Genomes and Genes
Summary: 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Publications305 found, 100 shown here
- Endothelins in breast tumour cell invasionMatthew J Grimshaw
Cancer Research UK, Breast Cancer Biology Group, Guy s Hospital, 3rd Floor, Thomas Guy House, London SE1 9RT, UK
Cancer Lett 222:129-38. 2005b>Endothelins are a family of small, structurally related, vasoactive peptides that have a great number of physiological roles in many tissues...
- A novel potent vasoconstrictor peptide produced by vascular endothelial cellsM Yanagisawa
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Nature 332:411-5. 1988..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
- Cardiovascular endothelins: essential regulators of cardiovascular homeostasisFriedrich Brunner
Department of Pharmacology and Toxicology, University of Graz, Universitatsplatz 2, 8010 Graz, Austria
Pharmacol Ther 111:508-31. 2006....
- The endothelin axis: emerging role in cancerJoel Nelson
University of Pittsburgh School of Medicine, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
Nat Rev Cancer 3:110-6. 2003Collectively, the endothelins and their receptors--referred to as the endothelin (ET) axis--have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell ..
- Endothelins are vascular-derived axonal guidance cues for developing sympathetic neuronsTakako Makita
The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 452:759-63. 2008..These findings establish a previously unknown mechanism of axonal pathfinding involving vascular-derived endothelins, and have broad implications for endothelins as general mediators of axonal growth and guidance in the ..
- Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brainsYutaka Koyama
Laboratory of Pharmacology, Osaka Ohtani University, Osaka, Japan
J Pharmacol Sci 118:401-7. 2012The receptors for endothelins (ETs) are classified into the ET(A) and ET(B) types. ET(B) receptors are highly expressed in astrocytes, but pharmacological usages of this receptor are not clarified...
- EndothelinYoshifumi Kawanabe
Department of Neurosurgery, Otsu Municipal Hospital, Shiga, Japan
Cell Mol Life Sci 68:195-203. 2011..In this review, we will discuss the basic science of endothelins, endothelin-converting enzymes, and endothelin receptors...
- Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunctionJ P Granger
Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, USA
Hypertension 38:718-22. 2001..Results from ongoing basic and clinical studies, however, should provide new and important information regarding the physiological mechanisms responsible for the elevation in arterial pressure in women with preeclampsia...
- Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinasesDavid Abraham
Centre for Rheumatology and Connective Tissue Diseases, Department of Medicine, Royal Free and University College Medical School, London, UK
Curr Vasc Pharmacol 3:369-79. 2005..Recent studies have indicated that endothelins and their receptor expression affects tissue remodeling and repair...
- Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytesYutaka Koyama
Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Nishikiori Kita 3 11 1, Tonda bayashi, Osaka 584 8540, Japan
Biochem Biophys Res Commun 371:659-63. 2008The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes...
- Effects of endothelins on signal transduction and proliferation in human melanocytesY Yada
Tochigi Research Laboratories, Kao Corporation, Japan
J Biol Chem 266:18352-7. 1991..2% bovine pituitary extract, resulting in a 4.5-fold increase in cell number for 12 culture days. These findings strongly suggest involvement of ET in the mechanism regulating proliferation and melanization of human melanocytes...
- Endothelins and NADPH oxidases in the cardiovascular systemKarigowda J Dammanahalli
Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Clin Exp Pharmacol Physiol 35:2-6. 2008..2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and ..
- Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytesG Imokawa
Tchigi Research Laboratories, Kao Corporation, Japan
J Biol Chem 267:24675-80. 1992..These studies suggest that ETs produced and secreted by keratinocytes play an essential role in the maintenance of melanocyte proliferation and UV hyperpigmentation in the epidermis...
- Eyeing endothelins: a cellular perspectiveGanesh Prasanna
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
Mol Cell Biochem 253:71-88. 2003..In addition to its vascular effects, endothelins and their receptors have been shown to be present in the eye and to have a number of ocular actions that may be ..
- Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebratesShigehiro Kuraku
Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minami, Chuo Ku, Kobe 650 0047, Japan
Dev Biol 341:315-23. 2010....
- Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptorT Sakurai
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Nature 348:732-5. 1990..b>Endothelins may elicit biological responses by various signal-transduction mechanisms, including the G protein-coupled ..
- Endothelins as local activators of adrenocortical cellsC Delarue
European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, 76821 Mont Saint Aignan, France
J Mol Endocrinol 32:1-7. 2004..Here, we review the evidence that endothelins (ETs) synthesized within the adrenal cortex may act as autocrine and/or paracrine factors to regulate ..
- Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphismAnna Mitchell
Department of Nephrology and Hypertension, Essen University Hospital, Germany
Clin Pharmacol Ther 76:396-408. 2004..We studied the influence of this polymorphism on the responses to ETA antagonism in the presence of endothelin 1 (ET-1), norepinephrine (NA), and angiotensin II (ANGII)...
- Effects of endothelins on cardiac and vascular cells: new therapeutic target for the future?Attila Mohácsi
Department of Cardiology, University Medical School of Debrecen, Hungary
Curr Vasc Pharmacol 2:53-63. 2004..Indeed, ET receptor antagonists may be able to preserve or restore endothelial integrity and may have antiarrhythmic properties; therefore, they are promising tools in cardiovascular medicine...
