endostatins

Summary

Summary: Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.

Top Publications

  1. ncbi Regulation of collagen-derived antiangiogenic factors by p53
    Sarah Assadian
    McGill University, McGill Cancer Center, 3655 Promenade Sir William Osler, Montreal, QC, Canada
    Expert Opin Biol Ther 8:941-50. 2008
  2. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
  3. ncbi RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism
    Kim Henriksen
    Nordic Bioscience, Herlev DK 2730, Denmark
    J Biol Chem 278:48745-53. 2003
  4. ncbi Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma
    F Bertolini
    Haematology Oncology, IRCCS European Institute of Oncology, Milan, Italy
    Br J Haematol 106:504-9. 1999
  5. ncbi Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo
    Christina Bendrik
    Linkoping University, Department of Clinical and Experimental Medicine, Division of Oncology, University Hospital, Linkoping, Sweden
    Cancer Res 68:3405-12. 2008
  6. ncbi Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor
    Selvarangan Ponnazhagan
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 64:1781-7. 2004
  7. ncbi Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model
    O Kisker
    Division of Surgical Research, Children's Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 61:7669-74. 2001
  8. ncbi Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo
    Wenyin Shi
    Department of Pharmacology and Experimental Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Cancer Gene Ther 9:513-21. 2002
  9. ncbi Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
    Yun Ling
    Department of Physiology, China Pharmaceutical University, Nanjing 210009, China
    Biochem Biophys Res Commun 361:79-84. 2007
  10. ncbi Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model
    Li Ju Lai
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, 333, Taiwan
    J Biomed Sci 14:313-22. 2007

Research Grants

  1. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2010
  2. Tropomyosin in the antiangiogenic activity of HKa
    Keith McCrae; Fiscal Year: 2007
  3. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2010
  4. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Olsen; Fiscal Year: 2009
  5. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2009
  6. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2010
  7. Regulation of angiogenic balance by thrombospondin-1
    Olga Volpert; Fiscal Year: 2004
  8. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
  9. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
  10. ANTI ANGIOGENIC ACTIVITY OF CLEAVED HMW KININOGEN
    Keith McCrae; Fiscal Year: 2004

Detail Information

Publications234 found, 100 shown here

  1. ncbi Regulation of collagen-derived antiangiogenic factors by p53
    Sarah Assadian
    McGill University, McGill Cancer Center, 3655 Promenade Sir William Osler, Montreal, QC, Canada
    Expert Opin Biol Ther 8:941-50. 2008
    ..This effect is partly mediated by the ability of p53 to increase production of endogenous angiogenesis inhibitors, such as the collagen-derived antiangiogenic factors (CDAFs), endostatin and tumstatin...
  2. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
    ..Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy...
  3. ncbi RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism
    Kim Henriksen
    Nordic Bioscience, Herlev DK 2730, Denmark
    J Biol Chem 278:48745-53. 2003
    ..Taken together, these results show that RANKL and VEGF, in addition to their role in osteoclast differentiation and activation of resorption, are important components of the processes regulating osteoclast chemotaxis...
  4. ncbi Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma
    F Bertolini
    Haematology Oncology, IRCCS European Institute of Oncology, Milan, Italy
    Br J Haematol 106:504-9. 1999
    ..Our data suggest that b-FGF and, particularly, VEGF might be considered prognostic factors in NHL staging and management...
  5. ncbi Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo
    Christina Bendrik
    Linkoping University, Department of Clinical and Experimental Medicine, Division of Oncology, University Hospital, Linkoping, Sweden
    Cancer Res 68:3405-12. 2008
    ..This is the first report showing that overexpression of MMP-9 results in increased generation of antiangiogenic fragments, decreased angiogenesis, and therapeutic effects of established breast cancer...
  6. ncbi Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor
    Selvarangan Ponnazhagan
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 64:1781-7. 2004
    ....
  7. ncbi Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model
    O Kisker
    Division of Surgical Research, Children's Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 61:7669-74. 2001
    ..On the basis of this approach, an additional clinical trial has been designed and initiated and is under way in two countries...
  8. ncbi Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo
    Wenyin Shi
    Department of Pharmacology and Experimental Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Cancer Gene Ther 9:513-21. 2002
    ..This endostatin level was sufficient to inhibit tumor cell-induced angiogenesis and to suppress both the initiation and subsequent growth of a human colorectal cancer model...
  9. ncbi Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
    Yun Ling
    Department of Physiology, China Pharmaceutical University, Nanjing 210009, China
    Biochem Biophys Res Commun 361:79-84. 2007
    ..Collectively, these data indicated the relationship between endostar and VEGF signal pathways and provided a molecular basis for the antiangiogenic effects of endostar...
