cytokines

Summary

Summary: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Top Publications

  1. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
  2. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
  3. ncbi Pathogen recognition and innate immunity
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Cell 124:783-801. 2006
  4. doi Alternative activation of macrophages: mechanism and functions
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunity 32:593-604. 2010
  5. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
  6. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
  7. pmc Differentiation of effector CD4 T cell populations (*)
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Annu Rev Immunol 28:445-89. 2010
  8. doi Growth factors and cytokines in wound healing
    Stephan Barrientos
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Wound Repair Regen 16:585-601. 2008
  9. ncbi The two NF-kappaB activation pathways and their role in innate and adaptive immunity
    Giuseppina Bonizzi
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Trends Immunol 25:280-8. 2004
  10. ncbi Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
    Blood 99:3838-43. 2002

Detail Information

Publications298 found, 100 shown here

  1. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
    ..Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated...
  2. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
    ..We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations...
  3. ncbi Pathogen recognition and innate immunity
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Cell 124:783-801. 2006
    ..New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity...
  4. doi Alternative activation of macrophages: mechanism and functions
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunity 32:593-604. 2010
    ..in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and ..
  5. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
  6. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
    In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour...
  7. pmc Differentiation of effector CD4 T cell populations (*)
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Annu Rev Immunol 28:445-89. 2010
    ..their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
  8. doi Growth factors and cytokines in wound healing
    Stephan Barrientos
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Wound Repair Regen 16:585-601. 2008
    ..process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines and chemokines...
  9. ncbi The two NF-kappaB activation pathways and their role in innate and adaptive immunity
    Giuseppina Bonizzi
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Trends Immunol 25:280-8. 2004
  10. ncbi Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
    Blood 99:3838-43. 2002
    ....
  11. pmc Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
    Menno D de Jong
    Oxford University Clinical Research Unit, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam
    Nat Med 12:1203-7. 2006
    ..The focus of clinical management should be on preventing this intense cytokine response, by early diagnosis and effective antiviral treatment...
  12. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype...
  13. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and cytokines in response to IL-1...
  14. pmc Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    Peter C Heinrich
    Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 374:1-20. 2003
    The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the ..
  15. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
  16. pmc Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:732-41. 2009
    ..depression have been found to exhibit increased peripheral blood inflammatory biomarkers, including inflammatory cytokines, which have been shown to access the brain and interact with virtually every pathophysiologic domain known to be ..
  17. ncbi Regulation of the germinal center response by microRNA-155
    To Ha Thai
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 316:604-8. 2007
    ..miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo...
  18. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  19. pmc Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
    Nikhil S Joshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:281-95. 2007
    ..The decision between SLEC and MPEC fates was regulated by the amount of inflammatory cytokines (i.e., IL-12) present during T cell priming...
  20. ncbi Pathogenesis and therapy of psoriasis
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA
    Nature 445:866-73. 2007
    ..thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis...
  21. ncbi An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
    ..These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system...
  22. ncbi Microglia as a source and target of cytokines
    Uwe Karsten Hanisch
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Glia 40:140-55. 2002
    b>Cytokines constitute a significant portion of the immuno- and neuromodulatory messengers that can be released by activated microglia...
  23. ncbi Adipose tissue, inflammation, and cardiovascular disease
    Anders H Berg
    Department of Cell Biology, Bronx, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 96:939-49. 2005
    ..The targeted suppression of various proinflammatory cascades in adipocytes specifically represents an exciting new therapeutic opportunity for the cardiovascular disease area...
  24. ncbi The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
    L Bingle
    Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
    J Pathol 196:254-65. 2002
    ..It also outlines the range of pro- and anti-tumour functions performed by TAMs, and the novel therapies recently devised using TAMs to stimulate host immune responses or deliver therapeutic gene constructs to solid tumours...
  25. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
    ..importance of the IL-1R accessory protein, newly discovered signal transduction pathways, naturally occurring cytokines limiting IL-1 production or activity, the effects of blocking cyclooxygenase and nitric oxide, and the outcomes ..
