endostatins

Summary

Summary: Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.

Top Publications

  1. ncbi Endostatin inhibits lymph node metastasis by a down-regulation of the vascular endothelial growth factor C expression in tumor cells
    Shunsuke Fukumoto
    Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 1 1 Maidashi 3 chome, Higashi ku, Fukuoka 812 8582, Japan
    Clin Exp Metastasis 22:31-8. 2005
  2. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
  3. ncbi Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
    Yun Ling
    Department of Physiology, China Pharmaceutical University, Nanjing 210009, China
    Biochem Biophys Res Commun 361:79-84. 2007
  4. doi Process in the mechanisms of endostatin combined with radiotherapy
    Hong Qing Zhuang
    Department of Radiotherapy, Tianjin Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China
    Cancer Lett 282:9-13. 2009
  5. doi Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels
    Tri Minh Bui Nguyen
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Mol Med 13:3687-98. 2009
  6. ncbi Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma
    F Bertolini
    Haematology Oncology, IRCCS European Institute of Oncology, Milan, Italy
    Br J Haematol 106:504-9. 1999
  7. pmc Molecular interplay between endostatin, integrins, and heparan sulfate
    Clément Faye
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS University Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    J Biol Chem 284:22029-40. 2009
  8. ncbi Generation and degradation of human endostatin proteins by various proteinases
    M Ferreras
    OSTEOPRO and Center for Clinical and Basic Research Herlev Ballerup, Herlev, Denmark
    FEBS Lett 486:247-51. 2000
  9. ncbi RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism
    Kim Henriksen
    Nordic Bioscience, Herlev DK 2730, Denmark
    J Biol Chem 278:48745-53. 2003
  10. ncbi Clinical studies of angiogenesis inhibitors: the University of Texas MD Anderson Center Trial of Human Endostatin
    R S Herbst
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Box 80, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Curr Oncol Rep 3:131-40. 2001

Research Grants

  1. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2010
  2. Tropomyosin in the antiangiogenic activity of HKa
    Keith McCrae; Fiscal Year: 2007
  3. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2010
  4. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Olsen; Fiscal Year: 2009
  5. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2009
  6. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2010
  7. Regulation of angiogenic balance by thrombospondin-1
    Olga Volpert; Fiscal Year: 2004
  8. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
  9. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
  10. ANTI ANGIOGENIC ACTIVITY OF CLEAVED HMW KININOGEN
    Keith McCrae; Fiscal Year: 2004

Detail Information

Publications269 found, 100 shown here

  1. ncbi Endostatin inhibits lymph node metastasis by a down-regulation of the vascular endothelial growth factor C expression in tumor cells
    Shunsuke Fukumoto
    Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 1 1 Maidashi 3 chome, Higashi ku, Fukuoka 812 8582, Japan
    Clin Exp Metastasis 22:31-8. 2005
    ..These findings suggested that endostatin inhibited lymphangiogenesis and lymph node metastasis by suppressing the production of VEGF-C in tumor cells...
  2. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
    ..Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy...
  3. ncbi Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
    Yun Ling
    Department of Physiology, China Pharmaceutical University, Nanjing 210009, China
    Biochem Biophys Res Commun 361:79-84. 2007
    ..Collectively, these data indicated the relationship between endostar and VEGF signal pathways and provided a molecular basis for the antiangiogenic effects of endostar...
  4. doi Process in the mechanisms of endostatin combined with radiotherapy
    Hong Qing Zhuang
    Department of Radiotherapy, Tianjin Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China
    Cancer Lett 282:9-13. 2009
    ..Endostatin in combination with RT has feasibility; but it also has lots of problems. Further understanding of the mechanisms is needed...
  5. doi Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels
    Tri Minh Bui Nguyen
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Mol Med 13:3687-98. 2009
    ..Thus, interfering with autophagy can potentiate the effects of endostatin by promoting a switch to apoptosis...
  6. ncbi Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma
    F Bertolini
    Haematology Oncology, IRCCS European Institute of Oncology, Milan, Italy
    Br J Haematol 106:504-9. 1999
    ..Our data suggest that b-FGF and, particularly, VEGF might be considered prognostic factors in NHL staging and management...
  7. pmc Molecular interplay between endostatin, integrins, and heparan sulfate
    Clément Faye
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS University Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    J Biol Chem 284:22029-40. 2009
    ..5 nM). The direct binding between integrins and heparin/heparan sulfate might explain why both heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts...
  8. ncbi Generation and degradation of human endostatin proteins by various proteinases
    M Ferreras
    OSTEOPRO and Center for Clinical and Basic Research Herlev Ballerup, Herlev, Denmark
    FEBS Lett 486:247-51. 2000
    ..None correspond to mouse endostatin. However, the efficiencies of these proteinases differed markedly. Some proteinases also proved to degrade endostatin, pointing to another regulatory loop of angiogenesis...