  10. ncbi Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model
    Li Ju Lai
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, 333, Taiwan
    J Biomed Sci 14:313-22. 2007
    ..We concluded that the rAAV was capable of directly delivering genes to the ocular surface epithelium by way of subconjunctival injection and was able to deliver sustained, high levels of gene expression in vivo to inhibit angiogenesis...
  11. ncbi Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells
    Wei Zhuo
    National Engineering Laboratory for Anti Tumour Protein Therapeutics, Tsinghua University, Beijing, China
    J Pathol 222:249-60. 2010
    ....
  12. ncbi Endostatin inhibits adhesion of endothelial cells to collagen I via alpha(2)beta(1) integrin, a possible cause of prevention of chondrosarcoma growth
    Takayuki Furumatsu
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, 700-8558, Japan
    J Biochem (Tokyo) 131:619-26. 2002
    ..We propose here that endostatin might be effective for anti-angiogenic therapy for human chondrosarcomas through the suppression of alpha(2)beta(1) integrin functions in endothelial cells...
  13. ncbi A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity
    Robert M Tjin Tham Sjin
    Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:3656-63. 2005
    ..This peptide contains three histidines that are responsible for zinc binding. Mutations of the zinc-binding histidines abolished its antitumor and antimigration activities, but not antipermeability properties...
  14. ncbi High level expression of human endostatin in Pichia pastoris using a synthetic gene construct
    Zhijian Su
    School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou, 325035, China
    Appl Microbiol Biotechnol 73:1355-62. 2007
    ..pastoris using artificial synthetic gene of preference in P. pastoris was able to inhibit the acidic fibroblast growth factor-induced proliferation of endothelial cells in vitro...
  15. ncbi Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation
    Sanyuan Hu
    Xiangya School of Medicine, Central South University, Changsha, Hunan Province, People s Republic of China
    Int J Nanomedicine 5:1039-48. 2010
    ..Endostar-loaded PEG-PLGA nanoparticles seem to have a better anticancer effect than conventional endostar. We believe that PEG-PLGA nanoparticles are an effective carrier for protein medicines...
  16. ncbi Generation and degradation of human endostatin proteins by various proteinases
    M Ferreras
    OSTEOPRO and Center for Clinical and Basic Research Herlev Ballerup, Herlev, Denmark
    FEBS Lett 486:247-51. 2000
    ..None correspond to mouse endostatin. However, the efficiencies of these proteinases differed markedly. Some proteinases also proved to degrade endostatin, pointing to another regulatory loop of angiogenesis...
  17. ncbi Endostatin exhibits a direct antitumor effect in addition to its antiangiogenic activity in colon cancer cells
    Fatima Dkhissi
    U553 INSERM, , , , 75475 Paris Cedex 10, France
    Hum Gene Ther 14:997-1008. 2003
    ..Thus, endostatin could be used in some colon cancer treatments and its clinical efficacy would depend on the response of tumor cells themselves...
  18. ncbi Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells
    Sara A Wickström
    Department of Pathology, Haartman Institute and University of Helsinki, Helsinki, Finland
    Cancer Res 62:5580-9. 2002
    ..In addition, the antimigratory effect of endostatin involves phosphatase-dependent Src activation and impaired cell-matrix interactions...
  19. ncbi Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin
    Roy S Herbst
    Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:3804-14. 2002
    ..We present the initial results of a dose-finding clinical trial of recombinant human endostatin (rh-Endo) that examined potential surrogates for response to antiangiogenic therapy...
  20. ncbi Retroviral endostatin gene transfer inhibits human colon cancer cell growth in vivo
    Weichang Chen
    Chin Med J (Engl) 116:1582-4. 2003
    ..01). CONCLUSION: Retroviruses can allow functional expression of the endostatin gene in human colon tumors, showing promise for an antitumor strategy using antiangiogenesis...
  21. ncbi Corneal neovascularization
    J H Chang
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 12:242-9. 2001
    ..quot;..
  22. ncbi Effect of retroviral endostatin gene transfer on subcutaneous and intraperitoneal growth of murine tumors
    A L Feldman
    Surgical Metabolism Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 93:1014-20. 2001
    ..Further studies of retroviral endostatin gene transfer for the treatment of cancer are warranted...
  23. ncbi Addition of integrin binding sequence to a mutant human endostatin improves inhibition of tumor growth
    Yumi Yokoyama
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 111:839-48. 2004
    ..These studies demonstrate that addition of a vascular targeting sequence can enhance the biologic activity of an antiangiogenic molecule...
  24. ncbi Serum endostatin levels are elevated in patients with soft tissue sarcoma
    A L Feldman
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer 91:1525-9. 2001
    ..Elevated endostatin levels appear to be associated with tumor aggressiveness. The role of these cytokines in sarcoma angiogenesis and as potential targets for therapy warrants further study...