  26. pmc Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1616, USA
    Science 327:1098-102. 2010
    ..These T cells specialize to become distinct subsets and produce restricted patterns of cytokines, which are tailored to combat various microbial pathogens...
  27. ncbi Neuroglial activation and neuroinflammation in the brain of patients with autism
    Diana L Vargas
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 57:67-81. 2005
    ..chemoattractant protein (MCP)-1 and tumor growth factor-beta1, derived from neuroglia, were the most prevalent cytokines in brain tissues. CSF showed a unique proinflammatory profile of cytokines, including a marked increase in MCP-1...
  28. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.
  29. doi Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Curr Opin Immunol 22:231-7. 2010
    ..TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression...
  30. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
    ..Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human T(H)-17 cells that promote the production of antimicrobial peptides in human keratinocytes...
  31. ncbi Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Immunol 6:772-83. 2006
    ..Understanding this rapidly growing family of mainly adipocyte-derived mediators might be of importance in the development of new therapies for obesity-associated diseases...
  32. doi Inflammatory bowel disease
    Arthur Kaser
    Department of Medicine II, Medical University Innsbruck, Austria
    Annu Rev Immunol 28:573-621. 2010
    ..This review examines these interactions and, where possible, potential lessons from IBD-directed, biologic therapies that may allow for elucidation of pathways that are central to disease pathogenesis in humans...
  33. pmc The biological functions of T helper 17 cell effector cytokines in inflammation
    Wenjun Ouyang
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Immunity 28:454-67. 2008
    ..Th17 cells and their effector cytokines mediate host defensive mechanisms to various infections, especially extracellular bacteria infections, and are ..
  34. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  35. ncbi CD107a as a functional marker for the identification of natural killer cell activity
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Massachusetts, USA
    J Immunol Methods 294:15-22. 2004
    ..Cumulatively, the data presented here demonstrate that CD107a is a sensitive marker of NK cell activity...
  36. doi Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 88:1379-406. 2008
    Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested that cytokines and other peptides that are produced, expressed, and released by muscle fibers and exert paracrine, autocrine, or ..
  37. pmc How regulatory T cells work
    Dario A A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105 2794, USA
    Nat Rev Immunol 8:523-32. 2008
    ..In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate T(Reg)-cell function...
  38. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
    ..Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human T(H)-17 cells and ..
  39. pmc A mechanism for the initiation of allergen-induced T helper type 2 responses
    Caroline L Sokol
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connceticut 06510, USA
    Nat Immunol 9:310-8. 2008
    ..In addition, the cellular source of cytokines that control TH2 differentiation in vivo has not been defined...
  40. ncbi Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    J M Kyriakis
    Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Physiol Rev 81:807-69. 2001
    ..The nuclear factor-kappa B pathway, a second stress signaling paradigm, has been the subject of several excellent recent reviews (258, 260)...
  41. doi Transcriptional control of the inflammatory response
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Nat Rev Immunol 9:692-703. 2009
    ..Here, we discuss the mechanisms of and the emerging principles in the transcriptional regulation of inflammatory responses in diverse physiological settings...
  42. pmc Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    Warren Strober
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 140:1756-67. 2011
    ..In Crohn's disease, the major cytokines arise from T-helper cell (Th) 1 and Th17 CD4(+) T-cell differentiation and consist of interferon-γ and ..
  43. doi Plasticity of CD4+ T cell lineage differentiation
    Liang Zhou
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Immunity 30:646-55. 2009
    ..Here, we will discuss recent findings that demonstrate the plasticity of CD4(+) T cell differentiation and the biological implications of this flexibility...
  44. doi The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, Amsterdam, The Netherlands
    Nat Immunol 12:21-7. 2011
    ..Analogous to helper T cell subsets, these evolutionarily conserved yet distinct ILCs seem to have important roles in protective immunity, and their dysregulation can promote immune pathology...
  45. doi Innate IL-17-producing cells: the sentinels of the immune system
    Daniel J Cua
    Merck Research Laboratories, DNAX Discovery Research, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Rev Immunol 10:479-89. 2010
    ..These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antigen and initiates the T(H)17 cell developmental programme...