  9. ncbi RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism
    Kim Henriksen
    Nordic Bioscience, Herlev DK 2730, Denmark
    J Biol Chem 278:48745-53. 2003
    ..Taken together, these results show that RANKL and VEGF, in addition to their role in osteoclast differentiation and activation of resorption, are important components of the processes regulating osteoclast chemotaxis...
  10. ncbi Clinical studies of angiogenesis inhibitors: the University of Texas MD Anderson Center Trial of Human Endostatin
    R S Herbst
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Box 80, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Curr Oncol Rep 3:131-40. 2001
    ..This article defines the general principles of anti-angiogenic drug action and explains how these principles have been used to design a phase I trial of human endostatin...
  11. ncbi Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice
    Gaelle Brideau
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    Cancer Res 67:11528-35. 2007
    ....
  12. ncbi Recombinant human endostatin, Endostar, enhances the effects of chemo-radiotherapy in a mouse cervical cancer xenograft model
    Y Jia
    Oncology Department, Hebei General Hospital, Shijiazhuang, Hebei, China
    Eur J Gynaecol Oncol 32:316-24. 2011
    ..The effects of recombinant human endostatin, Endostar, combined with concurrent chemo-radiotherapy (CCRT) on tumor growth, angiogenesis and lymphangiogenesis in a mouse xenograft model of cervical cancer was investigated...
  13. ncbi Anti-angiogenic activity of human endostatin is HIF-1-independent in vitro and sensitive to timing of treatment in a human saphenous vein assay
    Gordon R Macpherson
    Molecular Pharmacology Laboratory, Laboratory of Receptor Biology and Gene Expression, and Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cancer Ther 2:845-54. 2003
    ..In view of this in vitro data, we suggest that clinical trials involving endostatin treatment of late-stage disease may not adequately represent the efficacy of this drug in early-stage cancer...
  14. doi Endostar, a modified endostatin inhibits non small cell lung cancer cell in vitro invasion through osteopontin-related mechanism
    Qinggui Ni
    Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China
    Eur J Pharmacol 614:1-6. 2009
    ..Tumor cell invasion is important for tumor metastasis, our findings suggest that it is probably a good strategy to put Endostar into treatment of NSCLC metastasis...
  15. pmc Lack of collagen XVIII/endostatin results in eye abnormalities
    Naomi Fukai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:1535-44. 2002
    ..The findings provide an explanation for high myopia, vitreoretinal degeneration and retinal detachment seen in patients with Knobloch syndrome caused by loss-of-function mutations in collagen XVIII...
  16. pmc Endostatin gene variation and protein levels in breast cancer susceptibility and severity
    Sabapathy P Balasubramanian
    Academic Surgical Oncology Unit, University of Sheffield, Sheffield, UK
    BMC Cancer 7:107. 2007
    ..Endostatin protein expression on a breast cancer micro array was also studied to determine any relationship to genotype and to breast cancer prognosis...
  17. ncbi Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors
    G Perletti
    Dipartimento di Biologia Strutturale e Funzionale, Universita degli Studi dell Insubria, Varese, Italy
    Cancer Res 60:1793-6. 2000
    ..It not only stops the growth of existing tumors but also decreases the incidence of the development of multiple neoplastic lesions...
  18. ncbi Endostatin binds tropomyosin. A potential modulator of the antitumor activity of endostatin
    N J Macdonald
    EntreMed, Inc, 9640 Medical Center Dr, Rockville, MD 20850, USA
    J Biol Chem 276:25190-6. 2001
    ..We postulate that the Endostatin interaction with tropomyosin results in disruption of microfilament integrity leading to inhibition of cell motility, induction of apoptosis, and ultimately inhibition of tumor growth...
  19. doi Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma
    Guichun Huang
    Medical Oncology Department of Jinling Hospital, Medical School of Nanjing University, 305 ZhongShan Eastern Road, Nanjing, 210002, People s Republic of China
    J Cancer Res Clin Oncol 136:1201-11. 2010
    ....
  20. ncbi A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma
    P Iughetti
    Centro de Estudos do Genoma Humano, Departamento de Biologia, Instituto de Biociencias, USP, Sao Paulo 05508 900, Brasil
    Cancer Res 61:7375-8. 2001
    ....
  21. ncbi Talc mediates angiostasis in malignant pleural effusions via endostatin induction
    N Nasreen
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine, University of Florida, Gainesville, FL, USA
    Eur Respir J 29:761-9. 2007
    ..Functional improvement following talc poudrage in patients with malignant pleural effusions may, in part, reflect these alterations in the pleural space...