- Endothelins and their receptors in cancer: identification of therapeutic targetsRong Wang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Pharmacol Res 63:519-24. 2011b>Endothelins and their receptors are important in normal physiology, but have been implicated in various pathophysiological conditions...
- Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytesY Koyama
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Yamada Oka 1 6 Suita, 565 0871, Japan
Neuroscience 136:425-33. 2005b>Endothelins play a role in the regulation of astrocytic functions in brain pathologies such as hyperplasia and neurotrophic factor production...
- Kv1.1 expression in microglia regulates production and release of proinflammatory cytokines, endothelins and nitric oxideC Y Wu
Department of Histology and Embryology, Kunming Medical College, Kunming, People s Republic of China
Neuroscience 158:1500-8. 2009..1 antibody suppressed the expression and release of tumor necrosis factor-alpha, interleukin-1beta, endothelins and nitric oxide (NO) in LPS-activated BV-2 cells. It is concluded that Kv1...
- Endothelins and asthmaR G Goldie
Department of Pharmacology, University of Western Australia, Perth, Nedlands, Australia
Life Sci 65:1-15. 1999..Despite this profile, a causal link between ET-1 and asthma has not been definitively established. This review attempts to bring together some of the evidence suggesting the potential mediator roles for ET-1 in this disease...
- Endothelins in health and disease: an overviewR G Goldie
Department of Pharmacology, University of Western Australia, Nedlands, Australia
Clin Exp Pharmacol Physiol 26:145-8. 1999..2. However, it is also important to realize that the endothelins play an obligatory role in normal cellular proliferation, repair and tissue development. 3...
- Acute effects of endothelins on endogenous adrenomedullin system in the rat heart: Immunocytochemical and autoradiographic studiesAnna S Belloni
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
Int J Mol Med 13:669-74. 2004..Conversely, endothelins (ETs) exert a cardiac detrimental action, which seems to be mainly mediated by the ETA receptor, whose ..
- Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1Felix Bohm
Department of Cardiology, Karolinska Hospital, S 171 76 Stockholm, Sweden
Atherosclerosis 160:215-22. 2002..In conclusion, administration of big ET-1 results in enhanced vasoconstriction and increased formation of ET-1 in patients with atherosclerosis as compared to healthy controls which may be due to increased activity of ECE...
- Effects of endothelins on hepatic stellate cell synthesis of endothelin-1 during hepatic wound healingRong Shao
Duke University Liver Center, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Cell Physiol 191:342-50. 2002..We tested the hypothesis that endothelins (ETs) may regulate endothelin-1 production during hepatic wounding, and have investigated potential mechanisms ..
- The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase)J Vijayaraghavan
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235
J Biol Chem 265:14150-5. 1990b>Endothelins 1-3 are a family of 21-amino acid peptides whose structure consists of two rings formed by intra-chain disulfide bonds and a linear "COOH-terminal tail...
- Endothelins: pathophysiology and treatment implications in chronic heart failureJohn R Teerlink
Cardiology, 111C, San Francisco VAACE Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Curr Heart Fail Rep 2:191-7. 2005..Further analysis of the data from these trials, as well as other ongoing studies, may provide insight into these disparate findings and guidance for future investigations...
- Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarctionY James Kang
Department of Medicine, University of Louisville School of Medicine, KY 40292, USA
Cardiovasc Toxicol 2:253-61. 2002..This study thus suggests that upregulation of the endothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity...
- Expression of endothelins and their receptors in nonmelanoma skin cancersYi Zhang
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada
J Cutan Med Surg 10:269-76. 2006b>Endothelins are paracrine peptides with growth-promoting and vasoactive functions for a variety of cell types...
- Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatinJanet J Maguire
Clinical Pharmacology Unit, Level 6 Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Exp Biol Med (Maywood) 231:806-12. 2006..Therefore, this protective prevention of enhanced ET-1 vasoconstriction in ApoE-/- mice by atorvastatin was independent of its lipid-lowering properties...
- An automated high-performance liquid chromatography fluorescence method for the analyses of endothelins in plasma samplesP Kumarathasan
Environmental Health Sciences Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
Anal Biochem 299:37-44. 2001..liquid chromatographic method with fluorescence detection was developed to simultaneously analyze endothelins, a class of vasoactive peptides, in plasma samples...
- Evidence for ETA and ETB receptors in rat skin and an investigation of their function in the cutaneous microvasculatureE Lawrence
Biomedical Sciences Division, King s College, London
Br J Pharmacol 115:840-4. 19951. The relative contribution of ETA and ETB receptors in the response of rat skin to endothelins was investigated by use of the selective ETB agonist IRL-1620 and the selective ETA antagonist BQ-123. 2...
- The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genesA Inoue
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Proc Natl Acad Sci U S A 86:2863-7. 1989..sequences of the three human genes were highly conserved within the regions encoding the 21-residue (mature) endothelins, in spite of the fact that the immediately upstream exon sequences, which encode a part of the propeptides, ..
- Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1Y Kurihara
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Nature 368:703-10. 1994..These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis...
- Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1T Kuwaki
Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
Am J Physiol 270:R1279-86. 1996..Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation...
- Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimumN Emoto
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
J Biol Chem 270:15262-8. 1995b>Endothelins (ET) are a family of potent vasoactive peptides that are produced from biologically inactive intermediates, termed big endothelins, via a proteolytic processing at Trp21-Val/Ile22...
