J Physiol Pharmacol 81:588-97. 2003
    ..Large-scale trials that address to hard clinical outcomes are ongoing and their results forthcoming. A key question that remains concerns whether selective ETA or dual ETA-ETB receptor blockade will be more effective...
  70. ncbi Endothelins: a possible mechanism of cytostatics-induced cardiomyopathy
    András Zsáry
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Leuk Lymphoma 45:351-5. 2004
    ....
  71. ncbi Role of endothelins in septic, cardiogenic, and hemorrhagic shock
    S Magder
    McGill University Health Center, McGill University, Divisions of Critical Care and Clinical Biochemistry, Royal Victoria Hospital, 687 Pine Ave W, Montreal, QC H3A 1A1, Canada
    Can J Physiol Pharmacol 81:635-43. 2003
    ..In all forms of shock, the concentrations of endothelins (ETs) are elevated, and they are especially high in septic shock...
  72. ncbi Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase C
    Joice M da Cunha
    Department of Pharmacology, Faculty of Medicine, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Eur J Pharmacol 501:87-94. 2004
    The present study assesses the capacity of endothelins to induce mechanical hypernociception, and characterises the receptors involved and the contribution of cAMP and protein kinases A (PKA) and C (PKC) to this effect...
  73. ncbi Endothelins and nitric oxide: vasoactive modulators of carotid body chemoreception
    Sergio Rey
    Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, P Universidad Católica of Chile, Casilla 114 D, Santiago 1, Chile
    Curr Neurovasc Res 1:465-73. 2004
    ..In this review, we examine recent evidence supporting the idea that endothelins (ETs) and nitric oxide (NO) modulate the CB function acting upon chemoreceptor cells and chemosensory neurons ..
  74. ncbi Endothelins negatively regulate glial glutamate transporter expression
    Joanna Rozyczka
    Institute of Anatomy, University of Leipzig, Medical Faculty, Leipzig, Germany
    Brain Pathol 14:406-14. 2004
    ..We now demonstrate that the stimulatory influences of these injury-regulated growth factors are overridden by endothelins (ETs), a family of peptides also upregulated in the injured brain...
  75. ncbi Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells
    A Nakano
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Japan
    J Immunol 159:1987-92. 1997
    Chymase from human mast cells selectively cleaved big endothelins (ETs) at the Tyr31-Gly32 bond and produced novel trachea-constricting 31-amino acid-length endothelins, ETs(1-31), without any further degradation products...
  76. ncbi The endothelins in the pulmonary system
    R G Goldie
    Department of Pharmacology, University of Western Australia, Perth, Nedlands, Australia
    Pulm Pharmacol 9:69-93. 1996
    ..Additionally, ECE-1 and ECE-2 present as potentially important targets for therapeutic intervention, although the development of selective nonpeptide inhibitors may be some years away...
  77. ncbi Autocrine regulation of prolactin secretion by endothelins: a permissive role for estradiol
    B Kanyicska
    Program in Neuroscience, Department of Biological Science, Florida State University, Tallahassee 32306 4340, USA
    Endocrine 16:133-7. 2001
    ..Our results also emphasize that endogenous endothelins may play an important role in the negative feedback regulation of PRL secretion in female rats.
  78. ncbi Role of endothelins in animal models of hypertension: focus on cardiovascular protection
    Pierre Moreau
    Laboratory of Vascular Pharmacology, Faculty of Pharmacy, Universite de Montreal, PO Box 6128, Succ Centre Ville, Montreal, QC H3C 3J7, Canada
    Can J Physiol Pharmacol 81:511-21. 2003
    ..Of the different endothelial factors, endothelins, which play an important role in vasodilatation-vasoconstriction balance, have been the subject of great ..
  79. ncbi ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
    D Xu
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
    Cell 78:473-85. 1994
    ..ECE-1 may provide a target for pharmacological intervention to alter ET-1 production...
