angiogenic proteins

Summary

Summary: Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.

Top Publications

  1. pmc MicroRNAs as novel regulators of angiogenesis
    Yajaira Suarez
    Vascular Biology and Therapuetics Program corrected Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Circ Res 104:442-54. 2009
  2. pmc VEGF-B: a survival, or an angiogenic factor?
    Xuri Li
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Adh Migr 3:322-7. 2009
  3. ncbi Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1
    K Oda
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cytogenet Cell Genet 84:75-82. 1999
  4. pmc Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1
    Jayson Hardcastle
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Comprehensive Cancer Center and The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Mol Ther 18:285-94. 2010
  5. ncbi Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators
    A P Hess
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143 0132, USA
    Biol Reprod 76:102-17. 2007
  6. pmc Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 162:19-27. 2003
  7. pmc Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1
    Dan Zhu
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia, USA
    Cancer Res 71:5859-70. 2011
  8. ncbi Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma
    Brian Worden
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892 1419, USA
    Cancer Res 65:7071-80. 2005
  9. ncbi Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma
    Shigetaka Kudo
    Department of Urology, Iwate Medical University School of Medicine, Morioka 020 8505, Japan
    Oncol Rep 18:785-91. 2007
  10. ncbi Tumour interstitial fluid pressure may regulate angiogenic factors in osteosarcoma
    Saminathan S Nathan
    Musculoskeletal Oncology Service, Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 38:1041-7. 2009

Detail Information

Publications226 found, 100 shown here

  1. pmc MicroRNAs as novel regulators of angiogenesis
    Yajaira Suarez
    Vascular Biology and Therapuetics Program corrected Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Circ Res 104:442-54. 2009
    ....
  2. pmc VEGF-B: a survival, or an angiogenic factor?
    Xuri Li
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Adh Migr 3:322-7. 2009
    ....
  3. ncbi Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1
    K Oda
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cytogenet Cell Genet 84:75-82. 1999
    ..As a protein partner of BAI1, BAIAP2 may represent an important link between membrane and cytoskeleton in the process of neuronal growth...
  4. pmc Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1
    Jayson Hardcastle
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Comprehensive Cancer Center and The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Mol Ther 18:285-94. 2010
    ..This is the first study to report the antitumor effects of Vstat120 delivery into established tumors and supports the further development of RAMBO as a possible cancer therapy...
  5. ncbi Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators
    A P Hess
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143 0132, USA
    Biol Reprod 76:102-17. 2007
    ....
  6. pmc Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 162:19-27. 2003
    ..The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit...
  7. pmc Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1
    Dan Zhu
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia, USA
    Cancer Res 71:5859-70. 2011
    ..These findings have therapeutic implications because inhibiting MBD2 could offer a strategy to reactivate BAI1 and suppress glioma pathobiology...
  8. ncbi Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma
    Brian Worden
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892 1419, USA
    Cancer Res 65:7071-80. 2005
    ....
  9. ncbi Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma
    Shigetaka Kudo
    Department of Urology, Iwate Medical University School of Medicine, Morioka 020 8505, Japan
    Oncol Rep 18:785-91. 2007
    ..These observations suggest that the transfer of the BAI1 gene to Renca can suppress the tumor growth via the inhibition of angiogenesis. The down-regulation of VEGF production in tumor cells contributes to this anti-tumor effect...
  10. ncbi Tumour interstitial fluid pressure may regulate angiogenic factors in osteosarcoma
    Saminathan S Nathan
    Musculoskeletal Oncology Service, Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 38:1041-7. 2009
    ..In this study, we hypothesized that constitutively raised IFP in osteosarcomas regulates angiogenesis...
  11. ncbi Lipid-mediated delivery of brain-specific angiogenesis inhibitor 1 gene reduces corneal neovascularization in an in vivo rabbit model
    K C Yoon
    Department of Ophthalmology, Chonnam National University Medical School, Kwangju 501 190, South Korea
    Gene Ther 12:617-24. 2005
    ..These results indicate that BAI1-ECR gene delivery effectively reduces experimental corneal neovascularization and suggest that the BAI1-ECR protein can be used as an angiogenesis suppressor in the eye...
  12. ncbi Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients
    Daniele Santini
    Medical Oncology, Department of Laboratory Medicine, Campus Bio Medico University, 00155 Rome, Italy
    Clin Cancer Res 9:2893-7. 2003
    ..The patients were prospectively evaluated for circulating levels of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) just before and at 1, 2, 7, and 21 days after zoledronic acid infusion...
  13. ncbi Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer
    Y Fukushima
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Int J Oncol 13:967-70. 1998
    ..0003). These observations suggested that BAI1 expression might inhibit angiogenesis and metastasis of colorectal cancer...
  14. pmc Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome
    Xiao Li Tian
    Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA
    Nature 427:640-5. 2004
    ..These results define VG5Q as an angiogenic factor, establish VG5Q as a susceptibility gene for KTS, and show that increased angiogenesis is a molecular pathogenic mechanism of KTS...
  15. pmc Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin
    Philip A Klenotic
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Pathol 176:2039-50. 2010
    ..These data help define a novel angiogenic axis that could be exploited for the treatment of human cancers and other diseases where excess angiogenesis occurs...
  16. pmc Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism
    Balveen Kaur
    Department of Neurosurgery, Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 69:1212-20. 2009
    ..These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies...
  17. ncbi Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance
    Do Hyun Nam
    Department of Neurosurgery, Samsung Medical Center and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul 135 710, Korea
    Oncol Rep 11:863-9. 2004
    ..These findings suggest that the balance between the angiogenic and anti-angiogenic factors is important in the progression of glioblastoma and its response to treatment...