- The endothelin axis in cancerAnna Bagnato
Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
Int J Biochem Cell Biol 40:1443-51. 2008The endothelin axis, comprising endothelins and their receptors, has recently emerged as relevant player in tumor growth and metastasis by regulating mitogenesis, cell survival, angiogenesis, bone remodeling, stimulation of nociceptor ..
- Endothelins regulate astrocyte gap junctions in rat hippocampal slicesF Blomstrand
Neuropharmacologie, INSERM U114, College de France, Paris, France
Eur J Neurosci 19:1005-15. 2004..In the brain, astrocytes represent a major target for endothelins (Ets), a vasoactive family of peptides...
- Effects of aortic stenosis on renal renin, angiotensin receptor, endothelin and NOS gene expression in ratsMartin C Kammerl
Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Deutschland
Am J Nephrol 22:84-9. 2002..e. aortic stenosis on renal regulation of major vasoconstrictive (renin, endothelins) and vasodilatory systems (NO) are controversial...
- Expression of endothelins and their receptors in cells from human periodontal tissuesDaisuke Fujioka
Department of Periodontology and Endodontology, Hiroshima University Faculty of Dentistry, Minami Ku, Hiroshima, Japan
J Periodontal Res 38:269-75. 2003The present study investigated the presence of ET-1 in gingival crevicular fluid (GCF) from patients with periodontitis, and the expression of endothelins (ETs) and their receptors mRNA in cultured cells from human periodontal tissues.
- Modulation and roles of the endothelins in the pathophysiology of pulmonary embolismBruno Battistini
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, 2725 Chemin Ste Foy, Sainte Foy, QC G1V 4G5, Canada
Can J Physiol Pharmacol 81:555-69. 2003Recent research on the endothelins (ETs) and their pathways in acute pulmonary embolism (APE) has led to significant advances in the understanding of this disease...
- The current treatment of pulmonary arterial hypertension: time to redefine successStuart Rich
Section of Cardiology, University of Chicago, 5841 S Maryland Ave, MC 2016, Chicago, IL 60612, USA
Chest 130:1198-202. 2006..Future trials need to better characterize how therapies affect the pulmonary vasculature pathologically, biologically, and hemodynamically, and whether survival is actually improved...
- Endothelins in chronic diabetic complicationsZia Ali Khan
Department of Pathology, University of Western Ontario, London, ON N6A 5C1, Canada
Can J Physiol Pharmacol 81:622-34. 2003b>Endothelins are widely distributed in the body and perform several vascular and nonvascular functions. Experimental data indicate abnormalities of the endothelin system in several organs affected in chronic diabetic complications...
- Identification of a novel role for endothelins within the oviductMyoungKun Jeoung
Division of Clinical and Reproductive Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Endocrinology 151:2858-67. 2010b>Endothelins were first identified as potent vasoactive peptides; however, diversity in the biological function of these hormones is now evident...
- Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neuronsA G Baynash
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
Cell 79:1277-85. 1994..These findings indicate that interaction of EDN3 with the endothelin-B receptor is essential in the development of neural crest-derived cell lineages. We postulate that defects in the human EDN3 gene may cause Hirschsprung's disease...
- Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1Y Kurihara
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
J Clin Invest 96:293-300. 1995..Thus, ET-1 is involved in the normal development of the heart and great vessels, and circulating ET-1 and/or other ET isoforms may cause a functional redundancy, at least partly, through the ETA receptor...
- The crystal structure of human endothelinR W Janes
Department of Crystallography, Birkbeck College, University of London, UK
Nat Struct Biol 1:311-9. 1994..This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity...
- Pathophysiology of hypertension in response to placental ischemia during pregnancy: a central role for endothelin?Babbette D LaMarca
Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
Gend Med 5:S133-8. 2008..The initiating event in preeclampsia has been postulated to involve reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium...
- Role of endothelins in hypertensionCarlos Feldstein
Hypertension Program, Hospital de Clinicas Jose de San Martin, Buenos Aires University School of Medicine, Argentina
Am J Ther 14:147-53. 2007There are three peptides of endothelial origin, called endothelins (ETs), having different receptors that mediate a potent vasoconstrictor effect and also a mild vasodilation...
- The paracrine endothelin system: pathophysiology and implications in clinical medicineB Hocher
Department of Nephrology, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Germany
Eur J Clin Chem Clin Biochem 35:175-89. 1997Apart from the initially described vasoconstriction, endothelins have been shown to cause a variety of biological activities in non-vascular tissues...
- Endothelin in the central control of cardiovascular and respiratory functionsT Kuwaki
Department of Physiology, School of Medicine, Chiba University, Japan
Clin Exp Pharmacol Physiol 26:989-94. 1999..6. We conclude that endogenous ET-1 plays an important role in the central neural control of circulation and respiration and that ETA receptors mediate this mechanism...
- Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant womenK R Kublickiene
Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden
Am J Hypertens 7:50S-55S. 1994..Pretreatment with isradipine at high concentrations attenuates the ET-1 contraction...
- Endothelins and hypoxia-inducible factor in cancerM J Grimshaw
Breast Cancer Biology Group, King s College London School of Medicine, Guy s Hospital, 3rd Floor, Thomas Guy House, London SE1 9RT, UK
Endocr Relat Cancer 14:233-44. 2007..b>Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis...