  80. ncbi Evolution of streptozotocin-pancreatic damage in the rat: modulatory effect of endothelins on the nitridergic and prostanoid pathway
    E Gonzalez
    Centro de Estudios Farmacologicos y Botanicos CEFYBO, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Barcelona, Spain
    Nitric Oxide 3:459-66. 1999
    ..of nitric oxide (NO) and prostaglandins (PGs) is found in the pancreas of streptozotocin-diabetic rats and that endothelins (ETs) are closely related to the nitridergic and prostanoid pathway in several tissues...
  81. ncbi Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinoma
    Meaghan L Douglas
    Southern Clinical Division, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Cancer 100:2118-24. 2004
    ..The endothelin axis has been implicated in cancer growth, angiogenesis, and metastasis, but to the authors' knowledge the expression of endothelin genes has not been defined in renal cell carcinoma (RCC)...
  82. ncbi Endothelins come home to roost
    J Vane
    Nature 348:673. 1990
  83. ncbi Endothelin-1 induces mucosal mast cell degranulation in the rat small intestine
    L Szalay
    Institute of Experimental Surgery, Szent Györgyi Albert Medical University, Szeged, Hungary
    Life Sci 67:1947-58. 2000
    ....
  84. ncbi EDNRB/EDN3 and Hirschsprung disease type II
    A S McCallion
    Johns Hopkins University, McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland 21287, USA
    Pigment Cell Res 14:161-9. 2001
    ..5 days post-coitum. We review the present understanding of pigment cell development in the context of EDNRB/EDN3--a receptor-mediated pathway with pleiotropic effects...
  85. ncbi Endothelins and their receptors as biological markers for oral cancer
    Renata R Hoffmann
    Postgraduate Program of Dental College, PUCRS, Pontificia Universidade Catolica do Rio Grande do Sul, Partenon, Porto Alegre, Brazil
    Oral Oncol 46:644-7. 2010
    ..During the last years, several studies have identified potential biomarkers of OSCC progression and prognosis. Endothelins and their receptors are involved in several pathophysiological conditions and in various cancer types...
  86. ncbi Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult rats
    J J Li
    Department of Histology and Embryology, Faculty of Basic Medical Sciences, Kunming Medical College, Kunming, PR China
    Neuroscience 167:665-77. 2010
    We reported previously that amoeboid microglial cells (AMC) in the developing brain exhibited endothelins (ETs) expression which diminished with advancing age and was undetected in microglia in the more mature brain...
  87. ncbi Changes of hemostasis, endogenous fibrinolysis, platelet activation and endothelins after percutaneous transluminal coronary angioplasty in patients with stable angina
    M Borries
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Dusseldorf, Deutschland
    J Am Coll Cardiol 34:486-93. 1999
    ....
  88. ncbi Hyperhexosemia induced functional and structural changes in the kidneys: role of endothelins
    S Chen
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Nephron 90:86-94. 2002
    ..The present study investigates the role of endothelins (ETs) in the pathogenesis of such changes in diabetic nephropathy.
  89. ncbi Regulation of sinusoidal perfusion: in vivo methodology and control by endothelins
    M G Clemens
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    Semin Liver Dis 19:383-96. 1999
    ..that sinusoids constrict in vivo in a graded and reversible manner in response to specific mediators such as endothelins. This constriction is modulated by dilators such as nitric oxide and carbon monoxide, which are also generated ..
  90. ncbi Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction
    I Hubloue
    Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium
    Eur Respir J 21:19-24. 2003
    ..The authors conclude that endogenous nitric oxide is released by, and opposes the vasoconstricting effects of, endothelins in vivo, reducing systemic blood pressure and limiting hypoxic pulmonary vasoconstriction.
  91. ncbi The role of endothelins and their receptors in heart failure
    D Giannessi
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Pisa, Italy
    Pharmacol Res 43:111-26. 2001
    ....
  92. ncbi Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ET(B) receptor agonist, IRL 1620
    K M Bell
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, UK
    Int J Cancer 80:295-302. 1999
    ..These differences may be exploitable for therapeutic benefit...