  18. pmc Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis
    D G Duda
    First Department of Surgery, Tohoku University Medical School, 1 1 Seiryomachi, Aoba ku, 980 8574 Sendai, Japan
    Br J Cancer 86:490-6. 2002
    ..Brain-specific angiogenesis inhibitor 1 should be considered for gene therapy and development of efficient drugs based on endogenous antiangiogenic molecules...
  19. ncbi BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
    Daeho Park
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 450:430-4. 2007
    ..Thus, BAI1 is a phosphatidylserine recognition receptor that can directly recruit a Rac-GEF complex to mediate the uptake of apoptotic cells...
  20. ncbi Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects
    Ian Zachary
    Centre for Cardiovascular Biology and Medicine, Department of Cardiovascular Science, Division of Medicine, University College London, London, UK
    Heart 97:181-9. 2011
    ..This review discusses therapeutic angiogenesis in the light of recent scientific advances and clinical evidence, and considers the future challenges and prospects for therapeutic angiogenesis...
  21. pmc Identification of association of common AGGF1 variants with susceptibility for Klippel-Trenaunay syndrome using the structure association program
    Y Hu
    Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Hum Genet 72:636-43. 2008
    ..These results suggest that common AGGF1 variants confer risk of KTS...
  22. ncbi New aspects in the pathophysiology of preeclampsia
    John M Davison
    Franz Volhard Clinic, Wiltberg Strasse 50, 13125 Berlin, Germany
    J Am Soc Nephrol 15:2440-8. 2004
    ..Preeclamptic women also produce novel autoantibodies that may serve to activate angiotensin receptors. These new observations raise the possibility that the treatment of preeclamptic women will soon be improved...
  23. pmc Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function
    Chun Fan
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:23331-43. 2009
    ..These results demonstrate that GATA1 regulates expression of AGGF1 and reveal a novel role for GATA1 in endothelial cell biology and angiogenesis...
  24. ncbi Capillary supply and gene expression of angiogenesis-related factors in murine skeletal muscle following denervation
    A Wagatsuma
    Department of Physiological Sciences, National Institute of Fitness and Sports, Shiromizu cho 1, Kanoya, Kagoshima 891 2393, Japan
    Exp Physiol 90:403-9. 2005
    ..These findings indicate that reduction in the expression of mRNAs in the VEGF/KDR/Flk-1 and Flt-1 as well as angiopoietin-1/Tie-2 signal pathways might be one of the reasons for the capillary regression during chronic denervation...
  25. pmc Biomedicine and diseases: the Klippel-Trenaunay syndrome, vascular anomalies and vascular morphogenesis
    A A Timur
    Center for Molecular Genetics, ND40, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Cell Mol Life Sci 62:1434-47. 2005
    ....
  26. ncbi Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins
    Ramaswamy Bhuvaneswari
    National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610
    Photochem Photobiol Sci 6:1275-83. 2007
    ..b>Angiogenic proteins e.g...
  27. ncbi Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Liver Int 26:414-23. 2006
    ..Angiogenesis is regulated by a balance between pro and antiangiogenic molecules. The aim of this study was to investigate the expressions of angiogenic factors and elucidate their roles in angiogenesis in HCC...
  28. ncbi Angiogenic proteins in brains of patients who died with cerebral malaria
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Str 3, D 72076 Tubingen, Germany
    J Neuroimmunol 142:101-11. 2003
    ..These data demonstrate the activation of the proangiogenic VEGF signaling cascade in patients with CM, probably reflecting compensatory mechanisms of general and focal brain hypoxia observed in these patients...
  29. ncbi Emerging roles of antiangiogenic and angiogenic proteins in pathogenesis and prediction of preeclampsia
    Marshall D Lindheimer
    Hypertension 50:35-6. 2007
  30. ncbi Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease
    Lakshmi Thirumangalakudi
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 10:111-8. 2006
    ....
  31. ncbi Expression profiling of angiogenic genes for the characterisation of colorectal carcinoma
    Alessandro Carrer
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Area Science Park, Trieste, Italy
    Eur J Cancer 44:1761-9. 2008
    ....
  32. ncbi Thrombin activation of endometrial endothelial cells: a possible role in intrauterine growth restriction
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, School of Medicine, New Haven, CT 06520 8063, USA
    Thromb Haemost 97:245-53. 2007
    ..Thus, we postulate that reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes...
  33. ncbi Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Departments of Neurosurgery, Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Oncogene 24:3632-42. 2005
    ..Modulation of this cleavage or delivery of Vasculostatin may constitute novel treatment modalities for cancer and other diseases of aberrant angiogenesis, especially in the brain...
  34. ncbi Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors
    Wenpeng Dong
    Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, Peoples Republic of China
    J Vasc Surg 48:709-14. 2008
    ..This study investigated the effects and possible protective mechanism of resveratrol on the delayed phase after focal cerebral ischemia injury in mice...
  35. pmc Pathophysiology of tumor neovascularization
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Vasc Health Risk Manag 1:277-90. 2005
    ..In addition, recent topics such as contribution of the endothelial progenitor cells, tumor vasculogenic mimicry, markers for tumor-derived endothelial cells and pericytes, and angiogenic/angiostatic chemokines are summarized...
  36. ncbi A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 27:1297-304. 2007
    ..We have investigated the interaction between AHR and hypoxia signaling pathways in regulation of angiogenesis with the use of a surgical model of ischemia...
  37. ncbi Angiogenic expression profile of normal and neurofibromin-deficient human Schwann cells
    Stacey L Thomas
    Research Service, Edward Hines Jr V A Hospital, 5th Avenue and Roosevelt Road, Hines, IL 60141, USA
    Neurochem Res 32:1129-41. 2007
    ..These dysregulated molecules may contribute to the growth and progression of NF1 peripheral nerve sheath tumors...