  25. ncbi The synergistic effect of recombinant human endostatin (YH-16) combined with oxaliplatin on human colorectal carcinoma
    D W Zhang
    Department of General Surgery, Harbin Medical University, Harbin, China
    J Int Med Res 38:111-26. 2010
    ..No obvious change in side-effects occurred. In conclusion, YH-16 combined with L-OHP inhibited growth and induced apoptosis in orthotopically-transplanted human colorectal carcinoma in nude mice without increasing side-effects...
  26. ncbi Recombinant human endostatin-associated acute left heart failure
    Q Jing
    Clin Oncol (R Coll Radiol) 20:268. 2008
  27. ncbi Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin
    Xiang Ping Li
    Department of Chemistry, 8 F Kadoorie Biological Science Building, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mol Cancer Ther 5:1290-8. 2006
    ..The potent inhibition of NPC metastasis suggests the feasibility of combining rAAV-hEndo gene therapy with other therapies for the prevention and treatment of NPC metastasis...
  28. ncbi A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of paclitaxel-carboplatin alone or with endostar for advanced non-small cell lung cancer
    Baohui Han
    Shanghai Chest Hospital, Shanghai, China
    J Thorac Oncol 6:1104-9. 2011
    ..This study is to explore the clinical efficacy of endostar plus paclitaxel-carboplatin (TC) in advanced NSCLC patients...
  29. ncbi Continuous versus intermittent administration of human endostatin in xenografted human neuroblastoma
    Minoru Kuroiwa
    Department of Surgery, Gunma Children's Medical Center, Gunma, Japan
    J Pediatr Surg 38:1499-505. 2003
    ..This indicates that rhEndostatin, if administered in continuous fashion, could become an effective agent for treating patients with neuroblastoma in the future...
  30. ncbi Targeting cyclooxygenase-2 in recurrent non-small cell lung cancer: a phase II trial of celecoxib and docetaxel
    Ildiko Csiki
    Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA
    Clin Cancer Res 11:6634-40. 2005
    ..However, in light of the apparent survival prolongation in the subset with a marked decline in urinary PGE-M levels, further investigation of strategies designed to decrease PGE(2) synthesis in NSCLC seems warranted...
  31. ncbi Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer
    Gabriella Ferrandina
    Gynecologic Oncology Unit, Department of Histology, Catholic University of Rome, Rome, Italy
    Clin Cancer Res 12:2055-60. 2006
    ..Circulating levels of cytokines [interleukin (IL)-1beta, IL-10, tumor necrosis factor-alpha, IL-6, and IL-12] and angiogenesis-modulating factors (vascular endothelial growth factor and endostatin) have also been analyzed...
  32. ncbi Experimental inhibition of corneal neovascularization by endostatin gene transfection in vivo
    Ping Zhang
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Chian
    Chin Med J (Engl) 116:1869-74. 2003
    ..To investigate endostatin gene therapy of rat corneal neovascularization induced by acid cauterization...
  33. ncbi Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporation
    Masaya Uesato
    Department of Academic Surgery (M9, Graduate School of Medicine, Chiba University 1-8-1, Inohana, Chuou-ku, Chiba-city, Chiba 260-8670, Japan
    Cancer Gene Ther 11:625-32. 2004
    ..These data suggest that in vivo delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination...
  34. ncbi Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors
    G Perletti
    Dipartimento di Biologia Strutturale e Funzionale, Universita degli Studi dell Insubria, Varese, Italy
    Cancer Res 60:1793-6. 2000
    ..It not only stops the growth of existing tumors but also decreases the incidence of the development of multiple neoplastic lesions...
  35. ncbi Effect of medium-chain triglycerides on the release behavior of Endostar encapsulated PLGA microspheres
    Boyu Meng
    Jiangsu Simcere Pharmaceutical R and D Co, Ltd, No 699 18 Wuan Wu Avenue, Nanjing 210042, China
    Int J Pharm 397:136-43. 2010
    ....
  36. ncbi Characterization of a monoPEG20000-Endostar
    Yue Tong
    Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China
    Int J Biol Macromol 46:331-6. 2010
    ..LC/MS was applied to verify the occurrence of mono-PEGylation at the N-terminus of Endostar...
  37. ncbi Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model
    Jinhui Wu
    State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
    J Control Release 134:91-7. 2009
    ..These results indicated PLGA microspheres further reduced the amount of endostatin needed to achieve significant tumor inhibition in mice when compared with systemic administration...
  38. ncbi Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
    F A Scappaticci
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    Mol Ther 3:186-96. 2001
    ..The data also suggest that novel combinations of antiangiogenic factors delivered into tumors require further investigation as therapeutic modalities...
  39. ncbi Synergistic activity of recombinant human endostatin in combination with adriamycin: analysis of in vitro activity on endothelial cells and in vivo tumor progression in an orthotopic murine mammary carcinoma model
    Stacy M Plum
    EntreMed, Inc, Rockville, Maryland 20850, USA
    Clin Cancer Res 9:4619-26. 2003
    ..In this study, we determine the antitumor effect of rhEndostatin administered alone or in combination with Adriamycin against established orthotopic murine mammary carcinoma...