  22. ncbi Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model
    O Kisker
    Division of Surgical Research, Children's Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 61:7669-74. 2001
    ..On the basis of this approach, an additional clinical trial has been designed and initiated and is under way in two countries...
  23. ncbi A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity
    Robert M Tjin Tham Sjin
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:3656-63. 2005
    ..This peptide contains three histidines that are responsible for zinc binding. Mutations of the zinc-binding histidines abolished its antitumor and antimigration activities, but not antipermeability properties...
  24. ncbi Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo
    Wenyin Shi
    Department of Pharmacology and Experimental Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Cancer Gene Ther 9:513-21. 2002
    ..This endostatin level was sufficient to inhibit tumor cell-induced angiogenesis and to suppress both the initiation and subsequent growth of a human colorectal cancer model...
  25. ncbi Endostatin inhibits adhesion of endothelial cells to collagen I via alpha(2)beta(1) integrin, a possible cause of prevention of chondrosarcoma growth
    Takayuki Furumatsu
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, 700 8558, Japan
    J Biochem 131:619-26. 2002
    ..We propose here that endostatin might be effective for anti-angiogenic therapy for human chondrosarcomas through the suppression of alpha(2)beta(1) integrin functions in endothelial cells...
  26. ncbi Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model
    Li Ju Lai
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, 333, Taiwan
    J Biomed Sci 14:313-22. 2007
    ..We concluded that the rAAV was capable of directly delivering genes to the ocular surface epithelium by way of subconjunctival injection and was able to deliver sustained, high levels of gene expression in vivo to inhibit angiogenesis...
  27. ncbi Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor
    Selvarangan Ponnazhagan
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 64:1781-7. 2004
    ....
  28. doi Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo
    Christina Bendrik
    Linkoping University, Department of Clinical and Experimental Medicine, Division of Oncology, University Hospital, Linkoping, Sweden
    Cancer Res 68:3405-12. 2008
    ..This is the first report showing that overexpression of MMP-9 results in increased generation of antiangiogenic fragments, decreased angiogenesis, and therapeutic effects of established breast cancer...
  29. ncbi High level expression of human endostatin in Pichia pastoris using a synthetic gene construct
    Zhijian Su
    School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou, 325035, China
    Appl Microbiol Biotechnol 73:1355-62. 2007
    ..pastoris using artificial synthetic gene of preference in P. pastoris was able to inhibit the acidic fibroblast growth factor-induced proliferation of endothelial cells in vitro...
  30. pmc Endostatin is a potential inhibitor of Wnt signaling
    Jun Ichi Hanai
    Department of Medicine and Center for Study of the Tumor Microenvironment, Division of Nephrology, Hematology Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:529-39. 2002
    ....
  31. ncbi Angiogenesis and tumor metastasis
    B R Zetter
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Med 49:407-24. 1998
    ..Such agents may have reduced toxicity and be less likely to generate drug resistance than conventional cytotoxic drugs. Clinical trials are now underway to develop optimum treatment strategies for antiangiogenic agents...
  32. ncbi Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily
    Joseph P Eder
    Division of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 20:3772-84. 2002
    ..To perform a phase I trial of recombinant human endostatin (rhEndostatin; EntreMed, Rockville, MD) given as a daily 20-minute intravenous (IV) injection in adult patients with refractory solid tumors...
  33. doi A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of paclitaxel-carboplatin alone or with endostar for advanced non-small cell lung cancer
    Baohui Han
    Shanghai Chest Hospital, Shanghai, China
    J Thorac Oncol 6:1104-9. 2011
    ..This study is to explore the clinical efficacy of endostar plus paclitaxel-carboplatin (TC) in advanced NSCLC patients...
  34. ncbi Radiation-enhanced endostatin gene expression and effects of combination treatment
    Xian Luo
    Department of Radiation Medicine, Chan Shun Pavilion, Room A 1010, 11175 Campus Street, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Technol Cancer Res Treat 4:193-202. 2005
    ..05 or less compared to all other groups). No toxicity was observed. These findings are very promising and suggest that endostatin therapy with a plasmid vector, such as pXLG-mEndo, may enhance the efficacy of radiotherapy for lung cancer...
  35. pmc Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation
    Neel R Sodha
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 296:H428-34. 2009
    ..These findings offer potential new therapeutic targets for enhancing proangiogenic therapy and insight into the angiogenic impairments seen in diabetes...
  36. ncbi Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin
    Roy S Herbst
    Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:3804-14. 2002
    ..We present the initial results of a dose-finding clinical trial of recombinant human endostatin (rh-Endo) that examined potential surrogates for response to antiangiogenic therapy...
  37. ncbi Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells
    Sara A Wickström
    Department of Pathology, Haartman Institute and University of Helsinki, Helsinki, Finland
    Cancer Res 62:5580-9. 2002
    ..In addition, the antimigratory effect of endostatin involves phosphatase-dependent Src activation and impaired cell-matrix interactions...