  38. ncbi Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study
    Angeles Alvarez Secord
    DUMC 3079, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    Gynecol Oncol 106:221-32. 2007
    ....
  39. ncbi Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability
    Nobuki Miyamoto
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Sapporo, Japan
    Cancer Lett 254:42-53. 2007
    ..The difference may be associated with less aggressive phenotype of these cancers with MSI-H and affect future molecular targeted therapeutics...
  40. ncbi Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy
    Anthony P Hall
    AstraZeneca R and D Alderley Park, Safety Assessment UK, Mereside, Alderley Park, Macclesfield, SK10 4TG Cheshire, England
    Toxicol Pathol 34:763-75. 2006
  41. ncbi Clinical progression and familial occurrence of cerebral cavernous angiomas: the role of angiogenic and growth factors
    Francesco Maiuri
    Division of Neurosurgery, Department of Neurological Sciences, Universita degli Studi di Napoli Federico II, Naples, Italy
    Neurosurg Focus 21:e3. 2006
    ..The goal was to define whether the often progressive clinical course of both sporadic and familial forms of the lesion is correlated with different expression of these factors...
  42. ncbi Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis
    Stefano Indraccolo
    Istituto Oncologico Veneto, Padova, Italy
    Cell Cycle 5:1751-5. 2006
    ..Here we discuss the implications of these observations on our view of tumor angiogenesis and on the therapeutic potential of angiogenesis inhibitors...
  43. ncbi Angiogenesis in colorectal cancer: prognostic and therapeutic implications
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Am J Clin Oncol 29:408-17. 2006
    ..It is expected that, in addition to adjuvant chemotherapy and radiotherapy, agents blocking the stimulatory effect of VEGF on endothelial cells would prove beneficial to the patient...
  44. ncbi Minimal model for tumor angiogenesis
    P G Kevrekidis
    Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts 01003 4515, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 73:061926. 2006
    ..We examine the model numerically in two-dimensional settings, discussing its comparison with experimental results...
  45. ncbi Angiogenesis for the treatment of inoperable coronary disease: the future
    Frank W Sellke
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Semin Cardiothorac Vasc Anesth 10:184-8. 2006
    ....
  46. ncbi Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors
    Namali T Fernando
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 14:1529-39. 2008
    ..Thrombospondin-1 (Tsp1), endostatin, and tumstatin are extracellular matrix-associated proteins that inhibit angiogenesis. We examined the mechanisms by which tumor cells may bypass the antiangiogenic effects of these endogenous regulators...
  47. pmc Diversity of the angiogenic phenotype in non-small cell lung cancer
    Marc R McClelland
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 36:343-50. 2007
    ..We conclude that lung cancer tumors evolve a unique and dominant angiogenic phenotype. Once an angiogenic pathway is activated, it may allow for tumor growth to proceed in the absence of a selection pressure to activate a second pathway...
  48. ncbi Expression of angiogenic factors in childhood B-cell precursor acute lymphoblastic leukemia
    Daniel Stachel
    Klinik mit Poliklinik für Kinder und Jugendliche, Friedrich Alexander Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Oncol Rep 17:147-52. 2007
    ..The mRNA expression of iNOS in the surviving children possibly reflects an increased activity of the immune system against the leukemia which leads to a superior survival...
  49. ncbi Angiogenesis--a new target for future therapy
    Nilesh M Pandya
    Department of Pharmacology, C U Shah College of Pharmacy and Research, Wadhwan City 363030, Dist Surendranagar, India
    Vascul Pharmacol 44:265-74. 2006
    ..Substantial evidence also implicates VEGF as an angiogenic mediator in tumors and intraocular neovascular syndromes, and numerous clinical trials are presently testing the hypothesis that inhibition of VEGF may have therapeutic value...
  50. ncbi Photo-crosslinkable and biodegradable Pluronic/heparin hydrogels for local and sustained delivery of angiogenic growth factor
    Jun Jin Yoon
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305 701, South Korea
    J Biomed Mater Res A 83:597-605. 2007
    ..When the Pluronic/heparin hydrogels were implanted in vivo, a significant extent of neo-vascularization was observed...
  51. ncbi Angiogenic growth factors in the treatment of peripheral arterial disease
    Dimitrios Mikroulis
    Department of Cardiothoracic Surgery, Democritus University of Thrace, Greece
    Curr Vasc Pharmacol 5:195-209. 2007
    ..VEGF is important in the pathogenesis of diabetic microvascular disease. Further studies are required before implementation of AGF therapy in clinical practice...
  52. ncbi A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through alpha5beta1 integrin
    Simonetta Soro
    Department of Biochemical Sciences A Rossi Fanelli, University La Sapienza, Rome, Italy
    Blood 111:3479-88. 2008
    ..Alanine scanning mutagenesis of the peptide defined which residues were responsible for its biologic activity and integrin binding...
  53. pmc Breast tumour angiogenesis
    Stephen B Fox
    Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, 3002, Australia
    Breast Cancer Res 9:216. 2007
    ..The regulation of angiogenesis and the antivascular agents that are used in an antiangiogenic dosing schedule, both novel and conventional, are also summarized...
  54. ncbi Editorial: Angiogenesis agents
    Cezary Marcinkiewicz
    Curr Pharm Des 13:3543-4. 2007
  55. ncbi Antiangiogenic therapy in malignant glioma: promise and challenge
    Sith Sathornsumetee
    The Preston Robert Tisch Brain Tumor Center, Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Pharm Des 13:3545-58. 2007
    ..In this review, we will discuss the current development, promise and challenge of antiangiogenic therapy in malignant glioma...