  40. ncbi Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C
    Y Lin
    Biocenter Oulu and Department of Biochemistry, University of Oulu, Linnanmaa, FIN 90570 Oulu, Finland
    Development 128:1573-85. 2001
    ..Our data suggest that differential organ morphogenesis is regulated by an intra-organ patterning process that involves coordination between inductive signals and matrix molecules, such as type XVIII collagen...
  41. ncbi Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    Oliver Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland
    Arthritis Res 4:R11. 2002
    ..VEGF appears to be protective against ischemic manifestations when concentrations of VEGF exceed a certain threshold level...
  42. ncbi The minimal active domain of endostatin is a heparin-binding motif that mediates inhibition of tumor vascularization
    Anna Karin Olsson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 64:9012-7. 2004
    ..Substitution of arginine residues 193/194 for alanine attenuates the antiangiogenic effects of the peptide. These data show an essential role for heparin binding in the antiangiogenic action of endostatin...
  43. ncbi Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis
    Guoyong Yin
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Mol Ther 5:547-54. 2002
    ..These data suggest a novel mechanism by which endostatin inhibits angiogenesis, and demonstrates the potential utility of anti-angiogenic gene therapy for treatment of inflammatory arthritis...
  44. ncbi Local endostatin treatment of gliomas administered by microencapsulated producer cells
    T A Read
    Department of Anatomy and Cell Biology, University of Bergen, Norway
    Nat Biotechnol 19:29-34. 2001
    ..The present work may thus provide the basis for new therapeutic approaches toward brain tumors...
  45. ncbi Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors
    Matthew H Kulke
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:3555-61. 2006
    ..We therefore performed a multicenter phase II study of rhEndostatin in patients with carcinoid or pancreatic neuroendocrine tumors...
  46. ncbi Early endostatin treatment inhibits metastatic seeding of murine colorectal cancer cells in the liver and their adhesion to endothelial cells
    E A te Velde
    Department of Surgery, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Br J Cancer 92:729-35. 2005
    ..Such insights may be helpful in the design of trials to improve (surgical) treatment of colorectal carcinoma and liver metastases...
  47. ncbi Tumor hepatocytes and basement membrane-Producing cells specifically express two different forms of the endostatin precursor, collagen XVIII, in human liver cancers
    O Musso
    INSERM U-456, Detoxication and Tissue Repair Unit, Rennes I University, Rennes, France
    Hepatology 33:868-76. 2001
    ....
  48. ncbi Opposite effects of endostatin on different endothelial cells
    Annette Schmidt
    Department of Molecular and Cellular Sport Medicine, German Sport University, Carl-Diem-Weg 6, Cologne 50933, Germany
    Cancer Biol Ther 3:1162-6; discussion 1167-8. 2004
    ..Furthermore the cell biological response at lower concentration on angiogenic eESC gives evidence for an angiogenic modulatory rather than a predicted anti-angiogenic role of endostatin...
  49. ncbi Pharmacokinetics of His-tag recombinant human endostatin in Rhesus monkeys
    Hai feng Song
    Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Acta Pharmacol Sin 26:124-8. 2005
    ..To study the pharmacokinetics and accumulation of an Escherichia coli expressed His-tag fused recombinant human endostatin (rh-endostatin) in Rhesus monkeys...
  50. ncbi Corneal transduction to inhibit angiogenesis and graft failure
    Raghu C Murthy
    Clayton Gene Therapy Laboratory, Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 44:1837-42. 2003
    ..E::K-5 gene transduction through a lentiviral vector system may be a useful adjunct to prevent graft neovascularization and corneal graft rejection in high-risk corneal transplants with antecedent rejection or neovascularization...
  51. ncbi Elevated serum concentrations of the angiogenesis inhibitor endostatin in preeclamptic women
    Kora Hirtenlehner
    Departments of Obstetrics and Gynecology, University of Vienna, Vienna, Austria
    J Soc Gynecol Investig 10:412-7. 2003
    ..The aim of our study was to investigate the concentrations of endostatin, a potent endogenous inhibitor of angiogenesis and endothelial or tumor cell growth, in preeclamptic patients...
  52. ncbi The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
    Amin Hajitou
    Laboratory of Tumor and Development Biology, and, Laboratory of Connective Tissues Biology, , Sart-Tilman, , Belgium
    FASEB J 16:1802-4. 2002
    ..This work provides evidence that endostatin and angiostatin act on tumor cells themselves...