  46. pmc Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 101:890-8. 1998
    ..Therefore, it is likely that resolution of inflammation depends not only on the removal of apoptotic cells but on active suppression of inflammatory mediator production. Disorders in either could result in chronic inflammatory diseases...
  47. pmc T cell activation
    Jennifer E Smith-Garvin
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Immunol 27:591-619. 2009
    ..complex (MHC) complex pSMAC: peripheral supramolecular activation cluster PTK: protein tyrosine kinase Signal transduction: biochemical events linking surface receptor engagement to cellular responses TCR: T cell antigen receptor..
  48. ncbi IL-28, IL-29 and their class II cytokine receptor IL-28R
    Paul Sheppard
    ZymoGenetics, Inc, 1201 Eastlake Avenue E, Seattle, WA 98102, USA
    Nat Immunol 4:63-8. 2003
    b>Cytokines play a critical role in modulating the innate and adaptive immune systems...
  49. pmc CD4 T cells: fates, functions, and faults
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:1557-69. 2008
    ....
  50. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
    ..Owing to their early production of cytokines and chemokines, and ability to lyse target cells without prior sensitization, NK cells are crucial components of ..
  51. pmc Cell-mediated immune responses in tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:393-422. 2009
    ..We must also determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences...
  52. doi Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Nat Immunol 11:7-13. 2010
    ....
  53. ncbi Immunology of multiple sclerosis
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1400, USA
    Annu Rev Immunol 23:683-747. 2005
    ..It is now clear that MS is not just a disease of the immune system, but that factors contributed by the central nervous system are equally important and must be considered in the future...
  54. pmc Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    Harry Sokol
    Unité Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique U910, Domaine de Vilvert, 78350 Jouy en Josas, France
    Proc Natl Acad Sci U S A 105:16731-6. 2008
    ..These results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment...
  55. ncbi Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
    ..Endotoxin (lipopolysaccharide), produced by all gram-negative bacteria, activates macrophages to release cytokines that are potentially lethal...
  56. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette-Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
    ....
  57. doi Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 9:1341-6. 2008
    ..Thus, transforming growth factor-beta constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways.
  58. pmc Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    Robert J Johnston
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 325:1006-10. 2009
    ..These findings demonstrate that T(FH) cells are required for proper B cell responses in vivo and that Bcl6 and Blimp-1 play central but opposing roles in T(FH) differentiation...
  59. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages...
  60. doi A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    Elisabetta Volpe
    Institut National de la Sante et de la Recherche Medicale U653, Paris F 75248, France
    Nat Immunol 9:650-7. 2008
    ..methods, we show here that transforming growth factor-beta, interleukin 23 (IL-23) and proinflammatory cytokines (IL-1beta and IL-6) were all essential for human T(H)-17 differentiation...
  61. pmc Pyogenic bacterial infections in humans with MyD88 deficiency
    Horst von Bernuth
    Human Genetics of Infectious Diseases, INSERM U550, Paris, France
    Science 321:691-6. 2008
    ..The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections...
  62. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
  63. pmc TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
    Mark C Siracusa
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 477:229-33. 2011
    ....
  64. ncbi Inflammation and cancer: back to Virchow?
    F Balkwill
    ICRF Translational Oncology Laboratory, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Lancet 357:539-45. 2001
    ..We suggest that the inflammatory cells and cytokines found in tumours are more likely to contribute to tumour growth, progression, and immunosuppression than they ..
  65. ncbi SOCS proteins, cytokine signalling and immune regulation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Rev Immunol 7:454-65. 2007
    ..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
  66. ncbi Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    E A Tivol
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 3:541-7. 1995
    ..In the absence of CTLA-4, peripheral T cells are activated, can spontaneously proliferate, and may mediate lethal tissue injury...
  67. ncbi Immune function of microglia
    F Aloisi
    Neurophysiology Unit, Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Roma, Italy
    Glia 36:165-79. 2001
    ..This article focuses on the signals regulating microglia innate immune functions, the role of microglia in antigen presentation, and their possible involvement in the development of CNS immunopathology...