  56. ncbi Intracellular calcium, endothelial cells and angiogenesis
    Luca Munaron
    Department of Animal and Human Biology, University of Torino and Nanostructured Interfaces and Surfaces Centre of Excellence NIS, Via Accademia Albertina 13, 10123 Torino, Italy
    Recent Pat Anticancer Drug Discov 1:105-19. 2006
    ....
  57. ncbi Understanding the immunoangiostatic CXC chemokine network
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, 1st School of Medicine, II University of Naples, Naples 80138, Italy
    Cardiovasc Res 78:250-6. 2008
    ..Here, we review insights on CXC chemokines in the context of immunoangiostasis and vascular damage...
  58. pmc Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications
    Rifat Hasina
    Department of Pathology, Medicine and Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA
    Lab Invest 88:342-53. 2008
    ..Finally, they suggest that studies in conjunction with the ongoing clinical trials that explore the correlation between target expression and clinical outcome are warranted...
  59. doi Mechanisms of angiogenesis and remodelling of the microvasculature
    Jean Sebastien Silvestre
    Cardiovasc Res 78:201-2. 2008
  60. pmc The periphery of the human fetal adrenal gland is a site of angiogenesis: zonal differential expression and regulation of angiogenic factors
    Hitoshi Ishimoto
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 0556, USA
    J Clin Endocrinol Metab 93:2402-8. 2008
    ..Ang1 stabilizes, whereas Ang2 destabilizes, vessels, increasing responsiveness to angiogenic stimuli such as vascular endothelial growth factor (VEGF)-A and fibroblast growth factor (FGF)-2...
  61. ncbi Murine epidermal side population possesses unique angiogenic properties
    Christopher C Oberley
    The Department of Dermatology, The University of Iowa, Iowa City, IA 52242, USA
    Exp Cell Res 314:720-8. 2008
    ..Therefore, we conclude that EpSPs possess unique angiogenic properties and that these cells may be indirectly responsible for the angiogenic response previously observed in our ischemic limb model...
  62. ncbi Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia
    Jewon Ryu
    Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong Songpa gu 138 736, Seoul 138 736, Republic of Korea
    Cardiovasc Res 78:333-40. 2008
    ..The present study investigated the detailed mechanism by which fractalkine (Fkn), a CX3C chemokine, induces angiogenesis and its functional implication in alleviating ischaemia in vivo...
  63. ncbi CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis
    Mohamed A Zayed
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Circ Res 101:1185-93. 2007
    ..These data therefore reveal a critical role for CIB1 in ischemia-induced pathological and adaptive angiogenesis...
  64. ncbi Angiogenesis factor pattern differs in acute lymphoblastic leukemia and chronic lymphocytic leukemia
    Salah Aref
    Hematology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt
    Hematology 12:319-24. 2007
    ..In conclusion, our data suggest that the driving forces of angiogenic factors (VEGF, TNF-alpha and MMP-9) in adult B-ALL appears different from that in B-CLL patients...
  65. ncbi From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now
    Roberta W C Pang
    Department of Medicine, Centre for Cancer Research, The University of Hong Kong, Hong Kong, SAR, China
    Oncology 72:30-44. 2007
    ..The management of advanced HCC is entering the era of molecular targeting therapy, which is of particular significance for HCC in view of the lack of existing effective systemic therapy for this cancer...
  66. ncbi Nerve growth factor as an angiogenic factor
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Microvasc Res 75:135-41. 2008
    ..This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions...
  67. ncbi Combined transmyocardial revascularization and cell-based angiogenic gene therapy increases transplanted cell survival
    Dan Spiegelstein
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 293:H3311-6. 2007
    ..Scar pretreatment with TMR combined with cell-based multigene therapy may maximize myocardial repair...
  68. ncbi [Angiogenesis and hematologic malignancy]
    Jean Marc Zini
    Service d angio hématologie, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris
    Bull Cancer 94:S241-6. 2007
    ..It will therefore be a future challenge to integrate anti-angiogenesis agents in currently existing treatment protocols to improve the outcome of therapy...
  69. ncbi Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma
    Mark E Kleinman
    Stanford University, Department of Surgery, PSRL, GK 201, 257 Campus Drive West, Stanford, CA, 94305 5148, USA
    Arterioscler Thromb Vasc Biol 27:2664-70. 2007
    ..We examined whether these mediators of EPC trafficking are upregulated during the proliferation of infantile hemangioma...
  70. ncbi Angiogenesis: molecular mechanisms of activation, promotion and maintenance
    Andreas Bikfalvi
    INSERM, E113, European Laboratory for Angiogenesis and Translational Research, Talence, France
    J BUON 12:S59-66. 2007
    ..Many players have been characterized and there are many more still to come. In this article I will review basic concepts and some of the major regulatory pathways and there implication in physiological and pathological angiogenesis...
  71. pmc Reversal of cellular roles in angiogenesis: implications for anti-angiogenic therapy
    Daniela Virgintino
    La Jolla Institute for Molecular Medicine, San Diego, Calif, USA
    J Vasc Res 45:129-31. 2008
  72. ncbi Skin-derived microorgan autotransplantation as a novel approach for therapeutic angiogenesis
    Pierre Voisine
    Angiogenesis Research Center and Interventional Cardiology Section, Division of Cardiology, BIDMC Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 294:H213-9. 2008
    ..Autotransplantation of SMOs constitutes a novel approach for safe and effective therapeutic angiogenesis with improvement in perfusion, normalization of microvascular reactivity, and increased expression of VEGF and CD31...
  73. pmc Chemokines as mediators of neovascularization
    Ellen C Keeley
    Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908 0466, USA
    Arterioscler Thromb Vasc Biol 28:1928-36. 2008
    ..In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization...