  53. ncbi Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cells
    Ralph F Wilson
    Departments of Oral Maxillofacial Surgery and Pathology and Periodontology, College of Dentistry, Ohio State University, Columbus, Ohio, USA
    Anticancer Res 23:1289-95. 2003
    ..Our data imply that endostatin's clinical efficacy extends beyond angiostatic properties to encompass a direct anti-tumorigenic effect against HNSCC cells...
  54. ncbi Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure
    F H Barnett
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Gene Ther 11:1283-9. 2004
    ..We conclude that intra-arterial injection of plasmids selectively targets therapeutic genes to CNS neoplasms. This method of gene therapy holds promise for the treatment of these highly malignant brain tumors...
  55. ncbi Endostatin's antiangiogenic signaling network
    Amir Abdollahi
    Department of Radiation Oncology, German Cancer Research Center (DKFZ, Heidelberg, Germany
    Mol Cell 13:649-63. 2004
    ..More generally, insights into the nature of genetic networking from the cell biologic and therapeutic perspectives are revealed...
  56. ncbi A polymorphism in the angiogenesis inhibitor, endostatin, in multiple myeloma
    Manoela M Ortega
    Leuk Res 27:93-4. 2003
  57. ncbi Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin
    Olivier Menzel
    Division of Medical Genetics, University of Geneva Medical School and University Hospital of Geneva, Geneva, Switzerland
    Hum Mutat 23:77-84. 2004
    ..We named the second unmapped locus for Knobloch syndrome KNO2. Mutation analysis excluded COL15A1, a member of the multiplexin collagen subfamily similar to COL18A1, as being responsible for KNO2...
  58. ncbi Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects
    Amir Abdollahi
    Departments of Radiation Oncology, German Cancer Research Center (DKFZ, Heidelberg, Germany
    Cancer Res 63:8890-8. 2003
    ..For future clinical evaluation of the concept, a variety of agents with similar mechanistic properties could be tested...
  59. ncbi Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    Akulapalli Sudhakar
    Program in Matrix Biology, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:4766-71. 2003
    ..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis...
  60. ncbi Matrilysin cleavage of corneal collagen type XVIII NC1 domain and generation of a 28-kDa fragment
    H C Lin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and the Schepens Eye Research Institute, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 42:2517-24. 2001
    ..CONCLUSIONS: Collagen XVIII is present in human cornea. MMP-7 cleaves the collagen XVIII NC1 domain to generate a 28-kDa fragment in the cornea...
  61. ncbi Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases
    Ritva Heljasvaara
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Exp Cell Res 307:292-304. 2005
    ....
  62. ncbi N-terminal modification increases the stability of the recombinant human endostatin in vitro
    Li Ping Jiang
    Jiangsu Simcere Pharmaceutical R and D Co, Ltd, 699 18 Xuan Wu Avenue, Nanjing 210042, People s Republic of China
    Biotechnol Appl Biochem 54:113-20. 2009
    ..In the proliferation assay with human umbilical-vein endothelial cells, the zinc-binding and zinc-free endostar samples with extra zinc-binding sites displayed similar inhibiting activities...
  63. ncbi Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells
    T A Read
    Department of Anatomy and Cell Biology, University of Bergen, 5009 Bergen, Norway
    Cancer Res 61:6830-7. 2001
    ..Finally, this work further confirms the new therapeutic concept using alginate cell-encapsulation technology for the localized delivery of therapeutic compounds to central nervous system malignancies...
  64. ncbi Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells
    S A Wickström
    Cell Biology and Molecular Cancer Biology Laboratories, Biomedicum Helsinki, University of Helsinki, FIN 00014 Helsinki, Finland
    Cancer Res 61:6511-6. 2001
    ..Our results suggest that the antiangiogenic activity of endostatin involves the modulation of focal adhesions and actin stress fibers and the down-regulation of the urokinase plasminogen activator system...
  65. ncbi Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells
    Huaining Teng
    Institute of Biochemistry and Cell Biology, Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 39:278-84. 2007
    ..These results widen the clinical application of the microencapsulated cell endostatin delivery system in cancer treatment...
  66. ncbi Endostatin regulates endothelial cell adhesion and cytoskeletal organization
    Johan Dixelius
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden
    Cancer Res 62:1944-7. 2002
    ..These data provide a molecular basis both for the lack of effect of endostatin on the normal, quiescent vasculature, and its antagonistic effects on stimulated tumor vessels...
  67. ncbi Optimization of microencapsulated recombinant CHO cell growth, endostatin production, and stability of microcapsule in vivo
    Ying Zhang
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese, Academy of Sciences, Dalian 116023, People s Republic of China
    J Biomed Mater Res B Appl Biomater 84:79-88. 2008
    ..The optimized microencapsulation conditions for in vivo implantation are liquid core and 240 microm in diameter. This study provides useful information for antiangiogenic gene therapy to tumors using microencapsulated recombinant cells...