  93. ncbi Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension
    Michael Bauer
    Department of Anesthesiology, University of the Saarland, Homburg, Germany
    Circulation 105:1034-6. 2002
    ..Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as to proliferative changes in the pulmonary vascular bed...
  94. ncbi Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats
    D Dunbar Ivy
    Section of Pediatric Cardiology, Pediatric Heart Lung Center, University of Colorado School of Medicine, 1056 E 19th Ave, Denver, CO 80218, USA
    Am J Physiol Lung Cell Mol Physiol 282:L703-12. 2002
    ..These findings suggest that the ET(B) receptor plays a protective role in the pulmonary hypertensive response to chronic hypoxia...
  95. ncbi Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow
    Stephen M Black
    Department of Pediatrics, Northwestern University, Chicago, Ill, USA
    Circulation 108:1646-54. 2003
    ..The objective of this study was to investigate the role of potential later alterations of the ET cascade in the pathophysiology of pulmonary hypertension secondary to increased pulmonary blood flow...
  96. ncbi Altered regulation of endothelin A receptor subtype in the cerebral arterioles in response to a Japanese-style diet, in stroke-prone hypertensive rats
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Hypertens 21:105-13. 2003
    ....
  97. ncbi Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow
    Berna K Oktar
    Department of Physiology, Marmara University School of Medicine, 81326 Haydarpasa, Istanbul, Turkey
    Am J Physiol Gastrointest Liver Physiol 282:G647-55. 2002
    ..Furthermore, ET is involved in the pathogenesis of post-reperfusion-induced damage and beneficial effects of ET receptor antagonism are related to an improvement of disturbed blood flow during the reperfusion period...
  98. pmc Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone
    Graeme A Deuchar
    Department of Medical Cardiology, University of Glasgow, Royal Infirmary, Glasgow G31 2ER
    Br J Pharmacol 135:1060-8. 2002
    ..An increased responsiveness to ET-1 was shown in the pulmonary arterial bed of rabbits with PHT secondary to LVD, implicating a pathophysiological role for ET-1 in this model...
  99. ncbi Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells
    Daohong Chen
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 284:L614-21. 2003
    ..Our data indicate that local production of ET-1 regulates COX-2 by activation of the ET(A) receptor and phosphorylation of p38 and p44/42 MAPK in PLVSMC...
  100. ncbi The expression of angiotensin and endothelin system members in bovine corpus luteum during estrous cycle and pregnancy
    Bajram Berisha
    Institute of Physiology, Technical University of Munich, Weihenstephaner Berg, Freising, Germany
    Endocrine 19:305-12. 2002
    ....
  101. ncbi Functional role of ETB receptors in the renal medulla
    Ivanka Vassileva
    Vascular Biology Center, Department of Surgery, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 41:1359-63. 2003
    ..Taken together, these findings support the hypothesis that endothelin plays an important role in regulating sodium excretion through activation of ETB receptors...

Research Grants69

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
  2. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
  3. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  4. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ....
  5. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ....
  6. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of aldosterone in the progression of cardiovascular and renal disease. ..
  7. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  8. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..Jeff Isenberg's lab). Definition of this pathway will therefore present a novel therapeutic target for the vascular complications of SCD. ..
  9. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    ....
  10. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..
  11. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ....
  12. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..The information gained from this study could be useful in developing endothelin receptor antagonists as neuroprotective agents in glaucoma treatment. ..
  13. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
  14. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..abstract_text> ..
  15. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
    ....
  16. PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..These studies will likely provide new diagnostic bio-markers for assessment of PHT, and novel therapeutic targets for a disease that currently has few or no therapeutic options. ..
  17. Cerebral Malaria: Mechanisms of disease and neurological salvage
    Mahalia S Desruisseaux; Fiscal Year: 2013
    ..Thus, vascular compromise and alterations in Akt and tau may be important in the pathogenesis of malaria and may provide rational targets of drug therapy to ameliorate the consequences of this infection. ..