  74. ncbi Vascular endothelial growth factor, fibroblast growth factor 2, platelet derived growth factor and transforming growth factor beta released in human dental pulp following orthodontic force
    K A Derringer
    Department of Orthodontics, GKT Dental Institute, King s College Hospital, London SE5 9RW, UK
    Arch Oral Biol 49:631-41. 2004
    ....
  75. ncbi Tumor angiogenesis and molecular target therapy in ovarian carcinomas
    Masatsugu Ueda
    Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Hum Cell 18:1-16. 2005
    ..In this review, we describe current knowledge pertaining to mechanisms and regulation of angiogenesis in ovarian carcinomas with special reference to our recent research results...
  76. ncbi Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
    Brian D Kelly
    Program in Vascular Cell Engineering, Institute for Cell Engineering, Baltimore, MD, USA
    Circ Res 93:1074-81. 2003
    ....
  77. ncbi Matrix metalloproteinases and angiogenesis
    Joyce E Rundhaug
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, TX, 78957, USA
    J Cell Mol Med 9:267-85. 2005
    ..However, because of the multiple effects of MMPs on angiogenesis, careful testing of these MMP inhibitors is necessary to show that these compounds do not actually enhance angiogenesis...
  78. ncbi Circulating angiogenic cytokines in multiple myeloma and related disorders
    Halina Urba ska-Rys
    Department of Haematology, Medical University of Lodz, Copernicus Memorial Hospital, 93 513 Lodz, Pabianicka 62 st, Poland
    Eur Cytokine Netw 14:40-51. 2003
    ..001) and VEGF and bFGF (rhô = 0.197, p < 0.02). In conclusion, our data indicate a strong relationship between angiogenic cytokine serum levels and clinical course as well as selected laboratory parameters of patients with MM...
  79. pmc The axonal attractant Netrin-1 is an angiogenic factor
    Kye Won Park
    Program in Human Molecular Biology and Genetics, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 101:16210-5. 2004
    ..Thus, we demonstrate that Netrin-1 is a secreted neural guidance cue with the unique ability to attract both blood vessels and axons, and suggest that other cues may also function as vascular endothelial growth factors...
  80. ncbi Apelin is a novel angiogenic factor in retinal endothelial cells
    Atsushi Kasai
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
    Biochem Biophys Res Commun 325:395-400. 2004
    ..This is the first report showing that apelin is an angiogenic factor in retinal endothelial cells...
  81. ncbi Molecular targets in the inhibition of angiogenesis
    Arkadiusz Z Dudek
    Division of Hematology, Oncology and Transplantation, Department of Medicine and Comprehensive Cancer Center, 420 Delaware Street, MMC 480, University of Minnesota, Minneapolis, MN 55455, USA
    Expert Opin Ther Targets 7:527-41. 2003
    ....
  82. ncbi Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
    Candy K Chan
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lab Invest 85:721-33. 2005
    ..02). Strain-dependent expression of both pro- and antiangiogenic growth factors may determine heterogeneity in the angiogenic response and potentially, susceptibility to angiogenesis-dependent diseases...
  83. ncbi Leptin-induced differentiation of HUVEC
    Anna Polus
    Department of Clinical Chemistry, The Jagiellonian University Medical College, Krakow, Poland
    Acta Cardiol 59:229-30. 2004
  84. ncbi Influence of alpha-tumor necrosis factor and beta-interleukin-1 on production of angiogenetic factors and thymidine phosphorylase activity in immortalized human decidual fibroblasts in vitro
    Takashi Hayashi
    Department of Obstetrics and Gynecology, Saitama Medical Centre, Saitama Medical School, Kawagoe, Saitama, Japan
    J Obstet Gynaecol Res 32:15-22. 2006
    ..The aim of the present study was to investigate regulatory mechanisms of angiogenesis in the decidua using immortalized human decidual fibroblasts...
  85. ncbi Angiogenic and antiangiogenic balance regulates concomitant antitumoral resistance
    O Graciela Scharovsky
    Instituto de Genética Experimental, School of Medical Sciences, University of Rosario, Rosario, Argentina
    Clin Exp Metastasis 21:177-83. 2004
    ..The levels of the factors involved in this phenomenon can vary in the different tumor models, but the trend favoring the inhibition of angiogenesis is always conserved...
  86. ncbi Differential gene and protein expression in abluminal sprouting and intraluminal splitting forms of angiogenesis
    James L Williams
    Angiogenesis Research Group, Division of Cardiovascular Sciences, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    Clin Sci (Lond) 110:587-95. 2006
    ....
  87. ncbi Advances in understanding angiogenesis through molecular studies
    Mijung Kwon
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
    Int J Radiat Oncol Biol Phys 64:26-32. 2006
    ..Elucidation of the pathways that mediate both angiogenic and antiangiogenic responses will help us to develop better anticancer therapies...
  88. ncbi Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer
    H Hatanaka
    Department of Pathology, Tokai University School of Medicine, Kanagawa 259-1193, Japan
    Clin Cancer Res 7:1287-92. 2001
    ..0039). The IL-10 expression did not show any significant correlation with the expression of other factors. These results suggested that tumor-produced IL-10 promotes stromal vascularization through expression of Ang-1, Ang-2, and TIE2...
  89. ncbi Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin
    David O Zamora
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Mol Vis 13:2058-65. 2007
    ..Because the proteome ultimately determines the behavior of any given cell, however, it is critical to determine whether molecular differences exist at the level of protein expression...