  68. ncbi Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
    Enia Lúcia Coutinho
    Division of Nephrology, Department of Medicine, Universidade Federal de Sao Paulo, SP, Brazil
    FASEB J 21:3153-61. 2007
    ..A second mechanism may also be implied in endostatin-dependent tumor regression, associated with tumor infiltration of leukocytes. Besides its antiangiogenic properties, endostatin may be a promising adjuvant to immunotherapy...
  69. ncbi Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin
    Xuefeng Zhang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 13:3968-76. 2007
    ..We aimed to develop rAAV-mediated antiangiogenic gene therapy delivering endostatin and 3TSR, the antiangiogenic domain of thrombospondin-1...
  70. ncbi Endostatin gene therapy enhances the efficacy of paclitaxel to suppress breast cancers and metastases in mice
    Jie Li
    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Jinan, China
    J Biomed Sci 15:99-109. 2008
    ..The combinational therapy with endostatin and paclitaxel warrants future investigation as a therapeutic strategy to combat breast cancer...
  71. ncbi Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis
    J Dixelius
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Blood 95:3403-11. 2000
    ..In conclusion, our data show that endostatin induces tyrosine kinase activity and enhanced apoptosis in FGF-treated endothelial cells...
  72. ncbi A high risk of occurrence of sporadic breast cancer in individuals with the 104NN polymorphism of the COL18A1 gene
    Gustavo J Lourenco
    Breast Cancer Res Treat 100:335-8. 2006
    ..Our results suggest, for the first time, that the homozygous 104NN polymorphism, even at low frequency, constitutes an important inherited determinant of the disease...
  73. ncbi Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma
    Dag R Sorensen
    Department of Comparative Medicine, Rikshospitalet, University of Oslo, Norway
    Neuro Oncol 4:1-8. 2002
    ..This work verifies the general anti-angiogenic and antitumor effects of endostatin and indicates that the protein may also be considered as a treatment strategy for malignant brain tumors...
  74. ncbi Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans
    Renata C M Reis
    Department of Histology and Embryology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Biochem Biophys Res Commun 333:976-83. 2005
    ..Taken as a whole, our results demonstrate that there is a direct connection between the dependence of endostatin activity on heparin-like glycosaminoglycans and its ability to antagonize bFGF...
  75. ncbi Endostatin phenylalanines 31 and 34 define a receptor binding site
    Sonja Stahl
    Department of Human Genetics, , Biozentrum, Am Hubland, , Germany
    Genes Cells 10:929-39. 2005
    ..Our data suggest that residues F31 and F34 form a putative receptor binding site acting independently from heparan sulfate binding and that the A48T mutation destabilizes the endostatin molecule...
  76. ncbi Clinical significance of plasma endostatin in acute myeloid leukemia/myelodysplastic syndrome
    Raymond Lai
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    Cancer 94:14-7. 2002
    ..The mechanism underlying the association between high PE and poor clinical outcome is unclear, although it may be related to the possible PE reflection of tumor burden...
  77. ncbi Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1
    Jun Ichi Hanai
    Divisions of Nephrology and Hematology Oncology, Department of Medicine and Center for Study of the Tumor Microenvironment, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:16464-9. 2002
    ..Collectively, our data pointed to a role for cyclin D1, and in particular, transcription through the LEF1 site as critical for endostatin action in vitro and suggest that beta-catenin is a target for endostatin...
  78. ncbi Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    T Boehm
    Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 390:404-7. 1997
    ..An unexpected finding is that repeated cycles of antiangiogenic therapy are followed by prolonged tumour dormancy without further therapy...
  79. ncbi High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours
    T S Zorick
    Center for the Study of the Human Genome, Department of Biology, University of Sao Paulo, Sao Paulo, Brazil
    Eur J Hum Genet 9:811-4. 2001
    ..Based upon these data, we propose that an increase of about one-third of normal endostatin serum levels may represent an effective therapeutic dose to significantly inhibit many solid tumours...
  80. ncbi Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin
    R Ramchandran
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochem Biophys Res Commun 255:735-9. 1999
    ..A polyclonal antibody raised against endostatin cross-reacted with restin. Systemic administration of restin suppressed the growth of tumors in a xenograft renal carcinoma model...
  81. ncbi Interaction of endostatin with integrins implicated in angiogenesis
    M Rehn
    Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1024-9. 2001
    ..Taken together, these results implicate integrins as potential targets for endostatin function and support the importance of integrins in endothelial cell biology and angiogenesis...
  82. ncbi Antiangiogenic activity of a matrix protein
    Judah Folkman
    Harvard Medical School; Children's Hospital; Hunnelwell 103; 300 Longwood Ave.; Boston, Massachusetts 02115-5737, USA
    Cancer Biol Ther 2:53-4. 2003
  83. ncbi Angiogenesis and cancer: recent advances
    William Caceres
    San Juan Veterans Affairs Medical Center, 10 Calle Casia, San Juan, Puerto Rico 00921
    P R Health Sci J 22:149-51. 2003
    ..The use of antiangiogenic agents, both in combination with other treatment modalities in the acute setting as well as long-term maintenance or prevention of cancer, is at present one of the better promises in the war against cancer...