- Role of prostanoids and endothelins in the prevention of cyclosporine-induced nephrotoxicityI E Darlametsos
Centre Franco Hellénique de Recherches Biomédicales, Nikolaos Papanikolaou, Corporation of the Municipality Agrinion, Agrinion, 30100, Greece
Prostaglandins Leukot Essent Fatty Acids 64:231-9. 2001..agents have been found to be implicated in cyclosporine induced nephrotoxicity, among which prostanoids and endothelins are the most important...
- The endothelin system in septic and endotoxin shockM Wanecek
Department of Anaesthesiology and Intensive Care, Karolinska Hospital, S 171 76, Stockholm, Sweden
Eur J Pharmacol 407:1-15. 2000..Substances like nitric oxide, prostaglandins and endothelins have potent and important properties, involving not only the circulation as such but also the response to ..
- Expression of endothelins and their receptors in glioblastoma cell linesMayra Paolillo
Dipartimento di Farmacologia Sperimentale ed Applicata, Universita di Pavia, Viale Taramelli 14, 27100, Pavia, Italy
J Neurooncol 79:1-7. 2006The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic ..
- Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Témoins sur l'Infarctus du Myocarde (ECTIM) StudyV Nicaud
INSERM U258, Paris, France
Am J Hypertens 12:304-10. 1999..This result will have to be confirmed in other studies...
- Cloning and functional expression of human endothelin-converting enzyme cDNAK Shimada
Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
Biochem Biophys Res Commun 207:807-12. 1995..Both COS-1 cells expressing human ECE and its membrane fraction converted big ET-1 most efficiently among big ETs...
- Endothelins may modulate invasion and proliferation of Ewing's sarcoma and neuroblastomaPaul Berry
Division of Cancer Medicine, Cancer Research U K Clinical Centre, St James s University Hospital, Leeds LS9 7TF, U K
Clin Sci (Lond) 103:322S-326S. 2002..The ET-3 ligand and ET-B receptor may be associated with migration and metastasis of ES and NBL, whereas ET-1 (acting through the ET-A receptor) may regulate their proliferation...
- Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised miceAnna P Piovezan
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, R Ferreira Lima 82, Florianópolis 88015 420, SC, Brazil
Br J Pharmacol 141:755-63. 20041. The contribution of endogenous endothelins to nociceptive responses elicited by ovalbumin (OVA) in the hind-paw of mice sensitised to this antigen (50 microg OVA+5 mg Al(OH)(3), s.c., 14 days beforehand) was investigated. 2...
- Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cellsThorsten Hagemann
Department of Haematology and Oncology, University of Gottingen, Gottingen, Germany
DNA Cell Biol 24:766-76. 2005There is increased staining of endothelins (ET-1, -2, and -3) and receptors (ET-RA and -RB) in invasive breast tumors compared to nonneoplastic tissue, and ETs stimulate MCF-7 cell invasion in vitro...
- Endothelin ETA and ETB mRNA and receptors expressed by smooth muscle in the human vasculature: majority of the ETA sub-typeA P Davenport
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital
Br J Pharmacol 114:1110-6. 1995....
- Endothelins activate Ca(2+)-gated K(+) channels via endothelin B receptors in CD-1 mouse erythrocytesA Rivera
Department of Laboratory Medicine Bader 7, The Children s Hospital, Boston, Massachusetts 02115, USA
Am J Physiol 277:C746-54. 1999..Calphostin C inhibited 73% of ET-1-induced Gardos activation and 84% of the ET-1-induced membrane protein kinase C activity. Thus endothelins regulate erythrocyte Gardos channels via ET(B) receptors and a calphostin-sensitive mechanism.
- Structure-activity relationships of endothelin: importance of the C-terminal moietyS Kimura
Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Biochem Biophys Res Commun 156:1182-6. 1988..These results indicate that the C-terminal Trp of ET is especially important for the potent and extremely long-lasting vasoconstrictor activity characteristic to ET...
- Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32]C Fernandez-Patron
Research Center, Maisonneuve-Rosemont Hospital and Department of Medicine, , ,
FASEB J 15:2230-40. 2001....
- Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycleBela Kanyicska
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4340, USA
Endocrine 20:53-8. 2003..In this study, we investigated the role of endogenous endothelins in regulating PRL secretion during the estrous cycle...
- Role of endothelins in congestive heart failureGordon W Moe
St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
Can J Physiol Pharmacol 81:588-97. 2003..Large-scale trials that address to hard clinical outcomes are ongoing and their results forthcoming. A key question that remains concerns whether selective ETA or dual ETA-ETB receptor blockade will be more effective...
- Endothelins: a possible mechanism of cytostatics-induced cardiomyopathyAndrás Zsáry
3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Leuk Lymphoma 45:351-5. 2004....
- Role of endothelins in septic, cardiogenic, and hemorrhagic shockS Magder
McGill University Health Center, McGill University, Divisions of Critical Care and Clinical Biochemistry, Royal Victoria Hospital, 687 Pine Ave W, Montreal, QC H3A 1A1, Canada
Can J Physiol Pharmacol 81:635-43. 2003..In all forms of shock, the concentrations of endothelins (ETs) are elevated, and they are especially high in septic shock...
- Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase CJoice M da Cunha
Department of Pharmacology, Faculty of Medicine, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
Eur J Pharmacol 501:87-94. 2004The present study assesses the capacity of endothelins to induce mechanical hypernociception, and characterises the receptors involved and the contribution of cAMP and protein kinases A (PKA) and C (PKC) to this effect...