  90. ncbi Quantitative image analysis of laser-induced choroidal neovascularization in rat
    J L Edelman
    Department of Biological Sciences, Allergan Inc, Irvine, CA, USA
    Exp Eye Res 71:523-33. 2000
    Rodent models of laser-induced choroidal neovascularization (CNV) are now extensively used to identify angiogenic proteins, determine the role of specific genes with knockout mice, and evaluate the efficacy and safety of anti-angiogenic ..
  91. ncbi The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets
    Nadia M Bambace
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Platelets 21:85-93. 2010
    ..The differential release of pro-angiogenic and anti-angiogenic proteins from the platelet has been demonstrated for proteinase activated receptors (PARs)...
  92. pmc Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders
    Asma Khalil
    The Homerton University Hospital NHS Trust, Queen Mary and Westfield College, University of London, London, United Kingdom
    PLoS ONE 3:e2766. 2008
    ..However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension and proteinuria in pre-eclampsia (PE)...
  93. ncbi Increased expression of urinary matrix metalloproteinases parallels the extent and activity of vascular anomalies
    Jennifer J Marler
    Vascular Anomalies Center and Department ofSurgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 116:38-45. 2005
    Matrix metalloproteinases (MMPs) and the angiogenic proteins basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) have been implicated in mechanisms of human cancer and metastasis...
  94. ncbi Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 84:1262-71. 2007
    ..We aimed to evaluate the expression of angiogenic factors in hepatitis C virus (HCV)-HCC tissues and the utility of angiogenesis soluble factors as noninvasive markers of HCC and tumor growth...
  95. ncbi The rationale and future potential of angiogenesis inhibitors in neoplasia
    G Gasparini
    Division of Medical Oncology, Azienda Ospedali Riuniti Bianchi Melacrino Morelli, Reggio Calabria, Italy
    Drugs 58:17-38. 1999
    ..Therefore, adequate and well designed clinical trials should be performed for a proper evaluation of antiangiogenic agents, by determination and monitoring of surrogate markers of angiogenic activity...
  96. ncbi Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5
    Keith R McCrae
    Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Curr Cancer Drug Targets 5:519-28. 2005
    ..A role for tropomyosin in mediating the anti-angiogenic signals of other anti-angiogenic proteins such as endostatin and histidine-proline-rich glycoprotein (HPRG) has also been reported...
  97. ncbi Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation
    Hadi Aslan
    Skeletal Biotechnology Laboratory, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    J Bone Miner Res 21:1935-45. 2006
    ..Among these genes the dickkopf homolog 3 (Dkk3) was upregulated and further studies showed that its expression affects in vitro and in vivo osteogenesis. This study indicates a possible role of Dkk3 in regulating bone formation...
  98. ncbi Angiogenic gene therapy
    Christer Sylven
    Department of Cardiology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Drugs Today (Barc) 38:819-27. 2002
    ..Two possibilities exist in terms of local delivery of the angiogenic proteins. One is the delivery of the protein in a slow-release formulation...
  99. ncbi CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1
    Jeff S Isenberg
    Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:26069-80. 2006
    ..Therefore, ligation of either CD36 or CD47 is sufficient to inhibit NO-stimulated vascular cell responses and cGMP signaling, but only CD47 is necessary for this activity of thrombospondin-1 at physiological concentrations...
  100. pmc Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization
    Peng Chen
    Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Mol Vis 16:310-9. 2010
    ..To determine the effectiveness of multigene-based anti-angiogenic gene therapies for experimental murine corneal neovascularization (corneal NV)...
  101. ncbi Hirudo medicinalis: a new model for testing activators and inhibitors of angiogenesis
    M de Eguileor
    Department of Structural and Functional Biology, University of Insubria, via J H Dunant 3, 21100 Varese, Italy
    Angiogenesis 4:299-312. 2001
    ..medicinalis can be used as a reproducible model for testing activators or inhibitors of angiogenesis, and for investigating the biochemical, ultrastructural and cellular processes involved in new vessel formation...

Research Grants62

  1. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..STB is the source of "placental debris", cytokines, and pro-inflammatory and anti-angiogenic proteins, which become elevated in mothers diagnosed with PE...
  2. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..The effect of maspin on the levels of pro-and anti-angiogenic proteins synthesized by corneal epithelial and stromal fibroblast cells and heme- and lymph-endothelial cells will ..
  3. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..Building on the promising pre- clinical data generated to date, the objective of the proposed STTR program is to bring the CA5 product candidate into clinical testing. ..
  4. Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
    Sarosh Rana; Fiscal Year: 2013
    ..Currently, the only treatment for PE is delivery. Recent research has shown that certain angiogenic proteins are associated with and may be involved in the pathogenesis of PE...
  5. Pro-inflammatory regulation of angiogenic gene expression in human trophoblast
    Donald S Torry; Fiscal Year: 2012
    ..It is well accepted that altered production of pro- and anti-angiogenic proteins by the placenta regulate blood vessel function and directly contributes to systemic disease...
  6. Functional MRI Monitoring of Hepatic Chemoembolization
    ANDREW CHRISTIAN LARSON; Fiscal Year: 2011
    ..Specific Aim 3 will correlate perfusion changes during TACE with tumor angiogenesis and clinical outcomes. Angiogenic proteins-- vascular endothelial growth factor (VEGF) and hypoxia inducible factor-11 (HIF-11) will be measured on ..
  7. Optimizing Therapeutic Revascularization by Endothelial Cell Transplantation
    W Mark Saltzman; Fiscal Year: 2013
    ..We have shown that vessel self assembly can be enhanced by incorporating sustained delivery of pro-angiogenic proteins that act on ECs...
  8. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy L Silverstein; Fiscal Year: 2012
    ..bears structural similarity to CD36 and can act as a "decoy", blocking the activity of TSR-containing anti-angiogenic proteins. These discoveries have led to the hypothesis that angiogenesis is modulated by the fine control of CD36, ..