  38. ncbi A prospective analysis of plasma endostatin levels in colorectal cancer patients with liver metastases
    A L Feldman
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Surg Oncol 8:741-5. 2001
    ..Elevated endostatin levels during follow-up are associated with disease progression. Understanding the role of endogenous endostatin in cancer patients may lead to novel strategies to inhibit tumor angiogenesis...
  39. doi Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells
    Na Lu
    Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 210009 Nanjing, People s Republic of China
    Exp Biol Med (Maywood) 233:1013-20. 2008
    ..Additionally, endostar exerted an inhibitory effect on the phosphorylation of ERK1/2. Collectively, these data provided a molecular basis for the anti-invasive effects of endostar...
  40. doi Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells
    Wei Zhuo
    National Engineering Laboratory for Anti Tumour Protein Therapeutics, Tsinghua University, Beijing, China
    J Pathol 222:249-60. 2010
    ....
  41. ncbi Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells
    S Indraccolo
    IST Viral and Molecular Oncology Section Padova, Padova, Italy
    Gene Ther 9:867-78. 2002
    ..These findings indicate heterogeneity in the therapeutic efficacy of angiostatic molecules delivered by viral vectors and suggest that gene therapy with IFN-alpha(1) and endostatin might be useful for treatment of breast cancer...
  42. ncbi Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia
    Nils Glenjen
    Section for Hematology, Department of Medicine, Haukeland University Hospital and the University of Bergen, Norway
    Int J Cancer 101:86-94. 2002
    ..Our results suggest that intensive chemotherapy can modulate the systemic component of angiogenic regulation in AML patients...
  43. ncbi Endostar, a recently introduced recombinant human endostatin, inhibits proliferation and migration through regulating growth factors, adhesion factors and inflammatory mediators in choroid-retinal endothelial cells
    Wen Xu
    Eye Center, The Second Affiliated Hospital, Medical School, Zhejiang University, 310009, Hangzhou, China
    Mol Biol (Mosk) 44:664-70. 2010
    ..These findings reveal an integrated role of Endostar in the program of retinal vascular control and highlight its significant potential for broad clinical application...
  44. pmc Cellular actions and signaling by endostatin
    Ramani Ramchandran
    Division of Nephrology, Department of Medicine and Center for Study of the Tumor Microenvironment, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Crit Rev Eukaryot Gene Expr 12:175-91. 2002
    ..This review summarizes recent advances in endostatin biology and highlights new results on the cellular and subcellular mechanisms of endostatin action...
  45. ncbi [Short-term therapeutic effect and safety of endostar combined with XELIRI regimen in the treatment of advanced colorectal cancer]
    Wang Jun Liao
    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:813-4. 2010
    ..To evaluate the short-term efficacy and toxicity of endostar in combination with XELIRI as the second-line treatment for advanced colorectal cancer...
  46. ncbi Hypoxia-induced increase of endostatin in murine aorta and lung
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Justus Liebig University, 35385, Giessen, Germany
    Histochem Cell Biol 125:497-508. 2006
    ..The surprising finding of increased endostatin in the lung presumably contributes to the development of pulmonary hypertension by reduction of angiogenesis...
  47. doi A randomized phase II study of recombinant human endostatin plus gemcitabine/cisplatin compared with gemcitabine/cisplatin alone as first-line therapy in advanced non-small-cell lung cancer
    Xin Zhao
    The Department of Medical Oncology, Sichuan Cancer Hospital, No 55, Ren Min Nan Road, Chengdu, Sichuan, 610041, China
    Invest New Drugs 30:1144-9. 2012
    ..This study assessed the efficacy of the combination of standard gemcitabine plus cisplatin chemotherapy with rh-endostatin in patients with non-small-cell lung cancer (NSCLC)...
  48. doi Endostar, a recombined humanized endostatin, inhibits lymphangiogenesis and lymphatic metastasis of Lewis lung carcinoma xenograft in mice
    X Dong
    Department of Thoracic Surgery, Second Hospital of Shandong University, Jinan, China
    Thorac Cardiovasc Surg 59:133-6. 2011
    ..The aim of this study was to investigate the effects of Endostar, a recombined humanized endostatin, on lymphatic tumor growth, lymphangiogenesis and lymphatic metastasis of Lewis lung carcinoma (LLC) xenograft in mice...
  49. ncbi Endostar combined with chemotherapy for treatment of metastatic colorectal and gastric cancer: a pilot study
    Jian Feng Zhou
    Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Chin Med J (Engl) 124:4299-303. 2011
    ..This pilot study aimed to evaluate the efficacy and safety of the combination of Endostar and chemotherapy in patients with metastatic colorectal and gastric cancers...