- Endothelins and nitric oxide: vasoactive modulators of carotid body chemoreceptionSergio Rey
Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, P Universidad Católica of Chile, Casilla 114 D, Santiago 1, Chile
Curr Neurovasc Res 1:465-73. 2004..In this review, we examine recent evidence supporting the idea that endothelins (ETs) and nitric oxide (NO) modulate the CB function acting upon chemoreceptor cells and chemosensory neurons ..
- Endothelins negatively regulate glial glutamate transporter expressionJoanna Rozyczka
Institute of Anatomy, University of Leipzig, Medical Faculty, Leipzig, Germany
Brain Pathol 14:406-14. 2004..We now demonstrate that the stimulatory influences of these injury-regulated growth factors are overridden by endothelins (ETs), a family of peptides also upregulated in the injured brain...
- Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cellsA Nakano
Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Japan
J Immunol 159:1987-92. 1997Chymase from human mast cells selectively cleaved big endothelins (ETs) at the Tyr31-Gly32 bond and produced novel trachea-constricting 31-amino acid-length endothelins, ETs(1-31), without any further degradation products...
- The endothelins in the pulmonary systemR G Goldie
Department of Pharmacology, University of Western Australia, Perth, Nedlands, Australia
Pulm Pharmacol 9:69-93. 1996..Additionally, ECE-1 and ECE-2 present as potentially important targets for therapeutic intervention, although the development of selective nonpeptide inhibitors may be some years away...
- Autocrine regulation of prolactin secretion by endothelins: a permissive role for estradiolB Kanyicska
Program in Neuroscience, Department of Biological Science, Florida State University, Tallahassee 32306 4340, USA
Endocrine 16:133-7. 2001..Our results also emphasize that endogenous endothelins may play an important role in the negative feedback regulation of PRL secretion in female rats.
- Role of endothelins in animal models of hypertension: focus on cardiovascular protectionPierre Moreau
Laboratory of Vascular Pharmacology, Faculty of Pharmacy, Universite de Montreal, PO Box 6128, Succ Centre Ville, Montreal, QC H3C 3J7, Canada
Can J Physiol Pharmacol 81:511-21. 2003..Of the different endothelial factors, endothelins, which play an important role in vasodilatation-vasoconstriction balance, have been the subject of great ..
- ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1D Xu
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
Cell 78:473-85. 1994..ECE-1 may provide a target for pharmacological intervention to alter ET-1 production...
- Evolution of streptozotocin-pancreatic damage in the rat: modulatory effect of endothelins on the nitridergic and prostanoid pathwayE Gonzalez
Centro de Estudios Farmacologicos y Botanicos CEFYBO, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Barcelona, Spain
Nitric Oxide 3:459-66. 1999..of nitric oxide (NO) and prostaglandins (PGs) is found in the pancreas of streptozotocin-diabetic rats and that endothelins (ETs) are closely related to the nitridergic and prostanoid pathway in several tissues...
- Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinomaMeaghan L Douglas
Southern Clinical Division, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Cancer 100:2118-24. 2004..The endothelin axis has been implicated in cancer growth, angiogenesis, and metastasis, but to the authors' knowledge the expression of endothelin genes has not been defined in renal cell carcinoma (RCC)...
- Endothelins come home to roostJ Vane
Nature 348:673. 1990
- Endothelin-1 induces mucosal mast cell degranulation in the rat small intestineL Szalay
Institute of Experimental Surgery, Szent Györgyi Albert Medical University, Szeged, Hungary
Life Sci 67:1947-58. 2000....
- EDNRB/EDN3 and Hirschsprung disease type IIA S McCallion
Johns Hopkins University, McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland 21287, USA
Pigment Cell Res 14:161-9. 2001..5 days post-coitum. We review the present understanding of pigment cell development in the context of EDNRB/EDN3--a receptor-mediated pathway with pleiotropic effects...
- Endothelins and their receptors as biological markers for oral cancerRenata R Hoffmann
Postgraduate Program of Dental College, PUCRS, Pontificia Universidade Catolica do Rio Grande do Sul, Partenon, Porto Alegre, Brazil
Oral Oncol 46:644-7. 2010..During the last years, several studies have identified potential biomarkers of OSCC progression and prognosis. Endothelins and their receptors are involved in several pathophysiological conditions and in various cancer types...
- Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult ratsJ J Li
Department of Histology and Embryology, Faculty of Basic Medical Sciences, Kunming Medical College, Kunming, PR China
Neuroscience 167:665-77. 2010We reported previously that amoeboid microglial cells (AMC) in the developing brain exhibited endothelins (ETs) expression which diminished with advancing age and was undetected in microglia in the more mature brain...
- Changes of hemostasis, endogenous fibrinolysis, platelet activation and endothelins after percutaneous transluminal coronary angioplasty in patients with stable anginaM Borries
Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Dusseldorf, Deutschland
J Am Coll Cardiol 34:486-93. 1999....
- Hyperhexosemia induced functional and structural changes in the kidneys: role of endothelinsS Chen
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Nephron 90:86-94. 2002..The present study investigates the role of endothelins (ETs) in the pathogenesis of such changes in diabetic nephropathy.