  9. Bioengineering A Bioartificial Pancreas
    Emmanuel C Opara; Fiscal Year: 2010
    ..The specific aims of this proposal are: 1) To design an optimum delivery system for angiogenic proteins to induce neovascularization around alginate microcapsules...
  10. Regenerating the Heart with Engineered Human Cardiac Tissue
    KAREEN LOUISE KREUTZIGER COULOMBE; Fiscal Year: 2013
    ..In Aim 1, we will develop biodegradable alginate microspheres loaded with the angiogenic proteins vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)...
  11. Spatiotemporal Delivery of miRNA Anatgomir for Promoting Vascular Self-Assembly
    W Mark Saltzman; Fiscal Year: 2012
    ..Vessel self assembly can also be enhanced by sustained delivery of pro- angiogenic proteins that act on ECs or PCs, especially when an EC-directed agent, vascular endothelial growth factor (VEGF), is ..
  12. Nanoparticles for Harvesting and Targeting Angiogenic Proteins
    Mauro Ferrari; Fiscal Year: 2010
    ..provided by applicant): This R21/R33 application entitled "Nanoparticles for Harvesting and Targeting Angiogenic Proteins" has as its hypothesis that development and refinement of surface characteristics of silica chips with ..
  13. OV Therapy Induced Changes in Tumor Secretome and Their Impact on Therapy
    Balveen Kaur; Fiscal Year: 2012
    ..My laboratory has been investigating changes in the tumor secreted angiotome (secreted angiogenic proteins) after OV therapy...
  14. Protein Stability in Polymer Delivery Systems
    Steven P Schwendeman; Fiscal Year: 2011
    ..model proteins and peptides in PLGA delivery systems, 3) application of the stabilization methodology to the delivery of angiogenic proteins, and 4) in vivo assessment of the controlled release of biologically active angiogenic proteins
  15. Predictive model of pro- and anti-angiogenic factors involved in breast cancer
    STACEY DELERIA FINLEY; Fiscal Year: 2012
    ..This project aims to develop a quantitative model to study the balance of promoters and inhibitors of angiogenesis and apply the model to aid in the development of cancer therapeutics. ..
  16. Effects of mTOR inhibitors on multiple myeloma tumors
    Patrick Frost; Fiscal Year: 2009
    ..is due to inhibition of the cap-independent translation salvage pathways of critical survival and angiogenic proteins in vitro and in vivo...
  17. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
    ..Gene therapy approaches are well suited for the experimental delivery of diverse anti-angiogenic proteins, given the ease of vector construction versus recombinant protein, and the convenience of single injection ..
  18. Phase 2 Trial of Angiotensin-(1-7) for the Treatment of Metastatic Sarcoma
    W Jeffrey Petty; Fiscal Year: 2012
    ..Completion of this study will lead to an improved understanding of the clinical benefits and adverse events associated with this treatment. ..
  19. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
    ..There are several other known anti-angiogenic proteins, and it is intriguing that they share some properties with anastellin...
  20. Biomaterials for Cell Triggered Gene Transfer
    Tatiana Segura; Fiscal Year: 2009
    ..research is to take advantage of this MMP expression profile during wound healing to deliver different pro-angiogenic proteins at different times to promote the formation of a mature vasculature and thus enhance the rate of wound ..
  21. ANTI-ANGIOGENIC PEPTIDES DERIVED FROM HUMAN KININOGEN
    Andrew Mazar; Fiscal Year: 1999
    ..The therapeutic targeting of angiogenesis has been validated in vivo and may have application in both the acute and chronic use setting. ..
  22. NEDD8-MODIFICATION IN VON HIPPEL-LINDAU SYNDROME
    Tetsu Kamitani; Fiscal Year: 2003
    ..abstract_text> ..
  23. Nanoparticles for Harvesting and Targeting Angiogenic Proteins
    Mauro Ferrari; Fiscal Year: 2006
    This R21/R33 application entitled "Nanoparticles for Harvesting and Targeting Angiogenic Proteins" has as its hypothesis that development and refinement of surface characteristics of silica chips with nanocharacteristics can enhance ..
  24. Novel BIV-based vectors with retina-specific promoter
    MOJUN JIN; Fiscal Year: 2005
    ..This tissue-specific lentiviral transfer system has tremendous commercial values because it will be very effective for the use of treating CNV in degenerative ocular diseases. ..
  25. ENDOSTATIN ACTION--SIGNALING AND MUTANTS
    Vikas Sukhatme; Fiscal Year: 2003
    ..Limitations, at least for use of anti-angiogenic proteins, are that delivery cannot be oral and large amounts are currently needed for efficacy...
  26. A Phase 2 study of AZD2171 in Recurrent Glioblastoma
    Tracy Batchelor; Fiscal Year: 2006
    ..also proposing to measure the number of circulating endothelial cells as well as a number of circulating angiogenic proteins including VEGF...
  27. Molecular targets of hypoxia in signaling cancer
    Othon Iliopoulos; Fiscal Year: 2007
    ..These studies will test whether HIF is necessary for tumor angiogenesis. Reagents generated at the course of these proof-of-principle experiments may provide the direct basis for anti-cancer drug development. ..
  28. STRESS RESPONSES IN MAMMALIAN CELLS
    Yong Lee; Fiscal Year: 2001
    ..The observation of the induction of these angiogenic proteins under these circumstances could have significant implications on the process of tumorigenesis...
  29. New Angiostimulator for Ischemic Heart Disease
    Krzysztof Bojanowski; Fiscal Year: 2005
    ..Currently, therapeutic angiogenesis focuses on gene therapy with angiogenic proteins such as DEL-1, VEGF and FGF...