  84. ncbi Angiogenesis as a target for cancer therapy
    Kerim Kaban
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Hematol Oncol Clin North Am 16:1125-71. 2002
    ..Still, there is much to learn about the machinery that tumors use to recruit new blood vessels, and the results of the clinical trials will show the best way to apply that knowledge for cancer therapy...
  85. ncbi Delivery of endostatin in experimental cancer therapy
    Dag R Sorensen
    Department of Comparative Medicine, Rikshospitalet, University of Oslo, Norway
    Int J Exp Pathol 83:265-74. 2002
    ..In this paper we review some of the basic knowledge of endostatin and look specifically into the different possible ways in which endostatin may be administered...
  86. ncbi Studies on the structure-activity relationship of endostatin: synthesis of human endostatin peptides exhibiting potent antiangiogenic activities
    Francesco Chillemi
    Department of Organic and Industrial Chemistry, University of Milan, Via Venezian, 21, 20133 Milano, Italy
    J Med Chem 46:4165-72. 2003
    ..We propose to use the peptides 6-49 and 134-178 as angiogenesis inhibitors in substitution of full length endostatin, in therapeutic applications for cancer, rheumatoid arthritis, and retinopathies...
  87. ncbi Functional characterization of neostatins, the MMP-derived, enzymatic cleavage products of type XVIII collagen
    Jin Hong Chang
    Corneal, External Disease and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary and the Schepens Eye Research Institute, Harvard Medical School, 243 Charles Street, Boston, MA 02114, United States
    FEBS Lett 579:3601-6. 2005
    ..These results provide supportive evidence of the possible anti-angiogenic effect of neostatins...
  88. ncbi Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model
    Sudhanshu P Raikwar
    Department of Urology, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN 46202, USA
    Mol Ther 12:1091-100. 2005
    ..These results suggest that a combinatorial antiangiogenic gene therapy approach involving Ad-hEndo-angio and Ad-sTie2 could become a novel form of treatment for localized human prostate cancer...
  89. ncbi Angiogenic and antiangiogenic balance regulates concomitant antitumoral resistance
    O Graciela Scharovsky
    , School of Medical Sciences, University of Rosario, Rosario, Argentina
    Clin Exp Metastasis 21:177-83. 2004
    ..The levels of the factors involved in this phenomenon can vary in the different tumor models, but the trend favoring the inhibition of angiogenesis is always conserved...
  90. ncbi The clinical potential of antiangiogenic fragments of extracellular matrix proteins
    A R Clamp
    Cancer Research UK Department of Medical Oncology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK
    Br J Cancer 93:967-72. 2005
    ..Lessons learned from these studies will aid the future clinical development of other antiangiogenic extracellular matrix protein fragments...
  91. ncbi p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase
    Jose G Teodoro
    Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Science 313:968-71. 2006
    ..Our results reveal a genetic and biochemical linkage between the p53 tumor suppressor pathway and the synthesis of antiangiogenic collagen fragments...
  92. ncbi A gene transfer comparative study of HSA-conjugated antiangiogenic factors in a transgenic mouse model of metastatic ocular cancer
    E Frau
    CNRS UMR 8121 Univ Paris Sud, Vectorologie et Transfert de Gènes, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Cancer Gene Ther 14:251-61. 2007
    ..Our study indicates that systemic antiangiogenic factors production by recombinant adenoviruses, particularly Can, might represent an effective way of delaying metastatic growth via inhibition of angiogenesis...
  93. ncbi Evidence of efficacy: researchers investigating markers for angiogenesis inhibitors
    Vicki Brower
    J Natl Cancer Inst 95:1425-7. 2003
  94. ncbi [The clinical perspective of angiogenesis inhibitors]
    S A Radema
    Universitair Medisch Centrum Utrecht, afd. Medische Oncologie, Postbus 85.500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 147:1675-80. 2003
    ..Angiogenesis research has contributed to the knowledge of the biology of cancer, the design of modified clinical studies and the development of surrogate markers that can be used as pharmacodynamic end points in future studies...
  95. ncbi [Clinical development of anti-angiogenic agents in 2002]
    Thomas Bachelot
    Unité Cytokines et Cancers, INSERM U453, Centre Leon Berard, 28, rue Laennec, 69373 Lyon Cedex 08
    Bull Cancer 90:19-23. 2003
    ..Further clinical trials are needed to gain clear insight into the precise role of those promising strategies for the management of solid tumours...