- Regulation of sinusoidal perfusion: in vivo methodology and control by endothelinsM G Clemens
Department of Biology, University of North Carolina at Charlotte 28223, USA
Semin Liver Dis 19:383-96. 1999..that sinusoids constrict in vivo in a graded and reversible manner in response to specific mediators such as endothelins. This constriction is modulated by dilators such as nitric oxide and carbon monoxide, which are also generated ..
- Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstrictionI Hubloue
Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium
Eur Respir J 21:19-24. 2003..The authors conclude that endogenous nitric oxide is released by, and opposes the vasoconstricting effects of, endothelins in vivo, reducing systemic blood pressure and limiting hypoxic pulmonary vasoconstriction.
- The role of endothelins and their receptors in heart failureD Giannessi
Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Pisa, Italy
Pharmacol Res 43:111-26. 2001....
- Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ET(B) receptor agonist, IRL 1620K M Bell
Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, UK
Int J Cancer 80:295-302. 1999..These differences may be exploitable for therapeutic benefit...
- Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertensionMichael Bauer
Department of Anesthesiology, University of the Saarland, Homburg, Germany
Circulation 105:1034-6. 2002..Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as to proliferative changes in the pulmonary vascular bed...
- Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient ratsD Dunbar Ivy
Section of Pediatric Cardiology, Pediatric Heart Lung Center, University of Colorado School of Medicine, 1056 E 19th Ave, Denver, CO 80218, USA
Am J Physiol Lung Cell Mol Physiol 282:L703-12. 2002..These findings suggest that the ET(B) receptor plays a protective role in the pulmonary hypertensive response to chronic hypoxia...
- Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flowStephen M Black
Department of Pediatrics, Northwestern University, Chicago, Ill, USA
Circulation 108:1646-54. 2003..The objective of this study was to investigate the role of potential later alterations of the ET cascade in the pathophysiology of pulmonary hypertension secondary to increased pulmonary blood flow...
- Altered regulation of endothelin A receptor subtype in the cerebral arterioles in response to a Japanese-style diet, in stroke-prone hypertensive ratsGian Paolo Rossi
Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
J Hypertens 21:105-13. 2003....
- Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flowBerna K Oktar
Department of Physiology, Marmara University School of Medicine, 81326 Haydarpasa, Istanbul, Turkey
Am J Physiol Gastrointest Liver Physiol 282:G647-55. 2002..Furthermore, ET is involved in the pathogenesis of post-reperfusion-induced damage and beneficial effects of ET receptor antagonism are related to an improvement of disturbed blood flow during the reperfusion period...
- Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular toneGraeme A Deuchar
Department of Medical Cardiology, University of Glasgow, Royal Infirmary, Glasgow G31 2ER
Br J Pharmacol 135:1060-8. 2002..An increased responsiveness to ET-1 was shown in the pulmonary arterial bed of rabbits with PHT secondary to LVD, implicating a pathophysiological role for ET-1 in this model...
- Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cellsDaohong Chen
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 284:L614-21. 2003..Our data indicate that local production of ET-1 regulates COX-2 by activation of the ET(A) receptor and phosphorylation of p38 and p44/42 MAPK in PLVSMC...
- The expression of angiotensin and endothelin system members in bovine corpus luteum during estrous cycle and pregnancyBajram Berisha
Institute of Physiology, Technical University of Munich, Weihenstephaner Berg, Freising, Germany
Endocrine 19:305-12. 2002....
- Functional role of ETB receptors in the renal medullaIvanka Vassileva
Vascular Biology Center, Department of Surgery, Medical College of Georgia, Augusta, GA 30912 2500, USA
Hypertension 41:1359-63. 2003..Taken together, these findings support the hypothesis that endothelin plays an important role in regulating sodium excretion through activation of ETB receptors...
- Human embryonic stem cell-derived neural crest stem cells and Hirschsprung diseaSean J Morrison; Fiscal Year: 2010..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
- Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground MiJefferey L Burgess; Fiscal Year: 2013..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
- Mechanisms of Endothelin 1-Induced Sickle Cell PathologyAlicia Rivera; Fiscal Year: 2011..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
- Expression of sFlt1 and its function in the glomerular endotheliumChristie P Thomas; Fiscal Year: 2013....
- NEURAL REGULATION OF PANCREATIC FUNCTIONKIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012....
- An Aldosterone-Endothelin Feedback Mechanism on Sodium HomeostasisCharles S Wingo; Fiscal Year: 2012..Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of aldosterone in the progression of cardiovascular and renal disease. ..
- Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary HypertensionC Michael Hart; Fiscal Year: 2013..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
- Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle CellEnrico M Novelli; Fiscal Year: 2013..Jeff Isenberg's lab). Definition of this pathway will therefore present a novel therapeutic target for the vascular complications of SCD. ..
- Complement Activation in Pregnancy and HypertensionJean F Regal; Fiscal Year: 2013....
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2009..We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..
- Fate of Lung Stem Cells During Pulmonary DiseaseSusan M Majka; Fiscal Year: 2012....
- Role of endothelin receptors in glaucomatous optic neuropathyRaghu R Krishnamoorthy; Fiscal Year: 2013..The information gained from this study could be useful in developing endothelin receptor antagonists as neuroprotective agents in glaucoma treatment. ..
- Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.David M Roth; Fiscal Year: 2013..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
- Control of Drug Delivery to the CNS: Modulating P-glycoprotein ActivityWilliam A Banks; Fiscal Year: 2013..abstract_text> ..