  50. ncbi [Intravenous delivery of cationic liposomes conjugation to recombinant adenoviral vectors containing human endostatin gene inhibits ovarian cancer growth in nude mice]
    Li Wang
    Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:190-4. 2009
    ..To evaluate the anticancer effect of liposome plus Ad-Endostatin complex on human ovarian serous cystocarcinoma...
  51. ncbi A polymorphism in the angiogenesis inhibitor, endostatin, in sporadic colorectal adenocarcinoma
    Helvia Nascimento
    Int J Colorectal Dis 19:499-501. 2004
  52. ncbi Assocation of endostatin D104N with leukemia
    Ta Chih Liu
    Division of Hemato Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 19:1-5. 2003
    ..No patients were homozygous 4349A. Similar frequencies of endostatin polymorphisms were observed in leukemic patients and normal controls. This suggests that the endostatin polymorphism is not associated with the risk of leukemia...
  53. ncbi Endostatin gene therapy for liver cancer by a recombinant adenovirus delivery
    Li Li
    Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China
    World J Gastroenterol 10:1867-71. 2004
    ..To investigate the expression of adenovirus-mediated human endostatin (Ad/hEndo) gene transfer and its effect on the growth of hepatocellular carcinoma (HCC) BEL-7402 xenografted tumors...
  54. ncbi Endostatin exhibits a direct antitumor effect in addition to its antiangiogenic activity in colon cancer cells
    Fatima Dkhissi
    U553 INSERM, Institut d Hematologie, Universite Paris 7, Hopital Saint Louis, 75475 Paris Cedex 10, France
    Hum Gene Ther 14:997-1008. 2003
    ..Thus, endostatin could be used in some colon cancer treatments and its clinical efficacy would depend on the response of tumor cells themselves...
  55. ncbi [Therapeutic features of endostar, a modified endostatin, on ascites tumor in mice]
    Hong Mei Wei
    Postdoctoral Workstation, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1509-13. 2010
    ..To investigate the effect of endostar in controlling ascites tumor formation in mice...
  56. ncbi A polymorphism in the angiogenesis inhibitor, endostatin, in multiple myeloma
    Manoela M Ortega
    Leuk Res 27:93-4. 2003
  57. ncbi Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus
    R Yamanaka
    Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Gene Ther 8:796-802. 2001
    ..The results indicated that treatment with SFV-Endostatin inhibited the angiogenesis with established tumors. Gene therapy with Endostatin delivered via SFV may be a candidate for the development of new therapy for brain tumors...
  58. doi Therapeutic effects of recombinant human endostatin adenovirus in a mouse model of malignant pleural effusion
    Fang Fang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, 610041 Chengdu, People s Republic of China
    J Cancer Res Clin Oncol 135:1149-57. 2009
    ..The present study was designed to test whether the recombinant adenovirus-mediated delivery of human endostatin (Ad-hEndo), one of the potent inhibitors of angiogenesis, would inhibit the formation and progression of MPE...
  59. ncbi Retroviral endostatin gene transfer inhibits human colon cancer cell growth in vivo
    Weichang Chen
    Chin Med J (Engl) 116:1582-4. 2003
    ..To investigate the therapeutic effect of retroviral endostatin gene transfer on the human colon cancer cell line, LoVo...
  60. ncbi Effect of retroviral endostatin gene transfer on subcutaneous and intraperitoneal growth of murine tumors
    A L Feldman
    Surgical Metabolism Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 93:1014-20. 2001
    ..Further studies of retroviral endostatin gene transfer for the treatment of cancer are warranted...
  61. ncbi Addition of integrin binding sequence to a mutant human endostatin improves inhibition of tumor growth
    Yumi Yokoyama
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 111:839-48. 2004
    ..These studies demonstrate that addition of a vascular targeting sequence can enhance the biologic activity of an antiangiogenic molecule...
  62. doi Recombinant human endostatin-associated acute left heart failure
    Q Jing
    Clin Oncol (R Coll Radiol) 20:268. 2008
  63. ncbi The synergistic effect of recombinant human endostatin (YH-16) combined with oxaliplatin on human colorectal carcinoma
    D W Zhang
    Department of General Surgery, Harbin Medical University, Harbin, China
    J Int Med Res 38:111-26. 2010
    ..No obvious change in side-effects occurred. In conclusion, YH-16 combined with L-OHP inhibited growth and induced apoptosis in orthotopically-transplanted human colorectal carcinoma in nude mice without increasing side-effects...
  64. ncbi Serum endostatin levels are elevated in patients with soft tissue sarcoma
    A L Feldman
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer 91:1525-9. 2001
    ..Elevated endostatin levels appear to be associated with tumor aggressiveness. The role of these cytokines in sarcoma angiogenesis and as potential targets for therapy warrants further study...