  68. ncbi Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    Julie K Olson
    Department of Microbiology Immunology and Interdepartmental Immunobiology Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 173:3916-24. 2004
    ..microglia infected with a neurotropic strain of Theiler's murine encephalomyelitis virus secreted innate immune cytokines and up-regulated costimulatory molecules and MHC class II, enabling the cells to present viral and myelin Ags to ..
  69. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    b>Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation...
  70. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
    ..Our data demonstrate a dichotomy in the generation of pathogenic (T(H)17) T cells that induce autoimmunity and regulatory (Foxp3+) T cells that inhibit autoimmune tissue injury...
  71. pmc Harmful molecular mechanisms in sepsis
    Daniel Rittirsch
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109 0602, USA
    Nat Rev Immunol 8:776-87. 2008
    ..In this Review, we highlight recent insights into the molecular interactions that occur during sepsis and attempt to unravel the nature of the dysregulated immune response during sepsis...
  72. ncbi The role for endoplasmic reticulum stress in diabetes mellitus
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Endocr Rev 29:42-61. 2008
    ..In vitro data suggest that ER stress may also contribute to cytokine-induced beta-cell death. Thus, the cytokines IL-1beta and interferon-gamma, putative mediators of beta-cell loss in type 1 diabetes, induce severe ER stress ..
  73. doi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    ..function of MSCs is elicited by IFNgamma and the concomitant presence of any of three other proinflammatory cytokines, TNFalpha, IL-1alpha, or IL-1beta...
  74. ncbi Inflammatory mediators in the elderly
    Karen Suarez Krabbe
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, M7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Exp Gerontol 39:687-99. 2004
    Ageing is accompanied by 2-4-fold increases in plasma/serum levels of inflammatory mediators such as cytokines and acute phase proteins...
  75. doi Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection
    Nadia Caccamo
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, University of Palermo, Palermo, Italy
    Eur J Immunol 40:2211-20. 2010
    Th1 CD4(+) T cells and their derived cytokines are crucial for protection against Mycobacterium tuberculosis...
  76. ncbi Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
    Darwyn Kobasa
    Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 445:319-23. 2007
    ..The ability of influenza viruses to modulate host immune responses, such as that demonstrated for the avian H5N1 influenza viruses, may be a feature shared by the virulent influenza viruses...
  77. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  78. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose ..
  79. pmc Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
    ..CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues...
  80. pmc Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    Dongsheng Cai
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Med 11:183-90. 2005
    ..The hepatic production of proinflammatory cytokines, including IL-6, IL-1beta and TNF-alpha, was increased in LIKK mice to a similar extent as induced by HFD in in ..
  81. pmc Cellular and molecular mechanisms of fibrosis
    T A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 214:199-210. 2008
    ..e. TLRs) on fibroblasts. Cytokines (IL-13, IL-21, TGF-beta1), chemokines (MCP-1, MIP-1beta), angiogenic factors (VEGF), growth factors (PDGF), ..
  82. ncbi Inflammatory blockade restores adult hippocampal neurogenesis
    Michelle L Monje
    Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Science 302:1760-5. 2003
    ....
  83. pmc Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
    Benjamin N Gantner
    Department of Immunology, University of Washington, Seattle, 98103, USA
    J Exp Med 197:1107-17. 2003
    ..particles, and in macrophages and dendritic cells dectin-1 and TLRs are synergistic in mediating production of cytokines such as interleukin 12 and tumor necrosis factor alpha...
  84. pmc Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
    Jesus F Bermejo-Martin
    National Centre of Influenza, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
    Crit Care 13:R201. 2009
    ..We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1...
  85. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
    ....
  86. ncbi n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 83:1505S-1519S. 2006
    ..to a range of acute and chronic human diseases and is characterized by the production of inflammatory cytokines, arachidonic acid-derived eicosanoids (prostaglandins, thromboxanes, leukotrienes, and other oxidized ..
  87. ncbi Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
    C Y Cheung
    Department of Microbiology, University of Hong Kong, Queen Mary Hospital, SAR, Hong Kong, China
    Lancet 360:1831-7. 2002
    ..The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role...