- Endothelin-1 and androgen in prostate cancer bone metastasis and bone healthGregory A Clines; Fiscal Year: 2013....
- PlGF-HIF1a-miRNA Axis in Sickle Pulmonary HypertensionPunam Malik; Fiscal Year: 2013..These studies will likely provide new diagnostic bio-markers for assessment of PHT, and novel therapeutic targets for a disease that currently has few or no therapeutic options. ..
- Cerebral Malaria: Mechanisms of disease and neurological salvageMahalia S Desruisseaux; Fiscal Year: 2013..Thus, vascular compromise and alterations in Akt and tau may be important in the pathogenesis of malaria and may provide rational targets of drug therapy to ameliorate the consequences of this infection. ..
- TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGNamasivayam Ambalavanan; Fiscal Year: 2012....
- Genetic Basis for Impaired Angiogenic Signaling in BPDSTEVEN HERBERT ABMAN; Fiscal Year: 2012..abstract_text> ..
- Pathogenesis of cognitive/neurologic deficits in central nervous system malariaChandy C John; Fiscal Year: 2012..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
- Antenatal betamethasone for persistent pulmonary hypertension of newbornGirija G Konduri; Fiscal Year: 2010..The proposed studies will investigate the role of antenatal betamethasone to restore normal vascular function to the infant's lungs before birth to avoid periods of hypoxemia. ..
- Vascular Mechanisms in Pregnancy-Induced HypertensionRaouf A Khalil; Fiscal Year: 2013....
- SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORSPhilip B Wedegaertner; Fiscal Year: 2013..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura V Gonzalez Bosc; Fiscal Year: 2012..A better understanding of this mechanisms in PAH will lead to the development of novel therapeutic approaches to prevent and cure this debilitating disease. ..
- Insulin action in human cardiac and skeletal muscle microvasculatureZhenqi Liu; Fiscal Year: 2013....
- Endothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedMike T Lin; Fiscal Year: 2011..in vascular endothelium is a key regulator for many of the endothelium-derived vasoactive factors, including endothelins, prostaglandins, nitric oxide, and endothelium- derived hyperpolarizing factor (EDHF)...
- Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular reactFrank W Sellke; Fiscal Year: 2013..The results of these studies may have significant implications regarding the recovery of diabetic and other patients after cardiac surgery involving cardioplegia and CPB. ..
- Impact of obesity on airway responses to air pollutionStephanie A Shore; Fiscal Year: 2013..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to new therapeutic strategies for this increasingly at risk population. ..
- Prostacyclin Synthase and Receptors in Pulmonary Arterial HypertensionMark W Geraci; Fiscal Year: 2011....
- Novel functions of RGS3Nickolai O Dulin; Fiscal Year: 2012..Therefore, defining the molecular mechanisms of T cell activation and differentiation may lead to a better understanding the pathogenesis of these diseases. ..
- Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger TranscripDavid Sherris; Fiscal Year: 2010..Work from this project will further advance our knowledge on zinc finger protein transcription factor/DNA interactions and may thus open the door to a whole new range of therapeutic agents. ..
- Hypertension, Kidney and PregnancyJoey P Granger; Fiscal Year: 2013..Based on preliminary data presented in this application, we propose that induction of hemeoxygenase-1 and its catalytic products, carbon monoxide and bilirubin, may provide a novel therapeutic approach for the treatment of PE. ..
- The Kidney, Hypertension, Pregnancy and InflammationBabbette LaMarca; Fiscal Year: 2013....
- Modulating Secondary Damage Following Traumatic Brain Injury in the ChildStuart H Friess; Fiscal Year: 2013..The goal of this proposal is to develop new and effective therapies to treat acute traumatic brain injury in children utilizing an immature large animal model. ..
- Insulin as a Regulator of Microvascular ExchangeVirginia H Huxley; Fiscal Year: 2013..abstract_text> ..
- Functional characterization of ATP1A1 and DEspR variants associated with essentiaNelson Ruiz Opazo; Fiscal Year: 2010....
- Role of Endothelin B Receptor in Vascular Protection in FemalesRaouf A Khalil; Fiscal Year: 2011....
- Mechanisms of Cardiac Afferents and CNS Reflex ProcessingJohn C Longhurst; Fiscal Year: 2013..Additional knowledge derived from these studies will allow a better understanding of the mechanisms underlying the genesis of angina pectoris and reflex activation of the cardiovascular system during myocardial ischemia and reperfusion. ..
- Effects of insulin on the microvasculatureEUGENE JOSEPH BARRETT; Fiscal Year: 2013....
- Human Aging, Exercise &FMD: Translational PhysiologyDouglas R Seals; Fiscal Year: 2013.._OVIDED. University of Colorado-Boulder, Boulder, Colorado ..
- CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKECostantino Iadecola; Fiscal Year: 2013..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
- The role of T lymphocytes in mediating hypertension during pregnancyKedra L Wallace; Fiscal Year: 2013..To test the hypothesis that Endothelin-1 and ROS facilitate T lymphocyte mediated AT1-AA induced increases blood pressure response to placental ischemia in pregnant rats . ..
- Obesity, vascular inflammation, and immune cell activation in prehypertensionSuzi Hong; Fiscal Year: 2013....
- Preeclampsia, IUGR and Hypertension: Targets for TreatmentJoey P Granger; Fiscal Year: 2013....