  96. ncbi Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways
    Kerstin Eriksson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, S-751 85 Uppsala, Sweden
    FEBS Lett 536:19-24. 2003
    ..We conclude that angiostatin and endostatin inhibit chemotaxis, without affecting intracellular signalling pathways known to regulate endothelial migration and proliferation/survival...
  97. ncbi Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells
    Robert Pawliuk
    Division of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts 02139, USA
    Mol Ther 5:345-51. 2002
    ..Resolution of this paradox may come from human trials of endostatin now underway...
  98. ncbi Adipose tissue mass can be regulated through the vasculature
    Maria A Rupnick
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:10730-5. 2002
    ..We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature...
  99. ncbi Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma
    S Monestiroli
    Division of Hematology-Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Cancer Res 61:4341-4. 2001
    ..Conversely, in mice given endostatin, all of the increase in apoptotic cells was in the endothelial cell compartment. CEC evaluation is promising as a noninvasive, surrogate angiogenesis marker...
  100. ncbi Antiangiogenic and antitumor effects of endostatin on follicular thyroid carcinoma
    Caisheng Ye
    Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-sen University, Guangzhou, Guangdong 510075, China
    Endocrinology 143:3522-8. 2002
    ..By using two different approaches, namely the recombinant endostatin protein and the gene therapy strategy, our study demonstrated that endostatin could be effective in suppressing the growth of human FTC in immunodeficient mice...
  101. ncbi Anticancer treatment of endostatin gene therapy by targeting tumor neovasculature in C57/BL mice
    S Jia
    Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
    Clin Hemorheol Microcirc 23:251-7. 2000
    ..Hence, our results demonstrated the inhibitory effect of ES gene therapy on angiogenesis-dependent tumor growth and metastasis...

Research Grants70

  1. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2010
    ..This multidisciplinary study will integrate expertise in nanoscience and basic science that may lead to novel strategies to treat angiogenesis-dependent disorders. ..
  2. Tropomyosin in the antiangiogenic activity of HKa
    Keith McCrae; Fiscal Year: 2007
    ....
  3. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2010
    ....
  4. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Olsen; Fiscal Year: 2009
    ....
  5. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2009
    ..Successful completion of these studies will allow us to initiate phase-1 human clinical trials. ..
  6. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2010
    ..Successful completion of these studies will allow us to initiate phase-1 human clinical trials. ..
  7. Regulation of angiogenic balance by thrombospondin-1
    Olga Volpert; Fiscal Year: 2004
    ..This approach has the potential to steer clinical trials towards their most effective use alone, combined with conventional chemotherapy, and for prevention, to delay progressive growth of the dormant tumors. ..
  8. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
    ..Moreover, these humanized receptors will be expressed from regulated adenoviruses to confer an additional degree of safety as a prelude to eventual clinical use. ..
  9. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  10. ANTI ANGIOGENIC ACTIVITY OF CLEAVED HMW KININOGEN
    Keith McCrae; Fiscal Year: 2004
    ..These studies should provide new information concerning the physiologic regulation of angiogenesis, and may lead to identification of new antiangiogenic agents. ..
  11. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
    ..This study may provide important information on the mechanism of action of a class of angiogenesis inhibitors, information that may prove helpful in designing clinical trials for these compounds. ..
  12. QUANTIFYING EFFECTIVENESS OF ANGIOGENIC INHIBITORS
    Philip Hahnfeldt; Fiscal Year: 2000
    ....
  13. TARGETED DELIVERY OF GENES TO ANGIOGENIC VASCULATURE
    Renata Pasqualini; Fiscal Year: 2004
    ..Given that our peptides also target angiogenic vasculature in the retina, these advances are also likely to extend the potential for neovasculature-specific gene therapy targeting to other diseases involving angiogenesis. ..
  14. Heparin like Glycosaminoglycan Oligosaccharides
    Ram Sasisekharan; Fiscal Year: 2004
    ..Similar technologies for DNA and proteins include things like gene chips that have revolutionized the study of these molecules. We hope advancements, like out technology, will do the same thing for HLGAGs. ..
  15. TUMOR PHYSIOLOGICAL EFFECTS OF ANGIOGENESIS INHIBITION
    William Lee; Fiscal Year: 2002
    ..Favorable and/or antagonistic interactions revealed by these studies can guide their combined clinical use and should elucidate the role of angiogenesis and tumor cell killing in tumor response to radiation therapy. ..
  16. Inflammation, fibrosis and myocardial function in schleroderma
    Dorothee Weihrauch; Fiscal Year: 2009
    ..Based on preliminary data we will use an ApoAl mimetic, D-4F, to improve fibrosis, myocardial function and heart failure. ..
  17. HEPARAN SULFATE PROTEOGLYCANS IN NEURAL DEVELOPMENT
    GREGORY COLE; Fiscal Year: 2002
    ..Finally, we will analyze the role of collagen XVIII in blood vessel formation during CNS development. ..