  88. doi Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection
    Kelvin K W To
    Infectious Disease Division, Queen Mary Hospital, State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China
    Clin Infect Dis 50:850-9. 2010
    ..Infections caused by the pandemic H1N1 2009 influenza virus range from mild upper respiratory tract syndromes to fatal diseases. However, studies comparing virological and immunological profile of different clinical severity are lacking...
  89. pmc Protective immune mechanisms in helminth infection
    Robert M Anthony
    The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 7:975-87. 2007
    ..Although similar cells and cytokines are evoked in response to infection by helminths as diverse as nematodes and schistosomes, the components of the ..
  90. doi Homeostasis of naive and memory T cells
    Charles D Surh
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 29:848-62. 2008
    ..Typical memory cells are kept alive and induced to divide intermittently by a mixture of IL-7 and IL-15. This review highlights recent advances in how naive and memory T cell homeostasis is regulated...
  91. doi Diversity and dialogue in immunity to helminths
    Judith E Allen
    Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, UK
    Nat Rev Immunol 11:375-88. 2011
    ..Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity...
  92. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..is a stereotyped host response to allergens and parasitic helminths that is sustained in large part by the cytokines IL-4 and IL-13...
  93. ncbi Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    Atsunori Fukuhara
    Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Science 307:426-30. 2005
    ..Surprisingly, visfatin binds to and activates the insulin receptor. Further study of visfatin's physiological role may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes...
  94. ncbi Cytokines in the pathogenesis of rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 7:429-42. 2007
    b>Cytokines regulate a broad range of inflammatory processes that are implicated in the pathogenesis of rheumatoid arthritis...
  95. pmc TLR4 links innate immunity and fatty acid-induced insulin resistance
    Hang Shi
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:3015-25. 2006
    ....
  96. pmc New insights into the regulation of T cells by gamma(c) family cytokines
    Yrina Rochman
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Nat Rev Immunol 9:480-90. 2009
    Common cytokine receptor gamma-chain (gamma(c)) family cytokines have crucial roles in the development, proliferation, survival and differentiation of multiple cell lineages of both the innate and adaptive immune systems...
  97. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..analysis of IL-23-driven autoreactive T cells identified a unique expression pattern of proinflammatory cytokines and other novel factors, distinguishing them from IL-12-driven T cells...
  98. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    ..Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy...
  99. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  100. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..We therefore examined prospectively the effects of the central inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) on the development of type 2 diabetes...
  101. doi Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    Subhra K Biswas
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    Nat Immunol 11:889-96. 2010
    ..A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention...

Research Grants77

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..b>Cytokines secondary to inflammation and exogenous treatment with steroids can cause mood and cognitive changes in these ..
  2. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..both "traditional" markers such as eosinophilia, exhaled NO (eNO) and sinus CT score;as well as measurements of cytokines in serum and leukotrienes in urine...
  3. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..measures will be alpha-1 microglobulin, a marker of tubular injury, and urinary excretion of inflammatory cytokines and C-C chemokines, i.e. markers of renal inflammation...
  4. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..As in many autoimmune diseases, CD4+ T cells play a key role in MS and EAE through production of cytokines such as interferon-g and interleukin-17...
  5. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..Central and peripheral cytokines produced in response to viral infections or other inflammatory stimuli may be implicated, but there is no ..
  6. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), upregulation of cytokines [IL1b, IL6, IL8, TNF-a, vascular endothelial growth factor (VEGF)]...
  7. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..b>Cytokines and growth factors such as transforming growth factor (TGF-Beta) and connective tissue growth factor (CTGF) ..
  8. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..glucose homeostasis, lipid profile, free fatty acids, serum total and free testosterone and IGF-1), and cytokines (c-reactive protein, tumor necrosis factor alpha and IL-6 as inflammatory biomarkers) after 16 weeks of training+..
  9. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..One of the pro-inflammatory cytokines that drives this metabolic shunt towards KYN synthesis is interleukin 6 (IL6), an effect that is partly ..
  10. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..Recognition of HMBPP activates 34 T cells to produce Th1 cytokines, kill infected cells, and produce growth factors to repair mucosal surfaces...