  18. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2012
    ....
  19. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2012
    ..abstract_text> ..
  20. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2012
    ..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
  21. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..The proposed studies will investigate the role of antenatal betamethasone to restore normal vascular function to the infant's lungs before birth to avoid periods of hypoxemia. ..
  22. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ....
  23. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2013
    ..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
  24. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2012
    ..A better understanding of this mechanisms in PAH will lead to the development of novel therapeutic approaches to prevent and cure this debilitating disease. ..
  25. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ....
  26. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..in vascular endothelium is a key regulator for many of the endothelium-derived vasoactive factors, including endothelins, prostaglandins, nitric oxide, and endothelium- derived hyperpolarizing factor (EDHF)...
  27. Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular react
    Frank W Sellke; Fiscal Year: 2013
    ..The results of these studies may have significant implications regarding the recovery of diabetic and other patients after cardiac surgery involving cardioplegia and CPB. ..
  28. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2013
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to new therapeutic strategies for this increasingly at risk population. ..
  29. Prostacyclin Synthase and Receptors in Pulmonary Arterial Hypertension
    Mark W Geraci; Fiscal Year: 2011
    ....
  30. Novel functions of RGS3
    Nickolai O Dulin; Fiscal Year: 2012
    ..Therefore, defining the molecular mechanisms of T cell activation and differentiation may lead to a better understanding the pathogenesis of these diseases. ..
  31. Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger Transcrip
    David Sherris; Fiscal Year: 2010
    ..Work from this project will further advance our knowledge on zinc finger protein transcription factor/DNA interactions and may thus open the door to a whole new range of therapeutic agents. ..
  32. Hypertension, Kidney and Pregnancy
    Joey P Granger; Fiscal Year: 2013
    ..Based on preliminary data presented in this application, we propose that induction of hemeoxygenase-1 and its catalytic products, carbon monoxide and bilirubin, may provide a novel therapeutic approach for the treatment of PE. ..
  33. The Kidney, Hypertension, Pregnancy and Inflammation
    Babbette LaMarca; Fiscal Year: 2013
    ....
  34. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..The goal of this proposal is to develop new and effective therapies to treat acute traumatic brain injury in children utilizing an immature large animal model. ..
  35. Insulin as a Regulator of Microvascular Exchange
    Virginia H Huxley; Fiscal Year: 2013
    ..abstract_text> ..
  36. Functional characterization of ATP1A1 and DEspR variants associated with essentia
    Nelson Ruiz Opazo; Fiscal Year: 2010
    ....
  37. Role of Endothelin B Receptor in Vascular Protection in Females
    Raouf A Khalil; Fiscal Year: 2011
    ....
  38. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    John C Longhurst; Fiscal Year: 2013
    ..Additional knowledge derived from these studies will allow a better understanding of the mechanisms underlying the genesis of angina pectoris and reflex activation of the cardiovascular system during myocardial ischemia and reperfusion. ..
  39. Effects of insulin on the microvasculature
    EUGENE JOSEPH BARRETT; Fiscal Year: 2013
    ....
  40. Human Aging, Exercise &FMD: Translational Physiology
    Douglas R Seals; Fiscal Year: 2013
    .._OVIDED. University of Colorado-Boulder, Boulder, Colorado ..
  41. CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
    Costantino Iadecola; Fiscal Year: 2013
    ..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
  42. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..To test the hypothesis that Endothelin-1 and ROS facilitate T lymphocyte mediated AT1-AA induced increases blood pressure response to placental ischemia in pregnant rats . ..
  43. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
    ....
  44. Preeclampsia, IUGR and Hypertension: Targets for Treatment
    Joey P Granger; Fiscal Year: 2013
    ....
  45. The Association of Chronic Exposure to Particulate Matter Air Pollutants, Inflamm
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2013
    ..The samples will be analyzed using an automated energy dispersive XRF instrument. . ..
  46. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2013
    ....