  30. Targeted Assessment of Antiangiogenic Therapy
    James Abbruzzese; Fiscal Year: 2006
    ..and the specific signaling pathways through which they control the expression of angiogenic proteins; (2) To clinically validate specific methods, developed in preclinical models, for detecting endothelial ..
  31. Anti-angiogenic signaling molecules in retinal cells
    Nader Rahimi; Fiscal Year: 2004
    ..our long-term goal is to begin to apply the information obtained from this project to the design of strategies to regulate angiogenesis in clinical settings. ..
  32. ROLE OF TGF BETA 1 IN RENAL CANCER
    S Karumanchi; Fiscal Year: 2004
    ..New methodologies the applicant will learn include RNA gel shifts, RNase protection assays, UV crosslinking, mutagenesis, mutation analysis, animal work and immunohistochemistry. ..
  33. Placental Gene Expression Profile in Preeclampsia
    S Karumanchi; Fiscal Year: 2004
    ....
  34. MOLECULAR CONTROL OF MYOGENESIS
    Kenneth Walsh; Fiscal Year: 2005
    ....
  35. Diabetic Retinopathy Clinical Research Network
    Lloyd Aiello; Fiscal Year: 2005
    ..This proposal details the manner in which the specific goals of the network will be fostered under the guidance of the Study Chair. ..
  36. PATHOLOGY OF MITOSIS IN VASCULAR SMOOTH MUSCLE
    Kenneth Walsh; Fiscal Year: 2005
    ..Aim 3: To determine the requirement of Cks1 function for Akt1-induced VSMC polyploidization. Aim 4: To generate transgenic animals that over express Cks1 or Akt1 in vascular smooth muscle. ..
  37. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  38. TRANSCRIPTIONAL CONTROL OF CARDIOVASCULAR PATHOLOGY
    Kenneth Walsh; Fiscal Year: 2001
    ....
  39. POSTNATAL VASCULOGENESIS IN CARDIOVASCULAR DISEASE
    JEFFREY ISNER; Fiscal Year: 2002
    ....
  40. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  41. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  42. ANGIOSTATIN--MOLECULAR MECHANISMS AND INTERACTIONS
    DAVID SANE; Fiscal Year: 2002
    ..These studies will lead to a better understanding of the mechanisms of angiogenesis inhibition by angiostatin. ..
  43. DYSREGULATION OF MMP 9 DURING SKIN CARCINOGENESIS
    JOYCE RUNDHAUG; Fiscal Year: 2002
    ..abstract_text> ..
  44. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2001
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted. ..
  45. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2006
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  46. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre L Triozzi; Fiscal Year: 2010
    ....
  47. Defective PS Exposure in Neutrophil Apoptosis in CGD
    Donna Bratton; Fiscal Year: 2007
    ..It is expected that data from this investigation will identify novel potential therapeutic targets to address disordered inflammation of CGD. ..
  48. Is There a Link Between Alzheimer's and Atheroclerosis
    Paula Grammas; Fiscal Year: 2007
    ..abstract_text> ..
  49. REGULATION OF RENIN AND PREECLAMPTIC HYPERTENSION
    Dinesh Shah; Fiscal Year: 2001
    ..These studies will improve our understanding of the role of progesterone in the regulation of reproductive renin and may provide a novel direction for investigating the pathophysiology of preeclampsia. ..
  50. Therapy of thrombocytopenic disorders by chemokines
    Shahin Rafii; Fiscal Year: 2007
    ..being evaluated in phase I clinical trials, would provide the platform for assessing the role of these agents in amelioration and rapid restoration of thrombocytopenia Induced by chemotherapy and irradiation [unreadable] [unreadable]..
  51. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. [unreadable] [unreadable] [unreadable]..
  52. Role of VEGF in Glomerular Endothelial Health & Diseases
    S Karumanchi; Fiscal Year: 2007
    ..abstract_text> ..
  53. Mechanisms of Pregnancy Induced Hypertension
    Babbette LaMarca; Fiscal Year: 2007
    ....
  54. VEGFR-1 and VEGFR-2 in angiogenesis
    Nader Rahimi; Fiscal Year: 2006
    ..Once we determine the mechanism by which VEGF receptors are engaged it will be possible to attenuate the angiogenic signal transduction relay by developing targeted therapeutic interventions aimed at angiogenesis suppression ..
  55. SIGNALING PATHWAYS IN HEART FAILURE
    Kenneth Walsh; Fiscal Year: 2009
    ..These studies should provide a better understanding of the mechanism that regulate adaptive and maladaptive remodeling, and provide new insights about the development and treatment of heart failure. ..
  56. Mechanisms of Angiogenesis
    Kenneth Walsh; Fiscal Year: 2009
    ..LKB1-knockout mice will be created and their baseline phenotype will be assessed. Endothelial LKB1-deficient mice will be subjected to ischemic stresses and vascular responses will be evaluated. ..
  57. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  58. Molecular Control of Myo/Angiogenesis
    Kenneth Walsh; Fiscal Year: 2009
    ....
  59. MOLECULAR REGULATION AND ROLE OF PLACENTA GROWTH FACTOR
    Donald S Torry; Fiscal Year: 2010
    ....
  60. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
  61. Cardiac Disease and Regeneration
    Stefanie Dimmeler; Fiscal Year: 2005
    ..As aging is a major risk factor for cardiovascular disease a special session will focus on the molecular determinants of aging and its role in cardiac diseases. ..
  62. Nutrition, Fetal Growth, and Placental Angiogenesis
    Lawrence P Reynolds; Fiscal Year: 2010
    ..abstract_text> ..