  11. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..Upon recognition of their cognate antigen, Th2 cells produce cytokines that regulate IgE synthesis (IL-4 and IL-13), and growth and activation of eosinophils (IL-5) and mast cells (IL-..
  12. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..Core and a Biostatistics/Bioinformatics core that also will assist with the multi-parameter analysis of cytokines. Methods employed will include cutting edge genetic technologies as well as in vivo models of important immune ..
  13. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..predicted to abrogate the potential adverse effects of the anti-A( immunotherapy by increasing anti-inflammatory cytokines in the brain, as well as by slowing the maturation of the microglia into the pro-inflammatory antigen presenting ..
  14. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..by studying interaction of *0401 and *0402 with calreticulin, and role of T regulatory cells and Th17 cytokines. As a corollary, we will study mechanism of remission during pregnancy by studying function of T regulatory ..
  15. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..Its production is stimulated by inflammatory cytokines and hepcidin itself is anti-inflammatory...
  16. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..g. perlecan and syndecan-1, provides a structural network that sequesters cytokines in hypertrophic cartilage, and network disruption may cause inappropriate signaling at the chondro-osseous ..
  17. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..the effects of cytokines on the hepcidin/erythropoiesis relationship;E...
  18. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..Expression of C2GnT-M gene can be inhibited by epidermal growth factor but enhanced by retinoic acid and Th2 cytokines. C2GnT-M activity also can be regulated at the substrate level...
  19. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..While these approaches can induce T cell tolerance, they do not impact on the generation of proinflammatory cytokines and chemokines that are induced by conditioning therapy and critical to the development of GVHD...
  20. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..The second aim is to establish the relevance of the potency of Cryab by comparing the modulation of inflammatory cytokines with that observed for treatment with murine activated protein C...
  21. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..mice that the immune response to CII is enhanced with increased production of interferon3 and other Th1 cytokines, increased serum levels of anti-CII antibodies, decreased CD8+ T cells, increased CD11b+ cells and changes in ..
  22. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..These cells are highly proinflammatory releasing large amounts of tissue cytokines which can cause insulin resistance through paracrine mechanisms...
  23. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..bacteria and viruses gives rise to classically activated macrophages (CAMF), which produce pro- inflammatory cytokines (e.g., TNF, IL-12, IL-23) and nitric oxide (NO) that, together, drive potent anti-microbial functions...
  24. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..Maternal obesity exposes the placental-fetal unit to pro-inflammatory molecules. Inflammatory cytokines inhibit fatty acid uptake in the liver, muscle and heart...
  25. MODULATION OF IFN ACTION VIA NOVEL REGULATORY FACTORS
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The interferon family of cytokines is critical for promoting several physiologic processes, such as antiviral, antitumor, and immune responses...
  26. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..mediators include infiltrating leukocytes and myeloperoxidase (MPO), COX-2, PGE2, and several pro-inflammatory cytokines, TNF-1, IL-2, and IL-6. Specific Aim 4...
  27. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..ICSBP-deficient myeloid progenitor cells exhibit resistance to apoptosis, hypersensitivity to hematopoietic cytokines, and the tendency to accumulate additional genetic lesions...
  28. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..mucin gene in addition to other modifications, such as airway remodeling and elevated presence of inflammatory cytokines in airways...
  29. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..09, (p<0.02), increased levels of pro-inflammatory cytokines (p<0.01) and increased risk of developing Abs to mismatched donor HLA (p<0.001)...
  30. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid ..
  31. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..regulation of activated STAT3 in the tumor, and normalization of elevated levels of VEGF and other inflammatory cytokines observed in sera of tumor-bearing mice...
  32. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..Dramatic changes occur in the expression of neurotransmitter receptors, voltage gated ion channels, inflammatory cytokines, and a variety of other proteins in response to seizure activity...
  33. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..of high stringency, JAK2 kinase was identified as hBVR binding partner;hBVR, STAT1 and Elk are activated by cytokines. Presently, we hypothesize that BVR functions in defining cytoskeletal organization and regulation of cell cycle ..
  34. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..via changes of extracellular matrix (ECM) and contractile issues, and inflammatory cell infiltrate and cytokines. In conclusion, by targeting IgE constant regions, PIT regimens may alleviate IgE- mediated diseases by a myriad ..