- The Association of Chronic Exposure to Particulate Matter Air Pollutants, InflammRODRIGO XAVIER ARMIJOS; Fiscal Year: 2013..The samples will be analyzed using an automated energy dispersive XRF instrument. . ..
- Cell Free O2 Carriers: Cerebrovascular Control and StrokeRAYMOND CHARLES KOEHLER; Fiscal Year: 2013....
- Ah Receptor and Endothelin-Dependent HypertensionMary K Walker; Fiscal Year: 2010..Our results will define a novel regulatory pathway for suppression of hypoxia-induced ET- 1, which could be use to develop new therapies for ET-1-dependent cardiovascular diseases. ..
- Regulation of Rho Signaling by S-NitrosothiolsA Richard Whorton; Fiscal Year: 2012..abstract_text> ..
- Internalization of gap junctions as a regulatory mechanism of direct GJICMatthias M Falk; Fiscal Year: 2013....
- Rho-kinase signaling in lung development and persistent pulmonary hypertensionJason Gien; Fiscal Year: 2013..The strength of this proposal is the assembly of several successful scientists who will assure both progress and success in my research career and guide me towards independence as a physician scientist. ..
- Low birth weight, the kidney, and hypertensionBarbara T Alexander; Fiscal Year: 2013..abstract_text> ..
- Biological Mechanisms of Arterial Stiffening With Age and Estrogen DeficiencyKERRIE MOREAU; Fiscal Year: 2010..The results should provide new insight into the integrative biological mechanisms by which sex hormone deficiency modulates the age-related reduction in large artery compliance in women as they transition through the menopause. ..
- Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar DysfunctionTravis W Hein; Fiscal Year: 2012..The results derived from these studies are essential to advance our understanding in the pathogenesis of retinal vascular disease associated with retinal ischemia and may suggest novel targets for future therapeutic interventions...
- Aging, Sleep Apnea, and Vascular Control During Systemic HypoxiaFrank A Dinenno; Fiscal Year: 2013....
- Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular DiseaseDavid J Moser; Fiscal Year: 2012..abstract_text> ..
- Ednrb Regulation of Gastrointestinal MotilityKENT CHARLES WILLIAMS; Fiscal Year: 2013..abstract_text> ..
- SPORE IN PROSTATE CANCERWILLIAM GEORGE NELSON; Fiscal Year: 2013..The Research Projects are supported by an Administrative Core (A), which also manages inter-SPORE collaborations, a Tissue Archive Core (B), and a Biostatistics and Epidemiology Core (C). ..
- Evaluation of In Vitro Companion Diagnostic Monoclonal Antibodies for Use in a StChristopher Horvath; Fiscal Year: 2013..Combined use of anti-DEspR companion diagnostic and therapeutic mAbs has the potential to alter oncology clinical practice, particularly in BCa/TNBC, as an addition to or advantage over existing treatments. ..
- Oxidant signaling for airway remodeling and inflammationYUICHIRO JUSTIN SUZUKI; Fiscal Year: 2012..In addition, the results will fundamentally advance the field of lung cell biology. (End of Abstract) ..
- BK Virus Receptor and polyomavirus nephropathyAndrey Sorokin; Fiscal Year: 2012..b>Endothelins (ET), agonists of G- protein coupled receptors;act as important mediators of renal disease progression...
- Domains of Inflammation and Risk of DementiaAnnette L Fitzpatrick; Fiscal Year: 2013..Assessment of these biomarkers to predict risk of dementia prior to cognitive symptoms emerging will increase ability to develop strategies of prevention and early detection. ..
- Molecular and Genetic Regulation of Craniofacial DevelopmentBrian L Black; Fiscal Year: 2013..The goals are to place Mef2c into a transcriptional pathway and to identify the immediate transcriptional effectors of endothelin signaling in craniofacial development. ..
- ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSIONJohn Murray; Fiscal Year: 1993....
- Endothelin-2 in Ovarian Follicle RuptureChemyong Ko; Fiscal Year: 2010..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. ..
- ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCEKieren Mather; Fiscal Year: 2003..If the data confirm our hypothesis, treatment of IR patients with ET1 antagonists may be a rational and beneficial approach to reducing the dreaded cardiovascular outcomes associated with IR and type 2 diabetes. ..
- Chemokine-endothelin interaction & Chagas' diseaseHerbert Tanowitz; Fiscal Year: 2006..The research will be performed primarily at the Brazil site in collaboration with Herbert Tanowitz at the US site as extension of NIH Grant AI-12770 [unreadable] [unreadable]..
- Role of NO and Endothelin in Human NECGAIL BESNER; Fiscal Year: 2007..If successful, these data could provide a platform for a prospective, randomized trial of new medical therapeutic strategies for NEC, e.g., the pharmacological manipulation of endothelin receptors. [unreadable] [unreadable]..
- Genetic Risk Factors for Portopulmonary HypertensionSteven Kawut; Fiscal Year: 2005..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
- ABNORMAL TERMINAL COLON OF THE 1S/1S MUTANT MOUSETAUBE ROTHMAN; Fiscal Year: 2000..They propose this occurs because EDNRBs and EDN3 expression occurs only in the colon and not the small intestine. Therefore, they will compare the expression of EDN3 and EDNRB in the colon and small intestine to see if this is correct. ..