  65. ncbi Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer
    Gabriella Ferrandina
    Gynecologic Oncology Unit, Department of Histology, Catholic University of Rome, Rome, Italy
    Clin Cancer Res 12:2055-60. 2006
    ..Circulating levels of cytokines [interleukin (IL)-1beta, IL-10, tumor necrosis factor-alpha, IL-6, and IL-12] and angiogenesis-modulating factors (vascular endothelial growth factor and endostatin) have also been analyzed...
  66. ncbi Targeting cyclooxygenase-2 in recurrent non-small cell lung cancer: a phase II trial of celecoxib and docetaxel
    Ildiko Csiki
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Clin Cancer Res 11:6634-40. 2005
    ..However, in light of the apparent survival prolongation in the subset with a marked decline in urinary PGE-M levels, further investigation of strategies designed to decrease PGE(2) synthesis in NSCLC seems warranted...
  67. ncbi Continuous versus intermittent administration of human endostatin in xenografted human neuroblastoma
    Minoru Kuroiwa
    Department of Surgery, Gunma Children s Medical Center, Gunma, Japan
    J Pediatr Surg 38:1499-505. 2003
    ....
  68. doi Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model
    Jinhui Wu
    State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
    J Control Release 134:91-7. 2009
    ..These results indicated PLGA microspheres further reduced the amount of endostatin needed to achieve significant tumor inhibition in mice when compared with systemic administration...
  69. ncbi Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin
    Xiang Ping Li
    Department of Chemistry, 8 F Kadoorie Biological Science Building, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mol Cancer Ther 5:1290-8. 2006
    ..The potent inhibition of NPC metastasis suggests the feasibility of combining rAAV-hEndo gene therapy with other therapies for the prevention and treatment of NPC metastasis...
  70. doi Characterization of a monoPEG20000-Endostar
    Yue Tong
    Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China
    Int J Biol Macromol 46:331-6. 2010
    ..LC/MS was applied to verify the occurrence of mono-PEGylation at the N-terminus of Endostar...
  71. ncbi Experimental inhibition of corneal neovascularization by endostatin gene transfection in vivo
    Ping Zhang
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Chian
    Chin Med J (Engl) 116:1869-74. 2003
    ..To investigate endostatin gene therapy of rat corneal neovascularization induced by acid cauterization...
  72. doi Effect of medium-chain triglycerides on the release behavior of Endostar encapsulated PLGA microspheres
    Boyu Meng
    Jiangsu Simcere Pharmaceutical R and D Co, Ltd, No 699 18 Wuan Wu Avenue, Nanjing 210042, China
    Int J Pharm 397:136-43. 2010
    ....
  73. ncbi Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporation
    Masaya Uesato
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University 1 8 1, Inohana, Chuou ku, Chiba City, Chiba 260 8670, Japan
    Cancer Gene Ther 11:625-32. 2004
    ..These data suggest that in vivo delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination...
  74. ncbi Synergistic activity of recombinant human endostatin in combination with adriamycin: analysis of in vitro activity on endothelial cells and in vivo tumor progression in an orthotopic murine mammary carcinoma model
    Stacy M Plum
    EntreMed, Inc, Rockville, Maryland 20850, USA
    Clin Cancer Res 9:4619-26. 2003
    ..In this study, we determine the antitumor effect of rhEndostatin administered alone or in combination with Adriamycin against established orthotopic murine mammary carcinoma...
  75. ncbi Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
    F A Scappaticci
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    Mol Ther 3:186-96. 2001
    ..The data also suggest that novel combinations of antiangiogenic factors delivered into tumors require further investigation as therapeutic modalities...
  76. ncbi Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C
    Y Lin
    Biocenter Oulu and Department of Biochemistry, University of Oulu, Linnanmaa, FIN 90570 Oulu, Finland
    Development 128:1573-85. 2001
    ..Our data suggest that differential organ morphogenesis is regulated by an intra-organ patterning process that involves coordination between inductive signals and matrix molecules, such as type XVIII collagen...
  77. ncbi Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma
    John R Ohlfest
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:778-88. 2005
    ..We show that SB can be used to increase animal survival significantly (P = 0.008) by combinatorial antiangiogenic gene transfer in an intracranial glioma model...
  78. ncbi Tumor hepatocytes and basement membrane-Producing cells specifically express two different forms of the endostatin precursor, collagen XVIII, in human liver cancers
    O Musso
    INSERM U-456, Detoxication and Tissue Repair Unit, Rennes I University, Rennes, France
    Hepatology 33:868-76. 2001
    ....
  79. ncbi Corneal neovascularization
    J H Chang
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 12:242-9. 2001
    ..quot;..