  35. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..b>Cytokines CXCL10, CXCL11, IL-7, RANTES and BAFF are induced 337, 45, 128, 84 and 119 fold, respectively, in synchronously ..
  36. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ..Murine models and human clinical studies show roles for the same specific cytokines and TLR4 signaling in UTI...
  37. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..Maternal obesity exposes the placental-fetal unit to pro-inflammatory molecules. Inflammatory cytokines inhibit fatty acid uptake in the liver, muscle and heart...
  38. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN-g)...
  39. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..This is caused by release of free radical and reactive oxygen species (ROS) and inflammatory cytokines (e.g., TNF-1) from the activated neutrophils infiltrating the lungs...
  40. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..This general system is stimulation of unfractionated bone marrow aspirates with cytokines and measuring the fine kinetics of modified epitopes on signaling proteins by immunofluorescence flow cytometry...
  41. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..In the first aim we will determine whether hBD-1 is stimulated by HSV-1 via a direct pathway or whether cytokines and chemokines influence the induction via an indirect mechanism...
  42. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..The increase in abdominal fat, also known as visceral fat is known to produce cytokines that cause inflammation which can lead to the metabolic syndrome...
  43. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..This dampens the immune response by reducing the production of pro-inflammatory cytokines and chemokines...
  44. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many TGF-b (transforming growth factor)/BMP (bone morphogenetic protein) cytokines stimulate pluripotent mesenchymal cells to proliferate and differentiate into the chondrocytes and osteoblasts that ..
  45. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..In leukocyte-free first trimester decidual cells, we found that the pro-inflammatory cytokines, tumor necrosis factor-a (TNF-1) and interleukin-1 beta (IL-12), profoundly enhanced expression of macrophage-..
  46. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..This hypothesis will be tested with the following Specific Aims: SA1. Determine the time course over which cytokines involved in stem cell homing and tissue repair are upregulated by the genitourinary organs after vaginal ..
  47. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..Plasma and tissue concentrations of adrenal steroids and proinflammatory cytokines associated with mineralocorticoid- induced end-organ damage will be measured by ELISA...
  48. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Furthermore these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis...
  49. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..that obesity is associated with chronic inflammation-characterized by increased production and secretion of cytokines/chemokines by adipose tissue (AT) and liver-and with increased hepatic production of triglyceride-rich ..
  50. A2b Adenosine Receptor Regulation of Metabolic Disease and Inflammation
    Anna Eisenstein; Fiscal Year: 2013
    ..signaling through the A2b adenosine receptor (A2bAR) has been shown to dampen the release of inflammatory cytokines. Furthermore, administration of a high fat, high cholesterol diet (HFD) vastly upregulates the expression of the ..
  51. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
    ..signaling molecules that regulate crypt cell proliferation (Bmps and Bmp inhibitors) and modulate inflammation (cytokines)...
  52. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..Damage to endothelial cells is mediated by IFN- 1 and TNF-1, and both cytokines are increased in JDM sera and tissue...
  53. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..by applicant): Abstract Description: In rheumatoid arthritis (RA), an inflammatory stimulus from secreted cytokines increases osteoclast activity, erodes bone surfaces, and progressively destroys joints...
  54. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ..78 and related cell death pathways, and inflammatory responses by proinflammatory transcription factors and cytokines in the pancreas and/or plasma...
  55. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..Similarly, SIRT1-deficient mice exhibited exaggerated levels of NF-(B and proinflammatory cytokines associated with increased influx of neutrophils, whereas these responses were attenuated in lungs of SIRT1 ..
  56. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..Increased expression of proinflammatory cytokines in the marrow preceded activation of osteoclasts, which was followed by evidence (indicated by phosphoSmad2) of ..
  57. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..measures will be alpha-1 microglobulin, a marker of tubular injury, and urinary excretion of inflammatory cytokines and C-C chemokines, i.e. markers of renal inflammation...
  58. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..the egress of T cells from the lymph node but it is also necessary for the activity of several inflammatory cytokines with known importance in LGL leukemia and other autoimmune diseases...