  47. Ah Receptor and Endothelin-Dependent Hypertension
    Mary K Walker; Fiscal Year: 2010
    ..Our results will define a novel regulatory pathway for suppression of hypoxia-induced ET- 1, which could be use to develop new therapies for ET-1-dependent cardiovascular diseases. ..
  48. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2012
    ..abstract_text> ..
  49. Internalization of gap junctions as a regulatory mechanism of direct GJIC
    Matthias M Falk; Fiscal Year: 2013
    ....
  50. Rho-kinase signaling in lung development and persistent pulmonary hypertension
    Jason Gien; Fiscal Year: 2013
    ..The strength of this proposal is the assembly of several successful scientists who will assure both progress and success in my research career and guide me towards independence as a physician scientist. ..
  51. Low birth weight, the kidney, and hypertension
    Barbara T Alexander; Fiscal Year: 2013
    ..abstract_text> ..
  52. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..The results should provide new insight into the integrative biological mechanisms by which sex hormone deficiency modulates the age-related reduction in large artery compliance in women as they transition through the menopause. ..
  53. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2012
    ..The results derived from these studies are essential to advance our understanding in the pathogenesis of retinal vascular disease associated with retinal ischemia and may suggest novel targets for future therapeutic interventions...
  54. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ....
  55. Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular Disease
    David J Moser; Fiscal Year: 2012
    ..abstract_text> ..
  56. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..abstract_text> ..
  57. SPORE IN PROSTATE CANCER
    WILLIAM GEORGE NELSON; Fiscal Year: 2013
    ..The Research Projects are supported by an Administrative Core (A), which also manages inter-SPORE collaborations, a Tissue Archive Core (B), and a Biostatistics and Epidemiology Core (C). ..
  58. Evaluation of In Vitro Companion Diagnostic Monoclonal Antibodies for Use in a St
    Christopher Horvath; Fiscal Year: 2013
    ..Combined use of anti-DEspR companion diagnostic and therapeutic mAbs has the potential to alter oncology clinical practice, particularly in BCa/TNBC, as an addition to or advantage over existing treatments. ..
  59. Oxidant signaling for airway remodeling and inflammation
    YUICHIRO JUSTIN SUZUKI; Fiscal Year: 2012
    ..In addition, the results will fundamentally advance the field of lung cell biology. (End of Abstract) ..
  60. BK Virus Receptor and polyomavirus nephropathy
    Andrey Sorokin; Fiscal Year: 2012
    ..b>Endothelins (ET), agonists of G- protein coupled receptors;act as important mediators of renal disease progression...
  61. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..Assessment of these biomarkers to predict risk of dementia prior to cognitive symptoms emerging will increase ability to develop strategies of prevention and early detection. ..
  62. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..The goals are to place Mef2c into a transcriptional pathway and to identify the immediate transcriptional effectors of endothelin signaling in craniofacial development. ..
  63. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ....
  64. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. ..
  65. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
    ..If the data confirm our hypothesis, treatment of IR patients with ET1 antagonists may be a rational and beneficial approach to reducing the dreaded cardiovascular outcomes associated with IR and type 2 diabetes. ..
  66. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2006
    ..The research will be performed primarily at the Brazil site in collaboration with Herbert Tanowitz at the US site as extension of NIH Grant AI-12770 [unreadable] [unreadable]..
  67. Role of NO and Endothelin in Human NEC
    GAIL BESNER; Fiscal Year: 2007
    ..If successful, these data could provide a platform for a prospective, randomized trial of new medical therapeutic strategies for NEC, e.g., the pharmacological manipulation of endothelin receptors. [unreadable] [unreadable]..
  68. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
  69. ABNORMAL TERMINAL COLON OF THE 1S/1S MUTANT MOUSE
    TAUBE ROTHMAN; Fiscal Year: 2000
    ..They propose this occurs because EDNRBs and EDN3 expression occurs only in the colon and not the small intestine. Therefore, they will compare the expression of EDN3 and EDNRB in the colon and small intestine to see if this is correct. ..