  80. pmc Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation
    Sanyuan Hu
    Xiangya School of Medicine, Central South University, Changsha, Hunan Province, People s Republic of China
    Int J Nanomedicine 5:1039-48. 2010
    ..Endostar-loaded PEG-PLGA nanoparticles seem to have a better anticancer effect than conventional endostar. We believe that PEG-PLGA nanoparticles are an effective carrier for protein medicines...
  81. pmc Secreted cathepsin L generates endostatin from collagen XVIII
    U Felbor
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 19:1187-94. 2000
    ..We propose that cleavage within collagen XVIII's protease-sensitive region evolved to regulate excessive proteolysis in conditions of induced angiogenesis...
  82. ncbi Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13
    Pia Nyberg
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, FIN 90014 Oulu, Finland
    J Biol Chem 278:22404-11. 2003
    ..Our results also suggest that endostatin inhibits tumor progression by directly affecting the tumor cells and not just acting via endothelial cells and blockage of angiogenesis...
  83. pmc Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    Oliver Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland
    Arthritis Res 4:R11. 2002
    ..VEGF appears to be protective against ischemic manifestations when concentrations of VEGF exceed a certain threshold level...
  84. ncbi Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors
    Matthew H Kulke
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:3555-61. 2006
    ..We therefore performed a multicenter phase II study of rhEndostatin in patients with carcinoid or pancreatic neuroendocrine tumors...
  85. pmc Early endostatin treatment inhibits metastatic seeding of murine colorectal cancer cells in the liver and their adhesion to endothelial cells
    E A te Velde
    Department of Surgery, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Br J Cancer 92:729-35. 2005
    ..Such insights may be helpful in the design of trials to improve (surgical) treatment of colorectal carcinoma and liver metastases...
  86. ncbi Local endostatin treatment of gliomas administered by microencapsulated producer cells
    T A Read
    Department of Anatomy and Cell Biology, University of Bergen, Norway
    Nat Biotechnol 19:29-34. 2001
    ..The present work may thus provide the basis for new therapeutic approaches toward brain tumors...
  87. ncbi Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis
    Guoyong Yin
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Mol Ther 5:547-54. 2002
    ..These data suggest a novel mechanism by which endostatin inhibits angiogenesis, and demonstrates the potential utility of anti-angiogenic gene therapy for treatment of inflammatory arthritis...
  88. ncbi The minimal active domain of endostatin is a heparin-binding motif that mediates inhibition of tumor vascularization
    Anna Karin Olsson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 64:9012-7. 2004
    ..Substitution of arginine residues 193/194 for alanine attenuates the antiangiogenic effects of the peptide. These data show an essential role for heparin binding in the antiangiogenic action of endostatin...
  89. pmc Interaction of endostatin with integrins implicated in angiogenesis
    M Rehn
    Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1024-9. 2001
    ..Taken together, these results implicate integrins as potential targets for endostatin function and support the importance of integrins in endothelial cell biology and angiogenesis...
  90. ncbi Corneal transduction to inhibit angiogenesis and graft failure
    Raghu C Murthy
    Clayton Gene Therapy Laboratory, Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 44:1837-42. 2003
    ..To test whether lentivirus-mediated expression of an endostatin::kringle-5 (E::K-5) fusion gene has an inhibitory effect on neovascularization and failure of corneal transplants...
  91. ncbi Elevated serum concentrations of the angiogenesis inhibitor endostatin in preeclamptic women
    Kora Hirtenlehner
    Departments of Obstetrics and Gynecology, University of Vienna, Vienna, Austria
    J Soc Gynecol Investig 10:412-7. 2003
    ..The aim of our study was to investigate the concentrations of endostatin, a potent endogenous inhibitor of angiogenesis and endothelial or tumor cell growth, in preeclamptic patients...
  92. ncbi Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    T Boehm
    Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 390:404-7. 1997
    ..An unexpected finding is that repeated cycles of antiangiogenic therapy are followed by prolonged tumour dormancy without further therapy...
  93. ncbi Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases
    Ritva Heljasvaara
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Exp Cell Res 307:292-304. 2005
    ....
  94. ncbi Endostatin's antiangiogenic signaling network
    Amir Abdollahi
    Department of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Cell 13:649-63. 2004
    ..More generally, insights into the nature of genetic networking from the cell biologic and therapeutic perspectives are revealed...
  95. ncbi Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
    Enia Lúcia Coutinho
    Division of Nephrology, Department of Medicine, Universidade Federal de Sao Paulo, SP, Brazil
    FASEB J 21:3153-61. 2007
    ..A second mechanism may also be implied in endostatin-dependent tumor regression, associated with tumor infiltration of leukocytes. Besides its antiangiogenic properties, endostatin may be a promising adjuvant to immunotherapy...