  59. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Several years ago multiple different investigators found a new subset of T cells that generate the cytokines IL- 17A, IL-17F, IL-21, IL-22, and TNF- ...
  60. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..Experimental manipulations (i.e. gene knockout, blocking antibodies, and cytokines) that have been so powerful for dissecting the molecular basis of mouse immunology are rarely possible in humans...
  61. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..DCs) convert dietary VitA to retinoic acid (RA) and DCs and/or RA in concert with key signaling molecules (cytokines, inflammatory mediators), imprint gut homing (CCR9, a4[unreadable]7) on T and B cells, promote isotype switching ..
  62. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..stimulate immune and epithelial cells via the neurokinin-1 receptor, causing the release of proinflammatory cytokines and IFN-? and activation of NF-?B...
  63. Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
    JEREL ADAM FIELDS; Fiscal Year: 2011
    ..by an accumulation of activated and infected macrophages/microglia in the central nervous system, which secrete cytokines, infectious virions and viral proteins that activate surrounding astrocytes leading to astrogliosis and altered ..
  64. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..recognized as key mediators of inflammation, and are known to mediate the effects of pro-inflammatory cytokines such as tumor necrosis factor-? (TNF?) that are of central importance in IBD...
  65. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ..There is growing evidence that infection with HIV-1 can stimulate the formation of inflammatory cytokines such as TNF-alpha and IL1-beta...
  66. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..The obese, pregnant woman has increased serum levels of pro-inflammatory cytokines and low circulating levels of adiponectin leading to decreased insulin sensitivity, which has been suggested to ..
  67. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald L Jarvis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Many biomedically significant proteins, including antibodies, cytokines, anticoagulants, blood clotting factors, and others are glycoproteins...
  68. UROTHELIAL CELL ACTIVATION IN INTERSTITIAL CYSTITIS
    Monica Liebert; Fiscal Year: 1993
    ..We hypothesize that this condition is due to or is exacerbated by the production of cytokines by the urothelial cells of the bladder, and that the local action of immunosuppressive drugs, such as ..
  69. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2010
    ..elicit different cytokine/chemokine profiles as compared to irritants in skin, yet it is not known if specific cytokines are associated with irritant type or strength...
  70. CYTOKINE EFFECTS IN HYPOTHALAMUS/STEROID MODULATION
    Pushpa Kalra; Fiscal Year: 1999
    b>Cytokines, the integral arm of bidirectional communication between the immune and central nervous systems, are also constitutive components of the hypothalamus where they may act as interneuronal signals...
  71. Biologic scaffold prostheses to enhance meniscus repair
    JOE WEINBERG; Fiscal Year: 2009
    ..We have also shown that mechanical stress and cytokines alter the metabolism of menisci and inhibit repair of meniscal injury...
  72. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ..Cell-medicated immunity is controlled by two major categories of cytokines. The Th1 cytokines, such as interferon gamma (IFN-g), interleukin 2 (IL-2) and interleukin 12 (IL-12), favor the ..
  73. JAK-3 AND MYELOID CELL DIFFERENTIATION
    E Reddy; Fiscal Year: 2000
    ..which include JAK1, JAK2, and TYK2) that play a pivotal role in the signal transduction process mediated by cytokines and interferons...
  74. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and cytokines in the brain...
  75. Innate Immune Bacterial Recognition and Osteoclastogenesis
    Caroline A Genco; Fiscal Year: 2010
    ..have been reported to contribute to the acceleration of bone resorption by the production of proinflammatory cytokines including tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, and receptor activator of nuclear factor B ..
  76. Role(s) of VEGF in Resolution of Inflammation
    Manuela M Martins Green; Fiscal Year: 2010
    Inflammation is a key process in normal wound repair. Upon wounding, cytokines are activated and chemoattract leukocytes, including macrophages, to the wound site...
  77. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..CD4 Th1 cells invariably display differential expression of MIP-1[unreadable] vs. other Th1 cytokines such as IFN-?, IL-2, and TNF- a, and the overall profiles of chemokines and cytokines produced by the responding ..