  96. ncbi Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cells
    Ralph F Wilson
    Departments of Oral Maxillofacial Surgery and Pathology and Periodontology, College of Dentistry, Ohio State University, Columbus, Ohio, USA
    Anticancer Res 23:1289-95. 2003
    ..Our data imply that endostatin's clinical efficacy extends beyond angiostatic properties to encompass a direct anti-tumorigenic effect against HNSCC cells...
  97. ncbi Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin
    R Ramchandran
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochem Biophys Res Commun 255:735-9. 1999
    ..A polyclonal antibody raised against endostatin cross-reacted with restin. Systemic administration of restin suppressed the growth of tumors in a xenograft renal carcinoma model...
  98. ncbi Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects
    Amir Abdollahi
    Departments of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Res 63:8890-8. 2003
    ..For future clinical evaluation of the concept, a variety of agents with similar mechanistic properties could be tested...
  99. ncbi Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure
    F H Barnett
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Gene Ther 11:1283-9. 2004
    ..We conclude that intra-arterial injection of plasmids selectively targets therapeutic genes to CNS neoplasms. This method of gene therapy holds promise for the treatment of these highly malignant brain tumors...
  100. ncbi Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin
    Olivier Menzel
    Division of Medical Genetics, University of Geneva Medical School and University Hospital of Geneva, Geneva, Switzerland
    Hum Mutat 23:77-84. 2004
    ..We named the second unmapped locus for Knobloch syndrome KNO2. Mutation analysis excluded COL15A1, a member of the multiplexin collagen subfamily similar to COL18A1, as being responsible for KNO2...
  101. pmc Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    Akulapalli Sudhakar
    Program in Matrix Biology, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:4766-71. 2003
    ..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis...

Research Grants70

  1. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2010
    ..This multidisciplinary study will integrate expertise in nanoscience and basic science that may lead to novel strategies to treat angiogenesis-dependent disorders. ..
  2. Tropomyosin in the antiangiogenic activity of HKa
    Keith McCrae; Fiscal Year: 2007
    ....
  3. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2010
    ....
  4. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Olsen; Fiscal Year: 2009
    ....
  5. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2009
    ..Successful completion of these studies will allow us to initiate phase-1 human clinical trials. ..
  6. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2010
    ..Successful completion of these studies will allow us to initiate phase-1 human clinical trials. ..
  7. Regulation of angiogenic balance by thrombospondin-1
    Olga Volpert; Fiscal Year: 2004
    ..This approach has the potential to steer clinical trials towards their most effective use alone, combined with conventional chemotherapy, and for prevention, to delay progressive growth of the dormant tumors. ..
  8. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
    ..Moreover, these humanized receptors will be expressed from regulated adenoviruses to confer an additional degree of safety as a prelude to eventual clinical use. ..
  9. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  10. ANTI ANGIOGENIC ACTIVITY OF CLEAVED HMW KININOGEN
    Keith McCrae; Fiscal Year: 2004
    ..These studies should provide new information concerning the physiologic regulation of angiogenesis, and may lead to identification of new antiangiogenic agents. ..
  11. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
    ..This study may provide important information on the mechanism of action of a class of angiogenesis inhibitors, information that may prove helpful in designing clinical trials for these compounds. ..
  12. QUANTIFYING EFFECTIVENESS OF ANGIOGENIC INHIBITORS
    Philip Hahnfeldt; Fiscal Year: 2000
    ....
  13. TARGETED DELIVERY OF GENES TO ANGIOGENIC VASCULATURE
    Renata Pasqualini; Fiscal Year: 2004
    ..Given that our peptides also target angiogenic vasculature in the retina, these advances are also likely to extend the potential for neovasculature-specific gene therapy targeting to other diseases involving angiogenesis. ..
  14. Heparin like Glycosaminoglycan Oligosaccharides
    Ram Sasisekharan; Fiscal Year: 2004
    ..Similar technologies for DNA and proteins include things like gene chips that have revolutionized the study of these molecules. We hope advancements, like out technology, will do the same thing for HLGAGs. ..
  15. TUMOR PHYSIOLOGICAL EFFECTS OF ANGIOGENESIS INHIBITION
    William Lee; Fiscal Year: 2002
    ..Favorable and/or antagonistic interactions revealed by these studies can guide their combined clinical use and should elucidate the role of angiogenesis and tumor cell killing in tumor response to radiation therapy. ..
  16. Inflammation, fibrosis and myocardial function in schleroderma
    Dorothee Weihrauch; Fiscal Year: 2009
    ..Based on preliminary data we will use an ApoAl mimetic, D-4F, to improve fibrosis, myocardial function and heart failure. ..
  17. HEPARAN SULFATE PROTEOGLYCANS IN NEURAL DEVELOPMENT
    GREGORY COLE; Fiscal Year: 2002
    ..Finally, we will analyze the role of collagen XVIII in blood vessel formation during CNS development. ..